Prime Medicine is a biotechnology company focused on developing innovative RNA-based therapeutics to treat genetic diseases. The company's cutting-edge research and technology aim to revolutionize the field of medicine by providing personalized treatments for patients with rare and common genetic disorders. With a dedicated team of scientists and experts, Prime Medicine is committed to advancing the future of healthcare through its groundbreaking approach to gene therapy.

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Prime Medicine is seeking a Contract GMP Associate / Technician to support GMP operations across our facility. This hands-on role will involve execution of procedures in compliance with internal standards and regulatory guidelines. The successful candidate will work collaboratively to ensure operational readiness, instrument care, and routine support of GMP activities. Responsibilities Prepare materials and solutions according to established procedures and documentation. Support daily activities related to instrument/equipment operation, maintenance, and troubleshooting. Follow standard operating procedures and maintain compliance with internal quality standards. Document work in accordance with data integrity and GMP expectations. Support facility workflows, workspace upkeep, and readiness of equipment and spaces Qualifications: Associate’s or Bachelor’s degree in a chemistry, biochemistry, or related field, or equivalent experience. Minimum of 1-2 years of experience in a GMP or other regulated environment. Demonstrated ability to follow written procedures and maintain detailed records. Strong organizational, communication, and collaboration skills. Mechanical aptitude and experience assembling/disassembling GMP equipment and instruments. Familiarity with standard lab, chemistry, and bioprocess equipment and workflows. &nbsp;Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Contractor, GMP Technician

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: The Lab Technician plays a vital role in supporting the daily operations of our chemistry laboratory, ensuring a clean, safe, and well-stocked working environment for scientific staff and operations. This position is responsible for inventory management, lab organization, safety compliance, and general operational support. The ideal candidate is detail-oriented, proactive, and comfortable working in a fast-paced scientific environment.&nbsp; Key Responsibilities: Follow established Quality SOPs to track, receive, and organize inventory, including reagents, lab consumables and PPE in LIMS and CMS. Manage and monitor laboratory equipment by coordinating service/repairs as needed and ensuring documentation is to Quality standards. Update and maintain instrument records in a qualified asset management system. Assist with internal transport and movement of 55-gallon solvent barrels via the use of a Powered Industrial Truck (keg lifter). Ensure compliance with safety policies, including proper storage and disposal of chemicals, biohazards, and sharps. Assist with lab documentation including SOPs, safety records, and equipment logs.&nbsp; Coordinate with vendors, service providers, and building facilities as needed. Participate in audits, safety inspections, and emergency preparedness drills. Qualifications: 2+ years of experience in a laboratory or lab operations role preferred. Strong organizational skills and attention to detail. Ability to work independently and manage multiple priorities. Familiarity with common lab equipment and safety practices. Excellent communication and interpersonal skills. Proficiency with basic software tools (e.g., Microsoft Office, inventory management systems). Nice to Have:&nbsp; Experience in a regulated environment (e.g., GLP, GMP, etc.). Knowledge of EHS protocols. Familiarity with LIMS or lab tracking software. Experience with high volume solvent systems. Working Conditions:&nbsp; This position requires on-site presence in a laboratory setting. Will involve lifting of boxes, carboys or lab supplies (up to 50 lbs). Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Contractor, Lab Operations Technician

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Prime Medicine is seeking a Contractor, Patient Advocacy and Medical Affairs Specialist to build strong relationships with patient communities and lead strategic collaborations with patient advocacy organizations across all therapeutic programs. Reporting to the Vice President of Clinical Science, this role will also work closely with the Clinical Development team to support additional medical affairs initiatives, including conference and publication planning, Key Opinion Leader (KOL) coordination, and clinical study support as it relates to patient engagement. The ideal candidate may be remote but should be able to be on site for key events and be willing to travel ~15% of the time, including conferences and patient advocacy meetings.