Cytokinetics is a biopharmaceutical company founded in 1997. Specializing in muscle biology and the potential treatment of serious diseases, Cytokinetics aims to develop innovative therapies that could transform the lives of patients. With a focus on muscle function and the biology of muscle contraction, the company is dedicated to advancing the field of muscle biology research and drug development.

cytokinetics

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.We are currently seeking a Senior Manager, Supply Chain and Technical Project Management in our Global Supply Chain &amp; Technical Operations department.&nbsp; This position is integral to the advancement of Cytokinetics’ growing portfolio of drug candidates and technology programs and will coordinate cross-functionally to ensure project deliverables are met on-time, on-budget, and with a high degree of quality. Reporting to the Director of Portfolio Management within Global Supply Chain &amp; Technical Operations, this role will be responsible for the creation, and management of timelines, and deliverables to support the technical development, validation, and commercialization of drug substances, formulated drug product and packaging using Cytokinetics internal resources and an external network of providers.&nbsp; Responsibilities Provide project management support at any stage of the drug development lifecycle (e.g., early to late-stage development, market authorization, or post-launch phases) Develop charters, integrated schedules, deliverable lists, status updates, resource requests and related communications for assigned projects and programs Maintain a positive, results-oriented work environment by building partnerships, modeling collaboration and communicating in an open, balanced and objective manner to enable a high-performing team Proactively monitor timelines, KPIs, critical path, and resources for assigned projects using appropriate tools, project management principles and practices to deliver project objectives Work cross-functionally to coordinate interdependencies with other projects. Resolve and/or escalate conflicts and issues to remove barriers to project success Leverage risk management tools and techniques to proactively identify, mitigate and manage risks throughout the project lifecycle to avoid deviations to the project goals and objectives Engage sponsors, functional senior leadership, and key stakeholders in regular and meaningful project communications (dashboards, reports, metrics, etc.) to ensure delivery of expected business outcomes Lead and/or support continuous improvement of processes and tools 10-20% Travel, as necessary according to project needs Qualifications BA/BS in Scientific, Technical, Engineering or Business discipline (advanced degree preferred) A minimum of 10 years total work experience, with at least 5 or more years relevant experience in project management within the life sciences (pharmaceutical / biotech / medical device) industry Sound technical knowledge in one or more of the following categories: Chemical Development, Formulation Development, Clinical, Manufacturing, Analytical, Packaging, Serialization, Planning, or Logistics (small molecule drug development is a plus) Outstanding project management, planning, organization, prioritization, and time management skills Ability to adapt to changing situations, and effectively manage multiple projects and priorities Ability to think creatively in order to provide non-standard solutions Strong partnering skills – ability to thoughtfully cultivate strong and highly effective working relationships with internal and/or external customers and stakeholders Strong influencing, organizational and interpersonal skills – consistently achieves targeted results without authority by leveraging expertise, business knowledge, and partnerships Project Management Professional (PMP) Certification preferred Six Sigma or other Operational Excellence related certifications is a plus#LI-HYBRID Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Senior Manager, Supply Chain & Technical Project Management

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.The Associate Director International FP&amp;A reports to the Head of International Finance and serves as an integral member of the International Finance team. The position will have a dotted-line reporting relationship to the US-based FP&amp;A team. The role serves as a key advisor to the EU Heads of Functions (Commercial, Medical Affairs, Regulatory, G&amp;A, Supply Chain, and Quality) and contributes to the organization’s development and achievement of strategic goals. This is an outstanding opportunity for a senior finance professional with operational experience and a proven track record of creative problem-solving and change management to join a high-growth, patient-centric, mission-driven organization. Duties and Responsibilities: Planning / Resource Allocation and Optimization Act as a key advisor to the Heads of Functions within the International region to drive results aligned with corporate strategy and goals. Develop and implement forward-looking financial analytics to provide insights into operations and business plans. Maintain continuous communication with the Head of Finance International and Sr. Director FP&amp;A Global Supply