Vaxcyte is a biotechnology company focused on developing novel vaccines to address infectious diseases.

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is&nbsp;&nbsp; looking&nbsp;&nbsp; for&nbsp;&nbsp; a highly motivated and skilled individual to join Vaxcyte’s Vaccine Product Development organization as a Sr Associate Scientist in the Protein Development and Clinical Manufacturing group. The successful candidate will play a crucial role in designing, implementing, and optimizing automation solutions to establish high throughput fermentation process development workflows. The successful candidate will have the following skills and qualities:&nbsp; Proven experience in designing, programming, and implementing laboratory automation systems A passionate researcher with a knack for technology innovation to improve performance and efficiency An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals. Strong organizational and planning skills. Essential Functions: Be part of the Ambr operation team and execute high throughput upstream process development experiments. Design and develop automation solutions for liquid handling, sample preparation and analysis workflows. Collaborate with Vaxcyte Benchling to enable efficient data capture from automated processes. Diagnose and troubleshoot technical issues related to automation hardware, software, and protocols. Author SOPs (standard operating procedure) and train laboratory personnel on the proper operation, maintenance, and troubleshooting of automation systems. Requirements:&nbsp; BS in Chemical Engineering or Chemistry/Biochemistry with 5+ years of relevant Pharma/Biotech industry experience, or MS in Chemical Engineering or Chemistry/ Biochemistry with 3+ years of relevant Pharma/Biotech industry experience. Strong understanding of laboratory workflows in biotech process development. Familiarity with various automation platforms and technologies, such as liquid handling robots, robotic arms, and plate readers. Experience with Tecan Fluent, Biomek i-series, and/or Ambr 250HT system is a plus. Knowledge of data analysis and visualization tools. Excellent problem-solving skills and attention to detail. Effective communication skills and the ability to collaborate with cross-functional teams. Reports to:&nbsp;Senior Scientist, Upstream Development for Protein Development &amp; Manufacturing &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $118,000 – $138,000&nbsp;(SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist, Upstream Development for Protein Development and Manufacturing

<div class="content-intro"><h3><strong>Join our Mission to Protect Humankind!</strong></h3>
<div>Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp;</div>
<div>&nbsp;</div>
<div><strong>WHAT</strong>&nbsp;we do is every bit as important as&nbsp;<strong>HOW</strong>&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values:</div>
<div>&nbsp;</div>
<div>*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.</div>
<div>&nbsp;</div>
<div>*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.</div>
<div>&nbsp;</div>
<div>*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.</div>
<div>&nbsp;</div>
<div>*MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.</div></div><h3><strong>Summary:</strong></h3>
<p>Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team.&nbsp;The Associate Scientist II, Analytical Development, is responsible for executing analytical testing and supporting method development activities for biologics/vaccine development programs. This role will perform routine and non-routine analytical assays using modern analytical techniques and will contribute to method optimization, troubleshooting, and continuous improvement initiatives under supervision. The position requires demonstrated hands-on laboratory experience, strong technical execution, and the ability to work independently on routine tasks while supporting more complex development activities.</p>
<h3>Essential Functions:</h3>
<p>Analytical Testing &amp; Data Generation</p>
<ul>
<li>Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques).</li>
<li>Prepare samples, reagents, standards, and buffers according to established protocols.</li>
<li>Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable).</li>
<li>Perform data processing and preliminary interpretation; summarize findings for review by senior scientists.</li>
<li>Maintain accurate and timely documentation in laboratory notebooks or electronic systems.</li>
</ul>
<p>Method Development &amp; Troubleshooting (Under Supervision)</p>
<ul>
<li>Support method development, optimization, and qualification activities under the guidance of senior scientists.</li>
<li>Assist in designing experiments to evaluate method parameters and robustness.</li>
<li>Troubleshoot assay performance issues and instrument-related problems, proposing potential solutions for review.</li>
<li>Participate in method transfer activities, including protocol execution and documentation.</li>
<li>Contribute to drafting and revising analytical methods, SOPs, protocols, and technical reports.</li>
</ul>
<p>Laboratory Operations &amp; Instrumentation</p>
<ul>
<li>Coordinate instrument service activities and assist with vendor interactions as needed.</li>
<li>Ensure laboratory organization, cleanliness, and proper material storage.</li>
<li>Manage inventory of reagents, standards, and consumables; assist with procurement and restocking.</li>
</ul>
<p>Safety &amp; Compliance</p>
<ul>
<li>Follow all Environmental Health &amp; Safety (EHS) policies and laboratory safety practices.</li>
<li>Handle chemicals and biological materials safely and in compliance with regulatory requirements.</li>
<li>Ensure proper waste disposal and adherence to hazardous material handling procedures.</li>
<li>Support audit and inspection readiness activities where applicable.</li>
</ul>
<p>Team Collaboration</p>
<ul>
<li>Collaborate with cross-functional teams to support project timelines and deliverables.</li>
<li>Provide clear communication on experimental progress, risks, and results.</li>
<li>Contribute to a positive, compliant, and scientifically rigorous laboratory culture.</li>
</ul>
<h3>Requirements:&nbsp;</h3>
<ul>
<li>Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline with 2+ years, or Master’s degree with 1+ years of relevant laboratory experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered.</li>
<li>Hands-on experience with analytical techniques such as chromatography, electrophoresis, or immunoassays is required.</li>
<li>Experience supporting method development or optimization activities preferred.</li>
<li>Solid understanding of analytical chemistry or biochemistry principles.</li>
<li>Experience with method troubleshooting and data interpretation.</li>
<li>Familiarity with analytical software and data analysis tools.</li>
<li>Strong attention to detail and organizational skills.</li>
<li>Ability to work independently on routine assignments and manage multiple tasks.</li>
<li>Effective written and verbal communication skills.</li>
<li>Ability to work in a laboratory environment for extended periods.</li>
<li>Ability to lift up to 25 lbs.</li>
<li>Use of personal protective equipment (PPE) required.</li>
<li>Contribute to a positive, inclusive, and safety-focused laboratory culture.</li>
</ul>
<div><strong>Reports to: </strong>Senior Scientist, Analytical Development for Raw Materials</div>
<div>&nbsp;</div>
<div><strong>Location: </strong>San Carlos, CA</div>
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<div><strong>Work Arrangement: </strong>Onsite (5 days per week)</div>
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<div><strong>Expected Contract Length:&nbsp;</strong>12 Months</div>
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<div><strong>Hourly Range:&nbsp;</strong>$51 - $56 (SF Bay Area)</div>
<p>&nbsp;</p><div class="content-conclusion"><p><em>We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.</em></p>
<p>&nbsp;</p></div>

Associate Scientist II, Analytical Development, Raw Materials (Contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is undergoing a major ERP transformation, moving from NetSuite to SAP S/4HANA to support its rapid growth&nbsp;and upcoming transition to commercial operations.&nbsp;The&nbsp;Senior&nbsp;IT&nbsp;Business&nbsp;Systems&nbsp;Analyst (BSA),&nbsp;SAP&nbsp;Finance&nbsp;will play a critical role in bridging Finance and IT, ensuring a smooth transition and successful implementation of SAP S/4HANA Finance modules. This position requires strong functional&nbsp;expertise&nbsp;in SAP Finance, deep understanding of accounting processes, and experience in ERP migration projects.&nbsp; Essential Functions: Support the migration from&nbsp;NetSuite to SAP S/4HANA, ensuring data integrity and process continuity.&nbsp; Collaborate with Finance and IT teams to design future-state processes aligned with&nbsp;Vaxcyte’s&nbsp;business needs.&nbsp;&nbsp; Assist&nbsp;in data mapping, cleansing, and validation during migration.&nbsp; In-depth knowledge of SAP systems, including SAP S/4HANA and integration techniques.&nbsp; Configure and&nbsp;maintain&nbsp;SAP Finance modules&nbsp;including Financial Accounting (FI), Controlling (CO), Treasury &amp; Cash Management, Financial Close &amp; Reporting, and Procurement.&nbsp;&nbsp; Work closely with Finance stakeholders (Accounting, FP&amp;A,&nbsp;Procurement) to capture requirements.&nbsp; Translate business needs into functional specifications for SAP configuration.&nbsp; Help develop and document business process flows.&nbsp; Develop and execute test plans for SAP Finance processes.&nbsp; Support&nbsp;User Acceptance Testing (UAT)&nbsp;and resolve issues promptly.&nbsp; Create training materials and deliver sessions for Finance users transitioning from NetSuite.&nbsp; Provide ongoing support&nbsp;post go-live.&nbsp; Ensure compliance with GAAP and biotech industry standards.&nbsp; Requirements:&nbsp; Minimum 7&nbsp;years of experience&nbsp;as a BSA with SAP Finance modules.&nbsp;Other combinations of education and/or experience may be considered.&nbsp; Bachelor’s degree in&nbsp;Finance, Accounting, Information Systems, or related field.&nbsp; Strong analytical and problem-solving skills, with the ability to&nbsp;identify&nbsp;issues and implement effective solutions.&nbsp; Experience in&nbsp;identifying&nbsp;and managing project risks, with a proactive approach to mitigation.&nbsp; &nbsp;Familiarity with&nbsp;change management principles and techniques to&nbsp;facilitate&nbsp;smooth transitions and adoption of new systems.&nbsp; Hands-on experience with&nbsp;SAP S/4HANA Finance&nbsp;(implementation or migration projects preferred)&nbsp;and Fiori applications.&nbsp;&nbsp; Experience with&nbsp;Netsuite&nbsp;preferred.&nbsp; Experience developing and mapping business process flows using Visio or similar tool&nbsp; Strong understanding of&nbsp;financial processes&nbsp;and ERP migration best practices.&nbsp; Excellent communication and stakeholder management skills.&nbsp; SAP certification in FI/CO&nbsp; Expertise&nbsp;with agile&nbsp;methodology, global deployments, and data migration planning.&nbsp; Experience working in&nbsp;GxP&nbsp;validated and SOX regulated systems&nbsp; Knowledge of&nbsp;integrated tools&nbsp;(e.g.,&nbsp;BlackLine, Concur, Ariba) and reporting solutions.&nbsp; Other combinations of education and/or experience may be considered.&nbsp; Reports to:&nbsp;Director, IT Finance Systems &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior IT Business Systems Analyst, SAP Finance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for a talented Document Control Specialist, who will be responsible for the processing of GxP documentation as part of the Quality Management System. This includes, but is not limited to, Standard Operating Procedures, Work Instructions, Forms, and Templates. Essential Functions: Maintain Quality System documentation in Veeva (electronic document control system) and other electronic systems where required. Format documents to comply with Vaxcyte templates. Independently perform the QA document control function, managing document workflows in Veeva, tracking, processing, routing, distributing, and archiving documents/records with overall responsibility for document control Engage key clients to understand expectations and problem areas and has the ability to address and resolve conflicts. Participate in developing and editing of new SOPs and work instructions. Ability to identify risks to program/process and propose solutions. Work closely with functional areas for daily management of routing, revisions, approval, and filing of documents within defined timelines. Organize and ensure accurate and reliable filing systems for all electronic Requirements:&nbsp; Bachelor’s BA/BS degree or equivalent experience and minimum of 5 years of biopharmaceutical industry experience. Other combinations of education and/or experience may be considered. Experience working with documents and records in a GxP environment relating to manufacturing and testing activities. Familiar with Veeva Vault in a Document Control capacity. Understanding of current regulatory expectations including 21CFR Part 11 requirements. Strong professional interpersonal and communications skills, both verbal and written, to provide clear direction for the business, vendors, and internal stakeholders. Strong attention to detail, organizational skills, ability to work in a faced paced environment. Ability to meet deadlines and multi-task efficiently. Proficient with Microsoft Office Suite, Word, Excel, PowerPoint. Reports to: Director, Document Control &nbsp; Location: San Carlos, CA; Hybrid &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $115,000 – $134,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Document Control Specialist III

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Director, Medical Affairs is a senior leadership role responsible for shaping and executing the medical strategy for the company’s vaccine portfolio. This position combines traditional headquarters medical affairs responsibilities with direct oversight of a Medical Science Liaison (MSL) team and engagement with national vaccine recommending bodies and professional organizations. The role ensures scientific excellence, compliance, and alignment with Vaxcyte and public health priorities. Essential Functions: Contribution to development and implementation of medical affairs strategy for vaccines across the product lifecycle. Provide scientific and clinical expertise to support regulatory submissions, labeling, and safety monitoring. Collaborate with clinical development, regulatory, and commercial teams to ensure consistent scientific messaging. Offer strategic input and thought leadership in publication planning, medical education, and evidence generation initiatives. Monitor emerging data, guidelines, and competitive intelligence to inform strategy. Manage and mentor a team of MSLs, ensuring effective scientific exchange and stakeholder engagement. Align field insights with HQ strategy to drive evidence-based decision-making. Establish performance metrics and professional development pathways for MSLs. Foster collaboration between HQ and field medical teams to ensure seamless execution. Build and maintain relationships with key organizations making vaccine recommendations Represent the company in scientific and policy discussions related to immunization guidelines and vaccine adoption. Provide medical leadership at advisory boards, scientific congresses, and public health forums. Influence vaccine policy and recommendations through evidence-based advocacy. Requirements:&nbsp; Advanced degree (PharmD, PhD, MD, or equivalent) in life sciences, immunology, infectious diseases, or public health. A minimum of 12 years progressive experience in medical affairs, including leadership roles. Proven track record in vaccines or infectious disease therapeutic areas. Experience managing MSL teams and integrating field insights into HQ strategy. Strong understanding of immunization policy, public health systems, and regulatory frameworks. Exceptional communication, presentation, and interpersonal skills. Ability to travel up to 70% of the time. Other combinations of education and/or experience may be considered. Reports to:&nbsp;Vice President, Medical Affairs &nbsp; Location:&nbsp;Remote - US &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $266,000 - $310,000&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Medical Affairs

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Director, Medical Operations is a senior leadership role responsible for overseeing medical communications, medical information, and operations for the organization. This position ensures scientific accuracy, compliance, and operational excellence across all medical affairs activities, while supporting the company’s mission to advance immunization and public health. Essential Functions: Lead development of scientific communication strategies, including publications, congress presentations, and internal training materials. Oversee creation of scientific and medical content for advisory boards, symposia, and scientific meetings. Support consistent and accurate messaging across medical affairs and commercial teams. Drive publication planning and execution in collaboration with partners, including clinical development and external experts. Design and implement a transparent, compliant medical education grant process. Establish and lead the medical information function for vaccines, including processes, systems, and staffing. Oversee medical affairs operations, including budget management, compliance, and process optimization. Provide leadership in governance processes, ensuring adherence to regulatory and ethical standards. Requirements:&nbsp; Advanced degree (PharmD, PhD, MD, or equivalent) in life sciences, immunology, infectious diseases, or public health. A minimum of 12 years of progressive experience in medical affairs, medical communications, or medical information, with leadership responsibilities. Proven expertise in vaccines or infectious disease therapeutic areas. Experience building medical information functions and developing medical education grant processes. Strong knowledge of compliance frameworks, regulatory requirements, and industry standards. Exceptional leadership, communication, and strategic thinking skills. Ability to travel up to 25% of the time. Other combinations of education and/or experience may be considered. Reports to:&nbsp;Vice President, Medical Affairs &nbsp; Location:&nbsp;Remote - US &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $258,000 - $301,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Medical Affairs Operations

Senior Director, Medical Affairs (West)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Scientist II to manufacture and test all reagents required for&nbsp;immunoassay detection of multi-valent vaccines. In particular, the reagents we are using need to be conjugated to&nbsp;different entities and then characterized and catalogued for our multiplexed assays. Extreme control of this assay is&nbsp;required to maintain DS shelf life and more importantly, ensuring DP compounding is successful in relation to the final&nbsp;dose of each DS in the clinic. We require an Associate Scientist II who will continue the development and optimization of assay suites for our current&nbsp;3 programs, and for upcoming research projects. This person will be part of a larger team that will continue this&nbsp;development. The role requires an extremely high level of organization, and the ability to maintain large volumes of&nbsp;data for the various DS and DP entities. In addition, the successful candidate will require significant experience in&nbsp;developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes&nbsp;generating high-affinity antibodies specific to the antigen. Essential Functions: Help continue the development and optimization of assay suites for our current programs, and for the&nbsp;following research projects. Have an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities. Demonstrate experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen and reviewing production protocols, requesting quotes, interacting with vendors, collecting and providing updates on production timelines. Collaborate closely with external Vaxcyte Team members and to ensure supply/demand, DS and DP methods, CMO status and timelines are all in sync with assay development activities to hit milestones as needed. Requirements:&nbsp; Bachelor’s degree (BSc) in Molecular Biology, Chemistry, Analytical Chemistry, or Organic Biochemistry with a minimum 2 years of relevant experience, or Master’s degree (MSc) in the same fields with minimum 1 year of relevant experience or an equivalent combination of education and experience. Ideal candidate will have a significant background in plate-based assay development and antibody characterization including Akta, HPLC and BLI. Experience in protein analysis such as SEC, HPLC, SDS-page, CE-SDS, and cIEF and binding kinetics is a plus. Having a high degree of organizational capabilities for both reagents and experimental scheduling a must. Prior experience of transferring methods to external partners for validation and GMP will be of a significant benefit, and first-hand experience of a QC environment would also be advantageous. Experience in immunoassay development, qualification, validation, trouble shooting and aiding in OOS investigations is highly desired. The ability to present complex data sets and independently propose and design follow-up experiments are also required. Maintaining good laboratory practices, safety and record keeping for them-selves and their team is required. Reports to: Senior Manager, Clinical Serology, Nonclinical &amp; Immunoassay Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $105,000 – $122,000 *(SF Bay Area).&nbsp; &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Nonclinical & Immunoassay

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Associate Director, Clinical Data Management (CDM) will provide hands-on support for the execution of clinical data management activities across our clinical programs, from study start-up through study closeout, ensuring high quality data deliverables. This is a hands-on position that will include supervising additional CDM resources at Vaxcyte, based on the number of clinical trials in development. The Associate Director, Clinical Data Management will be responsible for the oversight and management of our Biometrics partners related activities conducted for clinical trials conducted by Vaxcyte, from study start-up through to study closeout, ensuring high quality data deliverables which are on time and within budget. Essential Functions: Supports the oversight for the execution of data management for all programs and studies; accountable for data management activities for a program. Clinical Data Management Strategy Support the implementation of CDM strategies aligned with Vaxcyte’s goals and clinical research best practices, including feedback into CDM system development and optimization as well as study data collection, reviewing, and reporting. Continuously improving data management processes and workflows to increase efficiency, data quality, and team productivity. Assist in establishing clinical data standards and processes to ensure consistency and quality across all Vaxcyte studies. Help develop CDM departmental SOPs and ensure staff adherence to company policies, SOPs, federal guidelines and GCPs. Track department budget both for external and internal spend. Supports data management activities for regulatory submissions. Study-Specific Data Management Execute study-specific data management and data quality plans and support documentation (data transfer specifications, data review/reconciliation plans, database lock plans, etc.) as required across the data lifecycle for various data sources (e.g., eCOA, etc.) Serve as a data management subject matter expert (SME) and primary point of contact. Ensure study-specific data management practices align with applicable regulatory requirements (e.g., GCP, FDA, GDPR). Oversee the end-to-end data lifecycle across studies, including development of CRFs and CRF guidelines, database setup, data quality validation. Lead data review, including query management, and activities required for interim and final database locks, ensuring high quality. Execute operational data management plans across studies to ensure on-time delivery of all study data. Ensures data management documentation is filed/archived according to applicable company and regulatory requirements. Reviews clinical study related documents from a data management perspective (e.g. protocol) and approves data management specific documents (e.g. Data Management Plan, Data Review Plan, CRF Completion Guidelines, etc.). Assist with tracking of status of data management related activities (e.g. EDC setup, data cleaning, coding, etc.). Assist with final sign off of project and study-related documents including, Edit Check Specifications, CRF Completion Guidelines, Data Transfer Agreements, etc.&nbsp; Cross-functional Collaboration Collaborate seamlessly with internal teams, including Clinical Operations, Clinicians, Biostatistics, Project Management, and Patient Recruitment, Enrollment, &amp; Engagement, to ensure successful study execution. Collaborate with Quality &amp; Regulatory and other internal/external experts (e.g., privacy, legal) to maintain compliance with relevant regulations and reporting/disclosure expectations and stay informed of evolving standards and focusing on continuous process improvement within clinical trial data management. Effectively represent data management at project review meetings, quality review meetings, and other stakeholder meetings. Assist clinical study team with the planning, preparation, and on-site support of investigators meetings and CRA trainings. Provides oversight for Biometrics, Data Management CROs, EDC, and other third-party vendors who provide clinical study data to ensure compliance with the protocol, external/internal procedural standards, GCP, applicable regulatory guidelines, company policies, SOPs and other relevant guidelines. Fostering a culture of innovation and continuous improvement in clinical data management practices. Support onboarding of new CDM employees Requirements:&nbsp; BA/BS in life sciences, technical or health-related field, with a minimum of 10 years of pharmaceutical industry experience or CRO with duties of varying complexity.&nbsp; Experience in clinical trial database build, case report form design and familiar with CDISC and regulatory requirements. Excellent oral and written communication skills, project and personnel management skills and organizational skills. Experience in developing, implementing, and overseeing data management plans and quality plans for multiple concurrent research studies. Experience in development of database specifications and build, CRF design, and CRF guideline design, as well as traditional clinical data management systems and/or electronic data capture (EDC) platforms. Understanding and strategic knowledge of FDA and ICH regulations and industry standards applicable to data capture and data management processes. Familiarity with CDISC standards (SDTM, ADaM, CDASH) is required. Familiarity with emerging technologies in clinical research, including AI/ML applications is a plus. Excellent project management, communication, and problem-solving skills. CCDM is strongly preferred Reports to: Sr. Director, Clinical Data Management &nbsp; Location: Remote - US or San Carlos, CA&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $180,000 - $210,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Clinical Data Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our analytical development team. The primary responsibilities for the successful candidate will include method development, sample testing, analyzing data, and authorizing protocols and reports. Essential Functions: Assist in analytical method development of new assays. Perform analytical testing, data analysis and present in team meetings. Maintain thorough and accurate records of laboratory work. Support daily lab operations, sample inventory and sample shipment. Author analytical documents including but not limited to test method, protocols, and reports. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 2+ years of relevant industry experience, or MS with 1+ years of experience. Other combinations of education and/or experience may be considered. Experience in chemical and biological assays such as colorimetric/ fluorometric microplate assays, PCR/qPCR, HPLC, CE, UV-Vis, ELISA and LC-MS. Understanding of basic principles of analytical method development/ validation/ qualification concepts. Attention to detail and excellent skills in record keeping/documentation. Strong interpersonal skills and ability to communicate effectively both verbally and in written formats. This position is a lab-based role and requires onsite presence. Reports to: Senior Scientist, Analytical Development, Raw Materials &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length:&nbsp;12 Months &nbsp; Hourly Range:&nbsp;$51.00 - $56.00 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Analytical Development, Raw Materials (contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Manager, Quality Assurance to support supplier oversight, audit management, and quality systems compliance. This role will lead and perform third-party audits, manage audit responses and CAPAs, and partner with Global Vendor Management and cross-functional teams to support supplier qualification, materials management, and quality agreements. The Manager, Quality Assurance will also contribute to the development and continuous improvement of quality systems and procedures to ensure compliance with cGMPs, regulatory requirements, and internal quality standards. Essential Functions: Audit Program Management Performs third-party audits, including notified bodies, vendor and contract manufacturing organization (CMO) audits, ensuring compliance with quality agreements and regulatory expectations. Lead audit observations response and CAPA implementation, ensuring timely closure and effectiveness verification. Collaborate with Global Vendor Management. Suppliers and Materials Management Involved in the process for new supplier’s introduction. Involved in topics related to materials management such as VCNs (Vendor change notification). Involved in the establishment of Quality Agreements and other required regulatory documentation according to cGMP. Represent QA at internal and external cross functional team meetings related to supplier, services and/or materials. Quality Systems and Compliance Review and approve internal and external documentation for compliance such as deviations, risk assessments, change controls, CAPAs related to supplier, services and/or materials. Develop, implement and maintain procedures and policies related to supplier, services and/or materials topics. Participate in process improvement projects. Interact with key stakeholders to develop solutions to complex issues while promoting quality standards of excellence. Requirements:&nbsp; BS or BA with minimum 5 years of Quality Assurance experience. Other combinations of education and/or experience may be considered. In-depth knowledge of GMPs, FDA/EMA regulations and ICH guidelines. Strong attention to detail. Significant auditing experience ((ASQ certification (CQA, CQE) or auditor certification preferred)). Materials and suppliers’ management experience. Excellent verbal, written, and interpersonal communication skills. Experience leading and contributing through influence and working in cross functional teams. Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Ability to adapt to changing priorities. Strong overall knowledge of biologics manufacturing processes and Quality Systems. Ability to travel up to 40%. Reports to: Sr. Manager, Quality Assurance, Quality Management Systems &nbsp; Location: Visp, Switzerland &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Assurance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Manager Supplier &amp; Internal Auditor to support the Quality Assurance organization through the planning, execution, and management of supplier and internal audits. This role will be responsible for assessing compliance with applicable global regulations, industry standards, and internal quality systems to ensure the integrity of Vaxcyte’s operations and external partnerships. The ideal candidate is a certified auditor with strong working knowledge of GMP, GLP, GCP, ICH, and ISO 13485 requirements and experience auditing within the pharmaceutical, biotechnology, or medical device industries. Essential Functions: Supplier Audits Plan, schedule, and conduct supplier audits (on-site and remote) in support of supplier qualification and ongoing oversight programs. Evaluate supplier compliance with applicable regulations, standards, and contractual quality requirements. Prepare audit agendas, audit reports, and documentation in accordance with internal procedures and regulatory expectations. Review and assess supplier responses to audit observations, including corrective and preventive action (CAPA) plans, and verify effectiveness. Collaborate with cross-functional stakeholders (e.g., Technical Operations, Supply Chain, Regulatory, Quality Systems) to assess audit findings and risk. Internal Audits Execute internal audits of quality systems and operational processes to assess compliance with GMP, GLP, GCP, ICH, ISO 13485, and internal policies and procedures. Support the development and maintenance of the internal audit program, including risk-based audit planning and scheduling. Identify compliance gaps, trends, and opportunities for continuous improvement. Document audit observations clearly and objectively and support follow-up activities to ensure timely and effective remediation. Compliance &amp; Quality Systems Ensure audit activities are conducted in accordance with applicable regulatory requirements and industry best practices. Support inspection readiness by maintaining audit documentation and providing audit support during regulatory inspections as needed. Contribute to the development, review, and improvement of quality procedures related to auditing, supplier management, and compliance. Provide guidance and training to internal stakeholders on audit processes, regulatory expectations, and compliance requirements. Requirements:&nbsp; Bachelor’s degree in Life Sciences or a related field. 5+ years of experience in Quality Assurance, auditing, or compliance within the pharmaceutical, biotechnology, or medical device industry. Other combinations of education and/or experience may be considered. Current auditor certification (e.g., ASQ Certified Quality Auditor (CQA) or equivalent). Strong working knowledge of GMP, GLP, GCP, ICH guidelines, and ISO 13485 requirements. Demonstrated experience conducting supplier and/or internal audits. Strong written and verbal communication skills, with the ability to clearly document audit observations and communicate risk. Excellent organizational skills, attention to detail, and ability to manage multiple audits and priorities. Ability to work independently while collaborating effectively in a cross-functional environment. Ability to travel. Reports to: Sr. Director, Global Quality Management Systems &amp; Compliance &nbsp; Location:&nbsp;San Carlos, CA; Open to remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $153,000 – $178,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Supplier & Internal Auditor

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a talented and experienced Engineer I/II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte. The successful candidate will have the following skills and qualities: Hands-on experience operating and maintaining bioreactors, including Ambr® 250, at laboratory scale. Experience with pilot scale fermentation and recovery equipment is a plus. Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization. An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals. Strong organizational and planning skills. Essential Functions: Lead operational activities related to bioreactor set-up, monitoring, harvest, and maintenance. Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls. Provide engineering support for design, implementation, and qualification of scale-down models. Author SOPs (standard operating procedure), process flow diagrams and batch records. Analyze and present fermentation data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks. Requirements:&nbsp; BS in Chemical Engineering or a related discipline with 8+ years, MS with 4+ years, or PhD with 0-2 years of relevant Pharma/Biotech industry experience. Hands-on experience with fermentation and/or primary recovery unit operations. Good understanding in fundamentals of bioreactor design, operation and controls. Strong knowledge of aseptic techniques Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration, is a plus Understanding of fermentation scale up and development of scale down models Familiarity with DoE (Design of Experiments) principles and software. Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus. Reports to:&nbsp;Senior Scientist, Upstream Development for Protein Development &amp; Manufacturing &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Expected Contract Length:&nbsp;12 months &nbsp; Hourly Range:&nbsp;$62 - $69&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Engineer I, Upstream Development for Protein Development and Manufacturing (Contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: This leadership role is responsible for developing and implementing global regulatory strategies for clinical investigational studies and commercialization of vaccines for both adult and pediatric populations.&nbsp; In collaboration with Clinical Development and Safety this role is responsible for regulatory guidance that enables and facilitates the preparation of clinical development protocols, interpretation and summary of clinical results, initiation, development and preparation of clinical and pre-clinical regulatory documents, correspondence and responses to regulatory authorities toward commercial regulatory approval of novel vaccine products.&nbsp; The role requires experience developing and implementing regulatory strategies for vaccines and preparing investigational and commercial regulatory applications, i.e., IND/IMPD, BLA/MAA, post-approval clinical and safety notifications and global regulatory approvals.&nbsp;&nbsp; Strong communication skills, in particular, the ability to distill complicated issues and regulatory risks and effectively articulate options and opportunities for reconciliation, are essential.&nbsp; The Executive Director must be comfortable with interfaces at all levels of the organization, including senior leadership, Level 1 – 4 multi-disciplinary teams, and with external partners, CDMOs/CROs and regulatory authorities.&nbsp;&nbsp; The ideal candidate possesses a clinical background in vaccine development and relevant experience in development and execution of clinical protocols.&nbsp; Regulatory experience including a thorough understanding of global regulatory requirements and expectations, and the ability to influence and shape regulatory strategies in a dynamic environment is imperative.&nbsp; Strategic vision, attention to detail, and a passion for regulatory excellence are key attributes for success in this position. Essential Functions: Develop and execute globally viable clinical regulatory strategies. Develop, author and review regulatory CMC documentation for submission including application documents, correspondence and responses to queries. This includes requests for scientific advice in EU, Switzerland, UK and Canada, etc.&nbsp; Provide regulatory guidance for L2, L3 and L4 cross functional development teams. Ensure adherence to current regulatory requirements and alignment with appropriate regulatory guidance (including ICH) and industry best practices. Serve as a primary point of contact with regulatory authorities, i.e., FDA, EMA, MHRA, PMDA, Health Canada, etc., as appropriate. Contribute to the development of product label claims and justifications for clinical outcomes. Lead interactions and negotiations w/global regulatory authorities for reconciliation of specific clinical and pre-clinical issues to expedite regulatory application submissions and approvals. Support regulatory requirements for safety/pharmacovigilance notifications to regulatory authorities. Provide guidance on contemporary regulatory intelligence, statutory legislation and changes in regulatory authority requirements and expectations. Manage cross-functional teams to demonstrate and ensure regulatory compliance. Optionally, people development and management may be expected. Requirements:&nbsp; BA or BS in a relevant scientific or technical discipline, i.e., clinical pharmacology, immunology, biology, medicine, bioanalytics or related life sciences, is required with 15+ years industry experience that demonstrates technical and regulatory expertise and competence.&nbsp; Graduate education and/or professional certifications or training in regulatory and/or quality are a bonus. Other combinations of education and/or experience may be considered 10+ years of extensive and relevant regulatory experience with a proven record of achievement in developing and prosecuting regulatory submissions and application approvals within the pharmaceutical or biotechnology industry with a particular emphasis on vaccines and clinical content. A thorough understanding of clinical development, statistics with particular experience with vaccine development and commercialization. Direct experience engaging multiple health authorities, i.e., FDA, EMA, MHRA, Health Canada, etc., and preparation of regulatory applications for global health authorities.&nbsp; Demonstrated ability to lead and manage cross-functional teams, developing and establishing regulatory strategies and preparing regulatory applications including review and submission of clinical and pre-clinical documentation to regulatory authorities. Direct experience developing clinical regulatory strategies and submissions to effectively manage labelling for global markets and post-approval changes and optimizations for commercial vaccines. Demonstrated record identifying clinical and regulatory risks and developing strategies and/or contingencies for mitigation. Experience translating and integrating contemporary regulatory intelligence into appropriate internal policies and practice. Competencies and Skills: Articulate oral and written communication skills Active listening Strategic and tactical critical thinking Constructive operational productivity Adaptability Flexible and optimistic demeanor Reports to: SVP, Regulatory Affairs &nbsp; Location: Remote - US &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $299,000 - $349,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Executive Director, Clinical Regulatory