&nbsp; Responsibilities Support and help execute Prime Medicine’s patient advocacy strategy and our ‘Patients First’ philosophy. Identify, build and maintain strong relationships with patient advocacy communities, particularly in rare disease communities, and support sponsorship opportunities. Ensure the patient experience is heard within Prime to help shape clinical and regulatory development planning Build educational materials for patient communities around genetic medicines and understand where needs or opportunities may exist for support Coordinate, plan, and manage budgets for patient advocacy events and speakers. Collaborate cross-functionally with Clinical Development, Corporate Communications and Legal teams as needed, ensuring compliance around interactions with stakeholders Assist with KOL coordination, and conference/publication and external presentation planning activities as needed. Qualifications: Minimum B.S or B.A. candidate for Biology, Health Sciences, Business, Marketing, or similar field. Minimum 2 years experience in patient engagement or organizational strategy with advocacy groups in a biotech or pharma setting. Rare disease experience strongly preferred. Familiarity with medical affairs and scientific communication planning, including KOL engagement and conference/publication planning activities preferred. Strong interpersonal, oral, and written communication skills; ability to quickly build rapport with diverse stakeholders. &nbsp;&nbsp;Ability to build trust and rapport with patients, families and caregivers through exceptional listening skills. Understanding of compliance requirements for patient advocacy and familiarity with the drug development process; genetic therapy experience a plus Excellent organizational and collaboration skills and ability to manage multiple projects in a matrixed environment, including event planning. Ability to travel occasionally to patient advocacy events or conferences. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Contractor, Patient Advocacy and Medical Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Join our collaborative, agile and fast-paced Liver Programs &amp; Development Sciences team to develop Prime Editors that could help patients in rare diseases and beyond. Reporting to the Vice President, Liver Programs &amp; Development Sciences, the successful candidate will be responsible for leading the strategic oversight of all safety (GLP and non-GLP) and tolerability studies in rodents, NHP and other appropriate animal models, to be conducted either internally and/or at external contract research laboratories within the US and internationally. The ideal candidate must exhibit exceptional functional expertise, collaborative behavior and be comfortable to excel in cross-functional matrixed project team environments, deliver results in a timely manner and have excellent communication skills to effectively communicate to managers, project teams and leaders in the organization. The ideal candidate will be onsite 5 days a week in Cambridge, MA.&nbsp; Responsibilities Toxicology strategy and sub-team leadership Develop and own the global toxicology strategy for portfolio programs from discovery through IND/NDA submissions Provide expert analysis on nonclinical safety findings, offering actionable guidance to cross-functional teams (Discovery, DMPK, Clinical, Pharmacovigilance) Study Design, Execution &amp; Oversight Lead the design and oversight of GLP and non-GLP toxicology studies, including general, genetic, germline transmission, reproductive, carcinogenicity, safety pharmacology, and toxicokinetics Manage CRO relationships from selection to monitoring to ensure scientific rigor, timelines, budgets, and regulatory compliance Cross-functional Influence &amp; External Collaboration Act as subject-matter expert across project teams, guiding risk assessment strategy and decision-making Collaborate with pharmacology and research team to select predictive models and explore mechanisms of toxicity in the process of lead optimization and development candidate selection Lead IND-enabling studies and effort to establish NOAEL and TI. Collaborate with Clinical to support the translation from nonclinical to clinical testing. Collaborate with TDO to support the establishment of safe and well characterized products, bridge nonclinical and clinical materials, evaluate excipient and novel component safety and manage risk from process impurities Regulatory Submissions &amp; Documentation Collaborate with Regulatory by authoring and reviewing nonclinical sections of regulatory submissions: INDs, CTAs, IBs, BLAs, NDAs, NDAs/MAAs, and responses to health authority inquiries Collaborate and support Research, Clinical and TDO in respective sections in regulatory document where safety and toxicity are tightly connected among studies conducted in different line functions Serve as company’s nonclinical toxicology representative in meetings with regulators (FDA, EMA, ICH) Qualifications: PhD in Toxicology, Pharmacology, or related field (DABT certification preferred) 10-12+ years of industry experience in pharmaceutical/biotech toxicology Expert knowledge of toxicology disciplines: general, developmental/reproductive, safety pharmacology, carcinogenicity, toxicokinetics Demonstrated track record managing GLP studies, CRO relationships, and regulatory submissions across lifecycle stages Excellent scientific writing skills for regulatory and clinical documents; strong oral communication for both internal and external engagements Deep familiarity with GLP regulations, FDA/EMA/ICH guidelines, and health authority interactions Proven ability to lead cross-functional teams under tight timelines in a dynamic biotech or pharma environment. Strong interpersonal and organizational skills, with a high degree of attention to detail. Ability to deal with competing priorities, strong reasoning, detail oriented and creative problem-solving ability is essential “Do-what-it-takes” approach to problem solving and prospective thinking. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view. Independently motivated, detail oriented and good problem-solving ability. Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities. Positive, outgoing and collaborative attitude with a passion for helping patients using innovative science Be ready to embrace the principles of the Prime culture Preferred Experience Experience in genomic medicine (gene transfer and/or gene editing) drug development History of published work and presentations at scientific conferences Experience evaluating assets for in-licensing or business development due diligence Experience with in silico or translational toxicity screening models. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Director of Safety Assessment

