Dyne Therapeutics is a biotechnology company dedicated to advancing life-changing therapies for patients with serious muscle diseases. Leveraging its expertise in muscle biology, nucleic acid delivery, and gene therapy, Dyne is at the forefront of developing innovative treatments to address unmet medical needs and improve the lives of individuals affected by muscle disorders.

dyne-therapeutics

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The Director, Strategy &amp; Business Operations is a strategic and operational partner to Dyne’s leadership, playing a central role in enabling effective Executive Committee (EC) and Board decision-making. This leader drives the end-to-end process for EC and Board submissions; synthesizes complex, cross-functional insights into decision-ready narratives; and leads high-priority, cross-enterprise initiatives tied to corporate strategy and operational excellence. The ideal candidate is proactive, highly organized, analytically strong, and thrives in a fast-paced, highly visible environment. They combine executive presence with rigorous analysis, clear storytelling, and an ability to orchestrate alignment and execution across R&amp;D, Manufacturing, Commercial, Finance, and G&amp;A teams. This role is based in Waltham, MA without the possibility of being a remote role. Primary Responsibilities Executive &amp; Board Support Partner closely with executive leadership to plan, coordinate, and manage EC and Board agendas and operating rhythms Lead the development and refinement of EC/Board materials (presentations, dashboards, briefing documents, pre-reads) that are clear, concise, and decision-oriented Ensure leadership materials consistently highlight tradeoffs, risks, scenarios, dependencies, and recommendations Collaborate with HR and other stakeholders on leadership meeting design, cadence, and execution Prepare high-quality briefing materials, presentations, and reports for the CEO and executive team Analytics, Insights &amp; Enterprise Performance Synthesize complex, cross-functional data into executive-level insights, visualizations, and storylines that enable strategic choices and accountability Develop integrated views of performance, progress, risks, and dependencies using data from multiple functions; ensure consistency, accuracy, and relevance Elevate the use of analytics in EC/Board discussions by framing metrics in context (benchmarks, trends, thresholds) and proposing clear actions Strategic Initiatives &amp; Cross-Functional Leadership Lead enterprise-wide, high-priority initiatives that advance corporate strategy and operational priorities Establish project plans, milestones, owners, and success metrics; drive execution and accountability across teams Use data and insights to track progress, identify risks, and recommend course corrections; escalate issues with solutions Lead special initiatives requiring senior leadership engagement and cross-functional coordination Process Excellence &amp; Operating Rhythm Optimization Own and continuously improve the end-to-end process for EC and Board submissions (timelines, templates, standards, content expectations) Drive consistency and quality across leadership materials, including analytical rigor, visual clarity, and narrative coherence Identify and implement opportunities to streamline decision processes, operating rhythms, and cross-functional workflows to enhance organizational effectiveness Stakeholder Engagement &amp; Executive Communications Serve as a trusted liaison between executive leadership and functional teams to ensure alignment, transparency, and timely decision-making Foster strong relationships with internal stakeholders and Board members Draft and refine executive-level presentations and correspondence; support leaders with data-backed storytelling for leadership forums and internal communications Qualifications Bachelor’s degree required; advanced degree (MBA, MS) preferred or equivalent practical experience 10+ years of relevant experience in Strategy &amp; Operations, Corporate Strategy, Management Consulting, PMO/Transformation, or related roles; experience supporting executive/Board governance strongly preferred Demonstrated ability to translate complex, cross-functional data into executive-ready insights, scenarios, and recommendations; strong quantitative and qualitative problem-solving skills Exceptional written and verbal communication skills with a track record of producing concise, compelling leadership materials Proven ability to lead enterprise initiatives, influence without authority, and drive accountability across diverse teams Experience designing and improving operating rhythms, governance processes, and submission standards Advanced proficiency with Microsoft PowerPoint and Excel. Familiarity with dashboarding/visualization tools (e.g., Power BI, Tableau) is a plus MA Pay Range$196,000&mdash;$240,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Director, Business Strategy & Operations

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The&nbsp;Program Team Leader (PTL)&nbsp;is a passionate, globally minded drug developer who brings adaptable leadership, deep strategic product development&nbsp;expertise, and a relentless commitment to delivering transformative medicines to patients. As a highly visible leader, the PTL partners closely with an experienced Program Manager and a&nbsp;cross functional&nbsp;team to shape Program strategy, define goals and priorities, and chart an integrated plan that balances a&nbsp;future&nbsp;focused&nbsp;vision of global commercial access with the pragmatic&nbsp;decision-making&nbsp;needed to advance through complex development milestones.&nbsp; This&nbsp;role&nbsp;is&nbsp;based&nbsp;in&nbsp;Waltham,&nbsp;MA&nbsp;without&nbsp;the&nbsp;possibility&nbsp;of&nbsp;being&nbsp;a&nbsp;remote&nbsp;role.&nbsp; Primary&nbsp;Responsibilities&nbsp;Include:&nbsp; Program Leadership &amp; Strategy&nbsp; Lead a&nbsp;high-performing,&nbsp;cross-functional&nbsp;Program Team by defining both the&nbsp;what&nbsp;(strategy, priorities, deliverables, and resources) and the&nbsp;how&nbsp;(a healthy, collaborative, and sustainable team environment).