Compass Therapeutics is a biotechnology company focused on developing antibody therapeutics to treat cancer and autoimmune diseases. The company's innovative approach harnesses the power of the immune system to target specific disease pathways, offering promising new treatment options for patients in need. With a dedication to advancing precision medicine and improving patient outcomes, Compass Therapeutics is at the forefront of cutting-edge research and development in the field of biopharmaceuticals.

Compass Therapeutics, Inc. is a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases. Compass’ scientific focus is on the relationship between angiogenesis, the immune system and tumor growth. Our pipeline of novel product candidates is designed to target multiple critical biological pathways required for an effective anti-tumor response. These include modulation of the microvasculature via angiogenesis-targeted agents, induction of a potent immune response via activators on effector cells in the tumor microenvironment, and alleviation of immunosuppressive mechanisms used by tumors to evade immune surveillance. We plan to advance our product candidates through clinical development as both standalone therapies and in combination with proprietary pipeline antibodies based on supportive clinical and nonclinical data. We were founded in 2014 and are headquartered in Boston, Massachusetts. For more information, visit www.compasstherapeutics.com.Our CMC team is seeking a highly motivated and hands-on Principal Analytical Scientist, reporting to our Director of Analytical Development. The ideal candidate will have a proven track record as a key analytical lead for monoclonal antibody programs and desires to be part of a fast paced, collaborative team. This position reports onsite a minimum of&nbsp;4 days/week to our office in Brighton, MA. Responsibilities:• &nbsp; &nbsp;Lead analytical development processes, support CMC strategies, and manage the execution of CMC activities at CMO/CDMO partners across all of our clinical-stage antibody assets and drug candidates in support of commercialization&nbsp;• &nbsp; &nbsp;Ensure that Compass CMC department goals are on track to reach milestones within established timelines, while adhering to quality standards and applicable regulations• &nbsp; &nbsp;Manage the external day-to-day development, optimization, qualification, and validation of GMP analytical methods used for release, stability, and characterization of antibody products• &nbsp; &nbsp;Accountable for method development, analytical activities and control strategy supporting drug substance (DS) and drug product (DP) release and stability testing; including quality control (QC) activities and troubleshooting• &nbsp; &nbsp;Manage the successful transfer of analytical methods to external partners, providing hands-on technical support and troubleshooting to ensure reliable execution of QC testing• &nbsp; &nbsp;Develop and lead phase‐appropriate analytical control strategy including assessment of critical quality attributes (CQAs), justification of specifications and establishment of test methods for early-stage programs• &nbsp; &nbsp;Responsible for managing the lifecycle of NonGMP/GMP stability studies across various phases following ICH stability requirements for setting shelf life/expiry; from initial pull schedules to final testing and disposal• &nbsp; &nbsp;Summarize stability data to help establish self-life specifications and re-test periods based on statistical trends and regulatory requirements, including IND and BLA• &nbsp; &nbsp;Ensure all analytical data and documentation adhere to GxP and global regulatory standards (e.g., GLP/GMP, FDA, EMA, ICH)• &nbsp; &nbsp;Author and review CMC sections of regulatory filings (INDs, BLAs) related to analytical methods, specifications, and stability data• &nbsp; &nbsp;Foster strong effective relationships and liaise with internal and external stakeholders; including with cross-functional teams such as Process Development, Quality Assurance, and Regulatory Affairs Qualifications:• &nbsp; &nbsp;PhD in Analytical Chemistry, Biochemistry, Protein Science, or a related discipline with 8+ years of experience, or a BS/MS in life sciences with 12+ years, of analytical development in the biotech industry&nbsp;• &nbsp; &nbsp;Prior experience working in or directly managing a CDMO QC laboratory environment; ability to develop and implement analytical control strategies&nbsp;• &nbsp; &nbsp;Extensive experience leading analytical CMC activities, must include method development, qualification/validation for large molecule biologic(s); preferred experience with bispecific antibodies• &nbsp; &nbsp;Deep technical expertise in protein characterization, quality control (QC) testing, and regulatory expectations for biologics• &nbsp; &nbsp;Demonstrated problem solving and leadership skills; proven success effectively leading project matrix teams internally and externally, and managing external CDMOs&nbsp;• &nbsp; &nbsp;Demonstrated expertise applying analytical techniques for protein