Alumis, established in 2005, is a leading innovator in sustainable energy solutions. The company's cutting-edge technologies in solar power and energy storage have revolutionized the renewable energy sector, driving the transition towards a cleaner and more efficient future. Alumis continues to push boundaries with its comprehensive range of eco-friendly products and services, making significant strides in combating climate change and promoting environmental sustainability on a global scale.

<div class="content-intro">Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;</div>&nbsp;
The Role
The Medical Outcomes Liaison (MOL) is a field-based Medical Affairs professional responsible for engaging payers and healthcare decision makers (HCDMs). This role focuses on communicating the clinical and economic value of Alumis therapies to support formulary access, reimbursement, and patient outcomes. This is a critical role supporting pre-launch and launch readiness, translating clinical and HEOR evidence into meaningful value narratives for population-based stakeholders.
Key Responsibilities:
• Build and maintain relationships with payers, PBMs, and health systems
• Deliver clinical, real-world, and health economic evidence to inform access decisions
• Support payer engagement strategy, including pre-launch activities and value communication
• Contribute to HEOR and evidence generation plans, including AMCP dossier support
• Gather insights on payer needs and market dynamics to inform strategy
• Collaborate cross-functionally with Medical Affairs, HEOR, and Market Access teams
&nbsp;
Qualifications:
• Advanced degree required (PharmD, PhD, MD, MPH, or equivalent)
• 5+ years of experience in Medical Affairs, HEOR, Market Access, or related field
• Experience engaging payers or healthcare decision makers strongly preferred
• Strong understanding of HEOR, RWE, and U.S. payer landscape
• Excellent communication and stakeholder engagement skills
&nbsp;
What You Bring:
• Ability to translate complex data into clear, payer-relevant value insights
• Strong collaboration skills in a cross-functional, fast-paced environment
• Strategic mindset with a focus on value-based care and patient access
Travel:&nbsp;Up to ~50–75%
&nbsp;
Why Join Alumis
• Be part of a launch-stage biotech shaping the future of TYK2 inhibition
• Play a key role in defining the value story for a novel therapy
• Work in a highly collaborative, science-driven Medical Affairs organization
The salary range for this position is $200,00 to 265,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background.
This position is primarily remote with travel. We have 3 MOL roles (geographically dispersed) that we are working to fill.
&nbsp;
Alumis Inc. is an equal opportunity employer.
Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp;
Other benefits include:
<ul>
<li>Health insurance premiums paid at 90% for employee, 80% for dependents</li>
<li>Free access to Genentech Bus &amp; Ferry Share program</li>
<li>$100 monthly cell phone stipend</li>
<li>Unlimited PTO for Exempt employees</li>
<li>Free onsite gym and a kitchen stocked with yummy snacks and drinks!</li>
</ul>
We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Medical Outcomes Liaison

<div class="content-intro">Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;</div>&nbsp;
The MSL is a strategic, field-based, scientific expert focused on developing and maintaining collaborative relationships with Dermatology key opinion leaders (KOLs) and other healthcare professionals (HCPs). The MSL will engage with HCPs to support trial enrollment, educate on disease states and clinical trial outcomes, and inform internal strategy by gathering insights and representing the voice of KOLs and HCPs. MSLs strive to optimize patient care through KOL engagement and collaboration.
Current geographical areas of need:
· Northern California
· Southern California
· Great Plains
· Northern Texas
· Southern Texas
· Chicagoland
· Michigan
· Midwest
· Gulf South
· Florida
· S Manhattan
· New England
· Mid Atlantic
Key Responsibilities Include:
&nbsp;
· Develop and maintain collaborative relationships with KOLs in the Dermatology community.
· Utilize systems to strategically map, identify, profile and prioritize thought leaders in line with the medical strategy
· Effectively develop and manage your assigned geography with an entrepreneurial approach
· Support clinical development initiatives including site identification, trial recruitment, timely completion of study milestones, and presentation of data
· Attend and report on assigned medical conferences
· Collaborate with KOLs on medical affairs initiatives including publications, advisory boards, medical education opportunities, training, and speaker development
· Serve as scientific resource to external disease experts and internal stakeholders
· Support the medical community with up-to-date medical information, robust disease expertise, and product information
· Gather and communicate insights from HCPs to inform medical strategy
· Train internal stakeholders on key scientific and medical topics
· Maintain effective and appropriate communication among internal stakeholders while maintaining full compliance with relevant requirements
· Lead and/or contribute to Medical Affair workstreams, projects, or resource development
· Maintain accurate documentation of MSL activities
· Support commercial activities where appropriate
Requirements:
&nbsp;
· Advanced degree in scientific, clinical, or medical-related discipline (PharmD, PhD, MSN, DNP, PA-C, MPH, etc).
· At least 3 years of experience in MSL role, and must include experience as a Dermatology MSL. Launch, pre-launch, psoriasis, and/or Rheumatology experience is a plus
· Must have well-established networks and active relationships with KOLs in Dermatology and in the territory.
· Candidate must understand compliance considerations and demonstrate ability to work compliantly
· Ability and willingness to travel ~50%. Required travel to medical meetings, team meetings, and other group meetings (will require some weekends). This may vary depending on business needs
&nbsp;
Skills, Knowledge &amp; Abilities:
· Excellent oral and written communication skills
· Excellent interpersonal and engagement skills
· Energetically embraces responsibilities, demonstrates ability to achieve goals
· Demonstrates strong initiative as a flexible and proactive
· Ability to thrive in ambiguous situations
· Solution-oriented approach
· Exhibits excellent time management and ability to prioritize
· Demonstrated ability to work independently
· Experience in a start-up environment is a plus
The salary range for this position is $195,00 to 235,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background. Level depends on experience.
This position is primarily remote.
Alumis Inc. is an equal opportunity employer.
Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp;
Other benefits include:
<ul>
<li>Health insurance premiums paid at 90% for employee, 80% for dependents</li>
<li>Free access to Genentech Bus &amp; Ferry Share program</li>
<li>$100 monthly cell phone stipend</li>
<li>Unlimited PTO for Exempt employees</li>
<li>Free onsite gym and a kitchen stocked with yummy snacks and drinks!</li>
</ul>
We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Medical Science Liaison

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is hiring a Senior Director of Clinical Quality Assurance, reporting to the Executive Director, GCPQA. The role works closely with the Quality leadership and Study Execution Team members to provide ICH-GCP/GVP support for all ongoing clinical studies. This involves working closely with Clinical Operations, Clinical Development, Clinical Supply Chain, Data Management, Pharmacovigilance, Medical Affairs, Regulatory, Legal, and other teams across Alumis. The Senior Director of Clinical QA is responsible to ensure quality is embedded throughout the lifecycle of all the ongoing clinical programs through oversight, assessment and monitoring, risk assessment tools, auditing and risk mitigations. The Senior Director will lead Key Performance Indicators and Metrics to trend and track on the health of the clinical trials. The role is responsible for providing the operational quality guidance for the development teams and supporting the Executive Director of GCP Quality in building the Alumis Quality organization strategy and vision. This position requires expertise in Good Clinical and Pharmacovigilance Practices and relevant US and EU regulations. The successful candidate will drive, promote, and embed a culture of ethics, integrity, and proactive quality management. The candidate will provide guidance and leadership to ensure that the quality function maintains the standards expected by global regulatory authorities. &nbsp; ESSENTIAL DUTIES &amp; RESPONSIBILITIES Establish and maintain the GCP QA programs, policies, and procedures. Ensure ongoing clinical programs are in compliance with applicable health authority regulations and guidelines. Act as the primary GCP QA subject matter expert and point of contact for all GCP/GVP related matters and issues. Establish the study specific audit plan; perform audits and lead a team of external quality auditors as needed. Represent Quality on project teams, Health Authority Inspections, service providers and CROs operational meetings, and QA to QA meetings. Manage Quality Review Board meetings content and material. Prepare KPI and metrics. Provide quality oversight and review of key Clinical and IND/NDA enabling documents. Perform reviews of clinical trial documentation for data integrity and compliance with Good Clinical Practice guidance and regulations. Conduct root cause analysis for recurring issues. Determine the strategy for and lead the implementation of inspection readiness plans and activities. Act as the primary liaison with Health Authority and internal/external business partners. Support clinical service provider selection and qualification activities and develop periodic compliance/metric reports. &nbsp; EXPERIENCE Minimum 12 years of GCP/GVP Quality Assurance experience. Strong understanding of small molecule products with direct experience in solid oral dosage forms. &nbsp; EDUCATION Bachelor’s or advanced degree in Biology, Chemistry, or related field. The salary range for this position is $236,000 USD to $295,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; Alumis Inc. is an equal opportunity employer. &nbsp;Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp;

Senior Director of Clinical Quality Assurance

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;We have recently completed our pivotal trials of envudeucitinib, our second-generation tyk2 inhibitor in moderate to severe plaque psoriasis and expect results from a potentially pivotal Phase 2b trial in SLE in the third quarter of 2026. As a key member of the Alumis team, you will provide overall leadership for the Medical Affairs function, overseeing Medical Affairs, Field Medical Liaisons, and publications. The position will liaise closely with the clinicians responsible for carrying out Alumis’ clinical studies as well as our commercial group. Applicants should be a “leader/doer” capable of generating strategies and leading cross functionally. This VP, Medical Affairs will report directly to the Chief Medical Officer.&nbsp; Responsibilities Lead the Medical Affairs function at&nbsp;Alumis&nbsp; Develop and implement key&nbsp;Medical&nbsp;Affairs strategies and activities to support the development of our lead assets&nbsp; Continue to build and scale the Medical Affairs organization Develop and present Medical Affairs operational plans to Development and Executive management&nbsp; Represent company externally&nbsp; Direct and oversee all aspects of Medical Affairs and pre-launch needs Lead medical launch preparations for our lead Psoriasis candidate, ensuring the scientific narrative is robust and well-vetted. As a member of the Development Leadership Team, run&nbsp;and continue to build the Medical Affairs&nbsp;function&nbsp; Build and lead a best-in-class global medical affairs team to support launches of multiple indications with a focus on psoriasis for our lead asset, envudeucitinib &nbsp; Develop key performance indicators and generate analytical reports related to Medical Affairs plans and Medical Science Liaison group activities&nbsp; Develop and implement Medical Communication and Disease State Awareness strategies&nbsp; Partner with KOLs to gather information on current focused therapeutic area issues and questions&nbsp; Collaborate with the Commercial team to develop educational material for providers and patients that are balanced and medically accurate&nbsp; Provide direction and input into the development and implementation of successful reimbursement and market-access strategies&nbsp; Work closely with the members of the clinical development and commercial leadership teams to develop the overall strategic direction for Alumis, evaluate alternative strategies, identify competitive issues, and develop and implement operating plans to achieve company objectives&nbsp; Foster collaborative relationships with academic and clinical experts, publishers, medical and patient associations, and other relevant external and internal stakeholders Develop&nbsp;and manage departmental budgets that effectively achieve desired goals and are balanced with the financial&nbsp;objectives&nbsp;of the broader organization&nbsp; Oversee the publication strategy, ensuring clinical data is presented at major congresses (e.g., AAD, EADV, ACR) and in high-impact peer-reviewed journals. Education | Experience | Skill Requirements 10+ years of professional experience within Biotech/Pharma in Medical Affairs&nbsp;&nbsp; 5+ years of people leadership experience&nbsp; An understanding of government and industry guidelines, regulations, laws, etc., for appropriate scientific/medical exchange and communication with customers&nbsp; Ability to lead by example, attract and develop talent, build interdependent partnerships, and create a culture of collaboration and teamwork that fosters open communication, constructive conflict resolution and organizational flexibility&nbsp; Ability to prioritize and manage several complex projects simultaneously&nbsp; Proven ability to develop internal relationships in a highly matrixed environment, as well as external relationships with Key Opinion Leaders and industry experts&nbsp; Ability to communicate effectively at all levels and present complex and/or new ideas with clarity and simplicity&nbsp; Ability to prioritize concurrent projects with tight deadlines and operate in a highly compliance-driven environment&nbsp; Excellent written, verbal, and interpersonal skills, and the ability to communicate at all levels within the company&nbsp; Travel (25-40%) may be required to represent the company at medical conferences, presentations, and other meetings Our headquarters are located in the San Francisco Bay Area and regular presence at headquarters is required Extensive prior experience in dermatology, particularly psoriasis is required. Prior experience in SLE is highly desirable. Prior experience taking a product form Phase 3 to a successful launch is also highly desirable.&nbsp; Advanced degree (PharmD, Ph.D. or MD) is required, MD is preferred. The salary range for this position is $315,000 USD to $370,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.&nbsp; &nbsp;

