Rapport Therapeutics is a biotechnology company focused on developing innovative therapies for a wide range of diseases. With a commitment to advancing healthcare through cutting-edge research and development, Rapport Therapeutics aims to revolutionize the treatment landscape and improve patient outcomes.

Manager/Senior Manager, Regulatory Strategy

Director, Financial Planning & Analysis

Manager/Senior Manager, Clinical Quality Assurance

Senior Manager/Associate Director, Analytical Chemistry

VP/SVP, Clinical Development, CNS

Principal, Neuroscientist

Medical Director, Epilepsy

Director, DMPK & Bioanalytical - Drug Development

Director/Sr. Director, In Vivo Pharmacology

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! Your impact: High visibility role in support of all clinical development programs to ensure potential risks are identified and managed, as well as leading aggregate safety reporting for assigned programs Your day-to-day: &nbsp; You will provide scientific, clinical, and pharmacovigilance expertise along with strategic and operational support for key deliverables and activities in clinical development including: Product Oversight Overseeing aggregate reports production, clinical trial and any post marketing activities, signal management, literature review, and ad hoc regulatory responses for assigned product group Lead product safety surveillance activities for assigned product(s) during all phases of the product lifecycle (includes both investigational and marketed products). Serve as key analytic and safety support lead in close collaboration with the product safety physician/medical monitor. Clinical Trial Support Participate in protocol design, safety CRF development, safety monitoring plan, support of DSMB/DMC activities, coding review as well as SAE reconciliation activities. Review study protocols, statistical analysis plans and other clinical study-related documents Review standard design of tables, figures, and listings for safety data from clinical studies Key safety representation in Integrated Safety Summary reviews, which may include narrative generation, review and approval for filing related activities Manage updates to Investigator Brochure, Company Core Safety Information and other Reference Safety Information. Aggregate Reports, Risk Management Plans, and REMS Activities Demonstrate effective leadership skills with cross functional partners to ensure that safety data analyses/authorship for ad hoc queries and aggregate reports are of high quality and are completed and submitted according to required timelines. Lead PSUR/PADER/DSUR strategy, preparation and adherence to timelines with key stakeholders and vendors. Support RMP updates as appropriate for the assigned product(s). Contribute to the development of Risk Evaluation and Mitigation Strategies (REMS) or REMS amendments. Supports preparation of REMS assessment reports by contributing to the safety-relevant sections. Signal Detection and Management Implement signal detection strategy approved by the Safety Surveillance Team (SST) and Safety Review Committee (SRC). Review adverse event data, literature, and other safety-relevant data for signal detection. Prepare review of potential safety signals for Head of DSPV. Responsible for signaling review and the coordination and documentation of all signal review activities with the product safety physician and product complaint staff. This includes performing signal investigations and drafting signal investigation reports. Coordinate ad hoc safety query or health hazard evaluation response plan for analysis in conjunction with the product safety physician, biostatistics and others as needed, including performing analysis and drafting of query responses for review and finalization. Support in preparing SST/SRC slides and documenting meeting minutes. Procedures and Compliance Ensure PV activities remain compliant with evolving regulations, that respective SOPs and work instructions regarding signaling, ad hoc and aggregate safety and risk management plans are adequate. Assisting in the successful implementation, execution and maintenance of safety processes and systems that conform to the company’s business strategy, industry standards and compliance with global regulations. Keeping updated on relevant regulations associated with the above activities. Contributes to initiatives for process improvement and cross-product process consistency. Facilitate inspection readiness activities, if applicable. Must-Haves: Manager is 6+ years, and Sr. Manager has 8+ years’ experience. Bachelor's degree in Life/Health Sciences Strong familiarity with ICH E6 (R2) Good Clinical Practice requirements and GCP (R3) implementation. Knowledge of Quality Assurance principles, concepts, industry practices, and standards Experience with clinical study platforms including but not limited to – eTMF, EDC, eCOA, IRT, etc. Experience in participating in and overseeing GCP audits; experience including external CRO, clinical/regulatory and document auditing desirable. Experience in all phases of regulatory submissions and interactions; international experience preferred. Require minimal experience with mid/late phase clinical trial organizations. Experience in clinical trials with small molecules Strong communication and the ability to collaborate effectively across the organization. Demonstrated diplomacy, active listening, and a problem-solving mindset to foster a culture of continuous team-based improvement. Hybrid position with 1+ day per week in Boston office Ability to travel to clinical vendors/ clinical study site collaborators (up to 10%) What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $270,000 to $290,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; &nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