Chain / Tech Ops regarding critical issues. Provide day-to-day finance support for the Ireland supply chain operations site, including analysis of global manufacturing contracts, purchase orders, and headcount reporting. Support annual budget, quarterly forecast, and long-range planning processes for supply chain and operations-related cost structures. Plan, coordinate, and execute the annual budget and forecast process for all relevant functions. Prepare regular reporting packages and presentations for senior management highlighting financial performance and risks. Support long-range planning activities. Manage quarter-end and year-end accruals, consolidation, and reporting of quarterly financials. Perform monthly variance analysis between forecast, budget, and actual results, identifying key drivers and recommending corrective actions. Coordinate cross-functionally across the International region. Ensure compliance with internal controls and procedures. Participate in or lead special projects. Perform other duties as assigned by management. Team Development / Leadership Promote a culture of high performance, accountability, and continuous improvement. Lead by example and communicate effectively across functions. Qualifications: Bachelor’s degree required; MBA preferred. 8–10 years of experience in financial leadership roles, preferably in the pharmaceutical or biopharma industry. Experience directly supporting senior Commercial and Manufacturing executives. Strong knowledge of financial planning, accounting, and cost accounting. Excellent written and oral communication skills in English. Demonstrated leadership ability, team management, and interpersonal skills. Strong financial modeling, analytical, and abstract reasoning skills. Ability to operate effectively as both a tactical and strategic thinker. Experience with ERP systems (SAP, Oracle, NetSuite) and planning tools. Advanced Excel skills. #LI-HYBRIDOur employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Associate Director International FP&A

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.The Senior Accounting Manager, DACH, reporting to the Head of International Accounting, plays a pivotal role within the International Finance team. This position oversees statutory and tax compliance for the DACH region (specifically Germany and Switzerland) and ensures robust SOX and US GAAP compliance. It offers an exceptional opportunity for an experienced finance professional with hands‑on operational capabilities and demonstrated success in developing and strengthening finance organizations. Duties and Responsibilities: Statutory &amp; Financial Reporting Lead preparation and filing of statutory financial statements for all DACH legal entities under local GAAP Coordinate year-end statutory reporting and disclosures Ensure compliance with local accounting standards and regulatory requirements Manage statutory adjustments from group reporting to local GAAP Coordinate with external advisors for statutory accounts and filings Maintain statutory accounting calendars and ensure deadlines are met Partner with the External Accounting Firm Audit Management Act as primary contact for external auditors across DACH entities Manage statutory audits end-to-end, including planning, documentation, and issue resolution Coordinate internal audit requests and remediation actions Prepare audit schedules and supporting documentation Ensure timely closure of audit findings and control deficiencies Support SOX / internal control compliance (partnering with US team) VAT Responsibilities Oversee preparation and timely submission of VAT returns and related filings across all DACH entities, in coordination with internal tax teams and external advisors Ensure accuracy and completeness of VAT reporting through reconciliation of VAT accounts to the general ledger Review VAT treatment of complex transactions, cross-border supplies, and intercompany charges Support VAT audits and inquiries from tax authorities, including documentation and response coordination Monitor changes in VAT legislation and ensure accounting processes and controls remain compliant Balance Sheet Governance Own balance sheet integrity across all DACH entities Ensure timely and accurate balance sheet reconciliations for all accounts Prepare reconciliations Investigate and resolve aged or unusual reconciling items Drive continuous improvement in balance sheet control processes Compliance &amp; Regulatory Ensure EU entities operate in full compliance with US GAAP, corporate accounting policies, and SOX internal control requirements Own and maintain SOX control framework across EU entities, including documentation, control design, and operating effectiveness testing Partner closely with US Corporate Accounting, Internal Audit, and Controllership teams to support quarterly and annual SOX certifications Coordinate remediation of control deficiencies, ensuring timely resolution and sustainable process improvements Qualifications: A minimum of a BS or similar designation; CPA preferred Minimum 10 years of progressive accounting experience, including statutory reporting and financial close for multiple EU entities, preferably within a multinational environment Strong expertise in US GAAP reporting, with solid knowledge of local GAAP