4D Molecular Therapeutics is a leading biotechnology company specializing in gene therapy, founded in 2013. The company is at the forefront of developing innovative therapies using cutting-edge technology to address genetic diseases. 4D Molecular Therapeutics is revolutionizing the field of medicine with its groundbreaking approach to gene therapy, offering promising solutions for patients with previously untreatable conditions.

Sr. IT Support Engineer

Vice President, Late-Stage Clinical Development

Associate Director - External Engagement

Senior Medical Director - Ophthalmology (Retina) Remote

Sr. Maintenance Technician

VP, Medical Affairs

Associate Director, Medical Affairs Operations

Sr. Manager, Audit Program

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY Reporting to the Chief Medical Officer the VP Clinical Development, Ophthalmology provides strategic and operational leadership for the global development of ophthalmic genetic medicines in Drug Development. We seek an experienced physician to play a critical role at 4DMT as we spearhead the introduction of the first intravitreally delivered genetic medicines for the treatment of the most common causes of irreversible blindness. The VP, Clinical Development, ophthalmology will be the primary point person for medical oversight of clinical studies with responsibilities to include medical monitoring, review and interpretation of clinical trial data, clinical trial design, protocol development, and drafting of key clinical documents such as protocol, CSR, briefing package, IND, NDA, BLA, etc. This role will be responsible for timely execution of deliverables in close collaboration with relevant internal and external partners. MAJOR DUTIES &amp; RESPONSIBILITIES: Serve as the primary medical monitor for multiple ophthalmology clinical trials, providing expert oversight of patient safety, data integrity, and protocol adherence throughout study execution. Direct and mentor a team of medical monitors, ensuring high standards of medical oversight and data review, while maintaining personal accountability for real-time monitoring activities and timely delivery of critical clinical trial outputs Provide medical leadership for cross-functional internal workstreams including pharmacovigilance, biostatistics, clinical operations, regulatory affairs, etc. Provide oversight and lead teams responsible for development plans, study protocols, amendments, ICFs, IBs, INDs, annual reports, CSRs, regulatory response documents and other regulatory submissions or documents as appropriate Collaborate closely with Clinical Operations and be accountable for clinical trial conduct and timelines for associated key deliverables. Keep up to date with compliance, SOPs and adhere to ICH, GCP, and relevant regulatory guidelines. Provide medical leadership for internal audits and regulatory inspections. Assist in preparation of materials for Advisory Board meetings, BOD meetings, etc Represent 4DMT and Lead interactions and collaborations with potential partners Represent the Ophthalmology Therapeutic Area with key external stakeholders, including patients and patient advocacy groups, external experts, investors, and the ophthalmic and biotech business communities Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; M.D. Degree Clinical training in Ophthalmology Retina fellowship training a plus Board Certification (or equivalent) &nbsp; Experience:&nbsp; Minimum of 10 years of biopharma industry experience in drug development Phase 3 experience in retinal disease (s) Experience with NDA, BLA or MAA submission(s). Drug approval(s) a plus. Experience with gene therapy, other areas of Drug Development and commercialization is a plus Other Qualifications/Skills:&nbsp; Strong interpersonal skills and high emotional coefficient Highly effective written and verbal communication skills Excellent analytical, problem-solving and strategic planning skills. Up to date understanding of the ophthalmic competitive landscape with a focus on retina Prior Clinical Trial experience in Retina Experience in participating or leading global regulatory interactions Ability to understand and translate complex data to key messages Ability to thrive in a fast-paced environment. Proven ability to prioritize effectively Proven ability to plan and conduct clinical trials ensuring high-quality trial execution and results within established timelines; demonstrated track record in working effectively in cross-functional teams and work streams (pharmacovigilance, biostatistics, clinical operations, and regulatory. Track record of thinking strategically and executing to strategy Demonstrated success in influencing colleagues and senior leaders in various departments. Experience building and leading teams and driving engagement in a matrixed environment.&nbsp; Attention to detail, internal drive to generate high-quality work, and sense of passion and urgency to achieve team and program goals. Able to ensure accountability Able to manage conflict Comfortable managing ambiguity Strong clinical and scientific knowledge of ophthalmology (and retinal disease in particular) Track record of developing talent Record of cultivating and managing internal and external cross-functional collaborations. Demonstrates high integrity. Experience in successfully presenting and interacting with the Ophthalmic Retina Community and regulatory authorities in US, EU and APAC Integrated understanding of FDA, EMA, ICH, and GCP guidelines. Prior interactions with FDA and EMA regulatory agencies is desirable. Travel Domestic and Internationally: 20% &nbsp; Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $380,000/yr - $433,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: relevant work experience, skills, and years of experience &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Vice President, Clinical Development, Ophthalmology

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryPost job description here without company intro or disclaimer.4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Quality Systems

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: &nbsp; In this position, you’ll work closely with HR leadership and the team to ensure HR operations run smoothly, compliantly, and with a focus on continuous improvement. The Manager, HR Operations &amp; Systems will own core HR processes and compliance requirements while also playing a major role in the execution of key HR programs, including performance management, talent acquisition, learning &amp; development, and employee engagement. This role is responsible for maintaining accurate employee data, stewarding HR systems, driving automation and efficiencies, and delivering analytics that provide insights into workforce trends. This role helps ensure both the HR team and the broader organization are set up for success. &nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; HR OPERATIONS: Own and continuously improve HR operations processes (onboarding, offboarding, employee changes, documentation, records management). Maintain and update SOPs to ensure compliance and effectiveness. Partner with Finance, IT, and Payroll to ensure timely and accurate processing of employee data and changes. Serve as point of contact for HR service requests, escalating as needed. Regularly evaluate HR operations to identify opportunities for simplification, standardization, and improved employee experience. &nbsp; HR COMPLIANCE: &nbsp; Own compliance activities across HR, including policy administration, record retention, and regulatory reporting. Ensure HR processes and documentation meet requirements of SOX, D&amp;I, federal/state laws, and other regulations applicable to a publicly traded company. Conduct audits of employee files, HR data, and HR processes to ensure accuracy and compliance. Partner with Finance, IT, and external vendors on compliance-related audits. Monitor and integrate new regulations and best practices into HR policies, processes, and the employee handbook. &nbsp; HR TECHNOLOGY: &nbsp; Administer current HR systems, including user access, permissions, and documentation. Ensure HR data accuracy, integrity, and compliance with SOX controls, data privacy, and record retention requirements. Partner with IT and vendors to maintain existing tools, evaluate effectiveness, and make incremental improvements where needed. Provide user support and training for HR systems to ensure adoption and consistency. Drive automation and process efficiencies within HR operations Identify areas of improvement with current HR systems to optimize utilization and efficiency through enhancements and integration of different tools. Explore and evaluate AI-powered HR technologies to automate tasks and improve data analysis, collaborating with IT and HR partners to pilot solutions, monitor effectiveness, and recommend scalable integration. &nbsp; &nbsp; HR PROGRAMS &amp; ANALYTICS: &nbsp; Lead the operational and systems aspects of HR programs throughout the year, including performance management, talent acquisition processes, learning &amp; development, and employee engagement initiatives. Partner with HR leadership and program owners to coordinate timelines, communications, and execution steps to ensure successful delivery. Train HR team members and employees on how to navigate and use HR systems and resources effectively. Maintain accurate program documentation and monitor utilization to evaluate effectiveness. Develop and deliver HR analytics and reporting that provide insights into workforce trends, headcount, and program outcomes to inform decision-making. Continuously evaluate HR programs and processes to identify opportunities for improvement and alignment with organizational goals. &nbsp; &nbsp; QUALIFICATIONS: &nbsp; Education: Bachelors required &nbsp; Experience: &nbsp; 6+ years of progressive HR experience, with strong emphasis on HR operations, systems, and compliance. 3+ years of experience managing HR Operations is preferred. Experience supporting Sox compliance for a publicly traded company. Experience with one or more of the following tools a plus: Greenhouse Recruiting, ChartHop, Leapsome, Nectar. &nbsp; Other Qualifications/Skills:&nbsp; Hands-on experience with ADP Workforce Now (maintenance, data integrity, user support). Strong knowledge of HR compliance requirements, record retention, and reporting. Demonstrated ability to manage and improve HR operations processes. Proficiency in Excel, PowerPoint, and HR reporting. Highly organized with strong attention to detail and documentation skills. Excellent written and verbal communication; able to partner effectively across teams. Customer-service orientation with ability to balance employee experience and compliance requirements. &nbsp; Travel: 0-10% &nbsp; Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $135,000/yr - $165,000/yr &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Manager, HR Operations & Systems

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Senior Director, Medical Affairs, Ophthalmology will contribute to the development and execution of the medical affairs strategy in Ophthalmology. This role will collaborate with clinical development, clinical development operations, scientific communications, external engagement, biometrics, data management, regulatory affairs, drug safety, commercial, and alliance partners. The Senior Director will develop and/or substantially contribute to the implementation of the portfolio strategy and life cycle management planning across indications. The successful candidate will be responsible for cross-functional communication and collaboration across the organization to ensure the execution of global medical affairs strategy across all geographic regions ensuring a cohesive approach for the franchise. This role will lead medical affairs activities ensuring partnership within the team (medical strategy, scientific communications and publications) and across all key Medical Affairs functions (Medical Excellence, HEOR, Field Medical, Medical Information) to ensure alignment and one 4DMT approach. This role will also be the key medical affairs lead for scientific and clinical training initiatives. Reporting to the VP, Medical Affairs, this individual contributor role will serve as a subject matter expert to internal and external stakeholders. Depending on location, this role may be fully remote or hybrid. *Experience in retinal disease is required as well as strong Phase III study support and launch preparedness. MAJOR DUTIES &amp; RESPONSIBILITIES: Assist in development of the medical strategy for entry into new indications and across indications ensuring this fits within the overall company strategy and maintaining cross functional alignment. Deliver on critical identified milestones. Provide input for cross functional partners including clinical development and commercial to ensure that there is a strong medical voice represented. Demonstrate strategic thinking to translate medical/clinical insights of treatment paradigms into growth opportunities, while driving competitive advantage. Act as scientific reviewer, contribute to company sponsored medical affairs research programs and external research, and lead the creation of a robust scientific education plan for healthcare professionals and other stakeholders as well as internal for global medical training, field medical leadership across all regions and HEOR. Build external relationship network for existing and new indications to help drive trial enrollment, launch prep, and gain advice. Provide direction into publication planning and review, medical backgrounders, FAQ and standard responses, internal training approach, and data dissemination. Develop full thought leader engagement strategic approach and ensuing plan and provide insight to the cross functional medical engagement plans. Deliver high quality educational presentations internally and externally, as required. Ensure a comprehensive and synergistic approach by collaborating across Medical Affairs, Regions, and other functions including Commercial and Development. Operate in a fully compliant manner in all internal and external interactions. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS:&nbsp; Education:&nbsp; Advanced degree required (PharmD/PhD/OD/MD) or equivalent degree with relevant therapeutic specialty in the pharmaceutical industry, community, academic or hospital environment required. Direct clinical experience in ophthalmology (MD/OD) preferred. Experience:&nbsp; 7+ years of medical affairs experience in the pharmaceutical industry, academia, or equivalent. Deep ophthalmology therapeutic area expertise strongly preferred. Ability to interact externally and internally to support a global scientific and business strategy. Extensive knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials, and experience in development of clinical strategy and the design of study protocols. &nbsp; Other Qualifications/Skills:&nbsp; Must possess excellent oral and written English communication skills. Ability to exercise judgment and address complex problems and create solutions across multiple projects. Pre-launch preparation and launch experience strongly preferred Retina experience required, candidates with existing relationships within the retina community strongly preferred Global medical affairs experience a strong plus Travel: up to 60%, domestic and international Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $276,000/yr - $337,000/yr4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Sr. Dir, Medical Affairs

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; &nbsp; The Senior Medical Director is accountable for the design, execution, and analysis of clinical trials in the Ophthalmology Therapeutic Area.&nbsp; &nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES:&nbsp; Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.&nbsp; Serves as medical monitor on clinical studies. Serves as the primary clinical author of development plans, study protocols, amendments, ICFs,&nbsp; IBs, INDs, annual reports, CSRs, regulatory submissions / correspondence, and project-related documents. Accountable for the accuracy of all medical content of such documents. Works with the research organization and the portfolio management team to identify and support new project opportunities. Collaborates to identify program risks, and to create and implement mitigation strategies Other duties as assigned &nbsp; QUALIFICATIONS:&nbsp; &nbsp; Education:&nbsp; Medical Degree (M.D.) Residency training in Ophthalmology with a preference for subspecialty training in retina Board certification a plus Retina fellowship training a plus Experience:&nbsp; 8+ years of clinical ophthalmology research in the biopharmaceutical industry Experience with Phase 3 retina clinical trials Experience with gene therapy a plus. Experience in other phases (Phase 1, 2, 4) of clinical research a plus. Experience with NDA/BLA/MAA submission a plus. Experience writing clinical research protocols and acting as a medical monitor&nbsp; Experience in data analysis, data interpretation, and medical writing &nbsp; Other Qualifications/Skills:&nbsp; Knowledge of ICH-GCP and FDA regulatory guidelines. Knowledge of international regulatory guidelines a plus. Effective written and verbal communication skills, including public speaking &nbsp; Travel: 15% (3 days/month) &nbsp; Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). &nbsp; Base salary compensation range: $315,000/yr - $390,000/yr4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Sr. Medical Director

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; The incumbent will focus on providing strategic input and technical expertise on statistical methodology to support the research and development organization for assigned projects. They will participate as active members of a cross-functional team to plan, lead and execute the tasks required to support the assigned programs.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Provide statistical expertise and collaborate with various functions on study design/planning, protocol development, statistical methodology/analysis Responsible for the development of statistical analysis plan (SAP), TFL shells and other analysis specifications on assigned studies Responsible for the development of randomization schema on assigned randomized studies Perform data analysis and/or collaborate with statistical programming (inhouse or vendor) to ensure quality analysis conducted per the SAP and specifications Responsible for the development of statistical reports summarizing the data analysis results Ensure adequate interpretation of data/analysis results and consistency/accuracy of data presentation for study reports and publications Collaborate with various functions to ensure robust CRF/EDC development, and quality data collection for the assigned clinical trials Provide quality review of outsourced statistical deliverables (including inhouse double programming to QC as needed) and coordinate the inhouse review comments Stay abreast of industry development in biostatistics/statistical programming fields and apply to appropriate systems and processes Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; &nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; Advanced degree (M.A./M.S. or PhD) preferred, or equivalent experience Experience:&nbsp; A./M.S. with 8+ years, or PhD with 5+ years in biotech/pharmaceutical industry Experience in ophthalmology and/or biologic/gene therapy a plus Experience with all clinical phases (I, II, III, and IV) is desirable Other Qualifications/Skills: Good understanding of standards specific to clinical trials such as CDISC, SDTM, and ADaM, MedDRA, WHODRUG Knowledge of applicable GCP/FDACHMP//ICH/HIPPA regulations Displays excellent organization and time management skills, excellent attention to detail, and ability to multi-task in a fast-paced environment with shifting priorities and/or conflicting deadlines Excellent written and verbal communication skills and strong team player with demonstrated track record of success in cross-functional team environment Travel: &lt;5% Base salary compensation range: $194,000/yr - $234,000/yr &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Director, Biostatistics

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Vice President, Supply Chain is responsible for the end-to-end strategy, execution, and governance of global supply operations across all phases of development. This role ensures uninterrupted, compliant, and cost-effective supply of investigational and commercial products, comparators, ancillaries, and open-label therapies to support global clinical trials and commercial launch. This leader will build and scale a best-in-class supply organization, partner closely with Clinical Operations, CMC, Regulatory, Quality, and external vendors, and provide senior level oversight of supply risk, forecasting, and readiness in support of critical development and registration milestones. MAJOR DUTIES &amp; RESPONSIBILITIES: Strategic Leadership Define and execute the global supply strategy across early- and late-stage programs, including Phase 1–3, commercial launch, and post-approval commitments Serve as the enterprise leader for clinical trial supply governance, risk management, and scenario planning Provide senior-level input into development timelines, enrollment strategies, and global expansion plans based on supply feasibility Anticipate and proactively mitigate supply risks (manufacturing capacity, comparator shortages, import/export constraints, depot limitations, based on deep experience with global supply chain) Drive BLA-enabling supply chain activities, including shipping validation, planning for commercial labeling processes, and temperature monitoring strategies. Provide support for combination device strategy (such as co-packaging with needles and syringes, pre-filled syringes, and other approaches, including device compatibility strategies), and launch forecasting and planning. &nbsp;Operational Oversight Oversee end-to-end clinical supply execution, including: Demand forecasting and supply planning Packaging, labeling, and distribution Depot strategy and inventory management Open-label and rescue medication sourcing (e.g., comparator biologics) Management of drug product inventory, including production needs, regulatory timing, and QP approval for introduction of new lots Balance supply needs with financial ones, including management of cost, expiration dating, potential delays, and clinical enrollment projections. Ensure timely and compliant supply to global investigational sites while supporting enrollment acceleration and protocol amendments Lead contingency planning for constrained supply scenarios and high-enrolling sites &nbsp;Vendor &amp; Partner Management Select, manage, and govern global supply vendors (CMOs, depots, couriers, comparator sourcing partners), and work closely with global CROs (pack and label vendors, clinical trial vendors) to ensure smooth uptake in new countries Establish performance metrics, KPIs, and escalation pathways to ensure vendor accountability Negotiate contracts and manage budgets for clinical supply operations Drive continuous improvement and cost optimization across the supply network &nbsp;Cross-Functional Leadership Partner closely with: Clinical Operations (site activation, enrollment strategy) CMC / Technical Operations (manufacturing timelines, release) Quality Assurance (GxP compliance, audits, inspections) Regulatory Affairs (import/export, labeling, country requirements) Commercial team (BLA and launch planning, commercial supply) Act as a strategic advisor to program teams and executive leadership on supply-related decision-making &nbsp;Quality, Compliance &amp; Inspection Readiness Ensure full compliance with GMP, GDP, ICH, FDA, EMA, and global regulatory requirements Maintain inspection-ready systems, documentation, and processes Lead responses to regulatory inspections, audits, and findings related to supply chain &nbsp;Team Building &amp; Leadership Build, mentor, and lead a high-performing global supply chain organization Establish scalable processes, SOPs, and operating models appropriate for company growth, including selection and introduction of appropriate software tools Foster a culture of accountability, transparency, and proactive problem-solving Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; Bachelor’s degree in Life Sciences, Pharmacy, Engineering, or related field (advanced degree preferred) Experience:&nbsp; 18+ years of experience in clinical trial supply, CMC operations, or pharmaceutical supply chain 7+ years of senior leadership experience managing global teams and vendors Demonstrated experience managing supply for global Phase 3 clinical trials Prior experience leading supply strategy through regulatory submission and launch Deep knowledge of clinical supply planning, comparator sourcing, and global distribution Proven ability to operate effectively in high-complexity, fast-paced biotech environments Preferred: Experience supporting biologic, gene therapy, or specialty ophthalmology products Strong background in managing constrained or high-risk supply scenarios MBA or advanced scientific degree a plus Other Qualifications/Skills:&nbsp; Executive presence and strategic thinking Strong cross-functional influence without direct authority Exceptional problem-solving and risk-mitigation skills Data-driven decision making and forecasting expertise Ability to balance speed, quality, and compliance Clear, confident communicator with internal and external stakeholders Travel: less than 5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $308,000 - $354,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Vice President, Supply Chain

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The incumbent provides strategic statistical input to and oversees all statistical aspects of assigned programs; drives cross-functional collaboration and decision making for program(s); oversees the performance of Contract Research Organizations (CROs); develop and mentor other statisticians, act as Head of Biostatistics when needed. MAJOR DUTIES &amp; RESPONSIBILITIES: Ensures expert level contribution to strategy (design, analysis/synthesis, interpretation and reporting, health authority response, influence and implement publication strategy, quantitative decision making) in the global development program Leads collaborations with clinical, regulatory and other strategic functions to drive quantitative decision making and enables successful impact on robust drug development plans Provides oversight and guidance to staff members within 4DMT and in CROs in completing high quality study deliverables according to agreed timelines following quality standards. Leads and/or participates in the development and review of Policies, SOPs and other controlled documents for process improvement and operational efficiency. Provide statistical and strategical input in regulatory documents and scientific articles. Lead data generation team for podium presentations and payor discussions. Plays a critical role in shaping team development and contributing to departmental strategy. Stays abreast of and contributes to scientific advances in the field. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; PhD in Statistics, biostatistics or related fields or Masters with significant experience Experience:&nbsp; 12+ years of pharmaceutical industry experience with a PhD, or 14+ years with an MS. Hands-on experience working with CDISC standards and programming based on raw datasets, SDTM, and ADaM datasets. 8+ years of management experience Other Qualifications/Skills:&nbsp; Hands-on familiarity with common and advanced statistical methodology. Strong knowledge of SAS programming concepts and techniques in the pharmaceutical; proficiency in tools such as SAS, EAST, and nQuery. Knowledge/experience of global regulatory requirements in novel endpoints and rare diseases is a plus Travel: &lt;5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). àSubstitute physical requirements for Lab Positions with following: Lifting up to 20 lbs, bending, lifting, twisting, ability to wear Personal Protective Equipment such as lab coat, goggles/glasses, and nitrile gloves&nbsp; Base salary compensation range: $301,000/yr - $368,000/yr4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Executive Director, Biostatistics

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The AD, Data Management will be responsible for performing or overseeing vendors to perform Data Management operational end-to-end activities and participate as an active member in a cross-function study team to plan, lead, and execute tasks required for assigned clinical studies across all phases. The AD, Data Management has a broad, fundamental knowledge of the data management process and can perform most required tasks with minimal guidance. Data management is one of the essential functions of the Clinical Development organization at 4DMT. Together with the other two functions within the Data Science group, Biostatistics, and Statistical Programming, we provide critical support for the company’s clinical development programs in gene therapies for retina diseases and other therapeutic areas. MAJOR DUTIES &amp; RESPONSIBILITIES: Lead Data Management of a clinical study or a series of related studies with minimal guidance Manage and monitor the progress of data management activities with CROs, vendors, and stats/programming groups on assigned studies Review protocols for appropriate data capture, including electronic Case Report Form (eCRF) design. Perform a thoroughly detailed review of eCRF data requirements. Lead the development of data edit check specifications and data listings Coordinate Electronic Data Capture (EDC) system design and testing according to company standards. Develop or lead the development of the Data Management and Data Transfer Plan for assigned clinical studies. Attend study meetings and provide Data Management updates and metrics. Review and provide feedback to the clinical team on other study documents, e.g. Clinical Monitoring plans, Statistical Analysis Plans, and vendor specifications Provide training on the EDC system and/or eCRF Completion Guidelines to internal and external study team members as needed Perform or ensure assigned CRO reconciliation of header data from external data sources against the clinical database Perform or ensure assigned CRO completed Serious Adverse Event reconciliation activities according to SOPs and guidelines Lead database upgrades/migrations, including performing User Acceptance Testing Maintain data management files / eTMF Perform and coordinate database interim snapshot, lock, and freeze activities Other duties as assigned: nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time &nbsp; QUALIFICATIONS: Education: B.A./B.S. degree or higher (life-science-related fields preferred); or equivalent experience. Experience: 9+ years of data management experience in the biotech/pharmaceutical industry or clinical data management service providers of which at least three (3+) years in a lead study data manager role. Experience in retina diseases and/or gene therapies a plus. Hands-on operational experience as Data Management Lead in all phases of clinical trials, including development/deployment/validation/maintenance/closeout of a clinical database, coordination of data transfers/reconciliations, training on data management systems, etc. Experience in vendor management and performance assessments In-depth knowledge and experience with CDISC data standards and models. Other Qualifications/Skills: Proficient in using clinical data management systems (e.g., Medidata Rave) and the data flow, including those from external sources (IRT, safety, central/specialty labs, reading centers, PROs, etc.) Proficiency in data management process and knowledge of Good Clinical Data Management Practices (GCDMP) in global clinical trials Knowledge of ICH GCP and other applicable regulatory rules and guidelines. Knowledge of the clinical development process. Proficient with MS Office (Worl, Excel, PowerPoint, etc.) Excellent interpersonal communication skills (written and verbal) Innate collaborative attitude, with demonstrated ability to work effectively in a small company environment that moves at a tremendous pace. Excellent organization and project/time management skills Ability to multitask in a high-volume environment with shifting priority and conflicting deadlines Proven conceptual, analytical and strategic thinking Excellent attention to details Travel: 5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $170,000/yr - $223,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Director, Data Management