Senior Director, Drug Safety and Pharmacovigilance Scientist

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! Your impact: High visibility role in support of the DSPV infrastructure, safety governance, and management of DSPV staff, with oversight of risk management for all clinical development programs Your day-to-day: &nbsp; Oversight of all DSPV activities including SOPs, vendor management, pharmacovigilance agreements, safety governance, risk management, DSPV input to clinical development and clinical study teams, and safety input to regulatory strategy and documentation: DSPV Infrastructure Maintaining DSPV SOPs and templates in compliance with GVP guidance Ensuring that DSPV activities remain compliant with evolving regulations Selecting and overseeing vendors, with appropriate KPI adherence Ensuring Rapport DSPV is future-proofed, particularly the ability to scale process and staff as demands increase and the support of a commercial product approaches Establishing and maintaining pharmacovigilance agreements with partners Ensure clinical study teams (CSTs) are fully staffed by DSPV (operations and safety science) so that appropriate input to clinical study protocols, safety data case report forms, and safety monitoring plans is provided Assisting in the successful implementation, execution and maintenance of safety processes and systems that conform to the company’s business strategy, industry standards and compliance with global regulations Contributing to initiatives for process improvement and cross-product process consistency Facilitating inspection readiness activities across DSPV and with cross-functional partners Safety Governance Overseeing risk management activities for all programs Establishing program-specific safety surveillance teams (SSTs) and appropriate escalations to the safety review committee (SRC) Leading safety surveillance activities and signal management for all programs during all phases of the product lifecycle (including both investigational and marketed products) Ensuring that aligned and accurate safety messaging is incorporated into integrated safety summaries, regulatory documents, aggregate safety reports, and ad hoc regulatory responses Managing updates to reference safety information, including Investigator Brochures and Company Core Safety Information, and coordinating ad hoc safety queries or health hazard evaluations as needed Providing escalation point for the review of potential safety signals across all programs Management of DSPV Function Demonstrating effective leadership skills with cross functional partners to ensure that DSPV input is sought and provided in a timely manner across all programs Ensuring that DSPV is “right sized” with high-quality, skilled and experienced staff to deliver world-class DSPV activities Preparing an appropriate DSPV annual budget Must-Haves: RN, PharmD, NP, MD, MS/PhD, DVM or equivalent Relevant life science background and a minimum of 15+ years of experience in drug safety serving in a PV Scientist or similar role Demonstrated leadership of a DSPV function or large DSPV sub-function&nbsp; Demonstrated leadership skills, with a great reputation for effective cross-functional interactions Demonstrated excellence in managing and mentoring DSPV staff Demonstrated ability to provide strategic safety input to regulatory strategy and clinical development planning Strong organizational, project management and leadership skills Solid knowledge of pharmacovigilance and drug development, including knowledge of applicable clinical trial safety regulations and post-marketing safety regulations, including familiarity with case processing, expedited reporting rules, and safety database concepts Experience working with all levels of management and consulting with key business stakeholders with an ability to influence for greater outcomes Strong team player who has a customer service approach and is solution oriented Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors Possesses strong written and verbal communication skills &nbsp; What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $300,000 to $330,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; &nbsp; &nbsp; &nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