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: Prime Medicine is seeking a patent agent to join our highly skilled legal group. This position will report directly to our Senior Director of Intellectual Property. In this role you will work in a fast-paced, collaborative environment on a broad range of intellectual property matters in the emerging field of gene editing therapeutics. You will work directly with company scientists and the other members of the legal team to help to build, develop, and maintain a strong IP portfolio, protecting Prime Medicine’s technology platform and pipeline. Responsibilities: Conduct scientific and technical research and provide support to the IP and legal group. Work directly with Prime’s scientists to understand new technological developments and inventions and collaborate with company patent attorneys on patent filings. Conduct patent and scientific literature searches, and analyze patents and scientific technical documents to assist patent attorneys in patent prosecution, counseling, and litigation. Draft and prosecute domestic and foreign patent applications under supervision of company patent attorneys. Qualifications: At least one year of experience as a practicing patent agent in the life sciences field. PhD in Molecular Biology, Genetics, Biochemistry, or a related discipline required. Registered to practice before the U.S. Patent and Trademark Office (USPTO). Strong preference for candidates with experience in gene editing and CRISPR technologies. Excellent academic credentials with strong oral and written communication skills. Excellent organizational skills and attention to detail. Proficient in Microsoft Office (Word, Outlook, and Excel). Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Patent Agent

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Join and a collaborative, agile and transformative Clinical Development Operations (CDO) team by leading and contributing to transformative clinical programs for patients in rare diseases and beyond.&nbsp; Reporting to the Director of Clinical Operations, the successful candidate will be responsible for the operational execution of clinical trials within our liver directed gene therapy portfolio and will effectively lead the study start-up, implementation, and management of our studies, ensuring adherence to timelines, budget, and quality standards in support of regulatory filings. The ideal candidate must be comfortable overseeing and managing cross-functional study teams, including internal stakeholders and external vendors.&nbsp; The ideal candidate will be able to be onsite 1-2x/week in our Watertown office.&nbsp; Responsibilities You will oversee the day-to-day operations of study execution, with a focus on site oversight from study startup to study closeout, patient enrollment, monitoring, compliance, and data flow and metrics from the clinical sites, CROs and vendors. Lead a dynamic cross-functional team to ensure study deliverables are met on time and within budget guidelines, while ensuring quality in accordance with the protocol and ICH GCP guidelines. Initiate and manage study-level timelines; drive study startup activities, including site feasibility and selection, regulatory submissions, and site activation. Participate in the development and review and provide clinical operations input into key clinical documents such as the protocol, investigator brochure, CRFs, regulatory documents, clinical study reports and other documents and plans as appropriate. Develop critical study documents including informed consent forms, study conduct documents such as study manuals, the Study Operations Manual, study tools, etc. Train team members and site staff, including vendors, as needed Support the identification and onboarding of new vendors, including contract and budget negotiations. Manage invoice and budget tracking for individual studies and provide input into budget forecasting activities. Perform and document study level sponsor oversight of outsourced clinical activities, including oversight to ensure that safety concerns and/or adverse events are identified and appropriate responses to such concerns are developed and executed. Partner with clinical supply chain to help manage study level clinical supply demand Ensure reliable quality data are delivered by reviewing monitoring reports, protocol deviations, clinical data listings and performing or overseeing site monitoring visits, as needed. Develop action plans to address protocol compliance, safety, data and administrative issues with clinical sites and CROs. Develop and maintain strong, collaborative relationships with key stakeholders within and external to Prime Medicine. Participate in clinical operations workstreams and SOP development for critical department initiatives. Assist with the onboarding and mentoring of new or junior clinical operations associates; support oversight and management of consultants. Qualifications: BS/BA/RN Degree in science or a health-related field is preferred Minimum 7 years relevant industry clinical development