requirements across European jurisdictions, mainly Germany and Switzerland Proven experience managing external and internal audits, including SOX compliance, internal controls, and audit coordination with Big4 or international audit firms Demonstrated experience in balance sheet governance, reconciliations, and month-end/quarter-end close processes in a complex multi-entity structure Ability to partner effectively with US Corporate Accounting and Controllership teams, ensuring alignment with global accounting policies and reporting deadlines Advanced proficiency in Microsoft Excel, including complex formulas, pivot tables, data analysis, and financial reporting models Strong experience working with ERP systems such as Oracle, SAP, NetSuite, or similar financial systems Experience with financial consolidation and reporting tools (e.g., Oracle Hyperion or similar platforms) Solid understanding of general ledger systems, account reconciliation tools, and automated close processes Ability to analyze large financial datasets, improve reporting automation, and leverage financial systems to enhance accounting processes and internal controls Language skills: English fluent, and German preferred LI-HYBRID Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Senior Accounting Manager, DACH

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.Job purpose This role supports Cytokinetics European Countries across all functional areas and is responsible for procuring goods and services at the Country level. &nbsp;The Sr. Procurement Operations Specialist (Contract) is accountable for working with internal and external partners to optimize purchasing activities and assessing and communicating challenges, risks, opportunities, and decisions with skill and diplomacy. Responsibilities Provides oversight of externally contracted activities at the Country level; demonstrates ability to engage technically, operationally and commercially to enable Procurement activities. Solicits and analyzes requests for proposals, negotiates contracts, and ensures contract objectives are realized (savings, SLAs, etc.); ensures compliance with pricing agreements and internal policies/procedures. Performs administrative tasks including initializing purchase orders and management of document flow between various functions related to RFIs, RFPs, and contracts (e.g. MSAs, Work Orders, Change Orders, Consulting Agreements, etc.) Gains proficiency in Linksquares, responsible for input and oversight of document workflow in the legal contract system. Responsible for tracking all vendor contract requests, providing regular follow-up to ensure timely approval, and maintaining vendor documentation. Manage purchasing activities to ensure goods are within delivery, quality, compliance, and pricing parameters. Manage supplier relations and performance, including vendor selection, vendor set up, pricing negotiation, invoicing, returns/credits, and on-time delivery. Develop and implement policies and procedures related to purchasing with a goal of maximizing efficiency and optimizing workflow. Qualifications Minimum BA/BS / University Degree 7+ years of experience of supply chain / purchasing / procurement experience Experience using an ERP system (Oracle Fusion preferred) Demonstrated experience in electronic contracts management systems Ability to work effectively and efficiently with all levels of management and personnel Ability to handle multiple projects in a timely manner Strong commitment to customer service Demonstrates ability for problem-solving in collaboration with internal and external contacts Demonstrates excellent verbal, written, and interpersonal communication skills; professional manner Strong organizational and planning skills and meticulous attention to detail Able to work independently while exercising initiative, flexibility and good judgment#LI-HYBRID Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Sr. Procurement Operations Specialist (Contract)

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact. We have the flexibility to offer this position either on Sr Specialist or on Associate Director level, to be adjusted to the experience of the successful candidate. The Cardiovascular Therapeutic Area (CV-TA) Senior Specialist/Associate Director, Medical Affairs will assume a key role within the organization, will work collaboratively with other members of the Medical Affairs team in the development and execution of the Medical Affairs plan for aficamten as well as collaborate cross-functionally with the Commercial and Clinical departments in the strategic planning and life-cycle management process of our cardiovascular portfolio. The Senior Specialist/AD will provide support to internal colleagues, resolve medical issues, and provide critical input into the development of medical documents (external scientific communications, standard response letters, training materials, product materials, publications, research ideas, internal training materials, etc.) to ensure high strategic and scientific standards. Importantly, the Sr. Specialist/AD will serve as a key member of the Medical Affairs Hypertrophic Cardiomyopathy team, may represent Medical Affairs externally through presentations at advisory boards, key scientific meetings, and interactions with our key