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; The Sr. Manager, Clinical Oversight Monitoring (COM Sr. Mgr.) supports the Associate Director, Monitoring Oversight Management, in executing the clinical oversight program across 4DMT studies. This role is responsible for ensuring that clinical monitoring activities performed by CROs and contract monitors align with Clinical Monitoring Plans, study protocols, and ICH/GCP requirements. The Sr. Mgr. will drive consistency in monitoring oversight practices, manage day-to-day execution of oversight tools and processes, and contribute to maintaining inspection readiness and monitoring quality across global programs. MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Execute oversight activities in alignment with the Clinical Oversight Monitoring Plan and related SOPs. Partner with the Associate Director to refine and implement oversight tools, trackers, and metrics dashboards. Conduct quality control (QC) review of monitoring visit reports and follow-up letters to assess completeness, accuracy, and compliance with monitoring expectations. Track visit scheduling, report completion metrics, protocol deviations, and issue resolution to identify trends and risks across CRO, monitor, and site levels. Support the development and maintenance of monitoring oversight dashboards and performance metrics (e.g., timeliness, completeness, issue closure, out-of-window visits). Assist in implementation of risk-based oversight elements such as key risk indicators (KRIs), key performance indicators (KPIs), and quality tolerance limits (QTLs). Collaborate cross-functionally with Clinical Operations, Quality Assurance, and Data Management to ensure consistency in monitoring-related communications, escalation pathways, and issue management. Support vendor oversight by reviewing CRO performance reports, contributing to issue escalation, and tracking CAPA progress. Participate in inspection readiness activities, document reviews, and process audits to ensure oversight documentation is accurate and current. Assist in process improvement initiatives by analyzing oversight data and identifying areas for refinement or standardization. Maintain oversight documentation, trackers, and archives to ensure audit and inspection preparedness. Support onboarding and training of new COM team members and vendor associates on oversight tools and processes. Travel as required (estimated up to 20%). Other duties as assigned. Management reserves the right to adjust responsibilities as business needs evolve. QUALIFICATIONS:&nbsp; Education:&nbsp; A./B.S. degree in related Life Sciences discipline required Equivalent combination of education and applicable job experience may be considered. Experience:&nbsp; A./B.S. with 7+ years of experience in clinical monitoring or oversight roles. Hands-on experience in clinical monitoring, including review of monitoring visit reports and vendor deliverables. Strong understanding of ICH-GCP, FDA, EMA, and other global regulatory requirements. Experience supporting risk-based monitoring (RBM) and quality metrics programs. Demonstrated ability to review, interpret, and analyze monitoring data and reports. Familiarity with vendor oversight processes, including KPI tracking and issue management. Experience supporting audit or inspection readiness activities. Proficiency with oversight tools and systems (CTMS, eTMF, dashboards, Microsoft Office Suite). Experience in ophthalmology or retina therapeutic areas preferred. Other Qualifications/Skills: The ideal candidate will embody 4DMTs core values: Dare to Cure - Break Boundaries - Beyond Yourself - Prepare &amp; Executive Relentlessly Strong interpersonal communication (written and verbal), and organizational skills Able to motivate a team to work effectively in a fast-paced and changing environment Strong work ethic and demonstrated ability to deliver assignments on time Proficient with office automation tools, such as Microsoft Office toolkit. Excellent Microsoft Excel skills specifically. Strong professional experience in a similar role within the pharmaceutical industry. Well organized with the ability to multitask, prioritize, and manage shifting responsibilities in a dynamic, cross-functional teamwork environment. Excellent collaboration skills with strong attention to detail and the ability to multi-task and manage complexity. Ability to adapt to modification and changes to project plans, demonstrating flexibility to implement new strategies and tactics to accommodate these changes. Travel: Up to 20% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $134,000/yr - $178,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Sr. Manager, Clinical Oversight Monitoring

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Associate Director, Statistical Programming provides technical leadership and operational oversight for statistical programming activities across multiple clinical development programs. This role is accountable for the accuracy, quality, and timeliness of programming deliverables for clinical trial reporting, integrated safety/efficacy analyses, and global regulatory submissions. The position also drives the development and maintenance of programming standards, SOPs, and tools, and ensures compliance with CDISC standards, ICH GCP, and applicable regulatory requirements. The incumbent will collaborate closely with cross functional teams and external vendors and may manage and mentor programming staff. &nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Programming Leadership &amp; Delivery Lead statistical programming activities for assigned programs, including oversight of CRO deliverables. Develop, review, and execute SAS programs to produce SDTM/ADaM datasets, tables, figures, and listings in accordance with SAPs. Perform quality control (QC) of programming deliverables to ensure accuracy, consistency, and compliance. Support ad hoc, exploratory, and postdoc analyses as needed. Regulatory &amp; Submission Readiness Prepare and standardize data packages for regulatory submissions (BLA, NDA, MAA), including ISS/ISE deliverables. Ensure CDISC compliance using implementation guides and validation tools (e.g., Pinnacle 21). Review and approve dataset specifications, output shells, and reviewer’s guides (SDRG, ADRG). Process &amp; Standards Development Develop and maintain programming SOPs, guidelines, macros, and reusable tools. Contribute to process improvement and standardization initiatives within the Biometrics function. Stay current with evolving regulatory requirements, industry standards, and emerging technologies. Cross Functional Collaboration Represent Statistical Programming in internal and external meetings. Partner with Biostatistics, Data Management, Regulatory, and Clinical teams to align deliverables and resolve issues. Communicate technical concepts clearly to both technical and non‑technical stakeholders. Team &amp; Vendor Management Manage internal programming resources and mentor junior staff. Participate in CRO selection, contracting, and performance evaluation. Ensure vendor deliverables meet agreed timelines, quality standards, and contractual obligations. QUALIFICATIONS:&nbsp; Education:&nbsp; BS in Statistics, Biostatistics, Mathematics, Computer Science, or related field with significant experience required. Master’s or PhD preferred. Experience:&nbsp; 9+ years of statistical programming experience in pharmaceutical, biotechnology industry w/ Bachelors. 7+ years w/ Masters. 4+ years w/ PhD Expert proficiency in SAS (Base, Macro, Stat, Graph, ODS); working knowledge of R or Python preferred. Deep knowledge of CDISC SDTM/ADaM standards, metadata, and regulatory submission requirements. Experience with Pinnacle 21 and preparation of reviewer’s guides. Strong understanding of clinical trial design, data collection, and reporting processes. Experience in Gene Therapy Experience in ophthalmology preferred Other Qualifications/Skills:&nbsp; Excellent communication, problem‑solving, and project management skills. Ability to manage multiple priorities in a fast‑paced, matrixed environment. Travel: 10% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $185,000/yr - $227,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Director, Statistical Programming

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: 4DMT is seeking an experienced intellectual property attorney, with a focus in patent prosecution, to manage 4DMT’s intellectual property portfolio and provide strategic counsel and training on all facets of patent, trade secret, trademark, and copyright law, including procurement, registration, enforcement, freedom to operate, and IP litigation. The role will also counsel 4DMT’s R&amp;D and CMC teams on a wide range of day-to-day transactions with partners that are central to their work, and well as provide IP input on strategic transactions and support IP diligence efforts. The role will work cross-functionally with R&amp;D, CMC, Finance, Business Development, and IT teams, and may interact with other teams, depending on project needs. The role will report to and be a strategic thought partner to the Chief Legal Officer. The ideal candidate must be an experienced attorney, with a strong background in the biopharmaceutical industry and excellent business judgment and interpersonal skills. In depth knowledge of the drug development process, regulatory and compliance requirements, strategic partnerships, and commercial strategy is strongly preferred.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: Collaborate with Chief Legal Officer on development of 4DMT’s intellectual property strategy. Responsible for implementing key elements of 4DMT’s intellectual property strategy, and manages its patent, trade secret, and trademark portfolio; implements a strategy for IP lifecycle management. Directs outside counsel in the preparation and prosecution of applications and responding to office actions; directs outside counsel in evaluating the patentability of invention submissions and registrability of trademarks globally; manages related outside counsel budgets. Identifies strategic areas for patenting, trade secret protection, and trademarking; collaborates with R&amp;D, CMC, Clinical Science, and other functions to proactively identify and develop patentable intellectual property to prepare, file, and prosecute. Manages patentability, freedom-to-operate, infringement, validity, and regulatory exclusivity analyses. Identifies and tracks 4DMT trade secrets and provides counsel with respect to 4DMT’s trade secret protection practices. Provides IP perspective and counseling at 4DMT meetings and presents on IP topics. Counsels and trains internal clients on intellectual property practices and policies. Conducts IP due diligence for business development activities and supports IP due diligence related to financing activities. Drafts, reviews, and negotiates agreements to support R&amp;D and CMC activities, including NDAs, MTAs, MSAs, sponsored research agreements, consulting agreements, and licenses. Collaborates with Legal colleagues, Business Development, and other key leaders and functions on key strategic agreements, including licenses, collaboration agreements, and other business development efforts. Assists with other Legal Department matters, including litigation support, SEC reporting (IP-related sections), records management, compliance activities, and template projects. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. QUALIFICATIONS:&nbsp; Education: J.D. degree or equivalent from an accredited law school Ph.D. in molecular biology, genetics, biochemistry, or other biological field related to the biopharma industry Admission to at least one U.S. state bar Registered to practice before the United States Patent and Trademark Office Experience: Required: 10+ years of patent prosecution experience as an attorney in the life sciences field, particularly in biopharma (can be a combination of law firm and in-house experience). Strong knowledge of patent, trade secret, and trademark practices, as well as current U.S. and foreign patent, trade secret, and trademark laws In-house experience in and knowledge of drug development, with expertise in genetic medicines strongly preferred; in-house experience at one or more publicly traded, commercial-stage biotechnology, pharmaceutical, or biopharmaceutical companies. Experience managing outside IP counsel and non-attorney legal staff Strongly preferred: Experience in counseling life sciences R&amp;D and CMC teams with respect to day-to-day transactions, including experience reviewing and negotiating confidentiality agreements, manufacturing agreements, material transfer agreements, sponsored research agreements, master services agreements, consulting agreements, and licenses. Prior experience providing IP input on life sciences strategic transactions. Prior IP litigation experience. Other competencies: Excellent analytical and organizational skills and demonstrated ability to effectively collaborate and manage several simultaneous projects under deadline pressure. Excellent communication (verbal and written), listening, negotiation, and presentation skills. Solid interpersonal skills and the demonstrated ability to influence and partner across all levels of the Company. Highest integrity, excellent judgment, and the ability to proactively recognize and effectively communicate legal issues to the Chief Legal Officer and other members of company management. Travel: 5% Physical Requirements and Working Conditions: Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $280,000 - $330,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.&nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities&nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Director, Intellectual Property

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Medical Director, Ophthalmology will contribute to the design, start-up, execution, analysis, and communication of the clinical studies in Ophthalmology. This highly visible role will collaborate with clinical operations, biometrics, data management, regulatory affairs, CMC, pharmtox, drug safety, key sites/PI communications, commercial, and alliance partners (CRO/CRC and other vendors). *Specialization is retinal disease/imaging/gene therapy is required as well as strong Phase III clinical research experience." MAJOR DUTIES &amp; RESPONSIBILITIES: Act as medical monitor in clinical ophthalmology studies with a focus on safety, data review and analysis of emerging data Contribute to study related documents including but not limited to study synopsis, protocols, amendments, ICFs, IBs, INDs, annual reports, CSRs, and other regulatory submissions and project-related documents. Accountable for the medical content of documents. Analyze, interpret, and organize data for presentations and publications Interact with external experts to gather input. Organize scientific advisory board meetings and data safety monitoring committee meetings Maintain a high level of clinical and scientific expertise in ophthalmologic disease area(s) by reviewing the literature and attending medical/scientific meetings Ability to communicate with Investigators and research site staff to ensure rigorous and compliant study conduct Able and willing to travel Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS:&nbsp; Education: Medical Degree (M.D.) with clinical experience Clinical residency training in ophthalmology required. Experience: Experience with retinal disease, retinal imaging, or gene therapy 5+ years of experience in clinical research in the pharmaceutical/biotech industry. Experience writing clinical research protocols and acting as a medical monitor preferred. Experience in multiple phases of clinical research (Phase 1-3) required 4 yrs Phase III clinical research experience required Other Qualifications/Skills: Effective written and verbal communication skills Knowledge of ICH-GCP and FDA regulatory guidelines. Knowledge of international regulatory requirements a plus Able to work in a fast-paced, team-based environment; able to multitask and be a self-starter Travel: 10% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $275,000/yr - $340,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Medical Director

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: Reporting to the VP Clinical Science, the Senior Director, Clinical Science will play an integral role in facilitating successful advancement of ophthalmology gene therapy programs. The position supports clinical and scientific aspects of all assigned clinical programs. MAJOR DUTIES &amp; RESPONSIBILITIES: Partner with cross-functional program team members and key R&amp;D stakeholders to support the development of innovative study designs, clinical trial protocols and amendments, investigator brochures, and other documents required to conduct clinical trials Provide clinical support for clinical study conduct, including operational feasibility, data management, communication plans, safety and medical monitoring, preparation of meeting materials and study updates. Provide scientific support and cleaning/querying of key safety and efficacy data for ongoing clinical trials throughout conduct Prepare and communicate clear overviews of trial results. Identify issues related to study conduct and/or subject safety. Provide preliminary assessments and recommendations and collaborate with the clinical team to develop solutions ensure resolution. Interact with internal and external stakeholders (study sites, vendors, KOLs, etc.) in support of program-level strategy as well as clinical trial objectives Act as recognized clinical expert for assigned programs. Contribute to the preparation of medical and scientific data for publications, presentations, and study milestones (including meetings for Executive Team, Board of Directors, Advisory Boards and Data and Safety Monitoring Committees [DSMC]) Together with Medical Director of Ophthalmology, serve as a point of contact for the clinical operations personnel, clinical trial sites and CROs for clinical science questions Maintains knowledge of ICH-GCP and FDA IND, and external regulations and procedures. Contribute to authoring clinical documents such as protocol synopsis, clinical study reports, IBs, ICFs, training documents, and other clinical documents. Author pertinent clinical sections of regulatory filings, including preparation of routine correspondence and sections of INDs, BLAs, NDAs, Annual Reports, Amendments, Supplements, Orphan Drug Applications, and other regulatory submissions Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS: Education: A./M.S. in a biological/health science field is required OD, PhD, or PharmD preferred Experience: A./M.S. with 12+ years Clinical science experience, or OD, PhD or PharmD with 8+ years of exeirence with 5+ years of drug development with experience in ophthalmology drug development, preferably in retinal disease Advanced experience in clinical trial design, implementation, regulatory document preparation and statistics. Phase 3 experience, retinal gene therapy experience, NDA/BLA/MAA submission experience Other Qualifications/ Skills: Ability to interpret, analyze, and present clinical data Thorough understanding of the drug development process Broad understanding of functional areas of drug development, including preclinical, regulatory, pharmacovigilance, drug supply, data sciences (data management, biostatistics, programming), and clinical operations (including site selection, study start-up, study conduct, and finalization). Demonstrated ability to communicate and write clearly, concisely, and effectively. Ability to understand, interpret and communicate clinical information including literature reviews, competitive intelligence, and changing treatment paradigms in order to apply knowledge to support a robust clinical development strategy. Understanding of trial design and statistics Well-organized: ability to prioritize tasks with a successful track record of managing multiple projects in a fast-paced and deadline-driven environment. Good leadership and management skills to manage internal and external collaborations and work well within cross-disciplinary teams. Travel: 10% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). &nbsp; Base salary compensation range: $268,000/yr - $341,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Director, Clinical Science

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; Reporting to the VP, clinical development or the CMO, the Executive Medical Director is accountable for the design, execution, and analysis of clinical trials in the Ophthalmology Therapeutic Area.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES:&nbsp; Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.&nbsp; Serves as medical monitor on clinical studies. Serves as the primary clinical author of development plans, study protocols, amendments, ICFs,&nbsp;IBs, INDs, annual reports, CSRs, regulatory submissions / correspondence, and project-related documents. Accountable for the accuracy of all medical content of such documents. Works with the research organization and the portfolio management team to identify and support new project opportunities. Collaborates to identify program risks, and to create and implement mitigation strategies Other duties as assigned QUALIFICATIONS:&nbsp; Education:&nbsp; Medical Degree (M.D.) Residency training in Ophthalmology with a preference for subspecialty training in retina Board certification/retina fellowship training are a plus Experience:&nbsp; 9+ years of clinical ophthalmology research in the biopharmaceutical industry Experience with medical monitoring and oversight of Phase 3 retina clinical trials Experience with gene therapy clinical studies Experience in other phases (Phase 1, 2, 4) of clinical research. Experience with NDA/BLA/MAA submission planning and execution Experience in data analysis, data interpretation, and medical writing Other Qualifications/Skills:&nbsp; Knowledge of ICH-GCP and FDA regulatory guidelines. Knowledge of international regulatory guidelines Effective written and verbal communication skills, including public speaking Travel: up to 20% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $352,000 - $422,000/yr Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Executive Medical Director

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The Sr Manager, Statistical Programming provides technical leadership for statistical programming activities for a given clinical development program. This role is accountable for the accuracy, quality, and timeliness of programming deliverables for clinical trial reporting, integrated safety/efficacy analyses, and global regulatory submissions. The position also drives the development and maintenance of programming standards and tools, and ensures compliance with CDISC standards, ICH GCP, and applicable regulatory requirements. The incumbent will collaborate closely with cross‑functional teams and external vendors. MAJOR DUTIES &amp; RESPONSIBILITIES: Programming Leadership &amp; Delivery Lead statistical programming activities for assigned programs, including oversight of CRO deliverables. Develop, review, and execute SAS programs to produce SDTM/ADaM datasets, tables, figures, and listings in accordance with SAPs. Perform quality control (QC) of programming deliverables to ensure accuracy, consistency, and compliance. Support ad hoc, exploratory, and post‑hoc analyses as needed. Regulatory &amp; Submission Readiness Prepare and standardize data packages for regulatory submissions (BLA, NDA, MAA), including ISS/ISE deliverables. Ensure CDISC compliance using implementation guides and validation tools (e.g., Pinnacle 21). Review and approve dataset specifications, output shells, and reviewer’s guides (SDRG, ADRG). Process &amp; Standards Development Contribute to process improvement and standardization initiatives within the Biometrics function. Stay current with evolving regulatory requirements, industry standards, and emerging technologies. Cross‑Functional Collaboration Represent Statistical Programming in internal and external meetings. Partner with Biostatistics, Data Management, Regulatory, and Clinical teams to align deliverables and resolve issues. Communicate technical concepts clearly to both technical and non‑technical stakeholders. Team &amp; Vendor Management Participate in CRO selection, contracting, and performance evaluation. Ensure vendor deliverables meet agreed timelines, quality standards, and contractual obligations. QUALIFICATIONS:&nbsp; Education:&nbsp; Master’s or PhD in Statistics, Biostatistics, Mathematics, Computer Science, or related field (BS with significant experience considered). Experience:&nbsp; 7+ years of statistical programming experience in pharmaceutical, biotechnology industry w/ Bachelors. 4+ years w/ Masters. 3+ years w/ PhD Expert proficiency in SAS (Base, Macro, Stat, Graph, ODS); working knowledge of R or Python preferred. Deep knowledge of CDISC SDTM/ADaM standards, metadata, and regulatory submission requirements. Experience with Pinnacle 21 and preparation of reviewer’s guides. Strong understanding of clinical trial design, data collection, and reporting processes. Experience in Gene Therapy Experience in ophthalmology preferred Other Qualifications/Skills:&nbsp; Excellent communication, problem‑solving, and project management skills. Ability to manage multiple priorities in a fast‑paced, matrixed environment. Travel: 10% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $154,000 - $179,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Manager, Statistical Programming

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY&nbsp; We are seeking a highly skilled and experienced Senior Infrastructure and Security Engineer to join our dynamic and growing team. This role is pivotal in ensuring the seamless operation, scalability, and security of 4DMT’s IT infrastructure, enterprise end-user services, and cloud environments. The Senior Infrastructure and Security Engineer will play a key role in designing, implementing, and maintaining cutting-edge infrastructure and security solutions to support organizational growth and innovation. &nbsp; This role oversees 4DMT’s&nbsp; IT endpoint infrastructure and enterprise end-user services&nbsp; IT infrastructure, including servers, cloud services, hardware systems, and applications&nbsp; Planning and implementation of comprehensive infrastructure solutions aligned with organizational needs.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES:&nbsp; Infrastructure Design &amp; Management:&nbsp; Plan, design, develop, and implement scalable, secure, and user-focused&nbsp;hybrid&nbsp;IT solutions, including&nbsp;world-class infrastructure, Cloud,&nbsp;high-end workstations, desktops, laptops, mobile devices (secure BYOD).&nbsp; Manage virtualization technologies (e.g., VDI/VM) to enable flexible work arrangements.&nbsp; Deploy and configure Windows, macOS, and Linux operating systems to ensure compatibility, performance, and compliance with security standards.&nbsp; Administer and support Active Directory environments, including Group Policy management, user accounts, and domain controller maintenance.&nbsp; Maintain and&nbsp;optimize&nbsp;Windows Server and Linux systems, ensuring high availability, security, and performance.&nbsp; Support Google Cloud Platform (GCP) infrastructure, including&nbsp;compute, storage, and networking services, while leveraging GCP tools for monitoring, security, and cost optimization.&nbsp; Implement and&nbsp;maintain&nbsp;system images, software packages, and productivity/business applications.&nbsp; Automation &amp; Optimization:&nbsp; Develop and manage automation scripts and workflows to&nbsp;optimize&nbsp;operations, enhance user experience, and increase efficiency.&nbsp; Build comprehensive automated infrastructure management solutions, including configuration management, monitoring, and analytics, to improve operational efficiency and reliability.&nbsp; Continuously&nbsp;identify&nbsp;opportunities for automation and process improvement, driving innovation and operational excellence.&nbsp; System Monitoring &amp; Troubleshooting:&nbsp; Proactively&nbsp;monitor&nbsp;system performance and ensure high availability, reliability, and scalability.&nbsp; Rapidly troubleshoot and resolve hardware, software, and system issues, including those related to Active Directory, Windows, Linux, and GCP environments.&nbsp; Security &amp; Compliance:&nbsp; Security Operations: &nbsp; Implement and maintain cybersecurity controls for infrastructure and endpoints, including vulnerability management and data loss prevention. &nbsp; Support the detection and response to security incidents, assisting with forensic investigations and remediation. &nbsp; Policy &amp; Compliance: &nbsp; Help develop and update security policies, standards, and procedures for IT infrastructure and end-user services. &nbsp; Participate in risk assessments and contribute to strategies that address information security, business continuity, and compliance requirements. &nbsp; Ensure compliance with regulatory requirements (e.g., SOX, 21 CFR Part 11) and industry best practices. &nbsp; Awareness &amp; Reporting: &nbsp; Assist with security awareness initiatives to educate staff on policies and best practices for protecting company assets. &nbsp; Monitor infrastructure security metrics and report on performance to ensure continuous improvement. &nbsp; Demonstrate extensive expertise in Google Cloud Platform (GCP), including advanced security, monitoring, automation, and optimization of cloud infrastructure. &nbsp; Collaboration &amp; Support:&nbsp; Provide technical support to end users, resolving issues promptly and effectively. &nbsp; Collaborate with cross-functional IT and security teams, as well as external partners, to assess needs, address emerging threats and vulnerabilities, and integrate technology solutions. &nbsp; Foster strong relationships with stakeholders to align technology solutions with business goals. &nbsp; Technology Evaluation:&nbsp; Evaluate emerging technologies and recommend solutions that align with business&nbsp;objectives&nbsp;and budget constraints.&nbsp; Stay current with industry trends to inform organizational decisions and future-proof solutions.&nbsp; Other Responsibilities:&nbsp; Participate in audits as needed and ensure alignment with IT policies and standards.&nbsp; Perform other duties as assigned, adapting to the dynamic needs of the organization.&nbsp; &nbsp;QUALIFICATIONS: &nbsp; Education: &nbsp; Industry recognized technical level education &amp; experience.&nbsp; CISSP&nbsp;or GCP Certification preferred.&nbsp; Experience: &nbsp; 3-5&nbsp;years' experience as user-focus infrastructure engineer delivering solutions in highly regulated,&nbsp;complex&nbsp;and multi-vendor ecosystems with a strong preference for candidates having pharma or biotech industry&nbsp;expertise&nbsp;and a deep understanding of compliance-driven environments.&nbsp; 3-5&nbsp;years' experience managing desktop and server OS and application patching and application packaging using sophisticated management systems (e.g.&nbsp;Intune, System Center Configuration Manager)&nbsp; 3-5&nbsp;years' experience supporting Windows Enterprise customers in a large-scale (300+ node) environment.&nbsp;&nbsp;&nbsp;&nbsp; Other Experience:&nbsp; Successful&nbsp;track record&nbsp;of infrastructure architecture and administration, execution, and delivery.&nbsp;&nbsp; Ability to multi-task in a fast-paced, dynamic environment.&nbsp; Experience working in a regulated networking environment (SOX and 21CFR11).&nbsp; Excellent organizational,&nbsp;communication&nbsp;and customer service skills with active-listening skills.&nbsp; Proven adaptability to shifting project schedules, priorities, and assignments; able to make effective decisions under pressure.&nbsp;&nbsp; Demonstrated problem-solver with the ability to cope under pressure and coordinate multiple activities in a dynamic, fast-paced team environment.&nbsp;&nbsp; Excellent written and documentation skills including proof reading and attention to detail.&nbsp; Hands-on experience with hardware and software troubleshooting, system imaging, and software deployment tools.&nbsp; Must be a self-driven, motivated IT professional with strong analytical and problem-solving skills, and ability to diagnose and resolve complex technical issues.&nbsp; Excellent communication and interpersonal skills, with the ability to work effectively in a team environment and interact with diverse stakeholders including executive management.&nbsp; Proactively&nbsp;identify&nbsp;opportunities for process improvements and automation to streamline end-user support services.&nbsp; Proficient in automation technologies, including Pipeline Pilot, MS Power Automate and&nbsp;additional&nbsp;scripting languages, with a strong ability to&nbsp;leverage&nbsp;scripting&nbsp;expertise&nbsp;to streamline processes, enhance efficiency, and drive operational excellence.&nbsp; Demonstrate extensive&nbsp;expertise&nbsp;in Google Cloud Platform (GCP) and Azure, including advanced security, monitoring, automation, and optimization of cloud infrastructure" under the Security &amp; Compliance section.&nbsp; Comprehensive&nbsp;expertise&nbsp;in operating systems (Windows, macOS, Linux), virtualization technologies (e.g., VMware, Citrix Virtual Apps and Desktops), and endpoint management solutions (e.g., Microsoft Intune, SCCM, Tanium), M365, Okta, Active Directory, etc.&nbsp;&nbsp; &nbsp;Other Qualifications/Skills: &nbsp; Strong hands-on experience with Active Directory, Windows, Linux, Google Cloud Platform (GCP), and Azure.&nbsp; 5+ years biopharmaceutical experience in&nbsp;fast-growing environment.&nbsp; Office environment with daily onsite presence&nbsp;required.&nbsp;&nbsp; Daily onsite presence in an office environment.&nbsp; Proven ability to adapt to shifting priorities while&nbsp;maintaining&nbsp;attention to detail and delivering high-quality results.&nbsp; &nbsp;Travel:&nbsp;N/A&nbsp; &nbsp;Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work).&nbsp; Base salary compensation range:&nbsp;HR ONLY&nbsp; Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Infrastructure and Security Engineer