Vice President, Medical Affairs

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The&nbsp;Associate&nbsp;Director,&nbsp;Data Management&nbsp;plays&nbsp;a central role&nbsp;in&nbsp;delivering high&nbsp;quality, inspection-ready&nbsp;clinical trial data across&nbsp;Alumis’ development programs. This role will&nbsp;primarily&nbsp;support&nbsp;the&nbsp;Phase 3 program&nbsp;for&nbsp;envudeucitinib, a next-generation,&nbsp;highly selective&nbsp;oral&nbsp;TYK2 inhibitor&nbsp;for&nbsp;patients with moderate-to-severe plaque psoriasis.&nbsp;The Associate Director will be instrumental in enabling data deliveries that support a planned New Drug Application (NDA) submission to the FDA in the second half of 2026. You will be joining Alumis at a pivotal and fast-paced stage of development. In this role, you will lead end-to-end data management activities for one or more late-stage clinical studies. You will partner closely with cross-functional teams and external vendors to ensure clinical data meets regulatory standards in a timely and high-quality manner to support key development and regulatory milestones. From managing database transfers and ongoing data review to driving timelines through database freeze and lock, you will drive late-stage processes that enable the advancement of therapies with the potential to meaningfully improve patients’ lives.&nbsp; Essential Responsibilities Study Leadership &amp; Delivery&nbsp; Serve as&nbsp;Data Management Study Lead for&nbsp;a phase III study&nbsp; Ensure DM deliverables are completed on time&nbsp;and&nbsp;in accordance&nbsp;with&nbsp;quality standards and regulatory requirements&nbsp;from study start-up through&nbsp;study closure/archival&nbsp; Represent Data Management in cross-functional study team meetings&nbsp; Data Quality &amp; Review&nbsp;&nbsp; Perform supplemental data reviews according to the data quality checks outlined in the data validation specifications or Clinical Data Review Plan (CDRP)&nbsp; Participate in reviews of blinded TFL output before final database locks&nbsp; Report query trends and data/query/SDV metrics to the Study Execution Team (SET)&nbsp; Vendor &amp; Cross-Functional Collaboration Establish and&nbsp;maintain&nbsp;strategic business relationships with CDM vendors; apply effective vendor management throughout the study&nbsp; Participate in the RFP process,&nbsp;including the evaluation of potential vendors&nbsp; Participate in study document reviews,&nbsp;e.g.&nbsp;clinical study protocols, statistical analysis plans, Mock Tables, Figures,&nbsp;and Listings (TFL) shells&nbsp; Document &amp; Inspection Readiness Responsible for ensuring complete and&nbsp;accurate&nbsp;CDM documentation,&nbsp;such as eCRF specifications, eCRF completion guidelines, annotated CRFs, data validation specifications, data transfer agreements,&nbsp;and data management plans&nbsp; Ensure DM project documentation is in an inspection-ready state&nbsp; &nbsp;Operational Excellence&nbsp;&nbsp; Prioritize projects and coordinate data management activities and deliverables in alignment with corporate goals and&nbsp;objectives&nbsp; Contribute to or lead initiatives focused on data quality, efficiency, and process improvement&nbsp; May provide line management or mentoring for DM support roles&nbsp; &nbsp;Systems, Testing &amp; Data Flow Perform thorough development testing of the eCRF prior to deployment, inclusive of creating User Acceptance Test (UAT) Plans, Test Scripts and executing testing as applicable&nbsp; Ensure&nbsp;accurate&nbsp;development and execution of data integrations between EDC, IXRS and/or external vendor data sources&nbsp; Responsible for setup and management of data transfers for assigned studies, including review of test data transfers for consistency with data transfer agreements&nbsp; Participate in the development of EDC custom report specifications, SAS Clinical Programming report specifications and/or associated outputs as needed&nbsp; The Ideal Candidate 10+ years of relevant clinical data management experience;&nbsp;BS or equivalent required&nbsp;(MS or MBA a plus)&nbsp; Extensive experience supporting Phase&nbsp;III&nbsp;clinical trials&nbsp;in a lead role&nbsp; Strong&nbsp;expertise&nbsp;in&nbsp;EDC&nbsp;systems&nbsp;and related&nbsp;technologies&nbsp;(e.g., IXRS, external data integrations, data visualization)&nbsp; Proficiency&nbsp;with CDISC standards (CDASH, SDTM,&nbsp;ADaM)&nbsp; Experience with SAS, SQL, and/or clinical programming tools&nbsp; Strong understanding of FDA regulations, ICH GCP, and inspection readiness&nbsp;expectations&nbsp; Working knowledge of MedDRA and WHO Drug coding dictionaries&nbsp; Excellent communication, organization, and cross-functional collaboration skills&nbsp; Demonstrated ability to&nbsp;manage multiple priorities,&nbsp;identify&nbsp;risks, solve complex problems, and adapt in a fast-paced environment&nbsp; Willingness to travel as&nbsp;needed&nbsp; This&nbsp;role is anchored at&nbsp;our South San Francisco, CA&nbsp;headquarters, and&nbsp;local candidates are strongly preferred.&nbsp;Remote&nbsp;candidates&nbsp;may be considered if they can&nbsp;maintain&nbsp;Pacific Time business hours and travel to HQ&nbsp;approximately&nbsp;once&nbsp;per&nbsp;month, or as business needs require. The salary range for this position is $195,000 USD to $225,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Medical, dental, and vision insurance with 90% of employee premiums and 80% of dependent premiums covered 401(k) plan with company match Free access to the Genentech Bus Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Onsite gym and fully stocked kitchen with snacks and beverages And more! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. Alumis Inc. is an equal opportunity employer.

Associate Director, Data Management

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer – our goal is to fundamentally change the outcomes for these patients. We are seeking an experienced and motivated Director, Commercial Program Management. In this highly visible, exciting role, you will guide our commercial team in partnership with the molecule development team and cross-functional team leads, providing exceptional program management for our lead molecule envudeucitinib (envu), which disclosed positive Phase 3 data for psoriasis in January 2026. This position will report to the Head of Program and Portfolio Management (PPM). RESPONSIBILITIES Strategic thought partner with the Commercial Lead on Brand Plan and Launch Playbook for lead molecule envudeucitinib (envu) Provide Project Management support on envu Launch Readiness Team (eLRT) as well as coordinate and align Commercial workstreams, managing team and workstream activities, including agenda management, meeting facilitation, minutes and tracking of action items and team deliverables Facilitate team execution on integrated Launch Playbook, in support of molecule’s strategy and Brand Plan objectives, including timelines, budget, and risks Proactively identify, analyze and communicate decision points and risks, framing options within broader molecule context Ensure effective communication within functional Commercial team and across cross-functional stakeholders, including molecule Project Team and Executive Committee members, to support good decision-making in fast-paced small company environment Act as a vendor liaison, providing contract, requisition processing, and invoice management support, as well as following up with vendor on project updates and status reports, to ensure timely and quality deliverables Identify needs and propose solutions to project and portfolio tools, systems and practices to support the growth and evolution of PPM’s capabilities Support other business priorities as needed within PPM, including but not limited to potential assignments in research, development, clinical, medical affairs or CMC project or business management Manage others as needed THE IDEAL CANDIDATE Minimum 12 years industry experience, with at least 5 years of direct drug development project management (e.g. research, development, CMC, medical affairs, commercial) Experience with commercial launch Highly skilled in communication, stakeholder management, and influencing without authority, where you are able to effectively interact with, and facilitate complex conversations across the organization Excellent critical thinking, verbal and written communication skills, with ability to simplify and integrate multiple cross-functional perspectives and inputs for team Agile and flexible: Able to step in, assess situations, and help team to make sound decisions in alignment with program strategy Strong organizational skills with critical attention to detail and ability to track to numerous deliverables Broad scientific and business acumen in the biotech or pharmaceutical industry, including a strong understanding of cross-functional dependencies Proficient with Microsoft Office Suite, as well as project management software such as MS Project and Smartsheets EDUCATION A. or BSc. with MSc., MBA or Ph.D. a plus Project Management Professional (PMP) or other PM certification a plus The salary range for this position is $197,000&nbsp;USD to $247,000&nbsp;USD annually. This salary range is an estimate, and the actual salary&nbsp;may&nbsp;vary&nbsp;based&nbsp;on the Company’s compensation practices. This position is located in South San Francisco, CA, with an expectation to be onsite Tuesday through Thursday.&nbsp; Alumis Inc. is an equal opportunity employer. We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;

Director, Commercial Program Management (Contractor)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;&nbsp; Senior Manager, Pharmacovigilance Safety Operations The Senior Manager, Pharmacovigilance (PV) Safety Operations will report to the Director, PV Safety Operations. This role will play a critical role in ensuring timely reporting, processing, and submission of ICSRs from ongoing clinical trials and post-marketing trials. This role involves overseeing case processing vendors, managing ICSR process, collaborating with cross-functional teams study execution teams, assisting with inspection readiness activities, all while compliance with regulatory requirements. &nbsp; Essential Responsibilities ICSR Operational Excellence/Vendor Oversight • Provide end-to-end operational oversight of ICSR intake, processing, follow-up, quality control, and submissions performed by our outsourced PV vendors. • Ensure accurate and timely processing of ICSR to ensure accuracy and consistency, and compliance with Alumis standard operating procedures (SOP) and PV system expectations. • Lead the development and maintenance of safety management plans and submission tracking systems. • Support the development and maintenance of SOPs. • Coordinate internal medical review activities in collaboration with medical case reviewers. • Monitor case flow to ensure timely exchange for submissions. • Review operational trends and quality indicators to proactively identify risks and drive corrective actions. • Collaborate with clinical operations, data management, and PV teams to perform database reconciliation for clinical trials. • Track the submission of safety reports to regulatory authorities and ensure compliance with country or regional submission deadlines. • Ensure all safety operations are conducted in compliance with FDA, ICH, and other relevant regulatory guidelines. &nbsp; Cross-Functional Collaboration • Work closely with clinical development, regulatory, and quality assurance teams to align safety operations with overall study objectives and ensure regulatory compliance. • Assist in the preparation of new clinical trials study start up activities such as review Safety sections of clinical trial protocols, Informed Consent Forms, clinical database configurations, including User Acceptance Testing and Safety Case Report Forms. • Collaborate with Safety Surveillance and assist in the preparation of surveillance meeting materials from safety operation perspective and assist with the development of aggregate reports, such as Development Safety Update Report (DSUR), Periodic Adverse Drug Experience Report (PADER), Periodic Benefit-Risk Evaluation Report (PBRER) by performing various activities such as quality control. • Contribute to PV system audit-readiness and support inspections activities. The Ideal Candidate • Bachelor’s degree in life sciences, pharmacy, or a related field. • Minimum of 7+ years of experience in safety operations in the biopharmaceutical industry. • Experience with early and late-stage clinical trials (Phase 3) and post-marketing are highly desirable. • Experience with device safety reporting and regulatory inspections is a plus. • Strong knowledge of regulatory requirements (e.g., FDA, ICH guidelines) and industry standards related to drug safety and case processing. • Demonstrated experience in vendor oversight, submission tracking, and quality control. • Excellent organizational, analytical, and communication skills. • Ability to work independently and collaboratively in a fast-paced environment and manage multiple projects simultaneously. • Leads self by managing and executing own work to deliver results that contribute to accomplishing common department goals • Proficiency in safety databases and software tools (e.g., Oracle Argus, ARISg, MedDRA). &nbsp; &nbsp; This role is anchored at our South San Francisco, CA headquarters, with an expectation to be onsite Tuesday through Thursday. While we prefer local candidates, remote applicants based in the Pacific Time Zone will be considered on a case-by-case basis with the ability to travel to HQ approximately once per month, or as business needs require. &nbsp;