&nbsp; Establish, communicate, and continually evolve a robust Program strategy to deliver&nbsp;a life-changing&nbsp;medicine to patients in need.&nbsp; Ensure alignment of research, nonclinical, clinical, regulatory, CMC, and commercial strategies with the overarching Program strategy.&nbsp; Serve as the primary owner of Program recommendations across all stages of development, driving toward milestones, timelines, and&nbsp;value-creating decision points. Decision-Making &amp; Communication&nbsp; Structure,&nbsp;facilitate, and drive&nbsp;timely, high-quality cross-functional&nbsp;decision-making&nbsp;with both the Program Team and senior leadership, ensuring all critical perspectives are appropriately considered.&nbsp; Prepare and deliver&nbsp;high-impact&nbsp;materials for the Board of Directors, Scientific Advisory Board, and other key governance bodies.&nbsp; Maintain clear, open, and proactive communication with senior leadership regarding Program strategy, progress, risks, dependencies, and resource needs. Scientific &amp; External Engagement&nbsp; Stay abreast of emerging scientific and development trends in muscle diseases and oligonucleotide drug discovery and development.&nbsp; Build a visible, credible presence within the KOL and patient advocacy communities for the relevant disease areas.&nbsp; Participate in business development activities as needed, including opportunity evaluations and due diligence. Organizational Leadership&nbsp; Model and reinforce company values, especially during periods of rapid growth and change.&nbsp; Serve as a primary advocate for the Program within the broader portfolio and corporate strategic context.&nbsp; Collaborate with&nbsp;Finance and functional leaders to responsibly manage the Program budget.&nbsp; Foster a culture of scientific excellence, innovation, open communication, and continuous improvement.&nbsp; Actively coach and support team members to help them perform at their&nbsp;best, and&nbsp;identify or mitigate skill or capacity gaps within the team.&nbsp; Consider&nbsp;needs&nbsp;of&nbsp;the&nbsp;Program&nbsp;in&nbsp;context&nbsp;of&nbsp;Dyne&nbsp;corporate&nbsp;strategy&nbsp;and&nbsp;priorities,&nbsp;as primary advocate for the Program among Dyne senior leadership&nbsp; Education and Skills Requirements Experience in Phase 1-3 drug development is required; product launch/early commercialization experience a strong plus Proven and respected leader with: Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent 20 years of experience in pharmaceutical industry in leadership positions in drug development and proven track record in driving Programs through IND, early clinical, pivotal stages and approval And/or at least 12 years in pharmaceutical industry in significant development and/or commercial leadership or general management positions including working with development teams in cross-functional setting, with exceptional track record of delivering on business objectives, activity/milestones leading to filing and launching, and strong knowledge of neuromuscular diseases Experience in rare genetic diseases preferred Other key traits: Entrepreneurial team leader, able to shape and communicate the vision for an important therapeutic Program and guiding the development of the product strategy and its execution Insightful people leader supporting and coaching high-caliber functional experts to achieve their absolute best Collaborative corporate leader partnering with other senior leaders to shape and fulfil Dyne’s overall mission to develop and commercialize transformational therapeutics for people living with serious diseases Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product Adept at leading through ambiguity and provide steadiness and consistency among shifting priorities Comfortable with fast-paced and nimble organizational environment Demonstrated experience in building highly effective and motivated cross-functional teams and in guiding teams and organizations in making complex and high-stakes data-driven decisions Proven acumen for cross-functional leadership and influencing without direct authority, both among cross-functional team members and senior functional leaders Demonstrated scientific knowledge and curiosity necessary for thought partnership across all functions Proven ability to establish and maintain credible and trust-based relationships with external stakeholders (e.g., KOLs, patient advocacy groups, regulators or investors) Outstanding sense of urgency and ability to pace the team’s work to achieve milestone achievement in highly competitive landscape Excellent communication skills (verbal, written, presentation) and ability to clearly communicate complex ideas stakeholders and teams at all levels Natural focus on team dynamics and proven ability to coach and support team members to perform at their best Effective people-oriented collaboration skills in an environment with cross internal functional teams, and third-party collaborators/vendors Team player and mentor, who listens effectively and invites response and discussion Collaborator who communicates in an open, clear, complete, timely and consistent manner MA Pay Range$288,000&mdash;$350,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

VP, Program Team Leader

