Lexeo Therapeutics is a leading biotechnology company specializing in the development of novel gene therapies for rare genetic diseases. Leveraging cutting-edge research and innovative technologies, Lexeo is dedicated to transforming the treatment landscape for patients with unmet medical needs.

<div>Role Summary</div><div><br></div><div>The Patient Engagement Manager position is a contract part-time opportunity for an individual to impactfully contribute to ensuring that the patient voice is incorporated into Lexeo program development and key initiatives.&nbsp; Areas of focus include Friedreich ataxia cardiomyopathy (FA-CM) and Plakophilin-2 arrhythmogenic cardiomyopathy (PKP2-ACM) programs. We seek candidates with the desire to make a difference for patient communities and to contribute cross-functionally across Lexeo.&nbsp;&nbsp;</div><div><br></div><div>As a member of the Medical Affairs team, this key role serves as a liaison among patients, families, advocates, the community, and Lexeo. The Patient Engagement Manager supports Lexeo’s role as a trusted partner to rare disease communities and leader in cutting-edge science by identifying unmet needs in patient communities, developing patient materials and external communications, and by representing Lexeo at patient community events.&nbsp; &nbsp;</div><div><br></div><div>This individual will be part of a team shaping the therapeutic area landscape for gene therapy launch readiness and joining Lexeo during an expansion phase and an exciting time, offering an opportunity for professional development and advancement.&nbsp;&nbsp;</div><div><br></div><div>Desired Candidate Profile</div><div><br></div><div>In addition to the required qualifications listed below for this role, we are seeking a team member who is highly motivated and compassionate with a proactive approach to their work. An individual who thinks outside the box, is solution-driven, open and adaptable to change, and wants to meaningfully contribute to shaping Patient Engagement at Lexeo will thrive in this role!&nbsp;</div><div><br></div><div>We are currently seeking part-time support up to 25 hours per week, with the ability to eventually increase to 40 hours per week.</div><div><br></div><div>If this sounds like you, we welcome you to apply!</div><div><br></div><div>An individual located in the Eastern time zone or willing to work Eastern time zone hours is preferred. Travel will be required to attend congresses and meetings pertinent to the role and to the NYHQ Lexeo office as necessary.</div>

Patient Engagement Manager (Part-time)

<div>Role Summary&nbsp;</div><div><br></div><div>The Senior Clinical Trial Manager (Sr. CTM), in collaboration with the clinical operations program leader, will define the clinical operations strategy and be responsible for country and global execution of complex clinical trials end-to-end consistent with the clinical plan. The Sr. CTM will be responsible for partnering with internal and external business functions and vendors throughout the life cycle of one or more clinical study(ies) in accordance with company SOPs, ICH/GCP, and all applicable local regulations. Candidates for this role must champion a culture of quality and continuous process improvement.&nbsp;</div>

Senior Clinical Trial Manager

<div>Role Summary&nbsp;</div><div><br></div><div>The Senior Clinical Trial Associate (SCTA) is a key position within LEXEO. Working closely with the Clinical Operations study lead (e.g. Director/Sr Director), the SCTA is responsible for supporting and overseeing the management of the day-to-day operational activities of the clinical study. The SCTA provides support to ensure successful execution of LEXEO’s clinical programs i.e. clinical trial activities and deliverables meet study and program objectives by partnering with internal and external business functions/vendors through the entire life cycle of the study (Plan/ Prepare, Initiate, Execution Close out), in accordance with the appropriate quality standards including ICH/GCP and applicable regulations.&nbsp;</div>

Senior Clinical Trial Associate

<div>Role Summary&nbsp;</div><div><br></div><div>The Associate Director, Clinical Trial Management (AD, CTM), in collaboration with the clinical operations program leader, will define the clinical operations strategy and be responsible for country and global execution of complex clinical trials end-to-end consistent with the clinical plan. The AD, CTM will be responsible for partnering with internal and external business functions and vendors throughout the life cycle of one or more clinical study(ies) in accordance with company SOPs, ICH/GCP, and all applicable local regulations. Candidates for this role must champion a culture of quality and continuous process improvement.&nbsp;</div>

Associate Director, Clinical Trial Management

<div>Role Summary&nbsp;</div><div><br></div><div>We are seeking a talented, dedicated, passionate and motivated individual with experience in the design and execution of pre-clinical proof-of-concept in vitro and in vivo studies of genetic medicines to join our team as Scientist I/II. The ideal candidate will have a robust background in basic and translational research and be proficient in planning and executing in vitro and in vivo pre-clinical efficacy studies. They will also be capable of managing projects, fostering collaborations with Key Opinion Leaders (KOLs) and overseeing partnerships with vendors and academic partners for pre-clinical studies. This is a highly collaborative role where the successful candidate will join a multi-disciplinary team focused on developing the next generation of cardiac genetic medicines</div>