experience, with 2+ years of independent trial management preferred. Sponsor experience is strongly preferred. Experience and understanding of drug development and global clinical trial operations Pivotal clinical trial oversight, or closely relevant experience required, and gene therapy experience preferred. Experience with all aspects of trial and site startup, CRO, vendor and laboratory management Familiarity with clinical data review and data management processes, including Data Monitoring Committees Must be able to travel up to 25%, domestically and internationally Creative problem-solver with excellent verbal and written communication skills Strong interpersonal and organizational skills, with a high degree of attention to detail. Ability to deal with competing priorities, strong reasoning, detail oriented and creative problem-solving ability is essential Ability to lead a cross-functional team, with the potential to lead multiple projects; be willing to work with tight timelines and to multi-task in a fast-paced environment with changing priorities with a sense of urgency Excellent knowledge of GCP, ICH and FDA regulations; working knowledge of international regulations in the EU preferred “Do-what-it-takes” approach to problem solving and prospective thinking. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view. Independently motivated, detail oriented and good problem-solving ability. Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities. Positive, outgoing and collaborative attitude with a passion for helping patients using innovative science Be ready to embrace the principles of the Prime culture Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Clinical Trial Manager

Fall 2025 Co-op: Medical Writing & Clinical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a diligent, motivated, and enthusiastic co-op for the Spring 2026 cycle who has experience and interest in analytical technologies including HPLC, LC-MS, and capillary electrophoresis (CE) to join the analytical development (AD) team. The successful candidate will be able to participate in the development of separation-based analytical methods for the Prime Editor delivery platform and work cross-functionally to advance the Prime pipeline. There will be opportunities to participate in other cross-functional projects that are crucial to the success of in vivo and ex vivo gene editing therapeutic drug development. Primary Responsibilities: Participate in separation-based method (HPLC, LC-MS, CE) development to assess lipid nanoparticle (LNP) drug products and their components. Assist senior-level scientists with buffer preparation, maintenance of instruments, and developing up-to-date analytical methods that help to increase in-process analytics capacity. Maintain detailed and accurate records of experimental data, protocols, and conclusions in an electronic notebook meeting the cGMP requirement Data analysis, interpretation, and presentation within the team. Qualifications: Currently enrolled in a B.S. or M.S. program in biochemistry, chemistry, chemical engineering, pharmaceutical science, or a related field. Basic knowledge of separation sciences and technologies. Ability to handle multiple projects in a fast-paced environment. Excellent troubleshooting and communication skills. Ability to work independently and within a team. Skilled in documenting findings and activities in comprehensive reports and ensuring proper inventory of materials and analytical equipment. Preferred Qualifications: Hands-on experience with LC-MS, CE, and/or cell culture is preferred. Previous co-op experience in the biotechnology industry. Independently motivated, detail-oriented, and excellent problem-solving abilities. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Analytical Development, LNP Drug Product

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 cycle to join the analytical development (AD) team. The candidate will gain valuable hands-on experience with laboratory techniques such as HPLC, collaborate cross-functionally with process development and quality control teams, and assist in the development of novel separation-based methods to solve complex analytical challenges and advance the pipeline. There will be also many valuable opportunities to learn about the scientific and regulatory requirements of in vivo and ex vivo gene editing therapeutic drug development and participate in projects that are crucial to the success of Prime Medicine. Primary Responsibilities: Perform a variety of assays to support companywide analytical needs for the analysis of drug substance components such as mRNA and guide RNA, and drug products such as LNP Under guidance, execute method development with separation-based methods to characterize drug substance and drug product Document experimental data meeting analytical development requirements in electronic notebooks and present findings at team meetings Effectively communicate with team members and other groups including process development, quality control, and laboratory operations Qualifications: B.S. or M.S. candidate in biochemistry, chemistry, chemical engineering, or a related field Basic knowledge of separation sciences and technologies, with an understanding of the fundamental principles behind biological and chemical techniques Ability to work independently and collaboratively as needed Excellent organization, documentation, and communication skills, with the aptitude to handle multiple projects in a fast-paced environment Skilled in writing comprehensive reports of laboratory activities and ensuring proper inventory of consumables, reagents, and analytical equipment Independently motivated and detail-oriented, with the ability to identify and solve technical issues Preferred Qualifications: Hands-on experience with separation-based analytical techniques such as liquid chromatography or electrophoresis Experience working in process development, analytical development, and/or quality control groups Experience working in a GxP environment Understanding of gene therapy within the biotechnology industry What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Analytical Development, mRNA Drug Substance