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The Associate Director, Biostatistics provides strategic input and technical expertise on statistical methodology to lead assigned projects. They will participate as active members of a cross-functional team to plan, lead and execute the tasks required to support the assigned programs. The incumbent will collaborate closely with cross‑functional teams and external vendors. MAJOR DUTIES &amp; RESPONSIBILITIES: Provide statistical expertise and collaborate with various functions on study design/planning, protocol development, statistical methodology/analysis Responsible for the development of statistical analysis plan (SAP), TFL shells and other analysis specifications on assigned studies Responsible for the development of randomization schema on assigned randomized studies Perform data analysis and/or collaborate with statistical programming (inhouse or vendor) to ensure quality analysis conducted per the SAP and specifications Responsible for the development of statistical reports summarizing the data analysis results Ensure adequate interpretation of data/analysis results and consistency/accuracy of data presentation for study reports and publications Collaborate with various functions to ensure robust CRF/EDC development, and quality data collection for the assigned clinical trials Provide quality review of outsourced statistical deliverables (including in-house double programming to QC as needed) and coordinate the in-house review comments Stay abreast of industry development in biostatistics/statistical programming fields and apply to appropriate systems and processes Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; Advanced degree (M.A./M.S. or PhD) preferred, or equivalent experience Experience:&nbsp; A./M.S. with 7+ years, or PhD with 4+ years in biotech/pharmaceutical industry Experience in ophthalmology and/or biologic/gene therapy a plus Experience with all clinical phases (I, II, III, and IV) is desirable Other Qualifications/Skills: Good understanding of standards specific to clinical trials such as CDISC, SDTM, and ADaM, MedDRA, WHODRUG Knowledge of applicable GCP/FDACHMP//ICH/HIPPA regulations Displays excellent organization and time management skills, excellent attention to detail, and ability to multi-task in a fast-paced environment with shifting priorities and/or conflicting deadlines Excellent written and verbal communication skills and strong team player with demonstrated track record of success in cross-functional team environment Travel: &lt;5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $194,000 - 220,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; Reporting to the Chief Medical Officer the VP Late Stage Ophthalmology provides strategic and operational leadership for the global development of ophthalmic genetic medicines in Drug Development. We seek an experienced physician to play a critical role at 4DMT as we spearhead the introduction of the first intravitreally delivered genetic medicines for the treatment of the most common causes of irreversible blindness. The VP, Late Stage Ophthalmology will be the primary point person for medical oversight of clinical studies with responsibilities to include medical monitoring, review and interpretation of clinical trial data, clinical trial design, protocol development, and drafting of key clinical documents such as protocol, CSR, briefing package, IND, NDA, BLA, etc. This role will be responsible for timely execution of deliverables in close collaboration with relevant internal and external partners. RESPONSIBILITIES:&nbsp; Serve as the primary medical monitor for multiple ophthalmology clinical trials, providing expert oversight of patient safety, data integrity, and protocol adherence throughout study execution. Direct and mentor a team of medical monitors, ensuring high standards of medical oversight and data review, while maintaining personal accountability for real-time monitoring activities and timely delivery of critical clinical trial outputs Provide medical leadership for cross-functional internal workstreams including pharmacovigilance, biostatistics, clinical operations, regulatory affairs, etc. Provide oversight and lead teams responsible for development plans, study protocols, amendments, ICFs, IBs, INDs, annual reports, CSRs, regulatory response documents and other regulatory submissions or documents as appropriate Collaborate closely with Clinical Operations and be accountable for clinical trial conduct and timelines for associated key deliverables. Keep up to date with compliance, SOPs and adhere to ICH, GCP, and relevant regulatory guidelines. Provide medical leadership for internal audits and regulatory inspections. Assist in preparation of materials for Advisory Board meetings, BOD meetings, etc Represent 4DMT and Lead interactions and collaborations with potential partners Represent the Ophthalmology Therapeutic Area with key external stakeholders, including patients and patient advocacy groups, external experts, investors, and the ophthalmic and biotech business communities Travel Domestic and Internationally as required ~20% QUALIFICATIONS:&nbsp; Education:&nbsp; M.D. Degree Clinical training in Ophthalmology Retina fellowship training a plus Board Certification (or equivalent) Experience:&nbsp; Minimum of 8 years of biopharma industry experience in drug development Phase 3 experience in retinal disease (s), diabetic eye disease highly preferred Experience with NDA, BLA or MAA submission(s). Drug approval(s) a plus. Experience with gene therapy, other areas of Drug Development and commercialization is a plus Skills:&nbsp; Strong interpersonal skills and high emotional coefficient Highly effective written and verbal communication skills Excellent analytical, problem-solving and strategic planning skills. Up to date understanding of the ophthalmic competitive landscape with a focus on retina Prior Clinical Trial experience in Retina, Diabetic Eye Disease Experience in participating or leading global regulatory interactions Ability to understand and translate complex data to key messages Ability to thrive in a fast-paced environment. Proven ability to prioritize effectively Proven ability to plan and conduct clinical trials ensuring high-quality trial execution and results within established timelines; demonstrated track record in working effectively in cross-functional teams and work streams (pharmacovigilance, biostatistics, clinical operations, and regulatory. Track record of thinking strategically and executing to strategy Demonstrated success in influencing colleagues and senior leaders in various departments. Experience building and leading teams and driving engagement in a matrixed environment.&nbsp; Attention to detail, internal drive to generate high-quality work, and sense of passion and urgency to achieve team and program goals. Able to ensure accountability Able to manage conflict Comfortable managing ambiguity Strong clinical and scientific knowledge of ophthalmology (and retinal disease in particular) Track record of developing talent Record of cultivating and managing internal and external cross-functional collaborations. Demonstrates high integrity. Experience in successfully presenting and interacting with the Ophthalmic Retina Community and regulatory authorities in US, EU and APAC Integrated understanding of FDA, EMA, ICH, and GCP guidelines. Prior interactions with FDA and EMA regulatory agencies is desirable. Base salary compensation range: $350,000 - $440,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Vice President, Late Stage Ophthalmology - DME

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The Clinical Technology, IT is the accountable owner for the strategy, delivery, and operational integrity of information systems supporting 4DMT’s Clinical Research and Development organization. This role ensures clinical systems are fit for purpose, inspection-ready, and maintained in a validated state, while advancing technology solutions that enable efficient, compliant clinical execution. The position serves as the primary liaison between Clinical R&amp;D, Data Management, IT, and external vendors, driving alignment, governance, and disciplined system ownership across the full lifecycle—from design and implementation through operation and retirement. MAJOR DUTIES &amp; RESPONSIBILITIES: Own and operate clinical systems as system owner, including access control, configuration, validation, and lifecycle management. Ensure systems remain compliant with GxP regulations and internal SOPs, preserving data integrity and inspection readiness. Lead requirements definition, solution design, and implementation planning with cross-functional stakeholders. Provide Level-2 application support and vendor coordination for incident resolution and system enhancements. Maintain and continuously improve system documentation, including validation deliverables, SOPs, and operational records. Partner with Clinical Data Management to support data quality, flow, and operational needs. Execute core system governance activities, including performance monitoring, upgrades, disaster recovery testing, access reviews, and license and vendor management. Drive system adoption through training, documentation, and user enablement. Support audits and regulatory inspections, including inspection responses, remediation, and CAPA closure. Contribute to product roadmaps and release planning, balancing business value, regulatory risk, and technical feasibility. Manage and maintain collaborative relationships with core business partners. QUALIFICATIONS: 8–12+ years of experience implementing and operating technology solutions supporting clinical research and development. Proven experience across the CSV lifecycle, including validation, production deployment, support, and decommissioning. Strong working knowledge of FDA and EMA regulations, including 21 CFR Part 11, Parts 210/211, EU Annex 11, CSA principles, and GDPR. Broad technical fluency across applications, infrastructure, cloud platforms, integrations, and operations. Bachelor’s degree in Computer Science, Engineering, Life Sciences, or a related discipline (or equivalent experience). Preferred Experience: Collaboration with Clinical Data Management and Biometrics teams. Experience with Medidata Rave, SAS (Grid, Viya, 9.4), Spotfire, and Veeva TMF and RIM. Experience operating systems in Google Cloud environments. Strong vendor management and service governance experience. Experience with product road mapping, KPIs, and SLAs aligned to clinical priorities. Exposure to low-code platforms and applied AI in clinical research. Base salary compensation range: $103,000 - $140,000 &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Clinical Technology Manager, IT

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; 4DMT needs a motivated, team-oriented, and experienced Administrative Assistant. The primary function of this role is to contribute to the efficiency of the Office of the CEO and will report directly to the Senior Executive Assistant.&nbsp;&nbsp;This is a hybrid position, with in-office days arranged according&nbsp;to&nbsp;the business&nbsp;needs and&nbsp;determined&nbsp;by the hiring manager.&nbsp; MAJOR DUTIES &amp;&nbsp;RESPONSIBILITIES:&nbsp;&nbsp; ADMINISTRATIVE SUPPORT FUNCTIONS:&nbsp;35&nbsp;% of TIME&nbsp; Assistant to&nbsp;Senior&nbsp;Executive Assistant:&nbsp;Support the Senior Executive Assistant&nbsp;(the hiring&nbsp;manager)&nbsp;&nbsp;as&nbsp;they manage multiple priorities and&nbsp;complete&nbsp;ad hoc task requests as business needs require.&nbsp;This includes tasks relating to supporting the Chief of Staff and CFO and Investor Relations workstream, as directed by&nbsp;the hiring manager&nbsp; Calendar Management:&nbsp;As directed by the manager, scheduling and rescheduling meetings and appointments, recurring meetings,&nbsp;and&nbsp;arranging schedules to&nbsp;accommodate&nbsp;ad hoc, high-urgency meetings.&nbsp;&nbsp;Requires&nbsp;prompt&nbsp;real-time response to changing business needs and close collaboration with Senior Executive Assistant.&nbsp; All Hands Meeting Support:&nbsp;Under the direction of the hiring manager, send&nbsp;calendar invites, collect agenda items, prepare draft agenda, and provide support during virtual or face-to-face meetings.&nbsp;&nbsp; Internal Communications Support:&nbsp;Assist&nbsp;the&nbsp;hiring manager&nbsp;with&nbsp;posting and&nbsp;updating&nbsp;4Cast intranet&nbsp;news posts and content under the direction of the&nbsp;hiring manager&nbsp; MEETINGS AND TRAVEL LOGISTICS:&nbsp;25% of TIME&nbsp; Meeting Logistics and Planning:&nbsp;Under the direction of&nbsp;the&nbsp;hiring manager, plan&nbsp;logistics&nbsp;and catering,&nbsp;and lodging&nbsp;for off-site meetings,&nbsp;on-site&nbsp;meetings,&nbsp;and employee events. Follow 4DMT budget and&nbsp;purchasing&nbsp;guidelines&nbsp; Travel Planning:&nbsp;&nbsp;Arrange&nbsp;domestic and international travel, including air and ground transportation, hotel reservations, out-of-town dining, and car rentals.&nbsp;&nbsp;Complete registration for conferences and events.&nbsp;Prepare and update itineraries as arrangements change.&nbsp;&nbsp;&nbsp; EVENT PLANNING:&nbsp;20% of TIME&nbsp; Event Planning:&nbsp;Coordinate&nbsp;logistics&nbsp;for employee&nbsp;engagement&nbsp;and&nbsp;social and&nbsp;volunteer events as directed by&nbsp;the&nbsp;manager&nbsp;and in compliance with HR policies&nbsp;&nbsp; EXPENSES AND PURCHASING SUPPORT:&nbsp;10&nbsp;% of TIME&nbsp; Expense Reporting:&nbsp;Reconcile expense reports&nbsp;monthly&nbsp;using Nexonia. Collect and&nbsp;submit&nbsp;receipts&nbsp;in accordance with&nbsp;4DMT policies&nbsp; Purchasing, Contracts, Invoices:&nbsp;Process contracts,&nbsp;purchasing, and payment processing using Ironclad and Coupa systems&nbsp; ADDITIONAL DUTIES: 5% of TIME&nbsp; Back Up Support: Provide occasional backup Admin support for Sr. EA while on PTO, support other members on the 4DMT Administrative Team during PTO or peak activity&nbsp;as requested and approved by the manager&nbsp; Other&nbsp;Duties as&nbsp;Assigned: Nothing in this job description restricts management’s right to assign or&nbsp;reassign&nbsp;duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; BA&nbsp;or equivalent&nbsp;relevant work&nbsp;experience&nbsp; Experience:&nbsp; 3-5 years of administrative&nbsp;experience&nbsp;&nbsp; &nbsp;Other Qualifications/Skills: &nbsp; Proficiency&nbsp;using Outlook, heavy use of email, calendar, and contacts functions&nbsp; Ability to prepare and edit all types of written correspondence, including contract documents, presentations, and spreadsheets, employ&nbsp;formatting skills using Word, Excel, PowerPoint, and SharePoint file management&nbsp; Good Judgement and&nbsp;Discretion: The office of the CEO handles sensitive information&nbsp;and&nbsp;often works on plans well in advance of public knowledge.&nbsp;The Administrative Assistant must hold matters&nbsp;in&nbsp;confidence&nbsp;and protect confidential&nbsp;information.&nbsp; Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical Requirements -&nbsp;Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only occasionally, and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work).&nbsp; Base salary compensation range:&nbsp;$36.05-45.19/hourly&nbsp;&nbsp; Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Administrative Assistant (Contractor)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY&nbsp; The incumbent provides strategic statistical input to and&nbsp;oversees&nbsp;all statistical aspects of assigned programs; drives cross-functional collaboration and decision making for program(s); oversees the performance of Contract Research Organizations (CROs); develop and mentor other statisticians.&nbsp; &nbsp;MAJOR DUTIES &amp;&nbsp;RESPONSIBILITIES:&nbsp; Ensures expert level contribution to strategy (design, analysis/synthesis, interpretation and reporting, health authority response, influence and implement publication strategy, quantitative decision making) for critical studies in a program&nbsp; Leads collaborations with clinical,&nbsp;regulatory&nbsp;and other strategic functions to drive quantitative decision making and enables successful impact on robust drug development plans&nbsp; Maintains&nbsp;indication&nbsp;specific standards with respect to key variables, variable definitions, statistical methods, data&nbsp;structures&nbsp;and presentation of results.&nbsp; Provides oversight and guidance to staff members within 4DMT and in CROs in completing high quality study deliverables according to agreed timelines following quality standards.&nbsp; Leads and/or&nbsp;participates&nbsp;in the development and review of Policies, SOPs and other controlled documents for process improvement and operational efficiency.&nbsp; Supports the preparation and validation of statistical analyses for use in regulatory documents and scientific articles. Support internal&nbsp;ad-hoc&nbsp;and&nbsp;exploratory&nbsp;analysis.&nbsp; Plays a critical role in shaping team development and contributing to departmental strategy.&nbsp; Stays abreast of and contributes to scientific advances in the field.&nbsp; Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time &nbsp; &nbsp;QUALIFICATIONS: &nbsp; Education: &nbsp; M.S.&nbsp;required&nbsp; PhD preferred&nbsp; &nbsp;Experience: &nbsp; 10+ years of pharmaceutical industry experience with a PhD, or 12+ years with an MS.&nbsp; Hands-on familiarity with common and advanced statistical&nbsp;methodology.&nbsp; Hands-on experience working with CDISC standards and programming based on raw datasets, SDTM, and&nbsp;ADaM&nbsp;datasets.&nbsp; &nbsp;Other Qualifications/Skills: &nbsp; Strong knowledge of SAS programming concepts and techniques in the pharmaceutical;&nbsp;proficiency&nbsp;in tools such as SAS, EAST, and&nbsp;nQuery.&nbsp; Knowledge/experience of Retinal development, including global regulatory requirements and design and analysis of non-inferiority trials&nbsp; &nbsp;Travel: &lt; 5%&nbsp; &nbsp;Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical Requirements -&nbsp;Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work).&nbsp; Base salary compensation range: $276,000 - 319,000&nbsp; Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Director, Biostatistics

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The Senior Manager, Data Management leads execution of end‑to‑end clinical data management activities for assigned studies and provides operational oversight to internal staff and external vendors. This role serves as a key member of cross‑functional study teams, contributing to planning, execution, and delivery of high‑quality clinical trial data across all phases. The Senior Manager possesses robust working knowledge of clinical data management processes and independently executes most tasks while also providing guidance to other Data Managers and vendor partners. Data management is one of the essential functions of the Clinical Development organization at 4DMT. Together with the other two functions within the Data Science group, Biostatistics, and Statistical Programming, we provide critical support for the company’s clinical development programs in gene therapies for retina diseases and other therapeutic areas. MAJOR DUTIES &amp; RESPONSIBILITIES: Manage end‑to‑end Data Management activities for one or more clinical studies with moderate guidance from line manager. Oversee daily study‑level data management operations, ensuring compliance to timelines, quality standards, and SOPs. Support vendor oversight activities, including reviewing timelines, deliverables, and quality metrics. Contribute to risk identification and mitigation strategies for data‑related issues. Review study protocols to ensure appropriate data capture elements and eCRF design. Support the development of eCRF specifications and contribute to review of data requirements. Assist in coordinating EDC system design, testing, and UAT, ensuring adherence to company standards. Contribute and/or author Data Management Plans, Data Transfer Plans, and other study‑related documents Support review of clinical monitoring plans, SAPs, and vendor specifications. Monitor data quality and cleaning activities, including management of data listings and reconciliation efforts. Partner with CROs and external vendors to ensure timely and high‑quality data deliverables. Participate in study team meetings, providing updates on Data Management metrics and timelines. Escalate issues appropriately to line manager, data management leadership or other functional leads. Oversee reconciliation activities (e.g., header data, SAE reconciliation) performed by CROs. Support database upgrades and migrations, including contribution to UAT. Participate in database snapshot, lock, and freeze activities. Provide day‑to‑day guidance and mentorship to Data Managers. Deliver training to internal and external team members on EDC systems or eCRF completion guidelines as needed. Maintain Data Management documentation and eTMF files. Other duties assigned: nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. QUALIFICATIONS: Education: B.A./B.S. degree or higher (life-science-related fields preferred) or equivalent experience. Experience: 7+ years of data management experience in the biotech/pharmaceutical industry or clinical data management service providers of which at least three (3+) years in a lead study data manager role. Experience with Phase 1-3 clinical trials required: retina diseases and/or gene therapies experience a plus. Demonstrated experience in vendor oversight and cross‑functional team leadership. Experience in vendor management and performance assessments In-depth knowledge and experience with CDISC data standards and models. Other Qualifications/Skills: Proficient in using clinical data management systems (e.g., Medidata Rave) and the data flow, including those from external sources (IRT, safety, central/specialty labs, reading centers, PROs, etc.) Proficiency in data management process and knowledge of Good Clinical Data Management Practices (GCDMP) in global clinical trials Knowledge of ICH GCP and other applicable regulatory rules and guidelines. Knowledge of the clinical development process Proficient with MS Office (Worl, Excel, PowerPoint, etc.) Strong communication and interpersonal skills (written and verbal) Collaborative mindset with ability to work effectively. High attention to detail with excellent organizational and time‑management capabilities. Ability to manage multiple projects in a fast-paced environment Proven conceptual, analytical and strategic thinking Excellent attention to details Travel: 0-10%, based on study needs. Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range:&nbsp;$178,000 - 208,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Manager, Data Management