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Senior Director, Launch Lead, VAX-31, to lead strategic planning and execution of the company’s first launch of VAX-31. This role will coordinate cross-functional activities from late-stage development through market entry, ensuring readiness across supply chain, regulatory, medical affairs, commercial operations, communications, and other functions. The position will partner with senior leadership to define launch strategies, manage timelines, mitigate risks, and drive alignment across internal and external stakeholders to deliver successful product introductions globally. Essential Functions: Drive cross functional launch delivery of VAX-31 and oversee integrated launch plans. Ensure alignment with corporate objectives and market requirements. Develop and maintain comprehensive launch readiness frameworks, including working with supply chain, manufacturing scale-up, regulatory approvals, labelling, distribution, and commercial execution. Partner with Commercial, Medical Affairs, Regulatory, Quality, Manufacturing, Finance, Market Access, and Scientific Affairs teams to ensure seamless coordination and timely decision-making. Facilitate cross-functional launch meetings, track critical milestones, and proactively identify risks and contingency plans. Drive post-launch performance tracking and lessons learned to inform future launches. Champion best practices in pharmaceutical launch project management, including governance models, risk registers, and stakeholder engagement strategies. Requirements:&nbsp; BA/BS in life sciences, engineering, or business; advanced degree preferred. At least 15 years in pharmaceutical or biotechnology industry, with at least 5 years in launch related project management or product marketing/management; vaccine launch experience strongly preferred. Ensure adherence to project scope, budget, and schedule; ensure the alignment of the project to corporate strategic direction, resource allocation, and management decision-making. Facilitate team meetings, cross-functional communication, and decision-making; ensure alignment with internal and external stakeholders, program and project teams and functional area partners. Support continuous improvement efforts in Project Management practices at Vaxcyte. Proven track record of leading successful product launches in multiple markets. Expertise in cross-functional leadership, strategic planning, and risk management for complex launches. Strong understanding of regulatory pathways, supply chain logistics, and market access considerations. Thorough understanding of product development activities in biotech/drug/vaccine development, including key interdependencies, and knowledge of proven development strategies and tactics. Demonstrated strong organizational and strategic leadership skills. Demonstrated aptitude for successfully managing multiple projects, of varying complexity, within the specified guidelines, timeframes, and budgets. Self-starter with the ability to work independently, deal with ambiguity, and execute. Expert planning and tracking skills, well-organized, focused on results, capable of managing multiple projects with respect to priorities and self-management. Proven influence management and communication skills, at all levels of the organization. Expert knowledge of MS Word, Excel, PowerPoint, Visio, and Project. Excellent written and oral communication skills. Other combinations of education and/or experience may be considered. Reports to: Chief Commercial Officer &nbsp; Location: Boston, MA or Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $271,000 - $316,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Product Launch Lead VAX-31

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a Vice President of Marketing to lead our marketing strategy as we prepare to become a U.S. commercial vaccine company within the next 18 months. This role is critical to shaping our U.S. launch, building the marketing foundation for a first commercial product, and positioning the company for future global expansion. The ideal candidate brings deep vaccine marketing experience, a strong understanding of the U.S. immunization landscape, and a proven track record of leading pre-launch and launch activities in a highly regulated environment. This leader will balance strategic vision with hands-on execution, building capabilities, teams, and processes appropriate for a first commercial launch. This individual should have demonstrated experience driving commercial demand across target audiences—including healthcare providers, consumers/patients, payers, and public health stakeholders—with a particular emphasis on consumer engagement strategies that build disease awareness and motivate vaccination behavior. Essential Functions: U.S. Launch &amp; Commercial Strategy Lead the development and execution of the U.S. marketing strategy for our initial vaccine launch, including disease awareness, brand positioning, and go-to-market planning. Develop differentiated value propositions grounded in clinical data, public health impact, and real-world evidence. Partner closely with the Chief Commercial Officer to align marketing strategy with overall commercial, sales, and market access plans. Vaccine &amp; Immunization Expertise Apply deep understanding of the U.S. vaccine ecosystem, including immunization schedules, CDC/ACIP considerations, public health stakeholders, and provider types. Design marketing strategies that address the unique dynamics of vaccine adoption, including site-of-care complexity, and public trust. Collaborate with Medical Affairs and Regulatory to ensure compliant, scientifically sound communications. Partner with Government Affairs and Policy teams to ensure marketing strategies account for evolving immunization policy, public funding mechanisms, and advocacy stakeholder dynamics. Collaborate with HEOR and Market Access to develop evidence-based value narratives and payer-facing materials that support formulary positioning and access. Brand &amp; Portfolio Marketing Establish the company’s commercial brand and narrative as we transition from a development-stage biotech to a commercial organization. Lead brand development, messaging, and omnichannel promotional strategy across HCP, payer, and patient audiences. Design and execute integrated omnichannel engagement strategies spanning personal promotion, digital channels, and non-personal promotion to optimize customer reach, frequency, and impact across the vaccine adoption journey. Develop digital-first engagement models for hard-to-reach HCP segments, including pharmacists and public health practitioners critical in vaccine delivery. Develop and execute consumer/patient engagement strategies—including disease awareness campaigns, direct-to-consumer (DTC) advertising, and health literacy initiatives—that drive vaccination demand at the population level. Build multi-audience demand generation strategies that create a pull-through effect across HCPs, consumers, payers, employers, and public health decision-makers to maximize vaccine adoption. Partner with Patient Advocacy organizations and community health stakeholders to inform patient-centric messaging and overcome barriers to vaccination, including vaccine hesitancy and health equity gaps. Develop lifecycle and indication expansion strategies to support future growth and pipeline advancement. Market Insights &amp; Analytics Lead market research, customer insights, and competitive intelligence to inform launch readiness and ongoing optimization. Define KPIs and performance metrics to measure marketing effectiveness and launch success. Leverage data analytics and AI-powered tools to enhance competitive intelligence, identify prescriber behavior patterns, and inform real-time marketing optimization decisions. Team, Infrastructure &amp; Capability Building Build and lead a high-performing marketing organization, scaling the team and capabilities over time. Establish agency partnerships and external vendors to support launch execution. Build and manage a high-performing agency roster with clear scopes of work, performance metrics, and governance structures that drive accountability and cost efficiency. Implement marketing processes, governance, and operating models consistent with U.S. commercial and regulatory requirements. Implement marketing operations infrastructure including project management systems, digital asset management (DAM), and content supply chain processes designed for scale and speed-to-market. Own the marketing budget, ensuring disciplined resource allocation across brand, digital, and promotional investments with clear ROI measurement and launch investment frameworks. Future Global Expansion Design U.S. marketing strategies with future global scalability in mind. Partner cross-functionally to support early planning for potential international expansion, including global brand frameworks and knowledge transfer. Digital Innovation &amp; AI-Enabled Marketing Champion the integration of AI and emerging technologies into marketing workflows to improve quality, speed, cost efficiency, and decision-making across the marketing organization. Evaluate and deploy AI-powered tools for content creation, personalization, competitive intelligence, and customer engagement—ensuring all applications comply with regulatory and MLR requirements. Leverage generative AI to accelerate content development cycles, enable omnichannel personalization at scale, and streamline the Medical-Legal-Regulatory (MLR) review process. Establish an AI-informed marketing operations model that uses predictive analytics to optimize targeting, message sequencing, and media mix allocation. Identify opportunities to use AI and automation to reduce agency costs, accelerate time-to-market for promotional materials, and improve ROI across marketing investments. Partner with IT, Data Science, and Commercial Operations to build a connected, data-driven marketing ecosystem from the ground up. Requirements:&nbsp; Bachelor’s degree required; advanced degree (MBA, MS, PhD) preferred with 15+ years of progressive marketing experience in biotech or pharmaceuticals. Other combinations of education and/or experience may be considered Significant experience in vaccine marketing, including U.S. launch experience. Demonstrated success leading pre-launch and first-launch marketing efforts. Preferred Qualifications: Experience building a marketing organization in a pre-commercial or first-launch biotech environment. Track record of leading omnichannel marketing strategies integrating digital, non-personal, and field-based promotion. Experience managing complex agency rosters and marketing vendor ecosystems across creative, media, digital, and analytics functions. Familiarity with AI/ML applications in marketing, including content generation, customer segmentation, predictive analytics, and campaign optimization. Demonstrated fluency in marketing analytics, including KPI frameworks, attribution modeling, and data-driven optimization. Experience with MLR processes and demonstrated ability to partner effectively with Medical and Legal/Regulatory in a compliant promotional environment. Strong executive presence with the ability to influence C-suite stakeholders and represent the marketing function on cross-functional leadership teams. Proven experience driving commercial demand generation across both HCP and consumer/patient audiences in a regulated healthcare environment, including DTC, disease education, or unbranded awareness campaigns. Public health marketing or disease awareness campaign experience preferred Reports to:&nbsp;Chief Commercial Officer &nbsp; Location: San Carlos, CA / US Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $315,000 - $385,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Vice President, Marketing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is undergoing a major ERP transformation, moving to SAP S/4HANA to support its rapid growth and upcoming transition to Commercial Operations. The IT SAP Supply Chain Senior Business Systems Analyst (BSA) will play a critical role in bridging Supply Chain and IT, ensuring successful implementation, stabilization, and ongoing optimization of SAP S/4HANA Supply Chain capabilities. This position requires strong functional expertise in SAP Supply Chain functionalities, deep understanding of contract manufacturing processes, and experience in complex ERP implementation projects. Essential Functions: Support the implementation and stabilization of SAP S/4HANA Supply Chain modules in a regulated environment. Collaborate with Supply Chain, Manufacturing, Quality, and IT teams to design future-state processes aligned with Vaxcyte's CDMO business model. Assist in data mapping, migration, cleansing, and validation during cutover and post-go-live activities. In-depth knowledge of SAP S/4HANA systems and integration techniques with third-party planning systems. Expertise with agile methodology, global deployments, and data migration planning. Experience working in GxP validated and SOX regulated systems. Configure and maintain SAP Supply Chain modules including Materials Management (MM), Master Data, Subcontracting &amp; External Processing, Batch Management, and Forecast Consumption &amp; Demand Planning. Assist with the integration points with FI (Financial Accounting) &amp; CO (Controlling) Support end-to-end planning flows from demand through manufacturing and supply execution. Excellent verbal and written communication skills, with the ability to effectively communicate complex technical concepts to non-technical stakeholders. Work closely with Supply Chain stakeholders (Planning, Procurement, Finance) to capture requirements. Translate business needs into functional specifications for SAP configuration. Help develop and document business process flows. Support complex planning scenarios where capacity, lead times, and execution are controlled by external CDMO partners. Develop and execute test plans for SAP Supply Planning processes. Support User Acceptance Testing (UAT) and resolve issues promptly. Ensure validation readiness and maintain audit trail expectations in compliance with regulatory requirements. Training &amp; Change Management Create training materials and deliver sessions for Supply Chain users. Provide ongoing support post go-live. Ensure compliance with GxP standards and Life Sciences industry requirements. Requirements:&nbsp; Minimum of 7 years of experience as a BSA with SAP Supply Chain modules. Bachelor's degree in Supply Chain, Operations, Information Systems, or related field Strong analytical and problem-solving skills, with the ability to independently diagnose and resolve SAP supply chain issues in complex CDMO-based manufacturing environments. Experience in identifying and managing project risks, with a proactive approach to mitigation. Familiarity with change management principles and techniques to facilitate smooth transitions and adoption of new systems. Hands-on experience with SAP S/4HANA Supply Chain (implementation or migration projects preferred) and Fiori applications. Proven experience supporting SAP-based contract manufacturing or CDMO operating models. Experience developing and mapping business process flows using Visio or similar tool. Strong understanding of Supply Chain processes and ERP implementation best practices. Excellent communication and stakeholder management skills. Solid experience managing SAP master data relevant to supply planning (materials, vendors, sourcing, BOMs). Other combinations of education and/or experience may be considered. Reports to: Director, IT Supply Chain Systems &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior IT Business Systems Analyst, SAP Supply Chain

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Director, Real-World Evidence &amp; Epidemiology to play a foundational role in executing, expanding, and maturing our epidemiology and real-world evidence (RWE) capabilities across the vaccine lifecycle. You will join a purpose-driven team advancing the science of prevention across the life course. This role offers a rare opportunity to help build an epidemiology and real-world evidence function from the ground up, with meaningful ownership, mentorship, and room to grow. This is a hands-on, high-impact role well-suited for an early-to-mid career epidemiologist who enjoys both doing the work and building the function. The role combines operational leadership (study start-up, vendor oversight, IRB submissions) with scientific execution, including study design, analysis, evidence synthesis, and interpretation. Over time, this individual will grow into a scientific epidemiology lead, taking on increasing ownership of study design, analytic strategy, and external scientific engagement. Essential Functions: Study Execution &amp; Operations Lead end-to-end execution of epidemiology and RWE studies, including retrospective database studies, prospective observational studies, and hybrid designs, supporting both pediatric and adult vaccine programs. Manage study start-up activities including contracting, budgets, timelines, and SOWs with CROs, academic partners, and data vendors. Oversee IRB and ethics submissions and ensure compliance with regulatory, privacy, and data governance requirements. Partner closely with Legal, Procurement, and Compliance to ensure timely and compliant study execution. Epidemiologic &amp; Analytic Contributions Contribute to study design, protocol development, and statistical analysis plans in collaboration with internal scientific partners. Conduct or oversee hands-on analyses using real-world data sources (e.g., claims, EHR, surveillance systems), including data quality checks and exploratory analyses. Support and/or lead retrospective analyses, prospective cohort studies, systematic literature reviews, and meta-analyses relevant to pneumococcal disease and vaccine effectiveness across age groups. Work with large datasets and analytic tools (e.g., SAS, R, STATA) to support internal analyses and to critically review and interpret CRO-generated outputs. Evidence Synthesis &amp; Scientific Communication Lead or contribute to abstracts, manuscripts, white papers, and conference presentations. Translate complex scientific and epidemiologic findings into clear, actionable insights for diverse internal audiences, including commercial partners, medical science liaisons, HEOR, legal, and regulatory teams. Support consistent, high-quality interpretation of evidence across Vaxcyte’s epidemiology and RWE portfolio. Capability Building &amp; Growth Help establish best practices, templates, and SOPs for epidemiology and RWE study conduct. Build strong working relationships with academic collaborators, public health partners, and external vendors. Gradually assume greater scientific leadership and ownership of the epidemiology portfolio as the function grows. Requirements:&nbsp; Master’s degree in Epidemiology, Public Health, Biostatistics, or a closely related field, with 8 years of experience in epidemiology, real-world evidence, or observational research within biotech, pharma, academia, public health, or a CRO required. PhD or DrPH in Epidemiology or a related discipline with 6 years experience preferred. &nbsp;Other combinations of education and/or experience may be considered. &nbsp; Demonstrated experience planning and executing observational studies, including retrospective and/or prospective designs. Experience working with real-world data and analytic tools (e.g., SAS, R, STATA), including data management, analysis, or close oversight of analyses. Ability to clearly present complex scientific and epidemiologic data to non-technical audiences, both verbally and in writing. Strong scientific judgment, organizational skills, and ability to independently manage multiple workstreams in a fast-paced environment. Highly desired experience: Prior experience at the CDC, including Epidemic Intelligence Service (EIS) or similar applied epidemiology training programs. Experience conducting or contributing to systematic literature reviews and meta-analyses. Experience working with large healthcare databases (e.g., claims, EHR, surveillance systems). Prior experience in vaccine research, infectious disease epidemiology, or respiratory disease. Track record of contributing to peer-reviewed publications and major scientific meetings. Prior experience with health economic modeling Interest in growing into a scientific leadership role within industry. Reports to: Vice President, Scientific Affairs &amp; Epidemiology &nbsp; Location: San Carlos, CA/ Remote (East Coast Region)&nbsp; &nbsp; Compensation:&nbsp; The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $199,000 – $232,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Real-World Evidence & Epidemiology

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our Analytical Development team as a contractor. Primary responsibility for the contractor will be to support the developmental activities currently on going in the laboratory as assigned. Essential Functions: Maintain an organized and efficient laboratory workspace for the team. Primary responsibility to oversee the organization of chemical inventory, ensuring proper labelling, storage, and compliance with safety regulations. Assist in the organization and labelling of materials stored in freezers and refrigerators, ensuring easy access, proper storage and handling of samples and materials. Support daily lab operations, including sample inventory and sample shipment. Assist in the collection, labelling, and preparation of samples for analysis. Prepare reagents and solutions according to established protocols. Perform routine analytical testing by following established protocols, ensuring accurate execution of tests and documentation for proteins and carbohydrates including: Microplate assays including enzymatic assays and colorimetric assays such as Bradford, Lowry and etc HPLC- Especially SEC and RP-HPLC with experience in Chemstation CE and iCIEF – Especially with Protein Simple or PA-800 systems Keep accurate and detailed records of experiments. Maintain an accurate inventory of chemicals and reagents, tracking usage and expiration dates. Coordinate the ordering and restocking of laboratory supplies as needed. Perform routine analytical testing by following established protocols, ensuring accurate execution of tests and documentation. Collaborate within a team environment to support and further team objectives. Demonstrate flexibility and effectively complete assigned tasks with high quality and in a timely manner. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 0-2 years of relevant industry experience. Experience with lab inventory chemical inventory, ensuring proper labelling, storage, and compliance with safety regulations Ideal candidate will have a background in analytical chemistry principles and hands-on experience with modern analytical instrumentations commonly used in the analysis and characterization of drug candidates. Candidates with other scientific disciplines may be considered based on relevant experience. Experience in chemical and biological assays such as colorimetric/fluorometric microplate assays and HPLC. Experience working with protein analysis – UV-Vis, CE, Bradford Assay or ELISA. Understanding of basic principles of analytical method development/ validation/ qualification concepts. Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data. Strong interpersonal skills: ability to communicate effectively both verbally and in written formats. Ability to work under supervision and independently in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease. Reports to: Manager, Analytical Development &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Expected Contract Length: 6months &nbsp; Hourly Range: $40.00/hr. – $45.00/hr. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist I (contract), Analytical Development for Characterization

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Scientist II (contract), Research, to support the research and development of a novel bacterial polysaccharide conjugate vaccine. Specifically, this role will contribute to the setup, synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates.&nbsp; The ideal candidate will have an excellent understanding of conjugation process development, analytical chemistry principles, and substantial hands-on laboratory experience. The successful candidate will be expected to independently optimize and troubleshoot upstream and downstream conjugation processing procedures with minimal guidance. The candidate will also contribute across a range of related areas, including analytical development, stability studies, and process optimization initiatives. Responsibilities will also include record management, presenting data at group meetings, and contributing to the authorship of laboratory protocols and development reports. Essential Functions: Set up, optimize, and troubleshoot multi-step syntheses of protein-polysaccharide conjugates using click-chemistry and other related chemistries. Purify polysaccharides and conjugates using a variety of methods, including dialysis, FPLC chromatography, and tangential flow filtration (TFF). Characterize protein/polysaccharide/conjugates using different analytical methods, including SDS-PAGE gel, Western blotting, ELISA, HPLC, SEC-MALS, colorimetric and dynamic binding assays, et al. Apply Design of Experiments (DoE) principles; design, execute, and interpret statistically modeled experiments using DoE software. Proactively contribute scientific ideas, experimental strategies, and process improvements. Independently review and summarize relevant scientific literature to inform experimental design. Maintain highly organized records and Benchling entries to enable optimization and assessment of reproducibility. Analyze, interpret, and clearly communicate experimental data, including identifying trends, anomalies, and recommending next steps. Execute established protocols with limited oversight, demonstrating strong technical proficiency. Support team in routine laboratory activities and instrument maintenance. Requirements:&nbsp; BS. in Chemistry, Biochemistry, or related field or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience. Strong understanding of underlying scientific concepts, process development, and analytical assay principles. Extensive hands-on experience in purification methods such as diafiltration, depth filters, and TFF (required). Prior hands-on experience in the conjugation process development is highly desirable. Proficiency with common protein/polysaccharide/conjugates analytical techniques, including SDS-PAGE, Western blotting, ELISA, HPLC, and SEC-MALS, is required Proven track record of developing scalable processes suitable for the pharma/Biotech industry. Experience with vaccines, carbohydrates, or protein is a plus. Attention to detail and excellent organizational skills. Ability to contribute to the overall lab management, including organization of vendors, service contracts, and equipment maintenance. Demonstrated success working in a cross-functional team environment. Strong interpersonal skills, with excellent written and verbal communication skills. Reports to: Senior Manager, Research &nbsp; Location: San Carlos, CA Expected Contract Length: 12months&nbsp; Hourly Range:&nbsp;$51.00 - $56.00 We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II (Contract), Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Research team uses a broad palette of chromatographic tools to purify diverse vaccine antigens. Applicants must have practical, hands-on experience with multiple chromatographic modalities (not limited to monoclonal antibody/Protein A workflows). Experience should include selection, screening, development, scale-up and characterization of various chromatography techniques. Essential Functions: Execute the following AKTA FPLC chromatography techniques: Immobilized metal affinity chromatography (IMAC) Ion-exchange chromatography (IEX) Hydrophobic interaction chromatography (HIC) Size-exclusion chromatography (SEC) Hydroxyapatite (CHT / HA) Designing chromatography trains to reduce host cell protein, endotoxin and aggregates using complementary modalities Demonstrated DoE experience for multimodal optimization is a plus. Membrane chromatography for high-throughput contaminant removal or virus/VLP processing and as a scale-friendly polishing/scavenging step. Keep accurate and current records of development experiments and/or project related activities in an electronic laboratory notebook. Present data from experiments to the team and contribute to technical discussions. Work within a team environment and provides support as necessary to further the team’s initiatives. Requirements:&nbsp; BS in Biochemistry, Molecular Biology or a relevant science considered, with minimum of 5 years of relevant industry experience or MS with minimum of 3 years relevant industry experience. Experience with diverse protein targets, bacterial and eukaryotic recombinant proteins, small/large subunit vaccine antigens, fusion proteins, multimeric complexes, glycoproteins, and VLPs. The role requires demonstrated success with alternative capture/polishing methods and orthogonal cleaning strategies appropriate for potential vaccine antigens. Preferred experience with Cell-free protein synthesis system Familiarity with automation or high throughput workflows such as (96-well plates) and UNICORN/AKTA software DoE integrations. Experience in process development Strong interpersonal skills to collaborate well within the team and excellent written and verbal communication skills. Reports to: Scientist I, Research &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12months &nbsp; Hourly Range: $56.00 – $62.00We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist (contract), Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Veeva Configuration Specialist IT role serves as a techno-functional expert for Vaxcyte’s current and future Veeva applications and related technologies. Working closely with business and managed services partners, this role is responsible for implementing, managing, and maintaining Quality, Regulatory and Clinical Veeva Vault system configurations. While technical in nature, this role drives business value by blending technology expertise with business process know-how. This is a hands-on role that reports to the Associate Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters. Essential Functions: Customize and configure Veeva Vault applications to meet business requirements. This includes creating/updating custom doc types, objects, lifecycles, workflows, jobs, user roles, security management, reports and vault loader. Provide Veeva admin and operational support for issues impacting end-users, system unavailability, data integrity, and manage user account provisioning. Create and maintain system-specific IT documentation such as configuration forms, business processes, operating procedures, templates and design standards Establish and maintain close working relationships with internal Veeva business partners. Collaborate with stakeholders to understand current business processes and identify areas for improvement and optimization. Lead requirements gathering, analysis, design, and configuration activities. Assess impact and configure new features available after each Veeva release. Provide project management support for enhancement efforts. Follow GxP change management processes for system configuration changes and platform upgrades. Support periodic reviews and related compliance activities. Coordinate with managed services, business partners and assurance teams to implement planned releases and functional change requests. Requirements:&nbsp; Bachelor’s degree in computer science, information systems, or related field. Mandatory 3+ years of hands-on configuration experience with any Veeva Vault Platform systems. 5- 7 years of total IT Systems experience. Strong understanding of Veeva application suites including Quality (QualityDocs, QMS, Vault Training), RIM and Clinical eTMF. Experience with validated GxP environments including implementation, documentation and change management is a must. Extensive experience as a business systems analyst for Enterprise IT systems. Veeva system administration certification is a plus. As is/to be process mapping and analysis. Solid problem-solving skills and ability to troubleshoot issues including root cause analysis. Excellent communication skills and ability to work collaboratively with stakeholders. Technical writing skills for updating SOPs, WIs, Knowledgebase articles and documenting business processes. Reports to:&nbsp;Associate Director, IT Enterprise Systems &nbsp; Location: San Carlos, CA; Ability to be on-site 2 or 3 days per week &nbsp; Expected Contract Length:&nbsp;6 months &nbsp; Hourly Range:&nbsp;$66.38 - $77.45 (SF Bay Area). Hourly ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Veeva Configuration Specialist (Consultant)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Manager, Quality Assurance, Drug Product will play a critical role in ensuring the quality, safety, and compliance of commercial vaccine products. This leader will oversee QA activities related to manufacturing, batch disposition, deviations, and risk management, while actively participating in audits and continuous improvement initiatives. The ideal candidate brings extensive QA experience in the biotech or pharmaceutical industry, strong leadership skills, and the ability to partner effectively across functions to support a culture of quality. Essential Functions: Provide Quality Assurance oversight of Contract Manufacturing Organizations. Represent QA at internal cross functional team meetings and at Joint Project Team meetings. Lead batch disposition activities such as review of executed batch records, environmental monitoring and quality control data. Review and approve documentation such as master batch records, deviations, risk assessments, change controls, and CAPAs. Lead deviation and product complaint investigations Drive resolution of quality performance issues with the contract manufacturer. Support validation activities. Identify opportunities to streamline QA processes and systems Champion initiatives to enhance quality culture and operational excellence across the organization. Interact with key stakeholder to develop solutions to complex issues. Participate in compliance audits as required (health authority and contract manufacturer) Promote a quality mindset and quality excellence approach to all activities. Mentor and coach QA staff to strengthen technical capabilities and regulatory compliance mindset. Requirements:&nbsp; Bachelor’s degree in Chemistry, Biology, Pharmacy, Engineering, or a related field. Minimum of 8 years of experience in quality assurance, batch record review, manufacture, or quality systems management within the pharmaceutical, biotechnology, or life sciences industry. Other combinations of education and/or experience may be considered. Strong knowledge of cGMP, ICH guidelines, FDA/EMA regulations, and other international pharmaceutical quality standards. Knowledge and experience in Risk Management principles. Experience in both clinical and commercial parenteral drug product required. Strong Management and process improvement skills. Demonstrated experience managing batch record review, deviations and change management. Demonstrate experience in annual product reports Great organization skills and have an attention to details. In-depth understanding of aseptic manufacturing (biologics) operations. Ability to prioritize multiple assignments and changing priorities. Excellent problem-solving skills and the ability to manage complex investigations and root cause analyses. Strong written and verbal communication skills, with the ability to clearly present quality issues to cross-functional teams. Reports to: Director, Quality Assurance, Drug Product &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $166,000 – $193,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Assurance, Drug Product

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Manager for Drug Substance (DS) Commercialization has the responsibility for launch readiness and commercial supply of the conjugate drug substance. The conjugate product strategy will transition from the Process Development organization to Manufacturing Science and Technology (MSAT) during late-stage product development.&nbsp; This role focuses on technical launch planning and execution by bringing best-practices and coordinating cross-functional efforts for regulatory filings, facility readiness, and launch supplies. This role also provides leadership to ensure that the organization is equipped to effectively communicate the scientific and commercial rationale for conjugation process to internal stakeholders, relevant CMOs, and to regulatory agencies. The incumbent will be highly skilled in written communication, especially in regard to authoring Health Authority submissions (IND/BLA). The role will also require the ability to interact effectively with people of diverse backgrounds and perspectives. The incumbent will also work with the organization to ensure on-time execution and appropriate planning for commercial lifecycle management. This position will be reporting into the Director for Global DS Commercialization, Conjugation. The Sr. Manager will collaborate on overall program strategy, with primary responsibility and accountability for the drug substance strategy.&nbsp; Manufacturing Science and Technology (MSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. As part of the Commercial Manufacturing and Supply Chain organization, MSAT will lead the technical and process support for end-to-end commercial manufacturing, including Polysaccharides, Carrier Proteins, Conjugation across all Drug Substances (DS). The range of activities will include DS technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, and investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle etc.&nbsp; Essential Functions: DS Commercialization – Provide strategic and scientific leadership for polysaccharide to protein conjugation with internal and external stakeholders and ensure successful execution of launch plans and post-launch commercial activities. Organization – Build a strong and highly-skilled team for the global network with special focus on manufacturing processes. Support resourcing recommendations on staffing requirements to meet organizational goals. Process robustness – Continuously improve process understanding and process robustness by putting systems in place to monitor, trend, and optimize operations. Interface - Collaboration with cross-functional teams across the network, including Regulatory, CMC, Quality, Supply Chain, Procurement, and Process Engineering, to drive the successful development and commercial launch of the conjugate drug substance. Provides technical representation into initial technology transfer, product launch, product lifecycle, to the end of life/product retirement and for defining/developing the next generation of production technologies. Tech-transfer new technologies - Ensure robust processes exist to support technical transfers and integration of new technologies. Support technical services - Support of our internal and external manufacturing network, including materials management and data analytics. Process validation and comparability - Provide support for the execution of process validation and process comparability activities. Regulatory - Engage In technical reviewing and authoring of regulatory filings and responding to questions received from health authorities. Effectively communicate the scientific and commercial rationale for DS processes to the Boards of Health for regulatory submissions for commercialization. Communicate - Effectively and efficiently communicate process performance to key stakeholders (internal-facing and external-facing). Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Executing for Results - Set clear and challenging goals and take accountability for driving results. Comfortable with ambiguity and uncertainty; the ability to adapt nimbly and lead others through complex situations. Leadership - Contribute with the DS Commercialization lead and as member of the Global Manufacturing Operations, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Delegate effectively, celebrate diversity within the team, and manage team performance with a strong focus on colleague development. Travel - 10-30% travel required. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 5+ years of relevant experience for Ph.D., 8+ years for M.S./M.A., or 12+ years for B.S./B.A. Experience in development, tech transfer, scale-up or production of polysaccharide/protein conjugate vaccines Experience in MSAT or Process Development in supervisory and/or matrixed team roles. Able to leverage deep technical knowledge in a collaborative manner to achieve collective goals. Excellent organization, problem solving and strategic planning skills. Highly skilled in both verbal and written communication, especially in regards to authoring Health Authority submissions (IND/BLA) with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges, and independently identifies and implements effective steps and solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Director, Global MSAT Commercialization Lead, Conjugation &nbsp; Location: San Carlos, CA or North Carolina&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $165,000 – $193,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Global Drug Substance Commercialization, Conjugation