investigators. Additionally, the Sr Specialist will support strategic partnerships with key opinion leaders, academic institutions, and professional societies. Responsibilities Supports the development of aficamten, including Assists in development of strategic planning, Execution of medical launch activities, Education of healthcare practitioners and internal teams regarding the clinical profile of aficamten and its place in HCM therapy Support the Medical Affairs review of medical and promotional scientific materials related to hypertrophic cardiomyopathy and aficamten Provide day‐to‐day medical guidance while working closely with other members of the Medical Affairs team in Zug and in Europe and cross-functionally within Cytokinetics and with external business partners. Activities include: Participation in appropriate cross‐functional and cross‐company Medical and Commercial teams to inform brand strategies and tactics and represent Medical Affairs Clinical and scientific support in responding to inquiries from healthcare professionals Scientific congress/conference strategy and planning, advisory boards, publication steering committee meetings, field force training, review of medical information standard response letters, and marketing/policy related projects. Input into medical education, grant, and sponsorship review Scientific input into publication strategy for the hypertrophic cardiomyopathy therapeutic area, including review of abstracts and posters for presentation at scientific meetings and manuscripts for publication Help develop integrated evidence plan (IEP) strategy including life cycle management through leading workstreams to identify evidence gaps and establishes linkage between Medical, Research and Development (R&amp;D), HEOR to develop data generation. Support scientific and clinical priorities for an investigator sponsored study program as we near launch and support the internal review committee that adjudicates submitted research proposals. Present data at company advisory board meetings and training programs. Help identify and effectively interact with hypertrophic cardiomyopathy external experts to engage in scientific exchange to meet the needs of patients and the medical community. Qualifications PharmD/PhD/MD with prior pharmaceutical industry experience preferred (+1 year for Sr. Specialist, and more for AD level). Proven ability to work independently and as a member of an integrated, interdisciplinary team in carrying out assigned responsibilities Must be analytical and articulate in both oral and in writing skills, possess excellent presentation skills, with a demonstrated ability to communicate well with others at varying professional levels Background in academic medicine, clinical research, and familiarity with biostatistics and epidemiology highly desirable A history of clinical or research collaboration with opinion leaders in the CV-TA is preferred Familiarity with EFPIA, PhRMA code, and key regulations in the pharmaceutical industry a plus Proficiency with Microsoft Office Knowledge of other European languages beyond English highly desirable Ability to travel domestically and internationally (~20% of time) #LI-HYBRIDOur employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Senior Medical Affairs Specialist

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact. We are seeking an experienced Payroll Manager to support our growing organization. This role will be responsible for overseeing payroll operations, ensuring accuracy, compliance, and efficiency across processes while partnering closely with internal stakeholders and external providers. This is a fixed-term contract until the end of the year, with the possibility of extension. The position follows a hybrid working model, with three days per week in our Zug office. Key Responsibilities: End-to-End Payroll Operations: manage and oversee full-cycle payroll processing for EU entities, ensuring accuracy, completeness, and timely salary payments in compliance with local labor and tax regulations. Partnering with HR and BDO. Process manual payment for newly created entities. Balance Sheet Reconciliations: own payroll-related balance sheet accounts for all EU entities, including salaries payable, social security liabilities, bonus accruals, and other employee-related provisions. Payroll Accounting &amp; Accruals including PTO / Leave Accrual Management: oversee paid time off (PTO), vacation, and leave accrual calculations; ensure compliance with local labor laws and accurate financial reporting of leave liabilities. Prepare and issue monthly PTO balance report with lead team. Review payroll-related journal entries, including salary, bonus, commission, and employer tax accruals; ensure proper reconciliation to the general ledger. Equity / Stock Compensation Process Management: coordinate payroll treatment of stock-based compensation (RSUs, options, ESPP), ensuring proper taxation, reporting, and accounting in alignment with corporate policies. Close partnership with BDO and Tax department. Validation of annual certificate required for employees. Compliance &amp; Regulatory Reporting, Internal Controls &amp; SOX Compliance: ensure timely submission of payroll tax filings, social security contributions, and statutory reports in coordination with local