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a Spring 2026 co-op with a background in cell and molecular biology to join our Immunology team. This role provides a unique opportunity to work hands-on in a collaborative, fast-paced environment contributing to screening and validation of Prime Editing strategies across our immune-related indications. As a part of this role, you will gain valuable technical skills in cell and molecular biology while developing a deep understanding of immune cell biology, gene editing technology, and CAR-T cell therapy applications. The position will involve work on human immune cells, contributing to innovative research with potential therapeutic applications. We are looking for curious problem-solvers who thrive in a collaborative team environment and are passionate about advancing gene editing technologies for the treatment of human diseases. Primary Responsibilities: Cell Culture &amp; Functional Assays Perform primary human cell culture using aseptic technique Conduct program-specific cell-based functional assays, including flow cytometry Process in vivo samples for downstream analysis Molecular Biology &amp; Gene Editing Extract genomic DNA, perform digital PCR (dPCR), and prepare samples for next-generation DNA sequencing Assist in Prime Editing experiments and downstream molecular analysis Data Analysis &amp; Collaboration: Design and plan experiments with scientific rigor Analyze and interpret data, contributing to team discussions Document results in an ELN, and present findings in team meetings Qualifications: B.S. candidate in Cell &amp; Molecular Biology or a related major Basic understanding of cell and molecular biology Strong teamwork and communication skills Scientific curiosity, attention to detail, and excellent record-keeping skills Passionate about human disease research and motivated to help patients Preferred Qualifications: Hands-on experience with aseptic technique and cell culture Experience with basic molecular biology techniques (e.g., DNA extraction, PCR) Familiarity with flow cytometry or other immune-based assays What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: CAR-T Immunology

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in Biology and/or Health-related sciences to join the Clinical Development team. The Prime Medicine clinical development team is a tight knit, closely collaborative, highly creative group working to make the promise of Prime Editing a reality for patients with severe genetic diseases.&nbsp; The qualified candidate will be highly motivated, organized and collegial.&nbsp; The candidate will be involved in the process of operationalizing clinical trials of gene therapy for patients with genetic diseases. Primary Responsibilities: Learning from and assisting the operations team in managing clinical trials Participate in internal and external cross-functional study meetings; assist with meeting preparation, scheduling, and meeting minute taking and review Communicate with study sites to assist with patient visit scheduling, ensuring necessary study materials are delivered on time, patient sample tracking, and ensuring data entry is on-track for study deliverables Assist with maintaining study files, updating study materials (patient brochures, Informed Consent Forms, study manuals), and tracking of study deliverables and activities Qualifications: B.S or B.A. candidate for Biology or a Health sciences field, or similar Excellent analytical and written and oral communication skills Ability to work independently and as part of a team Comfort with basic statistical concepts What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Clinical Trials Operations

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester to work in a cross-functional LNP formulation and process development team. The candidate will work with formulation scientists, process development engineers, and chemical engineers to optimize mRNA and LNP formulation and processes related to the manufacture of LNPs. The candidate will gain hands-on experience with various LNP formulation techniques and processes, analytical and biophysical characterization, and play a critical role in solving challenging problems associated with LNP formulation and process development.&nbsp;&nbsp;&nbsp;&nbsp; We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being. Primary Responsibilities: Collaborate with the LNP formulation and process development team, and cross-functional teams to execute experiments supporting Prime Medicine goals Execute experiments to optimize and understand the robustness of LNP formulations and related processes Perform analytical testing for assessing LNP formulations and payload quality as it relates to critical process parameters Effectively communicate results to internal and external meetings, and present the final summary to the team Document and manage all experimental planning and progress in electronic lab notebook in an organized manner, providing statistical analysis and troubleshooting where appropriate. Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies. Qualifications: B.S./M.S. candidate in Chemical Engineering, Chemistry, Bioengineering or Biochemistry Prior wet lab experience with processes and methods of making and testing LNPs is preferred. Prior Co-Op experience(s) is preferred. Knowledge of mixing techniques, tangential flow filtration, and characterization techniques (DLS, plate based assays, HPLC) for LNPs Familiarity with DOE is a plus Excellent written and verbal communication skills. Curious, ability to work independently or collaboratively as needed Self-motivated, detail-oriented with strong critical thinking skills and excel at identifying and solving problems. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: LNP Process Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in Biology, Health-related sciences or Medical Writing to join the Clinical Development team. The Prime Medicine clinical development team is a tight-knit, collaborative, highly creative group working to make the promise of Prime Editing a reality for patients with severe genetic diseases.&nbsp; The qualified candidate will be highly motivated, articulate, analytical and collegial.&nbsp; The candidate will be involved in the development of critical clinical documents for gene therapy trials, such as clinical study protocols and Investigator Brochures and provide support to clinical trial design and development strategies.&nbsp;&nbsp; Primary Responsibilities: Support critical writing activities and content creation under the Director of Medical Writing, working cross-functionally to develop and produce high-quality deliverables such as clinical study protocols, Investigator Brochures, study reports, and IND/CTA documents In partnership with the team, critically analyze and interpret non-clinical and clinical data (internal and external) to develop content, conclusions and messaging. As needed, perform literature and scientific database searches in support of analyses and development of background summaries.&nbsp; Assist with developing formats, templates, processes and standards, style guides, workflow and operating procedures. Perform document QC and document formatting as requested; support medical writing SOP development and infrastructure build. As needed, support the various clinical functions (clinical operations, clinical science) for ongoing clinical trial execution. Qualifications: M.S, B.S or B.A. candidate for Biology, Statistics or a Health sciences field, or similar Excellent analytical and written and oral communication skills; demonstrated technical writing capabilities and desire to learn more Strong skills with various document software solutions and cloud programs for document creation (e.g., Microsoft Word, Office, Adobe, Sharepoint etc.) as well as familiarity with AI writing support programs and data visualization (e.g., Spotfire, etc.). Attention to detail and thoroughness related to processes, consistency, grammar, syntax, and scientific accuracy Ability to work, communicate transparently and collaborate with colleagues and external stakeholders as a team-player in a dynamic environment Preferred Qualifications: Course work in medical sciences, and/or familiarity with medical terminology and writing Basic understanding of cellular and molecular biology underlying gene therapy What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Medical Writing & Clinical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in biological or chemical techniques to join the Analytical Development and QC team. The candidate will learn cutting-edge technology in the field of gene and cell therapy, obtain hands-on experience with a broad range of analytical techniques, gain understanding in the scientific and regulatory requirements for phase appropriate analytical testing, and play a key role in solving complex technical challenges related to our prime editing strategy. This is a unique position with the opportunity to contribute directly to the advancement of prime editing programs toward the clinic. We want curious problem solvers who enjoy working on exciting projects, working within a team, and are passionate about developing genetic editing technologies to better human health and well-being. Primary Responsibilities: Support product development sample analyses, in-process, release and stability testing for: LNP-based drug products Prime editing component RNAs Participate in stability and reference standard programs, including protocol/report preparation, data compilation, and trend analysis, etc. Assist with sample management Conduct clean room lab environmental monitoring for GMP manufacturing suites Document and communicate experimental data in electronic notebooks per cGMP requirements Collaborate with teammates across the organization and program teams to support the product and method development, method qualification. Contribute to laboratory functionality, safety, and QC process optimization Flexibility to support taking on new projects and troubleshooting as needs arise and priorities are dynamic&nbsp; Identify opportunities for assay optimization, process improvements, and automation Qualifications: Currently enrolled in B.S./M.S. program in Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, Chemistry, Chemical Engineering, pharmacology, or a related field Completion of foundational biology, biochemistry, microbiology, or chemistry coursework with a laboratory component Ability to work both independently and collaboratively Flexibility in taking on new projects and troubleshooting as