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director, Business Operations (Global QC) will lead the strategic design, implementation, and continuous optimization of global operational frameworks supporting Vaxcyte’s Quality Control (QC) and supporting Analytical interfaces. This role ensures that analytical inputs and QC operations are scalable, compliant, efficient, and aligned with corporate and regulatory expectations as the organization advances from development through commercial readiness. The Director will serve as the central business operations leader for the Global Quality Control, partnering with leaders in Analytical Development, Analytical Science &amp; Technology, Stability, Process Development, Manufacturing Science and Technology (MS&amp;T), and Quality. This individual will drive governance, process standardization, infrastructure development, and cross-functional coordination to enable timely, compliant, and uninterrupted supply of Vaxcyte’s innovative vaccines. Essential Functions: Operational Excellence &amp; Strategy• &nbsp; &nbsp;Lead the design and execution of operational strategies that translate Vaxcyte’s global vision into efficient, compliant, and scalable QC and analytical business operations.• &nbsp; &nbsp;Develop and maintain a global QC operations strategy, ensuring alignment with clinical and commercial objectives.• &nbsp; &nbsp;Implement continuous improvement frameworks (e.g., Plan-Do-Check-Act) to enhance efficiency, scalability, and compliance across analytical and QC processes.• &nbsp; &nbsp;Define and monitor key performance indicators (KPIs) that assess operational performance, quality, delivery timelines, and cost efficiency across the global analytics network.• &nbsp; &nbsp;Partner with cross-functional leaders to ensure analytical and QC infrastructure, systems, and processes are integrated into overall business objectives.• &nbsp; &nbsp;Lead initiatives that improve operational automation, data visibility, and process robustness. Governance &amp; Compliance• &nbsp; &nbsp;Establish and maintain robust governance frameworks for QC and analytical operations in alignment with global cGMP regulations and internal quality standards.• &nbsp; &nbsp;Define, visualize, and formalize QC business processes using RASCI principles, ensuring clear ownership and accountability across the analytical network.• &nbsp; &nbsp;Review and enhance the Quality Management System (QMS) infrastructure to close gaps, harmonize SOPs, and strengthen procedural consistency.• &nbsp; &nbsp;Ensure data integrity principles are embedded in all operational practices, compliant with Vaxcyte’s DI policies and global standards.• &nbsp; &nbsp;Support global inspection readiness and lead preparations for regulatory inspections, partner audits, and customer reviews.• &nbsp; &nbsp;Collaborate with Quality to ensure analytical operations and contract testing laboratories meet all compliance requirements. Infrastructure &amp; Systems Leadership• &nbsp; &nbsp;Oversee the development and validation of business systems, data management platforms, and documentation practices across global analytical and QC sites.• &nbsp; &nbsp;Ensure that contract and in-house laboratories maintain robust equipment qualification, calibration, and maintenance programs to support reliable analytical testing.• &nbsp; &nbsp;Lead network and site planning activities, including external partnerships and outsourcing strategies with CDMOs and CROs.• &nbsp; &nbsp;Develop business cases for laboratory expansion, outsourcing scenarios, and infrastructure investments to support strategic growth. Capability Building &amp; Team Leadership• &nbsp; &nbsp;Collaborate and mentor a global team of QC operations professionals to ensure scientific, technical, and operational excellence.• &nbsp; &nbsp;Drive training programs that enhance technical proficiency, compliance culture, and cross-functional understanding within the analytics organization.• &nbsp; &nbsp;Foster a culture of innovation, learning, and continuous improvement across the analytical network.• &nbsp; &nbsp;Collaborate closely with functional heads across Analytical Development, Analytical Science and Technology, Stability, and Manufacturing to harmonize operational practices.• &nbsp; &nbsp;Represent Global Analytics and QC Operations in governance bodies, steering committees, and cross-functional business forums. Requirements:&nbsp; • &nbsp; &nbsp;Bachelor’s or Master’s degree (or higher) in Biotechnology, Pharmaceutical Sciences, Engineering, or related field.• &nbsp; &nbsp;12+ years of progressive experience in Quality Control, Analytical Operations, or Technical Operations within a biotechnology or pharmaceutical company.• &nbsp; &nbsp;Demonstrated leadership in developing and managing operational systems in GMP-regulated environments.• &nbsp; &nbsp;Strong understanding of cGMP, global regulatory requirements, and analytical testing operations.• &nbsp; &nbsp;Proven ability to design and implement business processes, governance models, and performance management systems.• &nbsp; &nbsp;Experience with vendor management and collaboration with CDMOs/CROs on analytical testing and QC operations.• &nbsp; &nbsp;Exceptional communication, negotiation, and relationship-building skills with internal and external stakeholders.• &nbsp; &nbsp;Strong analytical, organizational, and problem-solving skills; adept at data-driven decision-making.• &nbsp; &nbsp;Demonstrated passion for process improvement, operational efficiency, and automation Reports to: Head of Quality Control &nbsp; Location: Visp, Switzerland Compensation:The compensation package will be competitive and includes an equity component. Relocation:&nbsp;This role is not eligible for relocation assistance.&nbsp; We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Business Operations (Global Quality Control)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an experienced and collaborative-minded Senior Director (or Director DOE) of Procurement to join our team.&nbsp; This individual will be responsible for owning and leading the enterprise Procurement function and procurement strategy, and for managing and scaling the team that focuses on indirect purchasing, policy, business process, and systems enablement.&nbsp; The key purchasing pillars of this Director’s scope of responsibility include enterprise-wide ownership of all non-inventory related sourcing and procurement activities, including clinical, sales &amp; marketing services, travel, and professional services with accountability for governance, compliance, and value creation across these categories. This individual will be responsible for helping the organization grow while balancing cost, risk, scalability, and speed of execution, and will serve as a key advisor to Finance and business leaders on sourcing trade-offs and procurement-related risk. We are looking for a savvy professional who is adept at strategizing, coordinating, and planning, and who can define and implement improvements in policies, processes, and procedures to enable the company’s growth. This individual will have a customer service mindset and partner closely with internal stakeholders to clarify business needs, strengthen vendor relationships, and source new suppliers capable of supporting a transition to a commercial-stage organization.&nbsp; A successful candidate will bring an enterprise mindset, the ability to design and implement right-sized tools and processes, and the flexibility to adapt to evolving business needs through pragmatic and innovative problem solving. &nbsp; This individual will manage a team of approximately 5–7 professionals and will be responsible for scaling the procurement organization over the next 2–3 years, including organizational design, talent development, performance management, and succession planning, to build a high-performing and sustainable function. &nbsp; Essential Functions: Own and govern procurement policies, procedures, and programs, and identify opportunities to enhance organizational value, efficiency, and compliance. Establish and oversee enterprise-wide procurement guidance, training, and escalation pathways for our business partners across all departments. Define and lead all strategic purchasing activities in support of research, lab operations and supplies, clinical, and other non-inventory categories, including professional services, outsourced providers, and contingent workforce planning. Establish consolidated supplier spend information and insights and create and manage operational performance metrics for procurement processes. Provide strategic oversight, guidance, and final approval for high-impact, high-risk, or complex negotiations to obtain optimal pricing and contract terms. Oversee and ensure best-in-class execution of sourcing (RFx) events across categories including, but not limited to, lab supplies, lab equipment, Facilities, IT, and MRO/CROs. Identify opportunities to consolidate vendors to achieve volume discounts, cost reduction opportunities and optimal terms. Collaborate with Technical Operations, Clinical, Commercial, IT, Legal and other key business functions to enable enterprise-wide supplier management. Ensure proper adherence to purchasing and contracting workflows. Work closely with accounting operations teams, FP&amp;A and accounts payable to resolve issues with purchase order and invoice discrepancies, ensuring proper internal controls and SOX compliance are in place. Evaluate, select, and implement procurement systems and tools, establishing a scalable roadmap for automation and integration with Finance and ERP systems. Work closely with FP&amp;A in developing or updating budgets and forecasts. Work closely with the company legal department to make sure contracts and terms are favorable. Ensure appropriate oversight of vendor setup, documentation, and diligence (e.g., W-8, W-9), delegating execution while maintaining accountability for compliance and a customer service orientation of the team. Coach, mentor and develop a high performing team. Other responsibilities as needs arise. Requirements:&nbsp; Bachelor’s Degree in Business Administration or related field is required. Minimum 14 years of progressive experience in procurement, strategic sourcing, or supply management within a biotech, life sciences, or pharmaceutical environment with owned laboratory facilities. Other combinations of education and/or experience may be considered. &nbsp; Demonstrated experience leading procurement organizations with significant indirect spend, complex vendor portfolios, and cross-functional stakeholders. ~10 of experience in a publicly traded company with strong appreciation for SOX controls, audit requirements and diligence in a public company setting ~7 years as a proven leader managing teams and supporting their development, training and goal achievement Demonstrated ability to identify and implement process improvements to purchasing workflows, P2P and S2P processes, including experience working effectively within cross-functional governance frameworks. Experience operating in ERP-enabled environments (e.g., NetSuite, SAP S/4HANA), with a strong understanding of procurement controls, system workflows, and audit implications Strong executive presence and the ability to influence and partner effectively with senior leaders Independent self-starter and a proactive individual with a drive to achieve goals and solve problems, sometimes without similar precedents. Ability to work in the HQ office 3-5 days a week Reports to: Sr. Vice President, Finance &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $257,000 - $300,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Procurement

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an opportunity for a Senior Project Manager to manage complex, cross‑functional initiatives focused on IT, Finance, and Laboratory Systems implementations, ensuring smooth delivery across planning, requirements, system design, testing, deployment, training, and change management. This leader partners closely with finance teams, scientific/lab operations, IT, and vendors to deliver technology solutions that improve data integrity, operational efficiency, and strategic decision‑making.The ideal candidate brings substantial experience managing systems implementations, a deep understanding of financial and laboratory workflows, and the ability to drive clarity, alignment, and execution across diverse stakeholder groups. Essential Functions: Provide project management expertise in implementation of financial systems, lab informatics systems (LIMS, ELN, LES, instrument data platforms), and related IT business applications. Develop and maintain comprehensive project documentation including project charter, project plan, communication plan, risk management documentation, etc. Collaborate with cross‑functional stakeholders across Finance, IT, Lab Operations, Quality, Supply Chain, and external vendors. Drive all project phases: requirements gathering, solution design, configuration, integration, testing, validation, deployment, and hypercare. Facilitate regular project meetings, decision logs, documentation, and communication of updates to leadership and sponsors. Identify risks, constraints, and dependencies early; drive mitigation planning and contingency strategies. Lead change management strategies including communication plans, training, and post‑go‑live support. Leverage new systems to streamline workflows across finance and laboratory operations. Standardize processes, data models, and reporting across functions to strengthen operational efficiency and data reliability. Requirements:&nbsp; Bachelor’s degree in business, information technology, or a related field. Master’s degree preferred. Other combinations of education and/or experience may be considered. Minimum 8 years of project management experience in IT system implementations, including work with finance systems and lab informatics systems. Experience in biotechnology, pharmaceuticals, medical devices, or other regulated scientific environments. Experience with change management frameworks. Familiarity with GxP validation practices and documentation. Proven success leading multiple projects in complex, multi‑stakeholder organizations. Experience working with scientific, finance, and IT teams simultaneously. Strong understanding of financial processes (budgeting, GL, AP/AR, procurement, reporting) and laboratory workflows (sample lifecycle, instrument data, QA/QC, data integrity). Advanced proficiency in Smartsheet, including; Complex project plan development, Automation workflows, Portfolio and executive‑level dashboards Demonstrated ability to build dashboards and reporting tools that summarize health, risks, KPIs, and resource status for leadership. High level of organization, analytical thinking, resourcefulness, and problem‑solving. Ability to thrive in dynamic, high‑growth environments with evolving priorities. Excellent verbal and written communication skills, with the ability to engage and influence stakeholders at all levels. Reports to:&nbsp;Senior Director, Business Process Excellence &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $166,000 - $195,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Project Manager

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an accomplished Associate Director, Immunoassay Development to join the Global Analytical Development organization. This role will provide scientific and strategic leadership for immunoassay development across Vaxcyte's vaccine pipeline, supporting platform evaluation and innovation, outsourcing and vendor oversight, method transfer, validation, lifecycle management, routine analytical testing, and immunoassay control strategy.This is an onsite, laboratory-based scientific leadership role with significant hands-on responsibilities and daily engagement in laboratory operations, experimental planning, assay execution, study oversight, data review, and technical support. The Associate Director will lead and directly contribute to assay design, assay execution, data analysis, troubleshooting, method optimization, platform evaluation, method transfer support, validation readiness, and routine non-GMP or GMP-supporting analytical testing for complex conjugated vaccine programs and other vaccine pipeline assets.The successful candidate will bring strong technical expertise in immunoassay development for vaccines or biologics, with demonstrated experience developing, optimizing, troubleshooting, and lifecycle-supporting potency-, antigenicity-, identity-, and impurity-related immunoassays in CMC or regulated analytical environments. A key responsibility of this role will be to strengthen Vaxcyte's hands-on immunoassay capability by developing new fit-for-purpose immunoassays, supporting platform evaluation and innovation, advancing assay robustness, and contributing to analytical control strategy across the vaccine pipeline. The Associate Director will work closely with internal and external immunoassay subject matter experts, Analytical Development, ASAT, QC, Process Development, Manufacturing, Quality, Clinical Serology, Regulatory, Program Management, CROs, CDMOs, contract testing laboratories, and technology partners to support method development, outsourcing, validation readiness, routine testing, GMP readiness, and long-term assay lifecycle strategy. Essential Functions: Contribute to the establishment and growth of the Immunoassay Development Capability within the Global Analytical Development organization, with emphasis on hands-on immunoassay development, troubleshooting, method optimization, platform evaluation, routine testing, outsourcing support, validation readiness, and control strategy execution. Engage daily in laboratory operations, including experimental planning, assay execution, sample and reagent readiness, study scheduling, instrument and workflow coordination, data review, documentation, and hands-on technical support. Lead and directly execute laboratory studies for immunoassay development, optimization, troubleshooting, qualification support, method transfer, validation support, lifecycle management, and routine analytical testing. Provide hands-on technical leadership for immunoassays supporting potency, antigenicity, identity, impurity, characterization, comparability, release, and stability needs for complex conjugated vaccines and other vaccine pipeline programs. Design, execute, and interpret experiments to evaluate assay format, sample preparation, reagent strategy, plate or bead configuration, signal detection, curve behavior, recovery, precision, specificity, robustness, and system suitability. Independently troubleshoot immunoassay performance trends using structured, data-driven root-cause analysis approaches and clear experimental plans. Support development of new fit-for-purpose immunoassay methods from concept through optimization, qualification readiness, transfer readiness, validation readiness, and lifecycle strategy. Assess alternative and innovative immunoassay approaches, platforms, and formats to support assay modernization, multiplexing, throughput, sensitivity, specificity, robustness, and long-term control strategy. Support comparative evaluation of immunoassay technologies, including ELISA, MSD, Luminex, and other relevant ligand-binding assay formats. Perform and oversee routine analytical testing within the CoE, including development-stage testing, characterization testing, platform evaluation studies, method bridging, comparability support, reagent qualification, and other non-GMP or GMP-supporting analytical activities. Support outsourced immunoassay activities with CROs, CDMOs, contract testing laboratories, reagent vendors, and external technology partners, including technical scope definition, study design review, data review, vendor communication, and deliverable tracking. Support immunoassay method validation activities in partnership with ASAT, QC, Quality, Regulatory, and external testing partners, including protocol input, acceptance criteria, data interpretation, deviation support, and final report review. Partner with internal and external subject matter experts to understand assay design, critical reagents, reference materials, method performance attributes, and control strategy needs. Support QC and ASAT teams in technical questions related to release, stability, comparability, PPQ, method transfer, validation readiness, and commercial readiness activities. Contribute to immunoassay analytical control strategies, including critical reagent strategy, reference material strategy, sample preparation, assay controls, system suitability, bridging plans, trending, and lifecycle monitoring. Manage assigned immunoassay development, troubleshooting, outsourcing, validation-support, platform evaluation, and routine testing activities, including study planning, resource coordination, timeline management, data review, deliverable tracking, and risk escalation. Mentor and provide technical guidance to laboratory scientists on experimental design, assay execution, data interpretation, troubleshooting, documentation, and good laboratory practices. Contribute to regulatory submissions, health authority responses, technical reports, method development reports, validation strategies, comparability packages, platform evaluation summaries, and BLA-supporting documentation. Represent Immunoassay Development in technical project meetings, cross-functional reviews, vendor discussions, and external collaborations as needed. &nbsp; Requirements:&nbsp; PhD. in Biochemistry, Immunology, Analytical Chemistry, Biological Sciences, or a related discipline with a minimum of 7 years of relevant biopharmaceutical industry experience; or M.S. in a related discipline with a minimum of 10 years of relevant biopharmaceutical industry experience. Other combinations of education and/or experience may be considered. Significant hands-on laboratory experience developing, optimizing, troubleshooting, transferring, validating, lifecycle-supporting, and executing immunoassays in vaccine CMC, biologics analytical development, QC, ASAT, or other regulated analytical environments. Demonstrated expertise in immunoassay method development, including assay format selection, antibody reagent strategy, reagent screening, reagent evaluation and selection, sample preparation, assay optimization, robustness assessment, qualification, validation readiness, and lifecycle management. Strong technical experience with ligand-binding immunoassay platforms such as ELISA, MSD, Luminex, or other relevant immunoassay technologies. Proven ability to troubleshoot complex immunoassay performance trends using structured, data-driven root-cause analysis approaches. Experience evaluating alternative or innovative immunoassay platforms and translating experimental data into method development recommendations. Experience developing or improving potency, antigenicity, identity, or impurity assays supporting vaccine or biologics release, stability, comparability, process development, method transfer, validation, routine testing, or regulatory submissions. Experience supporting outsourced immunoassay activities, including CRO, CDMO, contract testing laboratory, reagent vendor, or external technology partner interactions. Demonstrated ability to support daily laboratory operations, including study planning, sample and reagent readiness, testing prioritization, data review, documentation, and technical troubleshooting. Direct experience with conjugated vaccines, polysaccharide-protein conjugates, multivalent vaccines, or other complex biologics is strongly preferred. Solid understanding of protein chemistry, polysaccharide chemistry, conjugation chemistry, antigen structure, antibody-antigen interactions, and biological sample matrix effects as applied to vaccine analytical development. Hands-on experience with MSD platforms is highly desirable. Hands-on experience with Luminex or other multiplex immunoassay platforms is a plus. Experience working in or supporting GMP-regulated analytical environments is desired, including familiarity with method qualification, validation, transfer, change control, deviations, investigations, CAPA, data integrity, and lifecycle management. Working knowledge of global regulatory expectations for analytical methods supporting vaccines and biologics, including FDA, EMA, ICH, and GMP expectations. Demonstrated ability to mentor, train, and provide technical guidance to laboratory scientists. Strong ability to manage multiple laboratory studies, technical workstreams, outsourced activities, validation-support activities, routine testing needs, timelines, and deliverables in a fast-paced, matrixed environment. Strong scientific judgment and the ability to make sound technical recommendations when working with incomplete, complex, or conflicting data. Excellent written and verbal communication skills, with the ability to clearly communicate technical concepts, study results, risks, and recommendations to cross-functional stakeholders and external partners. Strong commitment to data integrity, documentation quality, scientific excellence, accountability, and continuous improvement. Preferred Qualifications: Experience supporting late-stage development, PPQ readiness, BLA preparation, commercial launch, or lifecycle management of vaccine or biologics programs. Direct experience supporting analytical methods used for GMP release and stability testing. Experience with immunoassay transfer, validation, bridging, comparability, critical reagent qualification, reference material qualification, and long-term method performance monitoring. Experience managing or supporting outsourced immunoassay development, validation, platform evaluation, or routine testing activities with external laboratories or technology partners. Experience developing alternative or next-generation immunoassay methods to strengthen analytical capability and support long-term control strategy. Experience contributing to health authority responses or regulatory submissions on analytical, potency, antigenicity, or immunoassay-related topics. Experience helping build or scale analytical capabilities, Centers of Excellence, or laboratory teams within a growing organization. Experience with multivalent or highly complex vaccine programs. Experience with automation, high-throughput immunoassay workflows, multiplex assay design, LIMS, ELN, and digital data analysis tools. Reports to: Senior Director, Global Analytical Lead – Commercial Readiness and Analytical Strategy &nbsp; Location: San Carlos, CA &nbsp; Work Arrangement: Onsite &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $190,000 - $220,000&nbsp; &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Immunoassay Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Scientist II, Conjugation Development who will contribute to the development of a robust process for generating Vaxcyte’s proprietary pneumococcal conjugate vaccine. The successful candidate will be proficient in basic laboratory techniques and be responsible for the support of the scientists in the execution of large and complex experimentation. Specifically, this will include synthesis, purification, and analytical characterization of polysaccharide-protein conjugates. With the training provided, the successful candidate will be expected to optimize and troubleshoot the synthesis and purification procedures independently with minimal guidance. The candidate will work in a fast-paced environment, must be a collaborative team player, has a strong desire to learn new techniques and concepts, and be committed to Vaxcyte mission. Essential Functions: Make buffers and other process solutions to support the Conjugation team during Process Characterization Analyze conjugates with several methods including colorimetric assays and multiple HPLC assays. Purify conjugates using a variety of methods including size-exclusion chromatography and tangential flow filtration (TFF). Contribute to the development and execution of Design of Experiment (DoE) models for process development. Support the development work toward a process characterization of conjugate vaccine. Design and execute basic process development experiments with minimal guidance Complete any assigned tasks in high quality and in a timely manner. Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports. Assist in troubleshooting of instrumentation and test methods, including the ordering of supplies and maintenance of equipment. Participate in group meetings, present results of work, interpret data, and report results in an accurate manner. Work within a team environment and provide support to further team objectives. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Experience in setting up and carrying out chemical reactions. Experience with protein conjugation reactions is a major plus. Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, size-exclusion chromatography, and tangential flow filtration (TFF). Hands on experience with analytical methods including reversed-phase HPLC, colorimetric assays, size-exclusion chromatography (SEC), and SDS-PAGE for characterization of reaction products. Direct experience operating Agilent HPLC using OpenLab/ Chemstation software and/ or Waters UPLC and Empower software for data acquisition and analysis is a plus. Highly organized, strong attention to details and excellent record keeping/documentation abilities. Critical thinking and ability to analyze data. Eager and able to learn and understand new concepts. Strong interpersonal skills and ability to communicate effectively with team members. Ability to work under supervision and collaborate effectively with team members. Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work. Reports to: Scientist II, Conjugation Development Location: San Carlos, CA&nbsp;Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.&nbsp;Salary Range: $105,000 – $122,000 *(SF Bay Area). Salary ranges for non-California locations may vary. We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly skilled Manager, Quality Systems to ensure adherence to regulatory standards, continuous improvement, and operational excellence within our organization. The ideal candidate will have experience in quality management systems (QMS), a background in regulatory requirements, and experience successfully validating, implementing and maintaining quality systems in a regulated industry. Essential Functions: Assist with development and maintenance of the company's Quality Management System (QMS) in accordance with company procedures and regulatory requirements (e.g.,.21CFR Part 11). Act as SME for the Vaxcyte QMS and assist users with technical system issues. Assist with driving continuous improvement initiatives that relate to QMS to enhance quality, efficiency, and compliance across all departments. Assist with GxP system implementation, validation, and maintenance activities from a QA perspective as required. Collaborate cross-functionally with IT, and other departments to ensure alignment on quality objectives and initiatives. Strive to foster a culture of quality and continuous improvement. Assist with preparation for and participate in regulatory inspections and customer audits, ensuring readiness and compliance. Ensure alignment with department management and company vision. Promote a quality mindset and quality excellence approach to all activities. Complete other responsibilities, as appropriate. Requirements:&nbsp; Bachelor's degree in a relevant scientific discipline. Minimum of 5 years of experience in quality management within a regulated industry (e.g., medical devices, pharmaceuticals, biotechnology). Other combinations of education and/or experience may be considered. Demonstrate knowledge of GXP regulations and guidelines as it pertains to Quality Systems. Experience in assisting with the validation, implementation, and managing Quality Management Systems (QMS) compliant with FDA regulations (e.g., 21 CFR Part 820), and other relevant regulatory requirements. Experience driving cross-functional collaboration. Excellent analytical and problem-solving abilities, with a keen attention to detail. Experience with Veeva QMS required. Knowledge or experience with Computer System Validation and/or Computer Software Assurance highly desirable. Experience with test script execution, a plus. Ability to work in a collaborative team environment. Reports to: Associate Director, Quality Systems &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $148,000 - $173,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Systems

<div class="content-intro"><h3><strong>Join our Mission to Protect Humankind!</strong></h3>
<div>Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp;</div>
<div>&nbsp;</div>
<div><strong>WHAT</strong>&nbsp;we do is every bit as important as&nbsp;<strong>HOW</strong>&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values:</div>
<div>&nbsp;</div>
<div>*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.</div>
<div>&nbsp;</div>
<div>*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.</div>
<div>&nbsp;</div>
<div>*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.</div>
<div>&nbsp;</div>
<div>*MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.</div></div><h3><strong>Summary:</strong></h3>
<p>Vaxcyte is looking for an energetic and talented individual to lead Vaxcyte’s Physical Security organization. The primary function of this Director-level position is to lead Physical Security operations for all Vaxcyte global sites, to include offices, laboratories, clinical/manufacturing sites, etc. This position will develop, manage and grow a high-performing and service-centric team comprised of full-time employees, contingent workers and 3<sup>rd</sup> party partners. Beyond functional and technical experience, primary keys to success for this role focus on relationships, culture, trust, forward thought, and operational excellence. We are looking for a curious and empathetic individual who is committed to growth and excellence. This position reports to the Senior Director Facilities.</p>
<h3>Essential Functions:</h3>
<ul>
<li>Develop and mature the physical security function at Vaxcyte, including access control and monitoring, executive protection, corporate physical security and ongoing monitoring of news and events which may impact Vaxcyte’s operations or employees.</li>
<li>Enhance the security program, ensure regulatory compliance, optimize access and strengthen the enterprise security posture by implementing best in class, risk appropriate, security technologies, policies and procedures.</li>
<li>Work collaborative with stakeholders, including Vaxcyte executives, to develop security processes and implement protection for corporate locations, industry and corporate events, and personal residences.</li>
<li>Develop and lead our Physical Security team in the identification, development and deployment of security technologies and processes.</li>
<li>Deploy comprehensive visibility technologies and alerting processes throughout Vaxcyte’s global sites.</li>
<li>Develop, communicate and implement executive protection for Vaxcyte’s leadership.</li>
<li>Partners across the organization to maintain regulatory compliance for physical security across multiple countries and regions. This includes SOC standards.</li>
<li>Track industry trends and emerging technologies to ensure the program remains innovative and effective.</li>
<li>Track current events and weather, measuring their impacts to Vaxcyte’s operations, sites and personnel.</li>
<li>Develop key results and performance metrics, communicating them on a regular basis to all level of Vaxcyte’s leadership.</li>
<li>Responsible for the development, implementation and oversight of Vaxcyte Physical Security training, processes, procedures and requirements.</li>
<li>Develop and manage a budget to support operational and capital requirements.</li>
<li>Complete assessments and audits to measure the efficiency of Vaxcyte’s compliance and security, access control and related systems.</li>
<li>Ability to understand and interpret laws and regulatory requirements related to information protection; develop and implement appropriate processes to achieve and maintain compliance and reduce risk.</li>
<li>Responsible for Vaxcyte’s Workplace Violence Prevention Plan (WVPP).</li>
<li>Occasional travel, including international, will be required.</li>
</ul>
<h3>Requirements:&nbsp;</h3>
<ul>
<li>BA/BS degree in a STEM, or other technical-related degree preferred and minimum 12 years’ physical security experience with at least 5 years of in-house security leadership and developing security programs. Other combinations of education and/or experience may be considered.</li>
<li>5+ years’ people-management experience.</li>
<li>Strong, proactive communication skills.</li>
<li>Expertise creating physical security site plans for corporate locations, manufacturing sites and personal residences.</li>
<li>Knowledge of contemporary security technologies.</li>
<li>Experience working local, state and federal law enforcement.</li>
<li>Experience liaison with foreign law enforcement</li>
<li>Ability to provide risk-based guidance for corporate travel and events.</li>
<li>Experience building and leading high-performance teams.</li>
<li>Experience developing and complying with policies, standards and processes.</li>
<li>Experience managing a global team in multiple time zones.</li>
<li>Ability to influence and motivate cross functional teams.</li>
<li>Ability to develop multi-year plans, objectives and key results, key performance indicators and communicate all of the above to stakeholders at multiple levels.</li>
<li>Ability to interact with company executives in a clear and concise manner, providing guidance and expertise in high-stress situations.</li>
<li>Develop risk appropriate Emergency Operation and Action Plans (EOP and EAP).</li>
<li>Assess the need for the development and establishment of a global security operations center (GSOC).&nbsp; Lead and manage a team of security analysts and operators to the operation of a GSOC.</li>
<li>Provide guidance, mentorship, and support to team members, fostering a culture of excellence, collaboration and continuous improvement.</li>
<li>Oversee 24x7 monitoring of security systems, including CCTV, access control, intrusion detection and threat intelligence feeds.</li>
<li>Certified Information Systems Security Professional (CISSP) or International Association of Privacy Professionals (IAPP) certifications and or/advanced degree will be considered a plus.</li>
</ul>
<div><strong>Reports to:&nbsp;</strong>Senior Director, Facilities</div>
<div>&nbsp;</div>
<div><strong>Location:&nbsp;</strong>San Carlos, CA</div>
<div>&nbsp;</div>
<div><strong>Work Arrangement: </strong>Onsite (minimum of 4 days per week) and 24x7 on-call support is required.</div>
<div>&nbsp;</div>
<div><strong>Compensation:</strong></div>
<div>The compensation package will be competitive and includes comprehensive benefits and an equity component.</div>
<div>&nbsp;</div>
<div><strong>Salary Range: </strong>$215,000 - $251,000 (SF Bay Area). Salary ranges for non-California locations may vary.</div>
<div>&nbsp;</div>
<div><strong>Relocation:&nbsp;</strong></div>
<div>This role is eligible for relocation assistance.&nbsp;</div><div class="content-conclusion"><p><em>We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.</em></p>
<p>&nbsp;</p></div>