Vice President, Head of Drug Safety and Pharmacovigilance

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!&nbsp; Your Impact: Rapport is seeking a Director or Senior Director of Biostatistics who will have a pivotal role in shaping the design, analysis, and interpretation of clinical trial data for our precision neuromedicine programs. Reporting to the VP of Biometrics, you will collaborate closely with multidisciplinary teams to advance groundbreaking therapies, ensuring statistical rigor and the highest standards of data integrity throughout the drug development process. Your Day-to-Day: Contribute to the design of clinical trials, including writing or reviewing statistical sections of protocols and statistical analysis plans (SAPs). Perform and validate statistical analyses of clinical trial data using SAS and/or R in accordance with regulatory and internal standards. Support the generation of tables, listings, and figures (TLFs) and contribute to the interpretation of results. Collaborate with Clinical and Regulatory teams to provide statistical input to study reports, regulatory submissions, and publications. Participate in the development and review of case report forms (CRFs) and data management plans to ensure accurate data collection aligned with study objectives. Ensure compliance with CDISC standards (SDTM, ADaM) and regulatory guidelines (ICH, FDA, EMA). Assist in the development, validation, and documentation of statistical methodologies and processes. Oversee and manager external CROs and vendors to ensure high-quality and timely deliverables. Participate in cross-functional team meetings, providing statistical support and insights to influence decision-making. Ensure all statistical activities comply with regulatory guidelines and company policies. Assist in the preparation of regulatory documents, including Investigational New Drug (IND) applications and New Drug Applications (NDAs). Contribute to development of internal statistical processes, SOPs, and initiatives Must-Haves: PhD with 10+ years of experience (12+ for Senior Director) OR&nbsp;MS with 12+ years of experience (15+ for Senior Director) in statistics, biostatistics, or a closely related discipline within the pharmaceutical or bio-tech sector. Title and compensation commensurate with experience&nbsp; CNS therapeutic area experience is a plus Skilled in scientific programming including SAS or R, or Python for data analysis, graphing, and simulation Comprehensive knowledge of clinical trial design, advanced statistical analysis methods, and familiarity with regulatory guidelines (FDA, EMA, ICH) Extensive knowledge with CDISC standards (SDTM, ADaM) and industry best practices for data collection, analysis, and reporting Ability to communicate complex statistical concepts clearly to non-statistical audiences. Strong attention to detail, organizational skills, and ability to manage multiple projects in a fast-paced environment. Proven collaboration, leadership, and organizational skills Significant experience with global regulatory agency interactions Experience in resource planning, recruiting, and defining organizational needs with senior leaders &nbsp; What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. &nbsp; &nbsp; Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $235,000 to $255,000 for Director level or $270,000 to $295,000 for Senior Director level. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; &nbsp;&nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