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The Associate Director, Trial&nbsp;Master&nbsp;File (TMF) Lead&nbsp;is responsible for&nbsp;developing and driving the global TMF strategy,&nbsp;establishing&nbsp;and maintaining robust governance frameworks, and ensuring end&nbsp;to&nbsp;end oversight of the Trial Master File across the clinical portfolio. This role serves as the enterprise owner of TMF processes, quality standards, and inspection readiness, ensuring that TMF operations meet regulatory requirements, support high&nbsp;quality clinical execution, and&nbsp;operate&nbsp;efficiently at scale.&nbsp;This&nbsp;role&nbsp;partners closely with Clinical Operations, Quality, Regulatory, and external vendors to ensure a unified, proactive approach to TMF health, completeness, and compliance&nbsp;&nbsp;Primary Responsibilities&nbsp;Include:&nbsp; TMF Strategy &amp; Leadership:&nbsp; Define and own the company’s TMF strategy,&nbsp;including&nbsp;innovation opportunities and continuous improvement initiatives&nbsp; Lead the development and implementation of scalable TMF operating models, ensuring alignment with clinical development goals&nbsp; Serve as the internal subject matter expert on TMF best practices, regulations, and inspection trends&nbsp; Represent TMF leadership in cross&nbsp;functional forums, governance committees, and senior&nbsp;level operational discussions&nbsp; Governance &amp; Process Ownership:&nbsp; Establish and maintain TMF governance frameworks, including policies, SOPs, work instructions, and quality standards&nbsp; Oversee TMF lifecycle management—from planning and setup through&nbsp;closeout&nbsp;and archival&nbsp; Define TMF roles, responsibilities, and RACI structures across internal teams and vendors&nbsp; Monitor adherence to processes and drive corrective and preventive actions (CAPAs) related to TMF quality issues&nbsp; Ensure&nbsp;timely&nbsp;collection, review, and management of TMF documents from&nbsp;clinical&nbsp;study teams and external partners&nbsp;&nbsp; TMF Oversight &amp; Compliance:&nbsp; Provide strategic oversight of TMF operations, including ongoing quality reviews, completeness assessments, and key performance indicators (KPIs)&nbsp; Ensure TMFs across the portfolio remain inspection&nbsp;ready&nbsp;&nbsp; Lead TMF&nbsp;related preparation for audits, inspections, and regulatory submissions, ensuring all documentation is complete and&nbsp;accurate&nbsp;&nbsp; Analyze TMF metrics and trends to proactively&nbsp;identify&nbsp;risks, gaps, and improvement opportunities&nbsp;to implement proactively&nbsp; Vendor &amp; Technology Management:&nbsp; Oversee TMF service providers, CRO partners, and technology platforms to ensure alignment with TMF requirements&nbsp; Partner with IT and business stakeholders to&nbsp;optimize&nbsp;the eTMF system, workflows, and integrations&nbsp; Ensure vendors adhere to contractual obligations, performance expectations, and quality standards related to TMF&nbsp; Stay up to date with industry trends and regulatory requirements related to TMF management and documentation practices&nbsp;&nbsp; Cross&nbsp;Functional Partnership &amp; Support:&nbsp; Collaborate with&nbsp;cross-functional study teams&nbsp;to guide TMF planning, milestones, and document management expectations&nbsp; Provide training, coaching, and strategic direction to internal and external partners on TMF processes and regulatory requirements&nbsp; Advise&nbsp;leadership on TMF health and organizational readiness for key regulatory events&nbsp; Education and Skills Requirements:&nbsp; Bachelor’s degree in life sciences or related field; advanced degree preferred&nbsp; 8+ years of experience in clinical operations, document management, or related&nbsp;GxP&nbsp;environment, with significant TMF&nbsp;expertise&nbsp; Strong knowledge of&nbsp;ICHGCP, TMF Reference Model, and global regulatory expectations&nbsp; Proven experience developing TMF strategy, governance frameworks, or enterprise&nbsp;level processes&nbsp; Ability to lead cross-functionally without authority&nbsp;Demonstrated leadership in managing TMF operations or oversight at a portfolio level&nbsp; Experience working with eTMF systems and CRO/vendor oversight&nbsp; Excellent communication, influencing, and stakeholder&nbsp;management skills&nbsp; MA Pay Range$155,000&mdash;$190,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Associate Director, Trial Master File Lead

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary&nbsp; The Director, US Field Effectiveness &amp; Operations is a critical role within the Commercial organization, responsible for driving strategic initiatives and operational excellence to fuel business growth. This individual will build the operational infrastructure for the Key Account Manager (KAM) field force from the ground up, including field analytics and dashboards, territory sizing and alignment, targeting, and the development and execution of field force effectiveness programs. This role requires strong cross-functional collaboration across Sales, Marketing, Market Access, Advanced Analytics, Patient Services, Finance, IT, and US Commercial Leadership to ensure launch readiness. The Director will champion innovation and operational efficiency, building scalable processes that enhance collaboration and field productivity with a patient-first mindset. This is a remote-based, individual contributor role requiring strong communication, self-initiative, and consultative engagement skills. Primary Responsibilities Field Effectiveness Build field reporting and analytics capabilities from the ground up to support KAM performance and decision-making. Partner with field leadership to define KPIs and develop analytics and dashboards to track performance and impact. Design and lead a Quarterly Business Review (QBR) process to assess commercial effectiveness and outcomes. Spend time in the field to understand Dyne’s operating model and translate insights into practical, field-ready solutions. Own KAM performance analytics and execution in support of incentive compensation programs. Collaborate with the KAM team to design and implement an account planning tool. Develop regional and account-level performance dashboards. Recommend and drive enhancements to BI and CRM tools to improve KAM effectiveness. Field Operations Serve as the primary point of contact for the VP, Customer Experience, KAM leadership, and the KAM field team. Lead field force sizing and structural planning for upcoming launches and ongoing strategic reviews. Establish and maintain territory alignment and adjustment processes. Lead account and HCP targeting strategy and analytics in partnership with the Data and Advanced Analytics teams. Optimize field enablement tools, materials, and processes to maximize field productivity. Education and Skills Requirements Bachelor’s degree with 10+ years of experience in biotech, pharma, or life sciences. 