Director, Physical Security

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Engineer II, Conjugation Development who will contribute to the development of a robust process for generating Vaxcyte’s proprietary pneumococcal conjugate vaccine. The successful candidate will be proficient in basic laboratory techniques and be responsible for the support of the team in the execution of large and complex experimentation. The candidate will work in a fast-paced environment, must be a collaborative team player, has a strong desire to learn new techniques and concepts, and be committed to Vaxcyte mission. Essential Functions: Prepare samples for analysis, execute analytical procedures according to the SOP, and perform data analysis. Provide assay supports to Conjugation Development team. Contribute to CMO Manufacturing oversight via document review. Present/communicate data to the Conjugation Development team. Operate, maintain, and troubleshoot HPLC instruments. Analyse data using appropriate software tools. Interpret, communicate, and present data. Assist with authoring and maintaining standard operating procedures. Document results of analyses and experiments with an electronic notebook system. Requirements:&nbsp; BS degree in Chemical Engineering, Biological Engineering, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Prior hands-on experience in a laboratory setting. Hands on experience with analytical methods including Colorimetric Assays, HPLC-SEC, SEC-MALS, and SDS-PAGE is desired. Experience with purification methods such as Dialysis, HPLC, or Tangential Flow Filtration (TFF) is a plus. Highly organized, strong attention to details and excellent record keeping/documentation abilities. Critical thinking and ability to analyse data. Eager and able to learn and understand new concepts with ease. Strong interpersonal skills and ability to communicate effectively with team members. Ability to work under supervision and collaborate effectively with team members. Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work Reports to: Staff Engineer, Conjugation Development Location: San Carlos, CA&nbsp;Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.&nbsp;Salary Range: $105,000 – $122,000 *(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Engineer II, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Scientist II, Conjugation Development, who will contribute to the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on the synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The successful candidate will apply a strong foundation in analytical chemistry and laboratory techniques to optimize and troubleshoot processes, while also supporting related areas such as analytical development and stability studies. This position requires strong organizational skills, clear communication, and the ability to work in a fast-paced, cross-functional environment. Essential Functions: Perform and optimize multi-step syntheses of protein-polysaccharide conjugates. Purify polysaccharides and conjugates using methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF). Analyze polysaccharides and conjugates using methods such as colorimetric assays, HPLC assays, SEC-MALS, and SDS-PAGE, and contribute to method bridging studies and qualification to ensure robustness and consistency. Maintain accurate, well-organized experimental records and support data verification and analysis to enable process optimization and reproducibility. Assist with troubleshooting of synthesis, purification, and analytical procedures. Track inventory of critical reagents and assist with ordering as needed. Support maintenance of assigned lab instruments, perform general lab duties, and contribute to training new team members. Present experimental results and progress updates at group meetings. Contribute to laboratory protocols, reports, and other documentation supporting process development. Collaborate effectively with team members and contribute to cross-functional activities. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, and size-exclusion chromatography; experience with TFF is desirable. Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE. Hands-on experience with protein conjugation reactions or chemical modification of polysaccharides is desirable. Strong attention to detail, organizational skills, and record-keeping abilities. Effective communication skills, both verbal and written. Ability to work both independently and collaboratively in a fast-paced environment. Enthusiasm for learning new skills and applying them to challenges outside of current expertise. Commitment to integrity, professionalism, and safety in all aspects of work. Reports to: Senior Scientist, Conjugation Development Location: San Carlos, CA&nbsp;Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.&nbsp;Salary Range: $105,000 – $122,000 *(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our analytical development team. Primary responsibility for the incumbent will include method development, sample testing and data analysis, protocol and report authorization, and analytical method transfer oversight and coordination. Essential Functions: Independently perform method development for a wide range of analytical techniques used in raw material testing for both quality control and characterization, supporting pre-clinical and clinical projects. Support method transfer to external contract testing labs; design and perform studies to assist troubleshooting of QC testing, method qualification/validation or issues related to the methods as needed. Perform analytical testing, data analysis and interpretation and present in various project and functional team meetings. Collaborate with cross-functional teams to achieve project timelines and goals. Maintain thorough and accurate records of laboratory work. Author analytical documents including but not limited to test method, protocols, and reports. Requirements:&nbsp; PhD in Analytical Chemistry, Biochemistry or a related field with 2-5 years of industry experience; MS with 7+ years of industry experience; BS with 10+ years of industry experience in Pharma/Biotech. Other combinations of education and/or experience may be considered. Extensive hands-on experience in a wide range of analytical techniques, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, LC-MS, GC-MS, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, PCR, etc. Adeptness in learning: given the broad range of molecular structures and analytical methods involved, the ability to quickly learn and adapt to new techniques and technologies is paramount. Ability to analyze complex problems, identify potential solutions, and make informed decisions is critical for the success of this role. Familiar with regulatory standards and quality systems (e.g., GLP, GMP) Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Effective communication and interpersonal skills, with the ability to collaborate cross-functionally and work effectively in a team environment. This position is a lab-based role and requires onsite presence. Reports to: Associate Director, Analytical Development, Raw Materials &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $146,000 – $171,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist II, Analytical Development for Raw Materials

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an accomplished Director, Immunoassay Development to establish and lead a dedicated analytical function focused on immunoassay development for complex conjugated vaccines. This role will build and manage a laboratory-based team responsible for developing, sustaining, and continuously improving potency- and antigenicity-based immunoassays to support CMC development from preclinical through BLA-stage programs and commercialization. A key initial focus of this role will be stewardship of the VAX-31 MSD immunoassay platform, which has been developed and advanced to Phase 3 through extensive internal leadership spanning clinical serology, GLP studies, and immunoassay development. The successful candidate will work in close partnership with current immunoassay leadership to ensure comprehensive knowledge transfer, continuity of scientific and execution excellence, and the long-term robustness of the immunoassay strategy as accountability and responsibility intentionally transition into Analytical Development. This is a hands-on scientific leadership role anchored in CMC execution, GMP readiness, and lifecycle management of immunoassays supporting vaccine development, lot release and stability testing and commercialization. Essential Functions: Establish and lead a new Immunoassay Development function within Analytical Development, defining scope, strategy, and operating model aligned with CMC and program needs. For VAX-31, partner closely with current immunoassay leadership to learn and internalize the full development history, scientific rationale, and performance characteristics of the existing MSD-based immunoassay platform. Serve as scientific steward for the VAX-31 immunoassay, providing troubleshooting, root-cause analysis, and technical problem-solving support to Quality Control (QC) and Analytical Sciences and Technology (ASAT) teams. Support ASAT activities for VAX-31, including qualification, lifecycle management, and change control of critical immunoassay reagents. Develop and execute immunoassay strategies to support potency, antigenicity, identity, and trace-level impurity testing for conjugated vaccines across the pipeline. Lead the development and optimization of antigenicity- and potency-based immunoassays suitable for late-stage development and commercial use. Drive continuous improvement of existing immunoassays to enhance robustness, QC-friendliness, throughput, and long-term performance, even when methods are already deemed adequate. Build, mentor, and manage a team of laboratory scientists, fostering a cohesive, innovative, nimble, and high-performing team culture grounded in scientific rigor and accountability. Provide critical scientific judgment and problem-solving leadership when addressing complex, ambiguous, or conflicting technical challenges across programs. Manage immunoassay development activities across multiple projects, prioritizing resources, timelines, and deliverables in a fast-paced, matrixed environment; proactively escalate risks and issues to line management and project team as appropriate. Partner cross-functionally with Process Development, Manufacturing, Quality, Clinical Serology, and Regulatory teams to ensure alignment with overall CMC strategy and program timelines. Ensure immunoassay methods meet FDA, EMA, and ICH expectations for vaccines and biologics. Support regulatory submissions and health authority interactions through technical input, data review, and authorship of CMC documentation. Champion data integrity, scientific excellence, and continuous learning within the immunoassay organization. Requirements:&nbsp; Ph.D. in Biochemistry, Immunology, Analytical Chemistry, Biological Sciences, or a related field (or equivalent experience) with a minimum of 10 years of experience. Other combinations of education and/or experience may be considered. Significant hands-on experience developing immunoassays within vaccine CMC, analytical development, or other regulated laboratory environments. Expert-level, hands-on experience with MSD (Meso Scale Discovery) or closely related immunoassay platforms, including method development, optimization, troubleshooting, and lifecycle support. Direct experience with conjugated vaccines, including polysaccharide–protein conjugates. Solid understanding of protein chemistry and conjugation chemistry, particularly as applied to biological drug and vaccine development. Demonstrated expertise in potency and antigenicity assays supporting vaccine release, stability, and comparability. Strong working knowledge of GMP and global regulatory expectations (FDA, EMA, ICH) for analytical methods supporting vaccines. Demonstrated ability to think critically and exercise sound scientific judgment when navigating complex, ambiguous, or conflicting technical and organizational challenges. Proven track record of scientific problem-solving, including data-driven decision-making and root-cause analysis. Strong written and verbal communication skills, with the ability to clearly and efficiently communicate technical concepts across interdisciplinary and cross-functional teams. Ability to operate effectively in a fast-paced, matrixed environment, manage multiple priorities, and meet aggressive timelines. Project and resource management experience, including planning and coordination of materials, staffing, timelines, and deliverables, with the ability to appropriately escalate issues and risks. Preferred Qualifications: Experience supporting late-stage development and/or commercial vaccine programs. Direct interaction with global health authorities on analytical, potency, or immunoassay-related topics. Experience building or scaling analytical capabilities within a growing organization. Background in multivalent or highly complex vaccine programs. Reports to: Vice President, Analytical Development &nbsp; Location: San Carlos, CA (Onsite, laboratory-based leadership role) &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $213,000 – $250,000 *(SF Bay Area). Salary ranges for non-California locations may vary.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Immunoassay Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests. &nbsp; As a CMC IT Intern for Vaxcyte, you will work on a project as outlined below:&nbsp; Map manufacturing data from source documents into standardized structures within Vaxcyte’s internal data platform. Extract and organize data from spreadsheets and batch records to map tests, units, and procedures, and update the proprietary platform. Verify configurations to ensure data matches source records.&nbsp; The Intern will learn and practice:&nbsp;&nbsp; How data impacts vaccine development and manufacturing workflows within the biotech industry Common data management challenges, including data consistency, standardization, and downstream usability. Foundational skills in structure problem solving and collaboration with cross-functional teams.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.&nbsp;&nbsp; Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) or Graduate Degree with a focus on Computer Science, Data Science, or related field.&nbsp; Proficiency in Microsoft Office. &nbsp; Strong attention to detail and work quality. Demonstrates collaboration and teamwork.&nbsp; &nbsp; Enthusiastic-Shows curiosity and is eager to learn. Dedicated.&nbsp; Reports to:&nbsp;Senior Systems Analyst &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, CMC Information Technology, VAXDATA

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests. &nbsp; As a Conjugation Development Intern for Vaxcyte, you will work on a project as outlined below:&nbsp; Assist with experimental studies to understand how process inputs influence conjugation workflows and downstream processing. Generate and organize analytical data for predefined quality attributes and contribute to summary slides or short write-ups of results and learnings. Provide general lab and project support to the team by preparing materials, maintaining documentation, and helping execute planned experiments on schedule. The Intern will learn and practice:&nbsp;&nbsp; Conjugation techniques that enable protein-polysaccharide vaccine development. Application of Design of Experiments in a CMC/process development setting. How to interpret analytical results and use data-driven decision making to evaluate process impacts. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.&nbsp;&nbsp; Requirements:&nbsp; Currently pursuing a BS or MS degree in Bioengineering, Chemical Engineering, Chemistry, Biochemistry, or a related discipline; enrolled student with at least 2 years of university coursework completed. Prior wet-lab experience strongly preferred, including accurate pipetting, solution preparation, and basic documentation practices. Enthusiastic and curious to learn about bioconjugate development. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Reports to:&nbsp;Scientist I, Conjugation Development &nbsp; Location: San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As an Immunoassay Intern for Vaxcyte, you will work on a project as outlined below: Optimize the current assay platform to improve sensitivity and accuracy for detecting pneumococcal antigens in human samples. Conduct experiments to test the assay's ability to detect antigens in human samples spiked with known concentrations. Analyze and interpret results to refine assay protocols and troubleshoot issues that arise during testing.&nbsp; The Intern will learn and practice: Hands-on experience in optimizing immunoassays, which are widely applicable to various immunoassays used in clinical and manufacturing settings. Design experiments to test assay performance, analyze results, and troubleshoot issues.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Biology, Biochemistry, or related field.&nbsp; Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to: Senior Manager, Nonclinical &amp; Immunoassay &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Immunoassay

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Legal Intern for Vaxcyte, you will work on a project as outlined below: Review and better leverage existing Legal/enterprise tools; enhance the weekly Legal Dashboard and contribute to a broader Legal Team Dashboard, including automation, usability, and AI features. Support PowerPoint slide automation and content generation, and assist with Ironclad API development and integrations. Evaluate AI tools for recording, summarizing, and documenting Legal trainings, and explore best practices for using Microsoft Copilot across email and documents. Develop an internal AI-focused newsletter with tips, best practices, and resources. Research and recommend relevant AI conferences, panels, and external programming for Legal teams. The Intern will learn and practice: Gain hands-on experience owning and executing AI initiatives within an in-house legal team. Develop practical skills in AI implementation, tool evaluation, automation, and technical-to-business communication, while learning how legal teams responsibly pilot and adopt AI solutions in a regulated corporate environment. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) or a Master’s Degree with a focus on Computer Science, Data Science, Artificial Intelligence, Machine Learning, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to:&nbsp;Senior Vice President, General Counsel, Chief Compliance Officer and Corporate Secretary &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Legal Technology & AI

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Polysaccharide Intern for Vaxcyte, you will work on a project as outlined below: Conduct a literature review to evaluate potential methods (chemical treatment) for removing residual impurities from intermediate fill materials. Design and execute laboratory studies to assess the effectiveness of the selected purification approach across multiple PCV serotypes. Perform chemical treatments and measure polysaccharide recovery using relevant analytical assays. Document experimental conditions and results, analyze data, and evaluate potential impacts on critical quality attributes (CQAs). Present findings and recommendations to support ongoing PCV process development efforts. The Intern will learn and practice: Applying scientific literature to inform experimental design and guide purification process development strategies. Evaluating purification concepts to determine feasibility and relevance for real-world manufacturing applications. Assessing method performance through structured feasibility studies and comparative analysis. Developing data-driven decision-making skills to support process optimization and technical recommendations. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 2 years at university completed) or Master’s Degree with a focus on Bioengineering, Chemical Engineering, Chemistry, or Biochemistry. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Nice to Have – previous lab experience (wearing PPE, handling reagents, buffer making, pipetting) and equipment experience (AKTA) Reports to:&nbsp;Engineer I, Polysaccharide &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Polysaccharide

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Protein Intern for Vaxcyte, you will work on a project as outlined below: Perform a literature review to understand cell-free protein synthesis (CFPS) and key principles of small-scale bioreactor operation. Support the design and execution of development studies aimed at establishing operating conditions in the Ambr 15 microbioreactor system for maintaining CFPS reaction setpoints (e.g., temperature, dissolved oxygen, and pH). Analyze experimental data to help design next studies or finalize operating conditions for 10 mL CFPS reactions. Document findings by drafting a work practice/SOP for running CFPS reactions in the Ambr 15 system. Present results and recommendations to the Protein team to support ongoing process development efforts. The Intern will learn and practice: Bioreactor operations and scale-down principles. Data analysis (process trends and analytical results). Electronic lab notebook (ELN) record keeping. Science communication. SOP/work practice writing skills.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Biochemical Engineering, Chemical Engineering, Bioengineering, or Biochemistry. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to:&nbsp;Scientist I, Protein &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Protein

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Research Intern for Vaxcyte, you will work on a project as outlined below: Focus on protein expression and purification to support development of alternate protein carriers. Contribute to technical and analytical efforts to finalize processes. Screen protein constructs and purification strategies using small-scale expression and purification experiments. Generate and analyze data to identify promising constructs and optimize purification workflows. The Intern will learn and practice: Different AKTA FPLC chromatography methods, such as IMAC, SEC, and AEX, while obtaining meaningful exposure to industry relevant workflows. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Master’s Degree with a focus on Microbiology, Molecular Biology, Biochemistry, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to:&nbsp;Scientist I, Research &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Research Intern for Vaxcyte, you will work on a project as outlined below: Support formulation and stability activities for a pipeline molecule within Research, gaining hands-on laboratory experience. Assist in executing a stability study, including sample preparation, storage, and testing. Collect, organize, and analyze stability data to evaluate storage and handling conditions. Assess the impact of excipients on molecule stability and overall formulation performance. Present findings and recommendations to the Research team. The Intern will learn and practice: The day-to-day responsibilities of a bench scientist within a pharmaceutical research environment. Fundamental principles of vaccine development, including how Vaxcyte’s programs contribute to global public health. Designing and executing high-quality experiments using the scientific method in an industry setting. Collecting, analyzing, and interpreting experimental data to support research decisions. Operating and gaining hands-on experience with modern laboratory instrumentation and analytical tools. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Chemistry, Biology, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to:&nbsp;Senior Associate Scientist, Research &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a CMC IT Intern for Vaxcyte, you will work on a project as outlined below: Support development and customization of an nf-core pipeline for protein structure prediction. Assist with deployment and optimization of the pipeline in Azure within an existing VNet. Develop or enhancing a basic user interface to allow scientists to submit jobs and review results. Act as a liaison between scientists and IT to gather requirements and translate them into technical solutions. The Intern will learn and practice: How protein folding prediction tools and prediction tools are operationalized in an enterprise setting. Deploy and secure scientific applications in Azure within a virtual network. Skills in performance optimization, cost analysis, and cloud resource tuning. Collaboration with scientists and IT professionals to translate research needs into scalable technical solutions. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Computer Science, Bioinformatics, Computational Biology, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to: Principal Data Systems Engineer &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, CMC Information Technology

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests. &nbsp; As a Conjugation Intern for Vaxcyte, you will work on a project as outlined below:&nbsp; Develop a new method for quantifying polysaccharide molecular weight using chromatography techniques. Further develop existing methods to leverage them for reading samples with higher levels of process impurities. Design and execute experiments in support of the broader conjugation team goals.&nbsp; The Intern will learn and practice:&nbsp;&nbsp; How the conjugation process fits into the broader vaccine development process. Preparing reagents, buffers, and mobile phases for various assays/instruments. Performing colorimetric assays to assess concentration and impurity levels. How to set up and run samples on HPLC/SEC-MALS, and then analyze the generated results. &nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.&nbsp;&nbsp; Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Chemistry, Biology, Biochemistry, or related field.&nbsp; Proficiency in Microsoft Office. &nbsp; Strong attention to detail and work quality. Demonstrates collaboration and teamwork.&nbsp; &nbsp; Enthusiastic-Shows curiosity and is eager to learn. Dedicated.&nbsp; Reports to:&nbsp;Senior Associate Scientist, Conjugation &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range:&nbsp;The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests. &nbsp; As a Facilities Intern for Vaxcyte, you will work on a project as outlined below:&nbsp; Participation in and documentation of active construction and lab/gas equipment installation projects. Creation or update of asset records within the Facilities Asset Management system. Review and documentation of preventative maintenance schedules and PM completion rates. Accurate entry, tracking, and reporting of work orders in the CMMS. Completion of space planning exercises, including space data updates and utilization analysis using space planning systems. Timely and accurate triage, tracking, and reporting of workplace and security tickets.&nbsp; The Intern will learn and practice:&nbsp;&nbsp; Learn how facilities, lab, and construction projects move from planning through execution and closeout. Hands-on exposure to asset management, preventative maintenance concepts, and how reliability, safety, and compliance are maintained in an operational environment. Build familiarity with tools such as CMMS, space planning systems, and ticketing systems to track work, assets, and space metrics. &nbsp; Gain an understanding of how Facilities partners with vendors, contractors, and other internal teams to deliver projects and day-to-day support.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.&nbsp;&nbsp; Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Construction Management, Facility Management, Business Management, or related major Proficiency in Microsoft Office. &nbsp; Strong attention to detail and work quality. Demonstrates collaboration and teamwork.&nbsp; &nbsp; Enthusiastic-Shows curiosity and is eager to learn.&nbsp; Dedicated.&nbsp; Reports to:&nbsp;Director, Facilities &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range:&nbsp;The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Facilities

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Polysaccharide Intern for Vaxcyte, you will work on a project as outlined below: Receive training in microbiological techniques and analytical assays to support fermentation studies for multiple S.&nbsp;pneumoniae serotypes. Learn to operate the AMBR system to monitor and collect real-time fermentation data. Analyze and correlate optical density (OD) measurements across multiple systems to support implementation of an online biomass monitoring approach. Apply proper microbiological handling, data collection, and documentation practices to generate high-quality analytical results. Evaluate and validate the online biomass monitoring system across multiple serotypes to assess consistency and performance. The Intern will learn and practice: Sterile Microbiological Techniques. Streptococcus pneumonia upstream processes. Polysaccharide Analytical Assays. Data Documentation and Reporting. Independent Research and Problem Solving. Collaboration and Professional Development. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) or Master’s Degree with a focus on Biotechnology, Biochemistry, or Microbiology. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. This position is for the upstream polysaccharide lab (BSL2) and vaccination against S. pneumoniae is available and recommended.&nbsp; Reports to: Senior Associate Scientist, Polysaccharide Process Development &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Project Management Intern for Vaxcyte, you will work on a project as outlined below: Support the New Team Member Onboarding process to ensure that new team members are setup to efficiently onboard into CMC Project Teams. Triage team member intake submissions and coordinating project alignment meetings. Ensure closeout of transition plans and identify opportunities for improvement in the current process. Assist with the development and delivery of New Team Member Onboarding training content. The Intern will learn and practice: Onboarding and transitioning responsibilities of individual team members within the governance structure. Managing rollout and alignment of transitions across active project teams. Educating team members on governance culture, responsibilities, and expectations. Use of project management tools and systems to track and implement the activities listed above. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Business Administration, Biology, Chemistry, or related major. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to:&nbsp;Senior Project Manager, CMC &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students.&nbsp; Actual pay will be determined based on year of university/college completed.&nbsp; The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Project Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Quality Intern for Vaxcyte, you will work on a project as outlined below: Review drug substance manufacturing batch records to identify documentation issues that impact QA review timelines. Analyze QA review data and help develop tools to improve right-first-time execution and first-pass approval rates. Support documentation quality and data integrity efforts in partnership with QA and Manufacturing teams. Evaluate and organize documents in Veeva QualityDocs, and improve metadata accuracy. Present findings and recommendations to improve QA efficiency, compliance, and document management processes. The Intern will learn and practice: Defining and establishing baseline metrics for execution and QA batch record review processes. Analyzing performance metrics and identifying opportunities for measurable improvement. Designing manufacturing-focused QA tools suitable for pilot implementation. Evaluating data and formulating evidence-based recommendations for ongoing QA metric tracking. Reviewing and navigating CMC documentation within Veeva QualityDocs through hands-on application. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Biological Sciences, Engineering, or a related life science field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Demonstrates curiosity, enthusiasm, and a strong willingness to learn. Reliable, responsible, and dedicated to meeting commitments. Reports to:&nbsp;Sr. Quality Assurance Specialist, External Manufacturing &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Quality Assurance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Stability Intern for Vaxcyte, you will work on a project as outlined below: Assist with the migration of data to a new Stability Management Software in support of a company-wide initiative. Support the broader stability program through understanding of the vaccine development process, the application of statistical modelling, and the manufacturing pipeline. The Intern will learn and practice: Working within a validated software environment. The quality control parameters of stability data along with the importance of data integrity. A general understanding of the structure, outline, and purpose of stability studies. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Biology, Biochemistry, Biostatistics, Statistics, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to:&nbsp;Associate Scientist II, Stability &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Stability

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Quality Control Operations function is an executive role within a matrixed global vaccine organization, responsible for the implementation of Vaxcyte analytical strategies at our CDMO’s and CRO’s. This role is the single point of contact for our CDMO’s and CRO’s to ensure they deliver the quality, accuracy, and compliance of testing and analytical services. &nbsp;Working closely with the analytical technical lead and other functions within Analytics, Process Development, Analytical and Manufacturing Science and Technology, Quality Assurance, Manufacturing, and Regulatory Affairs, this role provides leadership and oversight for implementation of analytical strategies at the CDMO / external lab supporting analytical readiness and deliverables. The role is accountable that testing and release at our CDMO &amp; CRO is performed in a timely and compliant manner to ensure secure and uninterrupted supply of Vaxcyte’s innovative therapies. Essential Functions: Implement and maintain analytical strategies for process-related, release and stability testing for our programs at our CDMO/contract labs and ensure they are aligned with the CDMO's goals and objectives as well as comply with relevant regulations and industry standards. Implement, and maintain robust quality control systems that encompass sampling, testing, documentation, and release procedures. Ensure on-time performance for QC testing at our CDMO’s or contract laboratories related to raw materials, intermediates, and drug substance. Ensure that contracted QC laboratories are equipped with appropriate instrumentation and equipment, maintained according to regulatory requirements, and calibrated regularly to ensure accuracy and reliability of test results. In partnership with analytical technical lead and analytical science and technology as well as the contract laboratories, oversee method validation and transfer activities between contract laboratories. Assure that appropriate systems for data management, including secure storage, retrieval, and retention of QC data and documentation are in place. Ensure that all testing activities are well-documented and comply with Good Documentation Practices (GDP). Review and approval of analytical data, test reports, and certificates of analysis (CoAs) generated by contract laboratories to verify accuracy, completeness, and compliance with specifications for both release and stability testing. Lead and support investigations and deviations, out-of-specification (OOS), out-of-trend (OOT), out-of-expectation (OOE) results, laboratory incidents, and customer complaints related to contract laboratory testing, collaborating with contract laboratories and internal stakeholders to implement corrective and preventive actions (CAPAs). Provide technical support for product related regulatory documents and inspections by Health Authorities. Writing, review and approval of documents related to Quality Control to ensure compliance with applicable regulatory and industry standards. Requirements:&nbsp; Bachelor of Science with 10+ years of relevant experience in the biotechnology/pharmaceutical industry specifically in Quality Control. Other combinations of education and/or experience may be considered. Experience in Pneumococcal vaccines is a plus. Excellent experience in managing CDMOs and/or contract laboratories. Comprehensive knowledge in cGMP and experience in multi-national regulations. Excellent communication, negotiation, and relationship-building skills, with the ability to collaborate effectively with internal and external stakeholders. Strong analytical and problem-solving abilities, with a focus on data-driven decision-making and continuous improvement. Strong teamwork and interpersonal skills. Relentless focus and passion around process improvements (efficiency and automation). Experience with digital tools for data management, document review workflows. Level of Supervision: General Supervision The role will perform a variety of routine work within established policies and procedures. It is expected that the role receives rather high-level project information instead of detailed instructions on a weekly basis and general instructions on new projects and assignments. Reports to: Director, Quality Control &nbsp; Location: San Carlos, California or Raleigh/Durham/RTP area, North Carolina &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $184,000 - $214,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Quality Control Operations, Global Analytics

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Associate Director, SEC Reporting &amp; Technical Accounting will serve as a key contributor to the company’s external reporting and technical accounting function. Reporting to the Senior Director, Technical Accounting &amp; SEC Reporting, this role will be highly hands-on, owning the preparation and execution of SEC filings and technical accounting analyses while also managing one direct report.&nbsp; This role is ideal for a technically strong accounting professional who enjoys&nbsp;operating&nbsp;in the details, partnering cross-functionally, and helping build processes in a growing public biotechnology company.&nbsp; Essential Functions: SEC Reporting (Hands-On Execution)&nbsp; Own the preparation of quarterly and annual SEC filings, including Forms 10-Q, 10-K, and 8-K&nbsp; Prepare&nbsp;and/or review&nbsp;primary financial statements, footnotes, and related disclosures&nbsp;in accordance with&nbsp;U.S. GAAP and SEC requirements&nbsp; Draft and support MD&amp;A disclosures, with emphasis on R&amp;D, G&amp;A, stock-based compensation, and other pre-revenue biotech-specific areas&nbsp; Coordinate the quarterly close-to-reporting process across Accounting, FP&amp;A, Legal, and external auditors&nbsp; Support earnings release tie-outs and disclosure controls&nbsp; Technical Accounting&nbsp; Support technical accounting assessments and documentation for complex transactions, including:&nbsp; Collaboration, licensing, and R&amp;D-related arrangements&nbsp; Equity and equity-linked financing transactions&nbsp; Other complex&nbsp;and other non-routine transactions&nbsp; Research new accounting standards and SEC guidance; assess applicability and implementation impact&nbsp; Draft clear, well-supported technical accounting memos and communicate conclusions to stakeholders&nbsp; People Management&nbsp; Manage and mentor one direct report, providing coaching, review, and development support&nbsp; Review work products to ensure accuracy, quality, and adherence to timelines&nbsp; Foster strong execution discipline and continuous improvement within the reporting function&nbsp; Process Improvement &amp; Scaling&nbsp; Help design and enhance scalable SEC reporting and technical accounting processes as the company grows&nbsp; Partner with cross-functional teams to ensure accounting and reporting considerations are incorporated into business decisions&nbsp; Support SOX and internal control documentation&nbsp;related to SEC reporting and technical accounting&nbsp;as applicable&nbsp; Requirements:&nbsp; Bachelor’s degree in Accounting&nbsp;or related field; CPA&nbsp;strongly&nbsp;preferred with a minimum 10 years of progressive accounting experience, including:&nbsp;Public accounting experience (Big 4 or national firm strongly preferred)&nbsp;and/or direct SEC reporting experience at a public company.&nbsp; Other combinations of education and/or experience may be considered. Strong technical knowledge of U.S. GAAP and SEC reporting requirements Excellent written and verbal communication skills Highly detail-oriented with strong execution skills Comfortable operating in a fast-paced, evolving environment Strong ownership mindset with the ability to balance deadlines and quality Collaborative, proactive, and solutions-oriented&nbsp; Ability to work onsite 3 days per week required; and more often based on business needs.&nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $184,000 - $215,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, SEC Reporting & Technical Accounting