analysis, including binding ELISAs, chromatographic purity assays, cell-based potency assays, extended characterization, routine compendial assays, and analytical comparability in support of commercialization• &nbsp; &nbsp;Experience identifying critical risks, ability to provide appropriate solutions and mitigate risks; strong work principles and ethical standards are required&nbsp;• &nbsp; &nbsp;Excellent understanding of cGMP requirements, ICH (Q2, Q6B) and regulatory guidelines as applicable, experience authoring CMC regulatory documents is a plus• &nbsp; &nbsp;Strong attention to detail with the ability to balance multiple project objectives in a fast-paced, collaborative work environment• &nbsp; &nbsp;Excellent written and verbal communication skills, with the ability to clearly articulate complex analytical concepts and data to diverse audiences• &nbsp; &nbsp;This position allows for development opportunities across CMC functional areas as interested• &nbsp; &nbsp;This position may require up to 10% travel &nbsp;Base Salary Range in Job Post$140,000&mdash;$188,000 USDAt Compass, we provide employees with an inclusive offering of benefits and a competitive compensation package. We offer our employees competitive salaries, discretionary bonuses, and meaningful equity participation. Our innovative benefits support the health and wellness of our employees; from medical, dental and vision benefits to health reimbursement arrangement, flexible spending accounts, sponsored gym membership, an employee assistance program, life insurance, and much more. We also provide 401(k) and Roth 401(k) programs with a 6% company match, and other resources for financial wellness. Additional benefits include commuter reimbursement, subsidized company parking, cell phone reimbursement, Summer Fridays, and substantial paid time off including a winter shut down week. Our Mission at Compass is to develop next generation antibodies into transformative cancer therapies that improve patients’ lives. Our Compass Core Values guide us in achieving this. We are mission-focused and share a passion for science and creativity that help us innovate in all that we do. Our unique community promotes authenticity, diversity of thought, and collaborative teamwork. &nbsp; We invest in the growth and development of our teams and individuals through programs such as company-wide trainings, cross-functional collaboration and job shadowing, tuition reimbursement, employee recognition awards, and a comprehensive performance management cycle. Also, our Compass Culture Committee empowers employee-organized events that celebrate wins, drive initiatives, support local philanthropy, and align with our mission and values.

Principal Analytical Scientist, CMC

Compass Therapeutics, Inc. was founded in 2014 and is headquartered in Boston, MA. We are an oncology-focused biopharmaceutical company discovering and developing proprietary antibody-based therapeutics to treat multiple diseases. Our robust pipeline currently includes four clinical assets spanning all phases of studies, novel mechanisms of action, and first-in-class or best-in-class potential across multiple tumor types. Our lead clinical-stage asset, tovecimig, has completed a randomized late-stage biliary tract cancer study and we are preparing for a BLA submission. We are now at an exciting inflection point as we build out a commercial organization to support our first product launch. This is a unique and pivotal moment to join us and help make a meaningful impact on patients’ lives. For more information, visit www.compasstherapeutics.com. Position Overview: Our Legal team&nbsp;is seeking a commercially experienced and business-minded Senior Counsel, Commercial Legal &amp; Compliance reporting directly to our General Counsel. This high-impact role will lead the development of our commercial legal and compliance capabilities and framework in preparation for a BLA submission and potential first product launch. This role will partner cross-functionally to enable compliance commercialization while mitigating nuanced legal and regulatory risk specific to the life sciences industry. The ideal candidate is a pragmatic problem-solver who can balance legal rigor with business practicality in a fast-moving environment. We seek candidates who appreciate our unique opportunity to impact patients in need of new therapeutic options. This position is on-site at our office in Brighton, MA with an expectation of 4 days/week in the office. Responsibilities: Lead the development and implementation of the company’s commercial legal and healthcare compliance infrastructure in advance of launch Serve as primary legal advisor to the Commercial and Medical Affairs functions through commercial buildout and commercial launch activities, ensuring milestones are met within compliance standards Design, implement, and manage a robust healthcare compliance program in preparation for commercial launch, including policies, procedures, training, and monitoring activities Structure and implement a cross-functional promotional review