Director/Sr. Director, Biostatistics

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!Reporting to the Head of Data Management, as Senior Manager, Clinical Data Management, you will help lead clinical trials and develop and maintain study-specific documentation, including Data Management Plans, eCRF specifications, CRF Completion Guidelines, Data Validation Guidelines, Data Transfer Specifications, Coding Guidelines, Post Production Database Change Control Documentation, Database Audit and Lock Procedures Your impact: The Senior Manager, Clinical Data Management will help lead clinical trials and provide oversight for outsourced clinical data management activities by working effectively with CRO partners to develop and standardize data handling plans, data transfer specifications, metrics and data review tools. Your day-to-day: Act as Data Management lead on assigned projects Provide CRO oversight and management as needed Review and approve the database design, edit checks, CRF completion guideline, and Data Management Plans drafted by CROs to ensure they are compatible with ensuring CDASH, SDTM and industry standards Work with DB programmers to design (e)CRFs and edit checks in the EDC system Develop test scripts and test data for User Acceptance Testing (UAT) Perform and document database and report UAT Receive, integrate, and reconcile electronic data Perform data review via listings and EDC system, issue and resolve queries Manage queries to ensure data completeness and integrity Review and work with Clinical team on medical coding listings Assist with data listing design for Sponsor data review Perform SAE reconciliation Perform pre-lock and data lock tasks Prepare training materials and user guides for EDC data collection tools Participate in client and team meetings as required Design, generate, and review status metric reports as needed Perform archiving of study databases and related documents Provide input to timelines to ensure timely completion of assigned tasks Provide regular status updates, keeping the team informed of any changes Organize and file study documentation Work with the team to implement technical solutions and resolve issues Additional duties and responsibilities as assigned Must-Haves: Bachelor’s Degree in a scientific or health related field or equivalent and 8+ years of clinical data management experience in biotech or pharma, with experience across EDC platforms, Medidata EDC preferred Experience in a clinical research environment, preferably in biotechnology and focused on Neurology and CNS indications; epilepsy, pain and mood disorders a plus Solid technical skills across data platforms; programming experience preferred leading a trial from a Data Management perspective Previous experience designing clinical trials utilizing CDASH and SDTM standard terminology Proficient in cross collaboration with other related functions such as Biostatistics, Statistical Programming, Clinical Operations and Pharmacovigilance Understanding of FDA and ICH GCP guidelines to ensure appropriate reporting of clinical trial data Proficient with data visualization software/tools Experience in regulatory GCP inspections/audits preferred Ability to manage multiple projects in a fast-paced environment Excellent communication and time management skills &nbsp; What makes Rapport special: &nbsp; Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. Your Compensation We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $165,000 to $185,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; &nbsp; &nbsp; &nbsp;&nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

Senior Manager, Clinical Data Management

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! Your Impact: The Senior Director of Statistical Programming is responsible for providing comprehensive leadership and strategic guidance for all statistical programming activities within Rapport’s clinical development programs. Reporting directly to the Vice President of Biometrics, the Senior Director will play a key role in shaping the strategy and long-term vision for the Biometric group’s capabilities, technology infrastructure, and operational processes. Your Day-to-Day: Lead and manage the Statistical Programming function across all stages of clinical development (Phase I-IV), from protocol development to submission and post-marketing activities. Drive strategic planning and resource allocation for programming activities across studies and programs. Oversee the design, development, validation, and documentation of SAS programs for data analysis, TFL (tables, listings, figures) generation, and CDISC deliverables (SDTM, ADaM). Ensure compliance with industry standards (CDISC, ICH, FDA/EMA guidance) and Rapport SOPs. Provide programming oversight for regulatory submissions (e.g., NDA/BLA/MAA), including eCTD packages, data packages, and reviewer guides. Lead the development and implementation of programming standards, automation tools, and quality control processes. Serve as a subject matter expert for programming strategy, data standards, and regulatory expectations. Collaborate with Biostatistics leadership to ensure integration of statistical and programming workflows. Build and mentor a high-performing programming team; provide coaching, career development, and performance management. Manage outsourcing strategy and oversee deliverables from CROs and external vendors. Contribute to cross-functional initiatives to improve data quality, efficiency, and innovation in clinical development. Must-Haves: Master’s or Bachelor’s degree in Computer Science, Statistics, Mathematics, Life Sciences, or a related field. 12+ years of experience in statistical programming within the biotech/pharmaceutical industry Proven ability to build, lead, and develop high-performing programming teams, with a demonstrated track record of mentoring talent, fostering a collaborative culture, and aligning team objectives with broader organizational goals. Expert-level proficiency in SAS (Base, Macro, STAT, GRAPH) and experience with CDISC standards (SDTM, ADaM). Proven track record of supporting successful regulatory submissions (e.g., NDA, BLA, MAA). In-depth knowledge of clinical trial processes, GCP, regulatory requirements (FDA, EMA), and ICH guidelines. Strong project management skills and ability to manage multiple priorities in a fast-paced environment. Experience managing and developing high-performing teams, both internal and external (CRO/vendor). Excellent interpersonal, communication, and leadership skills. Familiarity with R, Python, or other programming languages is a plus. Experience in Neurology or CSN highly desirable. &nbsp; What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. &nbsp; &nbsp; Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $265,000 to $290,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; &nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