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team. The Associate Scientist II, Analytical Development, is responsible for executing analytical testing and supporting method development activities for biologics/vaccine development programs. This role will perform routine and non-routine analytical assays using modern analytical techniques and will contribute to method optimization, troubleshooting, and continuous improvement initiatives under supervision. The position requires demonstrated hands-on laboratory experience, strong technical execution, and the ability to work independently on routine tasks while supporting more complex development activities. Essential Functions: Analytical Testing &amp; Data Generation Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques). Prepare samples, reagents, standards, and buffers according to established protocols. Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable). Perform data processing and preliminary interpretation; summarize findings for review by senior scientists. Maintain accurate and timely documentation in laboratory notebooks or electronic systems. Method Development &amp; Troubleshooting (Under Supervision) Support method development, optimization, and qualification activities under the guidance of senior scientists. Assist in designing experiments to evaluate method parameters and robustness. Troubleshoot assay performance issues and instrument-related problems, proposing potential solutions for review. Participate in method transfer activities, including protocol execution and documentation. Contribute to drafting and revising analytical methods, SOPs, protocols, and technical reports. Laboratory Operations &amp; Instrumentation Coordinate instrument service activities and assist with vendor interactions as needed. Ensure laboratory organization, cleanliness, and proper material storage. Manage inventory of reagents, standards, and consumables; assist with procurement and restocking. Safety &amp; Compliance Follow all Environmental Health &amp; Safety (EHS) policies and laboratory safety practices. Handle chemicals and biological materials safely and in compliance with regulatory requirements. Ensure proper waste disposal and adherence to hazardous material handling procedures. Support audit and inspection readiness activities where applicable. Team Collaboration Collaborate with cross-functional teams to support project timelines and deliverables. Provide clear communication on experimental progress, risks, and results. Contribute to a positive, compliant, and scientifically rigorous laboratory culture. May assist in training junior staff or new team members on routine assays and lab practices Requirements:&nbsp; Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline with 2-4 relevant laboratory experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered. Hands-on experience with analytical techniques such as chromatography, electrophoresis, or immunoassays is required. Experience supporting method development or optimization activities preferred. Solid understanding of analytical chemistry or biochemistry principles. Experience with method troubleshooting and data interpretation. Familiarity with analytical software and data analysis tools. Strong attention to detail and organizational skills. Ability to work independently on routine assignments and manage multiple tasks. Effective written and verbal communication skills. Ability to work in a laboratory environment for extended periods. Ability to lift up to 30 lbs. Use of personal protective equipment (PPE) required. Contribute to a positive, inclusive, and safety-focused laboratory culture Reports to: Associate Director, Analytical Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $105,300 - $122,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team. The Associate Scientist I, Analytical Development, will support analytical testing activities for biologics/vaccine development programs. This role is responsible for executing routine and non-routine analytical assays using modern analytical techniques, maintaining laboratory equipment and materials, and supporting overall laboratory operations in compliance with company safety and quality standards. This position is ideal for an early-career scientist seeking hands-on experience in a fast-paced analytical laboratory environment. Essential Functions: Analytical Testing &amp; Data Generation Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques). Prepare samples, reagents, standards, and buffers according to established protocols. Execute assays following approved methods and standard operating procedures (SOPs). Accurately document experimental procedures, observations, and results in laboratory notebooks or electronic systems. Perform basic data analysis and assist in summarizing results for review by senior staff. Troubleshoot routine assay and instrument issues with guidance as needed. Laboratory Operations &amp; Instrumentation Coordinate instrument service and maintenance activities as required. Manage inventory of laboratory supplies, reagents, and consumables; assist with ordering and restocking. Support laboratory organization and cleanliness in accordance with safety and regulatory standards. Assist in drafting or revising SOPs and technical documents as needed. Safety &amp; Compliance Follow all company environmental health and safety (EHS) policies and laboratory best practices. Handle chemicals and biological materials safely and in compliance with applicable regulations. Ensure proper waste disposal and adherence to hazardous material handling procedures. Support inspection readiness and compliance activities where applicable (e.g., GLP/GMP). Requirements:&nbsp; Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline with 0-2 relevant laboratory experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered. Basic understanding of analytical chemistry or biochemistry principles. Familiarity with laboratory instrumentation and data analysis software. Strong organizational skills and attention to detail. Ability to follow detailed instructions and maintain accurate documentation. Effective written and verbal communication skills. Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data Ability to work independently on routine tasks and collaboratively within a team environment. Ability to work in a laboratory environment for extended periods. Use of personal protective equipment (PPE) required. Reports to:&nbsp;Associate Director, Analytical Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $84,000 - $98,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist I, Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team.&nbsp;The Scientist II, Analytical Development, is responsible for executing analytical testing and contributing to analytical method development activities for biologics/vaccine development programs. This role performs routine and non-routine analytical assays using modern analytical techniques, supports method optimization and troubleshooting efforts, and contributes to continuous improvement initiatives with moderate supervision while partnering effectively with cross-functional teams. The position requires demonstrated hands-on laboratory experience, strong technical execution, and problem-solving skills, with the ability to independently plan and execute assigned work, analyze and interpret data, and escalate and/or drive investigations as needed. This role authors and maintains clear technical documentation, including method protocols, method development summaries, and SOPs, and communicates experimental results and conclusions to internal stakeholders. Essential Functions: Method Development &amp; Troubleshooting Contribute to method development, optimization, and qualification/validation readiness activities. Design and execute experiments to evaluate critical method parameters and define appropriate system suitability and control strategies. Troubleshoot assay and instrument performance issues using a structured approach; interpret data to identify likely root causes, implement corrective actions, and document outcomes and recommendations. Support and/or execute method transfer activities, including protocol preparation, training support, execution at receiving labs, and resolution of transfer issues. Author and revise analytical methods, SOPs, protocols, and technical reports; ensure clear documentation of experimental rationale, results, and conclusions for internal review and stakeholder communication. Team Collaboration Partner effectively with cross-functional teams to define analytical plans, meet project timelines, and deliver high-quality outputs. Communicate experimental progress, data interpretation, and emerging risks clearly; propose mitigation plans and align next steps with stakeholders. Contribute to a compliant, safety-focused, and scientifically rigorous lab culture, model good documentation practices and data integrity expectations. Train and mentor junior staff/new team members on assays, workflows, and troubleshooting; provide day-to-day technical guidance and feedback. Analytical Testing &amp; Data Generation Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical/biophysical techniques). Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable); identify and troubleshoot common issues. Perform data processing and interpretation; summarize results, trends, and potential risks, and escalate complex findings for review and decision-making. Maintain accurate, timely documentation in laboratory notebooks or electronic systems; contribute to clear technical communications to project and cross-functional stakeholders. Laboratory Operations &amp; Instrumentation Coordinate routine instrument maintenance and service activities; interface with vendors as needed and support timely issue resolution. Ensure laboratory organization, cleanliness, and compliant material labeling/storage practices. Manage inventory of reagents, standards, and consumables; initiate procurement, track critical supplies, and support forecasting to avoid stockouts. Safety &amp; Compliance Follow all Environmental Health &amp; Safety (EHS) policies and laboratory safety practices. Handle chemicals and biological materials safely and in compliance with regulatory requirements. Ensure proper waste disposal and adherence to hazardous material handling procedures. Support audit and inspection readiness activities where applicable. Requirements:&nbsp; PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 2-5 years; MS with 7+ years; BS with 10+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered. Strong hands-on experience with multiple analytical techniques, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, Liquid chromatography, Mass Spectrometry, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, and PCR. Experience independently driving method development or optimization activities preferred. Strong knowledge of analytical chemistry/biochemistry principles with demonstrated application to assay development and control strategies. Proven ability to independently troubleshoot non-routine assay and instrument issues using structured root-cause analysis and data-driven decision making. Proficient with analytical software, data processing workflows, and statistical tools. Strong scientific judgment and attention to detail consistently produces high-quality, inspection-ready documentation. Ability to independently plan and prioritize work, manage multiple projects, and meet timelines with minimal supervision. Clear and effective written and verbal communication; able to summarize complex data, present recommendations, and collaborate across functions. Ability to work in a laboratory environment for extended periods. Ability to lift up to 25 lbs. Use of personal protective equipment (PPE) required. Contribute to a positive, inclusive, and safety-focused laboratory culture. Reports to:&nbsp;Associate Director, Analytical Development, Raw Materials &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $146,000 – $171,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist II, Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team.&nbsp;The Senior Scientist, Analytical Development, is responsible for leading analytical method development activities for biologics/vaccine development programs. This role designs and drives method development, performs and oversees routine and non-routine analytical assays using modern analytical techniques, and leads method optimization, troubleshooting, and continuous improvement initiatives with minimal supervision, including mentoring and technical guidance to junior team members. The position requires demonstrated hands-on laboratory experience, deep technical expertise, and strong problem-solving skills, with the ability to independently plan and execute work, interpret complex data, and drive investigations to root cause and resolution. This role also authors, reviews, and maintains high-quality technical documentation, including method protocols, method development reports, qualification documentation, SOPs, and clear technical summaries that communicate experimental findings and conclusions to internal and external stakeholders. Essential Functions: Method Development &amp; Troubleshooting Provide technical leadership and strategic direction for method development, optimization and qualification/validation readiness. Define development strategies and experimental roadmaps, identify critical method attributes, set robustness/qualification approaches, and drive alignment with program and regulatory expectations. Lead complex troubleshooting and investigations across assays and instrumentation; establish root-cause and preventive controls, and mentor others in problem-solving. Lead authorship and review of methods, SOPs, protocols, and technical reports; set documentation standards and ensure consistency and readiness for audits/inspections. Team Collaboration Serve as a cross-functional technical leader, aligning analytical strategy with program objectives and driving execution against key milestones and deliverables. Proactively identify, communicate, and manage technical risks and resourcing constraints, influence decision-making with clear options, tradeoffs, and recommendations. Champion a culture of scientific excellence, compliance, and continuous improvement; establish best practices and drive adoption across the team. Lead capability building through mentoring, training programs, and coaching; develop team members’ technical depth, problem-solving, and communication skills. Laboratory Operations &amp; Instrumentation Promote efficient, compliant laboratory operations, including organization, cleanliness, and material control, aligned with applicable quality expectations. Provide oversight and prioritization for instrument maintenance, qualification, and service activities; serve as a technical point of contact for Lab operation team and vendor interactions and complex instrument issues. Ensure continuity of lab readiness by overseeing inventory strategy for reagents, standards, and consumables; support budgeting/forecasting and drive improvements to procurement and inventory processes. Analytical Testing &amp; Data Generation Lead routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques). Maintain accurate and timely documentation in laboratory notebooks or electronic systems. Perform data processing and interpretation; draw conclusions, and clearly communicate outcomes, risks and recommendations to program and cross-functional stakeholders. Safety &amp; Compliance Follow all Environmental Health &amp; Safety (EHS) policies and laboratory safety practices. Handle chemicals and biological materials safely and in compliance with regulatory requirements. Ensure proper waste disposal and adherence to hazardous material handling procedures. Support audit and inspection readiness activities where applicable. Requirements:&nbsp; PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 5+ years; MS with 10+ years; BS with 13+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered. Extensive hands-on experience across a broad analytical technique, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, Liquid chromatography, Mass Spectrometry, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, and PCR. Experience leading method development or optimization activities preferred. Deep expertise in analytical chemistry/biochemistry with broad understanding across platforms. Recognized technical leader in troubleshooting complex, cross-cutting assay/instrument/system issues; drives investigations to root cause and establishes preventive controls. Advanced capability in data analysis and interpretation, including method performance characterization, statistical evaluation, and automation/standardization of data workflows where appropriate. Exemplary quality mindset and documentation rigor; authors/sets standards for methods, protocols, reports, and ensures audit/inspection readiness. Demonstrated ability to lead multiple priorities and influence program direction; effectively resource-plans, remove blockers, and mentor others to deliver results. Excellent communication skills: effectively communicate risk, options, and recommendations to stakeholders and leadership, and align cross-functional teams on path forward. Ability to work in a laboratory environment for extended periods. Ability to lift up to 25 lbs. Use of personal protective equipment (PPE) required. Contribute to a positive, inclusive, and safety-focused laboratory culture. Reports to:&nbsp;Associate Director, Analytical Development, Raw Materials &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $165,000 - $193,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Scientist, Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team.&nbsp;The Associate Scientist II, Analytical Development, is responsible for executing analytical testing and supporting method development activities for biologics/vaccine development programs. This role will perform routine and non-routine analytical assays using modern analytical techniques and will contribute to method optimization, troubleshooting, and continuous improvement initiatives under supervision. The position requires demonstrated hands-on laboratory experience, strong technical execution, and the ability to work independently on routine tasks while supporting more complex development activities. Essential Functions: Analytical Testing &amp; Data Generation Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical or biophysical techniques). Prepare samples, reagents, standards, and buffers according to established protocols. Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable). Perform data processing and preliminary interpretation; summarize findings for review by senior scientists. Maintain accurate and timely documentation in laboratory notebooks or electronic systems. Method Development &amp; Troubleshooting (Under Supervision) Support method development, optimization, and qualification activities under the guidance of senior scientists. Assist in designing experiments to evaluate method parameters and robustness. Troubleshoot assay performance issues and instrument-related problems, proposing potential solutions for review. Participate in method transfer activities, including protocol execution and documentation. Contribute to drafting and revising analytical methods, SOPs, protocols, and technical reports. Laboratory Operations &amp; Instrumentation Coordinate instrument service activities and assist with vendor interactions as needed. Ensure laboratory organization, cleanliness, and proper material storage. Manage inventory of reagents, standards, and consumables; assist with procurement and restocking. Safety &amp; Compliance Follow all Environmental Health &amp; Safety (EHS) policies and laboratory safety practices. Handle chemicals and biological materials safely and in compliance with regulatory requirements. Ensure proper waste disposal and adherence to hazardous material handling procedures. Support audit and inspection readiness activities where applicable. Team Collaboration Collaborate with cross-functional teams to support project timelines and deliverables. Provide clear communication on experimental progress, risks, and results. Contribute to a positive, compliant, and scientifically rigorous laboratory culture. May assist in training junior staff or new team members on routine assays and lab practices. Requirements:&nbsp; Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline with 2+ years, or Master’s degree with 1+ years of relevant laboratory experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered. Hands-on experience with analytical techniques such as chromatography, electrophoresis, or immunoassays is required. Experience supporting method development or optimization activities preferred. Solid understanding of analytical chemistry or biochemistry principles. Experience with method troubleshooting and data interpretation. Familiarity with analytical software and data analysis tools. Strong attention to detail and organizational skills. Ability to work independently on routine assignments and manage multiple tasks. Effective written and verbal communication skills. Ability to work in a laboratory environment for extended periods. Ability to lift up to 25 lbs. Use of personal protective equipment (PPE) required. Contribute to a positive, inclusive, and safety-focused laboratory culture. Reports to:&nbsp;Senior Scientist, Analytical Development for Raw Materials &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $105,000 – $123,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a highly energetic, talented, pro-active, and self-motivated individual to join our growing Facilities and Lab Operations Team. The Lab Manager is a very hands-on role and is responsible for the overall daily operations in Vaxcyte laboratories including vendor management, lab supply inventory, equipment maintenance requirements, and new equipment orders. The Lab Manager is a critical point of contact for lab personnel, fielding service requests, triaging and assigning tasks, providing training, and helping to maintain a culture of safety and compliance. They will support general lab space equipment layouts. They will work with appropriate departments on the development of necessary SOPs for training, equipment maintenance, calibration, and repair. They will work closely with procurement and the lab teams on CAPEX / OPEX budgeting and ordering of lab assets and service contracts. They will support installations in lab spaces, and oversight of any qualification / validation verification activities. They will provide feedback on lab efficiency, operations, and policies as well as recommendations on any necessary changes or improvement. This role will be instrumental in ensuring our facilities and lab operations department and laboratories are ready for growth with Vaxcyte’s current and projected product pipelines. This department enables the labs to run efficiently and the scientists to focus on delivering their respective pipelines. This role will own this department’s transformational journey including centralizing lab operations, standardizing common services, consolidating supplies, implementation of GMP and contracts and application of lean lab techniques (e.g., 5S, Kanban, visual management).&nbsp; A successful candidate is well organized, flexible, creative and enjoys the challenges of managing a diverse and energetic office space. This is a full-time, on-site role that reports to the Director of Lab Operations Note: rotational, shared 24x7 support is required of this role. Essential Functions: Establish and maintain an infrastructure to enable a structured laboratory operation. framework across Vaxcyte’s labs including capital plan/expenditures (from forecast to installation), lab equipment and instrumentation (i.e., contracts, maintenance, repair, calibration, upgrade and retiring), and lab consumables (i.e., contracts, procurement, order management, inventory management). Provide strategic direction, technical supervision, and support to the lab operations team who supports day-to-day operations. Lead operational performance reviews and establish business / individual objectives. Drive improvements in service level, efficiency and cost reduction through standardization of common practices, implementation lean lab techniques and utilization of metrics. Create a platform to share ideas within the lab operations team and with clients including the application of best practices. Establish relationships and service standards and coverage to meet lab-based personnel’s needs. Establish and own a laboratory business continuity plan as well as extended-hours coverage and response plan. Build and improve relationships with partners (i.e., Research Associates, Scientists) and key functions within Vaxcyte (i.e., Project Management, Procurement, Legal, Accounts Payable) through proactive engagement and communication. Develop and realize a service model with clear roles and responsibilities and decision making. Accountable for overall delivery and performance across lab operations. In Collaboration with lab leadership, proactively identify and resolve risks/issues. Responsible for developing and executing a strategy for servicing laboratories, including equipment and instrumentation, scheduling, and lab capacity utilization. Establish relationships and service standards and coverage to meet lab-based personnel’s needs. Support the development, budgeting, and execution of a three (3) year capital project plan. Establish common practices to obtain quotes, submit contract for legal review, place orders, prepare for location set-up (Preparation of bench space, request IT support on computer and network, request Facilities support on utilities), manage equipment delivery, installation, and set-up for use. Establish and manage a common model and contracting strategy across lab operations for equipment preventative maintenance/calibrations/repair, asset utilization, asset surplus redeployment, system upgrade, and retiring with customers, Lab Operations staff, and third-party vendors, to create and manage a list of equipment that is in use and also that scientists can have ready access to Lab Consumables &amp; Critical Supplies. Work with laboratory staff and third-party vendors, to create and manage a master list of managed items onsite (by vendors and internally), stock locations, and stock levels to ensure that scientists have ready access to all basic consumables, critical materials. Partner with key stakeholders to develop and continuously strive for a proactive, high bar safety culture. Work with EH&amp;S Manager to manage EH&amp;S programs at the site to include, but not limited to, Incident Management, Ergonomics, Exposure Risk Assessments, Chemical Hygiene, Hazard Communication, Biosafety Management, Respiratory Protection, Hearing Conservation and Personal Protective Equipment (PPE), etc. Work with EH&amp;S Manager to ensure the site is compliant with all environmental and safety regulations, including Federal, State and/or City regulations. Requirements:&nbsp; Bachelor’s degree in Science or Engineering related discipline with 7 years of progressive experience in operational leadership in R&amp;D and GMP/GLP laboratory, biotechnology or pharmaceutical environment. 3+ years of proven success leading teams of lab operations staff or vendors. Other combinations of education and/or experience may be considered. Proven track record in managing and scaling lab operations. Understand laboratory supply streams, waste streams, and have experience working in an R&amp;D and GMP and GLP laboratory environment. Is known for being highly customer service oriented and has a track record of anticipating the needs of all customers, including bench scientists. Demonstrated drive, curiosity, scientific rigor, and excellent problem-solving skills across a fast-paced performance driven environment. Ability to operate effectively at both an operational and strategic level. Ability to constructively challenge, improve and develop lab operations practices and processes. Self-motivated with the proven ability to take ownership and deliver results in an environment with ambiguity and change. Ability to collaborate cross functionally and align stakeholders to a common problem or solution. Superior communication and interpersonal skills – Oral, written and formal presentation skills. Demonstrated ability to develop new lab operations practices (from a blank sheet of paper) and standard operating procedures. Highly effective communication and organization skills. Proven collaboration and teamwork skills and experience in a fast-paced environment. Creative and proactive problem solver; keen ability to anticipate needs in a lab environment, solving problems with sound judgment.Experience managing and prioritizing inputs from diverse stakeholders to deploy a plan that meets the needs of the business. Proficiency planning and managing small projects. Proficient in GMP, GLP, and GDP. Reports to: Director, Lab Operations &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $128,000 - $150,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Lab Manager

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for a Scientist-II, Conjugation Development. The candidate’s primary responsibility will be to lead and execute experimental activities that support company’s pneumococcal conjugate vaccine program with a focus on developing a deeper understanding of the conjugation process. In parallel, the candidate will work on conjugation process development for Vaxcyte’s pipeline programs contributing to process optimization, scalability, and technical readiness for future clinical manufacturing. Specifically, this will include preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The ideal candidate will have significant laboratory experience and an excellent understanding of analytical chemistry principles. The successful candidate will be expected to design, execute, and troubleshoot experiments with minimal guidance. The candidate will also contribute when needed to a range of related areas such as analytical development and stability studies. Responsibilities will additionally include record management, data presentation at group meetings, authorship of laboratory protocols and development reports, communication with external organizations during tech transfer, and assumption of a leadership role in collaborative studies with other members of the conjugation group. Essential Functions: • &nbsp; &nbsp;Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.• &nbsp; &nbsp;Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).• &nbsp; &nbsp;Analyze polysaccharides and conjugates with a variety of analytical methods. Develop new laboratory workflows and analyses beyond established procedures when appropriate.• &nbsp; &nbsp;Advise team members on experimental design, interpretation of results, and troubleshooting.• &nbsp; &nbsp;Model and train team members on best practices for adherence to protocols and data management.• &nbsp; &nbsp;Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.• &nbsp; &nbsp;Maintain highly organized records to enable optimization and assessment of reproducibility.• &nbsp; &nbsp;Attend team meetings ready to provide updates on conjugation development progress. Requirements:&nbsp; • &nbsp; &nbsp;PhD in chemistry, biochemistry, or related field with minimum 2 years of industry experience, or combination of industry and postdoctoral research; MS with minimum 7 years industry experience, or BS with minimum 10 years of experience industry.• &nbsp; &nbsp;Strong biochemistry and organic chemistry knowledge base underpinning several years’ experience preparing bioconjugates.• &nbsp; &nbsp;Proficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration.• &nbsp; &nbsp;Proficiency in a variety of techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS.• &nbsp; &nbsp;Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods.• &nbsp; &nbsp;Experience with Design of Experiments is desirable.• &nbsp; &nbsp;Experience with chemical modification of polysaccharides is desirable.• &nbsp; &nbsp;Experience implementing and/or using electronic notebooks is desirable.• &nbsp; &nbsp;Attention to detail and excellent organizational skills.• &nbsp; &nbsp;Strong interpersonal skills; ability to communicate effectively both verbally and in written formats.• &nbsp; &nbsp;Self-starter; ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members.• &nbsp; &nbsp;Enthusiasm to learn the new skills and techniques necessary to tackle problems outside of current area of expertise.• &nbsp; &nbsp;This is lab based role that requires an onsite presence.&nbsp; Reports to: Associate Director, Conjugation Development &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $146,000 - $170,000 (SF Bay Area).&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist II, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Director, Health Economics &amp; Outcomes Research (HEOR) to establish and lead the company’s health economic strategy across the vaccine lifecycle, with initial focus on adult pneumococcal programs.&nbsp;This strategic leadership role will be responsible for developing and executing global health economic models to support payer value propositions, immunization policy engagement, reimbursement strategy, and external stakeholder communications. This role will focus specifically on health economic modeling and payer value strategy. Observational real-world evidence and epidemiology studies will be led by the Epidemiology &amp; Real-World Evidence function. The Director, HEOR will work in close collaboration with RWE and Epidemiology colleagues to ensure economic models are grounded in robust disease burden, vaccine effectiveness, and coverage assumptions. As Vaxcyte advances toward commercialization, this role will partner closely with Market Access colleagues, who will lead pricing and contracting strategy. The Director, HEOR will provide the analytic foundation and economic evidence required to inform pricing strategy, payer engagement, and health technology assessment discussions. Essential Functions: Health Economic Strategy &amp; Leadership Develop and lead Vaxcyte’s HEOR strategy across early development, launch planning, and lifecycle management. Define the economic evidence generation plan required to support payer access and policy recommendations. Ensure health economic considerations are incorporated early into development planning. Health Economic Modeling Lead development of cost-effectiveness, budget impact, and population health models for adult and pediatric vaccine programs. Design and oversee decision-analytic models (e.g., Markov models, microsimulation models, dynamic transmission models as appropriate). Establish modeling assumptions grounded in epidemiologic, clinical, and real-world data. Ensure all models are scientifically rigorous, transparent, and defensible in policy and payer environments. Value Communication &amp; Policy Support Translate health economic findings into clear, compelling value narratives for internal leadership and external stakeholders. Support development of global value dossiers, AMCP dossiers, and materials for payer engagement. Contribute to peer-reviewed publications and scientific congress presentations. Cross-Functional Partnership Partner closely with Epidemiology &amp; RWE to integrate disease burden and vaccine effectiveness assumptions into economic models. Collaborate with Clinical Development, Regulatory, Medical Affairs, and Market Access teams to align value strategy. Support consistent, aligned value messaging across stakeholders. Capability Building Establish best practices and governance processes for health economic modeling. Build and manage external modeling partnerships. Mentor future HEOR team members as the function expands. Requirements:&nbsp; PhD in Health Economics, Health Services Research, Public Health, Epidemiology, or related quantitative field with 8+ years of relevant industry experience required OR Master’s degree (e.g., MPH, MSc, MBA) with 12+ years of relevant industry experience in health economic modeling. Demonstrated experience leading cost-effectiveness and budget impact models. Deep expertise in decision-analytic modeling methodologies. Experience supporting payer submissions or health technology assessments. Strong cross-functional leadership and communication skills. Reports to: Vice President, Scientific Affairs &amp; Epidemiology &nbsp; Location: &nbsp;San Carlos, CA/Remote (US) &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $242,000 – $282,000 *(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Health Economics & Outcomes Research (HEOR)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly experienced Senior Software Engineer with deep full-stack expertise and a strong DevOps orientation. This individual will play a key role in designing, building, testing, and operating scalable web applications that support critical business functions. The ideal candidate combines strong frontend and backend development capabilities with a disciplined approach to automation, testing, CI/CD, and production reliability. This role requires technical leadership, architectural judgment, and the ability to drive engineering excellence across the software lifecycle. Essential Functions: Full-Stack Application Development Architect, design, and implement scalable applications using Next.js and React Develop and maintain backend services and GraphQL APIs, including schema design and performance optimization Ensure high standards for code quality, security, performance, and maintainability Participate in architectural design reviews and technical decision-making Testing &amp; Quality Engineering Lead implementation of comprehensive automated testing strategies, including: End-to-end UI testing (e.g., Playwright, Cypress) API and integration testing Unit and regression testing Establish and enforce best practices for test coverage and quality gates Improve system stability through proactive quality engineering practices DevOps &amp; Continuous Delivery Design, implement, and optimize CI/CD pipelines using GitHub Actions Automate build, test, and deployment workflows across environments Improve release reliability, deployment frequency, and rollback strategies Contribute to monitoring, logging, and observability improvements Support production systems and participate in incident resolution when needed Technical Leadership Mentor engineers and provide guidance on architecture and best practices Contribute to engineering standards and documentation Drive continuous improvement in development processes and tooling Collaborate cross-functionally with Product, Design, and Infrastructure teams Requirements:&nbsp; Bachelor’s degree in Computer Science, Engineering, or related field (or equivalent experience) Minimum 5 years of professional software engineering experience and a minimum of 4 years of experience in modern frontend frameworks, including Next.js and React. Other combinations of education and/or experience may be considered. Strong experience designing and implementing GraphQL APIs Proven experience in full-stack system architecture and development Demonstrated experience implementing automated testing for UI and APIs Hands-on experience building and maintaining GitHub Actions CI/CD workflows Strong understanding of DevOps principles, continuous delivery, and production system reliability Experience working with scalable, production-grade applications Excellent communication skills and ability to lead technical initiatives Preferred Qualifications Experience deploying and managing applications in Microsoft Azure Experience with Terraform or other Infrastructure-as-Code solutions Familiarity with containerization (Docker) and modern deployment patterns Experience with monitoring and observability platforms Familiarity with AI-assisted development tools such as ChatGPT, Claude, or similar platforms Experience integrating AI APIs or intelligent automation into applications Strong architectural and systems design capability Ownership mindset with accountability for outcomes Commitment to automation and operational excellence Ability to balance technical rigor with delivery timelines Continuous learner who leverages modern tools, including AI-assisted development Other combinations of education and/or experience may be considered. Reports to:&nbsp;Associate Director, Data Systems, CMC IT &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $191,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Software Engineer

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: As Vaxcyte’s products progress towards late stage and commercialization, Vaxcyte is implementing dedicated biologics manufacturing facilities. This contract position will support all aspects of process systems engineering activities related to commercial launch, and routine GMP manufacturing to ensure the efficient and compliant production of Vaxcyte's products. The Sr. Engineer, Process Systems (Contract) will work closely with Process Development, MSAT, Supply Chain, Quality, Project Management, Business Development, and Regulatory functions, as well as CDMOs. This role is responsible for leading and overseeing process systems-related activities for biologics manufacturing facilities, systems, and equipment. As a technical leader within the field, the Sr. Engineer, Process Systems (Contract) ensures that all processes and systems comply with regulatory and company standards, contributes to the development of company concepts &amp; principles and solves complex problems in creative and effective ways. The role involves collaborating with cross-functional teams to support new installations, system upgrades, and ongoing operations. Effective cross-functional teamwork and successful engagement with CDMOs are critical to success in this position. This position will report to the Director of Engineering &amp; Facilities at Vaxcyte. Essential Functions: Process System Owner: Lead and manage all engineering activities for advanced biotechnological systems, including utilities, process equipment, automation systems, and facilities. Work on significant and unique issues where analysis of situations or data requires an evaluation of intangible variables and may impact future concepts, products or technologies. Review and approve process equipment documentation, such as protocols, test plans, reports, and other deliverables, ensuring alignment with company standards and regulatory requirements. Conduct comprehensive risk assessments and design strategies to validate and optimize critical process parameters in compliance with industry standards and regulatory guidelines. Lead complex system and equipment inspections, including FATs (Factory Acceptance Tests), SATs (Site Acceptance Tests), and IQ/OQ/PQ (Installation Qualification/Operational Qualification/Performance Qualification), ensuring precision and compliance. Lead engineering feasibility studies, conceptual &amp; basic design activities for projects across a range of products and sites. Validation: Direct and manage validation initiatives, ensuring compliance with cGMP, FDA, EMA, and other applicable regulatory agencies. Oversee the review and approval of validation protocols, plans, and reports, ensuring their alignment with industry standards and ensuring robust and reliable processes. Analyze complex validation data to identify critical trends, continuously improving the reliability, efficiency, and compliance of validated systems. Project Management: Create formal networks with key decision makers and interface with CDMO and supplier partners. Oversees the activities of a project and teams involved in cross-functional engineering projects from conception through completion, balancing complex timelines, budget constraints, resource allocation, and quality standards. Collaborate effectively with senior project managers, cross-functional teams, contractors, and external vendors to coordinate, prioritize, and execute engineering activities. Ensure project deliverables are met within scope and timeline while maintaining focus on compliance, quality, and cost-effectiveness. Regulatory Compliance: Ensure full regulatory compliance of all systems with FDA, EMA, and other global regulatory requirements. Lead and support regulatory inspections, audits, and customer site visits, including presenting documentation and addressing regulatory concerns with senior leadership. Monitor, interpret, and incorporate changes in regulatory guidelines, ensuring Vaxcyte’s engineering processes are continuously aligned with evolving standards. Leadership and Strategy: Exercise latitude in determining objectives and approaches to critical assignments. Drive strategic improvements in engineering processes, tools, and methodologies, ensuring the continuous optimization of systems and compliance practices across the organization. Collaborate with senior leadership to define long-term engineering strategies and goals, ensuring alignment with organizational objectives and growth plans. Lead the transition from capital project implementation to ongoing engineering support for commercial manufacturing, emphasizing preventive maintenance, continuous improvement, equipment upgrades, and the integration of evolving industry standards to ensure operational efficiency and compliance. Take accountability for complex projects, scopes of work and technical troubleshooting. Drive strategic alignment, standardization and adoption of engineering lifecycle management programs with CDMOs and partners. Requirements:&nbsp; Bachelor’s or Master’s degree in Engineering (Chemical, Mechanical, Biomedical, or related field) or Biotechnology with a minimum of 10+ years of experience in Bioprocessing/Process Engineering within the biotechnology, pharmaceutical, or biopharmaceutical industry. Proven leadership experience in managing teams and large-scale Capex projects, including utilities, process equipment, and automation systems. Extensive knowledge of biopharmaceutical manufacturing processes and equipment, particularly DCS, ISA-88 batch process control, and PLC-based control systems. Demonstrated success in managing engineering activities for large-scale or complex facilities under tight timelines and budget constraints. Expert-level knowledge of cGMP, FDA, EMA, ICH guidelines, and other global regulatory requirements. Strong understanding of bioprocessing, including upstream and downstream processing, aseptic processing, and sterilization techniques. Advanced proficiency in statistical analysis, risk assessment methodologies, and process validation best practices. In-depth experience with quality management systems (QMS) and electronic documentation systems to maintain compliant documentation and support audit activities. Capability to support and, when required, perform a range of broader engineering functions and activities, including project management, process optimization, automation, and utilities engineering. Exceptional leadership, communication, and interpersonal skills, with the ability to influence at all levels of the organization and external partners. Strong problem-solving, analytical thinking, and decision-making capabilities, especially in high-pressure environments. Ability to prioritize and manage multiple complex projects, balancing conflicting demands while ensuring regulatory compliance and business goals. Reports to: Director of Engineering &amp; Facilities &nbsp; Location: Visp, Valais, Switzerland &nbsp; Expected Contract Length:&nbsp;12 Months &nbsp; &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Sr. Engineer, Process Systems (Contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly motivated and detail-oriented Senior Associate Scientist (Contract) to join our Polysaccharide team. Primary responsibility for the incumbent will be to support analytical testing and characterization of polysaccharide-based drug candidates. This individual will execute and optimize a variety of biochemical and chromatographic assays, contribute to method development initiatives, and ensure high-quality data generation in support of research and development programs. &nbsp; This role requires strong hands-on experience in HPLC-based techniques, biochemical assays, and analytical software platforms, along with a commitment to data integrity, documentation excellence, and cross-functional collaboration. Essential Functions:&nbsp; Analytical Testing &amp; Characterization Perform in-house assays for polysaccharide manufacturing, including in-process testing, process development and process characterization study sample analysis, including: HPLC-based assays (e.g., HPLC-RI, HPAEC-PAD, etc.) Spectrophotometric-based assays (e.g., UV/Vis, Lowry, PicoGreen, Anthrone, etc.) Enzyme- and/or Immuno assays (e.g., ELISA, MSD platforms) Nephelometry (e.g. Turbidity analysis) Metabolite Analysis (e.g. sugars) LC-MS-based assay Prepare samples, reagents, standards, and controls according to established protocols. Troubleshoot instrumentation and assay performance issues to ensure reliable data output. Method Development &amp; Optimization Assist in developing, qualifying, and optimizing analytical methods for sample preparation, testing, and characterization. Support method transfer, robustness evaluation, and documentation updates. Proactively recommend improvements to increase assay sensitivity, reproducibility, and throughput. Data Analysis &amp; Reporting Utilize data analysis software platforms such as Empower and Chromeleon for HPLC data acquisition and analysis, and SoftMax Pro for MSD and spectrophotometric assay data analysis. Analyze, interpret, and summarize experimental data clearly and concisely. Prepare technical summaries and present findings to cross-functional teams (e.g., R&amp;D, CMC, Quality). Compliance &amp; Documentation Maintain meticulous laboratory notebooks and electronic records in compliance with internal SOPs and laboratory standards. Ensure data integrity and adherence to applicable regulatory guidelines (e.g., GLP/GMP where applicable). Participate in audits, documentation reviews, and quality initiatives as needed. Collaboration &amp; Continuous Learning Collaborate effectively with scientists across disciplines to support program milestones. Demonstrate eagerness to learn new analytical techniques and scientific concepts. Integrate best laboratory practices and contribute to a culture of operational excellence. Requirements: MSc in Chemistry/Biochemistry, Biotechnology, or similar degree with a minimum of 3 years of relevant industry experience, or BSc with a minimum of 5 years of relevant industry experience. Hands-on experience with HPLC systems and carbohydrate or polysaccharide analysis. Experience with HPAEC-PAD is preferred. Experience with LC-MS/MS is a plus. Experience with Empower and/or Chromeleon software. Familiarity with biochemical assays (ELISA, colorimetric, fluorescence-based assays). Experience working with polysaccharides, biologics, or complex drug substances. Experience in in-process monitoring and testing for process-related impurities. Knowledge of regulatory expectations for analytical documentation. Experience supporting CMC, process development, or analytical development programs. Strong organizational skills and attention to detail. Excellent written and verbal communication skills. Strong analytical and problem-solving skills. High attention to data accuracy and reproducibility. Ability to manage multiple priorities in a fast-paced environment. Collaborative team player with proactive communication style. Continuous improvement mindset. Reports to: Senior Scientist, Polysaccharide Analytical Development Location: San Carlos, CA Expected Contract Length:12months Hourly Range: $56.00/hr. - $62.00/hr.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist (contract), Polysaccharide Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for a Senior Manager, Quality Control Data Analyst to join our QC organization to act as a bridge between our technical QC Operations team and Business teams.&nbsp; This individual will be responsible for the collection, evaluation, interpretation, and visualization of complex datasets to provide actionable insights that drive technical and business decisions. Key responsibilities include creating reports, maintaining databases, and using tools to identify trends, initiate quality events if needed, improve efficiency, and support definition of acceptance criteria as well as strategic planning. Essential Functions: Work closely with the analytical sub teams and other functions within Analytics, Process Development, Quality Assurance, Operations, and Regulatory functions. Accountable for data integrity, accuracy, and reliability as well as that datasets are assessed in a timely manner and meet quality and regulatory standards to ensure secure and uninterrupted supply of Vaxcyte’s innovative therapies. Develop, implement, and maintain leading-edge analytics systems, taking complicated problems and building simple frameworks. Evaluate internal systems for efficiency, problems, and inaccuracies with regard to data collection and evaluation, and develop and maintain processes and SOPs for handling, evaluation, and visualization of complex data sets. Lead activities in QC Operations with regards the data warehousing and data mining programs underway (VaxData). Create and maintain rich interactive visualizations through data interpretation and analysis, with reporting components from multiple data sources. Define and implement data acquisition and integration logic, selecting an appropriate combination of methods and tools within the defined technology stack to ensure optimal scalability and performance of the solution. Develop and maintain databases by acquiring data from primary and secondary sources, and build scripts that will make our data evaluation process more flexible or scalable across datasets. Implement, and maintain robust quality control systems that encompass data mining, analysis, and visualization Follow prescribed systems for data management, including secure storage, retrieval, and retention of QC data and documentation are in place. Ensure that all testing activities are well-documented and comply with Good Documentation Practices (GDP). In partnership with the analytical subteams and analytical science and technology, oversee data collection, evaluation and visualization for in-process and release data in order to support monitoring the analytical control strategy and related acceptance criteria. Identify trends to initiate quality events and respective investigations through analysis of complex datasets. Review and approval of analytical data, test reports, and certificates of analysis (CoAs) generated by contract laboratories to verify accuracy, completeness, and compliance with specifications for both in-process and release testing. Act as point of contact with IT for QC operations. Support investigations and deviations, out-of-specification (OOS), out-of-trend (OOT), out-of-expectation (OOE) results, laboratory incidents, and customer complaints collaborating with internal stakeholders to implement corrective and preventive actions (CAPAs) as a data Subject Matter Expert. Writing, review and approval of documents related to Quality Control, Computer System Validation, and GAMP5 to ensure compliance with applicable regulatory and industry standards. Work directly with managers and users to gather requirements, provide status updates, and build relationships. Requirements:&nbsp; Bachelor’s degree (or equivalent) in biology, biochemistry or other related science with 8+ years of experience in biotechnology/pharmaceutical industry and 3+ years of experience as data analyst in data science/statistics. Other combinations of education and/or experience may be considered. Proven analytics skills, including mining, evaluation, and visualization. Technical writing experience in relevant areas, including queries, reports, and presentations. Expert level knowledge of the standard MS suite of programs (Excel, Word, VBA, Teams, Access). Strong SQL, with aptitude for learning other analytics tools. Experience with database and model design and segmentation techniques. Practical experience in statistical analysis through the use of statistical packages SPSS, and SAS. Comprehensive knowledge in cGDP and experience in multi-national regulations. Strong analytical and problem-solving abilities, with a focus on data-driven decision-making and continuous improvement. Experience in Quality Control, especially late stage or commercial. Proven success in a collaborative, team-oriented environment. Relentless focus and passion around process improvements (efficiency and automation). Reports to: Director, QC Business Operations &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $166,000 – $194,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Control Data Analyst