Senior Manager, Pharmacovigilance Safety Operations

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;We are seeking an experienced&nbsp;Senior Manager, Statistical&nbsp;Programming&nbsp;to drive the development and validation of statistical programs for late-stage clinical studies. In this role, you will ensure programming activities align with SOPs and regulatory requirements, delivering high-quality and&nbsp;timely&nbsp;results. This is an exciting opportunity to contribute to critical drug development efforts while driving efficiency and compliance in statistical programming.&nbsp; &nbsp; RESPONSIBILITIES &nbsp; Lead the development and validation of statistical programs to ensure high-quality deliverables for both in-house and outsourced projects, adhering to company and regulatory requirements.&nbsp; Drive ISS/ISE analysis tasks in support of NDA submissions.&nbsp; Assist&nbsp;in planning and coordinating&nbsp;project work to ensure&nbsp;timely&nbsp;and high-quality delivery across multiple studies.&nbsp; Develop and review programming plans,&nbsp;dataset&nbsp;specifications,&nbsp;and TLFs;&nbsp;apply&nbsp;expertise&nbsp;in&nbsp;CDISC standards, including SDTM and&nbsp;ADaM&nbsp;models.&nbsp; Review documents produced by biometric functions such as SAPs, CRFs, data review plans,&nbsp;and&nbsp;data transfer&nbsp;agreements.&nbsp; Oversee&nbsp;CRO programming activities,&nbsp;reviewing&nbsp;and validating CRO&nbsp;deliverables including&nbsp;SDTM,&nbsp;ADaM&nbsp;and TLFs,&nbsp;while&nbsp;providing&nbsp;solutions to&nbsp;any&nbsp;issues raised by CROs.&nbsp; Review&nbsp;eSubmission&nbsp;datasets and data documentation&nbsp;such as&nbsp;aCRF, reviewer guides, define documents&nbsp;and programs to ensure all files meet submission requirements.&nbsp;&nbsp; Develop macros to support study and project activities,&nbsp;contributing&nbsp;to&nbsp;global macro tools that&nbsp;enhance the&nbsp;overall efficiency and&nbsp;capacity&nbsp;of&nbsp;the&nbsp;programming function.&nbsp; Maintain deep familiarity&nbsp;with ICH guidelines&nbsp;and&nbsp;advanced knowledge of&nbsp;regulatory&nbsp;submission requirements,&nbsp;ensuring&nbsp;all&nbsp;statistical programming deliverables&nbsp;meet&nbsp;industry and company standards.&nbsp; Support the preparation of clinical study reports, regulatory submissions, DSURs,&nbsp;and safety reports&nbsp;across&nbsp;multiple studies.&nbsp; Contribute to the development,&nbsp;implementation&nbsp;and continuous improvement of programming processes&nbsp;and standards.&nbsp; Communicate&nbsp;effectively&nbsp;within&nbsp;project teams,&nbsp;across&nbsp;departments,&nbsp;and with external collaborators.&nbsp;&nbsp; &nbsp; THE IDEAL CANDIDATE &nbsp; Expert-level SAS programmer with&nbsp;a proven&nbsp;track-record&nbsp;of&nbsp;delivering complex programming assignments and analyses.&nbsp; Skilled&nbsp;in&nbsp;writing original cold, developing&nbsp;macros&nbsp;and&nbsp;modifying&nbsp;existing&nbsp;code.&nbsp; Experience in developing&nbsp;and implementing&nbsp;statistical programming standards and procedures.&nbsp; Expert level knowledge and extensive hands-on experience&nbsp;with&nbsp;CDISC standards&nbsp;including&nbsp;CDASH, SDTM, and&nbsp;ADaM.&nbsp; Experience leading teams supporting FDA,&nbsp;EMEA, and&nbsp;CDE&nbsp;regulatory&nbsp;filings.&nbsp; Strong interpersonal&nbsp;skills with&nbsp;excellent written and verbal&nbsp;communication.&nbsp; Meticulous&nbsp;attention to detail and consistency.&nbsp; &nbsp; &nbsp; EDUCATION &nbsp; Bachelor’s degree&nbsp;(or&nbsp;equivalent),&nbsp;preferably in&nbsp;a computational&nbsp;or biological science, with&nbsp;a&nbsp;minimum of&nbsp;8&nbsp;years of&nbsp;direct&nbsp;experience in&nbsp;drug development.&nbsp;&nbsp; Master’s&nbsp;degree with&nbsp;minimum&nbsp;of&nbsp;6&nbsp;years of related experience.&nbsp; &nbsp; &nbsp; &nbsp; This position&nbsp;is located in&nbsp;South San Francisco, CA. At this&nbsp;time&nbsp;we are not considering remote applicants. &nbsp; &nbsp; The salary range for this position is&nbsp;(P&amp;C will insert compensation&nbsp;band&nbsp;)&nbsp;USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.&nbsp; &nbsp; Alumis&nbsp;Inc. is an equal opportunity employer. &nbsp;

Senior Manager, Statistical Programming

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Position Purpose &nbsp; The VP of Corporate Communications and Investor Relations will lead the development and implementation of Alumis’ strategic communications initiatives to build identity,&nbsp;reputation&nbsp;and visibility across multiple stakeholders, including media, patient advocacy, potential&nbsp;customers&nbsp;and employees. Reporting to the Chief Finance Officer, the position will work closely with Alumis’ executive and senior leadership, investor&nbsp;relations&nbsp;and other key stakeholders.&nbsp; Job Description and Key Responsibilities&nbsp; The Communications position will play a key&nbsp;role&nbsp;generating the internal and external communications strategy for our portfolio of assets and corporate messages to ensure the company's evolving story is communicated effectively. This position will work across functional areas including corporate communications/ PR, commercial, investor relations, clinical, medical affairs,&nbsp;research&nbsp;and HR. They will be the point person for generating,&nbsp;reviewing&nbsp;and deploying communication initiative across various mediums (with subject matter&nbsp;expertise&nbsp;assistance) and responsible for consistently communicating across multiple channels and platforms, including media and scientific conferences.&nbsp; Specific responsibilities include but are not limited to:&nbsp; Develop communications strategies and plans that effectively communicate corporate and product stories to external audiences; generate awareness and a positive external response to the company’s vision and corporate objectives&nbsp; Provide leadership, development, direction, and management of all external communications initiatives, including media and key constituency relations.&nbsp; Partner with the executive team and other functional team members to develop and&nbsp;maintain&nbsp;overall stewardship of the corporate brand,&nbsp;positioning&nbsp;and messaging&nbsp; Act as a strategic communications advisor to product and project teams, to support and advise on communications and message development&nbsp; Direct media relations program;&nbsp;establish&nbsp;and maintain excellent and productive relationships with healthcare, biotech&nbsp;business&nbsp;and local media&nbsp; Support the development of high-quality communications materials and messages, including press releases, fact sheets, talking points and Q&amp;A documents&nbsp; Create and update content on&nbsp;Corporate&nbsp;website&nbsp; Serve as point among internal stakeholders, such as legal, commercial, clinical operations and regulatory/compliance and SME (subject matter experts) for key external communications&nbsp; Support the development of collaborative, mutually beneficial partnerships with patient advocacy groups&nbsp; Oversee public relations agencies and associated budgets and program&nbsp;measurement. &nbsp; Assist&nbsp;in development of internal communications with the aims of fostering morale and our internal ethos and understanding of&nbsp;company, of making&nbsp;internal, HR/benefit, and other information accessible, of integrating new employees, and&nbsp;assisting&nbsp;in rolling out of internal initiatives.&nbsp; Key Requirements and Qualifications&nbsp; 7+ years of progressive communications experience in pharmaceuticals/ biotech&nbsp; Experience in or with public pharmaceuticals/ biotech companies is&nbsp;a must; combination of PR agency and in-house experience preferred; experience with late-stage programs and commercial products/launches a plus &nbsp; Solid&nbsp;track record&nbsp;of&nbsp;identifying&nbsp;and analyzing communications opportunities and business issues and developing and leading external and internal communications with best-in-class communication practices&nbsp; Demonstrated ability to adapt to evolving market and competitive dynamics, and&nbsp;utilize&nbsp;sound judgment to&nbsp;establish&nbsp;appropriate solutions&nbsp; Extensive and successful experience with developing and executing&nbsp;communication&nbsp;strategies and tactics&nbsp; Strong executive leadership skills, communication,&nbsp;presentation&nbsp;and business partnering ability &nbsp; Proven ability to work with and effectively influence leadership teams while&nbsp;operating&nbsp;in a fast-paced, entrepreneurial, decisive/deadline-oriented environment, heavily regulated&nbsp;industry;&nbsp;strong interpersonal skills and ability to work with others in a positive, collaborative manner&nbsp; High level&nbsp;of intellectual curiosity combined with strong strategic and analytical skills &nbsp; Demonstrated ability to build strong customer relationships&nbsp; Excellent planning and organizational skills, with a keen ability to multi-task &nbsp; Knowledge of commercial compliance and all laws and regulations that govern our industry&nbsp; Ability to travel domestically and internationally&nbsp; Proficient in Microsoft Word, Excel,&nbsp;SharePoint&nbsp;and PowerPoint&nbsp; BA/BS&nbsp;required, MBA preferred&nbsp; &nbsp; &nbsp; The salary range for this position is $285,000 USD to $350,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Open to remote applicants. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp;

Vice President Corporate Communications & Investor Relations

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer – our goal is to fundamentally change the outcomes for these patients. We are seeking a talented and motivated leader to join our IT team as the Sr. Manager, IT, R&amp;D Applications (Contractor), supporting core business applications for corporate enterprise needs across Development and Research teams including QA, Clinical Operations, Biometrics, Medical Affairs, and Regulatory functions. This position may also assist in supporting initiatives on the enterprise and cross-departmental level. In this role, you will collaborate closely with stakeholders and manage implementation, maintenance, and ongoing support for the SaaS technologies used by these business functions to enhance efficiency and drive business outcomes. The ideal candidate has a solid technical background, is well organized, works independently, and possesses a “can-do” attitude. This role reports to the Director, R&amp;D Business Partner. Duties &amp; Responsibilities Act as an application technology partner to R&amp;D business owners, ensuring technology solutions align with departmental objectives and business functionality. Translate business needs into clear technical requirements by maintaining regular engagement with business owners across the R&amp;D department Proactively identify opportunities where technology, data, or process improvements can drive efficiency, reduce risk, or enhance operational outcomes. Lead and gather business requirements, processes, and drive implementation of change requests. Oversee the design, configuration, implementation, and maintenance of relevant R&amp;D applications. Drive continuous improvement initiatives to optimize application performance and enhance user’s experience. Collaborate with cross-functional teams to integrate applications with other enterprise systems. Lead the R&amp;D application upgrades and implementations as the IT System owner Manage and oversee user administration, workflow development, operational support, troubleshoot, and resolve R&amp;D business application production issues. Ensure IT policies and procedures are communicated to all personnel and compliance is maintained. Establish/maintain relationships with internal business owners, technology teams and external technology vendors. Support Computer System Validation processes for GxP applications Qualifications Bachelor’s degree in Computer Information Systems, Business Administration or related discipline. 8+ years of industry experience in commercial Biotech, Pharma or Life Sciences Company. Knowledge of Drug Development process and sub-process within each department, with an emphasis on Biometrics, QA, and Clinical Operations Experience developing relationships with and ensuring the appropriate participation of key stakeholders and internal customers. Extensive knowledge of Cloud Systems in a Life Sciences Environment Experience with implementing, integrating, and managing R&amp;D software solutions such as Veeva Vault (QualityDocs, LMS, Promomats, Medical CRM), SAS, DocuSign Part 11, PhelxGlobal eTMF Strong working knowledge of System Development Life Cycle methodologies in project delivery. Extensive knowledge of Regulatory requirements and standards (FDA 21CFR Part 11) Exceptional vendor management skills. Superior organization, planning, and project management skills Ability to work in a small, fast-paced IT team. Ability to distill technical concepts and present to a non-technical audience. Accuracy and responsibility, ability to work with minimal supervision. Excellent customer service skills and ability to demonstrate a passion to assist and add value to department and company. Excellent analytical, troubleshooting, and decision-making skills. Proven ability to perform effectively under conditions such as project changes, tight deadlines, limited resources. &nbsp; This position is located in South San Francisco, CA. At this time, we are not considering fully remote applicants. The salary range for this position is $168,000 – $200,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer. &nbsp; &nbsp; &nbsp;