5+ years of experience in field sales, sales leadership, field operations, or consulting roles with deep field operations exposure. Proven track record supporting or launching rare disease therapies, preferably in neuromuscular, neurodegenerative, or neurodevelopmental indications. Demonstrated ability to build and scale commercial infrastructure, including vendor management. Strategic thinker with strong business acumen and a results-oriented mindset. Proficiency with commercial technology platforms and data, including CRM, BI tools, Snowflake, Boomi, SP/SIP, and HUB data. Excellent written and verbal communication skills, with experience presenting to senior leadership. Strong problem-solving skills and ability to operate effectively in a fast-paced, evolving environment. Travel may be required for this role MA Pay Range$188,000&mdash;$230,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Director, US Field Effectiveness & Operations

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The Senior Manager, Statistical Programming&nbsp;serves&nbsp;as the statistical programming lead for a defined number of clinical studies, with accountability for all study-level statistical programming activities conducted in-house and/or through vendor oversight. This&nbsp;role&nbsp;is&nbsp;the primary point of contact for statistical programming and data standards for assigned studies, providing technical leadership and consultation to cross-functional program teams. The Senior Manager&nbsp;also supports&nbsp;the planning and resourcing of statistical programming activities to ensure&nbsp;timely&nbsp;and high-quality delivery across the Dyne clinical portfolio. This position&nbsp;contributes to departmental strategy, as well as the development and continuous improvement of programming procedures, training, and standards.&nbsp; This is a full-time position based&nbsp;in Waltham, MA.&nbsp;&nbsp; &nbsp;Primary Responsibilities&nbsp;Include:&nbsp; Lead&nbsp;statistical programming for&nbsp;assigned clinical studies, with end-to-end accountability for study-level programming deliverables, quality, timelines, and compliance with regulatory requirements and internal standards&nbsp; Oversee and coordinate FSP vendor-based statistical programming resources, including task assignments, progress tracking, issue escalation, and quality oversight&nbsp; Plan, manage, and&nbsp;monitor&nbsp;project timelines and deliverables across assigned studies to ensure on-time and high-quality execution in alignment with study milestones&nbsp;and escalate risks as appropriate&nbsp;&nbsp; Collaborate closely with biostatisticians, data managers, and cross-functional teams to define and execute effective programming activities and study-specific requirements&nbsp; Develop,&nbsp;validate, and&nbsp;maintain&nbsp;analysis datasets (CDISC-compliant SDTM and&nbsp;ADaM), as well as tables, listings, and figures (TLFs),&nbsp;in accordance with&nbsp;regulatory guidelines and internal standards&nbsp; Review and provide input on Statistical Analysis Plans (SAPs) to ensure programming assumptions, derivations, and outputs are clearly defined and executable&nbsp; Perform or oversee complex statistical programming and analyses using SAS to support clinical trial analyses and data interpretation&nbsp; Provide statistical programming&nbsp;expertise&nbsp;to oversee and/or perform activities supporting regulatory submissions (e.g., FDA, EMA), including the preparation of electronic submission components (eCTD), Define.xml, and reviewer guides&nbsp; Stay current with industry trends, best practices, and emerging technologies in statistical programming, data standards, and regulatory expectations&nbsp; &nbsp; Education, Experience,&nbsp;and Skills Requirements:&nbsp; Bachelor's or advanced degree in statistics, biostatistics, computer science, or a related field&nbsp; 7+&nbsp;years of experience in statistical programming within the pharmaceutical or biotech industry&nbsp; Proficiency&nbsp;in SAS is essential; experience with R is preferrable&nbsp; Strong knowledge of CDISC standards (SDTM,&nbsp;ADaM) and regulatory requirements for clinical trials&nbsp; Demonstrated leadership and project management skills, including the ability to collaborate with cross-functional teams&nbsp; Excellent&nbsp;written and verbal&nbsp;communication and interpersonal skills&nbsp; Detail-oriented with a commitment to data accuracy and quality&nbsp; Ability to adapt to changing priorities and manage multiple projects simultaneously&nbsp; MA Pay Range$143,000&mdash;$175,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Senior Manager, Statistical Programming

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The Director, Business &amp; Operations – US Affiliate will serve as a key strategic and operational partner to the SVP, Head of US Affiliate, supporting the effectiveness, execution, and scalability of the US Affiliate organization. This role will provide operational leadership and continuity across the function, enabling the SVP and US Affiliate Leadership Team to remain focused on the highest‑impact priorities as Dyne builds and grows its US presence. The Director will be responsible for business operations across the US Affiliate, including budget ownership and financial planning, vendor and contract management, operating rhythm and governance, and the execution of function‑wide initiatives. Acting as a connective hub across Commercial, Medical, Finance, Legal, HR, and other G&amp;A partners, this leader will translate strategic priorities into well‑structured plans, drive execution, and ensure visibility into progress, risks, and resource needs. The ideal candidate is highly organized, proactive, and comfortable operating in a fast‑paced, evolving environment. They bring strong judgment, executive presence, and the ability to influence without authority, paired with a hands‑on approach to getting work done. This role is based in Waltham, MA. Key