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.&nbsp; Summary: Vaxcyte is looking for an energetic and talented individual to join our Drug Product Development team. The candidate must have knowledge of and practical experience in analyzing and characterizing biomolecules (proteins, polysaccharide conjugates, vaccines) using a variety of methods, especially immunoassays and multiplexed immunoassay formats. Experience in analyzing vaccine and adjuvant-containing formulations is a plus. In addition, Vaxcyte is looking for an experienced and flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a lab-based scientific role and requires excellent scientific judgement, independence, rigor, and thorough record-keeping. Essential Functions: Execute routine and non-routine analysis of internal release, development, and stability samples using a variety of analytical techniques across Drug Product working groups, ensuring high-quality data generation and reporting. Support the execution, optimization, and continuous improvement of Vaxcyte’s internal multiplex immunoassay (MSD) assay suite, including troubleshooting assay performance, improving robustness, and supporting assay lifecycle management. Design, execute, and interpret experiments to support non-GxP stability studies including thermal, freeze/thaw, agitation, and container closure system evaluations for both Drug Substance and adjuvanted vaccine Drug Product materials. Analyze and interpret complex assay data, identify trends or deviations, and communicate findings to project teams to support development decisions. Contribute to method development, qualification, and technology transfer activities, including collaboration with external analytical laboratories and manufacturing CMOs. Author and review technical documentation including assay protocols, SOPs, reports, study plans, and technical summaries in support of development and analytical activities. Support the Vaxcyte PCV and VAXA1 programs through cross-functional collaboration with Drug Product Development, Formulation, Analytical Development, Quality, and external partners. Vaxcyte is seeking a flexible and collaborative Scientist comfortable managing multiple priorities in a fast-paced development environment. This role is predominantly lab-based and requires strong scientific judgment, independence in experimental execution, rigor in data analysis, and meticulous record keeping. Requirements:&nbsp; MS degree in Chemistry, Biochemistry, or related field with minimum 5 years of relevant industry experience, or BS degree with minimum 8 years of relevant industry experience. At least 2 years of experience in an analytical development or quality control role. Prior experience running colorimetric assays is required. Prior experience with SEC-MALS is required. Prior experience with SDS-PAGE is required. Excellent attention to detail, organizational skills, and record-keeping abilities. Ability to work both independently and collaboratively in a fast-paced environment. Commitment to integrity, professionalism, and safety in all aspects of work. Reports to: Senior Manager, Drug Product Analytics &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12months&nbsp; Hourly Range: $62.00/hr. - $68.00/hr.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist I (Contract), Drug Product Analytics

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking Senior Associate Scientist (Contract), Conjugation Development, who will support the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on review of analytical data and electronic notebook entries for accuracy and adherence to SOPs. This is a remote, part-time position with flexible working hours that requires strong organizational skills, clear communication, and a high level of attention to detail. Essential Functions: • &nbsp; &nbsp;Review analytical assay data for adherence to SOPs and accuracy.• &nbsp; &nbsp;Review electronic notebook entries for completeness and accuracy.• &nbsp; &nbsp;Track shipping details for vendor-supplied samples.• &nbsp; &nbsp;Draft and update data analysis templates to reflect new and updated analytical methods and for continuous improvement.• &nbsp; &nbsp;Maintain organized records of review status of notebook entries and analytical data.&nbsp;• &nbsp; &nbsp;Contribute to reports, certificates, and other documentation supporting process development.• &nbsp; &nbsp;Collaborate effectively with team members and contribute to cross-functional activities. Requirements:&nbsp; • &nbsp; &nbsp;BS degree in Chemistry, Biochemistry, or related field with minimum 5 years of industry experience, or MS degree with minimum 3 years of industry experience.• &nbsp; &nbsp;At least 2 years of experience in an analytical development or quality control role.• &nbsp; &nbsp;Prior experience running colorimetric assays is required.&nbsp;• &nbsp; &nbsp;Prior experience with SEC-MALS is required.• &nbsp; &nbsp;Prior experience with SDS-PAGE is required.• &nbsp; &nbsp;Excellent attention to detail, organizational skills, and record-keeping abilities.• &nbsp; &nbsp;Ability to work both independently and collaboratively in a fast-paced environment.• &nbsp; &nbsp;Commitment to integrity, professionalism, and safety in all aspects of work. Reports to: Associate Director, Conjugation Development &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12 months&nbsp; &nbsp; Hourly Range:&nbsp;$56.00 - $62.00 (SF Bay Area). Hourly ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist (Contract), Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Buyer, Supply Chain supports the execution of procurement activities for materials and services required to enable manufacturing and supply chain operations in Switzerland and globally.&nbsp;This role is primarily responsible for requisitioning, purchase order management and supplier delivery coordination, ensuring on time delivery from suppliers.&nbsp; In addition, this role may support spend reporting and other project activities within Direct Procurement. The position operates in a regulated biotech environment and works closely with Strategic Sourcing, Supply Chain, Finance, Quality, MSAT and external CDMOs and suppliers to ensure timely, compliant, and cost‑effective purchasing. Essential Functions: Act as primary requisitioner for raw materials and selected globally sourced goods and services. Ensure compliance with approved sourcing strategies, supplier contracts, pricing, and delivery terms. Interface with suppliers to confirm order acknowledgements, lead times, and delivery schedules. Support resolution of order discrepancies, delivery delays, and invoice mismatches. Support spend tracking, reporting, and basic analytics to provide transparency on purchasing volumes and trends. Contribute data for budgeting, forecasting, and supplier performance reviews. Execute procurement transactions in SAP in line with defined processes and internal controls. Support continuous improvement initiatives for procurement workflows, data quality, and reporting. Contribute to ERP and procurement process harmonization efforts across regions. Ensure purchasing activities comply with company policies, Swiss regulatory requirements, and applicable GxP standards. Maintain complete and audit‑ready procurement documentation. Requirements: Commercial education (e.g Federal Diploma), or Bachelor’s degree, in a relevant field, with 3+ years of experience in a Buyer, Procurement, or Supply Chain Operations role. Other combinations of education and/or experience may be considered. Ability to work in a cross-functional matrix organization and coordinate between multiple parties. Experience in biotech, pharmaceutical, life sciences, or similar regulated industry preferred. Hands‑on experience with purchase requisitions, purchase orders, and supplier interaction. Excellent communication, customer service and relationship skills. Excellent analytical skills. Knowledge of ERP, MS Office and other relevant applications. Fluent in English. Fluency in German highly preferred; Italian and other European languages an advantage. Reports to: Associate Director, Strategic Sourcing &nbsp; Location: Visp, Switzerland (hybrid) or Steinhausen, ZG, Switzerland (hybrid) &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Buyer, Supply Chain

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Manager, Quality Assurance, Compliance who is responsible for providing day-to-day operational oversight governance and strategic oversight of key Quality System processes, with a primary focus on leading Change Control governance and deviation/investigation oversight review board leadership. This role insures consistent, risk-based decision making, inspection readiness, and cross-functional accountability across quality systems. The Manager acts as an operational backbone a governance leader for cross-functional quality processes, proactively identifying systemic risks, ensuring procedural compliance, driving performance through KPIs, and presenting quality system health and trends through Management Review. Essential Functions: Change Control Governance &amp; Board Leadership Lead and coordinate the Change Control Review Board (CCRB), including agenda development, facilitation, quorum confirmation, and documentation of decisions. Perform pre-CCRB QA review of Change Requests to ensure completeness, clarity, and appropriate risk classification prior to board review. Verify alignment of Change Requests with applicable SOPs, including confirmation of CCRB-required versus discretionary changes. Provide QA authority on change classification, risk assessment, impact evaluation, and implementation strategy. Own CCRB performance metrics, including cycle time, risk categorization trends, backlog, and recurring impact areas. Present trends and risk signals to senior leadership and during Management Review. Deviation and Investigation Governance Lead or co-lead Deviation Review Boards to ensure consistent, risk-based decision making. Ensure appropriate classification (minor, major, critical) and scientifically sound investigations. Evaluate adequacy of root cause analyses (e.g., 5-Why, Fishbone). Ensure linkage between deviations, CAPA, and change controls to prevent recurrence and address systemic risk. Quality Metrics and Management Review Own development, maintenance, and reporting of Quality System KPIs related to Change Control, Deviations, Investigations, and CAPA. Perform routine trend analysis and signal detection to identify emerging compliance risks. Prepare and present Quality System performance data during Management Review. Inspection Readiness and Regulatory Support Serve as Subject Matter Expert (SME) for Change Control and Deviation processes during regulatory inspections and audits. Support preparation of audit responses and ensure timely and compliant closure of observations. Maintain processes in a continuous state of inspection readiness. Requirements:&nbsp; Bachelor’s degree in Life Sciences or a related field. 5+ years of experience in Quality Assurance within the pharmaceutical, biotechnology, or medical device industry. Other combinations of education and/or experience may be considered. Experience leading cross-functional governance boards strongly preferred. Strong understanding of ICH Q10, risk management principles, and inspection expectations. Experience with electronic Quality Management Systems (eQMS) strongly preferred. In-depth knowledge of cGMP regulations. Excellent organizational skills, attention to detail, and ability to manage multiple priorities. Strong interpersonal and communication skills to work effectively across functions and with external partners. Reports to:&nbsp;Associate Director, QA, Compliance &nbsp; Location: San Carlos, CA; Hybrid &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $151,000 – $176,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Assurance, Compliance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Manager, Supply Chain Management is responsible for day‑to‑day operational execution of supply chain activities supporting Vaxcyte’s clinical, GMP, PPQ, and commercial readiness programs. This role focuses on tactical planning, execution, tracking, and issue resolution across materials, logistics, and external partners, ensuring smooth and compliant operations in support of manufacturing campaigns. The role works closely with the Associate Director, Supply Chain, who retains end‑to‑end strategic ownership across programs, while the Manager, Supply Chain Management ensures disciplined execution, follow‑through, and operational stability. Essential Functions: Operational Supply Chain Execution Execute approved supply chain strategies and plans across GMP, PPQ, and clinical/commercial readiness activities. Manage day‑to‑day material planning, ordering, and tracking to ensure on‑time availability aligned with manufacturing schedules. Support execution of supply activities across multiple programs, with a focus on operational readiness and delivery. Manage and coordinate Critical Raw Materials and Customer‑Supplied Materials provided to Lonza. Materials, Logistics &amp; Vendor Coordination Coordinate shipments and storage with the Logistics Team. Track material movements, inventories, and material status, proactively escalating risks or delays, particularly for Critical Raw Materials. Act as the primary operational interface between Supply Chain and Procurement / Buyer, ensuring alignment between ordered materials, delivery timelines, and campaign execution needs. CDMO &amp; External Partner Support Support operational interfaces with CDMOs, primarily Lonza. Participate in recurring Lonza‑related forums (e.g. VIBEX, MINT material ordering, allocation, and operational alignment meetings). Follow up on action items, timelines, and required documentation to enable smooth execution. Support deviation‑related activities by coordinating information flow between Supply Chain, Quality, and Operations. Tracking, Reporting &amp; Documentation Maintain operational trackers, dashboards, and status updates related to materials, shipments, and readiness. Own the accuracy and maintenance of campaign progression data, including OMP‑related tracking, ensuring consistency across Supply Chain, Manufacturing, and Lonza‑reported data. Support preparation of weekly and recurring campaign updates by providing validated execution‑level data. Issue Resolution &amp; Continuous Improvement Act as a first line of response for operational issues related to materials, logistics, and execution. Escalate issues with clear data, options, and recommendations to the Associate Director. Identify opportunities to improve execution efficiency, tracking, and operational robustness. Requirements:&nbsp; Bachelor’s degree in Supply Chain, Operations, Engineering, Life Sciences, or a related field with 7+ years of experience in Supply Chain Operations, Manufacturing Support, or a related role. Other combinations of education and/or experience may be considered. Experience working in a regulated biotech, pharmaceutical, or life sciences environment. Strong ability to work in a cross‑functional, matrix organization. Hands‑on experience with material planning, logistics coordination, and operational execution. Strong analytical, organizational, and follow‑through skills. Proficiency with ERP systems, SharePoint, and MS Office tools. Fluent in English. Fluency in German highly preferred; other European languages an advantage. Reports to:&nbsp;Associate Director, Supply Chain &nbsp; Location:&nbsp;Visp, Switzerland (hybrid) or Steinhausen, ZG, Switzerland (hybrid) &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; #LI-JN1 We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Supply Chain Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Computer Systems Validation (CSV) Engineer is responsible for leading validation activities for cloud based GxP systems to ensure they meet regulatory, quality, and operational requirements throughout the system lifecycle. The role focuses on traditional Computer System Validation with application of risk-based Computer Software Assurance (CSA) principles where appropriate. The individual will work closely with IT and Quality teams to validate and maintain GxP systems across their lifecycle. Strong experience validating relational databases, cloud infrastructure, and integrated applications in regulated biotech or pharmaceutical environments is required. This is a hands-on role requiring authoring and executing validation documents and protocols for GAMP 5 systems. This is a hybrid role with minimum of 3 days a week onsite at San Carlos, CA location. Essential Functions: Hands-on lead full lifecycle Computer System Validation activities for cloud based GxP systems including databases, and applications. Author, update, execute and maintain validation deliverables such as Validation Plans, User Requirements, Functional Specifications, Risk Assessments, Traceability Matrices, IQ, OQ, PQ protocols, and Summary Reports. Perform risk assessments to define validation scope, testing strategy, and documentation requirements in alignment with CSA principles. Define and execute validation strategies for data platforms and system components, ensuring systems meet defined functional, security, and data integrity requirements Assess and validate end to end data flows between upstream source systems and downstream applications to ensure accuracy, completeness, and traceability. Evaluate system changes for validation impact and ensure validated systems remain compliant through appropriate testing and documentation. Ensure validation activities align with automated build and deployment pipelines, confirming that system releases maintain validated state and appropriate validation evidence is generated. Support change control, deviation management, periodic review, and lifecycle management of validated systems. Participate in internal audits and regulatory inspections, providing validation documentation and rationale as required. Contribute to continuous improvement of validation procedures aligned with evolving CSA guidance and cloud delivery models. Requirements:&nbsp; Bachelor’s degree in Computer Science, Engineering, Life Sciences, or related field, or equivalent professional experience. Minimum 7 years of experience in Computer System Validation within biotech manufacturing and lab data systems. Other combinations of education and/or experience may be considered. Must have technical knowledge of IT infrastructure, software engineering, programming, databases and data integrations. Experience working in modern system environments utilizing CI/CD pipelines or automated release processes. Strong hands-on experience validating GAMP 5 systems for biotech manufacturing. Deep understanding of FDA 21 CFR Part 11, Part 210, Part 211, Annex 11, data integrity requirements, and risk-based validation methodologies. Strong technical writing skills and ability to create comprehensive validation documentation. Ability to communicate validation risks and requirements clearly to IT and Quality stakeholders. Other combinations of education and/or experience may be considered. Preferred Qualifications: Hands-on experience validating cloud based GxP systems, specifically Azure. Familiarity with infrastructure as code frameworks like GitHub, Terraform etc. Experience applying CSA principles to custom data applications in GxP cloud. Microsoft Azure or similar technical certifications. Reports to: Senior Manager, Data Systems &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $164,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Computer Systems Validation Engineer

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is seeking an Associate Engineer II with experience or strong foundational knowledge in vaccine or biologics process development and manufacturing to join the Polysaccharide Clinical Manufacturing/Process Development team. The candidate will provide technical support for manufacturing activities in collaboration with CDMO partners, while also contributing to process development and process validation efforts. The position requires laboratory presence (&gt;50%) and the ability to independently execute and document experiments, analyze data, and communicate results through technical reports and presentations. The successful candidate will collaborate cross-functionally and may interface with external CDMO partners to support manufacturing campaigns and process transfers. Essential Functions: Provide remote manufacturing (MFG) oversight to support batch execution, ensuring adherence to process parameters and GMP requirements Participate in deviation investigations, root cause analysis, and implementation of corrective and preventive actions (CAPAs) Provide technical support for MFG and process development through data analysis, MFG document reviews, and supporting lab scale studies Perform in-process sample testing to support monitoring of MFG process performance and understanding Manage sample inventory, including tracking, storage, and organization of manufacturing samples Maintain accurate and timely documentation in electronic lab notebook (ELN) systems Analyze manufacturing and experimental data using statistical tools (e.g., JMP) and summarize findings in technical reports Collaborate with cross-functional teams including Process Development, Manufacturing, Analytical Development, and Quality Prepare and present technical data to internal stakeholders and support interactions with CDMO partners Requirements:&nbsp; BS in Chemical Engineering, Biochemistry, or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience. Experience or exposure to GMP manufacturing environments and process development activities Hands-on experience with in-process analytical techniques, including colorimetric and enzymatic assays Familiarity with upstream and downstream processing technologies, such as fermentation, UF/DF, depth filtration, and chromatography Experience supporting technology transfer, scale-up, or CDMO-based manufacturing is preferred Understanding of deviation investigations and root cause analysis methodologies Familiarity with statistical analysis tools (e.g., JMP) is preferred Experience using electronic lab notebook (ELN) systems is a plus Strong technical writing, data analysis, and communication skills Reports to: Senior Engineer, MSAT Polysaccharide&nbsp; &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Expected Contract Length: 12months &nbsp; Hourly Range:&nbsp;$48.00hr - $54.00/hr.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Engineer II, Polysaccharide Manufacturing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Lead the strategic sourcing capability within Vaxcyte Technical Operations. Focus will be to ensure that the clinical and commercial supply network can meet the needs of the business. Working closely with Process Development, Commercial Manufacturing, and Supply Chain Planning this position will support the global commercial manufacturing network strategy by analyzing make/buy scenarios, should-cost modeling, identifying vendors, managing competitive bidding, negotiating and executing contracts. To ensure maximum value for Vaxcyte’s supply network they will need to manage performance aspects of vendors and contracts, and coordinates sourcing and procurement activities across departments to ensure that desired goods or services, quality, and performance meet business needs. This role will also work closely with Finance, Project Management and technical department leaders to manage supplier related financial compliance. This role requires the ability to develop and maintain strong collaborative and cooperative working relationships with team members across different functions and at different levels within the organization. The position requires enthusiasm, passion, influence, attention to detail and a desire to deliver great vaccines for patients. Essential Functions: Collaborate to develop and enable a supply strategy that contemplates cost, risk mitigation, supply assurance, quality, and innovation that generates significant enterprise value. Drive the preparation of competitive bids, quotations and proposals with pertinent GMP specifications, terms and conditions and coordinate the introduction of new and modified products and services with appropriate departments. Lead the supplier selection, negotiations, contract implementation, and compliance tracking/reporting. Ensure contract compliance and key performance indicators reporting are established, monitored, and enforced. Identify, build, and maintain mutually beneficial relationships, partnerships, and alliances with select suppliers and business partners through Supplier Relationship lifecycle. Lead financial management with key suppliers and support Finance and Accounting functions for accruals, financial compliance, and budget. Support supplier life-cycle management including identification, selection, on-boarding, and performance management, reviews and approves purchases as authorized, and supports stakeholders and budget owners in negotiating major contracts. Partner with cross-functional leaders to develop, sponsor, and execute external manufacturing process and governance that is effective, and efficient, for enablement of improved supply assurance, risk management, quality performance, cost efficiency, and all other value drivers. Establish relationships with internal business group leaders to provide periodic needs assessments and serve as a thought leader and technical resource. Analyze marketplace research data and make recommendations related to suppliers and supply risks (evaluate and recommend the feasibility of suppliers) - this includes financial as well as business analysis of all suppliers. Understands business objectives and translate those objectives into Procurement priorities Work collaboratively with key business groups in Finance, IT and across the organization to proactively identify process, sourcing, and contract improvement opportunities within Vaxcyte. Development and execution of multi-year category strategies as well as assessing risk of suppliers and materials and recommending risk mitigation plans Continual improvements to performance metrics, programs/processes, and innovations to achieve higher levels of business value. Requirements:&nbsp; Undergraduate Degree required. Advanced degree, diploma or certification in Supply Chain Management, Engineering, or MBA strongly preferred. 15+ years of progressive experience in managing Sourcing or External Manufacturing Procurement processes in biotech, life sciences or a pharmaceutical environment with a minimum of 5 years of experience as a leader of cross-functional teams required. Other combinations of education and/or experience may be considered. Strong organizational, management, teamwork, interpersonal skills, and professionalism required. Driving organizational change and integration activities. Proven experience in delivering measurable process improvements. Financial acumen, experience in creating, managing, and adhering to budgets. Ability to balance, prioritize, and resolve conflicts. Manage multiple projects in a fast-paced environment. Focus on detail with enthusiasm to constantly seek ways to improve processes and practices. Relentless focus and passion around process improvements (efficiency and automation). Excellent communication, customer service and relationship skills are an absolute must. Reports to:&nbsp;Chief Technical Operations Officer &nbsp; Location:&nbsp;&nbsp;San Carlos &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $310,000 - $360,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Executive Director, Technical Operations Strategic Sourcing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for a highly skilled, motivated, and talented contractor to join Vaxcyte’s Vaccine Product Development organization as a Senior Associate Scientist (contract) within Protein Development and Clinical Manufacturing. The contractor will assume an important role of development and executing the key analytical methods to support the measurement of titer, impurities and product quality for in-process intermediates. The successful candidate will support the setup of analytical capabilities within protein process development group, perform the method qualification of in process analytical methods and apply the methods for process characterizations.&nbsp; This position is for a scientific role which will be lab based, and will require excellent scientific judgment, independence, precise and consistent data generation and thorough record keeping. Essential Functions: Assist in setting up instrument capabilities to enable the analytical methods development and qualification for protein process characterization. Perform protein analysis using HPLC (size exclusion, ion exchange, reversed phase, etc), CE-SDS, CE-Lif, PicoGreen and Bradford assay, Capillary Western (Jess and Leo), A280 and SoloVPE. Acquire and interpret data for protein titer, molecule characterization for protein process development studies with precision and accuracy. Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports.&nbsp; Assist in troubleshooting of instrumentation and test results.&nbsp; Able to work well independently and in a team setting on assigned tasks, such as method development and sample testing.&nbsp; Participate in group meetings, present results of work, interpret data, and report results in an accurate manner. Work with lab automation to create high throughput methods leveraging liquid handling and robotic technologies. Work in collaboration with other scientists/SME to design experiments and advance more powerful analytical techniques. Requirements:&nbsp; B.S. in Chemistry, Analytical Chemistry, Biochemistry, or related field with minimum 5 years relevant industry experience; MS with minimum 3 years industry experience in Pharma/Biotech industry required. Strong technical understanding in analytical chemistry. Hands on proficiency and with protein analysis using HPLC, CE-SDS, Western blotting, Spectroscopy, etc. Perform accurate and reliable data analysis and interpretation of experimental results related to process characterization. Ability to think critically and demonstrate troubleshooting and problem-solving skills. Maintain accurate records of experimental procedures, results and conclusion in compliance with regulatory guidelines. Team player, proactive and willing to work in a collaborative team environment. Scientific creativity and curiosity for applying new technologies to complex analytical challenges. Reports to:&nbsp;Staff Scientist, Protein Process Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $118,000 – $138,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist, Protein Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team. The Scientist I, Analytical Development, is responsible for executing analytical testing and contributing to analytical method development activities for biologics/vaccine development programs.&nbsp; This role performs routine and non-routine analytical assays using modern analytical techniques, supports method optimization and troubleshooting efforts, and contributes to continuous improvement initiatives with moderate supervision while partnering effectively with cross-functional teams. The position requires demonstrated hands-on laboratory experience, strong technical execution, and problem-solving skills, with the ability to independently plan and execute assigned work, analyze and interpret data, and escalate and/or drive investigations as needed. This role authors and maintains clear technical documentation, including method protocols, method development summaries, and SOPs, and communicates experimental results and conclusions to internal stakeholders. Essential Functions: Method Development &amp; Troubleshooting Contribute to method development, optimization, and qualification/validation readiness activities. Design and execute experiments to evaluate critical method parameters and define appropriate system suitability and control strategies. Troubleshoot assay and instrument performance issues using a structured approach; interpret data to identify likely root causes, implement corrective actions, and document outcomes and recommendations. Support and/or execute method transfer activities, including protocol preparation, training support, execution at receiving labs, and resolution of transfer issues. Author and revise analytical methods, SOPs, protocols, and technical reports; ensure clear documentation of experimental rationale, results, and conclusions for internal review and stakeholder communication. Team Collaboration Partner effectively with cross-functional teams to define analytical plans, meet project timelines, and deliver high-quality outputs. Communicate experimental progress, data interpretation, and emerging risks clearly; propose mitigation plans and align next steps with stakeholders. Contribute to a compliant, safety-focused, and scientifically rigorous lab culture, model good documentation practices and data integrity expectations. Analytical Testing &amp; Data Generation Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical/biophysical techniques). Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable); identify and troubleshoot common issues. Perform data processing and interpretation; summarize results, trends, and potential risks, and escalate complex findings for review and decision-making. Maintain accurate, timely documentation in laboratory notebooks or electronic systems; contribute to clear technical communications to project and cross-functional stakeholders. Laboratory Operations &amp; Instrumentation Coordinate routine instrument maintenance and service activities; interface with vendors as needed and support timely issue resolution. Ensure laboratory organization, cleanliness, and compliant material labeling/storage practices. Manage inventory of reagents, standards, and consumables; initiate procurement, track critical supplies, and support forecasting to avoid stockouts. Safety &amp; Compliance Follow all Environmental Health &amp; Safety (EHS) policies and laboratory safety practices. Handle chemicals and biological materials safely and in compliance with regulatory requirements. Ensure proper waste disposal and adherence to hazardous material handling procedures. Support audit and inspection readiness activities where applicable. Requirements:&nbsp; PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 1-2 years; MS with 5+ years; BS with 8+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered. Strong hands-on experience with multiple analytical techniques, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, Liquid chromatography, Mass Spectrometry, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, and PCR. Experience independently driving method development or optimization activities preferred. Strong knowledge of analytical chemistry/biochemistry principles with demonstrated application to assay development and control strategies. Proven ability to independently troubleshoot non-routine assay and instrument issues using structured root-cause analysis and data-driven decision making. Proficient in analytical software, data processing workflows, and statistical tools. Strong scientific judgment and attention to detail consistently produces high-quality, inspection-ready documentation. Ability to independently plan and prioritize work, manage multiple projects, and meet timelines with minimal supervision. Clear and effective written and verbal communication; able to summarize complex data, present recommendations, and collaborate across functions. Reports to:&nbsp;Senior Manager, Analytical Development&nbsp; &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Expected Contract Length: 6months &nbsp; Hourly Range:&nbsp;$62.00/hr. - $68.00/hr. (SF Bay Area).&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist I (Contract), Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Associate Director, Process Validation and Risk Management will lead and facilitate commercial process validation and risk management activities across Vaxcyte’s end-to-end manufacturing processes. This role focuses on technical strategy, execution, and cross-functional coordination to support commercial readiness, regulatory compliance, and lifecycle management. The incumbent will provide leadership to ensure the organization is equipped to effectively design, execute, and communicate process validation and risk management strategies to internal stakeholders, external partners, and regulatory agencies. This position will report to the Sr. Director of Process Validation within the Global MSAT organization and will collaborate on overall validation strategy, with primary responsibility for process validation execution and risk management frameworks supporting commercial manufacturing. Essential Functions: Process Validation Leadership Provide strategic and scientific leadership for process validation (PPQ, CPV, lifecycle validation) across commercial programs. Lead and facilitate execution of validation strategies to support technology transfer, site readiness, and product launch. Ensure alignment of validation activities with regulatory expectations and lifecycle management plans. Risk Management Develop and implement risk management frameworks, tools, and processes in collaboration with Quality. Lead cross-functional risk assessments to identify, evaluate, and mitigate operational, technical, and regulatory risks. Monitor and communicate risk trends and key risk indicators to stakeholders. Commercialization &amp; Lifecycle Support Support commercial manufacturing operations by ensuring processes remain in a validated and controlled state. Contribute to lifecycle management activities, including process improvements and continued process verification. Cross-functional Interface Collaborate with Regulatory, CMC, Quality, Supply Chain, Procurement, and Engineering to support commercialization and supply continuity. Partner with internal teams and external CMOs to ensure alignment on validation and risk strategies. Technical Oversight Provide guidance for validation of processes, systems, facilities, and methods within the commercial organization. Support deviation investigations, ensuring timely resolution and sustained compliance. Regulatory Contribute to authoring and reviewing regulatory filings and responses to health authorities. Effectively communicate the scientific and commercial rationale for validation and risk management strategies. Process Validation &amp; Comparability Provide leadership for execution of process validation and comparability activities, ensuring data integrity and compliance. Raw Material &amp; Network Support Provide guidance on raw material qualification strategies to ensure supply reliability. Support validation activities across internal and external manufacturing networks. Communication &amp; Leadership Communicate process validation performance and risk insights to key stakeholders. Build strong working relationships and influence across a matrixed organization. Contribute as a key member of the Global MSAT organization to enable successful commercialization. Travel - 10-30% domestic and international travel required.&nbsp;&nbsp; Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 9+ years of relevant experience for Ph.D., 11+ years for M.S./M.A., or 14+ years for B.S./B.A. Strong experience in biologics/vaccine manufacturing, including: Process validation (PPQ/CPV) MSAT, technical operations, or late-stage development Technology transfer and commercialization Experience in quality risk management (ICH Q9) and regulatory expectations Demonstrated leadership in matrixed or cross-functional team environments Ability to apply deep technical knowledge to develop strategies and drive execution Strong problem-solving, organizational, and strategic planning skills Excellent communication and stakeholder engagement skills Ability to analyze data and align stakeholders with organizational strategy Innovative and entrepreneurial mindset to drive continuous improvement An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry.&nbsp; Reports to: Senior Director, Process Validation Location: San Carlos, CA or North Carolina&nbsp; Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $174,000 – $203,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Process Validation and Risk Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: This is an exciting opportunity to serve as a strategic finance business partner to Vaxcyte’s R&amp;D organization, with a focus on clinical studies. The role will support Clinical Operations and the Immunoassay and Non-Clinical teams, with responsibility for clinical trial and serology financial oversight, while flexing to support broader R&amp;D as business needs evolve. This individual will partner closely with Clinical Operations and Serology on planning, forecasting, accruals, financial reporting, and decision support across multiple development programs. Essential Functions: Lead and provide strategic oversight for clinical outsourcing, partnering with Clinical Operations, Clinical Development, Finance, and Legal to assess the best fit for Vaxcyte’s pipeline and outsourced scope of work. Lead the financial and commercial aspects of the RFP process, vendor selection, and budget management for the Clinical organization Manage clinical trials financial updates and support the annual planning process, including analysis of actuals versus forecast, risk and opportunity assessment, and clear reporting to Finance and business leadership Support contract and budget negotiations, bid evaluations, and vendor recommendations across a range of clinical service providers, including CROs, central laboratories, study supply vendors, oversight vendors, and patient recruitment partners Assist functional and department managers in the procurement process, including reviewing and validating invoices, supporting financial controls, and ensuring accurate visibility into vendor spend Partner with Clinical Operations, Clinical Development, Accounting, Procurement, Legal, and other stakeholders to align operational assumptions, vendor spend, timelines, and financial plans Manage the clinical accrual process, including review of applicable CRO and other clinical ancillary vendor contracts. Collaborate with key stakeholders to gather and analyze relevant information to ensure all accruals are complete, accurately computed, documented, and recorded Support program and project teams in identifying cost-saving opportunities, improving efficiencies, and optimizing the financial performance of clinical programs Implement new forecasting and analytics tools, enabling standardized metrics, scenario modeling, portfolio insights, greater transparency, and strategic decision support with an initial focus on clinical trials and serology Understand and maintain Sarbanes-Oxley (“SOX”) documentation and requirements for assigned area Lead other ad hoc analysis to support business partnering as needs evolve Team Leadership This is an individual contributor role that requires collaboration with Procurement, Clinical Operations, and R&amp;D leadership, as well as the ability to influence stakeholders without direct authority Demonstrate leadership through proactive problem-solving, strong business partnership, and a continuous improvement mindset across financial planning, forecasting, and decision support activities Requirements:&nbsp; BA/BS in life sciences, technical, business, or a related field, advanced degree preferred with a minimum 12 years of progressive experience in biotech/pharma, including meaningful finance, FP&amp;A, clinical outsourcing, CRO, or related business-partnering experience. Other combinations of education and/or experience may be considered Experience supporting Phase I-III clinical trials, including budgeting, forecasting, accruals, outsourcing, and vendor spend management, is required. Vaccines experience preferred Must possess strong analytical ability, a continuous learning mindset, and solid business acumen, including an understanding of business operations in a fast-paced environment Strong negotiations, financial modeling, forecasting, and scenario-analysis skills, with the ability to translate complex operational inputs into clear financial insights and actionable recommendations Prior experience with ERP systems, financial planning tools, BI/analytics platforms, and AI-enabled productivity tools preferred Knowledge of US GAAP, financial reporting, accounting controls, and analytics Strong relationship-building skills with internal and external stakeholders Exceptional project management skills, including the ability to prioritize, balance and manage multiple efforts with strong results/goal orientation Excellent organizational, multi-tasking, listening, facilitation, and communication skills Demonstrated ability to work collaboratively across organizations and utilize resources effectively Outstanding written, verbal, and presentation skills, with the ability to convey strategies and results to a diverse audience Ability to operate effectively in a dynamic, fast-paced environment and flex across functions as business needs evolve Reports to:&nbsp;Senior Director, FP&amp;A &nbsp; Location:&nbsp;San Carlos, CA; Onsite 3 days/week in San Carlos, with flexibility for remote work as needed. &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $226,407 - $264,141 (SF Bay Area). Salary ranges for non-California locations may vary.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Financial Planning & Analysis, R&D