and approval process, encompassing review of pre-approval communications, promotional materials, and other external content, all aligned with FDA promotional regulations and industry standards Build strong relationships and lead strategic planning to successfully collaborate and execute across teams: sales, marketing, market access, supply and distribution, pricing, and reimbursement Represent the Legal function on future brand, product, and launch teams in collaboration with internal and external stakeholders, including structuring, drafting, and negotiating complex commercial agreements Collaborate closely with medical organization, including medical affairs, to provide practical advice on strategies, plans, and tactics for scientific exchange and field activities Proactively assess risks and advise on our compliance with applicable healthcare laws and regulations, including FDA and OIG guidance, fraud and abuse laws, PhRMA Code, data privacy and security laws, and transparency and price reporting requirements Act as the primary legal resource on interactions with HCPs, including FMV and needs assessments, advisory board structuring, and consultant and speaker management Build and oversee a robust transparency, aggregate spend tracking, and reporting program Develop innovative legal solutions in a fast-paced environment and across a range of disciplines Draft, negotiate, and advise on a broad range of sophisticated commercial contracts and transactions, including product sales, supply and distribution, master services, software and technology, licensing, and strategic collaborations Support business development activities, including strategic collaborations and partnerships Contribute to broader corporate legal needs as we evolve and expand our operations, including managing outside counsel where specialized advice is required Qualifications: Bachelor’s degree, J.D. from a top law school, and active bar membership in at least one U.S. jurisdiction; current license to practice in Massachusetts preferred 7+ years of relevant legal experience representing clients in the life sciences industry (in-house or at a law firm); in-house pharmaceutical or biotechnology experience preferred Deep knowledge and understanding of U.S. healthcare laws and regulations, including the Anti-Kickback Statute, False Claims Act, FDA promotional regulations, OIG guidance, PhRMA Code, Sunshine Act, HIPPA, and various state analogues; familiarity with government pricing programs (Medicaid Best Price, AMP, 340B) is nice to have Hands-on experience building comprehensive compliance infrastructure, including codes, policies, procedures, and other key components thereof, in a commercial setting Prior experience launching oncology products or specialty pharmaceuticals preferred, with a deep understanding of biopharmaceutical legal and regulatory risks, with MLR/PRC expertise Experience drafting and negotiating complex commercial agreements in the life sciences space Ability to communicate effectively and clearly to a diverse set of audiences ranging from junior employees to senior executives to the board of directors Strong analytical and problem-solving skills; ability to think creatively and develop innovative legal strategies; adaptability and nimbleness Intellectual curiosity and a passion for science Base Salary Range in Job Post$210,000&mdash;$290,000 USDOur mission is to develop next generation antibodies into transformative cancer therapies that improve patients’ lives. We built our core values from the employees up and each and every one of us is essential to achieving our mission. We are mission-focused, share a passion for science and creativity that help us innovate in all that we do. Our unique culture and community promotes authenticity, diversity of thought, and collaborative teamwork. &nbsp; Compass provides employees with a comprehensive and market-leading compensation and benefits package. Our compensation package includes a base salary, discretionary bonus, and meaningful equity participation for every employee. Our innovative benefits offerings support holistic employee health and wellness - from subsidized medical, dental and vision premiums to health reimbursement arrangement, flexible spending accounts, gym membership, employee assistance program, life insurance, and much more. We also offer 401(k) and Roth 401(k) programs with a 6% company match. Additional benefits include company parking, commuter reimbursement, and substantial vacation and leave policies, including summer Fridays, and a winter shut down week. Beyond traditional benefits, we invest in the growth and development of our teams and individuals through programs such as company-wide training, tuition and training reimbursement, recognition awards, and comprehensive performance management. With our Compass Culture Committee, we grow and preserve our culture through: events that build camaraderie and celebrate wins both large and small, diverse employee-driven initiatives, participation in charitable causes, and other programs that align with our values.