authorities and providers. Maintain and strengthen payroll-related internal controls, support SOX documentation and testing, and ensure audit readiness for both internal and external audits. Accounting Manager responsibility for France entity, FBNL protentional (approximately 30% of time). Lead preparation and filing of statutory financial statements for France legal entities under local GAAP. Oversee preparation and timely submission of VAT returns and related filings across all France, in coordination with internal tax teams and external advisors. Own balance sheet integrity across all DACH entities. Qualifications: Minimum 10+ years of progressive experience in end-to-end payroll management, with strong expertise in multi-country or multi-state compliance, tax regulations, statutory reporting and benefits administration. Proven ability to implement, optimize and scale payroll systems and processes. Demonstrated capability to design and manage agile payroll frameworks within fast-paced, high-growth or startup-style environments, partnering closely with Finance, HR, and leadership teams. Excellent communication, stakeholder management, and leadership skills, with experience mentoring team members and building trusted cross-functional relationships in dynamic organizational cultures. Fluency in English (written and spoken) is required to effectively manage global payroll communications, documentation and stakeholder coordination. Additional proficiency in relevant regional languages (e.g. French) is strongly preferred. Clear and professional written communication skills for reporting, policy documentation, and audit-related correspondence. &nbsp; #LI-HYBRIDOur employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Payroll Manager (Contractor), 100%

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.As a subject matter expert in Medical Affairs, the Senior Director Medical Affairs UK will oversee all medical initiatives throughout the UK and contribute to the development and implementation of global medical affairs strategies. They will provide support to internal colleagues and collaborate closely with the Global &amp; European Medical Affairs teams to ensure high strategic and scientific standards by resolving medical issues and providing critical input in the development of medical documents (publications, external scientific communications, standard response letters, product materials, research ideas, internal training materials, etc.). The Medical Director, under the guidance of the VP of Medical Affairs Europe to whom s/he will be reporting (and dotted line to the UK leader), will ensure strategic partnerships with key external opinion leaders and academic institutions in the UK market, and represent Medical Affairs externally through presentations at advisory boards, key scientific meetings, and interactions with our key investigators.&nbsp; In addition, the Medical Director will work cross-functionally with other colleagues to provide expertise on varied workstreams, including pre-launch and launch activities related to late-stage assets. &nbsp; The role is hybrid twice per week in London office.&nbsp; Responsibilities Serves as an integral component of the Medical Affairs contribution to the UK launch of our late-stage cardiovascular clinical compounds, including: Implementation of the Country Plan of Action based on the Global and European Medical Affairs Plan, Execution of medical pre-launch and launch activities, Education of Cardiovascular HCPs (heart failure and hypertrophic cardiomyopathy) regarding the clinical profile of our CV compounds and their place in therapy Can speak to the mechanism of action of the compounds and their development, including Phase I-IV studies, at a detailed scientific level in a reactive conversation with key opinion leaders. Provide day‐to‐day medical guidance while working closely on joint projects with other members of the Medical Affairs team, the Countries leadership, other departments internally and our business partners. Projects may include scientific congress/conference strategy and planning, advisory boards, field force training, review of medical information standard response letters, health economics and epidemiology analyses, and marketing/policy related projects. Represent the company at Medical Congresses and ensure Medical Affairs coverage, including scientific session attendance and reporting, and information booth support. Represent the company in patient groups and associations. Provide scientific input into publication strategy and review abstracts and posters for presentation at scientific meetings and manuscripts for publication. Participate in appropriate cross‐functional and cross‐company Medical and Commercial teams in the UK to inform brand strategies and tactics and represent Medical Affairs. Liaise with Global &amp; European Medical Affairs and R&amp;D colleagues to develop and maintain timely and relevant product expertise for the region. Provide input into medical education, grant, and sponsorship review. Provide clinical and scientific support in responding to inquiries from healthcare professionals. Participate as medical reviewer in the Medical Review Committee and the Promotional Materials Review Committee Data Generation and Presentation Present data