Scientist I/II, Pre-Clinical

<div>Role Summary&nbsp;</div><div><br></div><div>The Clinical Supply (Senior) Manager/Associate Director supports the cross-functional working team and independently plans and organizes tasks to meet specified objectives and timelines. This role manages supply planning and delivery of development products to clinic by supporting clinical supply inventory management, clinical supply packaging, labelling, interactive web response system (IWRS), distribution, and logistics planning. The Clinical Supply (Senior) Manager/Associate Director is responsible for clinical supply budget and tracking in addition to managing and executing the clinical supply chain for current and future clinical study programs at all development levels.&nbsp; This individual contributor role has a strong focus on late-stage program development and commercial launch readiness.&nbsp;&nbsp;</div><div>&nbsp;</div><div>The Clinical Supply (Senior) Manager/Associate Director also has oversight of vendors supporting Clinical Development Manufacturing Organization (CDMO), Secondary Packaging and Distribution, Comparator Sourcing.&nbsp;</div><div><br></div>

Clinical Supply (Senior) Manager/Associate Director

<div>Role Summary&nbsp;</div><div><br></div><div>The Director, Corporate Finance will play an integral role in a critical function directly supporting Lexeo’s mission. The candidate will work closely with the CFO and Controlling team to oversee all aspects of financial planning and analysis as well as capital allocation modeling related to Lexeo’s operations. The candidate must have proven ability to facilitate management dialogue and decision making through fact-based analysis and evaluation of alternatives. The role will support operational aspects, financial close, analysis, budgeting and forecasting at the program and department level. The individual will be responsible for ongoing financial management of the business and will provide the organization with decision support analysis. Additionally, the individual will support both capital markets activities and strategic financial analysis, including capital expenditures and cash forecasting. The individual will play an integral role in enabling operational success of the company’s strategic priorities and will partner across the organization to ensure transparency on financial initiatives in support of Lexeo’s objectives.&nbsp;&nbsp;</div><div><br></div><div>The successful candidate will leverage prior pharmaceutical / biotech industry experience, and a track record in finance to enable a culture of excellence and financial rigor. This individual is a key member of the team responsible for ensuring sufficient resource planning to meet corporate objectives with financial discipline and acts as a key advisor to the business teams with an ability to model complex operating scenarios.&nbsp;&nbsp;</div><div><br></div><div>We welcome applications from candidates located across the Northeast and Mid-Atlantic.</div>

Director, Corporate Finance

<p>Role Summary&nbsp;</p> <p>The Senior Director, Regulatory Strategy will provide global regulatory leadership for AAV gene therapy development programs with an emphasis on early-stage clinical development. This role is responsible for defining and executing integrated regulatory strategies that align with corporate objectives, development timelines, and evolving global regulatory expectations for gene therapy products.&nbsp;</p> <p>The ideal candidate will have deep experience leading global regulatory programs and extensive interaction with FDA, EMA, and other major health authorities. Strong preference will be given to candidates who also have regulatory CMC experience that could fill a dual role leading regulatory CMC.&nbsp;</p> <p>&nbsp;</p>

Senior Director, Regulatory Strategy

<div> <div><span data-contrast="none">The&nbsp;Manager, IT &amp; Cybersecurity will&nbsp;lead day-to-day corporate IT operations and cybersecurity execution, ensuring reliable, secure, and scalable technology services for the business. Reporting to the&nbsp;CFO&nbsp;this role manages operational priorities, drives continuous improvement, and partners across functions to align technology support with organizational needs.</span><span data-ccp-props="{}">&nbsp;</span></div> <div>&nbsp;</div> <div><span data-contrast="none">This individual will work closely with the Managed Service Provider (MSP), oversee end‑user computing tools including M365, laptops, AV systems, and security infrastructure, and serve as a trusted partner to teams across&nbsp;Lexeo.&nbsp;The ideal candidate thrives in a fast‑paced, growing biotechnology environment and is equally comfortable troubleshooting immediate issues and implementing process improvements, including the responsible use of AI to&nbsp;optimize&nbsp;ticket triage/knowledge management and accelerate issue resolution,&nbsp;that support future growth.</span><span data-ccp-props="{}">&nbsp;</span></div> </div>