Responsibilities Strategic &amp; Operational Partnership Serve as a trusted thought partner to the SVP, Head of US Affiliate, helping translate affiliate strategy and priorities into clear, actionable, and measurable operating plans. Support the US Affiliate Leadership Team with structured problem solving, prioritization, and follow‑through across key initiatives. Anticipate organizational needs and proactively bring recommendations, options, and solutions to leadership. Business Operations &amp; Operating Rhythm Establish and manage the operating rhythm for the US Affiliate, including leadership meetings, business reviews, planning cycles, and governance forums. Drive clarity on goals, ownership, timelines, and success metrics across affiliate initiatives. Develop and maintain dashboards and tracking tools that provide transparency into performance, risks, dependencies, and decision points. Budget, Financial Planning &amp; Resource Management Support development and management of the US Affiliate budget in close partnership with Finance, including annual planning, forecasting, tracking, and variance management. Support headcount planning, resource allocation, and investment prioritization to ensure alignment with affiliate and enterprise objectives. Prepare budget materials, analyses, and recommendations for affiliate leadership and enterprise review forums. Vendor, Contract &amp; External Partner Management Oversee vendor strategy and management for the US Affiliate, including agency partners, consultants, and other external service providers. Partner with Legal, Finance, and Procurement to manage contracts, statements of work, renewals, and compliance. Ensure vendors are delivering against scope, timelines, and value expectations. Cross‑Functional &amp; Enterprise Initiatives Lead and coordinate high‑priority, function‑wide and cross‑functional initiatives impacting the US Affiliate. Act as a central point of integration between the US Affiliate and partner functions to ensure alignment and execution. Track initiative progress, identify risks, and escalate issues with proposed solutions. Leadership Enablement &amp; Execution Drive coordination across HQ and field‑based roles spanning Commercial, Medical, and partner functions to maintain momentum and alignment on priority initiatives. Design and manage the US Affiliate “Cadence of the Business,” including Leadership Team meetings, offsites, business reviews, and short‑ and long‑term planning cycles. Serve as a leader for high‑priority initiatives that do not have a natural functional home (e.g., ways of working, launch KPI management, executive reporting). Support change management and organization‑wide communication for new processes, initiatives, and ways of working. Qualifications &amp; Experience Bachelor’s degree required; advanced degree (MBA or equivalent) preferred. 10+ years of progressive experience in commercialization strategy, commercial operations, program management, or related roles within biotechnology or pharmaceuticals, or relevant experience from a biotech or life sciences consulting firm focused on commercialization or commercial planning. Experience supporting senior leaders and leadership teams in high‑growth or launch‑stage environments. Demonstrated experience with budget management, financial planning, and vendor/contract oversight. Strong cross‑functional leadership skills with the ability to influence without formal authority. Exceptional written and verbal communication skills; able to synthesize complexity into clear, executive‑ready thinking. Highly organized, detail‑oriented, and comfortable managing multiple priorities simultaneously. High integrity and discretion in handling sensitive and confidential information. MA Pay Range$188,000&mdash;$240,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Director, Business & Operations – US Affiliate

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: Dyne Therapeutics is seeking an experienced Data, Integration and AI Engineering lead to direct, manage, and optimize the strategy, architecture, and delivery of the company’s enterprise data, integration, and AI technology ecosystem. The ideal candidate will have deep expertise in integration architecture, hands-on experience with the stand-up and operation of Boomi and Snowflake, and a strong background in biotech or pharmaceutical environments where compliance and data integrity are paramount. This role is accountable for: Enterprise data architecture Integration architecture and platform strategy Applicable Cloud-native AWS architecture Dyne’s Snowflake data platform Boomi (or equivalent) integration platform Design and build-out of an AI Technology Foundry The Director will establish scalable, compliant, and secure architectures that support Dyne’s clinical, commercial, research, and corporate functions, while enabling advanced analytics and AI-driven capabilities. This leader will work cross-functionally with our Managed Service Provider, Omnichannel Digital Marketing Team, IT, Clinical, Commercial Operations, Finance, and external partners in a highly regulated biotech environment. This role is based in Waltham, MA.