needs arise Self-motivated, detail-oriented with strong attention to problem-solving ability, and organizational skills Excellent verbal and written communication skills Eagerness to learn GLP/GMP practices and new analytical techniques Comfortable engaging in cross-functional teamwork and communication Ability to handle multiple projects in a fast-paced environment. Preferred Qualifications: Understanding of fundamental principles behind biological, microbiology, or chemical techniques, such as UV-vis, HPLC, UPLC, LC-MS, PCR/qPCR/ddPCR, potency assay, CFU identification and counting, etc. Hand-on experience with biological or chemical analytical techniques, such as sample extraction, preparation, dilution, and analysis are preferred Knowledge and/or experience in the field of gene and cell therapy, or willingness to learn Previous intern or co-op experience in biotechnology industry What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Quality Control

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a Co-op student for the Spring 2026 semester with a strong background in chemistry or biochemistry to join our guide RNA chemistry team. The selected candidate will contribute to the synthesis, purification, and analysis of oligonucleotides. This position provides hands-on experience with nucleic acid techniques, oligonucleotide characterization, data documentation, and opportunities to present findings in team meetings. We welcome curious, collaborative problem solvers who are passionate about advancing gene-editing technologies to improve human health. Key Responsibilities: Perform solid-phase synthesis of oligonucleotides using automated DNA/RNA synthesizers such as the Mermade12. Support purification and analysis of oligonucleotides with HPLC, UPLC, and LCMS. Prepare buffers and manage inventories of chemicals, reagents, and consumables. Assist with maintenance and troubleshooting of laboratory equipment, including synthesizers, speedvacs, lyophilizers, and HPLC systems. Maintain accurate electronic laboratory notebooks (ELNs), analyze and present data, and uphold safe laboratory practices. Coordinate with scientists to maintain an oligonucleotide inventory for the final released guide RNA Qualifications: Current B.S. candidate in Chemistry, Biochemistry, or a related field; basic knowledge of organic chemistry preferred. Prior experience working in a chemistry or biochemistry laboratory. Strong organizational skills with the ability to prioritize and meet deadlines in a fast-paced environment. Proficiency with common computer applications (Excel, Word, PowerPoint). Excellent troubleshooting and communication skills. Ability to work independently as well as collaboratively in a team. Preferred Qualifications: Exposure to nucleic acid chemistry through coursework or laboratory experience. Familiarity with analytical techniques such as HPLC, UPLC, or LCMS gained through academic labs or internships. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Small-Scale Guide RNA Chemistry

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking a Scientist/Senior Scientist with expertise in lipid nanoparticle (LNP) formulation and application of LNPs to mouse models to join our LNP Discovery team focused on developing non-viral delivery systems for cystic fibrosis therapies. This role involves designing and characterizing LNPs for in vivo delivery of Prime Editor RNA molecules, with hands-on in vivo work in pulmonary delivery studies. This role offers a unique opportunity to contribute across the full spectrum of LNP development, from formulation to in vivo delivery, within a collaborative, interdisciplinary cross-functional program team. We are looking for curious problem solvers who enjoy working on fast-paced, exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.&nbsp; The ideal candidate will be onsite 5 days a week in Cambridge, MA.&nbsp; Primary Responsibilities: Design and formulate LNPs using microfluidics; characterize using DLS, zeta potential, pKa, and Ribogreen assays. Execute and support&nbsp;in vivo studies focused on pulmonary delivery of LNP formulations including intratracheal delivery in preclinical models. Collaborate with internal teams on study design, execution, data collection, and interpretation. Support downstream analyses using flow cytometry and molecular biology techniques. Collaborate cross-functionally to integrate in vivo findings into delivery platform development. Present data in written reports and oral presentations. Qualifications: PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 0-2 years of relevant experience (or BS+8, MS+6). Experience with lipid nanoparticle (LNP) formulation, QC, and characterization techniques Hands-on experience with mouse handling, dosing, and tissue collection; intratracheal delivery (e.g., broncoscope) strongly preferred. Familiarity/experience with molecular biology techniques (e.g., qPCR, DNA sequencing, mammalian cel culture, and flow cytometry preferred. Strong organizational and critical thinking skills, attention to detail, and ability to work both independently and as part of a collaborative team. Excellent communication and interpersonal skills to thrive in a cross-functional setting. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Scientist/Senior Scientist, LNP Discovery