Manager, IT and Cybersecurity

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:257}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">The&nbsp;Associate&nbsp;Director, Medical Writing will&nbsp;support&nbsp;the Medical Writing function at&nbsp;Lexeo, working cross-functionally to generate and&nbsp;manage&nbsp;the development of clinical and regulatory documents. This role will also take a lead in&nbsp;implementing&nbsp;artificial&nbsp;intelligence (AI)&nbsp;tools to drive optimization and&nbsp;efficiency&nbsp;in all aspects of regulatory&nbsp;and medical&nbsp;writing.&nbsp;This role will&nbsp;be responsible for&nbsp;the planning, development, and oversight of study and program level documents with a focus on accuracy, quality, and compliance. Additionally, the role will manage medical writing&nbsp;and regulatory operations&nbsp;resources, including vendors and partners, and contribute to process improvement initiatives.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:257}">&nbsp;</span></p> </div> </div>

Associate Director, Medical Writing and AI Implementation

<div> <p>Role Summary&nbsp;</p> <p>You will lead and manage biostatistical activities across a complex portfolio of gene therapy studies and other projects. You will collaborate with cross-functional partners to meet clinical development project deliverables and timelines. This may include, but is not limited to, providing statistical consultation on clinical development plans, clinical trial design and clinical study endpoints, calculating sample size, authoring statistical analysis plans, and providing biostatistical input into clinical development plans, scientific publications and presentations, and regulatory filings. &nbsp;</p> <p>You will be responsible for the analysis of interim and final data sets and will oversee data and programming deliverables accountable by the CRO.&nbsp;</p> <p>A&nbsp;remote working model&nbsp;may be considered for exceptional candidates.</p> </div>

Director, Clinical Statistician

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:259}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">Lexeo&nbsp;is at an inflection point where AI and advanced analytics can materially accelerate decision-making across discovery, development, and operational execution. This Sr. Director will set direction and deliver applied AI/ML solutions across internal workflows and externally facing outputs,&nbsp;ranging from R&amp;D insights to partner-ready analyses,&nbsp;while partnering closely with scientific teams and, when needed, external vendors/partners to solve real problems. This role is intentionally hands-on and outcome-driven: a leader who can build,&nbsp;validate, and operationalize models using real-world biopharma data&nbsp;to&nbsp;raise the signal-to-noise ratio in small or&nbsp;unstructured&nbsp;datasets (including synthetic control arm approaches where&nbsp;appropriate).&nbsp;</span></p> </div> </div>

Senior Director, AI and Data Science (Drug Discovery and R&D Enablement)

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{&quot;335557856&quot;:16777215,&quot;335559739&quot;:240}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">Reporting to Lexeo’s Vice President and Corporate Controller, the Director, Accounting, will be responsible for the overall accounting and SEC reporting activities of the Company in addition to driving process improvements and support of accounting policies, procedures and internal controls. This hands-on role will oversee a team of two, execute day-to-day accounting functions, and produce high-quality SEC reporting while ensuring the application of best practices and compliance with all policies and internal controls.</span><span data-ccp-props="{&quot;335557856&quot;:16777215,&quot;335559739&quot;:240}">&nbsp;</span></p> </div> </div>

Associate Director / Director, Accounting and SEC Reporting

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">We are seeking a highly motivated Senior Accountant to join our growing team. As Senior Accountant, you will be the primary preparer of most accounting workpapers and support, reporting to the Associate Director/Director of Accounting and SEC Reporting and working closely with the AP Manager.&nbsp;</span><span data-contrast="none">This is an exciting opportunity to contribute to the advancement of&nbsp;cutting-edge&nbsp;medical treatments and shape the future of healthcare.</span><span data-ccp-props="{}">&nbsp;</span></p> <p><span data-ccp-props="{}">We welcome applications from candidates&nbsp;located&nbsp;across the Northeast&nbsp;and Mid-Atlantic.</span></p> </div> </div>

Senior Accountant

<div> <p>Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of rare cardiovascular disease programs focused on Friedreich’s ataxia (FA) cardiomyopathy and arrhythmogenic cardiomyopathy (ACM).</p> </div>

Program & Portfolio Strategy Intern (Graduate Level)

<div> <p>Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.&nbsp;&nbsp;</p> </div>