&nbsp;&nbsp;Primary Responsibilities Include:&nbsp; Enterprise Data &amp; Integration Architecture Leadership Own and define enterprise data architecture and integration architecture standards across Dyne. Serve as the architectural authority for system-to-system integrations, data flows, APIs, and event-based architectures. Design scalable patterns for integrating internal platforms and external partners, including: 3PLs Specialty pharmacies CROs Data aggregators Commercial, clinical, and regulatory systems Ensure architectural alignment across ERP, CRM, HRIS, Channel, and analytics platforms. Establish architectural principles that support “build once, scale across products and geographies.” Integration Ownership &amp; Development: Provide executive oversight of the integration approach, tools and platforms Serve as the primary owner of the Boomi integration platform and Snowflake data lake environment. Design, build, and deploy integrations between internal systems and external partners (e.g., 3PL, specialty pharmacy, CROs, data aggregators). Develop and maintain integration workflows, connectors, APIs, and ETL/ELT processes for data ingestion and transformation. Ensure integrations are secure, scalable, and compliant with industry standards and regulatory requirements (e.g., GxP). Support the onboarding of the company’s data aggregator Platform Management: Configure, optimize, and maintain Boomi and Snowflake environments. Manage user access, roles, and permissions for integration and data platforms. Implement best practices for security, performance, and scalability. Monitor integration and system performance, troubleshoot issues, and implement error handling, logging, and alerting. Lead the end-to-end AWS architecture supporting data integration and transformation, Snowflake integration, Analytics and BI, AI/ML workload management Data Modeling &amp; Analytics Enablement: Design and build robust data models and schemas to support business functions (Commercial, Clinical, R\&amp;D). Layer on visualization tools (Power BI, Tableau) for reporting and dashboards. Support&nbsp;BI and dashboarding initiatives&nbsp;and provide guidance on data access. Collaboration &amp; Documentation: Work closely with IT, Commercial, Clinical, Finance, and other areas of the business as well as external vendors to understand integration requirements. Document integration architecture, processes, and best practices. Provide ongoing support, enhancements, and documentation for existing integrations and platforms. AI Technology Foundry – Strategy and Build Lead the design and build-out of the Dyne AI technology Foundry, including Advanced analytics Machine learning Generative AI use case implementation Leadership, Collaboration &amp; Governance Act as a senior leader in the IT department and beyond; advising across the organization Provide mentorship and technical leadership to all those in IT Support vendor selection (e.g., MSP), contract evaluation and platform strategy Education and Skills Requirements: Bachelors in Computer Science required, Master’s degree preferred 10+ years of experience in integration engineering, data engineering, or related roles Hands-on experience with Boomi (design, deployment, administration) and Snowflake (configuration, optimization, data modeling) Strong understanding of APIs, web services (REST/SOAP), data formats (JSON, XML), and SQL Experience integrating ERP, CRM, HRIS, and other data platforms Proficiency with Power BI and Tableau for data visualization Experience in biotech or pharmaceutical environments, including integrations with 3PLs, specialty pharmacies, CROs, and clinical systems Understanding of compliance requirements (e.g., GxP, HIPAA) and data governance in life sciences Ability to work independently and manage multiple priorities in a fast-paced environment Strong communication and collaboration skills across technical and business teams Familiarity with NetSuite, Veeva, ADP, and Snowflake integrations Knowledge of cloud platforms such as AWS and security best practices Experience with clinical trial data, commercial sales data, and regulatory reporting Snowflake SnowPro certification preferred Boomi Developer certification preferred &nbsp;MA Pay Range$188,000&mdash;$244,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Director, Data, Integration & AI Engineering

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The&nbsp;Senior&nbsp;Director, Medical&nbsp;Information&nbsp;is responsible for&nbsp;establishing&nbsp;and leading the medical information function to ensure&nbsp;timely,&nbsp;accurate, balanced, and compliant scientific responses to unsolicited inquiries from healthcare professionals. This role plays a critical part in supporting the safe and&nbsp;appropriate use&nbsp;of the company’s products by delivering high-quality medical information and enabling scientific exchange. The&nbsp;person in this role&nbsp;has strong scientific&nbsp;expertise, experience in regulated environments, and the ability to build scalable medical information processes in a biotech setting.&nbsp; This position is based in Waltham, MA, with the option to work remotely.&nbsp;&nbsp;Primary Responsibilities&nbsp;Include:&nbsp; Establish and lead the medical information function, including strategy, processes, and execution&nbsp; Establish scalable medical information infrastructure, including inquiry intake, documentation, and response workflows&nbsp; Oversee&nbsp;the implementation&nbsp;and training&nbsp;of&nbsp;the medical inquiry intake portal and call center vendors and manage&nbsp;relationships&nbsp;going forward&nbsp; Develop high-quality medical information response documents (standard response letters, FAQs, backgrounders)&nbsp;and&nbsp;maintain&nbsp;medical information content aligned with product labeling, clinical data, and evolving scientific evidence&nbsp; Lead and oversee&nbsp;Medical, Legal, and Regulatory (MLR)&nbsp;review&nbsp;&nbsp; Ensure responses are scientifically&nbsp;accurate, balanced, up-to-date, and compliant with regulation&nbsp; Ensure&nbsp;appropriate escalation&nbsp;and coordination of safety, quality, and off-label inquiries&nbsp; Analyze inquiry trends to&nbsp;identify&nbsp;knowledge gaps, unmet medical needs, and opportunities to inform medical strategy&nbsp; Monitor metrics and quality indicators to ensure continuous improvement and compliance&nbsp; Education and Skills Requirements:&nbsp; Doctorate degree (MD, PhD, PharmD) with&nbsp;15+&nbsp;years of experience&nbsp;in&nbsp;medical information or medical affairs in rare diseases, neuromuscular diseases, or a related field&nbsp; Experience&nbsp;establishing&nbsp;or leading a medical information function is strongly preferred&nbsp; Strong understanding of regulatory, compliance, and pharmacovigilance requirements&nbsp; Excellent scientific writing and verbal communication skills&nbsp; Strong organizational and process-building capabilities&nbsp; High attention to detail and commitment to compliance and scientific integrity&nbsp; Ability to work effectively in a matrixed, fast-paced biotech environment&nbsp; Strong judgment in handling complex or sensitive inquiries&nbsp; MA Pay Range$230,000&mdash;$285,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Senior Director, Medical Information