Senior Director, Statistical Programming

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!Your Impact: High visibility role in support of the bipolar disorder clinical development program Your Day-to-Day: As a Senior Medical Director, you will provide clinical leadership and strategic medical input for all clinical deliverables in Rapport’s lead program, RAP-219, related to bipolar disorder including: study design and protocol development activities medical monitoring including site interactions, data cleaning, and safety monitoring management of potential safety issues medical input to regulatory documentation participation in clinical study teams and the clinical development team Driving execution of the assigned clinical program and/or clinical trial in partnership with clinical operations Contributing to the development of regulatory documents in support of regulatory submissions, including the clinical sections of INDs and CTAs, safety reports, responses to regulatory authorities and Ethics Committees/IRBs, and other documents as appropriate Ensuring that scientific rigor and innovation is at the forefront our Rapport’s clinical development strategy and implementation Managing engagements with external organizations, key opinion leaders, and advisors Supporting the Head of Clinical Development by providing medical input into clinical development strategy and protocol reviews Working closely with functional partners (Clinical Operations, Data Management, Biostatistics, Regulatory, Medical Affairs) to ensure an integrated and strategic approach to flawless execution and systematic oversight of study protocols Establishing strong collaborations with study investigators and outside medical experts and representing Rapport during investigator meetings and advisory boards Serving as the medical monitor for assigned studies including design, execution, cleaning, and interpretation of study data Must-Haves: Our ideal candidate has a demonstrated ability to assimilate clinical data, perform thorough analysis and review, make crisp assessments, and communicate effectively both verbally and in writing. MD or equivalent medical degree is required Minimum of 5 years’ experience working in the biotech/pharmaceutical industry in clinical research or drug development or as study investigator Strongly preferred advanced knowledge and clinical training and/or drug development experience in Neuropsychiatry Proven clinical development strategist with hands-on experience of designing, implementing, and conducting clinical trials in psychiatry, Phase 2a – Phase 3 Working knowledge of bipolar disorder is required, with proven ability to interpret, discuss and present efficacy and safety data relating to clinical trial(s) and proven ability to understand and interpret basic and clinical scientific research reports Demonstrated ability to establish effective scientific partnerships with key stakeholders Working knowledge of GCP, clinical trial design, statistics, and regulatory and clinical development processes Experience authoring regulatory documents, specifically exposure to the IND/NDA/BLA approval process Ability to communicate and work both independently and collaboratively with colleagues across disciplines Excellent oral presentation skills Ability to think critically with demonstrable troubleshooting and problem-solving skills Comfortable in a fast-paced small startup environment with minimal direction and able to adjust workload based upon changing priorities Demonstrated ability to work effectively either independently or collaboratively in a cross-functional team environment, as well as with external colleagues. Strong organizational, project management and leadership skills Oversees and mentors less experienced clinical development physicians Experience working with all levels of management and consulting with key business stakeholders with an ability to influence for greater outcomes Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors Possesses strong written and verbal communication skills What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $320,000 to $345,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