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: &nbsp; The&nbsp;Director of&nbsp;Statistical Programming&nbsp;will focus on applying programming&nbsp;methodology&nbsp;for implementing statistical analyses using SAS for in-house deliverables and performing quality review of outsourced statistical deliverables.&nbsp;&nbsp;They will&nbsp;participate&nbsp;as active members of a cross-functional team to plan,&nbsp;lead&nbsp;and execute the tasks&nbsp;required&nbsp;to support the assigned programs.&nbsp;&nbsp;&nbsp; MAJOR DUTIES &amp;&nbsp;RESPONSIBILITIES: &nbsp; Provide statistical programming&nbsp;leadership&nbsp;for an assigned&nbsp;indication&nbsp;that may consist of&nbsp;multiple clinical trials&nbsp; Work closely with biostatisticians to review the SAP, and responsible in the development of data/analysis program specification based on the SAP&nbsp; Maintain complete and auditable programming documentations for analysis of clinical trials&nbsp; Contribute to the development,&nbsp;documentation&nbsp;and maintenance of reusable programming code library&nbsp; Collaborate with IT to set-up/maintain&nbsp;the statistical computing infrastructure (e.g., SAS server)&nbsp; May act as a biostatistician on small-scale projects&nbsp; Collaborate with various functions to ensure robust CRF/EDC development, and quality data collection for the assigned clinical trials&nbsp; Oversee the biometrics vendors to ensure the prompt and quality statistical deliverables&nbsp; Provide quality review of outsourced statistical deliverables (including inhouse double programming to QC as needed) and coordinate the inhouse review comments&nbsp; Contribute to the development of functional-level standards, SOPs, and work instructions and templates&nbsp; Stay abreast of industry development in biostatistics/statistical programming fields and apply to&nbsp;appropriate systems&nbsp;and processes&nbsp; Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.&nbsp; &nbsp;QUALIFICATIONS: &nbsp; Education: &nbsp; B.A./B.S.&nbsp;degree&nbsp;in statistics, computer science, or other quantitative science major&nbsp;required&nbsp; Advanced degree (M.A./M.S.) preferred,&nbsp;or equivalent experience&nbsp; Experience: &nbsp; B.A./B.S. with 17+ years, or M.A./M.S. with 13+ years&nbsp; Submission&nbsp;&nbsp; Experience in ophthalmology and/or biologic/gene therapy a plus&nbsp; &nbsp;Other Qualifications/Skills:&nbsp; Strong SAS programming skills required with&nbsp;proficiency&nbsp;in SAS/BASE, SAS Macros, SAS/Stat and ODS (proficiency&nbsp;in SAS/SQL, SAS/GRAPH or SAS/ACCESS is a plus)&nbsp;&nbsp; Proficiency&nbsp;in R programming a plus&nbsp; Proficiency&nbsp;in Microsoft Office Apps, such as WORD, EXCEL, and PowerPoint (familiar with the “Chart” features in EXCEL/PowerPoint a plus)&nbsp;&nbsp; Good understanding of standards specific to clinical trials such as CDISC, SDTM, and&nbsp;ADaM, MedDRA, WHODRUG&nbsp; Experience with all clinical phases (I, II, III, and IV) is desirable&nbsp; Experience with BLA/IND submissions is strongly desirable&nbsp; Good understanding of regulatory requirements for submission-related activities (e.g., CDISC, CDASH, eCTD) and CRT packages (e.g., XPTs Define/xml, reviewer’s guide, analysis metadata report, executable programs) is desirable&nbsp; Able to run the P21 checks is a plus&nbsp; Knowledge of applicable GCP/FDACHMP//ICH/HIPPA regulations&nbsp; Displays excellent organization and time management skills, excellent attention to detail, and ability to multi-task in a fast-paced environment with shifting priorities and/or conflicting deadlines&nbsp; Excellent written and verbal communication skills and&nbsp;strong team&nbsp;player with&nbsp;demonstrated&nbsp;track record&nbsp;of success in cross-functional team environment&nbsp;&nbsp; Proven conceptual,&nbsp;analytical&nbsp;and strategic thinking&nbsp; Good interpersonal and project management skills&nbsp; Proactively&nbsp;identifies&nbsp;risks, issues, and&nbsp;possible solutions&nbsp; Travel:&nbsp;&lt;5%&nbsp; &nbsp; Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical Requirements -&nbsp;Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work).&nbsp; Base salary compensation range: $228,000 - 256,000 Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Statistical Programming

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery&nbsp;GENERAL SUMMARY:&nbsp; The Director, Data Solutions &amp; Optimization leads the development and execution of data solutions initiatives, overseeing EDC solutions vendors, managing clinical and EDC programming, database management, and data analytics. This role will manage and optimize key processes within data management and lead technological strategies, collaborating with internal teams and external vendors to drive innovation and operational efficiency. This role will play a pivotal role in aligning technological advancements with business goals, ensuring high-quality, timely delivery of critical clinical trial data.&nbsp; Data&nbsp;management is one of the essential functions of&nbsp;the Clinical Development organization&nbsp;at 4DMT.&nbsp;Together with&nbsp;the other two functions&nbsp;within&nbsp;the&nbsp;Data Science group, Biostatistics,&nbsp;and Statistical Programming,&nbsp;we provide critical support&nbsp;for&nbsp;the company’s clinical development&nbsp;programs in gene&nbsp;therapies&nbsp;for retina diseases and other therapeutic&nbsp;areas.&nbsp; MAJOR DUTIES &amp;&nbsp;RESPONSIBILITIES:&nbsp;&nbsp; Lead and manage Data Solutions &amp; Optimization, including clinical programming, EDC programming, data analytics, and visualization functions.&nbsp; Develop and implement strategies for&nbsp;optimizing&nbsp;data flow, database builds, and integration of external technologies.&nbsp; Drive&nbsp;the development of technical initiatives, including EDC integration,&nbsp;participate&nbsp;in specification review &amp;/or development of&nbsp;Spotfire visualizations, data currency and cleanliness metrics and visualizations, and other&nbsp;solutions&nbsp;in partnership with IT System Owner &amp; other key stakeholders.&nbsp; Ensure&nbsp;the EDC platform&nbsp;is a qualified and validated system&nbsp;and manage the impact analysis of system updates, ensuring ongoing system optimization, risk mitigation, and cross-functional awareness.&nbsp; Lead data standards initiatives including data cleaning and reporting tools and standard CRFs and edit checks, ensuring alignment with current CDISC SDTM standards.&nbsp;&nbsp; Drive process improvements, workflow optimizations, and the development of new SOPs to enhance operational efficiency.&nbsp; Provide strategic oversight and support&nbsp;of&nbsp;high-priority projects, including database builds, freezes, and locks, user access management for data systems, and evaluation of system updates.&nbsp; Mentor and develop team members, fostering a culture of continuous learning and growth within the team.&nbsp; Ensure compliance with all relevant data privacy regulations and&nbsp;maintain&nbsp;the security of clinical trial data.&nbsp; Collaborate with other departments&nbsp;(i.e., IT, Clinical Operations, Clinical Science, etc.)&nbsp;to align data strategies with broader organizational goals and&nbsp;objectives.&nbsp; Function as&nbsp;a key stakeholder in developing and executing strategies to accelerate drug development through innovative data management practices.&nbsp; Other duties assigned: nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; B.A./B.S.&nbsp;degree&nbsp;or higher&nbsp;(life-science-related&nbsp;fields preferred),&nbsp;or equivalent experience.&nbsp; Experience:&nbsp; 10+ years of progressive experience in data management within biotech/pharma, including at least 5 years in a leadership role.&nbsp; Proven&nbsp;history&nbsp;of leading Data Programming for global clinical trials across all phases.&nbsp; Direct&nbsp;operational experience as Data Programming Lead in all phases of clinical trials, including development/deployment/validation/maintenance/closeout of a clinical database, coordination of data transfers/reconciliations, training on data management systems, etc.&nbsp; Knowledge of FDA and EMA regulations, including 21 CFR Part 11, Parts 210/211, EU Annex 11, CSA principles, and GDPR.&nbsp;&nbsp; Experience in oversight of CRO programming resources and performance assessments (FSP oversight experience is a plus).&nbsp;&nbsp; Expertise&nbsp;in Data Governance Execution and Framework&nbsp; Extensive knowledge of CDISC standards, including CDASH and SDTM.&nbsp;&nbsp; Experience in retina diseases and/or gene therapies&nbsp;is&nbsp;a plus.&nbsp; &nbsp;Other Qualifications/Skills:&nbsp; Strong leadership and team-building skills with&nbsp;ability&nbsp;to influence across functions.&nbsp; Strategic thinker with operational excellence mindset&nbsp;&nbsp; Proficient in using&nbsp;data management systems (e.g., Medidata Rave, Veeva) and data flow, including those from external sources (IRT, safety, central/specialty labs, reading centers, PROs, etc.)&nbsp; Proficiency&nbsp;in data management process and knowledge of Good Clinical Data Management Practices (GCDMP) in global clinical trials&nbsp;&nbsp; Knowledge of ICH GCP and other applicable regulatory rules and guidelines.&nbsp;&nbsp; Understand drug development&nbsp;process&nbsp;and risk-based trail management concepts.&nbsp; Proficient with MS Office (Worl, Excel, PowerPoint, etc.)&nbsp; Exceptional communication and stakeholder management skills.&nbsp; Innate collaborative attitude, with&nbsp;demonstrated&nbsp;ability to work effectively in a small company environment that moves at a tremendous pace.&nbsp; Excellent organization and project/time management skills&nbsp; Ability to multitask in a high-volume environment with shifting priority and conflicting deadlines&nbsp; Proven conceptual,&nbsp;analytical,&nbsp;and strategic thinking&nbsp; Excellent attention to details&nbsp; &nbsp;Travel:&nbsp;5%&nbsp; &nbsp;Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only occasionally, and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work).&nbsp; &nbsp;Base salary compensation range: $214,000 - 250,000 Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience.&nbsp;&nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Data Solutions and Optimization

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Associate Director, QA Computer System Validation (QA CSV) is responsible for overseeing the validation, compliance, and lifecycle management of GxP computerized systems. This role ensures systems are compliant with applicable regulations and industry standards (e.g., FDA 21CFRPart11, EU Annex 11, GAMP 5, applicable ICH Guidelines) and supports business objectives through risk-based, compliant validation strategies. The position provides strategic QA leadership, partners cross-functionally with business partners and IT vendors to ensure appropriate Quality oversight of CSV activities and data integrity controls throughout the lifecycle of 4DMT’s GxP computerized systems. &nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: Provide QA oversight and support business and CSV activities throughout the lifecycle of GxP computerized systems. Review and approve CSV deliverables, IT change management requests, and quality records (e.g., NCRs CAPAs) to ensure adherence to 4DMT’s internal procedures and policies, and applicable regulatory requirements and standards. Review plans and provide day-to-day QA guidance and support to initial validation, steady state activities and controlled change-related initiatives of GxP systems. Serve as a subject matter expert (SME) in CSV requirements, data integrity controls, and related regulatory requirements / standards, including FDA 21 CFR Part 11, EU Annex 11, GAMP 5, and applicable ICH Guidelines. Develop and/or refine QA and CSV-related procedures and templates. Support audits for qualification and requalification of IT vendors. Collaborate across functions and within Quality to identify areas of improvement and implement enhancements. Support inspection readiness initiatives, audits and regulatory inspections. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; Bachelor’s degree in life sciences, business or related field. Experience:&nbsp; 9+ years of experience within the biopharmaceutical industry, preferable in both large and small company environments &nbsp; 6+ years’ experience in QA CSV Thorough working knowledge of computer systems validation and computer software assurance. Expertise in 21CFRPart11 and EU Annex 11 regulations, data integrity and GAMP 5 concepts, application and best practices. Hands-on experience in implementing and maintaining data integrity controls. Experience supporting regulatory inspections and audits. Demonstrated ability to apply risk-based approaches to information system selection, testing, implementation and maintenance. Other Qualifications/Skills:&nbsp; Experience working with all levels of management and consulting with key business stakeholders. &nbsp; Strong team player that has a customer service approach and is solution oriented. Attention to detail and the ability to work independently, within a multi-disciplinary team, as well as with external partners and vendors. Excellent written and verbal communication skills; strong interpersonal skills. Travel: As needed, less than 5% Base salary compensation range: $169,000 - 197,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Director, QA Computer System Validation

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY 4DMT seeks a motivated and experienced Senior Clinical Trial Associate to support the Company's clinical trial activities.&nbsp; This position reports to the Sr. CTM, Clinical Operations and will be responsible for supporting the day-to-day operations of a phase 3 clinical trial including trial start up, conduct and close-out activities.&nbsp; This role requires strong, professional written and verbal communication skills, good organization and attention to detail, and the ability to consistently provide high quality work while managing competing priorities and maintaining tight timelines.&nbsp; This person must be interested in working in a fast-paced, team-oriented environment and be willing to work beyond their job scope to achieve department and company objectives. MAJOR DUTIES &amp; RESPONSIBILITIES: Tracking All Aspects and Activities of a Clinical Trial: Collect, track and conduct initial review for completeness of site regulatory documents for IP release and/or TMF filing Maintain multiple tracking spreadsheets following the progress of assigned clinical trials, such as study subject tracking, essential document tracking, and sample and investigational product tracking Track and coordinate CRO and third-party vendor activities, including vendor provided meeting minutes, study updates and trackers Assist with tracking of clinical trial progress including status update reports, as requested Assist in tracking of trial IP Assist in tracking of clinical lab samples and central reader/lab data, including tracking of sample shipments and reconciliation May assist CTM in tracking and follow-up of monitoring visit reports and unresolved issues Contracts and Finance Activities&nbsp;: Facilitate review and execution of new CDAs, contracts and Work Orders through established legal approval process (CTAs, MSAs, work/task orders) Perform first pass review of all site and vendor invoices including tracking and generation of monthly/quarterly accruals for finance Clinical Trial Communications: Communicate directly with sites, Contract Research Organizations (CROs) and field CRA/monitors to obtain updated information, essential documents, etc. to assist with driving start-up, study conduct, and/or close-out activities&nbsp;&nbsp; Assist with the organization, management and conduct of internal team meetings, investigator meetings and other trial-specific meetings, including minute taking and action item log tracking&nbsp;&nbsp; Document Review and Quality Control: Receive and review all regulatory documents from sites (direct or through CRO) for accuracy and compliance to applicable SOPs and regulatory guidelines Ensure timely updates are provided to CTM for updating of ‘Clinicaltrial.gov’ (site updates/changes) Assist with the development of site tools and clinical trial start-up activities Assist and/or contribute to the creation and maintenance of study materials for clinical studies, including but not limited to site and CRA training material, regulatory document templates, study binders, study plans/manuals, study communications and presentations Organize, maintain and participate in audits and close out of the Trial Master File (TMF/eTMF) Miscellaneous Activities: Participate in the EDC specification and user acceptance testing processes, as appropriate Other duties may be assigned Willingness to travel as trial needs demand (&lt;5% anticipated) QUALIFICATIONS: Education: A./B.S. degree required Experience: At least 2 years of work experience supporting clinical trials Other Qualifications/Skills: Must be proficient with TMF and Veeva Vault Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, and Outlook Ability to prioritize and manage competing priorities Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners Basic knowledge of clinical trial operations, ICH GCP Guidelines and other applicable regulatory requirements Travel: % Willing to travel as business needs demand (&lt;5% anticipated) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range:&nbsp;$90,000 - 130,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Clinical Trial Associate

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY We are seeking a TMF Quality &amp; Oversight Specialist, reporting to the Director of TMF Operations. This contractor will support the review, quality oversight, and maintenance of Trial Master File (TMF) documentation in accordance with GCP, ICH E6, regulatory requirements, and 4DMT SOPs. In addition to QC review, the role will help develop and execute Oversight Review processes in Veeva Vault eTMF and support system change requests by representing the Business Process Owner (BPO) perspective. This work is critical to strengthening TMF oversight and ensuring inspection readiness. MAJOR DUTIES &amp; RESPONSIBILITIES: QC Review &amp; Documentation Support Perform detailed QC reviews of TMF documents to verify metadata accuracy, confirm proper filing, and ensure compliance with ICH GCP, regulatory standards, and internal SOPs. Identify documentation gaps, inconsistencies, or quality issues and collaborate with TMF Operations team members to resolve them promptly. Support ongoing TMF review activities throughout the study lifecycle to help ensure quality, timeliness, and completeness. Assist with audit and inspection preparation by supporting the TMF team in documentation readiness activities. Oversight Review Process Development Contribute to the continuous improvement of Oversight Review processes within Veeva Vault eTMF, including workflows, dashboards, and metrics. Support the development of review standards, success metrics, and monitoring tools that provide visibility into TMF quality, completeness, and inspection readiness. Support TMF Operations leadership in identifying process improvement opportunities and contributing to the development of new tools, workflows, and best practices. Business Process Owner (BPO) Support for System Enhancements Assist in preparing business requirements, documenting user needs, and participating in validation testing and user acceptance activities from the BPO perspective. Provide input into change control documentation and support cross-functional collaboration with IT, Quality, and Managed Services teams during configuration updates. Help develop training materials, reference guides, and user communications to support adoption of new functionality or process changes. QUALIFICATIONS:&nbsp; REQUIRED EXPERIENCE: Minimum 5 years of relevant experience in TMF Operations, including extensive hands-on work with Veeva Vault eTMF. At least 2 years performing TMF QC review, applying knowledge of clinical documentation content and metadata standards. Experience supporting TMF planning, implementation, and configuration activities, including review of TMF Plans and participation in system setup or enhancements. Demonstrated understanding of the CDISC Reference Model, TMF structure, ICH/GCP, Good Documentation Practice, and regulatory documentation requirements. PREFERRED EXPERIENCE: Experience partnering with or overseeing CROs performing TMF activities. Hands-on involvement in system reporting, dashboard development, or configuration testing within Veeva Vault. Exposure to multiple phases of clinical trial conduct (startup through close-out and TMF archiving). Familiarity with additional Veeva products such as CTMS or Vault RIM. REQUIRED SKILLS: Proficiency in Microsoft Office Suite for collaboration with team members. Especially proficient in Excel for tracking, sorting, filtering, and managing large sets of metadata. Interpersonal skills, including conflict resolution in a fast-paced, deadline-driven environment. Strong attention to detail and organizational skills including the ability and drive to follow through on detailed tasks to closure. Analytical skills to evaluate and interpret complex situations/problems using multiple sources of information. Travel: 0% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Hourly Rate: $60.00 &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

TMF Quality Specialist (Contract)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:The Clinical Trial Manager will support the Company's clinical trial activities.&nbsp; This position reports to the Director of Clinical Operations.&nbsp; This will be responsible for management of the day to day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close out activities.&nbsp;&nbsp;MAJOR DUTIES &amp; RESPONSIBILITIES: Trial Management: Serve as the primary contact for managing protocol execution, including oversight of the CRO, other study service providers, and consultants that are involved in a clinical trial Lead cross-functional study execution team in support of study deliverables Support establishment of study milestones and ensure accurate tracking and reporting of study metrics and timelines to leadership Ensure clinical trials are managed and executed in accordance with ICH GCP, regulations, the protocol, and company-specific SOPs Assist in preparation and review of clinical trial documentation such as; protocol, informed consent, Investigator Brochure, Clinical Monitoring Plan, Project Plan, Case Report Forms, Statistical Analysis Plan, Clinical Study Reports, and other study level documents Ensure that the Trial Master File (TMF) is set up and maintained appropriately throughout the trial, including periodic reviews Participate and coordinate resolution of audit finding and ensures audit-ready condition of clinical trial documentation including central clinical files Participates in service provider selection process as a part of outsourcing activities Proactively identifies, with the support and guidance from Senior Clinical Operations staff, and supports development of plans and resolution of project issues and participates in process improvement initiatives as required Supports&nbsp;assessing operational feasibility, recommending study execution plan and site selection under the Director of Clinical Operations Responsible for the selection and study specific training of CRO study staff, monitors, investigational sites, and service providers In conjunction with legal &nbsp;group, &nbsp;facilitate &nbsp;the &nbsp;development &nbsp;of &nbsp;clinical &nbsp;trial agreements and other relevant documents Manage clinical trial budgets, providing ongoing financial reporting and projections Negotiate and finalize site contracts and budgets Perform and manage data review process on an ongoing basis Perform site visits including site qualification, initiation, monitoring and close-out visits, as needed Oversee outsourced monitoring by reviewing, monitoring reports to ensure quality and resolution of site-related issues Ensures tracking and review of protocol deviations and assesses impact on study data Develops and manages study budget and maintain within financial goals; Reviews and approves clinical invoices against approved budget Provides oversight for forecasting of clinical supplies, including study drug and supplies &nbsp;Department Management: May manage and/or oversee work of junior Clinical Operations staff May support development and review of Clinical SOPs and other department initiatives Travel as needed to sites, conferences, industry meetings Other duties as may be assigned QUALIFICATIONS: Education: B.A./B.S. degree Experience: 6+ years of clinical research experience within the Biotech or similar industry, with at least 2 years directly supporting clinical trial management Other Qualifications/Skills: (non-technical and technical skills) Knowledge of GCP, ICH guidelines and regulatory requirements for clinical trial management; Strong clinical study management skills Understanding of, and experience with, regulatory framework applicable to interactions with HCPs, payers, advocacy and other business partners Proven clinical operational skills to direct protocol execution to ensure timeline, budget and quality metrics are met Excellent communication skills to effectively disseminate information to project team and outside parties Experience reviewing trial plans including developing creative strategies for site monitoring, risk mitigation, trial budgets, site selection, and clinical supplies management Clinical research knowledge and cross-functional understanding of clinical trial methodology Excellent organizational, conflict resolution, prioritization and negotiation skills &nbsp; Proven ability in creative problem-solving and exercising sound judgment Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners Ability to handle a high volume of highly complex tasks within a given timeline Ability to develop Therapeutic Areas knowledge and expertise through internal training and external conference attendance Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, and Outlook Working knowledge of MS Project for development and update of clinical study timelines Travel: 5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $150,000 - 178,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Clinical Trial Manager

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Director, Clinical Science will be integral in facilitating the successful advancement of clinical gene therapy programs. The position supports clinical and scientific aspects of all assigned clinical programs. MAJOR DUTIES &amp; RESPONSIBILITIES: Partner with cross-functional program team members and key R&amp;D stakeholders to support the development of innovative study designs, clinical trial protocols and amendments, investigator brochures, and other documents required to conduct clinical trials. Provide clinical support for clinical study conduct, including operational feasibility, data management, communication plans, safety and medical monitoring, preparation of meeting materials, and study updates. Provide scientific support and cleaning/querying of key safety and efficacy data for ongoing clinical trials throughout conduct. Prepare and communicate clear overviews of trial results. Identify issues related to study conduct and/or subject safety. Provide preliminary assessments and recommendations and collaborate with the clinical team to develop solutions to ensure resolution. Interact with internal and external stakeholders (study sites, vendors, KOLs, etc.) in support of program-level strategy as well as clinical trial objectives. Act as a recognized clinical expert for assigned programs. Contribute to the preparation of medical and scientific data for publications, presentations, and study milestones (including meetings for the Executive Team, Board of Directors, Advisory Boards, and the Data and Safety Monitoring Committees [DSMC]) Together with the Therapeutic Area Head for Lung, serve as a point of contact for the clinical operations personnel, clinical trial sites, and CROs for clinical science questions Maintains knowledge of ICH-GCP and FDA IND, and external regulations and procedures. Contribute to authoring clinical documents such as protocol synopsis, clinical study reports, IBs, ICFs, training documents, and others. Author pertinent clinical sections of regulatory filings, including preparation of routine correspondence and sections of INDs, BLAs, NDAs, Annual Reports, Amendments, Supplements, Orphan Drug Applications, and other regulatory submissions Ability to travel, approximately 5%. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS:&nbsp; Education:&nbsp; M.S. in a biological/health science field required Degrees such as OD, PhD, or PharmD preferred Experience:&nbsp; M.S. with 8+ years Clinical science experience with 5+ years of drug development, or OD/PhD or PharmD with 5+ years of experience Other Qualifications/Skills:&nbsp; Ability to interpret, analyze, and present clinical data Thorough understanding of the drug development process Broad understanding of functional areas of drug development, including preclinical, regulatory, pharmacovigilance, drug supply, data sciences (data management, biostatistics, programming), and clinical operations (including site selection, study start-up, study conduct, and finalization). Demonstrated ability to communicate and write clearly, concisely, and effectively. Ability to understand, interpret and communicate clinical information including literature reviews, competitive intelligence, and changing treatment paradigms in order to apply knowledge to support a robust clinical development strategy. Understanding of trial design and statistics Well-organized: ability to prioritize tasks with a successful track record of managing multiple projects in a fast-paced and deadline-driven environment. Good leadership and management skills to manage internal and external collaborations and work well within cross-disciplinary teams. Travel: 5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $219,000 - 264,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Clinical Science