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The&nbsp;Senior&nbsp;Director,&nbsp;Program Management&nbsp;(PM)&nbsp;is&nbsp;a&nbsp;critical role within the cross-functional development team&nbsp;responsible for&nbsp;facilitating&nbsp;and&nbsp;driving execution across the wide spectrum of activities&nbsp;required&nbsp;for successful development of one or more molecules. &nbsp;The&nbsp;PM&nbsp;partners&nbsp;closely&nbsp;with&nbsp;the&nbsp;Program Team Leader (PTL) and&nbsp;functional subject matter experts to ensure that plans are in place with&nbsp;appropriate detail&nbsp;and risk awareness&nbsp;to&nbsp;assure&nbsp;successful achievement of the goals of the development team.&nbsp;&nbsp;The&nbsp;PM&nbsp;ensures integration&nbsp;of&nbsp;these&nbsp;detailed functional plans&nbsp;into a holistic,&nbsp;cohesive,&nbsp;and comprehensive&nbsp;program plan that achieves the strategic goals of the&nbsp;development program. &nbsp;Given the inherent uncertainty associated with drug development in rare disorders,&nbsp;the PM&nbsp;maintains&nbsp;an agile mindset&nbsp;in order to&nbsp;effectively incorporate and react to&nbsp;emerging data and&nbsp;course correct&nbsp;as&nbsp;conditions dictate.&nbsp;&nbsp;Working in&nbsp;close&nbsp;partnership with&nbsp;the&nbsp;PTL, the PM&nbsp;effectively frames and&nbsp;facilitates&nbsp;discussions&nbsp;with&nbsp;team members and external experts&nbsp;to&nbsp;elicit&nbsp;clear&nbsp;recommendations and decisions&nbsp;by fully engaging with team members to consider multiple options with&nbsp;a focus on&nbsp;impact on quality, time,&nbsp;and cost. &nbsp;Their&nbsp;influence&nbsp;and engagement skills allow them to&nbsp;work with&nbsp;a highly motivated team and manage stakeholders&nbsp;at all levels of the company.&nbsp;&nbsp; This role is based in Waltham, MA without the possibility of being a remote role.&nbsp;&nbsp; Primary Responsibilities&nbsp;Include:&nbsp; Lead&nbsp;the operations of&nbsp;one or more&nbsp;high performing cross-functional teams, with focus on both the “what”,&nbsp;such as priorities,&nbsp;goal achievement, and resources, and the “how” of&nbsp;maintaining&nbsp;a&nbsp;challenging, collaborative, and sustainable team environment&nbsp; Partner with the PTL to&nbsp;identify&nbsp;short, medium, and long-term team priorities&nbsp;and propose path to address&nbsp; Drive&nbsp;execution of&nbsp;the established&nbsp;and&nbsp;aligned Program vision and strategy for bringing a life-changing medicine to patients in need&nbsp; Facilitate&nbsp;creation&nbsp;&amp; maintenance of core program strategy documents including&nbsp;Target&nbsp;Product&nbsp;Profile&nbsp;(TPP), Clinical Development Plan, Regulatory Strategy, and Supply Strategy&nbsp;in collaboration with cross-functional representatives&nbsp;&nbsp; Ensure&nbsp;that non-clinical, clinical, regulatory, and commercialization&nbsp;strategies and plans are aligned with the TPP and the overall Program Strategy&nbsp; Inspire development of an efficient plan to&nbsp;achieve development&nbsp;and commercialization&nbsp;strategy,&nbsp;optimizing&nbsp;for quality,&nbsp;speed&nbsp;and cost&nbsp; Ensure that program decisions are made in&nbsp;a timely,&nbsp;clear&nbsp;and efficient manner through interactions with the PTL, Program Team members, governance&nbsp;forums&nbsp;and other key stakeholders&nbsp; Accountable for&nbsp;creation and maintenance of&nbsp;detailed&nbsp;cross-functional&nbsp;plans and effective visual summaries thereof&nbsp;to&nbsp;instill&nbsp;awareness,&nbsp;build&nbsp;accountability and&nbsp;facilitate&nbsp;achievement&nbsp;&nbsp; Maintain clear and open communication with&nbsp;Program&nbsp;Team,&nbsp;Dyne Senior Leadership,&nbsp;and other stakeholders&nbsp;regarding&nbsp;program status, priorities,&nbsp;risks&nbsp;and needs, and&nbsp;facilitate&nbsp;appropriate strategic&nbsp;decision-making&nbsp; Partner with Head of Program Management to evolve Program Management discipline to meet needs of a growing organization that intends to launch a portfolio of disease products&nbsp; Keep abreast of emerging developments&nbsp;regarding&nbsp;research and development in the fields of muscle diseases and oligonucleotide drug discovery and development&nbsp; Foster a culture of collaboration, innovation, discovery, and&nbsp;cutting-edge&nbsp;research culture focused on scientific excellence, open communication, and continual improvement&nbsp; Education and Skills&nbsp;Requirements:&nbsp; Proven and respected team&nbsp;member&nbsp;with:&nbsp;&nbsp;&nbsp; Bachelor’s degree in science or related field;&nbsp;Advanced&nbsp;degree in a scientific discipline or MBA&nbsp;preferred&nbsp; 15+&nbsp;years of&nbsp;relevant&nbsp;experience in&nbsp;biotech/pharmaceutical industry in positions&nbsp;of increasing responsibility&nbsp;in drug development&nbsp;&nbsp; Experience with late-stage clinical development and commercial stage&nbsp;programs&nbsp;required&nbsp; Experience with neuromuscular diseases a plus&nbsp; Exceptional&nbsp;communication skills (verbal, written, presentation) and ability to communicate with across a broad group of&nbsp;stakeholders and teams&nbsp; Proficient with&nbsp;Microsoft Office 365&nbsp;applications,&nbsp;Smartsheet and other PM management workspace collaboration tools&nbsp; Expert at&nbsp;cross-functional&nbsp;teamwork&nbsp;and influencing without direct authority&nbsp; Demonstrated experience in&nbsp;working with&nbsp;highly effective teams and guiding teams and organizations in making complex and high-stakes data-driven decisions&nbsp; Passionate about developing and commercializing life-transforming therapies for patients with severe and life-threatening diseases&nbsp;&nbsp; Adept at operating in cross-functional matrix teams, developing effective relationships based on mutual trust and effective