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director, Quality Assurance – Vendor Management is responsible for executing the global vendor quality strategy to ensure compliance, scalability, and inspection readiness across Vaxcyte’s GxP supplier network. This role provides leadership and oversight of vendor qualification, audit, supplier notifications, and performance management programs, ensuring alignment with corporate objectives and regulatory expectations. The Director will serve as a key quality leader, influencing cross-functional stakeholders and external partners, while driving continuous improvement, risk-based decision-making, and operational excellence across the vendor ecosystem. Essential Functions: Strategic Leadership &amp; Program Ownership Own and define the global Vendor Management Quality Program, ensuring scalability to support clinical and commercial operations. Provide end-to-end oversight of vendor qualification, auditing, monitoring, and lifecycle management programs. Establish and drive risk-based frameworks for supplier selection, qualification, and oversight aligned with regulatory expectations. Serve as the QA lead for external partnerships, including CMOs, CROs, and critical service providers. Audit &amp; Inspection Readiness Oversee the global supplier audit program including preparation, scheduling, performance and audit closeout. Ensure inspection readiness across the vendor network and support regulatory inspections as a QA subject matter expert. Review and approve audit strategies, reports, and CAPA effectiveness, ensuring timely closure and systemic improvement. Plan, schedule, and conduct supplier audits (on-site and remote) in support of supplier qualification and ongoing oversight programs. Quality Systems &amp; Governance Provide strategic direction and oversight for Quality Agreements, working closely with the Associate Director, Quality Agreements, who leads day-to-day management and execution. Establish and monitor vendor performance metrics and quality KPIs, reporting trends and risks to executive leadership. Ensure robust processes for supplier change management, deviations, and CAPAs related to vendor activities. Drive continuous improvement initiatives to enhance vendor quality systems, compliance, and efficiency. Cross-Functional Leadership &amp; Influence Act as a strategic partner to Technical Operations, Clinical, Regulatory, and Supply Chain teams. Provide expert guidance on risk management, vendor selection, and mitigation strategies. Influence decision-making at the senior leadership level through data-driven insights and quality risk assessments. Team Leadership &amp; Development Build, lead, and develop a high-performing Vendor Management QA team. Foster a culture of quality excellence, accountability, and continuous improvement. Mentor and develop talent, ensuring organizational capability scales with company growth. External Engagement Serve as the primary QA contact for key vendors and partners. Represent Quality in executive-level vendor governance meetings. Ensure external partners operate in alignment with Vaxcyte’s quality standards and expectations. Requirements:&nbsp; BS/BA in a scientific discipline and minimum 12 years of relevant experience in GxP Quality within the biotech/pharmaceutical industry. Other combinations of education and/or experience may be considered. Extensive experience in vendor management, supplier quality, and audit programs. Deep knowledge of GMPs, FDA regulations, and ICH guidelines. Demonstrated expertise in risk management principles and quality systems. Experience supporting both clinical and commercial-stage products strongly preferred. Proven ability to lead teams and influence cross-functional stakeholders at senior levels. Strong track record of inspection readiness and regulatory interactions. Excellent communication, leadership, and organizational skills. ASQ certification (CQA, CQE) or auditor certification preferred. Reports to: Senior Director, Quality Assurance and Compliance &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $211,000 - $246,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Quality Assurance – Vendor Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Research team uses a broad palette of chromatographic tools to purify diverse vaccine antigens. Applicants must have practical, hands-on experience with multiple chromatographic modalities (not limited to monoclonal antibody/Protein A workflows). Experience should include selection, screening, development, scale-up and characterization of various chromatography techniques. Essential Functions: Execute the following AKTA FPLC chromatography techniques: Immobilized metal affinity chromatography (IMAC) Ion-exchange chromatography (IEX) Hydrophobic interaction chromatography (HIC) Size-exclusion chromatography (SEC) Hydroxyapatite (CHT / HA) Designing chromatography trains to reduce host cell protein, endotoxin and aggregates using complementary modalities. Demonstrated DoE experience for multimodal optimization is a plus. Membrane chromatography for high-throughput contaminant removal or virus/VLP processing and as a scale-friendly polishing/scavenging step. Keep accurate and current records of development experiments and/or project related activities in an electronic laboratory notebook. Present data from experiments to the team and contribute to technical discussions. Work within a team environment and provides support as necessary to further the team’s initiatives. Requirements:&nbsp; BS in Biochemistry, Molecular Biology or a relevant science considered, with minimum of 2 years of relevant industry experience or MS with minimum of 1 year of relevant industry experience. Experience with diverse protein targets, bacterial and eukaryotic recombinant proteins, small/large subunit vaccine antigens, fusion proteins, multimeric complexes, glycoproteins, and VLPs. The role requires demonstrated success with alternative capture/polishing methods and orthogonal cleaning strategies appropriate for potential vaccine antigens. Preferred experience with Cell-free protein synthesis system. Familiarity with automation or high throughput workflows such as (96-well plates) and UNICORN/AKTA software DoE integrations. Experience in process development. Strong interpersonal skills to collaborate well within the team and excellent written and verbal communication skills. Reports to:&nbsp;Scientist II, Research &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $105,000 – $123,000 (SF Bay Area)We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a strategic and execution-focused Senior Manager, Supply Chain Planner to join our Supply Chain &nbsp;Planning Team. This role is responsible for leading end-to-end supply planning across clinical and commercial programs, including demand and supply planning, capacity management, inventory strategy, and scenario analysis. The ideal candidate brings deep experience in biotech supply chains, strong systems and analytical capabilities, and a proven ability to translate complex data into actionable plans. This individual will play a critical role in driving cross-functional alignment, scaling planning processes and systems, and ensuring reliable supply to support Vaxcyte’s growth and commercialization objectives. Essential Functions: Lead end-to-end supply planning processes, including demand, supply, capacity, and inventory planning, ensuring alignment with business objectives Develop integrated production and material plans using OMP Unison Planning System in collaboration with internal functions, CMOs, and suppliers Facilitate monthly demand and supply reviews within the S&amp;OP process to align cross-functional stakeholders and enable informed decision-making Continuously improve planning processes, OMP Unison Planning system capabilities, and SOPs to enhance planning accuracy, efficiency, and scalability Build and maintain complex planning models, ensuring comprehensive system parameters and master data to support OMP and ERP integration Define and execute inventory strategies across raw materials, intermediates, and finished goods to balance service, cost, and expiry risk Lead scenario planning and “what-if” analyses to proactively identify risks and opportunities and implement mitigation strategies Monitor supply performance across CMOs to enable high-quality product delivery per plan Develop, track, and communicate KPIs to provide actionable insights and support data-driven decisions Cultivate strong cross-functional and external partnerships to enable effective planning, communication, and execution Requirements:&nbsp; B.S./B.A. required; advanced degree (MBA, MS, or equivalent) preferred 8+ years of progressive supply chain planning experience in biotechnology, pharmaceuticals, or a related regulated industry Deep expertise in end-to-end supply planning, including demand, supply, capacity planning, and inventory optimization Hands-on experience with advanced planning systems (APS), preferably OMP Unison Planning, including implementation and process design Drive exceptional accuracy, precision, and data integrity across all planning activities, with a clear understanding of the substantial financial impact of supply decisions Proven experience leading S&amp;OP processes and driving cross-functional alignment Strong analytical and data modeling skills; advanced Excel required, experience with planning or visualization tools preferred Experience with external manufacturing networks in a GMP environment Demonstrated ability to lead scenario planning and risk mitigation to ensure continuity of supply Strong leadership and influencing skills, with the ability to align diverse stakeholders and drive execution Excellent communication and executive presentation skills Highly organized, with the ability to manage multiple priorities in a fast-paced, evolving environment Detail-oriented with a continuous improvement mindset and focus on operational excellence Reports to: Senior Director, Supply Planning &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $176,000 - $205,000&nbsp;(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Supply Chain Planner

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking an experienced and dynamic leader to join Vaxcyte as Vice President, Manufacturing Operations &amp; Managing Director for Vaxcyte Switzerland GmbH. This role will lead a high-performing operations organization in Switzerland, supporting late-stage development, commercial readiness, and long-term growth.&nbsp;The role will oversee critical capital projects, scale clinical and commercial supply capabilities, and provide strategic and operational leadership across a network of Contract Manufacturing Organizations (CMOs) in Europe to ensure reliable, compliant product supply.&nbsp;This position is accountable for both strategic and operational leadership of GMP activities. Strategically, the role will evolve the manufacturing network, strengthen key external partnerships, and ensure alignment with corporate objectives. Operationally, it will drive site performance, scale capabilities, and deliver program milestones. The role oversees Engineering &amp; Facilities, Manufacturing, Sourcing, and Supply Chain, with dotted-line leadership for MSAT and Quality Control in Visp. Partnering closely with Process Development, Quality Assurance, and Regulatory, this role will drive facility performance and network execution while developing a deep understanding of program drivers and translating these into actionable plans across internal teams and CMOs.&nbsp;This role is critical to ensure timely, compliant, and uninterrupted supply of Vaxcyte’s therapies. Strong GxP knowledge and deep expertise in biologics manufacturing, engineering, and organizational leadership are required. Essential Functions: Provide leadership, strategic direction, and risk-based oversight to translate corporate strategy into global manufacturing execution. Take strong ownership of site success. Lead and manage the Vaxcyte Switzerland organization, including direct and matrixed reporting structures. Build and develop high-performing teams across Engineering &amp; Facilities, Manufacturing, Sourcing, Supply Chain, MSAT, and Quality Control. Oversee and strategically manage CMO relationships, including participation in Joint Steering Committees (JSCs), ensuring alignment on quality, timelines, and cost. Oversee all CMO activities and commercial supply operations to ensure reliable, compliant delivery aligned with market needs. Lead capital projects, including design, construction, startup, validation, and licensing of manufacturing facilities. Drive facility performance, site master planning, continuous improvement, COGs reduction initiatives to support scalability and long-term growth. Establish and enhance manufacturing engineering and facilities capabilities supporting clinical and commercial supply. Develop and monitor KPIs and dashboards to track performance, risks, and progress across operations. Provide comprehensive performance reporting on the supply network to all relevant stakeholders. Collaborate closely with Process Development, Quality Assurance, Regulatory, and other cross-functional teams to ensure alignment and execution excellence. Coordinate resource planning internally and across CMOs, proactively addressing gaps, constraints, and risks. Serve as escalation point for critical production or supply issues, leading cross-functional response. Develop deep understanding of program priorities and translate into execution plans across internal teams and CMOs. Represent Vaxcyte in external engagements, including governmental and regional stakeholders. Champion operational excellence, continuous improvement, and strong GxP complian Requirements: MS in Science or Engineering with 20+ years of experience, or PhD with 15+ years of experience. &nbsp;15+ years of leadership experience in GMP manufacturing, operations, engineering, or large-scale biologics environments. Other combinations of education and/or experience may be considered. Proven experience leading global manufacturing networks, including CMO oversight. Demonstrated success in facility startup, scale-up, and commercialization. Strong experience in microbial GMP manufacturing; multi-valent complex vaccines experience highly desired. Proven ability to build and lead high-performing, cross-functional teams. Experience establishing strong quality, safety, and continuous improvement cultures. Strong financial acumen, including capital project and budget management. Experience identifying and executing strategic investments. Ability to operate at both strategic and operational levels with strong decision-making skills. Excellent leadership, communication, collaboration, and stakeholder management capabilities. Ability to manage multiple priorities in a fast-paced environment. Reports to: Chief Technical Operations Officer Location: Visp, Switzerland Compensation:&nbsp;The compensation package will be competitive and includes comprehensive benefits and an equity component.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Vice President, Manufacturing Operations & Managing Director

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an opportunity for a Project Manager to manage complex, cross‑functional initiatives focused on IT and Finance Systems implementations, ensuring smooth delivery across planning, requirements, system design, testing, deployment, training, and change management. This leader partners closely with finance teams, operations, IT, and vendors to deliver technology solutions that improve data integrity, operational efficiency, and strategic decision‑making.&nbsp;Reporting into the Associate Director of Project Management, the ideal candidate will bring experience managing cross-functional teams, a deep understanding of financial and system implementation workflows, and the ability to drive clarity, alignment, and execution across diverse stakeholder groups. Essential Functions: Support day-to-day project management activities for ERP implementation, with a focus on Finance, Supply Chain, and Data/Analytics workstreams. Coordinate and manage recurring meetings, including scheduling, agenda preparation, and documentation of meeting minutes and action items Maintain and update key project management artifacts, including the project plan, RAIDD log (Risks, Assumptions, Issues, Dependencies, Decisions), and status tracking tools Prepare and update weekly and monthly project status reports and presentation materials for leadership and stakeholder updates Monitor progress across assigned workstreams, proactively identifying risks, issues, and dependencies, and escalating as appropriate Act as a communication liaison between workstream leads and program leadership to ensure alignment and timely information flow Participate in core team and cross-functional meetings, ensuring accurate roll-up of status, risks, and key decisions to program leadership Requirements:&nbsp; Bachelor’s degree in project management, information technology, or a related field. Master’s degree preferred. Other combinations of education and/or experience may be considered. Minimum 5 years of project management experience in IT system implementations, including work with finance applications. Other combinations of education and/or experience may be considered. Experience in biotechnology, pharmaceuticals, medical devices, or other regulated scientific environments preferred. Experience with change management frameworks. Familiarity with GxP validation practices and documentation. Proven success leading multiple projects in complex, multi‑stakeholder organizations. Experience working with supply chain, finance, and IT teams simultaneously. Strong understanding of financial processes (budgeting, GL, AP/AR, procurement, reporting) and laboratory workflows (sample lifecycle, instrument data, QA/QC, data integrity). Advanced proficiency in Smartsheet, including; Complex project plan development, Automation workflows, portfolio and executive‑level dashboards Demonstrated ability to build dashboards and reporting tools that summarize health, risks, KPIs, and resource status for leadership. High level of organization, analytical thinking, resourcefulness, and problem‑solving. Ability to thrive in dynamic, high‑growth environments with evolving priorities. Excellent verbal and written communication skills, with the ability to engage and influence stakeholders at all levels. Reports to:&nbsp;Associate Director, Project Management &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $148,000 - $173,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Project Manager

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As an Accounting Intern for Vaxcyte, you will work on a project as outlined below: Provide support for financial analysis and accounting activities, including variance analysis, manufacturing accounting, SOX compliance, and preparation of financial statements. Conduct research and benchmarking on finance and accounting tools, including AI-enabled solutions, to identify opportunities for process improvement, automation, and enhanced reporting. Assist with maintaining and updating financial documentation, including process flows, Standard Operating Procedures (SOPs), training materials, and internal controls documentation. Leverage AI an advanced Excel tools to improve data analysis, reporting efficiency, and accuracy while adhering to company policies and controls. The Intern will learn and practice: Core accounting and finance processes in a regulated environment to enhance their skills and knowledge. Apply AI tools responsibly to improve efficiency and decision-making. Effective communication of financial insights to stakeholders across the organization. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Accounting, Finance, Business Administration, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to:&nbsp;External Financial Reporting &amp; Audit Lead &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. &nbsp;Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Accounting

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: This is an exciting opportunity to lead procurement support for clinical development programs, serving as a strategic business partner to the Clinical Operations Department, while maintaining the ability to flex across enterprise-wide procurement priorities as business needs evolve. This role sits within the centralized Procurement function in Finance and serves as the primary procurement business partner to the Clinical organization. The Senior Manager, Indirect Procurement - Clinical will lead and support end-to-end procurement activities for clinical trials—from study start-up through closeout—while also flexing across other indirect spend categories to support broader enterprise needs. This role partners closely with Clinical Operations, Finance, and Legal to ensure timely, compliant, and cost-effective execution of vendor engagements.&nbsp; Procurement owns activities including, but not limited to, the requisition to PO lifecycle, vendor selection support, contracting coordination, spend visibility/controls. Essential Functions: Serve as the primary procurement business partner to Clinical stakeholders, providing guidance and influencing vendor strategy, budgeting, and procurement processes. Own and manage the end-to-end requisition-to-purchase order process, ensuring compliance with procurement policies and timely processing of purchasing requests. Lead the request for proposal process including bid comparison, bid review meetings, recommendation on selection and awarding the service. Provide procurement support across additional indirect spend categories (e.g., professional services, G&amp;A, IT) as business needs evolve. Partner with Finance to support budgeting, forecasting, accruals, and spend tracking for clinical programs. Drive standardization and continuous improvement of procurement processes, templates, and workflows in partnership with Finance and Procurement leadership. Support contract negotiation activities in partnership with Clinical Operations and Legal, contributing procurement expertise to ensure appropriate terms, risk mitigation, and alignment with company policies, while ensuring purchase order readiness and alignment with procurement processes prior to contract execution. Manage multiple concurrent procurement activities across clinical programs and other categories in a fast-paced, evolving environment. Requirements:&nbsp; Bachelor’s Degree in Business Administration or related field, with a minimum of 8+ years of procurement, sourcing, or vendor management experience, including experience supporting clinical trials or clinical services in a biopharmaceutical or CRO environment preferred. Other combinations of education and/or experience may be considered. Experience supporting Phase I–III clinical trials, including large, multi-site studies with significant patient enrollment. Must possess strong analytical ability, and solid business acumen including an understanding of business operations in a fast-paced environment. Ability to work independently, prioritize work, and handle simultaneous assignments under tight deadlines. Experience with procurement and financial systems (e.g., Netsuite, SAP, Coupa, Ariba, Oracle) preferred Advanced knowledge of Excel, PowerPoint and Word are required. Demonstrated ability to work collaboratively across organizations and utilize resources effectively. Excellent verbal and written communication skills. Ability to work in the HQ office 3-5 days a week Reports to:&nbsp;Executive Director, Procurement &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $159,000 - $186,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Indirect Procurement - Clinical

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s IT team is seeking a motivated, forward-thinking Manager, IT Quality &amp; Compliance to support executing and supporting IT Quality, Compliance, and Validation (CSV/CSA) activities across GxP systems. This role partners closely with the Director of IT Quality &amp; Compliance to operationalize the IT QSC (Quality, Security, Compliance) strategy and ensure systems remain compliant, secure, and audit-ready.&nbsp;This is a hands-on role requiring expertise in IT system validation, auditing, vendor management, and compliance operations within a regulated GxP environment. Essential Functions: IT Validation &amp; CSV/CSA Execution Execute Computer Software Assurance (CSA) and Computer System Validation (CSV) activities for GxP systems Support validation lifecycle activities (planning, testing, documentation, release, and change management) Provide ITQA oversight for implementation of GxP systems Support data migration validation (reconciliation, traceability, and verification) Audit &amp; Inspection Readiness Perform internal IT CSV audits to ensure regulatory and procedural compliance Support and execute GxP vendor audits Prepare audit documentation, evidence packages, and formal audit reports Support regulatory inspections and inspection readiness activities Vendor Management &amp; Oversight Conduct vendor qualification and periodic vendor audits Support vendor risk assessments and compliance monitoring Ensure vendors meet GxP, data integrity, and security requirements Periodic Reviews &amp; Compliance Monitoring Perform periodic reviews of GxP systems to maintain validated state Identify compliance gaps and drive remediation Support continuous audit and compliance monitoring programs Investigations &amp; CAPA Management Support IT investigations (deviations, incidents, compliance gaps) Author and manage CAPAs, ensuring timely closure and effectiveness Partner cross-functionally to implement corrective and preventive actions Documentation &amp; SOP Development Author and maintain IT and QA SOPs, policies, and work instructions Ensure alignment with GxP and 21 CFR Part 11 requirements Support continuous improvement of documentation and processes Data Integrity, Cybersecurity &amp; Infrastructure Alignment Support implementation of data integrity controls (ALCOA+) Partner with IT Security to align compliance with cybersecurity controls (access, logging, monitoring) Ensure infrastructure supporting GxP systems is maintained in a secure and compliant state (patching, backup, recovery) Identify and escalate risks related to data integrity, cybersecurity, and infrastructure Training &amp; Cross-Functional Collaboration Support IT Quality &amp; Compliance training initiatives Collaborate across IT, Security, Quality, and business teams Promote a culture of compliance, quality, and audit readiness Requirements: Bachelor’s degree in IT, Quality, Life Sciences, or related field and minimum 5 years of experience in IT Quality, CSV/CSA, or compliance in a GxP environment. Other combinations of education and/or experience may be considered. Hands-on experience with: IT system validation (CSV/CSA) Internal and vendor audits Periodic reviews of GxP systems Vendor management and oversight Data migration validation Experience supporting or working with laboratory (GxP lab) and manufacturing systems (e.g., MES, LIMS, lab instruments) Experience with Veeva, ERP systems, or regulated SaaS platforms Experience supporting or implementing GxP systems from a QA perspective Strong knowledge of GxP, 21 CFR Part 11, and data integrity principles Experience authoring SOPs, validation documentation, CAPAs, and investigations Preferred: Experience in life sciences or biotech environments Experience writing and presenting audit reports and familiarity with risk management frameworks Exposure to QSC (Quality, Security, Compliance) integration and knowledge of data governance and data integrity practices Working knowledge of cybersecurity (access control, data protection, incident response) Exposure to IT security and infrastructure controls (patching, system hardening) Experience using AI tools for research, analysis, and process optimization Reports to:&nbsp;Director, IT Quality &amp; Compliance &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $169,000 - $197,500 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, IT Quality & Compliance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: A hands-on role providing both strategic and operational activities. This role develops and executes multi-product global regulatory CMC strategies for investigational products and leads the preparation and filing of regulatory CMC submissions. Manages interactions with Health Authorities for CMC topics. Provides regulatory CMC guidance to various cross-functional teams and ensures all applicable global regulatory requirements are considered and incorporated into product development. Conducts routine regulatory surveillance and communicates new/changing regulations. &nbsp; Essential Functions: Leads the preparation and review of CMC sections of global regulatory submissions, as well as the interactions and responses with regulatory agencies Member of technical development teams which require experienced interpretation of applicable EMA/FDA/ICH/Global regulations to ensure CMC compliance Defines CMC content (data and documentation) requirements for regulatory submissions and compiles/reviews this content for conformance with established requirements Provides CMC regulatory guidance to cross-functional teams and key stakeholders Manages regulatory assessment and guidance on product compliance topics including change controls, deviations, and GMP investigations throughout development Leads projects with cross-functional teams and acts as the primary regulatory CMC contact for assigned products and projects Represents company in Health Authority meetings and leads or supports CMC preparation activities for meetings with Health Authorities on CMC related matters Stays abreast of current and evolving regulatory CMC requirements, applies this knowledge to assigned projects, and shares knowledge and experience with others to support their development Participates in the design, development and implementation of department strategies, providing recommendations in area of expertise Requirements: Bachelor’s Degree in a scientific discipline (e.g. Biology, Chemistry, Pharmacy, Regulatory Affairs for Drugs, Biologics or Medical Devices). Minimum 10 years of experience working in vaccine or biotech industry, or in a related field, or the equivalent combination of education and experience. Other combinations of education and/or experience may be considered. Prior experience preparing/authoring CMC DS sections: BLA highly preferred. Post-approval supplements/variations highly preferred. INDs/IMPDs. Prior development or manufacturing experience is a plus. Computer software skills (LIMS, SAP, TrackWise, Veeva will be used). Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency. Excellent interpersonal skills to communicate difficult concepts. Strategic thinking and strong problem-solving skills Collaborates and communicates in an open, clear, complete, timely, and consistent manner Strong sense of planning and prioritization, and the ability to work with all levels of management Advanced knowledge in regulatory (FDA, EMA, Health Canada and ICH) guidelines Reports to:&nbsp;Executive Director, CMC Regulatory &nbsp; Location:&nbsp;San Carlos, CA/Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $180,000 - $210,500 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Regulatory CMC