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The Scientist position in Biomarkers &amp; Immunology department will be the technical subject matter expert and lab lead for the histology team, support biobank activities and cross train in molecular biology and other techniques.&nbsp; This entails taking on challenging projects and completing them in a timely manner with focus on excellence and attention to detail.&nbsp; These projects will include (but are not limited to) IHC/ISH/IF assay development and study execution, Visiopharm image analysis app development and data analysis/interpretation, biobank sample repository support and willingness to learn new methodology to support the BI team.&nbsp; The Scientist will be expected to mentor and train junior team members in techniques and methods in which they have expertise.&nbsp; Working closely with diverse groups on cross functional teams, (such as Early-Stage Product Development, Project Management, Clinical Sciences, and Clinical Development) our data deliverables impact important program decisions.&nbsp; This role will report to the Senior Director of Biomarkers and Immunology and be part of a talented, motivated, and creative team of scientists who are critical for the success of 4DMT’s mission and development of our deep portfolio of targeted genetic medicines. While on-site presence is required to perform laboratory work, a flexible hybrid work schedule can be accommodated when analyzing data and remotely managing partner organizations.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: Independent method development of automated ISH/IHC/IF histology biomarker assays Independent sample testing design/execution/interpretation/reporting of diverse histology biomarker studies Visiopharm image analysis app development and execution Development of complex multiplex IF methodology Supporting internal biobiank project by receiving/accessioning, distributing and maintaining samples/inventories Cross-training with and supporting molecular biology and ligand binding assay subject matter experts Effective data summary and presentation to project teams and externally Leadership including cross training BI team members in areas of expertise Integration/participation in cross functional teams Leading and supporting research initiatives such as new technology development and platform improvement projects&nbsp; Writing study reports and manuscripts and presenting results at scientific meetings&nbsp; Maintaining compliance with company Environmental Health and Safety policies, procedures, and practices Contributing to building a culture that embraces continuous learning, improvement, and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise.&nbsp; QUALIFICATIONS:&nbsp; Education: Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field&nbsp; Master’s degree with 2+ years, bachelor’s with 4+ years&nbsp;or PHD with 1+ years of experience Experience: Immunohistochemistry automated assay development In situ hybridization automated assay development Experience in design and execution of complex image analysis using Visiopharm software Experience/troubleshooting common histology techniques (microtomy, grossing, embedding, H&amp;E staining, special stains, pathology/anatomy) Proficiency with automated slide scanning and digital slide inventory programs Familiarity with CAP/CLIA standards for pathology labs/experiments Molecular biology and/or ligand binding assay (ELISA) techniques Excellent data summary/presentation skills Prior experience with bioanalytical or biomarker assay development is strongly preferred Successfully demonstrated ability to work independently in designing, developing, and executing new assay methods Successfully demonstrated ability to conduct research with strong attention to detail and rigorously analyze and interpret data Ability to multi-task and support more than one project simultaneously Highly organized and motivated; strong analytical, organizational, and problem-solving skills Strong work ethic, flexibility, and cooperative can-do attitude Ability to work cooperatively in a team-based environment; supportive of multiple viewpoints and approaches Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively via one-on-one discussions, team meetings, and external partnership interactions Understanding and knowledge of key scientific software programs (including Microsoft Office, JMP or Prism, Adobe Photoshop).&nbsp; Travel: &lt;5% Physical Requirements and Working Conditions: Lifting up to 20 lbs, bending, lifting, twisting, ability to wear Personal Protective Equipment such as lab coat, goggles/glasses, and nitrile gloves&nbsp; Flexible work schedule allowing productive remote work 2+ days per week Base salary compensation range: $131,000 - $143,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Scientist

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:The Clinical Trial Manager will support the Company's clinical trial activities.&nbsp; This position reports to the Director of Clinical Operations.&nbsp; This will be responsible for management of the day to day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close out activities.&nbsp;&nbsp;MAJOR DUTIES &amp; RESPONSIBILITIES: Trial Management: Serve as the primary contact for managing protocol execution, including oversight of the CRO, other study service providers, and consultants that are involved in a clinical trial Lead cross-functional study execution team in support of study deliverables Support establishment of study milestones and ensure accurate tracking and reporting of study metrics and timelines to leadership Ensure clinical trials are managed and executed in accordance with ICH GCP, regulations, the protocol, and company-specific SOPs Assist in preparation and review of clinical trial documentation such as; protocol, informed consent, Investigator Brochure, Clinical Monitoring Plan, Project Plan, Case Report Forms, Statistical Analysis Plan, Clinical Study Reports, and other study level documents Ensure that the Trial Master File (TMF) is set up and maintained appropriately throughout the trial, including periodic reviews Participate and coordinate resolution of audit finding and ensures audit-ready condition of clinical trial documentation including central clinical files Participates in service provider selection process as a part of outsourcing activities Proactively identifies, with the support and guidance from Senior Clinical Operations staff, and supports development of plans and resolution of project issues and participates in process improvement initiatives as required Supports&nbsp;assessing operational feasibility, recommending study execution plan and site selection under the Director of Clinical Operations Responsible for the selection and study specific training of CRO study staff, monitors, investigational sites, and service providers In conjunction with legal &nbsp;group, &nbsp;facilitate &nbsp;the &nbsp;development &nbsp;of &nbsp;clinical &nbsp;trial agreements and other relevant documents Manage clinical trial budgets, providing ongoing financial reporting and projections Negotiate and finalize site contracts and budgets Perform and manage data review process on an ongoing basis Perform site visits including site qualification, initiation, monitoring and close-out visits, as needed Oversee outsourced monitoring by reviewing, monitoring reports to ensure quality and resolution of site-related issues Ensures tracking and review of protocol deviations and assesses impact on study data Develops and manages study budget and maintain within financial goals; Reviews and approves clinical invoices against approved budget Provides oversight for forecasting of clinical supplies, including study drug and supplies &nbsp;Department Management: May manage and/or oversee work of junior Clinical Operations staff May support development and review of Clinical SOPs and other department initiatives Travel as needed to sites, conferences, industry meetings Other duties as may be assigned QUALIFICATIONS: Education: B.A./B.S. degree Experience: 6+ years of clinical research experience within the Biotech or similar industry, with at least 2 years directly supporting clinical trial management Other Qualifications/Skills: (non-technical and technical skills) Knowledge of GCP, ICH guidelines and regulatory requirements for clinical trial management; Strong clinical study management skills Understanding of, and experience with, regulatory framework applicable to interactions with HCPs, payers, advocacy and other business partners Proven clinical operational skills to direct protocol execution to ensure timeline, budget and quality metrics are met Excellent communication skills to effectively disseminate information to project team and outside parties Experience reviewing trial plans including developing creative strategies for site monitoring, risk mitigation, trial budgets, site selection, and clinical supplies management Clinical research knowledge and cross-functional understanding of clinical trial methodology Excellent organizational, conflict resolution, prioritization and negotiation skills &nbsp; Proven ability in creative problem-solving and exercising sound judgment Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners Ability to handle a high volume of highly complex tasks within a given timeline Ability to develop Therapeutic Areas knowledge and expertise through internal training and external conference attendance Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, and Outlook Working knowledge of MS Project for development and update of clinical study timelines Travel: 5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $150,000 - 172,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY 4DMT seeks a motivated and experienced Senior Clinical Trial Associate to support the Company's clinical trial activities.&nbsp; This position reports to the Director, Clinical Operations, Retina and will be responsible for supporting the day-to-day operations of a phase 3 clinical trial including trial start up, conduct and close-out activities.&nbsp; This role requires strong, professional written and verbal communication skills, good organization and attention to detail, and the ability to consistently provide high quality work while managing competing priorities and maintaining tight timelines.&nbsp; This person must be interested in working in a fast-paced, team-oriented environment and be willing to work beyond their job scope to achieve department and company objectives. MAJOR DUTIES &amp; RESPONSIBILITIES: Tracking All Aspects and Activities of a Clinical Trial: Collect, track and conduct initial review for completeness of site regulatory documents for IP release and/or TMF filing Maintain multiple tracking spreadsheets following the progress of assigned clinical trials, such as study subject tracking, essential document tracking, and sample and investigational product tracking Track and coordinate CRO and third-party vendor activities, including vendor provided meeting minutes, study updates and trackers Assist with tracking of clinical trial progress including status update reports, as requested Assist in tracking of trial IP Assist in tracking of clinical lab samples and central reader/lab data, including tracking of sample shipments and reconciliation May assist CTM in tracking and follow-up of monitoring visit reports and unresolved issues Contracts and Finance Activities&nbsp;: Facilitate review and execution of new CDAs, contracts and Work Orders through established legal approval process (CTAs, MSAs, work/task orders) Perform first pass review of all site and vendor invoices including tracking and generation of monthly/quarterly accruals for finance Clinical Trial Communications: Communicate directly with sites, Contract Research Organizations (CROs) and field CRA/monitors to obtain updated information, essential documents, etc. to assist with driving start-up, study conduct, and/or close-out activities&nbsp;&nbsp; Assist with the organization, management and conduct of internal team meetings, investigator meetings and other trial-specific meetings, including minute taking and action item log tracking&nbsp;&nbsp; Document Review and Quality Control: Receive and review all regulatory documents from sites (direct or through CRO) for accuracy and compliance to applicable SOPs and regulatory guidelines Ensure timely updates are provided to CTM for updating of ‘Clinicaltrial.gov’ (site updates/changes) Assist with the development of site tools and clinical trial start-up activities Assist and/or contribute to the creation and maintenance of study materials for clinical studies, including but not limited to site and CRA training material, regulatory document templates, study binders, study plans/manuals, study communications and presentations Organize, maintain and participate in audits and close out of the Trial Master File (TMF/eTMF) Miscellaneous Activities: Participate in the EDC specification and user acceptance testing processes, as appropriate Other duties may be assigned Willingness to travel as trial needs demand (&lt;5% anticipated) QUALIFICATIONS: Education: A./B.S. degree required Experience: At least 2 years of work experience supporting clinical trials Other Qualifications/Skills: Must be proficient with TMF and Veeva Vault Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, and Outlook Ability to prioritize and manage competing priorities Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners Basic knowledge of clinical trial operations, ICH GCP Guidelines and other applicable regulatory requirements Travel: % Willing to travel as business needs demand (&lt;5% anticipated) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $90,000 - 125,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: &nbsp; The Associate Director, Clinical Operations will be responsible for implementation, execution and oversight of all clinical trials within a clinical program, in coordination with cross-functional project teams to ensure that assigned clinical trials are executed on time, within budget, and in compliance with GCP and other applicable guidelines and regulations. &nbsp; &nbsp;MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Partner with Director of Clinical Operations to develop and manage clinical programs in compliance with corporate objectives and timelines &nbsp; Provide operational leadership to the direction, planning, execution and interpretation of clinical trials and data collection by effectively developing and monitoring clinical trial/program timelines, budgets, risks and mitigation plans &nbsp; Provides guidance and mentoring to Clinical Trial Managers (CTMs) and junior level team members in study document development, vendor and study management, study implementation, issue resolution, timelines, budgeting and resourcing &nbsp; Independently oversee day-to-day activities of the Clinical Trial Operations and Clinical Data Management groups &nbsp; Collaborate with Finance/Business Operations on annual budget planning (external spend) as well as quarterly budget reviews and re-forecasts; designing, implementing, and overseeing clinical vendor outsourcing strategy; actively participating in the selection of vendors to support 4DMT clinical trials as well as active governance of them; participating and/or leading vendor governance committees &nbsp; Ensure that each clinical trial is always inspection ready &nbsp; Ensure that each clinical trial is being actively managed by a cross-functional Study Execution Team (SET) &nbsp; May sit on product cross-functional core teams as Clinical Operations SME &nbsp; Partner closely with Quality to ensure that the programs and 4DMT always remain inspection ready &nbsp; Collaborate with Regulatory Affairs and Clinical Sciences on the creation of regulatory submissions and compliance to regulatory requirements (eg, Clincialtrials.gov) &nbsp; Addresses escalated study issues in collaboration with CTMs and senior management as appropriate inclusive of risk mitigation plans &nbsp; Coordinates the development and maintenance of clinical SOPs as pertains to the program and provides review/ input into cross-functional SOPs and other documents &nbsp; Supports development and review of protocols/ amendments, study documents and plans, and operational execution &nbsp; Actively participates in CRO, site and vendor selection in order to ensure that trial responsibilities are appropriately delegated and that partners are aligned with corporate objectives; provides ongoing surveillance of progress and ensures that contingency plans are triggered as and where appropriate &nbsp; Contributes to the development of the Clinical Operations department processes and procedures and will manage clinical resources to ensure effective implementation of trials. &nbsp; QUALIFICATIONS: &nbsp; &nbsp;Education: &nbsp; B.S./B.A. in Life Science or related discipline required &nbsp; Advanced degree (M.S./M.A., MPH, MHS, MBA) preferred. &nbsp; Clinical Research certification preferred, but not required. &nbsp; &nbsp;Experience: &nbsp; B.S./B.A. with 9+ years of industry experience in clinical development with a minimum of 3 years managerial experience, or M.A./M.S. with 4+ years of experience. &nbsp; Require 1+ years ophthalmology trial experience as well as late phase trial experience. Relevant experience in clinical trial execution across all phases &nbsp; &nbsp;Other Qualifications/Skills: &nbsp; Proven ability to recruit, retain, organize, and motivate clinical operations personnel &nbsp; Ability to communicate to Clinical Operations and Development Leadership team updates and priorities as well as to advocate for required budget and resources &nbsp; Ability to manage and oversee programs that have corporate-wide impact &nbsp; Ability to develop and manage functional and clinical trial-specific budgets &nbsp; Must be self-motivating; prioritize and manage a large volume of work; show attention to detail &nbsp; Strong interpersonal skills are essential as this individual will partner with various team members and functional groups for clinical trials and business performance &nbsp; Thorough knowledge and understanding of FDA and ICH Guidelines, GCP, medical terminology, and clinical trials &nbsp; Ability to be flexible and adaptable to changing business needs &nbsp; Excellent communication and interpersonal skills &nbsp; Must be able to write clearly and summarize information effectively &nbsp; Must be able to present complex information to various audiences &nbsp; &nbsp;Travel:&nbsp;Anticipate&nbsp;20%, or as trial needs demand&nbsp; &nbsp;Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical&nbsp;Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $180,000 - 200,000 Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Director, Clinical Operations

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; The Associate Director, Clinical Supply is responsible for projecting, planning, executing, and overseeing all supply chain activities related to clinical trial materials. This includes managing the procurement, production, packaging, labeling, distribution, and inventory of clinical trial materials to meet company goals within the defined timelines. This role ensures that clinical supplies, including investigational product, comparators, auxiliary IMPs, and supplies, are delivered on time, within budget, and in compliance with regulatory requirements. This role involves close collaboration with various departments, including Clinical Operations, Clinical Science, Quality Assurance, Regulatory Affairs, Manufacturing, and external vendors. Effective communication with stakeholders at all levels is required to provide regular updates on supply chain status and address any concerns. Serve as the primary point of contact for clinical supply-related inquiries and issues. RESPONSIBILITIES:&nbsp; Supply Planning and Management: Develop and implement clinical supply strategies to support global clinical trials Lead Phase 1 to 3 clinical trial materials planning and execution. Participate in cross-functional discussions early in the study design phase to ensure that material lead-time is properly built in for overall program timeline. This includes Investigational Products (IP), diluent, comparator drugs, ancillary supplies, or any other clinical materials required and identified by each project team Create detailed supply plans based on trial requirements, enrollment forecasts, and study timelines Oversee material requirements for domestic and international study execution. Ensure procurement, production, packaging, labeling, and distribution of clinical trial materials are done per applicable local and international guidance Inventory Control and Distribution: Manage inventory levels to ensure sufficient supply of clinical trial materials while minimizing waste. Review of clinical supply requests, placing ancillary supply orders, and communicating IP demands Coordinate the distribution of clinical supplies to CMO and study sites, ensuring timely delivery and adherence to protocols. Monitor and track shipment status, resolving any issues that arise during transit. Vendor Management. Identify, select, and manage relationships with suppliers, manufacturers, and logistics providers including CMOs and CROs. Plan and coordinate clinical supply activities including labeling, packaging, distribution of clinical trial supplies, randomization, and drug accountability systems control. Negotiate contracts and service agreements with vendors to ensure cost-effective and high-quality supply chain operations. Project Management: Participate in supply chain business process development project. Drive continuous operational performance improvement efforts. Ensure compliance with Good Manufacturing Practices and applicable state and federal regulatory authorities. Others Generate and maintain various clinical supply inventory reports. Ensure process execution is conducted per internal policy and procedures Identify opportunities for process improvements and implement best practices in clinical supply chain management. Perform other duties as assigned. &nbsp;QUALIFICATIONS:&nbsp; Education:&nbsp; Bachelor’s degree in supply chain or other disciplines with equivalent industry experience Experience:&nbsp; 9+ years of experience in clinical or in combination with commercial supply chain management, with at least 4 years in a senior or managerial role. In-depth knowledge of clinical trial processes, GMP, GCP, and regulatory requirements Proven experience in managing complex global supply chains for clinical trials (including Europe, APAC and South America) Proven experience with high-complexity Phase 3 trials Skills:&nbsp; Strong project management skills, with the ability to lead cross-functional teams and manage multiple priorities. Excellent negotiation, communication, and interpersonal skills. Proficiency in supply chain management software and tools. Strong analytical and problem-solving abilities. Ability to work in a fast-paced, dynamic environment and adapt to changing priorities. Travel: &lt;5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $177,000 - 205,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Director, Clinical Supply

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: &nbsp; The Associate Director, Clinical Operations will be responsible for implementation, execution and oversight of all clinical trials within a clinical program, in coordination with cross-functional project teams to ensure that assigned clinical trials are executed on time, within budget, and in compliance with GCP and other applicable guidelines and regulations. &nbsp; &nbsp;MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Partner with Director of Clinical Operations to develop and manage clinical programs in compliance with corporate objectives and timelines &nbsp; Provide operational leadership to the direction, planning, execution and interpretation of clinical trials and data collection by effectively developing and monitoring clinical trial/program timelines, budgets, risks and mitigation plans &nbsp; Provides guidance and mentoring to Clinical Trial Managers (CTMs) and junior level team members in study document development, vendor and study management, study implementation, issue resolution, timelines, budgeting and resourcing &nbsp; Independently oversee day-to-day activities of the Clinical Trial Operations and Clinical Data Management groups &nbsp; Collaborate with Finance/Business Operations on annual budget planning (external spend) as well as quarterly budget reviews and re-forecasts; designing, implementing, and overseeing clinical vendor outsourcing strategy; actively participating in the selection of vendors to support 4DMT clinical trials as well as active governance of them; participating and/or leading vendor governance committees &nbsp; Ensure that each clinical trial is always inspection ready &nbsp; Ensure that each clinical trial is being actively managed by a cross-functional Study Execution Team (SET) &nbsp; May sit on product cross-functional core teams as Clinical Operations SME &nbsp; Partner closely with Quality to ensure that the programs and 4DMT always remain inspection ready &nbsp; Collaborate with Regulatory Affairs and Clinical Sciences on the creation of regulatory submissions and compliance to regulatory requirements (e.g., Clincialtrials.gov) &nbsp; Addresses escalated study issues in collaboration with CTMs and senior management as appropriate inclusive of risk mitigation plans &nbsp; Coordinates the development and maintenance of clinical SOPs as pertains to the program and provides review/ input into cross-functional SOPs and other documents &nbsp; Supports development and review of protocols/ amendments, study documents and plans, and operational execution &nbsp; Actively participates in CRO, site and vendor selection in order to ensure that trial responsibilities are appropriately delegated and that partners are aligned with corporate objectives; provides ongoing surveillance of progress and ensures that contingency plans are triggered as and where appropriate &nbsp; Contributes to the development of the Clinical Operations department processes and procedures and will manage clinical resources to ensure effective implementation of trials. &nbsp; QUALIFICATIONS: &nbsp; &nbsp;Education: &nbsp; B.S./B.A. in Life Science or related discipline required &nbsp; Advanced degree (M.S./M.A., MPH, MHS, MBA) preferred&nbsp; Clinical Research certification preferred, but not required&nbsp; &nbsp;Experience: &nbsp; B.S./B.A. with 9+ years of industry experience in clinical development with a minimum of 3 years managerial experience, or M.A./M.S. with 4+ years of experience&nbsp; Requires 1+ years ophthalmology trial experience as well as late phase trial experience. Relevant experience in clinical trial execution across all phases &nbsp; &nbsp;Other Qualifications/Skills: &nbsp; Proven ability to recruit, retain, organize, and motivate clinical operations personnel &nbsp; Ability to communicate to Clinical Operations and Development Leadership team updates and priorities as well as to advocate for required budget and resources &nbsp; Ability to manage and oversee programs that have corporate-wide impact &nbsp; Ability to develop and manage functional and clinical trial-specific budgets &nbsp; Must be self-motivating; prioritize and manage a large volume of work; show attention to detail &nbsp; Strong interpersonal skills are essential as this individual will partner with various team members and functional groups for clinical trials and business performance &nbsp; Thorough knowledge and understanding of FDA and ICH Guidelines, GCP, medical terminology, and clinical trials &nbsp; Ability to be flexible and adaptable to changing business needs &nbsp; Excellent communication and interpersonal skills &nbsp; Must be able to write clearly and summarize information effectively &nbsp; Must be able to present complex information to various audiences &nbsp; &nbsp;Travel:&nbsp;Anticipate&nbsp;20%, or as trial needs demand&nbsp; &nbsp;Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical&nbsp;Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $180,000 - 200,000 Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp;&nbsp; 4DMT seeks a motivated and experienced Associate Clinical Trial Manager to support the Company's clinical trial activities.&nbsp; This position will be responsible for supporting the day-to-day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close-out activities.&nbsp; This role requires strong, professional written and verbal communication skills, good organization and attention to detail, and the ability to consistently provide high quality work while managing competing priorities and maintaining tight timelines.&nbsp; This person must be interested in working in a fast-paced, team-oriented environment and be willing to work beyond their job scope to achieve department and company objectives. MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp;&nbsp; Coordinate tracking of a clinical trial(s) under the oversight of the Clinical Trial Management Collect, track and conduct initial review for completeness of site regulatory documents for IP release and/or TMF filing Organize, maintain and participate in audits and close out of the Trial Master File (TMF/eTMF) Maintain multiple tracking spreadsheets following the progress of assigned clinical trials, such as study subject tracking, essential document tracking, and sample and investigational product tracking Track and coordinate CRO and third-party vendor activities, including vendor provided meeting minutes, study updates and trackers Receive and review all regulatory documents from sites (direct or through CRO) for accuracy and compliance to applicable SOPs and regulatory guidelines Ensure timely updates are provided to CTM for updating of ‘Clinicaltrial.gov’ (site updates/changes) Track and route new CDAs, contracts and Work Orders through established legal approval process (CTAs, MSAs, work/task orders) Perform first pass review of all site and vendor invoices including tracking and generation of monthly/quarterly accruals for finance Assist with the development of site tools and clinical trial start-up activities Assist and/or contribute to the creation and maintenance of study materials for clinical studies, including but not limited to site and CRA training material, regulatory document templates, study binders, study plans/manuals, study communications and presentations Assist in tracking of trial IP and development of Pharmacy Manuals Participate in study vendor set up and specification process, as appropriate Communicate directly with sites, Contract Research Organizations (CROs) and CRA/monitors to obtain updated information, essential documents, etc. to assist with driving start-up, study conduct, and/or close-out activities Assist with tracking of clinical trial progress including status update reports, as requested Assist with the organization, management and conduct of internal team meetings, investigator meetings and other trial-specific meetings, including minute taking and action item log tracking Assist in tracking of clinical lab samples and central reader/lab data, including tracking of sample shipments and reconciliation Utilize EDC/CTMS systems to acquire and synthesize data, metrics, or reports as necessary (enrollment data, randomizations, data cleaning, SAEs, etc.) for CTM, specific meetings or management updates May assist CTM in tracking and follow-up of monitoring visit reports and unresolved issues Willing to travel as business needs demand (&lt;5% anticipated) Other duties as may be assigned QUALIFICATIONS:&nbsp;&nbsp; Education: A./B.S. degree required Experience: At least 5 years of work experience supporting clinical trials, with some experience supporting ophthalmology studies (required) Other Qualifications/Skills: Basic knowledge of clinical trial operations, ICH GCP Guidelines and other applicable regulatory requirements Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, SharePoint and Outlook Ability to prioritize and manage competing priorities Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners Travel: 30% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range:&nbsp;$130,000 - 152,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Clinical Trial Manager