Senior Manager, IT, R&D Applications (Contractor)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The Data Systems &amp; Clinical Programming Specialist (Contractor) will be responsible to support Data Management (DM) as part of the Clinical Programming function in a rapidly evolving environment, in accordance with industry standards. This role will support Data Systems and Clinical Programming activities and deliverables across programs as directed by the Director and Associate Director, DS&amp;CP. Essential Responsibilities: Support development and production operation activities within the Data Systems and Clinical Programming function Maintain Smartsheet trackers for report requests, Production reports, and other DS&amp;CP operational documentation Participate in the development of report specifications for SAS Clinical Programming reports, and other custom reports/outputs as needed Review programmed reports/outputs for accuracy against requirements and provided specifications Provide/transfer source files for reports and dashboards and ensure automated transfers have completed successfully Transfer programmed reports/outputs to appropriate locations for cross-functional team use Support requests for new/updated Automated Transfer Service (ATS) vendors and jobs and investigate issues or trigger jobs manually as needed Provide user access for DM tools Support Alumis’ standard CRFs and standard edit checks initiatives Participate in EDC, IRT, and eCOA User Acceptance Testing (UAT) Ensure DS&amp;CP study-specific documentation is in an inspection-ready Support DS&amp;CP in cross-functional meetings, as applicable Ensure DS&amp;CP project deliverables are completed on time and in accordance with quality standards and regulatory requirements Ensure compliance with all relevant data privacy regulations and maintain the security of clinical trial data Qualifications: 5+ years of relevant experience and has earned a BS or equivalent degree 2+ years of experience with clinical trials and data management Understanding of the programming development life cycle Knowledge and experience in EDC Experience with SAS, SQL, and/or other clinical programming tools Experience working and effectively communicating with global programming teams preferred Experience with CDISC standards (CDASH, SDTM) preferred Strong interpersonal, organizational, and communication (oral and written) skills Logical thinking, attention to detail and accuracy, strong organizational skills, and problem-solving abilities Ability to prioritize and to adapt quickly to changing business conditions with a “can-do” attitude

Data Systems & Clinical Programming Specialist (Contractor)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; &nbsp; We are seeking an experienced Regional Director of Medical Science Liaisons (MSLs) with expertise in medical dermatology. The successful candidate will be responsible for leading and overseeing MSLs, ensuring the effective dissemination of scientific and clinical information, building relationships with key opinion leaders (KOLs), and supporting the strategic goals of the Medical Affairs organization. This role will require a deep understanding of medical science, excellent leadership capabilities, and a strong ability to drive the success of cross-functional teams. We will be seeking one individual for the Western US and one for the Eastern US. &nbsp; Responsibilities: Field-based Leadership of Regional DPEGs and IDNs Serve as primary point of contact with the clinical leaders, educational leaders, and C-suite executives of Dermatology Private Equity-backed Groups, DPEGs, to build trusting professional relationships Develop deep understanding of DPEG structures, performance metrics, and educational needs Develop cross-functional engagement strategy to build the groundwork for launch Co-create data-driven value proposition to improve patient outcomes Leadership &amp; Team Management: Lead, mentor, and manage a team of MSLs, fostering a collaborative, high-performing, and scientifically rigorous culture. Provide guidance on the development and execution of territory plans, objectives, and key performance indicators (KPIs) for each MSL. Conduct regular performance evaluations, identify skill gaps, and support MSL development through coaching, training, and career growth opportunities. Collaborate with the Medical Affairs leadership team to align MSL activities with organizational priorities and strategic initiatives. Strategic Planning &amp; Execution: Contribute to the development of MSL tactics in line with corporate and therapeutic area goals. Drive the execution of MSL tactics within assigned region. Ensure MSLs are equipped with the latest scientific data and clinical information, and support their integration into both regional and national-level initiatives. Scientific Exchange &amp; KOL Relationship Management: Cultivate strong, long-lasting relationships with KOLs, healthcare providers, academic researchers, and key stakeholders through active field engagement in the region. Serve as a scientific resource and point of contact for KOLs to address inquiries regarding the company’s pipeline, products, and scientific advancements. Represent the company at scientific congresses, advisory boards, and other relevant forums to enhance scientific and therapeutic understanding. Cross-Functional Collaboration: Provide strategic input into the development of clinical trials, publication plans, and other medical activities by leveraging field insights and customer feedback. Collaborate with the Medical Affairs leadership to ensure appropriate deployment of MSL resources to support clinical, regulatory, and commercial objectives. Compliance &amp; Reporting: Ensure all MSL activities are conducted in compliance with regulatory, ethical, and company standards, including GxP (Good Clinical Practice) and HIPAA regulations. Provide regular updates to MA management on team progress, KOL engagement, and other key initiatives, including metrics on impact and outcomes. Stay abreast of the competitive landscape and emerging trends in dermatology, rheumatology, and neurology, ensuring MSL activities reflect the latest scientific advancements. &nbsp; Qualifications: Education: o PhD, PharmD, MD, or other advanced degree in a relevant scientific discipline (e.g., Biology, Pharmacology, Medicine). Experience: o Minimum of 10 years of experience in Medical Affairs or related scientific roles, with leadership experience in managing a team of MSLs or scientific professionals. o In-depth knowledge of medical dermatology, including clinical practice, research, and evolving treatment paradigms. o Proven track record of successful relationship-building with KOLs, HCPs, and key stakeholders within the medical community. o Experience working in cross-functional teams, with a demonstrated ability to collaborate effectively with commercial, clinical, regulatory, and other business functions. Skills &amp; Competencies: o Excellent leadership and team management skills, with the ability to inspire and develop a high-performing team. o Strong communication, presentation, and interpersonal skills, with the ability to engage effectively with internal and external stakeholders. o Deep understanding of the pharmaceutical industry, including regulatory and compliance requirements, scientific data dissemination, and product lifecycle management. o Ability to translate complex scientific information into actionable insights for diverse audiences, including KOLs, healthcare professionals, and internal teams. o Strong problem-solving, strategic thinking, and decision-making skills. Travel: o Willingness to travel extensively (50-75%) as required for KOL engagement, scientific meetings, and team management activities. Preferred Qualifications: · Experience in therapeutic areas of medical dermatology. · Previous experience working in a leadership role within a biopharmaceutical company or a global pharmaceutical organization. · Familiarity with clinical trial processes, publication planning, and scientific communication in a corporate environment. The salary range for this position is $220,00 to 250,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background. &nbsp; This position is primarily remote with travel. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Regional Director of MSLs

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Director, GCP Compliance&nbsp; Alumis Inc is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer – our goal is to fundamentally change the outcomes for these patients. Reporting to the Executive Director, GCP Compliance, the Director of GCP Compliance serves as a strategic leader responsible for GCP oversight, Inspection Readiness (IR), and cross-functional quality partnership. This role provides GCP Compliance direction for clinical programs, advances clinical process excellence, and ensures development programs operate with the highest standards of quality, compliance, and inspection readiness. Strategic Priorities Lead Inspection Readiness (IR) strategy and execution across assigned clinical programs, ensuring teams are prepared for regulatory engagement. Serve as a strategic partner to QA, collaborating on compliance risk mitigation, quality signals, and inspection readiness activities. Provide strategic oversight for issue management across clinical programs, ensuring GCP issues are identified, assessed, escalated, and resolved with urgency and transparency. Drive the development and reporting of compliance metrics, dashboards, and tools that enable clear, data‑driven quality decisions. Champion a culture of quality and compliance within Development, serving as a visible advocate in partnership with QA. Operational Responsibilities Lead GCP training initiatives, including development and delivery, ensuring content is current, impactful, and aligned with organizational growth. Support the evolution of Clinical Study Management processes to align with regulatory expectations and operational excellence. Partner with Development Operations, Biometrics, Pharmacovigilance, QA, and Regulatory Affairs to proactively identify and mitigate compliance risks. Develop and deliver GCP training programs for internal teams and external partners to champion a quality-first mindset, reinforcing consistent compliance behaviors. Support initiatives that reinforce strong procedural compliance across clinical programs Collaborate with QA on deviation management, CAPAs and audit/inspection finding resolution and close out. The Ideal Candidate Holds an advanced degree in Life Sciences, Pharmacy, or related field is preferred. Brings 10+ years of experience in GCP quality/compliance, including 3+ years in a leadership role. Possesses deep knowledge of ICH-GCP, FDA, EMA, and other global regulatory requirements. Demonstrates proven success supporting or leading inspection readiness and serving as an interface with global health authorities during inspections. Communicates with clarity, leads with influence, and builds trust across teams. Experience in biotech or pharmaceutical industry, ideally in late-stage clinical development. Combines strategic insight with strong operational execution, translating executive direction into clear, actionable initiatives. Acts with high integrity and commitment to ethical research practices; able to navigate complex regulatory and organizational environments. Leads with collaboration and agility, fostering strong relationships and effective decision‑making across the organization. This position is located in South San Francisco, CA, with an expectation to be on-site Tuesday through Thursday. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; &nbsp; The salary range for this position is $200,500 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp;

Director, GCP Compliance

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is seeking a Director of Clinical Pharmacology &amp; DMPK to drive clinical pharmacology strategy and PK/PD modeling for our small-molecule programs in immune-mediated diseases. This role partners closely with cross-functional teams and reports to the Head of Clinical Pharmacology &amp; DMPK. Specific responsibilities include but are not limited to:&nbsp; &nbsp; Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs. Conduct and interpret PK, PK/PD, exposure–response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp. Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments. Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance. Partner with Clinical Operations on sample management and protocol design. Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs). Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management. Key Requirements and Qualifications&nbsp; PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field. 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology. Strong expertise in PK, PK/PD, DMPK, and translational sciences. Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python). Excellent communication, organization, and ability to work independently in a fast-paced environment. Alumis Inc. is an equal opportunity employer. The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;

Director Clinical Pharmacology & DMPK

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The Director, Data Systems (DS) and Clinical Programming (CP) will be responsible for leading and managing the Clinical Programming function within Data Management (DM). This position will report to the VP, Data Management and Clinical Programming. Responsibilities:&nbsp; Lead and manage the Data Systems and Clinical Programming function within DM Drive the implementation of various technology solutions to augment existing DM processes, optimize efficiency and enhance overall data quality assurance Lead and/or participate in AI-related initiatives for DM Develop and implement strategies for optimizing data flow, database builds, and integration of external technologies. Oversee the validation of the EDC platform, ensuring ongoing system optimization. Manage relationships with key external vendors, ensuring alignment with organizational goals. Ensure compliance with all relevant data privacy regulations and maintain the security of clinical trial data. Ensure DS&amp;CP project deliverables are completed on time and in accordance with quality standards and regulatory requirements. Collaborate with other departments to align data strategy with broader organizational goals and objectives. Mentor and develop team members, fostering a culture of continuous learning and growth within the team. Oversee all SAS clinical programming requests and standardize the clinical programming specification development process. Develop and/or maintain Alumis’ standard CRFs and standard edit checks, inclusive of indication-specific standards. Develop DS&amp;CP SOPs and Work Instructions. Lead the development and/or maintenance of standard vendor Data Transfer Agreements (DTAs). Oversee the development and execution of technical initiatives within DM, including the implementation of key data visualizations and dashboards for DM, such as Clean Patient Tracking, data currency, and rolling batch freeze progress. Integrate the usage of data analytics within DM to further optimize current processes. Provide strategic oversight of high-priority projects, including database builds, user access management, and the release of system updates. Participate in EDC, IRT and eCOA User Acceptance Testing (UAT) Ensure accurate development and execution of data integrations between EDC, IXRS or additional external vendor data sources Ensure DS&amp;CP study-specific documentation is in an inspection-ready state and represent the DS&amp;CP function in inspections as applicable. Represent DS&amp;CP in cross-functional meetings as applicable Act as a key stakeholder in developing and executing strategies to accelerate drug development through innovative data management practices. Qualifications:&nbsp; 12+ years of relevant experience and has earned a BS or equivalent degree; MS or MBA a plus Experience supporting Ph I-IV clinical trials, both in-house and through CRO partners Strong knowledge and experience in EDC and other key technologies (e.g., IXRS, data visualization)&nbsp; Proficiency in CDISC standards (CDASH, SDTM, ADaM) Experience with SAS, SQL and/or other clinical programming tools Proficiency in clinical research regulations and guidance, including FDA CFR and ICH GCP&nbsp; Depth of experience across all aspects of DM, including but not limited to: CRF and database development, data quality assurance and analytics, data transfer management, vendor management, DM study documentation and inspection readiness.&nbsp; Strong understanding&nbsp;of the application of MedDRA and WHO Drug clinical data coding classification systems Strong interpersonal, organizational, and communication (oral and written) skills Demonstrated ability to cultivate strong working relationships with internal and external colleagues. Logical thinking, attention to detail and accuracy, strong organizational skills, and problem-solving abilities Ability to prioritize and to adapt quickly to changing business conditions with a “can-do” attitude Capable of proactively identifying project challenges and risks and proposing appropriate and strategic solutions to issues. Willing to travel if required &nbsp; Alumis Values&nbsp;• We Elevate&nbsp;• We Challenge&nbsp;• We Nurture&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite 1-2x a quarter. The salary range for this position is $200,000 USD to $225,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer. &nbsp; &nbsp;