at company advisory board meetings and training programs Collaborate with R&amp;D and HEOR in data generation projects to address identified medical data gaps for the UK Help identify and effectively interact with opinion leaders to engage in scientific exchange to meet the needs of patients and the medical community. Collaborate with Market Access and the HEOR function to define research strategy and design of studies, including the generation of real-world evidence and cost-effectiveness analyses. Provide support for and collaborate with the field medical teams in the UK and support reactive material development to address healthcare professional inquiries. Upon initiation of a Phase 4 program, participate in the review and adjudication of investigator-sponsored study research proposals. Qualifications MD/MBBS with strong Medical Affairs experience. Cardiovascular experience preferred, clinical experience desirable. Position will be filled at a Director level (i.e. Director, or Senior Director) commensurate with experience. 7 years of pharmaceutical industry experience preferred. Medical Affairs experience in the UK (with particular knowledge of the Countries market) with medicine approvals and peri-launch and launch activities. Background in academic medicine, clinical research, and familiarity with study design, biostatistics and epidemiology desirable. Proven ability to work independently and as a member of an integrated, interdisciplinary team in carrying out assigned responsibilities. Must be analytical and articulate in both oral and writing skills, possess excellent presentation skills, with a demonstrated ability to communicate well with others at varying professional levels. Familiarity with relevant regulatory authorization requirements and other key local authorities in the regional pharmaceutical industry. Ability to think broadly about scientific communications and the impact on medical content. Business fluent in English. Knowledge of other European languages are a plus. Proficiency with Microsoft Office Ability to travel within the UK, across Europe, and internationally (~35% of time) &nbsp; #LI-HYBRIDOur employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Senior Medical Director, UK

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.The Director, Analytical Development &amp; CMC Compliance is a strategic technical subject matter expert (SME) supporting analytical development roadmap establishment, analytical process optimization, and continuous improvement. The position acts as a technical leader and subject matter expert (SME) in CMC analytical development strategy from tox to Phase 1 through Phase 3 to support global regulatory filings (IND, IMPD, NDA, MAA, etc.). Leads the development, qualification, and lifecycle management of analytical methods and control strategies aligned with ICH guidelines and evolving regulatory expectations. Ensures robust, compliant analytical control strategies to enable successful clinical progression, registration, and commercial success. The position works closely with Manufacturing, Process Development, Regulatory CMC, and Quality Assurance to ensure compliance with global regulatory standards (e.g., FDA, EMA, ICH) and to enable successful product approvals. Responsibilities Technical Leadership Execute analytical development strategies aligned with corporate objectives, program requirements, Analytical Target Profile (ATP) and Quality Target Product Profile (QTPP), in close collaboration with line management and GSC&amp;TO leadership. Lead establishment and maintenance of Analytical Development standards, integrating all best in industry guidelines and Health Authority regulations. Drives the design and implement robust, phase-appropriate and robust analytical approaches to enable successful clinical development and registration. Provide technical leadership and mentorship, influencing cross-functional decisions and advancing analytical and compliance excellence within CMC Analytical. Serve as a technical and regulatory subject matter expert, supporting inspections and audits and contributing to inspection readiness.2. Analytical Development Lead analytical development activities of assigned programs, characterization studies, comparability assessments, and stability strategies. Manages the development, qualification, validation, and lifecycle management of analytical methods and control strategies. Manage GMP testing for raw materials, in-process, drug substance, and drug product. Oversee development activities at external laboratories and CDMOs ensuring compliance and timeline. Lead analytical transfer activities supporting drug substance and drug product manufacturing process transfer and scale up. Serve as analytical subject matter expert in due diligence activities. Ensure timely release testing and stability testing to meet development and production timelines. Manage change control, OOS/OOT investigations, CAPA implementation, and deviation management. Ensure compliance with ICH guidelines (e.g., Q2, Q14), USP, EP, JP &nbsp;and other compendial standards. Support regulatory submissions (IND, IMPD, NDA, MAA, JNDA, etc.) including authoring/ reviewing high-quality CMC sections and lead responses to regulatory questions (RTQs). &nbsp; &nbsp; &nbsp;3. Quality &amp; Regulatory Compliance Serve as Analytical method and Quality Control SME during regulatory inspections (e.g., FDA, EMA, PMDA). Support inspection readiness and continuous improvement culture. Ensure data integrity and GMP documentation practices. &nbsp; &nbsp; &nbsp;4. Budget &amp; Resource Management Support development and execution of program budgets (capital and operational). Optimize internal vs. external testing strategies. Evaluate and implement advanced analytical technologies. Qualifications Education Ph.D. or equivalent in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related field (preferred) Experience 10+ years in pharmaceutical/biotech analytical development with demonstration of progressive technical leadership roles and global experience Demonstrated experience supporting INDs, NDAs/MAAs Demonstrated experience with stage gate development strategies. Direct experience interacting with global health authorities &nbsp;Technical Expertise Chromatography (HPLC, UPLC, GC) Mass spectrometry Stability studies and degradation pathways Method development, validation, transfer, and lifecycle management Proficient in writing technical reports and AD/QC sections of CMC regulatory documents GMP laboratory systems (Veeva, LIMS, Empower) Analytical development experience in drug substances and drug products Core Competencies Strategic thinking and enterprise leadership Strong regulatory and compliance acumen Operational excellence mindset Excellent interpersonal, communication and decision-making/influencing skills Expert knowledge of cGMP and GLP compliance and regulations and experienced in manufacturing batch record review, product specifications, stability programs and other AD/QC activities Demonstrated ability to manage external contractors to meet or exceed Company goals Risk assessment and problem-solving expertise Exceptional communication and mentorship skills#LI-HYBRID Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Director, Analytical Development & CMC Compliance

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.Job purpose As the Associate Director, External Manufacturing and Supply Operations, you are responsible for operational execution of external manufacturing and related supply activities. This is a central role within Manufacturing and External Supply Operations and requires the ability to manage multiple activities simultaneously, balancing priorities, with a strong sense of urgency, ability to work with ambiguity, and attention to detail. This position will have you collaborating with other members of Supply Chain, Quality Assurance, Regulatory Affairs, and Finance to execute and deliver endorsed global supply plans for both clinical and commercial supply. You will report to the Director, External Supply Operations. Responsibilities Build and maintain productive relationships with external contract manufacturers (CMO’s), and internal global colleagues Ensure timely and effective execution of all manufacturing and supply plans at assigned CMO’s Develop and manage production processes to support operational execution, including BOM’s, specifications, CAPA’s, change controls, master data, and artwork. Familiarity with ERP/MRP systems Support logistics, transportation and import/export activities Act as the manufacturing and supply chain representative for review and approval of documentation including but not limited to batch records, BOM’s, specifications, artwork, and change control Support product qualification activities including but not limited to reviewing/approving IQ/OQ/PQs, stability, and validation protocols; review and approve change controls Play a key role in supporting selection and onboarding of new CMOs, technical transfers, operationalizing product supply and site establishment Manage and track inventory, perform inventory reconciliations, and support month end close process. Issue purchase orders, and track invoices and budgets Maintain production schedules and track batch record execution in coordination with Quality Oversee, review, and approve as necessary revisions to manufacturing cGMP and non GMP documentation Proven risk management acumen with a continuous improvement mindset Where necessary, provide input to the manufacturer and QA for evaluation of process deviations and assist in the investigation of product complaints Build and maintain strong partnerships and provide effective communication with all internal and external stakeholders and lead discussion, problem solving efforts and process improvements to ensure that performance targets are met or exceeded Responsible for scheduling and maintaining routine business operations meetings with CMO’s Support Regulatory submissions and CMC as required Qualifications Education &amp; Core Experience BS/BA Degree in Life Science, Biology, or Engineering discipline from an accredited college or university, or equivalent desired 10+ years’ combined experience in manufacturing, outsourced operations, technical operations and/or supply chain in regulated healthcare industry, preferably within biotech/pharmaceutical industry cGMP career experience embedded in a pharmaceutical manufacturing plant is essential – with first-hand knowledge of plant operations, with the insight to assess performance, and diagnose issues directly at the