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 cycle with knowledge in cell and molecular biology to join the Immunobiology team. The qualified candidate will work hands-on with a highly collaborative, fast-paced project team to support Prime Editor selection by understanding the associated immunobiology. In this position, you will learn cell and molecular biology skills and develop a deep understanding of gene editing and immunology. Primary Responsibilities: Processing tissues into single cell suspensions for use immunobiology assays Aseptic culture of primary and immortalized mouse and human cells Setting up, performing, and collecting and analyzing data for in vivo, ex vivo, and in vitro immunogenicity assays Preparing cell samples for flow cytometry assays Data analysis, interpretation, and presentations within the team Qualifications: B.S. candidate in Cell &amp; Molecular Biology or related discipline Basic knowledge of molecular biology, cell biology and biochemistry Excellent troubleshooting and communication skills Ability to work independently and within a team Preferred Qualifications: Hands-on experience with aseptic cell culture of mammalian cells Experience with tissue dissociation Experience with flow cytometry Familiarity with Excel and PowerPoint for data analysis Independently motivated, detail-oriented, and excellent problem-solving abilities What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Immunobiology Assay Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in cellular-based studies to join the Lung Biology team. The candidate will be involved in supporting critical efforts in developing prime editing therapies for Cystic Fibrosis patients. This role will focus on supporting preclinical and in vitro studies with an emphasis on flow cytometry, tissue processing, and advanced cell culture systems such as air–liquid interface (ALI) cultures. The successful candidate will thrive in a fast-paced research program and will enjoy working with colleagues within and across teams from multi-disciplinary backgrounds. Primary Responsibilities: Keen interest in learning and performing the downstream analysis of in vivo studies, including tissue sample preparation, in vitro assays (PCR and Next-gen sequencing) and data analysis Set up air–liquid cultures of human bronchial epithelial cells and maintain them throughout the experimental period Plan and execute in vitro assays to evaluate gene editing activity in relevant primary cell models Follow protocols, standard operating procedures, execute assigned tasks and maintain ELN. Share responsibility in lab reagent inventory and maintaining equipment. Work and collaborate cross-functionally with colleagues. Collect, analyze and present data in team meetings. Qualifications: Bachelors/Masters candidate in Biology-related major Direct experience performing routine wet lab procedures and experiments Hands on experience with sterile techniques and culturing of mammalian cell culture including primary cells Experience with tissue sample preparation and immunostaining assays (flow cytometry, FACS, ICC/IHC) is a plus Preferred Qualifications: Flow cytometry/FACS experience, including sample preparation and data analysis In vitro molecular assays such as PCR/RT-qPCR Gene editing technologies and viral and/or non-viral delivery What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Lung Biology

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a Spring 2026 co-op with interest in large RNA molecule in-process analytics and purification to join the Chemistry team. The candidate will be involved in routine laboratory activities, including recording and taking UV absorbance measurements with NanoDrop, supporting purification, sample analysis by UPLC &amp; mass spectrometer (MS), and endotoxin testing of synthetic guide RNA. The candidate will learn a variety of in-process analytical techniques, gain proficiency in oligonucleotide characterization, support data generation and documentation, and present results at weekly team meetings. We welcome curious problem solvers who enjoy collaborative projects and are passionate about developing gene-editing technologies to improve human health and well-being.&nbsp; Key Responsibilities: Support characterization and purification of Prime’s long guide RNA (gRNA) using various laboratory techniques (e.g., ÄKTA purifier, UPLC, LC-MS, NanoDrop, endotoxin assays) Integrate chromatograms for gRNA crude, fraction, and final samples using Prime’s SOPs to quantify full-length product purity and tabulate the data in the team’s electronic lab notebook &nbsp; Learn &amp; contribute to mass analysis of gRNA to identify molecular weight of the full-length product and related impurities Assist senior scientists with buffer preparation, instrument maintenance, and development of up-to-date analytical methods to help increase in-process analytical capacity Oversee stock of critical reagents for buffer preparation to support purification and analytics Coordinate with scientists to manage inventory of the final released materials&nbsp; Required Qualifications:&nbsp; B.S. or M.S. candidate in Chemistry, Biochemistry, or related subjects; basic knowledge of organic chemistry preferred Prior completion of general chemistry and lab courses Excellent written and oral communication skills, strong organizational skills, ability to multi-task, and capacity to work independently or as part of a team &nbsp; A passion for learning and contributing across multiple facets of a program&nbsp; Preferred Qualifications: Relevant internship/Co-op experience Completion of analytical chemistry lecture and lab courses Familiarity working in a chemistry laboratory and experience with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure&nbsp; What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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