Director, Data Systems and Clinical Programming

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The Data Management (DM) Contractor will be responsible for ensuring high-quality management of clinical trial data in a rapidly evolving environment, in accordance with industry standards. The DM Contractor will support and/or lead DM activities and deliverables across one or multiple studies. Essential Responsibilities: May serve as DM Study Lead or DM support for one or more studies Represent DM in cross-functional meetings as applicable Ensure DM project deliverables are completed on time and in accordance with quality standards and regulatory requirements from study start-up through study closure/archival Apply effective vendor management throughout the study Responsible for ensuring complete and accurate DM documentation such as eCRF specifications, eCRF completion guidelines, annotated CRFs, data validation specifications, data transfer agreements and data management plans Perform thorough development testing of the eCRF prior to deployment, inclusive of creating User Acceptance Test (UAT) Plans, Test Scripts and executing testing as applicable Ensure accurate development and execution of data integrations between EDC, IXRS and/or external vendor data sources Responsible for setup and management of data transfers for assigned studies, including review of test data transfers for consistency with data transfer agreements Participate in study document reviews, e.g. clinical study protocols, statistical analysis plans, Mock Tables, Figures and Listings (TFL) shells Perform supplemental data reviews according to the data quality checks outlined in the data validation specifications or Clinical Data Review Plan (CDRP) Participate in reviews of blinded TFL output prior to final database locks Report query trends and data/query/SDV metrics to the Study Execution Team (SET) Participate in the development of EDC custom report specifications, SAS Clinical Programming report specifications and/or associated outputs as needed Ensure DM project documentation is in an inspection-ready state Qualifications: 10+ years of relevant experience and has earned a BS or equivalent degree; MS or MBA a plus Experience running Ph I-IV clinical trials, both in-house and through CRO partners Strong knowledge and experience in EDC and other key technologies (e.g., IXRS, data visualization)&nbsp; Proficiency in CDISC standards (CDASH, SDTM, ADaM) Experience with SAS, SQL and/or other clinical programming tools Proficiency in clinical research regulations and guidance, including FDA CFR and ICH GCP&nbsp; Depth of experience across all aspects of DM, including but not limited to: CRF and database development, data quality assurance and analytics, data transfer management, vendor management, DM study documentation and inspection readiness.&nbsp; Strong understanding&nbsp;of the application of MedDRA and WHO Drug clinical data coding classification systems Strong interpersonal, organizational, and communication (oral and written) skills Demonstrated ability to cultivate strong working relationships with internal and external colleagues. Logical thinking, attention to detail and accuracy, strong organizational skills, and problem-solving abilities Ability to prioritize and to adapt quickly to changing business conditions with a “can-do” attitude Capable of proactively identifying project challenges and risks and proposing appropriate and strategic solutions to issues. Alumis Values&nbsp;• We Elevate• We Challenge• We Nurture This position is located in South San Francisco, CA and contractors are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite 1-2x a quarter.

Data Management Contractor

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;We are seeking an experienced Senior Manager, FP&amp;A – Research &amp; Technical Operations to join our team in a fast-paced, high-growth environment. This position will serve as a strategic finance business partner to the Research and Technical Operations organizations, supporting a growing portfolio of programs and operational priorities. In this role, you will play a critical part in driving planning and forecasting processes, delivering decision support for functional leadership, and assisting the Sr. Director of FP&amp;A in overall planning strategy and execution. This position will also involve close interaction with the Accounting team during month-end close processes. Responsibilities Partner closely with Research and Technical Operations teams to provide effective planning, forecasting, and analysis; provide senior leadership and business partners with appropriate tools and insights to set goals and measure performance. Attend cross-functional program and functional leadership meetings; proactively identify risks, opportunities, and tradeoffs and translate them into clear financial implications. Partner with Technical Operations and Accounting to support COGS and gross margin planning/forecasting and related performance analysis. Support Technical Operations’ operating models by validating key assumptions, running scenarios, and communicating financial implications to functional leaders. Own financial reporting for supported functions, including monthly comparison of actual vs. budget/forecast results and relevant variance analysis, in a timely and accurate manner. Collaborate with the Accounting team on monthly close to ensure accruals and expenses are recorded accurately and promptly. Assist Sr. Director, FP&amp;A in the management of the LRP and budget processes, support compliance of internal controls, preparation of finance materials for the Board, and other high priority projects. Collaborate, influence, and build credibility with business partners across the organization, especially within Research and Technical Operations. Educate program and functional leaders about the budgeting/forecasting process and the importance of their role in a successful process. Qualifications Bachelor’s in Finance, Accounting or relevant degree. 7+ years of progressive financial reporting, planning and analysis experience in the pharmaceutical or biotechnology industry. Prior experience supporting Research/R&amp;D and/or Technical Operations organizations is highly preferred. Experience supporting manufacturing/CMC/supply chain finance and partnering through commercialization or launch-readiness activities is a plus. System savvy, ideally with experience implementing or overseeing financial planning and reporting tools. Experience with Adaptive Insights is a plus. Strong and advanced Excel modeling and analytical skills as well as solid accounting knowledge. Strong written, verbal, and interpersonal skills. Alumis Values&nbsp;• We Elevate&nbsp;• We Challenge&nbsp;• We Nurture&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; The salary range for this position is $165,000 USD to $200,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer.

Senior Manager, FP&A - Research & Technical Operations

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; &nbsp; Position Summary Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies evaluating envudeucitinib and A-005 across new indications identified for expansion of the Alumis pipeline. This high-impact role will be instrumental in shaping the company's clinical development portfolio, from indication selection through proof-of-concept studies, and will serve as a key scientific leader interfacing with internal teams, regulatory authorities, and the external medical community. --- Key Responsibilities Clinical Development Strategy &amp; Leadership · Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 and additional pipeline molecules in new therapeutic indications · Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications · Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on program goals, timelines, and deliverables · Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need Study Execution &amp; Oversight · Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity · Oversee medical aspects of study conduct, including safety surveillance, protocol amendments, and data review · Partner with Clinical Operations, Biostatistics, and Regulatory Affairs to ensure efficient study execution and high-quality data generation · Lead interactions with Data Safety Monitoring Boards (DSMBs) and provide medical input for safety analyses Regulatory &amp; External Engagement · Contribute to regulatory strategy and serve as a clinical representative in interactions with FDA and international regulatory authorities (EMA, PMDA, etc.) · Prepare and review clinical sections of regulatory submissions, including IND amendments, briefing documents, and meeting packages · Represent Alumis at scientific conferences, advisory boards, and with Key Opinion Leaders (KOLs) to advance clinical programs and gather external insights · Build and maintain relationships with investigators, academic collaborators, and the broader medical community Cross-Functional Collaboration · Work closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical study designs · Collaborate with Commercial and Medical Affairs teams on disease landscape assessments and indication prioritization · Provide clinical expertise to support business development activities, including evaluation of potential partnerships or in-licensing opportunities Team Development · Mentor and develop junior medical staff, fostering a culture of scientific excellence and collaboration · Contribute to building Alumis's clinical development capabilities as the organization grows --- Required Qualifications · MD required; board certification or fellowship training in Rheumatology, Dermatology, or a related specialty strongly preferred · 10+ years of pharmaceutical/biotechnology industry experience in clinical development, with a significant focus on immunology or autoimmune diseases · Demonstrated experience leading Phase 1 and Phase 2 clinical studies from design through data readout · Track record of successful regulatory interactions (FDA, EMA) and experience preparing IND/CTA submissions · Deep understanding of early clinical development, including dose-finding strategies, biomarker integration, and adaptive trial designs · Strong scientific acumen with the ability to critically evaluate preclinical and clinical data to inform development strategy · Experience with JAK/TYK2 inhibitors or related immunomodulatory mechanisms preferred · Excellent leadership, communication, and interpersonal skills with the ability to influence cross-functional teams in a matrixed environment · Strategic mindset with demonstrated ability to balance scientific rigor with business objectives --- Preferred Qualifications · Experience with indication expansion or lifecycle management for immunology assets · Prior experience at a small or mid-sized biotechnology company; comfort operating in a fast-paced, resource-conscious environment · Established relationships with KOLs in rheumatology, dermatology, or gastroenterology · Experience with multiple autoimmune indications (e.g., psoriasis, psoriatic arthritis, lupus, atopic dermatitis, CNS inflammatory and degenerative diseases) · Familiarity with regulatory pathways for expedited development (Breakthrough Therapy, Fast Track) --- Travel Requirements Travel required (approximately 20-30%) to support investigator meetings, scientific conferences, regulatory interactions, and site visits. --- &nbsp; The salary range for this position is $300,000 USD to $400,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Remote candidates will be considered on a case-by-case basis. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Senior/Executive Medical Director, Clinical Development (New Indications)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is seeking a high-impact Senior Director to help shape and deliver U.S. market access strategy for a late-stage immunology asset in dermatology. Reporting to the SVP of Market Access, this role is designed for someone who thrives in a lean environment, takes ownership beyond their title, and drives strategy through execution. You will operate as a critical member of a&nbsp;small, senior team, expected to deliver outsized impact without the infrastructure of a large organization. This role is best suited for individuals who have succeeded in complex dermatology markets and are motivated to assess issues, identify feasible solutions, make decisions, and operate with efficiency. Key Responsibilities: Strategic Leadership in a Lean Environment Partner directly with the SVP of Market Access to shape and refine U.S. access strategy. Own and drive high-priority components of pricing, payer positioning, and access execution—personally and with limited support. Challenge conventional approaches and bring forward differentiated strategies grounded in real-world payer behavior. Payer Strategy &amp; Market Impact Lead core elements of U.S. payer strategy, including positioning, coverage objectives, and contracting approach in highly managed, rebate-driven markets. Anticipate aggressive payer tactics (step edits, exclusions, reauthorization criteria) and design pragmatic, executable solutions for a small biotech. Engage directly with payer stakeholders and translate insights into actionable strategy. Value Story &amp; Evidence Translation Anticipate the future and develop clear, compelling payer value narratives that differentiate in crowded dermatology markets. Create compelling and workable outcomes contracting options that augment brand position. Translate clinical and economic evidence into practical tools that drive coverage decisions. Partner closely with HEOR and medical to ensure evidence generation is focused, efficient, and directly tied to access impact. Launch Execution &amp; Access Readiness Drive critical components of launch readiness, including payer engagement, distribution strategy input, and patient access solutions. Build—not just direct—key deliverables such as payer materials, access assumptions, and strategy frameworks. Partner with Insights and Analytics to create actionable dashboards for field team deployment. Competitive Edge &amp; Market Awareness Bring urgency and accountability to cross-functional teams. Apply deep understanding of dermatology and immunology market dynamics to anticipate competitor and payer behavior. Recognize patterns from prior market experience and adapt quickly to changing conditions. Continuously refine strategy based on real-time insights. Qualifications 10+ years of U.S. market access experience within biopharma, including an experience in a small company. Proven success driving meaningful components of access strategy in&nbsp;lean or resource-constrained environments. Comfortable navigating ambiguity and making decisions with imperfect information. Dermatology experience strongly preferred; immunology experience required. Experience in highly competitive, rebate-driven therapeutic categories required. Launch experience strongly preferred. Experience operating in small, agile organizations with limited infrastructure. Strong cross-functional leadership skills, with the ability to influence without authority. Agile, solutions-oriented leader with a strong bias for action. Bachelor’s degree required; advanced degree (MBA, PharmD, PhD, MPH) preferred. The salary range for this position is $270,000 USD to $320,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; &nbsp; This position is based in South San Francisco. Local candidates (onsite Tues-Thurs) are preferred. Will consider excellent candidates&nbsp;nation-wide if they are willing to travel regularly to South San Francisco. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents 401k match Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO&nbsp; Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp;