Senior Counsel, Commercial Legal & Compliance

Compass Therapeutics, Inc. was founded in 2014 and is headquartered in Boston, MA. We are an oncology-focused biopharmaceutical company discovering and developing proprietary antibody-based therapeutics to treat multiple diseases. Our robust pipeline currently includes four clinical assets spanning all phases of development, with novel mechanisms of action, and first-in-class or best-in-class potential across multiple tumor types. Our lead clinical-stage asset, tovecimig, has completed a randomized late-stage biliary tract cancer study and we are preparing for a BLA submission. We are now at an exciting inflection point as we scale our organization to support our first product launch. This is a unique and pivotal moment to join us and help make a meaningful impact on patients’ lives. For more information, visit www.compasstherapeutics.com. Our Clinical team is seeking a hands‑on strategic Senior Manager, Clinical Statistical Programmer, reporting to our Director of Biostatistics. The ideal candidate will have a proven track record of successfully leading clinical safety analysis and programming across multiple programs, in a fast-paced environment. This role combines deep technical expertise in SAS and R with ownership of ongoing safety maintenance and leadership in modern data visualization platforms. The individual will support active trials, long‑term safety monitoring, and the integration of complex data streams, including translational and real-world data (RWD). This position works onsite 4 days/week in the Brighton, MA office. &nbsp;Responsibilities Lead Statistical Programming processes, support Clinical strategies, and manage the execution of programming activities across all of our clinical-stage antibody assets and drug candidates in support of commercialization. Ensure that Compass Clinical department goals are on track to reach milestones within established timelines, while adhering to quality standards and applicable regulations. Provide continuous programming support for active studies, ensuring safety outputs (AEs, SAEs, Labs, Vitals) remain current, validated, and inspection readiness. Lead the production of recurring safety outputs and data packages for Data Safety Monitoring Boards and internal safety review committees. Oversee medical coding outputs (MedDRA, WHO Drug) and perform clinical-to-safety database SAE reconciliation to ensure data integrity. Lead the development of interactive dashboards and exploratory tools using platforms such as Spotfire, R Shiny, or R-based frameworks. Create and maintain customized patient profiles to facilitate efficient medical monitor and safety physician reviews. Partner with Biostatistics and Clinical Safety teams to translate clinical questions into actionable visual analytics and early trend identification. Build and maintain reusable SAS/R macros and standard templates to improve programming efficiency and consistency across the portfolio. Develop and execute periodic data quality checks to identify anomalies, trends, or emerging issues early in the study lifecycle. Design and maintain complex derived variables and analysis-ready datasets to support evolving reporting requirements. Ensure all programming documentation and datasets meet high standards for regulatory submissions and audit readiness. Support the roadmap for future real-world data (RWD) and safety data streams. Qualifications Bachelor’s degree in Statistics, Biostatistics, Computer Science, Mathematics, or a related field, and advanced degree is preferred. 8+ years of clinical statistical programming experience within the Pharmaceutical, Biotech, or CRO industry. Advanced proficiency in SAS (SDTM/ADaM) and R/Python for clinical trial analysis and data visualization. In-depth knowledge and proven expertise of clinical safety data structures, medical coding standards, and SAE workflows. Demonstrated experience leading implementation and maintaining data visualization platforms (e.g., Spotfire, R Shiny) in a clinical environment. Preferred experience handling&nbsp;translational data (e.g., biomarkers, genomics, or PK/PD integration) and its associated complexities. Prior experience acting as a programming lead or senior technical contributor with oversight of FTE or vendor-provided deliverables is ideal. Exposure to post-marketing safety data or the analysis of real-world evidence (RWE) is preferred. Experience identifying critical risks, ability to provide appropriate solutions and mitigate risks; strong work principles and ethical standards are required. Strong attention to detail with the ability to balance multiple project objectives in a fast-paced, collaborative work environment. Excellent written and verbal communication skills, with the ability to clearly articulate complex data to diverse audiences. Base Salary Range in Job Post$140,000&mdash;$198,000 USDOur mission is to develop next generation antibodies into transformative cancer therapies that improve patients’ lives. We built our core values from the employees up and each and every one of us is essential to achieving our mission. We are mission-focused, share a passion for science and creativity that help us innovate in all that we do. Our unique culture and community promotes authenticity, diversity of thought, and collaborative teamwork. &nbsp; Compass provides employees with a comprehensive and market-leading compensation and benefits package. Our compensation package includes a base salary, discretionary bonus, and meaningful equity participation for every employee. Our innovative benefits offerings support holistic employee health and wellness - from subsidized medical, dental and vision premiums to health reimbursement arrangement, flexible spending accounts, gym membership, employee assistance program, life insurance, and much more. We also offer 401(k) and Roth 401(k) programs with a 6% company match. Additional benefits include company parking, commuter reimbursement, and substantial vacation and leave policies, including summer Fridays, and a winter shut down week. Beyond traditional benefits, we invest in the growth and development of our teams and individuals through programs such as company-wide training, tuition and training reimbursement, recognition awards, and comprehensive performance management. With our Compass Culture Committee, we grow and preserve our culture through: events that build camaraderie and celebrate wins both large and small, diverse employee-driven initiatives, participation in charitable causes, and other programs that align with our values.

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