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Manager, QMS Vendor Management &amp; Supplier Notifications to support the effective management of supplier-related quality activities within the Quality Management System (QMS). This role will be responsible for the intake, triage, and coordination of supplier notifications within Veeva QMS, ensuring timely impact assessments and appropriate follow-up actions. The individual will partner cross-functionally to assess risk, drive change controls, and maintain supplier compliance. This role will also contribute to vendor qualification activities, supplier management processes, and may support internal and external audit activities as needed. Essential Functions: Supplier Notification Management Manage the end-to-end lifecycle of supplier notifications within Veeva QMS, including intake, triage, prioritization, and tracking. Perform initial assessments of supplier notifications to determine required actions and level of impact. Assign and coordinate impact assessments with cross-functional stakeholders (e.g., Quality, Regulatory, Manufacturing, Supply Chain). Ensure timely closure of supplier notifications in alignment with internal procedures and regulatory expectations. Maintain visibility of notification status, risks, and trends, escalating issues as appropriate. Impact Assessments &amp; Action Management Facilitate and track impact assessments to evaluate potential effects on product quality, regulatory filings, and supply continuity. Coordinate and manage follow-up actions, including change controls, supplier communications, and documentation updates. Ensure actions are completed in a timely manner and in compliance with QMS requirements. Support risk-based decision making and documentation aligned with GxP expectations. Vendor Management &amp; Qualification Support vendor qualification and requalification activities, including risk assessments and documentation review. Maintain supplier records and ensure compliance with approved supplier lists and quality agreements. Partner with cross-functional teams to ensure suppliers meet Vaxcyte quality and compliance standards. Assist in maintaining supplier performance metrics and supporting supplier oversight activities. Audit Support Participate in internal and external audits, including supplier audits, as needed. Support audit preparation activities and contribute to responses and CAPA development for audit observations. Assist in tracking and closure of audit-related actions. Requirements:&nbsp; BA or BS in a scientific or related field. Minimum of 5 years of experience in Quality Assurance, Supplier Quality, or Vendor Management within the biopharmaceutical, vaccine, or regulated industry. Other combinations of education and/or experience may be considered. Experience working within a Quality Management System (QMS), preferably Veeva QMS. Strong understanding of GxP regulations (GMP, GLP, GCP) and supplier quality requirements. Experience with supplier notifications, change control, and impact assessments preferred. Familiarity with vendor qualification and audit processes. Strong organizational and project management skills with the ability to manage multiple priorities. Excellent communication and cross-functional collaboration skills. Detail-oriented with strong problem-solving and risk assessment capabilities. ASQ certification (CQA, CQE) or auditor certification preferred. Reports to:&nbsp;Senior Director, Global Quality Management Systems and Compliance &nbsp; Location:&nbsp;Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $142,000 – $165,000&nbsp;(SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, QMS Vendor Management & Supplier Notifications

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are&nbsp;seeking&nbsp;a scientifically driven and communicative Medical Science Liaison (MSL) to join our Medical Affairs team.&nbsp;The Medical Science Liaison (MSL) serves as a scientific expert in immunization and&nbsp;pneumococcal&nbsp;disease prevention. This field-based role&nbsp;will serve as a trusted scientific partner to&nbsp;healthcare providers, public health officials, and&nbsp;key opinion leaders (KOLs)&nbsp;to support vaccine education, clinical development, and real-world evidence generation.&nbsp;&nbsp; Depending on experience, the role may be leveled at Senior MSL, offering expanded responsibilities in strategic leadership and mentorship.&nbsp; Essential Functions: Stakeholder Management: Build and maintain scientific relationships with key opinion leaders, clinicians, researchers, and public health stakeholders. Scientific Engagement: Communicate epidemiological, clinical and real-world data regarding pneumococcal disease and Vaxcyte’s candidate vaccine. Evidence Generation Support: Where relevant, support investigator-initiated studies and clinical trial recruitment in vaccine research. Insight Collection and cross-functional collaboration: Gather and share field insights on pneumococcal disease landscape, vaccine data needs, and recommendation scenarios. Education and Engagement: Represent the company at scientific meetings, conferences, and stakeholder events. Compliance: Uphold ethical standards and regulatory guidelines in all field activities.&nbsp; Requirements:&nbsp; Advanced degree (PhD, PharmD, MD, MPH) in life sciences, immunology, or public health&nbsp;preferred. A minimum of 5 years of experience in medical affairs, clinical research, or infectious disease. Strong knowledge of immunology and vaccine development. Excellent communication skills with ability to address scientific and public health audiences. Travel: MSL positions are field-based and require significant travel, which can vary depending on the assigned territory. &nbsp; Ability to travel up to 70% of the time. Other combinations of education and/or experience may be considered.&nbsp; Reports to:&nbsp;Senior Director, Medical Affairs &nbsp; Location:&nbsp;Remote - United States &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $184,000 - $215,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Medical Science Liaison

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a scientifically driven and communicative Senior Medical Science Liaison (Sr. MSL) to join our Medical Affairs team. This field-based role is critical in supporting the scientific exchange around our vaccine pipeline, engaging with healthcare professionals (HCPs), public health experts, and key opinion leaders (KOLs). The Sr. MSL will play a pivotal role in advancing vaccine education, supporting immunization strategies, and informing internal teams with real-world insights. Essential Functions: Advanced Stakeholder Management: Build and maintain peer-to-peer relationships with prominent physicians, researchers, key organizations, and high profile key opinion leaders (KOLs) at academic institutions and clinics. Scientific Engagement: Conduct peer-to-peer discussions with prominent physicians, researchers, and other key opinion leaders (KOLs) regarding unmet medical need, vaccine efficacy, safety, and public health impact. Medical Education: Present clinical data and disease prevention strategies at conferences, advisory boards, and educational forums. Public Health Collaboration: Partner with local and national public health organizations to support immunization campaigns and address vaccine hesitancy. Advisory boards and conferences: Participate in and help organize advisory board meetings with KOLs. Represent Vaxcyte at relevant medical conferences and scientific meetings, engaging in scientific exchange and gathering competitive intelligence. Clinical Trial Support: Support in identification of clinical trial sites and provide scientific input on vaccine-related protocols and investigator-initiated studies. Insight Collection: Gather field intelligence on emerging infectious disease trends, vaccination barriers, and unmet medical needs. Cross-functional collaboration: Work closely with internal teams to update/align scientific messaging and contribute to strategic planning. Compliance: Uphold ethical standards and regulatory guidelines in all field activities. Requirements:&nbsp; Advanced degree (PharmD, PhD, MD, or equivalent) in life sciences, immunology, infectious diseases, or public health&nbsp;preferred. At least 8 years relevant experience in a clinical, research, or industry-related medical role; experience in Medical Affairs preferred. Deep understanding of immunization science, epidemiology, and vaccine development. Exceptional communication, presentation, and interpersonal skills. MSL positions are field-based and require significant travel, which can vary depending on the assigned territory. &nbsp; Other combinations of education and/or experience may be considered.&nbsp; Reports to:&nbsp;Senior Director, Medical Affairs &nbsp; Location:&nbsp;Remote - United States &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $204,000 - $238,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Medical Science Liaison

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Manager, Quality Assurance, External Manufacturing is responsible for overseeing quality activities at contract manufacturing organizations (CMOs), ensuring compliance with cGMP standards, and driving performance through KPIs and continuous improvement initiatives. This role leads batch disposition, reviews critical GMP documentation, supports PPQ activities, and collaborates cross-functionally to resolve complex manufacturing and quality issues. The position requires strong expertise in pharmaceutical quality systems, regulatory requirements, and risk management, along with leadership, problem-solving, and communication skills to support both clinical and commercial operations. Essential Functions: Provide Quality Assurance oversight of Contract Manufacturing Organizations (CMOs). Develop and report metrics and key performance indicators (KPIs) to evaluate CMO performance. Represent Quality Assurance at internal cross-functional meetings and Joint Project Team meetings. Lead polysaccharide batch disposition activities, including review of executed batch records, environmental monitoring data, and quality control results. Review and approve GMP documentation, including master batch records, deviations, risk assessments, change controls, and CAPAs. Drive resolution of quality performance issues in collaboration with contract manufacturers. Support Process Performance Qualification (PPQ) activities. Develop, implement, and maintain quality procedures, policies, and standards. Collaborate with key stakeholders to develop solutions to complex manufacturing and quality issues. Participate in compliance audits and regulatory inspections, as required. Promote a strong quality mindset and a culture of quality excellence across all activities. Requirements:&nbsp; Bachelor’s degree in chemistry, Biology, Pharmacy, Engineering, or a related scientific discipline. Minimum 5 years of experience in managing CMO quality, and quality systems management within the pharmaceutical, biotechnology, or life sciences industry. Other combinations of education and experience may be considered. Experience in batch record review, deviations and Out of Specification (OOS) investigations. Thorough knowledge of cGMP, ICH guidelines, FDA/EMA, Swiss medic regulations, and international pharmaceutical quality standards. Experience applying Quality Risk Management principles. Experience supporting both clinical and commercial products preferred. Strong leadership, management, and process improvement skills. Excellent organizational skills with strong attention to detail. In-depth understanding of biologics manufacturing operations. Proven ability to prioritize multiple assignments in a fast-paced, changing environment. Strong problem-solving abilities, including managing complex investigations and root cause analyses. Excellent written and verbal communication skills, with the ability to clearly present quality topics and risk-based decisions to cross-functional teams. Reports to:&nbsp;Director, Quality Assurance &nbsp; Location:&nbsp;Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $151,000 – $176,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Assurance, External Manufacturing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Veeva Configuration Specialist IT role serves as a techno-functional expert for Vaxcyte’s current and future Veeva applications and related technologies. Working closely with business and managed services partners, this role is responsible for implementing, managing, and maintaining Quality, Regulatory and Clinical Veeva Vault system configurations and other GxP and Non GxP enterprise applications. While technical in nature, this role drives business value by blending technology expertise with business process know-how. This is a hands-on role that reports to the Associate Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters. Essential Functions: Lead requirements gathering, impact assessments, analysis, design, and configuration activities. Customize and configure Veeva Vault applications to meet business requirements. Provide Veeva admin and operational support for issues impacting end-users, system unavailability, data integrity, and manage user account provisioning. Help develop and document business process flows. Create and maintain system-specific IT documentation such as configuration forms, business processes, operating procedures, templates and design standards. Establish and maintain close working relationships with cross functional business partners. Collaborate with stakeholders to understand current business processes and identify areas for improvement and optimization. Work with other IT teams to ensure seamless integration with other systems. Provide project management support for enhancement efforts. Follow GxP change management processes for system configuration changes and platform upgrades. Support periodic reviews and related compliance activities. Coordinate with managed services, business partners and assurance teams to implement planned releases and functional change requests. Requirements:&nbsp; Bachelor’s degree in computer science, information systems, or related field. Minimum 3 years of hands-on configuration experience with any Veeva Vault Platform systems and minimum 7 years of total IT Systems experience. Other combinations of education and/or experience may be considered. Strong understanding of Veeva application suites including Quality (QualityDocs, QMS, Vault Training), RIM and Clinical eTMF. Experience with validated GxP environments including implementation, documentation and change management is a must. Extensive experience as a business systems analyst for Enterprise IT systems. Veeva system administration certification is a plus. As is/to be process mapping and analysis. Solid problem-solving skills and ability to troubleshoot issues including root cause analysis. Excellent verbal and written communication skills, with the ability to effectively communicate complex technical concepts to non-technical stakeholders. Technical writing skills for updating SOPs, WIs, Knowledgebase articles and documenting business processes. Reports to:&nbsp;Associate Director, IT Enterprise Systems &nbsp; Location: San Carlos, CA; Ability to be onsite 2 to 3 days a week. &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $164,000 – $191,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Sr. Veeva Systems Analyst

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an energetic and talented individual to join the Drug Product (DP) Process Development team within the broader Process Development organization. The primary responsibility of the incumbent will be to provide technical and engineering support across DP process development activities, spanning late-stage clinical supply, process characterization, tech transfer, and commercial readiness (PPQ) of Vaxcyte’s lead programs. The role requires close collaboration with internal cross-functional partners (Formulation, Analytical Development, MSAT, Quality) as well as external contract development and manufacturing organizations (CDMOs) supporting Vaxcyte’s fill/finish operations. Due to the high number of Drug Substances (up to 31) within the DP and the aluminum-containing adjuvant system, this is arguably one of the most complex Drug Products in clinical and commercial development today, offering the right candidate an incredible opportunity to make a significant impact on the product, the company, and the industry. The successful candidate will be hands-on, detail-oriented, and comfortable operating in a fast-paced environment with fluid priorities. The role is predominantly lab- and office-based at Vaxcyte’s San Carlos headquarters, with opportunities to contribute to studies executed at both internal and external (CDMO) sites. Essential Functions:&nbsp;• &nbsp; &nbsp;Support the development, characterization, and qualification of robust Drug Product processes for late-stage clinical and commercial manufacturing.• &nbsp; &nbsp;Execute bench- and pilot-scale process development studies using down-scaled models, including compounding/mixing, sterile filtration (filter selection and sizing), fill/finish, hold time, and container/closure evaluations.&nbsp;• &nbsp; &nbsp;Perform in-process sample testing and analysis of DP intermediates and finished product to support process monitoring, process characterization, and release.• &nbsp; &nbsp;Maintain accurate and timely data entry and documentation in Benchling (ELN) in accordance with Good Documentation Practices (GDP), ensuring accuracy, completeness, and compliance with established standards and regulatory requirements.• &nbsp; &nbsp;Analyze experimental and manufacturing data using statistical tools (e.g., JMP), identify trends, and summarize findings in technical reports and presentations.• &nbsp; &nbsp;Perform routine lab upkeep and housekeeping to ensure laboratory cleanliness standards are met and conduct regular inventory monitoring and reconciliation.• &nbsp; &nbsp;Work within a team environment and provide support as necessary to further the team’s initiatives. Requirements:&nbsp;• &nbsp; &nbsp;BS in Chemical Engineering, Biochemistry, or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.• &nbsp; &nbsp;Experience in, or exposure to, early- and/or late-stage clinical fill/finish manufacturing under GMP regulations preferred.• &nbsp; &nbsp;Working knowledge of Drug Product unit operations, such as compounding/mixing, sterile filtration, aseptic fill, and container/closure systems (vials, PFS, cartridges).• &nbsp; &nbsp;Experience supporting technology transfer, scale-up/scale-down, process characterization, or CDMO-based manufacturing activities is preferred.• &nbsp; &nbsp;Familiarity with statistical analysis tools (e.g., JMP, Minitab) is preferred.• &nbsp; &nbsp;Experience using electronic lab notebook (ELN) systems, preferably Benchling, is a plus.• &nbsp; &nbsp;Strong interpersonal and communication skills, both verbal and written, with the ability to work effectively with internal cross-functional teams.• &nbsp; &nbsp;Ability to work independently and collaboratively in a fast-paced, cross-functional environment, managing multiple priorities simultaneously.• &nbsp; &nbsp;Ability to execute, document, and interpret drug product process development and characterization experiments, adhering to scientifically sound practices.• &nbsp; &nbsp;Strong technical writing, data analysis, and communication skills. Reports to: Engineer I, Drug Product Process Development Location: San Carlos, CA Expected Contract Length: 12 months Hourly Range: 51/hr. – 56/hr.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Engineer II (Contract), Drug Product Process Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Scientist II (Contract), Conjugation Development, who will contribute to the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on the synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The successful candidate will apply a strong foundation in analytical chemistry and laboratory techniques to optimize and troubleshoot processes, while also supporting related areas such as analytical development and stability studies. This position requires strong organizational skills, clear communication, and the ability to work in a fast-paced, cross-functional environment. Essential Functions: Perform and optimize multi-step syntheses of protein-polysaccharide conjugates. Purify polysaccharides and conjugates using methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF). Analyze polysaccharides and conjugates using methods such as colorimetric assays, HPLC assays, SEC-MALS, and SDS-PAGE, and contribute to method bridging studies and qualification to ensure robustness and consistency. Maintain accurate, well-organized experimental records and support data verification and analysis to enable process optimization and reproducibility. Assist with troubleshooting of synthesis, purification, and analytical procedures. Track inventory of critical reagents and assist with ordering as needed. Support maintenance of assigned lab instruments, perform general lab duties, and contribute to training new team members. Present experimental results and progress updates at group meetings. Contribute to laboratory protocols, reports, and other documentation supporting process development. Collaborate effectively with team members and contribute to cross-functional activities. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, and size-exclusion chromatography; experience with TFF is desirable. Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE. Hands-on experience with protein conjugation reactions or chemical modification of polysaccharides is desirable. Strong attention to detail, organizational skills, and record-keeping abilities. Effective communication skills, both verbal and written. Ability to work both independently and collaboratively in a fast-paced environment. Enthusiasm for learning new skills and applying them to challenges outside of current expertise. Commitment to integrity, professionalism, and safety in all aspects of work. Reports to: Senior Scientist, Conjugation Development &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Expected Contract Length: 12 Months &nbsp; Hourly Range:&nbsp;$51/hr. - $56/hr.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II (Contract), Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking Senior Associate Scientist (Contract), Conjugation Development, who will support the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on analysis of vendor-supplied materials in a capacity similar to a Quality Control Lab, as well as supporting the Conjugation Development team as needed. This is lab-based, full-time position that requires strict adhesion to protocols and documentation standards. The ideal candidate has strong organizational skills, clear communication, a high level of attention to detail, and experience working in a QC environment. Essential Functions: Conduct analyses of vendor-supplied samples using colorimetric assays, gel electrophoresis, and liquid chromatography while strictly adhering to established SOPs Support lab operations Track shipping details for vendor-supplied samples. Review analytical assay data for adherence to SOPs and accuracy. Maintain organized records of review status of notebook entries and analytical data. Contribute to reports, certificates, and other documentation supporting process development. Collaborate effectively with team members and contribute to cross-functional activities. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 5 years of industry experience, or MS degree with minimum 3 years of industry experience. At least 2 years of experience in an analytical development or quality control role. Prior experience running colorimetric assays is required. Prior experience with HPLC is required. Prior experience with SDS-PAGE is required. Excellent attention to detail, organizational skills, and record-keeping abilities. Ability to work both independently and collaboratively in a fast-paced environment. Commitment to integrity, professionalism, and safety in all aspects of work. Reports to: Scientist II, Conjugation Development&nbsp; &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12 Months &nbsp; Hourly Range:&nbsp;$56/hr.&nbsp; $62/hr.&nbsp;&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.&nbsp; Summary: Vaxcyte is seeking an Associate Scientist II (Contract), Conjugation Development, who will contribute to the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on the synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The successful candidate will apply a strong foundation in analytical chemistry and laboratory techniques to optimize and troubleshoot processes, while also supporting related areas such as analytical development and stability studies. This position requires strong organizational skills, clear communication, and the ability to work in a fast-paced, cross-functional environment. Essential Functions: Perform and optimize multi-step syntheses of protein-polysaccharide conjugates. Purify polysaccharides and conjugates using methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF). Analyze polysaccharides and conjugates using methods such as colorimetric assays, HPLC assays, SEC-MALS, and SDS-PAGE, and contribute to method bridging studies and qualification to ensure robustness and consistency. Maintain accurate, well-organized experimental records and support data verification and analysis to enable process optimization and reproducibility. Assist with troubleshooting of synthesis, purification, and analytical procedures. Track inventory of critical reagents and assist with ordering as needed. Support maintenance of assigned lab instruments, perform general lab duties, and contribute to training new team members. Present experimental results and progress updates at group meetings. Contribute to laboratory protocols, reports, and other documentation supporting process development. Collaborate effectively with team members and contribute to cross-functional activities. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, and size-exclusion chromatography; experience with TFF is desirable. Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE. Hands-on experience with protein conjugation reactions or chemical modification of polysaccharides is desirable. Strong attention to detail, organizational skills, and record-keeping abilities. Effective communication skills, both verbal and written. Ability to work both independently and collaboratively in a fast-paced environment. Enthusiasm for learning new skills and applying them to challenges outside of current expertise. Commitment to integrity, professionalism, and safety in all aspects of work. Reports to:&nbsp;Scientist I, Conjugation Development &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Expected Contract Length: 12 Months &nbsp; Hourly Range:&nbsp;$51/hr. - $56/hr.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Sr. IT Systems Analyst, G&amp;A is responsible for leading the architecture, design, and evolution of G&amp;A platforms, with a strong focus on scalable process design and cross-system integration. This role partners with HR, IT and other G&amp;A teams to implement and support end-to-end business processes, establish architectural standards, and contribute to technology decisions that enable efficiency and growth. The analyst ensures platform reliability, data integrity, and seamless operations while delivering strategic enhancements and managing system releases in alignment with organizational priorities. This is a hands-on role that reports to the Associate Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters. Essential Functions: Serve as an IT point of contact for G&amp;A stakeholders; gather, analyze, and document business needs for processes and systems. Document current-state and future-state processes; translate business needs into functional requirements, and system specifications. Support governance and compliance controls (e.g., SOX ITGC where applicable), including access reviews, role/permission audits, segregation of duties considerations, and evidence documentation. Support recurring reporting cycles and audit requests by ensuring data quality, traceability, and timely delivery of requested information. Drive SDLC standards and best practices for technology delivery (intake, requirements, design, testing, release, and documentation) to improve consistency, quality, and auditability. Facilitate communication between HR, IT, other G&amp;A teams and implementation partners to align on scope, priorities, timelines, and outcomes. Support implementation of new features and releases, including test planning, test script creation, UAT coordination, regression testing, rollout planning, and post-go-live stabilization. Develop and maintain support materials, training content, job aids, and end-user documentation to drive adoption and consistent process execution. Ensure G&amp;A systems are operated in accordance with IT policies and procedures, privacy/security expectations, and applicable regulatory requirements. Manage governance for change management across the responsible G&amp;A ecosystem (e.g., change intake and prioritization, change calendar, risk/impact assessment, approvals/CAB as applicable, communications, and release readiness). Develop and maintain documentation (requirements, process flows, training, end-user guides) and deliver enablement as needed. Requirements:&nbsp; Bachelor’s degree in computer science, information systems, or related field. Minimum 7 years of experience supporting enterprise applications, including HR systems (Workday), contingent workforce management solutions,&nbsp;and other G&amp;A systems. Other combinations of education and/or experience may be considered. Hands-on experience with integrations (e.g., API-based integrations, SFTP/file-based interfaces, data mapping/transformations, monitoring, error handling, and reconciliation). Strong data analysis skills: ability to validate data, reconcile results, and perform basic queries. Strong understanding of SDLC practices and IT controls (ITGC), including security and compliance expectations; experience supporting SOX controls and audit evidence collection. Strong analytical, troubleshooting, and problem-solving skills. Business process mapping experience (current-state/future-state), including documenting end-to-end processes and identifying control points. Ability to translate complex business needs into clear functional requirements and technical-ready specifications. Excellent communication and stakeholder management skills; able to translate between business and technical teams and produce clear documentation. Comfort working in a fast-paced, evolving environment with cross-functional teams. Highly motivated, results-focused, and able to manage multiple priorities with a sense of urgency. Experience working with GxP validated systems, supporting CSA/validation documentation, change control, deviation/CAPA support, and inspection/audit readiness is a plus. Life Sciences industry experience is a plus. Reports to:&nbsp;Associate Director, IT Enterprise Systems &nbsp; Location:&nbsp;San Carlos, CA; Ability to be onsite 2 to 3 days a week. &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $164,000 – $191,000&nbsp;(SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior IT Systems Analyst, G&A

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for a highly skilled, motivated, and creative analytical scientist to join Vaxcyte’s Vaccine Product Development organization as Scientist I (Contract) within Protein Development and Clinical Manufacturing. The Analytical Scientist I will assume a critical role of development and executing the key analytical methods to support the measurement of titer, impurities and product quality for in process intermediates. The successful candidate will support the set up of analytical capabilities within protein process development group, development/optimization and qualification of in process analytical methods and apply the methods for process characterization. This position is for a scientific role which will be mostly lab based, this role will require excellent scientific judgment, independence, rigor and thorough record keeping. Essential Functions: Method Development &amp; Optimization: Establish and optimize analytical methods for biologics, including HPLC (SEC, IEX/AEX), GFP assays, and protein quantification. High-Throughput Automation: Design and implement automated workflows using liquid handling and robotic platforms (e.g., Tecan, Big Tuna) to enable high-throughput sample processing and buffer exchange. Data Analysis &amp; Interpretation: Acquire and interpret complex data sets for lysate activity and protein characterization; provide actionable insights for process development studies. Laboratory Execution: Perform precise sample preparation and plate-based assays with a focus on high accuracy and low %CV. Collaborative Design: Partner with cross-functional SMEs to design experiments, troubleshoot instrumentation, and advance novel analytical techniques. Reporting &amp; Documentation: Maintain rigorous documentation in Electronic Lab Notebooks (ELNs) such as Benchling; present data-driven results at group meetings and contribute to technical reports. Project Ownership: Work independently to manage assigned tasks, from initial method development through to routine sample testing and troubleshooting. Requirements:&nbsp; Education: PhD with 1-2 yrs experience, or B.S in Chemistry, Analytical Chemistry, Biochemistry, or related field with minimum 8 years relevant industry experience; MS with minimum 5 years of industry experience. Technical Proficiency: Extensive hands-on experience with AEX/SEC-HPLC ,&nbsp; GFP assays , and automated platforms like Big Tuna. Analytical Rigor: Demonstrated ability to perform reliable data analysis and interpret results within the context of process characterization and regulatory guidelines. Problem Solving: Strong critical thinking skills with a proven track record of troubleshooting complex instrumentation and assay variations. Soft Skills: A proactive team player with excellent communication skills and the ability to thrive in a fast-paced, collaborative laboratory environment. Innovation: A natural curiosity for applying new technologies and scientific creativity to solve complex analytical challenges. Reports to: Staff Scientist, Downstream Development for Protein Development and Manufacturing &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Expected Contract Length: 12 months&nbsp; &nbsp; Hourly Range:&nbsp;$62/hr.&nbsp; -&nbsp; $68/hr. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist I (Contract), Protein Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Formulation Development team. The Associate Scientist will play a key supporting role in the development of innovative protein–polysaccharide conjugate vaccines. The successful candidate will support formulation development activities to advance Vaxcyte’s drug product pipeline from early development through commercialization. This role will also involve supporting scientists in the execution of experimental studies, as well as the testing and characterization of formulations, supporting investigations, and contributing to process optimization and technical problem-solving. Essential Functions: Support for the manufacture of complex drug product formulations for use in analytical and process development, validation of assays etc. Organize the formulation development lab benches and storage space by setting up weekly cleanup schedules with the team, fridge space management, and maintaining the lab to meet safety standards. Support the scientist in execution of experiments by utilizing biochemical, biophysical and particle techniques, and as well as assisting with data interpretation. Prepare buffers and lab reagents for use in manufacturing and testing activities. Execute experiments with scientific rigor and excellent documentation. This position reports into the Formulation Development line&nbsp;and is part of the broader Process Development and Manufacturing group. Significant partnerships with the Analytical, Device, and Process Engineering teams will occur; thus, the ability to work within this collaborative environment is essential. This role requires agility in both thought processes and practical execution. In addition, being scientifically pro-active within the small group will be encouraged. This is a lab-based position and requires the ability to stand or sit for extended periods as well as work in biosafety cabinets. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 1-2 years of relevant industry experience. Solid understanding of analytical chemistry or biochemistry principles. Experience in calculating buffer recipes and preparing buffers and laboratory reagents is required. Demonstrates highly efficient, organized, and methodical work practices encompassing practical lab tasks, notebook maintenance, and comprehensive record keeping. Prior experience with an Electronic Lab Notebook (ELN) system is preferred. Experience with method troubleshooting and data analysis. Experience with Microsoft Office software (Word, Excel, PowerPoint) is required. An understanding of analytical statistical analysis is also preferred. Familiarity with GraphPad Prism and JMP is also desirable. Attention to detail and excellent skills in pipetting and sample preparation. Demonstrated ability to work collaboratively in a cross-functional team environment on multiple projects. Strong interpersonal skills, with excellent written and verbal communication skills. Reports to: Scientist I, Formulation Development&nbsp; &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12months&nbsp; &nbsp; Hourly Range:&nbsp;$40/hr. - $45/hr.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist I (Contract), Formulation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an exciting opportunity for a highly-motivated and talented individual to join our Formulation Development team. The Senior Research Associate Scientist will play a critical role in the development of innovative protein–polysaccharide conjugate vaccines.The successful candidate will independently design, execute, and support formulation development activities to advance Vaxcyte’s drug product pipeline from early-stage development through clinical studies and commercialization. In this role, the candidate will lead complex experimental studies, including the design of formulation screening strategies, analytical testing, and physicochemical characterization of drug products; support investigations; and contribute to process optimization and technical problem-solving. Essential Functions: Support and execute the manufacture of complex drug products to support formulation development, analytical development, animal immunogenicity studies, and process development. With guidance, design, plan, and independently perform complex experiments, including troubleshooting and optimization of formulation processes. Analyze and interpret experimental data; clearly communicate findings through presentations in working group meetings and contributions to technical reports and presentations. Analyze samples with biochemical, biophysical and particle characterization techniques, interpret results, and communicate conclusions to the broader team. Prepare buffers, solutions, and reagents to support formulation and analytical activities, ensuring accuracy and consistency. Maintain scientific rigor and ensure detailed, accurate documentation of all experiments conducted. Support and enhance laboratory organization, including bench management, inventory control, and compliance with safety and regulatory standards. Ensure accurate, thorough, and timely documentation of all experimental work in electronic lab notebooks. This position reports into the Formulation Development function and is part of the broader Process Development and Manufacturing group. This position will collaborate with cross-functional groups and the ability to work effectively in a collaborative environment is essential. Demonstrate agility in both scientific thinking and practical execution; a proactive, solution-oriented mindset is strongly encouraged. This is a lab-based position and requires the ability to stand or sit for extended periods as well as work in biosafety cabinets. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 5 years of relevant industry experience, or MS degree with minimum 3 years of relevant industry experience. Experience in vaccine formulation development is a plus. Strong hands-on experience in buffer preparation, formulation development, and laboratory techniques. Demonstrated ability to independently design and execute experiments and troubleshoot technical challenges. Proficiency in maintaining detailed and accurate records; experience with electronic lab notebooks (ELN) is required. Experience interpreting complex data sets with data analysis tools (e.g., GraphPad Prism, JMP) and a solid understanding of statistical analysis is preferred. Strong organizational skills with attention to detail in pipetting, sample preparation, and data recording. Proficiency in Microsoft Office (Word, Excel, PowerPoint). Proven ability to work effectively in a cross-functional, collaborative environment across multiple projects. Strong interpersonal, written, and verbal communication skills. Demonstrated initiative, scientific curiosity, and the ability to contribute strategically within a fast-paced team. Reports to: Scientist II, Formulation Development&nbsp; &nbsp; Location: San Carlos, CA&nbsp; &nbsp; Expected Contract Length: 12months&nbsp; &nbsp; Hourly Range:&nbsp;$56/hr.- $62/hr.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist (Contract), Formulation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly skilled and motivated Associate Scientist II (Contract) to join our Analytical Development team to support the characterization of drug substances, protein intermediates, and drug products using LC-MS and complementary analytical techniques The ideal candidate would be central to implementing mass spectrometry-based workflows, interpreting complex data, and collaborating cross-functionally to advance our vaccine programs. Essential Functions:&nbsp; Prepare samples and perform analyses per SOPs, including detailed data interpretation. Independently execute analytical assignments with accuracy and efficiency. Implement LC-MS workflows for proteins, conjugates, and other in-process molecules. Operate, maintain, and troubleshoot Orbitrap, qTOF, and triple quadrupole mass spectrometers. Conduct rigorous data analysis, interpret results, and present findings in team meetings. Partner cross-functionally to develop analytical strategies and support their needs. Maintain accurate documentation in an electronic lab notebook system. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry, Biochemistry, or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience. Hands-on experience utilizing mass spectrometry platforms, including hybrid Orbitraps, qTOFs, and triple quadrupoles. Familiar with peptide mapping, and intact protein analysis workflows. Excellent organizational skills, attention to detail, and documentation expertise. Strong scientific curiosity and problem-solving abilities. Effective communication and collaboration within cross-functional environments. Ability to rapidly learn analytical workflows and technologies. Experience using electronic lab notebook (ELN) systems is a plus Scientific creativity and curiosity for applying new technologies to complex analytical challenges. Reports to: Scientist II, Analytical Development&nbsp; &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12 months&nbsp; &nbsp; Hourly Range:&nbsp;$51/hr. - $56/hr.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

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