Senior Director, Market Access

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is seeking a highly strategic and execution-oriented Senior Director, Trade Operations to lead the vision, design, and implementation of U.S. trade and distribution models across its dermatology and immunology portfolio. This individual will play a critical leadership role in shaping how products reach patients and providers through agile, efficient, and scalable access pathways. Reporting to the SVP, Market Access, this role will operate as a core member of a lean, high-impact commercialization team. The ideal candidate thrives in a nimble environment, brings a pragmatic and innovative mindset, and is comfortable building strategy from the ground up while remaining deeply involved in execution. Key Responsibilities: Trade &amp; Distribution Strategy Development Lead the design and execution of U.S. trade and distribution strategies, with a focus on specialty pharmacy and specialty distribution channels. Develop nimble, fit-for-purpose distribution models tailored to dermatology and immunology markets, enabling rapid adaptation to evolving payer and patient dynamics. Define channel strategy, including specialty pharmacy network design, limited distribution approaches, and wholesaler partnerships where appropriate. Partner with the SVP of Market Access and other commercialization leaders at Alumis to assess and implement new concepts for channel strategy. Strategic Execution &amp; Launch Readiness Translate strategy into actionable plans, including partner selection, contracting, and operational implementation. Build and implement scalable distribution frameworks to support pre-launch, launch, and ongoing optimization. Proactively identify and mitigate channel risks while maintaining flexibility to adjust strategy as market conditions evolve. Cross-Functional Leadership Partner closely with Market Access, Patient Services, Finance, Legal, Compliance, and Supply Chain to ensure coordinated and efficient execution. Act as the internal expert on trade and distribution, contributing to broader commercialization and access strategy. Collaborate within a small team of senior commercialization professionals, operating with shared accountability and a hands-on approach. External Partner Management Evaluate, select, and manage specialty pharmacies, specialty distributors, and third-party logistics providers. Lead distribution-related negotiations in partnership with Legal and Finance. Establish clear performance expectations and governance to ensure accountability and high-quality execution from partners. Market Insights &amp; Optimization Monitor industry trends and competitive distribution strategies within dermatology and immunology. Continuously refine channel strategy based on payer behavior, patient journey insights, and provider needs. Leverage data and analytics to inform decisions and drive ongoing optimization. Qualifications 10+ years of experience in biopharmaceutical commercialization, with deep expertise in trade, distribution, and channel strategy. Experience operating in small, agile organizations with limited infrastructure. Comfortable navigating ambiguity and making decisions with imperfect information. Strong understanding of dermatology and/or immunology markets preferred. Launch experience is strongly preferred. Proven experience designing and implementing specialty distribution models in the U.S. Strong cross-functional leadership skills, with the ability to influence without authority. Agile, solutions-oriented leader with a strong bias for action. Hands-on operator who leads by doing, not delegating. Bachelor’s degree required; advanced degree (MBA, PharmD, or similar) preferred. The salary range for this position is $270,000 USD to $320,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is based in South San Francisco. Local candidates (onsite Tues-Thurs) are preferred. Will consider excellent candidates&nbsp;nation-wide if they are willing to travel regularly to South San Francisco. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents 401k match Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO&nbsp; Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp; &nbsp; &nbsp;

Senior Director, Trade Operations

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; Alumis is seeking an experienced Director of Thought Leader Liaison (TLL) with deep expertise in Dermatology. This role is a field-based commercial leadership role responsible for leading a team of field based TLLs, to develop and execute Key Opinion Leader (KOL) engagement strategies for the US launch of envudeucitinib for Psoriasis.&nbsp; The successful candidate will be a key member of the brand marketing team, working across multiple stakeholders at the intersection of marketing, medical, and field execution, with accountability for team leadership, KOL strategy and execution, and strategic insight generation to shape brand strategy. This role will require a deep understanding of medical science, excellent leadership capabilities, and a strong ability to drive the success of cross-functional teams.&nbsp; Key Responsibilities: Leadership &amp; Team Management Build, lead and manage a team of TLL reports with the responsibility for coaching, developing, assessing performance, delegation, prioritization and fostering a collaborative and high performing culture. Collaborate with the Marketing leadership team to align TLL activities with organizational priorities and strategic initiatives. Set the direction and manage the cross functional collaboration and coordination of the TLL team with key stakeholders for development and execution of key brand activities and tactics. Conduct regular performance evaluations, identify skill gaps, and support TLL development through coaching, training, and career growth opportunities. Strategic Planning &amp; Execution Design and implement an engagement strategy in partnership with Marketing and other key stakeholders to guide interactions between the TLL team and KOLs. Oversee the identification, establishment, and maintenance of the TLL thought leader community, ensuring alignment with Medical Affairs and other key stakeholders. Drive development and execution of key strategies and tactics to high standards whilst delivering exceptional customer experiences. Initiates and pursues opportunities for commercial engagement at national and regional conferences, key advocacy or healthcare stakeholder meetings. and represent Alumis at these events. KOL Relationship Management Cultivate strong, long-lasting relationships with existing and new KOLs to gather feedback on market dynamics, competitive landscape, marketing strategy, and tactical execution. Serve as a marketing resource and point of contact for KOLs. Represent the company at scientific congresses, advisory boards, speaker bureau events and other relevant forums to enhance scientific and therapeutic understanding. Compliance &amp; Reporting Ensure all TLL activities are conducted in compliance with regulatory, ethical, and company standards, HIPAA regulations. Provide regular updates to Marketing management on team progress, KOL engagement, and other key initiatives, including metrics on impact and outcomes. Stay abreast of the competitive landscape and emerging trends in dermatology, rheumatology, and neurology, ensuring TLL activities reflect the latest scientific advancements. Qualifications: Experience Minimum of 10 years of experience in TLL or related roles, with leadership experience in managing a team of TLLs. Deep experience in therapeutic area of medical dermatology. In-depth knowledge of medical dermatology, including clinical practice, research, and evolving treatment paradigms. Proven track record of successful relationship-building with KOLs, HCPs, and key stakeholders within the medical community. &nbsp;Experience working in cross-functional teams, with a demonstrated ability to collaborate effectively with medical affairs, clinical, and other business functions. Skills &amp; Competencies Excellent leadership and team management skills, with the ability to inspire and develop a high-performing team. Previous experience working in a leadership role within a biopharmaceutical company or a global pharmaceutical organization. Comfort at presenting team activities to C-suite. Strong communication, presentation, and interpersonal skills, with the ability to engage effectively with internal and external stakeholders. Deep understanding of the pharmaceutical industry, including regulatory and compliance requirements, scientific data dissemination, and account or relationship management. Ability to translate information including scientific, into actionable insights for diverse audiences, including KOLs, healthcare professionals, and internal teams. Strong problem-solving, strategic thinking, analytical and decision-making skills. Agile, solutions-oriented leader with a strong bias for action. Bachelor’s degree required. Travel This position is primarily remote with travel. Willingness to travel extensively (50-75%) as required for KOL engagement, scientific meetings, brand activities and team management activities Regular travel to HQ expected Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.&nbsp;&nbsp;The salary range for this position is $215,000-$260,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents 401k match Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO&nbsp; Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Director of Thought Leader Liaison, US Psoriasis Launch

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;We are seeking an experienced and highly motivated Senior Scientist for the Drug Product Development group who can work in a collaborative and dynamic environment. The scientist in this role is responsible for activities critical to the development of Alumis’ molecules including generation of pre-formulation packages, formulation selection, and manufacturing process development. This primary focus of this role will currently be on solid oral dosage form development but may involve the development of other dosage forms in the future. Responsibilities Hands-on pre-clinical formulation development includes identifying vehicles, excipients, and/or new technologies for poorly water-soluble compounds in support of preclinical PKPD, efficacy, and tox studies. Execute and/or oversee pre-formulation activities including characterization of physicochemical and solid-state properties for investigational small molecules with hands-on instrumental analysis (HPLC/UPLC, DSC, XRPD) and method development. Work effectively with external CDMOs to develop early-stage drug products and oversee production of clinical trial material in support of clinical timelines. Experience in formulation development, process optimization for small molecule solid oral dosage forms including modified-release products includes execute/oversee formulation and manufacturing process development activities. Excellent oral and writing communication skills and flexibility to work in a fast-paced team environment by providing updates (oral and written) clearly and concisely. Support relevant CMC sections for key regulatory filings including INDs and NDAs. Experience in authoring technical reports and regulatory documents (e.g. IND/NDA) is a plus. Comfortable in a fast-paced small company environment. Proactively identify project risks and prepare mitigation and contingency plans. Willing to travel as needed to support ongoing development activities. Education&nbsp; Ph.D. degree in Pharmaceutical Sciences, Chemistry, Engineering or related field with a minimum of 8 years or B.S. or M.S. with a minimum of 10+ years related industrial experience. Alumis Values Elevate Challenge Nurture This position is located in South San Francisco, CA with three (3) to five (5) days a week in lab.&nbsp; We are not considering remote applicants.&nbsp;&nbsp; The salary range for this position is $139,000 USD to $169,000 US annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; Alumis Inc. is an equal opportunity employer.

Senior Scientist, Drug Product Development

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;&nbsp; We are seeking an exceptionally motivated individual to provide leadership and support to global regulatory activities to achieve Alumis’ strategic vision in obtaining worldwide approvals to market our products. The individual will represent Regulatory Affairs and work closely with cross-functional study teams and technical regulatory service providers in accordance with health authority and ICH requirements. In addition to being a key member of our project teams, she/he will provide organizational support as the company and its product development pipeline grow. This role will be reporting to the Director of Regulatory Strategy. ESSENTIAL DUTIES &amp; RESPONSIBILITIES · Serve as the Regulatory Affairs representative for Phase 1 to Phase3 trials, ensuring regulatory activities are evaluated, prioritized and executed to meet global regulatory requirements. · Serve as the Regulatory Affairs representative on assigned study teams and assure the progress of studies by addressing regulatory related queries in support of regulatory approvals. · Lead preparation, review and submission of INDs/CTAs, amendments, review and approval of investigator document packages and manage other regulatory activities of the assigned studies as needed. · Establish and meet timelines for regulatory submissions related to INDs/CTAs, including nonclinical, clinical, and CMC activities, while planning for Phase 1 to 3 trials. · Interact with Contract Research Organization (CRO) Regulatory Affairs counterpart. · Maintain awareness of current regulatory requirements and communicate requirements in support of regulatory approvals. &nbsp; &nbsp; EDUCATION/EXPERIENCE/SKILLS: · Bachelor’s or advanced degree in scientific discipline, with a minimum of 5 years of experience working in drug development in the biopharmaceutical industry and at least 3 years of experience in Regulatory Affairs; immunology or rare disease/ orphan drug development experience desirable. Knowledge/Skills/Abilities: · Direct experience with pharmaceutical global regulatory submissions and contributing to major regulatory filing(s) such as IND/CTA. · Working knowledge of FDA regulations and practices and ICH guidance as well as strong knowledge of global health authority regulations and practices. · Demonstrated experience in successfully leading assigned activities within cross-functional teams. · Excellent verbal and written communication skills. · Collaborative, analytical and interpretative skills that enable review and compilation of reports and other documents used in regulatory planning and submissions. · Ability to work with minimal supervision, to set priorities to meet timelines, to motivate and influence others, prior management experience a plus. · Responsibilities may require a work schedule that may include working outside of “normal” work hours, to meet business demands. The salary range for this position is $165,000 USD to $195,000 USD annually paid hourly per contract. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;