source Technical background with knowledge of engineering and pharmaceutical manufacturing processes in small molecules is required, and experience in DS/API production is desirable Excellent problem-solving skills, with the ability to address complex challenges under time pressure Demonstrated expertise in risk management, with a history of successfully implementing risk mitigation strategies Hands-on investigations/RCA (OOS/OOT/deviations) and continuous improvement at external sites The ability to function in a fast-paced, high-growth, entrepreneurial environment Ability to travel domestically and internationally ~25% Position requires a strong working knowledge and understanding of both regional and international regulations by government agencies affecting the pharmaceutical industry (CFR's, EU GMP, ICH) Timely and effective communication across multiple audiences, both verbally and in writing#LI-HYBRID Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

Associate Director, External Manufacturing and Supply

Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.Job purpose We are seeking a Director of Packaging &amp; Artwork Management to lead the strategy, systems, and execution of artwork lifecycle management. Reporting to the VP of External Manufacturing, this role will build inspection-ready, scalable, and fit-for-purpose artwork capabilities, with a strong emphasis on Global market requirements. This role is accountable for establishing end-to-end artwork management, including system selection and validation, intake and workflow design, lifecycle processes, and regulatory alignment. The leader will operate in a fast-paced, resource-constrained environment, balancing compliance, speed, and efficiency while supporting global commercialization. Responsibilities Artwork Strategy &amp; Systems Define and implement a scalable global artwork strategy aligned to company growth. Lead selection, validation, and deployment of Artwork Management Systems (AMS), including: Ensure systems are GxP-compliant, right-sized, and integrated with Regulatory, Quality, and ERP platforms as appropriate. Intake, Triage &amp; Workflow Management Establish a centralized intake and prioritization model for artwork requests across products and markets. Implement governance and prioritization frameworks (launches, lifecycle changes, safety updates). Deploy tracking tools and dashboards to provide visibility into timelines, risks, and bottlenecks. Align artwork demand with regulatory submissions and manufacturing schedules. Artwork Lifecycle Management Design and implement end-to-end processes (creation, review, approval, change control). Enable efficient cross-functional workflows that minimize cycle time while ensuring compliance. Establish version control, audit trails, and documentation to support inspection readiness. Oversee mock-ups and concept artwork for regulatory and internal use. Safety &amp; Time-Critical Labeling Updates Build lean, rapid-response processes for safety-driven labeling updates. Ensure accelerated execution while maintaining full compliance. Coordinate with Regulatory, Pharmacovigilance, and Manufacturing to support timely multi-country implementation. Packaging &amp; External Manufacturing Integration Partner with External Manufacturing and CMOs to ensure artwork is production-ready. Align artwork processes with packaging operations, supply timelines, and launch readiness. Provide oversight to artwork vendors and packaging partners to ensure quality and consistency. Compliance, Quality &amp; Continuous Improvement Establish and maintain GMP-compliant SOPs, policies, and workflows. Ensure all activities are inspection-ready and aligned with global expectations. Drive improvements in cycle time, right-first-time performance, and process simplicity. Leadership &amp; Performance Management Act as the artwork and labeling SME across Regulatory, Quality, Supply Chain, and Commercial. Define and track KPIs (cycle time, approval timelines, right-first-time, on-time delivery). Manage budget and vendors with a focus on cost-effective, scalable solutions. Qualifications Required Experience Bachelor’s degree preferred 10+ years in pharmaceutical packaging, labeling, and artwork management within a GxP environment Demonstrated experience building artwork intake, triage, and tracking processes in fast-paced environments Track record of success implementing end-to-end artwork lifecycle management Proven success in managing time-critical labeling and safety updates and selecting and deploying validated AMS platforms Leadership Capabilities Proven ability to build scalable processes from the ground up Strong stakeholder management and decision-making skills Ability to simplify complexity and drive execution in resource-constrained settings#LI-HYBRID Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you. Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.&nbsp;&nbsp; Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves. Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process. Here are some ways to check for authenticity: We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com Please visit our website at: www.cytokinetics.com Cytokinetics is an Equal Opportunity Employer &nbsp;

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