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; The Medical Director will lead the design, execution, and analysis of clinical trials in the Ophthalmology therapeutic area, with a focus on retina programs. This role provides strategic and operational clinical leadership across cross-functional study teams and serves as a key medical expert internally and externally. MAJOR DUTIES &amp; RESPONSIBILITIES:&nbsp; Lead clinical strategy and execution for ophthalmology trials, including protocol development, study oversight, and data interpretation. Serve as medical monitor for clinical studies, ensuring patient safety and data integrity. Author and review clinical documents including protocols, IBs, ICFs, INDs, CSRs, and regulatory submissions. Collaborate with cross-functional teams (clinical operations, regulatory, biometrics, safety, CMC, commercial) to drive program success. Engage with external experts, organize advisory boards, and contribute to scientific and medical communications. Identify and mitigate clinical and programmatic risks. Support portfolio development and evaluation of new clinical opportunities. Represent the company in regulatory and scientific forums as needed. QUALIFICATIONS:&nbsp; Education:&nbsp; Medical Degree (M.D.), OD, PhD, PharmD or equivalent Residency training in Ophthalmology with a preference for subspecialty training in retina Board certification a plus Retina fellowship training a plus Experience:&nbsp; 5+ years of clinical ophthalmology research in the biopharmaceutical industry Experience with Phase 3 retina clinical trials Experience with gene therapy a plus. Experience in other phases (Phase 1, 2, 4) of clinical research a plus. Experience with NDA/BLA/MAA submission a plus. Experience writing clinical research protocols and acting as a medical monitor&nbsp; Experience in data analysis, data interpretation, and medical writing Other Qualifications/Skills:&nbsp; Knowledge of ICH-GCP and FDA regulatory guidelines. Knowledge of international regulatory guidelines a plus. Effective written and verbal communication skills, including public speaking Travel: 15% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range:&nbsp;$275,000 - 325,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryPosition Summary We are seeking a highly organized and detail-oriented&nbsp;Talent Acquisition Coordinator to support our growing hiring needs. This temporary role will play a critical part in delivering a high-quality candidate experience, enabling efficient hiring processes, and supporting recruiters and hiring managers across the organization. This is a hybrid role with 2 days required onsite in our Emeryville, CA headquarters that combines coordination, recruiting operations, and early-stage talent assessment. The ideal candidate thrives in a fast-paced environment, demonstrates strong ownership, and can balance multiple priorities with accuracy and urgency. KEY RESPONSIBILITIES: &nbsp;Interview Scheduling &amp; Coordination (~40% of time) Coordinate and schedule interviews across multiple functions and time zones Partner closely with hiring managers, candidates, and interview panels to ensure seamless scheduling Manage complex calendars and prioritize scheduling speed and efficiency Ensure a high-quality, professional candidate experience at all touchpoints Prepare and distribute interview agendas and materials to interview teams Track and manage scheduling logistics within the ATS (Greenhouse) Proactively identify and resolve scheduling conflicts or delays Welcomes candidates onsite as needed &nbsp;TA Operations &amp; Temporary Workforce Management (~20% of time) Manage and maintain job requisitions and job offers in Greenhouse, ensuring accuracy and timely updates Support onboarding coordination for new hires as needed Oversee coordination and administration of temporary workers, including tracking assignments and extensions Partner with HR Operations to ensure accurate processing and tracking of contractor engagements Manage recruiting related POs &nbsp;Resume Review and Candidate Sourcing (~40% of time) Review resumes and applications to identify qualified candidates aligned with role requirements Conduct initial outreach to candidates and support pipeline generation through sourcing (e.g., LinkedIn, referrals) Partner to build and maintain strong candidate pipelines for key roles Ensure timely follow-up with candidates and maintain engagement throughout early stages Track candidate progress and maintain accurate records within Greenhouse As directed by the Talent Acquisition manager, perform initial candidate screenings to assess qualifications, experience, and alignment with the role Other job duties as assigned QUALIFICATIONS:&nbsp; Bachelors degree or some college preferred Required 2–3 years of experience in recruiting coordination or talent acquisition Required strong experience in Greenhouse and LinkedIn Recruiter Strong organizational skills and attention to detail Ability to manage multiple priorities in a fast-paced environment Excellent communication and interpersonal skills Proactive, solutions-oriented mindset Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $40-$50 per hour &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Talent Acquisition Coordinator (Temporary)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Competitive Intelligence Intern will support cross-functional teams by providing research, analysis, and insights that help guide strategic decision-making across therapeutic areas. This role offers hands-on exposure to competitive intelligence methodologies, the pharmaceutical lifecycle, and the broader biotech landscape. The intern will synthesize scientific, clinical, and commercial information to help identify market trends, competitive threats, and emerging opportunities. This position is ideal for a graduate-level student with strong scientific training and an interest in strategy, market analysis, or the business of biotechnology. Note: the position is part‑time, structured as a 10‑hour‑per‑week internship for an individual in ET time zone, or an individual who can be available during the weekday hours of 8-10am ET. The internship is expected to last 4-8 months, with exact timing to be finalized with the selected candidate. MAJOR DUTIES &amp; RESPONSIBILITIES: Track developments within select therapeutic areas, including emerging technologies, and investigative treatment approaches Conduct research on competitor pipelines, clinical trial activity, mechanisms of action for investigative products, regulatory updates, and market activities Monitor scientific publications, conference abstracts, and industry news to identify emerging trends or competitive signals Report key insights promptly through clear written summaries, presentations, or targeted updates Analyze scientific and clinical data to support development of disease landscape analyses Evaluate scientific literature, clinical trial data, data from Competitive Intelligence platforms, and product profiles to support competitive assessments Summarize complex scientific and clinical findings into clear, concise insights for internal stakeholders Translate scientific and competitive findings into insights that help inform strategic questions, including market positioning, differentiation, and potential risks Integrate market insights to shape opportunity assessments and product positioning Analyze and synthesize market data to assess potential commercial uptake, competitive positioning, and key dynamics shaping the commercial landscape for emerging therapies Identify commercial trends, demand signals, and adoption analogs to inform scenario planning, opportunity assessments, and competitive strategy recommendations Contribute to high-quality PowerPoint deliverables, reports, dashboards, and summaries for cross‑functional meetings related to business development initiatives Ensure accuracy, clarity, and scientific rigor across all Competitive Intelligence outputs Generate and maintain reoccurring and ad-hoc Competitive Intelligence reports QUALIFICATIONS:&nbsp; Education: Currently enrolled in, or recently graduated (within six months) from an M.S. or Ph.D. program in a relevant life science discipline Experience: Experience conducting literature reviews, analyzing scientific publications, and synthesizing scientific findings Exposure to, or coursework, in drug development, biotechnology, or healthcare markets&nbsp; High-level understanding of the pharmaceutical product lifecycle Knowledge in gene therapy and/or ophthalmology is preferred, but not required Other Qualifications/Skills:&nbsp; Demonstrated interest in competitive intelligence, commercial strategy, or healthcare consulting through coursework, organizational involvement, or related experience Strong understanding of biological mechanisms underlying disease Excellent communication skills, including scientific writing, analytical synthesis, and presentation development Advanced proficiency in Microsoft Office, including Excel, PowerPoint, Word, and Outlook Ability to conduct qualitative and quantitative research using relevant databases and analytical tools Project-oriented mindset with the ability to take full ownership of assigned topics and deliverables Strong analytical and problem-solving skills Growth mindset with the flexibility to take on new assignments in a dynamic, fast-paced environment Travel: 0% (Full-Time Remote) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Hourly Rate: $25/hourly Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Intern

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; We are seeking a Clinical Records Associate for our TMF Operations Department Reporting to the Associate Director of TMF Operations. This position is responsible for collecting, reviewing, maintaining, and archiving essential documents for the Trial Master File (TMF) in accordance with Good Clinical Practice (GCP), E6 ICH Guidelines and other regulatory guidance documents, relevant regulations (e.g., 21 CFR Parts 312 and 314, EMA Clinical Trials Directives), and 4DMT’s Standard Operating Procedures (SOPs) as appropriate.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Responsible for TMF Oversight development and execution, ensuring all clinical documentation is being collected, handled, transferred, and stored via secured and authorized methods, ensuring compliance with global and local standards, requirements, and guidelines. Manage TMF performance objectives for end-to-end processes ensuring quality, timeliness, and completeness throughout the lifecycle of the study by overseeing and/or ensuring ongoing reviews to confirm documents are collected and maintained per ICH guidelines and global regulatory requirements. Perform the role of the Clinical Records Associate for all Clinical Trials at 4DMT throughout the TMF lifecycle, from study start-up and document collection to oversight and archiving. Participate in Quality Assurance audits and/or regulatory authority inspections. Support Study Teams to proactively maintain current Expected Documents List (EDL) counts and to file essential documents promptly according to TMF Plans and Indexes, including adjustments due to unanticipated events during trial conduct. Identify study-specific TMF compliance gaps (missing or low-quality documents) and track resolutions to closure quickly. Manage the performance of external vendors responsible for TMF-related deliverables. Escalate issues and/or process improvement suggestions and collaborate cross-functionally to define and implement solutions, Veeva Vault system changes, or corrective and preventative actions. Contribute to the development and improvement of department-level and cross-functional Standard Operating Procedures (SOPs), processes, systems, tools. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. QUALIFICATIONS:&nbsp; Education:&nbsp; A./B.S. degree (preferably in a scientific or healthcare-related field) preferred High school diploma required Experience:&nbsp; A B.S. with 2+ years relevant experience including extensive experience with Veeva Vault TMF or a H.S. diploma with 6+ years relevant experience. 2+ years of TMF QC Review and knowledge of clinical documentation content required. Experience working with cross-functional teams to improve TMF compliance (quality, completeness, and timeliness) Other Qualifications/Skills: Knowledge of and ability to apply applicable regulations and guidelines (e.g., ICH/GCP/Good Documentation Practice). Expert knowledge of cross-functional TMF content requirements throughout the trial. Proficiency in Microsoft Office Suite for collaboration with team members. Especially proficient in Excel for tracking, sorting, filtering, and managing large sets of metadata. Excellent communication skills (written and verbal). Interpersonal skills, including conflict resolution in a fast-paced, deadline-driven environment. Strong attention to detail and organizational skills. Ability and drive to follow through on detailed tasks to closure. Analytical skills to evaluate and interpret complex situations/problems using multiple sources of information. Development and maintenance of TMF Plans. Demonstrated understanding of the DIA Reference Model filing structure and contents. Preferred Skills and Experience: Managing CROs performing TMF activities. Creating and using enterprise system reports to calculate metrics and troubleshoot issues. All aspects of clinical trial conduct (startup through close-out and TMF Archiving). Experience with additional Veeva products such as CTMS or Vault RIM. Experience using collaborative tools like SharePoint and Microsoft Teams and Channels. Travel: % Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range:&nbsp;$92,000 - $116,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Clinical Records Associate

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY We are seeking a TMF Quality &amp; Oversight Specialist, reporting to the Senior Manager, Clinical Records. This contractor will support the review, quality oversight, and maintenance of Trial Master File (TMF) documentation in accordance with GCP, ICH E6, regulatory requirements, and 4DMT SOPs. In addition to QC review, the role will help develop and execute Oversight Review processes in Veeva Vault eTMF and support system change requests by representing the Business Process Owner (BPO) perspective. This work is critical to strengthening TMF oversight and ensuring inspection readiness. MAJOR DUTIES &amp; RESPONSIBILITIES: QC Review &amp; Documentation Support Perform detailed QC reviews of TMF documents to verify metadata accuracy, confirm proper filing, and ensure compliance with ICH GCP, regulatory standards, and internal SOPs. Identify documentation gaps, inconsistencies, or quality issues and collaborate with TMF Operations team members to resolve them promptly. Support ongoing TMF review activities throughout the study lifecycle to help ensure quality, timeliness, and completeness. Assist with audit and inspection preparation by supporting the TMF team in documentation readiness activities. Oversight Review Process Development Contribute to the continuous improvement of Oversight Review processes within Veeva Vault eTMF, including workflows, dashboards, and metrics. Support the development of review standards, success metrics, and monitoring tools that provide visibility into TMF quality, completeness, and inspection readiness. Support TMF Operations leadership in identifying process improvement opportunities and contributing to the development of new tools, workflows, and best practices. Business Process Owner (BPO) Support for System Enhancements Assist in preparing business requirements, documenting user needs, and participating in validation testing and user acceptance activities from the BPO perspective. Provide input into change control documentation and support cross-functional collaboration with IT, Quality, and Managed Services teams during configuration updates. Help develop training materials, reference guides, and user communications to support adoption of new functionality or process changes. QUALIFICATIONS:&nbsp; REQUIRED EXPERIENCE: Minimum 5 years of relevant experience in TMF Operations, including extensive hands-on work with Veeva Vault eTMF. At least 2 years performing TMF QC review, applying knowledge of clinical documentation content and metadata standards. Experience supporting TMF planning, implementation, and configuration activities, including review of TMF Plans and participation in system setup or enhancements. Demonstrated understanding of the CDISC Reference Model, TMF structure, ICH/GCP, Good Documentation Practice, and regulatory documentation requirements. PREFERRED EXPERIENCE: Experience partnering with or overseeing CROs performing TMF activities. Hands-on involvement in system reporting, dashboard development, or configuration testing within Veeva Vault. Exposure to multiple phases of clinical trial conduct (startup through close-out and TMF archiving). Familiarity with additional Veeva products such as CTMS or Vault RIM. REQUIRED SKILLS: Proficiency in Microsoft Office Suite for collaboration with team members. Especially proficient in Excel for tracking, sorting, filtering, and managing large sets of metadata. Interpersonal skills, including conflict resolution in a fast-paced, deadline-driven environment. Strong attention to detail and organizational skills including the ability and drive to follow through on detailed tasks to closure. Analytical skills to evaluate and interpret complex situations/problems using multiple sources of information. Travel: 0% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Hourly Rate: $60.00 &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

TMF Quality Specialist

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: The Senior Manager, Data Management leads execution of end‑to‑end clinical data management activities for assigned studies and provides operational oversight to internal staff and external vendors. This role serves as a key member of cross‑functional study teams, contributing to planning, execution, and delivery of high‑quality clinical trial data across all phases. The Senior Manager possesses robust working knowledge of clinical data management processes and independently executes most tasks while also providing guidance to other Data Managers and vendor partners. Data management is one of the essential functions of the Clinical Development organization at 4DMT. Together with the other two functions within the Data Science group, Biostatistics, and Statistical Programming, we provide critical support for the company’s clinical development programs in gene therapies for retina diseases and other therapeutic areas. MAJOR DUTIES &amp; RESPONSIBILITIES: Manage end‑to‑end Data Management activities for one or more clinical studies with moderate guidance from line manager. Oversee daily study‑level data management operations, ensuring compliance to timelines, quality standards, and SOPs. Support vendor oversight activities, including reviewing timelines, deliverables, and quality metrics. Contribute to risk identification and mitigation strategies for data‑related issues. Review study protocols to ensure appropriate data capture elements and eCRF design. Support the development of eCRF specifications and contribute to review of data requirements. Assist in coordinating EDC system design, testing, and UAT, ensuring adherence to company standards. Contribute and/or author Data Management Plans, Data Transfer Plans, and other study‑related documents Support review of clinical monitoring plans, SAPs, and vendor specifications. Monitor data quality and cleaning activities, including management of data listings and reconciliation efforts. Partner with CROs and external vendors to ensure timely and high‑quality data deliverables. Participate in study team meetings, providing updates on Data Management metrics and timelines. Escalate issues appropriately to line manager, data management leadership or other functional leads. Oversee reconciliation activities (e.g., header data, SAE reconciliation) performed by CROs. Support database upgrades and migrations, including contribution to UAT. Participate in database snapshot, lock, and freeze activities. Provide day‑to‑day guidance and mentorship to Data Managers. Deliver training to internal and external team members on EDC systems or eCRF completion guidelines as needed. Maintain Data Management documentation and eTMF files. Other duties assigned: nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. QUALIFICATIONS: Education: B.A./B.S. degree or higher (life-science-related fields preferred) or equivalent experience. Experience: 7+ years of data management experience in the biotech/pharmaceutical industry or clinical data management service providers of which at least three (3+) years in a lead study data manager role. Experience with Phase 1-3 clinical trials required: retina diseases and/or gene therapies experience a plus. Demonstrated experience in vendor oversight and cross‑functional team leadership. Experience in vendor management and performance assessments In-depth knowledge and experience with CDISC data standards and models. Other Qualifications/Skills: Proficient in using clinical data management systems (e.g., Medidata Rave) and the data flow, including those from external sources (IRT, safety, central/specialty labs, reading centers, PROs, etc.) Proficiency in data management process and knowledge of Good Clinical Data Management Practices (GCDMP) in global clinical trials Knowledge of ICH GCP and other applicable regulatory rules and guidelines. Knowledge of the clinical development process Proficient with MS Office (Worl, Excel, PowerPoint, etc.) Strong communication and interpersonal skills (written and verbal) Collaborative mindset with ability to work effectively. High attention to detail with excellent organizational and time‑management capabilities. Ability to manage multiple projects in a fast-paced environment Proven conceptual, analytical and strategic thinking Excellent attention to details Travel: 0-10%, based on study needs. Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $178,000 - 205,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp;&nbsp; 4DMT seeks a motivated and experienced Associate Clinical Trial Manager to support the Company's clinical trial activities.&nbsp; This position will be responsible for supporting the day-to-day operations of one Phase 3 clinical trials including trial conduct and close-out activities.&nbsp; This role requires strong, professional written and verbal communication skills, good organization and attention to detail, and the ability to consistently provide high quality work while managing competing priorities and maintaining tight timelines.&nbsp; This person must be interested in working in a fast-paced, team-oriented environment and be willing to work beyond their job scope to achieve department and company objectives. MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp;&nbsp; Coordinate tracking of a clinical trial(s) under the oversight of the Clinical Trial Management Collect, track and conduct initial review for completeness of site regulatory documents and/or TMF filing Organize, maintain and participate in audits and close out of the Trial Master File (TMF/eTMF) Maintain multiple tracking spreadsheets following the progress of assigned clinical trials, such as study subject tracking, essential document tracking Track and coordinate CRO and third-party vendor activities, including vendor provided meeting minutes, study updates and trackers Perform first pass review of all site and vendor invoices including tracking and generation of monthly/quarterly accruals for finance Assist and/or contribute to the creation and maintenance of study materials for clinical studies, including but not limited to site and CRA training material, regulatory document templates, study binders, study plans/manuals, study communications and presentations Communicate directly with sites handling triages, Contract Research Organizations (CROs) and CRA/monitors to obtain updated information, essential documents, etc. to assist with study conduct, and/or close-out activities Assist with tracking of clinical trial progress including status update reports, as requested Assist with the organization, management and conduct of internal team meetings, investigator meetings and other trial-specific meetings, including minute taking and action item log tracking Utilize EDC/CTMS systems to acquire and synthesize data, metrics, or reports as necessary (enrollment data, randomizations, data cleaning, SAEs, etc.) for CTM, specific meetings or management updates May assist CTM in tracking and follow-up of monitoring visit reports and unresolved issues Other duties as may be assigned QUALIFICATIONS:&nbsp;&nbsp; Education: A./B.S. degree required Experience: At least 5 years of work experience supporting clinical trials Other Qualifications/Skills: Basic knowledge of clinical trial operations, ICH GCP Guidelines and other applicable regulatory requirements Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, SharePoint and Outlook Ability to prioritize and manage competing priorities Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners Travel: 20% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $62.00-72.00 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Associate Clinical Trial Manager (Temporary)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; This role is in the Biomarkers &amp; Immunology department and supports immunogenicity risk assessments, biomarker measurements, and clinical pharmacology deliverables by developing novel bioanalytical methods and providing expert analysis and interpretation of key bioanalytical datasets. Bioanalytical methods are rigorously qualified and validated to generate high-quality data for internal stakeholders. Working closely with cross-functional teams (e.g., Early-Stage Product Development, Project Management, Clinical Operations, and Clinical Development), these deliverables inform key program decisions. This position reports to the Director, Biomarkers &amp; Immunology, and supports 4DMT’s mission and portfolio of targeted genetic medicines. On-site work is required for laboratory activities; however, a flexible hybrid schedule may be accommodated for data analysis and remote oversight of partner organizations. MAJOR DUTIES &amp; RESPONSIBILITIES: Provide scientific and technical leadership in the development and qualification of innovative bioanalytical assays, including ligand-binding assays, anti-drug antibody (ADA) assays, cell-based assays, and molecular assays to evaluate immunogenicity, PK/PD, and biomarkers for preclinical and clinical use across multiple therapeutic areas (e.g., ophthalmology, pulmonology, CNS). Lead assay lifecycle activities (method development, qualification, validation, and implementation), including defining fit-for-purpose performance criteria, identifying risks, and driving timely resolution of technical issues. Oversee GxP workflows and apply relevant regulatory guidance for early-stage and late-stage assay development, validation, and implementation. Ensure data integrity and inspection readiness as applicable. Independently design and execute experiments; analyze and interpret data; and communicate conclusions, limitations, and recommendations to management and study teams to enable decisions. Contribute to the design and interpretation of in vivo and in vitro studies to support assay development and biomarker strategy, including selection of appropriate readouts and defining decision criteria. Assess and select contract research organizations (CROs), lead technology transfer, and manage external assay method development, qualification, and GxP validation, including vendor performance, issue escalation, and corrective actions. Partner with Clinical Development and Clinical Operations to define bioanalytical strategy (including sampling strategy and assay performance characteristics) that supports key clinical pharmacology questions (PK/PD, exposure–response, dose selection). Review and interpret bioanalytical datasets for quality, trends, and consistency; summarize findings for study teams and contribute to data summaries. Author and/or review sections of clinical and regulatory documents (e.g., protocols, sample handling instructions, bioanalytical plans, study reports, Investigator’s Brochure, IND/CTA content) related to PK/PD, immunogenicity, and bioanalytical methods, ensuring scientific accuracy and consistency of key messages. Mentor junior staff by providing technical guidance, coaching on experimental design and data interpretation, and reviewing draft deliverables. Maintain awareness of relevant scientific literature and emerging technologies; recommend and pilot improvements that increase assay robustness, throughput, or interpretability. Write study reports and manuscripts and present results at scientific meetings. Maintain compliance with company Environmental Health and Safety policies, procedures, and practices. Contribute to a culture of continuous improvement and innovation; encourage team members to expand technical skills and deepen gene therapy expertise. QUALIFICATIONS: Education: Degree in immunology, bioengineering, molecular biology, cell biology, pharmacology, biochemistry, or a related field. PhD with 3+ years of industry or relevant academic experience; Master’s degree with 5+ years; Bachelor’s degree with 7+ years. Experience: Bioanalytical and/or biomarker assay development experience is strongly preferred. Experience leading anti-drug antibody assay development and qualification and contributing to validation in a regulated environment (e.g., GxP, as applicable), including defining fit-for-purpose criteria, ensuring data integrity, and troubleshooting complex technical issues. Experience with PCR, qPCR, and droplet digital PCR; RNA-seq; and tissue culture of primary cells and established cell lines. Familiarity with ligand binding assays and LC-MS is a plus. Late-stage clinical trial experience, biologics license application experience, and CRO oversight (including deliverable review, issue escalation, and corrective actions) are a plus. Working knowledge of clinical pharmacology concepts (PK/PD, exposure metrics, dose selection, exposure–response) and experience translating study objectives into bioanalytical strategy (e.g., sampling strategy, assay performance characteristics), data generation plans, and interpretation for biologics and/or gene therapies is preferred. Other Qualifications/Skills: Competence in standard microplate reader use (e.g., SoftMax software), Meso Scale Discovery platform instruments, PCR primer/probe design, and protein labeling, detection, and purification techniques. Demonstrated ability to independently design, develop, and execute new assay methods and to provide technical leadership through critical review of experimental plans, data quality, and conclusions. Strong attention to detail with the ability to rigorously analyze and interpret data, ensure data integrity and inspection-ready documentation as applicable. Demonstrated ability to influence cross-functional decisions by identifying bioanalytical risks, proposing mitigation plans, and aligning stakeholders on fit-for-purpose approaches. Ability to work cooperatively in a team-based environment, supportive of multiple viewpoints and approaches, and able to provide constructive scientific feedback. Strong written and verbal communication skills, with demonstrated ability to frame complex data into clear recommendations for diverse audiences (e.g., study teams, functional leaders, and external partners). Ability to translate assay performance (e.g., sensitivity, selectivity, drug tolerance, stability, dilutional linearity) into fit-for-purpose guidance for clinical and nonclinical analyses. Familiarity with data workflows and common analysis/reporting tools used to summarize and trend bioanalytical results (e.g., Excel, JMP, GraphPad Prism; Python and/or R is a plus). Travel: &lt;5% Physical Requirements and Working Conditions: Ability to lift up to 20 lbs; bend and twist; and wear personal protective equipment (PPE) such as a lab coat, goggles/glasses, and nitrile gloves. Base salary compensation range:$164,000 -182,000 &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Scientist