AI/ML Clinical Data Science Intern

<div><span data-contrast="none">LEXEO Therapeutics is&nbsp;seeking&nbsp;a detail-oriented and proactive Procurement Specialist to support our growing clinical-stage gene therapy organization. This role will be instrumental in managing end-to-end procurement operations, ensuring that goods and services are sourced, documented, and delivered efficiently to meet the needs of our R&amp;D and G&amp;A teams. The ideal candidate will thrive in a dynamic, fast-paced biotech environment—balancing process discipline with flexibility—and will play a key role in strengthening&nbsp;Lexeo’s&nbsp;procurement infrastructure as we advance a&nbsp;cutting-edge&nbsp;pipeline addressing genetically defined cardiovascular and CNS diseases. This is an exciting opportunity to contribute to a mission-driven company pioneering transformative genetic medicines.</span><span data-ccp-props="{}">&nbsp;</span></div>

Procurement Specialist (Contract Role)

<div> <div> <p>Role Summary</p> </div> <div> <p><span data-contrast="auto">We are looking for a talented and highly motivated contract Lab Operations Associate Scientist/Scientist I to join the Lexeo Team in NYC to support the operations within our gene therapy laboratory.</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">You will be expected to support the daily operations of the laboratory, ensuring that workflows run smoothly, safely, and efficiently. This role reports to the Lab Manager to oversee equipment, procure supplies, manage shipments, and ensure compliance with safety standards. The ideal candidate is organized, detail-</span><span data-contrast="auto">oriented, and comfortable balancing administrative responsibilities with hands</span>‑<span data-contrast="auto">on lab support.&nbsp;&nbsp;The nature of the role will require in-person work.</span><span data-ccp-props="{}">&nbsp;</span></p> </div> </div>

Lab Operations Associate Scientist/Scientist I (Contract)

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">Lexeo is seeking an experienced and motivated </span><span data-contrast="auto">clinical development&nbsp;leader to advance late-stage development programs&nbsp;as a key member of our development team. This individual will report to the&nbsp;Vice President, Clinical Development&nbsp;and will provide strategic and hands-on leadership across clinical strategy, study execution, and cross-functional integration to deliver high-quality evidence to support regulatory interactions and submissions (e.g., BLA). This role requires strong scientific and operational judgment and the ability to build effective partnerships with internal stakeholders and external collaborators.</span><span data-ccp-props="{}">&nbsp;</span></p> </div> </div>

Senior Director, Clinical Development

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="none">The Clinical Trial Manager (CTM) or Senior Clinical Trial Manager (Sr. CTM) leads the execution of global clinical studies from startup through close-out. The CTM/Sr. CTM partners closely with cross-functional teams and external vendors to deliver high-quality clinical trials on time and within budget while ensuring compliance with regulatory standards. The CTM will independently manage study execution, while the Sr. CTM will lead more complex programs with broader strategic and cross-functional responsibilities.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}">&nbsp;</span></p> </div> </div>

Clinical Trial Manager/Senior Clinical Trial Manager

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">Lexeo&nbsp;is&nbsp;seeking&nbsp;an experienced and motivated professional to lead and build our Clinical Operations function as a key member of our development team. This individual will report to the Chief Medical Officer and will ensure that studies are completed on time and within budget&nbsp;in accordance with&nbsp;corporate&nbsp;objectives. This is a hands-on role and will be&nbsp;required&nbsp;to build excellent working relationships with various internal and external groups.</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">If you enjoy being a part of a growing team and an entrepreneurial environment in which your work will have a meaningful impact on clinical trial progress for novel gene therapies, we want to hear from you!</span><span data-ccp-props="{}">&nbsp;</span></p> </div> </div>

Vice President, Clinical Operations

<div> <div> <p><span data-contrast="auto">Role Summary</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">The&nbsp;Vice President,&nbsp;Medical Affairs will provide enterprise-level leadership across&nbsp;Lexeo’s&nbsp;gene therapy program.&nbsp;Reporting to the Chief Medical Officer, this role&nbsp;will set the strategic direction for Medical Affairs, overseeing scientific communications, congress strategy, external expert engagement, medical information,&nbsp;medical evidence generation&nbsp;and medical education. This individual will serve as a senior cross-functional leader and strategic partner&nbsp;to&nbsp;Clinical Development, Regulatory, and Patient Advocacy teams.</span><span data-ccp-props="{}">&nbsp;</span></p> </div> <div> <p><span data-contrast="auto">In this role, they will shape and scale the Medical Affairs function, build organizational capabilities, and drive external scientific leadership in support of&nbsp;Lexeo’s&nbsp;development and future commercialization&nbsp;objectives. The ideal candidate is a strategic, hands-on leader who thrives in a dynamic, high-growth environment and can&nbsp;influence across&nbsp;the organization and external stakeholders.</span><span data-ccp-props="{}">&nbsp;</span></p> </div> </div>

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