Senior Medical Director, Clinical Development, Psychiatry

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! Your impact: In this enterprise leadership role you will lead a cross-functional team to develop the integrated development plan for RAP-314, a foundational program in the company’s pipeline, a program with the potential to improve the lives of millions of patients living with pain and create significant value for RAPP.&nbsp; Your day-to-day: Serve as the single accountable leader for RAP-314 from early-stage development through through Phase 2/3 and registration. Opportunity to shape and lead integrated development plan for RAP-314 from IND through product approval. Define and drive the integrated development strategy, ensuring alignment with target product profile, global regulatory expectations, and corporate goals. Lead program-level decision-making, risk assessment, and scenario planning in coordination with senior leadership. Lead and align cross-functional teams including clinical, regulatory, CMC, biometrics, and medical affairs. Provide innovative and flexible operational solutions and options to the cross functional and development teams; assist in preparing scenarios for creative solutions to operational challenges. Oversee timelines, budgets, and resources across functions to ensure milestones are met. Oversee preparation of key regulatory filings (IND amendments, End-of-Phase 2 meetings, NDA/MAA submissions). Represent the program in regulatory agency meetings alongside clinical and regulatory leads. Present program updates, timelines, risks, and mitigation plans to the executive leadership team, board of directors, and investors. Build strong relationships with key internal stakeholders and external partners (CROs, CDMOs, consultants, etc.). Must-Haves: PhD, PharmD, MD, or equivalent advanced degree in a relevant scientific or clinical field. 15+ years of biotech/pharmaceutical industry experience, with proven leadership in small molecule drug development. Significant experience leading cross-functional programs through early and middle stages of development (Phase 1/2) and toward regulatory approval. Demonstrated success in program leadership roles, particularly startup biotech environments. Strong understanding of regulatory pathways and expectations for small molecule therapeutics. Exceptional interpersonal, communication, and influencing skills. Experience managing complex timelines, budgets, and partner relationships. Familiarity with working across multiple geographies (e.g., US and EU regulatory bodies). Experience managing/mentoring in a highly matrixed environment What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. &nbsp; We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $300,000 to $330,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company. &nbsp; This role is based in Boston, MA. We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; &nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

VP, RAP-314 Program Leader

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).&nbsp; Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies.&nbsp;We are excited about the potential of our lead program, RAP-219. &nbsp;Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! Your impact: &nbsp;As a Clinical Trial Associate, you’ll be a key player in keeping our clinical studies on track—managing the details, supporting the team, and helping bring innovative treatments to patients Your day-to-day:&nbsp;&nbsp; Coordinates and tracks the distribution of clinical documents, including but not limited to protocols, protocol amendments, IBs, ICF's, monitoring visit reports, etc. Supports maintenance of inspection-ready Trial Master File (TMF) according to ICH-GCP and company SOPs Perform quality checks on the study TMF with oversight of study Clinical Operations Lead (COL) Assists in preparing and updating study related documents, e.g. study trackers, clinical trial tools and templates, to track study metrics. May coordinate and track clinical study samples and coordination of the distribution of clinical trial supplies, equipment, and laboratory kits. Review and track vendor invoices against contracts with oversight of study COL Coordinates and tracks central lab samples Coordinates and tracks administrative aspects of contract execution and PO generation Produce and distribute study newsletters Supports collection and updating of clinical trial insurance Supports posting of all agreed clinical trials to publicly available websites Assists with various supportive trial activities, e.g. study team contact list management, review of study plans, review patient-facing materials, coordinate applicable translations, etc. Attend study team and department meetings, assisting with meeting logistics, agenda preparation, meeting minutes, action item tracking, and collating materials for meetings. May support additional ad-hoc activities as agreed with the study COL Must-Haves: Bachelor's degree in life sciences or healthcare related field 2+ years' experience in a clinical research related position Strong computer skills including knowledge of Excel, Word, PowerPoint and Outlook Solid understanding of the responsibilities and needs of other functions in a clinical trial Proven ability to work independently and effectively handle multiple priorities in a fast-paced environment Ability to multitask and flex across projects as priorities and deadlines shift Ability to maintain confidentiality of proprietary information A team player that takes initiative &nbsp; What makes Rapport special: Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. Your perspective matters. Stick your neck out, share your ideas – we work as a team. We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. Leadership that CARES – about you, your growth + development. We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! You get to be YOU! Show up as you are and make every day count. Your Compensation: We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?&nbsp; We tell you about our hiring range now - we expect the hiring range for this role to be $90,000 to $110,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.&nbsp; Hybrid Work Environment: We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection. &nbsp; Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. CCPA disclosure notice can be found here.&nbsp;

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