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp;The Clinical Trial Manager will support the Company's clinical trial activities. This position reports to the Director of Clinical Operations. This will be responsible for management of the day to day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close out activities.&nbsp; This is a 6 month contract remote opportunity. &nbsp;&nbsp;MAJOR DUTIES &amp;&nbsp;RESPONSIBILITIES:&nbsp; Trial Management:&nbsp;&nbsp; Serve as the primary contact for managing protocol execution, including oversight of the CRO, other study service providers, and consultants that are involved in a clinical trial&nbsp; Lead cross-functional study execution team in support of study deliverables&nbsp; Support establishment of study milestones and ensure&nbsp;accurate&nbsp;tracking and reporting of study metrics and timelines to leadership&nbsp; Ensure clinical trials are managed and executed&nbsp;in accordance with&nbsp;ICH GCP, regulations, the protocol, and company-specific SOPs&nbsp; Assist&nbsp;in preparation and review of clinical trial documentation such&nbsp;as;&nbsp;protocol, informed consent, Investigator Brochure, Clinical Monitoring Plan, Project Plan, Case Report Forms, Statistical Analysis Plan, Clinical Study Reports, and other study level documents&nbsp; Ensure that the Trial Master File (TMF) is set up and&nbsp;maintained&nbsp;appropriately throughout the trial, including periodic reviews&nbsp; Participate and coordinate resolution of audit finding and&nbsp;ensures&nbsp;audit-ready condition of clinical trial documentation including central clinical files&nbsp; Participates in service provider selection process as a part of outsourcing activities&nbsp; Proactively&nbsp;identifies, with the support and guidance from Senior Clinical Operations staff, and supports development of plans and resolution of project issues and&nbsp;participates&nbsp;in process improvement initiatives as&nbsp;required&nbsp; Supports assessing operational feasibility, recommending study execution plan and site selection under the&nbsp;Director of Clinical Operations&nbsp; Responsible for the selection and study specific training of CRO study staff, monitors,&nbsp;investigational&nbsp;sites, and service providers&nbsp; In conjunction with&nbsp;legal group, facilitate&nbsp; the development&nbsp; of clinical&nbsp; trial agreements and other relevant documents&nbsp; Manage clinical trial budgets, providing ongoing financial reporting and projections&nbsp; Negotiate and&nbsp;finalize&nbsp;site contracts and budgets&nbsp; Perform and manage data review process on an ongoing basis&nbsp; Perform site visits including site qualification, initiation,&nbsp;monitoring&nbsp;and close-out visits, as needed&nbsp; Oversee outsourced monitoring by&nbsp;reviewing,&nbsp;monitoring reports to ensure quality and resolution of site-related issues&nbsp; Ensures tracking and review of protocol deviations and assesses impact on study data&nbsp; Develops and manages study budget and&nbsp;maintain&nbsp;within financial goals; Reviews and approves clinical invoices against approved budget&nbsp; Provides oversight for forecasting of clinical supplies, including study drug and supplies&nbsp; Department Management:&nbsp;&nbsp; May manage and/or oversee work of junior Clinical Operations staff&nbsp; May support development and review of Clinical SOPs and other department initiatives&nbsp; Travel as needed to sites, conferences, industry meetings&nbsp; Other duties as may be assigned&nbsp; &nbsp;QUALIFICATIONS:&nbsp; Education:&nbsp; B.A./B.S.&nbsp;degree&nbsp; &nbsp;Experience:&nbsp; 6+ years of clinical research experience within the Biotech or similar industry, with at&nbsp;least&nbsp;2 years directly supporting clinical trial management&nbsp; &nbsp;Other Qualifications/Skills:&nbsp; (non-technical and technical skills)&nbsp; Knowledge of GCP, ICH guidelines and regulatory requirements for clinical trial management; Strong clinical study management skills&nbsp; Understanding of, and experience with, regulatory framework applicable to interactions with HCPs, payers,&nbsp;advocacy&nbsp;and other business partners&nbsp; Proven clinical operational skills to direct protocol execution to ensure timeline, budget and quality metrics are met&nbsp; Excellent communication skills to effectively&nbsp;disseminate&nbsp;information to project team and outside parties&nbsp; Experience reviewing trial plans including developing creative strategies for site monitoring, risk mitigation, trial budgets, site&nbsp;selection, and clinical supplies management&nbsp; Clinical research knowledge and cross-functional understanding of clinical trial&nbsp;methodology&nbsp; Excellent organizational, conflict resolution,&nbsp;prioritization&nbsp;and negotiation skills &nbsp; Proven ability in creative problem-solving and exercising sound judgment&nbsp; Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners&nbsp; Ability to handle a high volume of&nbsp;highly complex&nbsp;tasks within a given timeline&nbsp; Ability to develop Therapeutic Areas knowledge and&nbsp;expertise&nbsp;through internal training and external conference attendance&nbsp; Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, and Outlook&nbsp; Working knowledge of MS Project for development and update of clinical study timelines&nbsp; &nbsp;Travel: 5%&nbsp; Physical Requirements and Working Conditions:&nbsp; Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas&nbsp;by means of&nbsp;the spoken word.&nbsp; Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Working Conditions - The worker is not&nbsp;substantially exposed&nbsp;to adverse environmental conditions (as in typical office or administrative work).&nbsp; HR&nbsp;ONLY: Hourly Compensation Range: $84.00 - 94.00 Please&nbsp;note,&nbsp;the compensation range and actual&nbsp;rate&nbsp;offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Clinical Trial Manager (Contract)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: The Senior Recruiter is responsible for driving full-cycle recruitment across 4DMT, partnering closely with hiring managers and Associate Director, Talent Acquisition to deliver high-quality talent aligned with the company’s growth objectives. This role supports execution of the Talent Acquisition strategy, manages external and ensures a consistent, efficient, and high-caliber hiring process. The Senior Recruiter will play a critical role in sourcing, engaging, and closing top talent in a competitive biotech market. RESPONSIBILITIES: Manage full-cycle recruitment for assigned roles, including sourcing, screening, interviewing, and offer negotiation Partner with hiring managers to understand hiring needs, define role requirements, and develop candidate profiles Proactively source and engage candidates using a variety of channels, including LinkedIn Recruiter and networking Draft and refine job descriptions in partnership with HR and Total Rewards, ensuring alignment with leveling and compensation frameworks Coordinate and drive interview processes, including scheduling, debrief facilitation, and delivery of structured feedback Support offer development and negotiation in alignment with company compensation philosophy Partner with external search firms and staffing agencies as needed; help ensure quality and cost-effectiveness of vendor support Track and maintain recruiting data, ensuring accuracy in systems such as Greenhouse and contributing to hiring metrics and reporting Support execution of hiring plans in alignment with approved headcount and business priorities Identify opportunities to improve recruiting processes, tools, and candidate experience Stay informed on industry trends and talent market dynamics within biotech/pharma Promote inclusive hiring practices and support efforts to mitigate bias in the recruiting process Participate in special projects and broader Talent Acquisition or HR initiatives as needed Other duties as assigned; this role offers opportunities to contribute to broader HR and organizational initiatives QUALIFICATIONS: Education: Bachelor’s degree or equivalent HR Certification is a plus Experience: 8+ years of full-cycle recruiting experience in biotech or pharmaceutical industry, as part of the internal talent acquisition team Strong experience hiring of clinical roles; hiring of commercial roles is a plus Proven ability to manage multiple requisitions across technical and business functions Strong proficiency with recruiting systems and tools, including Greenhouse and LinkedIn Recruiter Experience partnering with external search firms and staffing agencies &nbsp; Skills: Strong execution focus with the ability to manage multiple priorities in a fast-paced environment Solid understanding of recruiting best practices and applicable employment laws Ability to build effective partnerships with hiring managers and cross-functional stakeholders Strong judgment and ability to handle confidential and sensitive information Excellent communication, organization, and follow-through Strong interpersonal skills and ability to influence without authority Hourly compensation range: $69.00 - $95.00 Please note, the hourly compensation range offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Recruiter (Contract)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Director of Clinical Quality Assurance (CQA) will be responsible for Quality Assurance oversight of multiple, global, 4DMT sponsored clinical trials, ensuring trials are executed in compliance with all applicable international regulatory requirements for Good Clinical Practice (GCP). This position reports to the Senior Director, GCP Compliance and Quality Systems and contributes to the development, implementation, and successful execution of the CQA mission, objectives, and strategic plan. MAJOR DUTIES &amp; RESPONSIBILITIES: Provide Quality oversight for multiple 4DMT Clinical Studies, including the following study-specific activities: Develop and implement Clinical Study Quality Plans for specific 4DMT clinical studies, focused on ensuring subject safety/rights, study data integrity, and GCP compliance. Provide guidance and support to clinical study teams, including via attendance at Study team meetings and via investigation and management of Clinical Study Quality Events Ensure principles of Risk Management are applied to the Clinical Study per ICH E6 Identify, communicate, and escalate significant incidents of GCP non-compliance and follow to resolution, acting at all times with an appropriate sense of urgency Plan, perform, and/or oversee GCP Compliance audits of high-risk clinical vendors/sites, including clinical investigator sites Ensure audit findings are communicated to audit stakeholders and collaborate with auditees and vendors to track, review, approve, and assess the adequacy of CAPAs Perform Clinical Document reviews, ensuring the quality, accuracy and completeness of various documents, including as applicable Clinical Protocols, IBs, DSURs, Module 2.6 Tabulated and Written Summaries, and Integrated Summaries Support investigation and management of specific Clinical Study Quality Events as assigned: Monitor, track, and facilitate the completion of formal corrective and preventive actions (CAPAs) to address identified Clinical Study Quality Events, including potential serious breaches of GCP. Support a quality-focused work environment in Clinical that fosters learning, respect, open communication, collaboration, integration, and teamwork: Work with Clinical stakeholders to develop GCP compliance training materials and conduct training Partner with Clinical team to review, update and maintain related SOPs, identify the need for new SOPs, and support the review of new SOPs as needed Work with Clinical stakeholders to support Training, Development, and Implementation of 4DMT Clinical Study Risk Management Process/Tools to ensure principles of Risk Management are applied to 4DMT Clinical Studies per ICH E6 Drive the development and continuous improvement of the Clinical Quality Management System through the development / refinement of Clinical QA processes Support preparedness / readiness / management of BIMO inspections: Develop/support GCP inspectional readiness plans and lead inspectional readiness activities Host and/or assist with management of GCP-related inspections Partner with GMP Quality and Clinical Operations teams to facilitate the investigation of clinical supply quality issues such as temperature excursions, product complaints and deviations reported from clinical sites. QUALIFICATIONS:&nbsp; Education: S./B.A. degree in a science or related life science field or equivalent; advanced scientific degree preferred. Experience: 10+ years of experience or advanced degree with 7+ years of experience within a regulated environment such as Regulatory, Quality, Pharmacovigilance or Clinical Development / Operations within the Biotech or similar Industry Proven experience with GCP Quality Management Systems, quality support, and quality oversight of global clinical trials Minimum of 4 years of significant experience in clinical quality assurance, including experience performing/supporting GCP audits and overseeing global clinical trials, including in APAC. Extensive practical experience and understanding of clinical quality assurance as applied throughout the clinical development life-cycle (Optional) 5+ years of management experience or other specific work experience Other Qualifications/Skills: In-depth understanding of GCP requirements for investigational products Excellent communication skills, both oral and written Excellent interpersonal skills, collaborative approach essential Comfortable in a fast-paced small company environment with minimal direction and able to adjust to workload based upon changing priorities Travel: %5 Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range:&nbsp;$205,000 - $235,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Clinical Quality Assurance (CQA)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY 4DMT seeks a motivated and detail-oriented In-House Clinical Research Associate (IHCRA) to support the Company’s clinical trial activities. This position reports to the Associate Director, Clinical Operations, and will support the day-to-day execution of a Phase 3 clinical trial, including study start-up, conduct, and close-out activities. The IHCRA will serve as a key liaison between 4DMT, clinical sites, and CRO partners, with a focus on site support, monitoring oversight, regulatory compliance, and data quality. This role requires strong written and verbal communication skills, excellent organizational skills, and the ability to manage competing priorities while delivering high-quality work in a fast-paced, team-oriented environment. MAJOR DUTIES &amp; RESPONSIBILITIES: Clinical Trial Operations &amp; Site Support Support study execution across start-up, conduct, and close-out phases Serve as a primary point of contact for assigned clinical sites and CRO field CRAs/monitors Communicate directly with sites and CRO partners to obtain updates, resolve issues, and support study timelines Support site initiation, ongoing site management, and site close-out activities Assist with identification, documentation, tracking, and follow-up of site issues &nbsp;Monitoring Oversight Support oversight of CRO monitoring activities Review monitoring visit reports and follow up on action items and unresolved findings Track monitoring deliverables and escalate issues to the Associate Director, Clinical Operations as appropriate Support inspection readiness and audit activities &nbsp;Tracking &amp; Study Oversight Maintain accurate tracking tools for assigned studies, including: Site start up and activation status Subject enrollment and visit status Essential document collection and TMF status Vendor reconciliation Assist with preparation of study status reports and metrics &nbsp;Regulatory Documentation &amp; TMF Management Collect, review, and track site regulatory documents for completeness, accuracy, and compliance with applicable SOPs and regulatory requirements Ensure timely filing of documents in the TMF/eTMF in accordance with TMF plans Perform TMF quality control activities and support TMF audits and study close out &nbsp;Study Communications &amp; Meetings Support organization and coordination of internal team meetings, investigator meetings, and other study related meetings Prepare meeting materials, take meeting minutes, and maintain action item logs Support communication of study updates to internal stakeholders &nbsp;Additional Responsibilities Support ad hoc Clinical Operations projects as assigned Willingness to travel as trial needs demand (&lt;5% anticipated) Other duties as assigned, nothing in this position description restricts management’s right to assign or reassign duties and responsibilities to this position at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; A. or B.S. degree required Experience:&nbsp; Minimum of 1-2 years of experience supporting clinical trials in a sponsor or CRO environment Experience supporting Phase 3 clinical trials preferred Ophthalmology Preferred Other Qualifications/Skills:&nbsp; Working knowledge of clinical trial operations and ICH GCP guidelines Experience with TMF/eTMF systems (Veeva Vault preferred) Proficient in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) Strong organizational skills and attention to detail Ability to manage multiple priorities and meet deadlines Strong interpersonal skills and ability to collaborate effectively with cross functional teams and external partners Travel: Willingness to travel as business needs demand (&lt;5% anticipated) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Compensation range: $38.00 TO 52.00&nbsp; /HOURLY Please note, the compensation range and actual rate offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Clinical Research Associate (Contract)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY 4DMT seeks a motivated and detail-oriented In-House Clinical Research Associate (IHCRA) to support the Company’s clinical trial activities. This position reports to the Associate Director, Clinical Operations, and will support the day-to-day execution of a Phase 3 clinical trial, including study start-up, conduct, and close-out activities. The IHCRA will serve as a key liaison between 4DMT, clinical sites, and CRO partners, with a focus on site support, monitoring oversight, regulatory compliance, and data quality. This role requires strong written and verbal communication skills, excellent organizational skills, and the ability to manage competing priorities while delivering high-quality work in a fast-paced, team-oriented environment. MAJOR DUTIES &amp; RESPONSIBILITIES: Clinical Trial Operations &amp; Site Support Support study execution across start-up, conduct, and close-out phases Serve as a primary point of contact for assigned clinical sites and CRO field CRAs/monitors Communicate directly with sites and CRO partners to obtain updates, resolve issues, and support study timelines Support site initiation, ongoing site management, and site close-out activities Assist with identification, documentation, tracking, and follow-up of site issues &nbsp;Monitoring Oversight Support oversight of CRO monitoring activities Review monitoring visit reports and follow up on action items and unresolved findings Track monitoring deliverables and escalate issues to the Associate Director, Clinical Operations as appropriate Support inspection readiness and audit activities &nbsp;Tracking &amp; Study Oversight Maintain accurate tracking tools for assigned studies, including: Site start up and activation status Subject enrollment and visit status Essential document collection and TMF status Vendor reconciliation Assist with preparation of study status reports and metrics &nbsp;Regulatory Documentation &amp; TMF Management Collect, review, and track site regulatory documents for completeness, accuracy, and compliance with applicable SOPs and regulatory requirements Ensure timely filing of documents in the TMF/eTMF in accordance with TMF plans Perform TMF quality control activities and support TMF audits and study close out &nbsp;Study Communications &amp; Meetings Support organization and coordination of internal team meetings, investigator meetings, and other study related meetings Prepare meeting materials, take meeting minutes, and maintain action item logs Support communication of study updates to internal stakeholders &nbsp;Additional Responsibilities Support ad hoc Clinical Operations projects as assigned Willingness to travel as trial needs demand (&lt;5% anticipated) Other duties as assigned, nothing in this position description restricts management’s right to assign or reassign duties and responsibilities to this position at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; A. or B.S. degree required Experience:&nbsp; Minimum of 1-2 years of experience supporting clinical trials in a sponsor or CRO environment Experience supporting Phase 3 clinical trials preferred Ophthalmology Preferred Other Qualifications/Skills:&nbsp; Working knowledge of clinical trial operations and ICH GCP guidelines Experience with TMF/eTMF systems (Veeva Vault preferred) Proficient in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) Strong organizational skills and attention to detail Ability to manage multiple priorities and meet deadlines Strong interpersonal skills and ability to collaborate effectively with cross functional teams and external partners Travel: Willingness to travel as business needs demand (&lt;5% anticipated) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Compensation range: $38.00 TO 52.00&nbsp; /HOURLY Please note, the compensation range and actual rate offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY 4DMT seeks a motivated and detail-oriented In-House Unmasked Clinical Research Associate (uIHCRA) to support the Company’s clinical trial activities. This position reports to the Unmasked Clinical Trial Manager, Clinical Operations, and will support the day-to-day execution of a Phase 3 clinical trial, including study start-up, conduct, and close-out activities.&nbsp; Role requires extensive experience in unmasked clinical settings.&nbsp; The uIHCRA will serve as a key liaison between 4DMT, clinical sites, and CRO partners, with a focus on site support, monitoring oversight, regulatory compliance, and data quality. This role requires strong written and verbal communication skills, excellent organizational skills, and the ability to manage competing priorities while delivering high-quality work in a fast-paced, team-oriented environment. MAJOR DUTIES &amp; RESPONSIBILITIES: Clinical Trial Operations &amp; Site Support Support study execution across start-up, conduct, and close-out phases Serve as a primary unmasked sponsor point of contact for unmasked clinical site staff in collaboration with CRO field unmasked CRAs/monitors Communicate directly with unmasked site staff and unmasked CRO partners to obtain updates, resolve issues, and support study timelines Support site initiation, ongoing site management, and site close-out activities Assist with identification, documentation, tracking, and follow-up of site issues Monitoring Oversight Support oversight of unmasked CRO monitoring activities Review unmasked monitoring visit reports and follow up on action items and unresolved findings Track monitoring deliverables and escalate issues to the Unmasked Clinical Trial Manager, Clinical Operations as appropriate Support inspection readiness and audit activities Tracking &amp; Study Oversight Maintain accurate tracking tools for assigned studies, including: Site start up and activation status Initial IP supply and Ancillary supply Site visit activities IP Shipment status and delivery Assist with preparation of study status reports and metrics Regulatory Documentation &amp; TMF Management Collect, review, and track site applicable SOPs Ensure timely filing of unmasked documents in the TMF/eTMF in accordance with TMF plans Perform TMF quality control activities and support TMF audits and study close out Support the review of Quality Incidents and follow up activities Study Communications &amp; Meetings Support organization and coordination of internal team meetings, and other study related meetings Prepare meeting materials, take meeting minutes, and maintain action item logs Support communication of study updates to internal stakeholders Additional Responsibilities Support ad hoc Clinical Operations projects as assigned Willingness to travel as trial needs demand (&lt;15% anticipated) Other duties as assigned, nothing in this position description restricts management’s right to assign or reassign duties and responsibilities to this position at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; A. or B.S. degree required Experience:&nbsp; Minimum of 1-2 years of experience supporting clinical trials in a sponsor or CRO environment on the unmasked side Experience supporting Phase 3 clinical trials preferred Ophthalmology Preferred Other Qualifications/Skills:&nbsp; Working knowledge of clinical trial operations and ICH GCP guidelines Experience with TMF/eTMF systems (Veeva Vault preferred) Proficient in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) Strong organizational skills and attention to detail Ability to manage multiple priorities and meet deadlines Strong interpersonal skills and ability to collaborate effectively with cross functional teams and external partners Travel: Willingness to travel as business needs demand (&lt;15% anticipated) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Compensation range: $38.00 TO 52.00 /HOURLY Please note, the compensation range and actual rate offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY This Executive Director position will report to the Senior Vice President, Research &amp; Early-Stage Product Development and lead a team of translational scientists and drug development experts tasked with bringing innovative gene therapies to patients.&nbsp; The incumbent will have a high level of passion for 4DMT’s mission and the ability to operate as an effective strategic and tactical thinker. They will also be effective as a hands-on manager and supervisor of individual work. Candidates should have a PhD or MD/PhD degree (or equivalent) in Biological Sciences or a related discipline, with significant experience in pharmaceutical research and development.&nbsp; They will lead a preclinical and translational group responsible for: (1) developing target-engagement biomarkers and clinical biomarkers with relevance to Proof of Concept (POC) gene therapy studies, (2) conducting laboratory and in silico analyses of biomarker readouts generated in the relevant Phase 1 and Phase 2 gene therapy studies, (3) performing immunological assays and analyses relevant to detecting host immune responses to 4DMT gene therapy vectors in the clinical trial setting, and (4) overseeing outsourced performance of preclinical pharmacology and toxicology studies of 4DMT gene therapy vectors, in partnership with external CROs. This role will interact and collaborate with multiple functions at 4DMT, including but not limited to Clinical Science and Operations, Regulatory Affairs, Discovery &amp; Innovation, Commercial, and CMC. MAJOR DUTIES &amp; RESPONSIBILITIES: Set, communicate and drive strategy for Translational products in alignment with the broader organization of 4DMT Prioritize and allocate resources, both within Translational and beyond, to meet portfolio needs Lead the decision-making process with other relevant functional group heads regarding indications, targets and products’ progression from concept, design, preclinical development and Phase 1-2 clinical testing. Provide input on scientific strategy from the earliest consideration of new targets through development, including risk, scientific challenges, timing of resource investment and development of go/no go decisions ‪Direct and coordinate the implementation of preclinical study programs for pharmacology studies in support of the lead to candidate optimization process ‪Design, implement and write-up comprehensive series of pharmacology studies to address preclinical exposure, develop pharmacokinetics and pharmacodynamics profiles and generate GLP toxicology and bio-distribution packages suitable for supporting IND filings Manage budgets and headcounts ‪Design, implement and manage externally facing in vivo studies with CROs and academic centers, including drafting proposals, budget oversight and managing deliverables Resource planning; hiring and mentoring talents; building the team and technical capabilities Build collaborations with relevant functions at 4DMT; represent own function at the corporate level and externally Provide direct hands-on responsibility for all Translational interactions as well as grant writing and management with rare disease advocacy groups Participate on project teams and direct activities to ensure regulatory compliance of pre-clinical and clinical research activities Support regulatory affairs in their preparation, review and submission of necessary pre-clinical and clinical regulatory information to regulatory agencies worldwide Contribute to defining of clear human POC study outcome criteria for decision-making on new product candidates Contribute senior level expertise to alliance, business development, due diligence exercises with external entities and licensing meetings as well as other critical external interfaces such as public health regulatory bodies Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS:&nbsp; Education: PhD, MD/PhD, MD or equivalent Experience: 12+ years of relevant preclinical and/or translational sciences experience within the Biotech or similar industry 4+ years of management experience or other specific work experience Experience with preclinical, translational, and clinical R&amp;D Prior leadership position/s within the pharmaceutical/biotech industry or academic medical centers, with a significant history of research and translational experience Reputation for inspiring a culture of continuous improvement, innovation and quality, leading and mentoring at the highest level of achievement Skills: Team leadership skills and experience in a matrixed organization Ability to support and impact experts, scientists and project deliverables across functions in research, development and beyond Strong communication skills both written and oral with demonstrated ability to present ideas, information, and data effectively via one-on-one discussions, team meetings, and presentations to executive leadership Excellent time management skills (schedules, timelines, task prioritization) and the ability to adapt to changing priorities Self-starter who proactively establishes effective working relationships and builds partnerships with other disciplines Adaptability, flexibility, independence and resourcefulness; as an active participant in a vibrant small company culture, rolls up sleeves and manages multiple activities in parallel. Ability to proactively identify challenges; possesses strategic foresight and implements appropriate courses of action Excellent verbal and written communication skills Travel: 5-10% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $270,000 - 342,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Executive Director, Preclinical and Translational Sciences