Senior Manager Regulatory Affairs (contract)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; &nbsp; The Director, Field Medical Excellence and Training will be responsible for overseeing and advancing key field-based initiatives that inform or support Medical Affairs strategies, and developing and executing a comprehensive medical training programs across therapeutic areas. The role demands an individual who combines experience in a fast-paced environment with scientific knowledge, excellence in field medical execution, and strong educational and operational leadership. Key Responsibilities: · Strategic Leadership: · Lead and drive the development, implementation, and measurement of the effectiveness of field-based initiatives to inform or support launch and new product strategies. · Assist with development and implement frameworks for field effectiveness, including KPIs, activity metrics, and qualitative impact measures. · Support field medical launch readiness (territory design, targeting, resource planning) &nbsp; · Training &amp; Capabilities: · Partner with Medical Training to identify capability gaps and support ongoing development of the field medical team · Create tools and resources to improve field execution (e.g., engagement guides, scientific narratives) · Fostering a team culture of accountability and develop a proactive approach to growing skillsets &nbsp; · Medical Insights: Collaborate with Medical Affairs Leadership to develop and drive strategies to collect, analyze, and integrate valuable medical insights that inform strategic decisions. · Field Resources: Assess field resources to ensure a high standard of tactical execution aligned with Medical Strategy. · Cross-functional Collaboration: Collaborate with other functional areas such as Clinical Development, Commercial, Compliance and Regulatory to ensure alignment and integration of medical excellence within the broader organizational strategy. &nbsp; Qualifications: · Education: Advanced degree in life sciences (PhD, PharmD, masters or equivalent); degree or certificate in training or education a plus · Experience: Minimum of 7+ years of Medical Affairs expereince, including 5 yrs in Field Medical. Proven experience in training Field Medical personnel and managing field-based initiatives. · Leadership Skills: Must have track record of effectively leading without authority, a strong commitment to teamwork, coaching or mentoring, and emotional intelligence. · Operational Expertise: Strong experience in utilizing systems to educate and manage field-based initiatives. · Strategic Thinking: Ability to develop and implement strategic initiatives that drive organizational goals and enhance the impact of Medical Affairs functions. · Strong Communication: Excellent communication and interpersonal skills, with the ability to engage and influence internal stakeholders at all levels. &nbsp; Primarily US remote field-based with travel. ~25% travel required to professional conferences, internal meetings, and field co-rides, including some weekends The salary range for this position is $220,00 to 265,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices degree and background. &nbsp; Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Director, Field Medical Excellence and Training

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; This role will serve as a strategic and operational partner to the Vice President of Medical Affairs and Medical leadership team, and is responsible for ensuring that medical capabilities, processes, systems, and execution models are efficient, compliant, scalable, and aligned with Alumis’ growth strategy. The Senior Director, Medical Strategy and Operations, will be responsible for advancing key initiatives aimed at optimizing and showcasing the impact of the Medical Affairs team. This is a hands-on position that includes driving medical strategic initiatives, enhancing the Medical Affairs systems, supporting critical medical insights processes, and developing innovative solutions to measure and report on medical affairs performance and impact. The role demands an individual who combines scientific knowledge with strong operational leadership to thrive in a fast-paced, agile environment to elevate our medical affairs capabilities. Key Responsibilities: · Strategic Leadership: Lead and drive the development and execution of initiatives that elevate the strategic and operational effectiveness of the Medical Affairs team in a consistent and scalable manner. · Medical Affairs Systems Optimization: o Oversee the design, implementation, and optimization of our Medical Affairs systems to improve internal efficiencies, engagement and communications with key opinion leaders (KOLs), healthcare providers, and other relevant stakeholders. o Lead continuous improvement initiatives to enhance efficiency, quality, and compliance across the Medical function. o Implement best practices for operational metrics, KPIs, dashboards, and reporting to support data-driven decision-making. · Medical Insights: Collaborate with Medical Affairs Leadership to collect, analyze, and integrate valuable medical insights that inform strategic decisions and optimize the impact of our medical programs. · Content Management: Serve as Medical Affairs content owner through review and approval process for external-facing materials. · Cross-functional Collaboration: Collaborate with other functional areas such as Clinical Development, Marketing, Market Access, Commercial, Analytics, Compliance, and Regulatory to ensure alignment and integration of medical excellence within the broader organizational strategy. · Guidance and SOP Development: Leverage expertise to develop guidance documents and SOPs to foster consistency, clarity, and accountability across Medical Affairs. · Planning, Budgeting &amp; Resource Management o Lead medical annual planning, forecasting, and budget management. o Optimize headcount planning, vendor strategy, and external spend to maximize impact and efficiency. o Provide transparency and insights into medical investments and their impact. Qualifications: · Experience: Minimum of 10 years in Medical Affairs leadership. Proven experience in managing and optimizing medical operations, systems, content, and medical insights. Experience in a fast-paced, small biotech environment a plus &nbsp; Education: Advanced degree (PhD, MD, MBA, PharmD or similar) · Leadership Skills: Exceptional leadership abilities with a demonstrated ability to manage cross-functional teams and drive change across complex medical operations. Must have track record of effectively leading without authority · Operational Expertise: Strong experience in developing and managing Medical Affairs dashboards and other qualitative outcomes to measure impact and performance. · Strategic Thinking: Ability to develop and implement strategic initiatives aligned cross-functionally that drive organizational goals and enhance the impact of Medical Affairs functions. · Strong Communication: Excellent communication and interpersonal skills, with the ability to engage and influence stakeholders at all levels, both internally and externally. The salary range for this position is $265,00 to 310,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices degree and background. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Senior Director, Medical Strategy and Operations

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The&nbsp;small&nbsp;molecule&nbsp;CMC&nbsp;team&nbsp;is&nbsp;seeking&nbsp;highly&nbsp;motivated&nbsp;Sr.&nbsp;Scientist&nbsp;I&nbsp;of&nbsp;Analytical&nbsp;Development&nbsp;to&nbsp;help&nbsp;build&nbsp;our&nbsp;dynamic&nbsp;small&nbsp;molecule CMC&nbsp;group&nbsp;at&nbsp;Alumis.&nbsp;The successful candidate will help to&nbsp;support&nbsp;the&nbsp;analytical development&nbsp;and quality control&nbsp;activities&nbsp;from the&nbsp;preclinical&nbsp;phase through late-stage clinical development. Having&nbsp;analytical development&nbsp;expertise&nbsp;and experience in working with CMOs/CTLs,&nbsp;coupled with&nbsp;thorough&nbsp;understanding of the associated quality&nbsp;and regulatory&nbsp;awareness are key assets.&nbsp; RESPONSIBILITIES&nbsp; Support&nbsp;development, validation,&nbsp;and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs&nbsp;&nbsp; Execute&nbsp;and/or&nbsp;support the in-house method development&nbsp;activities&nbsp;using&nbsp;UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and techniques&nbsp;for Phase 1 to late-stage drug development&nbsp; Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports&nbsp;&nbsp; Trend&nbsp;stability and release data using statistical methods&nbsp; Assist&nbsp;in investigation for various non-conformance events at CMOs/CTLs&nbsp; Collaborate with&nbsp;CMC team,&nbsp;QA and CMOs/CTLs&nbsp;towards&nbsp;timely&nbsp;generation and approval of documents&nbsp; Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams&nbsp; Author&nbsp;technical reports and documents in support of regulatory filing&nbsp; Assist&nbsp;in preparation of CMC documents for regulatory submissions (IND, IMPD, and/or NDA)&nbsp; THE IDEAL&nbsp;CANDIDATE&nbsp; BS/MS&nbsp;in&nbsp;chemistry&nbsp;or pharmaceutical sciences&nbsp;with&nbsp;5+&nbsp;years&nbsp;of&nbsp;experience&nbsp;in&nbsp;analytical development&nbsp; Experience with analytical techniques for small drug molecules and oral solid formulations&nbsp;required, including UPLC/HPLC, LC-MS, KF, dissolution testing, IR, particle size analysis, and solid-state characterization techniques&nbsp; Proven&nbsp;track record&nbsp;in applying analytical techniques to solve challenging problems&nbsp; Experience in working with CMOs and CTLs&nbsp; Experience in early to late-stage drug development&nbsp; Strong organizational and communication skills&nbsp; Comfortable in a fast-paced small company environment and&nbsp;a&nbsp;strong team&nbsp;player&nbsp; Experience and&nbsp;knowledge&nbsp;in&nbsp;ICH,&nbsp;cGMP&nbsp;and regulatory requirements&nbsp;&nbsp; This position is located in South San Francisco, CA. At this time, we are not considering fully remote applicants. The salary range for this position is $112,000 USD to $135,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp;

Senior Scientist I Analytical Development

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis&nbsp;Inc is a precision medicines company with&nbsp;the&nbsp;mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer – our goal is to fundamentally change the outcomes for these patients.&nbsp; We are seeking a Data Science leader within Statistical Programming to advance analytical insights across clinical development while supporting high-quality, submission-ready deliverables.&nbsp;You will employ modern data science methods and tools such as machine learning, generative AI, and agentic AI to strengthen statistical programming and elevate analytical insight generation.&nbsp;You will contribute to both clinical data science (enhancing analyses, insights, and submissions) and operational/enterprise analytics (improving efficiency, scalability, and decision-making across Biometrics).&nbsp;&nbsp; Depending on level, this individual will&nbsp;operate&nbsp;as a hands-on study/program contributor (Senior Manager) or a program-level leader influencing strategy and cross-functional execution (Associate Director).&nbsp; &nbsp; Essential&nbsp;Responsibilities&nbsp; Clinical Evidence Generation, Analytical Insights, and&nbsp;Regulatory Engagement&nbsp;&nbsp; Develop and deliver data science analyses to support clinical development, regulatory submissions, publications, and&nbsp;exploratory&nbsp;analyses.&nbsp; Partner with Biostatistics to support innovative analyses (e.g., simulations, external controls, RWE integration,&nbsp;predictive&nbsp;analytics using ML/GenAI models).&nbsp; Ensure alignment between exploratory analytics and CDISC-based submission deliverables;&nbsp;maintain&nbsp;documentation for inspection readiness.&nbsp; Support analysis of emerging data types (e.g., biomarkers, digital endpoints, real-world data, text, imaging), ensuring interpretability and quality.&nbsp; Contribute to responses to regulatory queries and preparation of submission materials involving advanced analytics.&nbsp; Technical&nbsp;Execution&nbsp;&amp;&nbsp;Innovation&nbsp; Develop and&nbsp;maintain&nbsp;analysis&nbsp;workflows using SAS and/or open-source tools (R/Python), balancing innovation with compliance.&nbsp; Build reusable tools, macros,&nbsp;templates&nbsp;and pipelines&nbsp;to improve efficiency, reproducibility, and scalability.&nbsp; Contribute to reproducible&nbsp;analysis&nbsp;pipelines (e.g., version control,&nbsp;data&nbsp;engineering&nbsp;and pipeline automation).&nbsp; Support development of dashboards and visualizations (e.g., Shiny, Plotly) to communicate insights effectively.&nbsp; Apply data science methods to improve study execution and operational insights (e.g., enrollment trends, data quality signals, feasibility).&nbsp; Cross-Functional Collaboration&nbsp; Partner with Biostatistics, Data Management, Clinical Operations, and other stakeholders to support study and program deliverables.&nbsp; Participate in the review of key study documents (e.g., SAPs, CRFs, DMPs, database specifications) for programming and analysis alignment.&nbsp; Serve as a point of contact for programming and data science activities with internal teams and CRO partners.&nbsp; Translate analytical outputs into clear, actionable insights for both technical and non-technical audiences.&nbsp; Process,&nbsp;Quality, &amp;&nbsp;Compliance&nbsp; Ensure all programming and data science deliverables meet regulatory, industry, and company standards (e.g., CDISC,&nbsp;GxP, 21 CFR Part 11).&nbsp; Contribute to the development and continuous improvement of programming and data science standards, processes, and SOPs.&nbsp; Stay current&nbsp;on&nbsp;evolving regulatory&nbsp;movement&nbsp;related to data science,&nbsp;AI/ML, and analytics in drug development.&nbsp; Leadership&nbsp;and Scope Differentiation&nbsp;&nbsp; Senior Manager:&nbsp; Lead data science activities at the study level;&nbsp;operate&nbsp;as a hands-on contributor delivering analyses and tools. Associate Director:&nbsp; Provide program-level oversight across multiple studies; influence data science strategy and cross-functional alignment.&nbsp; Contribute to shaping data science standards, tools, and longer-term capabilities within Statistical Programming.&nbsp; Mentor junior team members and guide CRO partners.&nbsp; The Ideal Candidate&nbsp; Strong&nbsp;experience&nbsp;in SAS,&nbsp;R or Python&nbsp;for data analysis and visualization.&nbsp; Experience in Data Science methods and tools: Machine Learning models and model development&nbsp;lifecycle, GenAI/Agentic AI application development as a plus&nbsp; Experience supporting clinical development and regulatory submissions in a pharma/biotech or CRO setting.&nbsp; Hands-on experience with CDISC standards (SDTM,&nbsp;ADaM) and integration with exploratory analytics.&nbsp; Experience working with diverse data types (clinical, biomarker, or real-world data)&nbsp;and data engineering pipeline development.&nbsp; Experience&nbsp;with reproducible research practices (e.g., version control, structured workflows).&nbsp; Ability to analyze complex datasets and translate findings into actionable insights.&nbsp; Strong communication&nbsp;and collaboration skills across technical and non-technical stakeholders.&nbsp; Detail-oriented with a strong commitment to quality and accuracy.&nbsp; Therapeutic experience in autoimmune/immunology is a plus.&nbsp; In addition, for Associate Director level:&nbsp; Experience influencing program-level&nbsp;strategy&nbsp;across multiple studies or indications.&nbsp; Demonstrated ability to drive cross-functional alignment and contribute to analytical strategy.&nbsp; Experience mentoring team members and overseeing CRO/vendor deliverables.&nbsp; Exposure to&nbsp;advanced analytics approaches (e.g., causal inference, simulations, RWE integration) in a regulated environment.&nbsp; Education &amp; Experience&nbsp; Senior Manager:&nbsp; Bachelor’s degree (or equivalent) with 8+ years of experience, or&nbsp;Master’s&nbsp;with 6+ years&nbsp; Associate Director:&nbsp; Bachelor’s degree (or equivalent) with 10+ years of experience, or&nbsp;Master’s&nbsp;with 8+ years&nbsp; &nbsp; This role is located in South San Francisco, CA, with an on-site presence expected Tuesday through Thursday. Remote candidates may remain off-site but should be willing to travel regularly for team collaboration. Alumis Inc. is an equal opportunity employer. The salary range for this position is Senior Manager: $180,000 - $200,000 annually and Associate Director: $200,000 - $220,000 annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis&nbsp;compensation packages include generous stock option grants for all employees as well as an annual bonus program. Other benefits include: Health insurance premiums paid at 90% for&nbsp;employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and&nbsp;a kitchen&nbsp;stocked with&nbsp;yummy&nbsp;snacks and drinks! We are a hard-working, collaborative team on a mission to transform&nbsp;patient’s&nbsp;lives-- and we aspire to elevate, challenge and nurture one another along the way.