communication and thrives in a fast-paced, patient-focused environment&nbsp; Proven ability to&nbsp;establish&nbsp;and maintain credible and trust-based relationships&nbsp;&nbsp; Outstanding sense of urgency and ability to&nbsp;help&nbsp;pace&nbsp;the team’s&nbsp;work&nbsp;in highly competitive environment&nbsp; Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product&nbsp; Comfort with ambiguity and ability to provide steadiness and consistency in environment of shifting priorities&nbsp; Ability to lead&nbsp;without authority through&nbsp;complex&nbsp;and ambitious&nbsp;projects in a cross-functional team environment and high-pressure circumstances&nbsp; Comfortable in a results-driven, highly accountable environment where you can make a clear impact&nbsp; Team player who listens effectively and invites response and discussion&nbsp;&nbsp; A collaborator who communicates in an open, clear, complete,&nbsp;timely&nbsp;and consistent manner MA Pay Range$233,000&mdash;$285,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Senior Director, Program Management

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn&nbsp;and Facebook.Role Summary: The Associate Director, Patient Advocacy &amp; Operations works as part of the Corporate &amp; Patient Affairs (C&amp;PA) team with two key areas of focus: 1) Cultivating and supporting strategic partnerships with patient advocacy organizations and 2) day-to-day management of key Patient Advocacy and Corporate Affairs operations. Reporting to the VP, Patient Advocacy, this role is highly integrated with internal cross-functional teams and partners with external organizations. This role is based in Waltham, MA and does not offer a remote option.&nbsp; Primary Responsibilities:&nbsp; In collaboration with the VP of Patient Advocacy, partner closely with advocacy leaders and the broader patient community to advance key initiatives, including but not limited to: Executing the patient advocacy strategy in alignment with corporate objectives Fostering strong, strategic relationships with patient leaders, caregivers, and advocacy organizations to inform company programs and priorities. Leading the planning and management of Patient Community Advisory Panels/Boards. Conducting one-on-one engagements with patient advocacy leaders to identify‑ needs, insights, and opportunities for collaboration. Supporting clinical trial awareness and recruitment efforts through patient engagement and community focused‑ initiatives. Collaborating with Medical Affairs, Marketing, Market Access/Patient Services, and Corporate Affairs to integrate the patient voice into R&amp;D, clinical trial design, and commercialization efforts. Representing Dyne at patient advocacy events, conferences, and advisory boards. Collecting, synthesizing, and sharing patient community insights across functional teams. Identifying and coordinating community participants for Dyne-led events (internal and external). Partner with the VP of Patient Advocacy to plan and execute conference and patient advocacy organization (PAO) engagement activities: Supporting Dyne’s presence at patient advocacy and select scientific/medical conferences including event planning, session development, patient-facing materials, symposia, presentations, and on-site event execution. Staffing events; willingness to travel approximately 20%. Serve as the operational lead for the Patient Advocacy Grants, Sponsorships &amp; Donations committee, including budget oversight and end-to-end management of the submission process, such as coordinating with requestors, ensuring proper documentation, and overseeing contracting and payment workflows. Support the planning and execution of enterprise-wide events (e.g., advocacy walks) that bring patient community voices into the organization, serving as a Patient Advocacy representative on cross functional teams and supporting coordination tasks when needed. to support the delivery of high-quality experiences. Manage and own patient engagement–related contracting, ensuring compliance and timely execution. Lead operational processes for advancing patient advocacy materials through Medical Legal Review (MLR), ensuring accuracy, alignment, and compliance. Education and Skills Requirements: Bachelor’s degree in a relevant field required (social work, genetic counseling, nursing, public health preferred).&nbsp; 6+ years of experience in patient advocacy in the biotech/pharmaceutical industry, preferably within a clinical stage biotechnology company. Proven experience developing and sustaining partnerships with patient advocacy organizations and community leaders. Deep understanding of rare diseases and the unique needs of rare disease communities. Strong understanding of the Patient-Focused Drug Development (PFDD). Exceptional communication, diplomacy, and cross-functional collaboration skills. Experience managing budgets, teams, and compliance sensitive partnerships within a regulated environment. Proven experience partnering with clinical teams on trial awareness and recruitment efforts. Broad knowledge of the biopharma landscape and a solid working understanding of the drug development process. Strong interpersonal skills with the ability to influence without authority and work effectively across diverse functions and personalities. Compassionate, patient centered mindset, and a high degree of personal integrity. Ability to manage multiple simultaneous projects, navigate ambiguity, and thrive in a fast paced, dynamic environment. Experience with Patient Advocacy sponsorship contracting processes. Proven operations experience and excellent project, vendor, and budget management capabilities with a demonstrated ability to deliver results. Strong organizational skills and attention to detail. Bilingual fluency in Spanish is a plus. Overnight travel will be required; up to 20%. &nbsp; &nbsp; &nbsp;MA Pay Range$155,000&mdash;$200,000 USD&nbsp; The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.&nbsp; Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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