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY 4DMT seeks a motivated and detail-oriented In-House Clinical Research Associate (IHCRA) to support the Company’s clinical trial activities. This position reports to the Associate Director, Clinical Operations, and will support the day-to-day execution of a Phase 3 clinical trial, including study start-up, conduct, and close-out activities. The IHCRA will serve as a key liaison between 4DMT, clinical sites, and CRO partners, with a focus on site support, monitoring oversight, regulatory compliance, and data quality. This role requires strong written and verbal communication skills, excellent organizational skills, and the ability to manage competing priorities while delivering high-quality work in a fast-paced, team-oriented environment. MAJOR DUTIES &amp; RESPONSIBILITIES: Clinical Trial Operations &amp; Site Support Support study execution across start-up, conduct, and close-out phases Serve as a primary point of contact for assigned clinical sites and CRO field CRAs/monitors Communicate directly with sites and CRO partners to obtain updates, resolve issues, and support study timelines Support site initiation, ongoing site management, and site close-out activities Assist with identification, documentation, tracking, and follow-up of site issues &nbsp;Monitoring Oversight Support oversight of CRO monitoring activities Review monitoring visit reports and follow up on action items and unresolved findings Track monitoring deliverables and escalate issues to the Associate Director, Clinical Operations as appropriate Support inspection readiness and audit activities &nbsp;Tracking &amp; Study Oversight Maintain accurate tracking tools for assigned studies, including: Site start up and activation status Subject enrollment and visit status Essential document collection and TMF status Vendor reconciliation Assist with preparation of study status reports and metrics &nbsp;Regulatory Documentation &amp; TMF Management Collect, review, and track site regulatory documents for completeness, accuracy, and compliance with applicable SOPs and regulatory requirements Ensure timely filing of documents in the TMF/eTMF in accordance with TMF plans Perform TMF quality control activities and support TMF audits and study close out &nbsp;Study Communications &amp; Meetings Support organization and coordination of internal team meetings, investigator meetings, and other study related meetings Prepare meeting materials, take meeting minutes, and maintain action item logs Support communication of study updates to internal stakeholders &nbsp;Additional Responsibilities Support ad hoc Clinical Operations projects as assigned Willingness to travel as trial needs demand (&lt;5% anticipated) Other duties as assigned, nothing in this position description restricts management’s right to assign or reassign duties and responsibilities to this position at any time&nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; A. or B.S. degree required Experience:&nbsp; Minimum of 1-2 years of experience supporting clinical trials in a sponsor or CRO environment Experience supporting Phase 3 clinical trials preferred Ophthalmology Preferred Other Qualifications/Skills:&nbsp; Working knowledge of clinical trial operations and ICH GCP guidelines Experience with TMF/eTMF systems (Veeva Vault preferred) Proficient in Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) Strong organizational skills and attention to detail Ability to manage multiple priorities and meet deadlines Strong interpersonal skills and ability to collaborate effectively with cross functional teams and external partners Travel: Willingness to travel as business needs demand (&lt;5% anticipated) Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Compensation range: $38.00 TO 52.00&nbsp; /HOURLY Please note, the compensation range and actual rate offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; The Principal Medical Writer will support 4D‑150, a gene therapy in late-stage development for retinal vascular diseases, including nAMD and DME, and associated BLA‑enabling activities as well as clinical stage work within the lung program. This role is responsible for the planning, development, and delivery of high‑quality clinical and regulatory documents across late‑stage development, working closely with Clinical Science, Clinical Operations, Data Science, Regulatory Affairs, Quality, and external partners. This role is expected to play a central role in BLA readiness, including oversight of the development, coordination, and execution of key BLA modules, and management of internal and external medical writing resources to ensure timely, high‑quality regulatory deliverables. The ideal candidate brings strong late clinical‑stage medical writing experience, demonstrated ability to manage complex timelines, and a deep understanding of regulatory expectations for global Phase 3 programs and BLA readiness. MAJOR DUTIES &amp; RESPONSIBILITIES:&nbsp; Provide oversight for the planning, development, and execution of BLA modules, working closely with Clinical Science, Regulatory Affairs, Data Science, and Quality to ensure alignment with submission strategy and timelines. Lead and coordinate external medical writers and vendors, including selection, scope definition, timeline management, content review, and quality oversight. Ensure consistency, scientific accuracy, and regulatory alignment across BLA components and supporting clinical documents. Serve as a key point of integration between internal subject matter experts and external writing resources to support efficient document development and review cycles. Author, review, and coordinate key clinical and regulatory documents for the 4D‑150 Phase 3 program as well as for the early-phase lung program, including but not limited to protocols, protocol amendments, CSRs, IBs, DMC materials, briefing documents, and BLA‑enabling content. Lead document planning and timeline management in collaboration with cross‑functional teams to support aggressive development milestones. Ensure consistency, clarity, and scientific accuracy across clinical documents, aligning with regulatory standards and internal expectations for quality. Partner closely with Clinical Science, Biostatistics, and Clinical Operations to integrate data interpretations, safety narratives, and efficacy analyses. Manage document review cycles, address comments, and ensure timely resolution of feedback from internal stakeholders and external vendors. Maintain document version control and adherence to internal SOPs, templates, and quality standards. Contribute to continuous improvement of writing processes, tools, and templates to support scale‑up of late‑stage development activities. Other duties as assigned QUALIFICATIONS:&nbsp; Education Advanced degree in life sciences (MS, PhD, PharmD, MD) preferred; Bachelor’s degree required. Experience 5+ years of medical or clinical writing experience in biotech, pharmaceutical, or CRO settings. Direct experience supporting Phase 3 clinical trials required; direct experience supporting early clinical trials (Phase 1/2) preferred. Prior experience authoring or contributing to BLA‑enabling documents strongly preferred. Other Qualifications / Skills Strong understanding of ICH guidelines, FDA regulatory expectations, and clinical development processes. Demonstrated ability to manage multiple complex deliverables under tight timelines. Excellent written communication skills with attention to scientific detail and clarity. Proven ability to work effectively in a fast‑paced, cross‑functional environment. Experience in gene therapy is a plus. Experience with leveraging AI-enabled tools to aid in document authoring is a plus. Travel Minimal; occasional travel (&lt;10%) as needed. Physical Requirements and Working Conditions: Sedentary work involving extended periods of sitting, typing, and screen use. Repetitive hand and finger movements required. Virtual meetings may occur across time zones. Base salary compensation range: $180,000 - 202,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Principal Medical Writer

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Director, FP&amp;A – TechOps serves as the primary finance business partner to the TechOps organization, providing end‑to‑end financial leadership across Manufacturing, Supply Chain, CMC Quality, and External Manufacturing as 4DMT transitions from late‑stage clinical development to commercial readiness and launch. This role is responsible for driving financial planning, forecasting, and decision support for a rapidly scaling TechOps organization. The Director will partner closely with TechOps leadership to translate operational plans into clear financial outcomes, proactively manage risks, and enable disciplined, data‑driven decisions. The position is expected to operate as a hands‑on, strategic individual contributor, with future people management potential as the organization scales. The Director role will report to the CFO and is expected on site&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: Act as the primary finance partner to TechOps leadership, supporting strategic planning, operational decisions, and investment prioritization Translate TechOps strategy, timelines, and operating plans into financial forecasts with implications, trade‑offs, and scenarios Own the TechOps annual budget, rolling forecast, and long‑range plan inputs through close coordination with business partners Develop and maintain detailed spend, headcount, and models aligned to clinical needs, manufacturing runs and launch timelines Ensure financial plans accurately reflect changes in demand, supply constraints, tech transfers, and scale‑up activities Lead scenario and sensitivity analyses to assess financial impact of operational risks and strategic alternatives. Deliver clear monthly variance analysis, forecasting updates, and KPI reporting for TechOps leadership and Finance. Support company‑wide cash flow forecasting and runway modeling, with particular focus on timelines and spend phasing QUALIFICATIONS:&nbsp; Education:&nbsp; Bachelor's degree in Accounting, Finance, or related field; CPA or MBA preferred Experience:&nbsp; 10+ years of progressive experience in FP&amp;A roles Prior biotech, pharmaceutical, or life sciences experience required Experience supporting a late‑stage clinical development organization through commercial launch (ideally first global product launch) required Experience with ERP selection and implementation Direct experience partnering with TechOps, Manufacturing, Supply Chain, and/or CMC organizations required Understanding of CMC processes (e.g. upstream, downstream, fill finish, pack and label, etc) Experience partnering with Clinical Development is a plus Skills:&nbsp; Proficiency in finance software (e.g., NetSuite, Adaptive) and Microsoft Excel Strong analytical and problem-solving skills, with the ability to interpret complex financial data and trends Excellent communication and interpersonal skills, with the ability to collaborate effectively across functional teams Detail-oriented, organized, and able to manage multiple priorities in a fast-paced environment Travel: &lt;5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $237,000 - 263,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Financial Planning and Analysis

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: Reporting to the Director, Supply Chain, this role is expected to work closely within the Supply Chain team, as well as cross-functional groups such as Clinical Operations and Quality. This is a remote or hybrid position. RESPONSIBILITIES: Supports the development and execution of Clinical Supply strategies for all 4DMT’s Phase 1/2/3 investigational drug products and ancillaries Coordinate and track bulk drug orders to ensure adherence to pre-defined supply and resupply timelines Monitor site inventory on a daily basis; coordinate and and track drug shipments to ensure uninterrupted supply Supports drug product inventory management and distribution in partnership with 4DMT’s clinical partners; evaluates drug utilization versus forecast considering country requirements and logistical timeline Maintains study and depot-level accountability and reconciliation documentation to support regulatory compliance and study closeout Tracks and resolves study and depot level temperature excursions. Provide routine reporting of drug wastage due to these excursions Archives Proof of Delivery (POD) documentation Maintain traceable documentation to support GXP activities Archives documentation on Trial Master Files as required QUALIFICATIONS: Education and Experience: Degree in biological or life sciences, pharmacy or medicine (or international equivalent). A minimum of 3 years in the pharmaceutical industry or relevant work experience and a minimum of 1 year in Clinical Supply Chain. Familiar in the daily management and operations of a Clinical Supply Chain inclusive of bulk management, distribution, and maintaining study blinds across multiple investigational products Experienced with Interactive Response Technology - IRT systems for inventory management and resupply Working knowledge of regulations relating to clinical labeling, packaging, and distribution activities; working knowledge of GMP/GCP/GLP regulations Skills: Intermediate/Advanced knowledge of Microsoft Suites Knowledge of Clinical Supply Management Solid written and verbal communication skills Excellent planning and organizational skills and the ability to work simultaneously on multiple projects with tight timelines Excellent interpersonal and communication skills Positive attitude with a strong desire for continuous learning Hourly compensation range: $58.00 - 70.00 &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Clinical Supply Specialist (Contract)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: Provide strategic and operational leadership for global clinical trial execution across the 4DMT lung portfolio. This role is responsible for delivering clinical programs aligned with corporate timelines, budget, quality, and regulatory expectations while building scalable operational infrastructure appropriate for a fast-paced biotechnology environment. The Director, Clinical Operations will lead internal Clinical Operations teams and external partners/CROs and collaborate with external teams to ensure efficient, high-quality, inspection-ready execution of Phase 1–3 clinical studies. This individual will serve as a key cross-functional leader and Clinical Operations subject matter expert, driving operational strategy, proactive risk mitigation, and execution excellence across global development programs. MAJOR DUTIES &amp; RESPONSIBILITIES: Develop and execute global clinical operations strategies aligned with corporate objectives, program timelines, budgets, quality standards, and regulatory requirements. Provide strategic operational leadership for Phase 1–3 clinical trials, ensuring efficient and compliant study execution across multiple global programs. Lead sponsor-side oversight and governance of CROs and critical vendors, including vendor selection, performance management, issue escalation, quality oversight, budget accountability, and operational delivery. Proactively identify, assess, and mitigate operational risks impacting timelines, enrollment, quality, budget, or regulatory compliance. Drive operational scalability and process optimization while maintaining execution excellence in a lean, fast-paced biotechnology environment. Develop and oversee global study timelines, resourcing strategies, and organizational planning across multiple dynamic programs. Build, mentor, and lead high-performing Clinical Operations teams, including hiring, talent development, performance management, and organizational growth. Partner closely with Therapeutic Area Heads (TAHs), Project Team Leaders (PTLs), Clinical Science, Regulatory Affairs, Biometrics, Quality, and other cross-functional stakeholders to ensure aligned program execution and timely decision-making. Serve as Clinical Operations representative and subject matter expert on cross-functional product development teams and governance committees. Provide operational leadership and support for clinical trial protocol development, feasibility assessments, country and site strategy, enrollment planning, and study startup activities. Lead Clinical Operations contributions to annual budget planning, quarterly forecasting, resource planning, and financial oversight for assigned programs. Ensure continuous inspection readiness across clinical programs, including oversight of TMF quality, audit preparedness, CAPA management, and health authority inspection support. Partner closely with Quality Assurance to maintain compliance with GCP, FDA, EMA, PMDA, ICH, and other applicable regulatory requirements and quality standards. Collaborate with Regulatory Affairs and Clinical Science to support regulatory submissions and ongoing compliance requirements, including ClinicalTrials.gov disclosures and global regulatory obligations. Contribute operational expertise to business development and due diligence activities, as applicable. Develop and present program updates, operational metrics, key risks, and mitigation strategies to senior leadership and executive management. Support development, implementation, and continuous improvement of SOPs, operational processes, and scalable infrastructure to support organizational growth. Foster a culture of accountability, collaboration, operational excellence, and clear cross-functional communication. Core Competencies, Knowledge &amp; Skill Requirements Demonstrated leadership in sponsor-side clinical operations within biotechnology and/or pharmaceutical environments. Proven ability to lead global Phase 2 and/or Phase 3 clinical trials with accountability for operational delivery. Strong experience managing CROs and external vendors from the sponsor perspective. Demonstrated ability to influence cross-functional stakeholders and drive decision-making in ambiguous or rapidly evolving environments. Strong operational and strategic leadership skills with ability to balance high-level portfolio strategy and detailed execution oversight. Ability to proactively identify operational risks and implement effective mitigation strategies. Proven ability to recruit, develop, retain, and motivate high-performing Clinical Operations teams. Strong financial acumen with experience managing clinical trial budgets, forecasts, and resource planning. Deep understanding of FDA, EMA, PMDA, ICH-GCP guidelines, and global clinical trial regulations. Experience supporting inspection readiness activities, audits, and regulatory inspections. Excellent organizational skills with the ability to manage multiple complex global programs simultaneously. Strong communication, presentation, negotiation, and interpersonal skills. Ability to operate effectively in a lean, fast-paced, and evolving biotechnology environment. High degree of accountability, ownership, adaptability, and execution focus. Communication &amp; Interpersonal Skills Excellent verbal, written, and presentation skills. Ability to communicate complex operational information clearly and concisely to technical and non-technical audiences, including executive leadership. Strong collaboration and relationship-building skills across internal teams and external partners. Demonstrated ability to influence without authority and drive alignment across cross-functional stakeholders. QUALIFICATIONS: Education: B.S./B.A. in Life Science or related discipline Advanced degree (M.S./M.A., MPH, MHS, MBA) preferred Experience: B.A./B.S. with 10+ years of applicable industry experience (Clinical Operations) in drug development, or advanced degree with 6+ years of experience across both early (Phase 1 or 2) and/or late-stage (Phase 3) 3+ years in a leadership role and with a minimum of 3+ years direct line management experience. &nbsp; Relevant experience in clinical trial execution across all phases. Other Qualifications/Skills: Proven ability to recruit, retain, organize, and motivate clinical operations personnel Ability to communicate to leadership team on Clinical Operations updates and priorities as well as to advocate for required budget and resources Ability to manage and oversee large scale programs that have corporate-wide impact Ability to develop and manage functional and clinical trial-specific budgets Must be self-motivating; prioritize and manage a large volume of work; show attention to detail Strong interpersonal skills are essential as this individual will partner with various team members and functional groups for clinical trials and business performance Thorough knowledge and understanding of FDA and ICH Guidelines, GCP, medical terminology, and clinical trials Ability to be flexible and adaptable to changing business needs Excellent communication and interpersonal skills Must be able to write clearly and summarize information effectively Must be able to present complex information to various audiences Base salary compensation range:&nbsp;$225,000 - 250,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp; &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Director, Clinical Operations (Lung Program)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY 4DMT is hiring a Sr. Quality Specialist, Document &amp; Records Management. Reporting to the Senior Manager, Quality Document &amp; Records Management, the Sr. Quality Specialist will be responsible for ensuring 4DMT's Quality Document &amp; Records Management is designed and executed in an efficient, compliant, and inspection ready manner. This individual will support the Senior Manager, Quality Document &amp; Records Management for the quality document and records management system, ensuring compliance with applicable GxP regulations, industry standards, and internal policies. In addition to driving process improvements and system optimization, this role will perform operational tasks to support document and record lifecycles. This role is hybrid and will require regularly scheduled time on-site at 4DMT's Emeryville office at least 3x a week. RESPONSIBILITIES: Quality Document Control &amp; Records Management System - 50% of the time: Serve as the point of contact for the Document Control system and quality-controlled records management. Support the development, enforcement, and improvement of policies, procedures, work instructions, templates, and forms related to document and records management. Collaborate closely with stakeholders (e.g., legal, clinical, regulatory, IT) to align record policies and lifecycles across platforms. Support centralized and decentralized quality-controlled record repositories (physical and electronic) for completeness, integrity, and retrievability. Support inspection readiness by ensuring all quality-controlled records are accessible, traceable, and compliant with data integrity and protection requirements. Support record audits, gap assessments, and remediation plans in preparation for regulatory inspections. Monitor, trend and report document control metrics (e.g., cycle time, overdue documents) Support internal and external audits and inspections. Provide guidance and training to system users and support documentation governance across departments. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time Quality Document Control &amp; Records Management Operations - 50% of the time: Perform document intake, advanced formatting, metadata review, routing, publishing, and obsoletion and ensure timely review, approval, and release. Support the management of periodic reviews of controlled documents. Advise document control participants on content and format to meet 4DMT procedural requirements, standards, templates, and best practices. Ensure compliance with document control procedures and applicable regulations. Collaborate with Quality Training to coordinate document and training lifecycles. Facilitate quality-controlled records management (e.g., onsite and off-site secure storage, retention, destruction) Identify and implement innovative methods to increase efficiency of operational tasks. QUALIFICATIONS:&nbsp; Education:&nbsp; Bachelor’s degree required, preferably in a scientific, technical, or related field. Experience:&nbsp; 6+ years of experience in document control and records management within the biotech, pharmaceutical, or medical device industry 2+ years in a hands-on system and/or process ownership role for a GxP EDMS (e.g., ACE, MasterControl, Veeva, etc.). 2+ years leading or supporting GxP records management operations. Comprehensive knowledge of FDA, EMA, ICH requirements and industry best practices for document control and records management Practical experience leading or actively participating in at least 1 EDMS or EQMS system implementation and/or significant enhancement project. Exposure to audits and health authority inspections ideally in a commercializing biotech environment. Domain knowledge of clinical research and development, manufacturing, quality, and/or IT is highly desirable. Skills:&nbsp; Extensive experience in document formatting using MS Word. Solid working proficiency in other productivity tools (e.g., Outlook, Teams, SharePoint, Excel, PowerPoint, Forms, DocuSign, Adobe Acrobat). Basic knowledge of or willing to learn analytical and reporting tools (e.g., PowerBI). Foundational understanding of change management principles Key Competencies Excellent interpersonal communication skills both written and verbal. Highly organized with the ability to multi-task and perform effectively under pressure. Proven project management, problem-solving, and organizational skills Demonstrated ability to collaborate, influence, and negotiate effectively. Motivated to seek out training and mentorship for professional development. Travel: 75%, to Emeryville. Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 - 20 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Hourly compensation range: $51.00 - 64.00 Please note, the hourly compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.&nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Senior Quality Specialist (Contract)

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY&nbsp; In this role, you will work both collaboratively within cross-functional teams — including colleagues, consultants, vendors, and MSPs — and independently to support day-to-day operations and project-based initiatives. The primary focus of the role is managing daily operational activities, including Tier 1 and Tier 2 IT Helpdesk support for end users and customers. Responsibilities include supporting lab equipment and applications (GMP and non-GMP), troubleshooting hardware and software issues, performing computer system validation activities (including change controls, validation execution, NCRs, AIRs, and CAPAs), maintaining data integrity and compliance, and administering system configuration, access management, security patching, and data backup processes. The ideal candidate is adaptable, service-oriented, and brings a broad technical skillset to effectively support evolving business needs.&nbsp; Hybrid schedule acceptable with a desire for 3-4 days onsite weekly.&nbsp; &nbsp; &nbsp;MAJOR DUTIES &amp;&nbsp;RESPONSIBILITIES:&nbsp; Execute &amp; comply with&nbsp;4DMT SDLC, Change, Access, Inventory, &amp; operational management procedures for&nbsp;business‑critical&nbsp;applications &amp; platforms.&nbsp; Support evaluation, pilot testing, selection,&nbsp;&amp; ongoing&nbsp;management of IT vendors &amp; partners aligned to business &amp; compliance requirements.&nbsp; Lead or support validation of computerized systems &amp; laboratory instruments, including installation, configuration, troubleshooting, &amp; documentation (SOPs, IQ/OQ/PQ).&nbsp; Ensure ongoing data integrity, backup, &amp; regulatory compliance for GMP laboratory &amp; manufacturing systems.&nbsp; Provide technical input &amp; support for Investigations, Change Controls, CAPAs, decommissioning, &amp; audit readiness activities.&nbsp; Participate in or lead Periodic Reviews, User Access Reviews, &amp; Audit Trail Reviews for GMP systems.&nbsp; Execute &amp; support UAT activities, collaborating with IT &amp; business teams on issue resolution.&nbsp; Deliver&nbsp;hands‑on&nbsp;operational support for QC &amp; Manufacturing instrument systems, including break/fix support &amp; reliability issues in&nbsp;validated&nbsp;&amp; production environments.&nbsp; Manage user account provisioning &amp; deactivation in compliance with access control SOPs.&nbsp; Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time &nbsp; &nbsp;QUALIFICATIONS: &nbsp; Education: &nbsp; Bachelor’s degree in Information Technology, Computer Science, Life Sciences, or a related field with at least 5+ years of relevant experience in a laboratory environment or biotech/pharma setting; or&nbsp; Master’s degree with 3–5+ years of relevant experience&nbsp; &nbsp;Experience: &nbsp; Strong operational knowledge of laboratory IT environments, including instrument connectivity &amp; client/server architectures.&nbsp; Proficiency&nbsp;in Windows OS administration (registry, system files, security, local accounts &amp; policies).&nbsp; Working knowledge of network technologies (VLANs, firewalls, security protocols, instrument LANs).&nbsp; Familiarity with virtualization platforms (e.g., VMware, Citrix VDI).&nbsp; Experience supporting validated systems in a regulated&nbsp;GxP&nbsp;environment is&nbsp;required.&nbsp; Knowledge of 21 CFR Part 11, Annex 11, data integrity, and CSV process&nbsp; Familiarity with&nbsp;broad&nbsp;range of lab instrumentation and Enterprise IT solutions used in Biopharma, e.g., LC systems (Waters/Agilent), AKTA,&nbsp;SoftMaxPro,&nbsp;Geneious, ELN/LIMS (Sapio), Imaging Systems, Bioreactors, Plate readers, Sequencers, etc.&nbsp; &nbsp;Travel:&nbsp;None&nbsp; &nbsp;Physical Requirements and Working Conditions:&nbsp; Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force&nbsp;frequently&nbsp;or constantly&nbsp;to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are&nbsp;required&nbsp;only&nbsp;occasionally&nbsp;and all other sedentary criteria are met.&nbsp; Base salary compensation range: $47.00 - 60.00&nbsp; Please&nbsp;note,&nbsp;the base salary compensation range and actual salary offered to the final candidate&nbsp;depends&nbsp;on&nbsp;various factors:&nbsp;candidate’s&nbsp;geographical location, relevant work experience, skills, and years of experience. &nbsp; &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

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