Associate Director/Senior Manager, Data Science (Statistical Programming)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; &nbsp; We are seeking an experienced Regional Director of Medical Science Liaisons (MSLs) with expertise in medical dermatology. The successful candidate will be responsible for leading and overseeing MSLs, ensuring the effective dissemination of scientific and clinical information, building relationships with key opinion leaders (KOLs), and supporting the strategic goals of the Medical Affairs organization. This role will require a deep understanding of medical science, excellent leadership capabilities, and a strong ability to drive the success of cross-functional teams. We will be seeking one individual for the Western US, one Central, and one for the Eastern US. &nbsp; Responsibilities: Field-based Leadership of Regional DPEGs and IDNs Serve as primary point of contact with the clinical leaders, educational leaders, and C-suite executives of Dermatology Private Equity-backed Groups, DPEGs, to build trusting professional relationships Develop deep understanding of DPEG structures, performance metrics, and educational needs Develop cross-functional engagement strategy to build the groundwork for launch Co-create data-driven value proposition to improve patient outcomes Leadership &amp; Team Management: Lead, mentor, and manage a team of MSLs, fostering a collaborative, high-performing, and scientifically rigorous culture. Provide guidance on the development and execution of territory plans, objectives, and key performance indicators (KPIs) for each MSL. Conduct regular performance evaluations, identify skill gaps, and support MSL development through coaching, training, and career growth opportunities. Collaborate with the Medical Affairs leadership team to align MSL activities with organizational priorities and strategic initiatives. Strategic Planning &amp; Execution: Contribute to the development of MSL tactics in line with corporate and therapeutic area goals. Drive the execution of MSL tactics within assigned region. Ensure MSLs are equipped with the latest scientific data and clinical information, and support their integration into both regional and national-level initiatives. Scientific Exchange &amp; KOL Relationship Management: Cultivate strong, long-lasting relationships with KOLs, healthcare providers, academic researchers, and key stakeholders through active field engagement in the region. Serve as a scientific resource and point of contact for KOLs to address inquiries regarding the company’s pipeline, products, and scientific advancements. Represent the company at scientific congresses, advisory boards, and other relevant forums to enhance scientific and therapeutic understanding. Cross-Functional Collaboration: Provide strategic input into the development of clinical trials, publication plans, and other medical activities by leveraging field insights and customer feedback. Collaborate with the Medical Affairs leadership to ensure appropriate deployment of MSL resources to support clinical, regulatory, and commercial objectives. Compliance &amp; Reporting: Ensure all MSL activities are conducted in compliance with regulatory, ethical, and company standards, including GxP (Good Clinical Practice) and HIPAA regulations. Provide regular updates to MA management on team progress, KOL engagement, and other key initiatives, including metrics on impact and outcomes. Stay abreast of the competitive landscape and emerging trends in dermatology, rheumatology, and neurology, ensuring MSL activities reflect the latest scientific advancements. &nbsp; Qualifications: Education: o PhD, PharmD, MD, or other advanced degree in a relevant scientific discipline (e.g., Biology, Pharmacology, Medicine). Experience: o Minimum of 10 years of experience in Medical Affairs or related scientific roles, with leadership experience in managing a team of MSLs or scientific professionals. o In-depth knowledge of medical dermatology, including clinical practice, research, and evolving treatment paradigms. o Proven track record of successful relationship-building with KOLs, HCPs, and key stakeholders within the medical community. o Experience working in cross-functional teams, with a demonstrated ability to collaborate effectively with commercial, clinical, regulatory, and other business functions. Skills &amp; Competencies: o Excellent leadership and team management skills, with the ability to inspire and develop a high-performing team. o Strong communication, presentation, and interpersonal skills, with the ability to engage effectively with internal and external stakeholders. o Deep understanding of the pharmaceutical industry, including regulatory and compliance requirements, scientific data dissemination, and product lifecycle management. o Ability to translate complex scientific information into actionable insights for diverse audiences, including KOLs, healthcare professionals, and internal teams. o Strong problem-solving, strategic thinking, and decision-making skills. Travel: o Willingness to travel extensively (50-75%) as required for KOL engagement, scientific meetings, and team management activities. Preferred Qualifications: · Experience in therapeutic areas of medical dermatology. · Previous experience working in a leadership role within a biopharmaceutical company or a global pharmaceutical organization. · Familiarity with clinical trial processes, publication planning, and scientific communication in a corporate environment. The salary range for this position is $220,00 to 260,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background. &nbsp; This position is primarily remote with travel. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Role Summary The Business Partner, IT Commercial is a director-level role responsible for aligning IT capabilities with the strategic and operational needs of the commercial organization. This individual serves as the primary technology partner for pre-commercial and commercial functions — including Sales, Marketing, Market Access, and Medical Affairs — translating business requirements into scalable IT solutions during a critical phase of company growth. Operating within a small to medium-sized biotech or pharmaceutical environment, this role requires both strategic vision and hands-on execution. The Business Partner will lead the evaluation, implementation, and optimization of commercial systems (CRM, ERP, data &amp; analytics platforms) while ensuring readiness for launch and beyond. Key Responsibilities Commercial Systems Leadership Own the IT strategy and roadmap for commercial-facing systems, including CRM (e.g., Veeva, Salesforce), ERP, contract management, and master data management (MDM) platforms. Lead end-to-end delivery of commercial technology initiatives — from requirements gathering and vendor selection through implementation, validation, and go-live. Ensure systems are configured to support pre-commercial activities such as field force deployment, sample management, HCP/HCO data management, and promotional materials tracking. Business Partnership Serve as the primary IT liaison for Commercial, Market Access, Marketing, and Sales Operations stakeholders. Partner with business leaders to identify technology gaps, define requirements, and prioritize the IT portfolio in alignment with launch timelines and commercial goals. Translate complex technical concepts into clear business value for non-technical audiences. Commercial Strategy Partner with commercial leadership to shape the long-term IT strategy that enables go-to-market planning, competitive positioning, and portfolio decision-making. Support business intelligence and reporting capabilities that provide insights into market trends, sales performance, and customer engagement. Marketing Technology Oversee IT solutions supporting multichannel marketing execution, including digital engagement platforms, content management systems (CMS), and marketing automation tools. Ensure integration between marketing platforms and CRM systems to enable coordinated customer engagement across channels. Market Access Support technology solutions for payer and account management, including contract management, formulary tracking, and gross-to-net analytics platforms. Partner with Market Access stakeholders to ensure data flows and reporting capabilities support reimbursement strategy and pull-through activities. Medical Affairs Enable IT solutions for Medical Affairs functions, including medical information platforms, KOL engagement tracking, scientific exchange tools, and congress/event management. Ensure Medical Affairs systems meet compliance and regulatory requirements for appropriate off-label and on-label scientific communication. Pre-Launch &amp; Launch Readiness Drive IT readiness activities in support of product launch, including system build-out, user acceptance testing (UAT), training, and hypercare support. Collaborate cross-functionally with Regulatory, Legal, Compliance, and Finance to ensure commercial systems meet applicable requirements (e.g., PDMA, OIG guidelines, data privacy regulations). People Leadership Lead, mentor, and develop a team of IT professionals supporting commercial functions, fostering a culture of accountability, collaboration, and continuous improvement. Define roles, responsibilities, and performance expectations; support career development and succession planning within the team. Vendor &amp; Stakeholder Management Manage relationships with third-party vendors, system integrators, and managed service providers supporting commercial technology. Negotiate contracts and SLAs; hold vendors accountable to delivery commitments and quality standards. Governance &amp; Compliance Ensure commercial systems adhere to IT governance, data integrity, and security standards. Required Qualifications Bachelor's degree in Information Technology, Computer Science, Life Sciences, or a related field; advanced degree preferred. 10+ years of IT experience, with at least 5 years in a business partner, IT lead, or equivalent role supporting commercial functions in biotech or pharma. Demonstrated experience supporting pre-commercial or launch-stage activities at a small to mid-sized life sciences company. Deep expertise with commercial systems such as Veeva CRM, Salesforce, SAP, or equivalent platforms. Strong understanding of pharmaceutical commercial operations, including field force, commercial strategy, marketing, market access, and medical affairs. Hands-on experience delivering IT solutions across Commercial Strategy, Marketing Technology, Market Access, and Medical Affairs functions, with a clear understanding of the business workflows and data needs unique to each. Proven ability to manage multiple concurrent initiatives in a fast-paced, resource-constrained environment. Proven track record of managing and developing direct reports, including setting goals, providing coaching, and building high-performing teams in a dynamic environment. Experience managing external vendors, system integrators, and managed service providers — including contract negotiation, performance management, and holding partners accountable to delivery commitments and SLAs. Preferred Qualifications Experience supporting the commercial launch of one or more pharmaceutical or biologic products. Familiarity with specialty pharma or rare disease commercial models. Knowledge of data privacy regulations (HIPAA, GDPR) and industry compliance standards (PDMA, OIG). Experience with master data management (MDM) and data governance in a commercial context. Familiarity with commercial analytics tools (e.g., IQVIA, Symphony Health data integrations, Tableau, Power BI). PMP, ITIL, or equivalent certification. Alumis Inc. is an equal opportunity employer. The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Remote candidates will be considered on a case-by-case basis. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp; &nbsp; &nbsp;

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