4D Molecular Therapeutics is a leading biotechnology company specializing in gene therapy, founded in 2013. The company is at the forefront of developing innovative therapies using cutting-edge technology to address genetic diseases. 4D Molecular Therapeutics is revolutionizing the field of medicine with its groundbreaking approach to gene therapy, offering promising solutions for patients with previously untreatable conditions.

Sr. IT Support Engineer

Vice President, Late-Stage Clinical Development

Associate Director - External Engagement

Senior Medical Director - Ophthalmology (Retina) Remote

Sr. Maintenance Technician

VP, Medical Affairs

Associate Director, Medical Affairs Operations

Sr. Manager, Audit Program

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY: &nbsp; In this position, you’ll work closely with HR leadership and the team to ensure HR operations run smoothly, compliantly, and with a focus on continuous improvement. The Manager, HR Operations &amp; Systems will own core HR processes and compliance requirements while also playing a major role in the execution of key HR programs, including performance management, talent acquisition, learning &amp; development, and employee engagement. This role is responsible for maintaining accurate employee data, stewarding HR systems, driving automation and efficiencies, and delivering analytics that provide insights into workforce trends. This role helps ensure both the HR team and the broader organization are set up for success. &nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; HR OPERATIONS: Own and continuously improve HR operations processes (onboarding, offboarding, employee changes, documentation, records management). Maintain and update SOPs to ensure compliance and effectiveness. Partner with Finance, IT, and Payroll to ensure timely and accurate processing of employee data and changes. Serve as point of contact for HR service requests, escalating as needed. Regularly evaluate HR operations to identify opportunities for simplification, standardization, and improved employee experience. &nbsp; HR COMPLIANCE: &nbsp; Own compliance activities across HR, including policy administration, record retention, and regulatory reporting. Ensure HR processes and documentation meet requirements of SOX, D&amp;I, federal/state laws, and other regulations applicable to a publicly traded company. Conduct audits of employee files, HR data, and HR processes to ensure accuracy and compliance. Partner with Finance, IT, and external vendors on compliance-related audits. Monitor and integrate new regulations and best practices into HR policies, processes, and the employee handbook. &nbsp; HR TECHNOLOGY: &nbsp; Administer current HR systems, including user access, permissions, and documentation. Ensure HR data accuracy, integrity, and compliance with SOX controls, data privacy, and record retention requirements. Partner with IT and vendors to maintain existing tools, evaluate effectiveness, and make incremental improvements where needed. Provide user support and training for HR systems to ensure adoption and consistency. Drive automation and process efficiencies within HR operations Identify areas of improvement with current HR systems to optimize utilization and efficiency through enhancements and integration of different tools. Explore and evaluate AI-powered HR technologies to automate tasks and improve data analysis, collaborating with IT and HR partners to pilot solutions, monitor effectiveness, and recommend scalable integration. &nbsp; &nbsp; HR PROGRAMS &amp; ANALYTICS: &nbsp; Lead the operational and systems aspects of HR programs throughout the year, including performance management, talent acquisition processes, learning &amp; development, and employee engagement initiatives. Partner with HR leadership and program owners to coordinate timelines, communications, and execution steps to ensure successful delivery. Train HR team members and employees on how to navigate and use HR systems and resources effectively. Maintain accurate program documentation and monitor utilization to evaluate effectiveness. Develop and deliver HR analytics and reporting that provide insights into workforce trends, headcount, and program outcomes to inform decision-making. Continuously evaluate HR programs and processes to identify opportunities for improvement and alignment with organizational goals. &nbsp; &nbsp; QUALIFICATIONS: &nbsp; Education: Bachelors required &nbsp; Experience: &nbsp; 6+ years of progressive HR experience, with strong emphasis on HR operations, systems, and compliance. 3+ years of experience managing HR Operations is preferred. Experience supporting Sox compliance for a publicly traded company. Experience with one or more of the following tools a plus: Greenhouse Recruiting, ChartHop, Leapsome, Nectar. &nbsp; Other Qualifications/Skills:&nbsp; Hands-on experience with ADP Workforce Now (maintenance, data integrity, user support). Strong knowledge of HR compliance requirements, record retention, and reporting. Demonstrated ability to manage and improve HR operations processes. Proficiency in Excel, PowerPoint, and HR reporting. Highly organized with strong attention to detail and documentation skills. Excellent written and verbal communication; able to partner effectively across teams. Customer-service orientation with ability to balance employee experience and compliance requirements. &nbsp; Travel: 0-10% &nbsp; Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $135,000/yr - $165,000/yr &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Manager, HR Operations & Systems

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY The Senior Director, Medical Affairs, Ophthalmology will contribute to the development and execution of the medical affairs strategy in Ophthalmology. This role will collaborate with clinical development, clinical development operations, scientific communications, external engagement, biometrics, data management, regulatory affairs, drug safety, commercial, and alliance partners. The Senior Director will develop and/or substantially contribute to the implementation of the portfolio strategy and life cycle management planning across indications. The successful candidate will be responsible for cross-functional communication and collaboration across the organization to ensure the execution of global medical affairs strategy across all geographic regions ensuring a cohesive approach for the franchise. This role will lead medical affairs activities ensuring partnership within the team (medical strategy, scientific communications and publications) and across all key Medical Affairs functions (Medical Excellence, HEOR, Field Medical, Medical Information) to ensure alignment and one 4DMT approach. This role will also be the key medical affairs lead for scientific and clinical training initiatives. Reporting to the VP, Medical Affairs, this individual contributor role will serve as a subject matter expert to internal and external stakeholders. Depending on location, this role may be fully remote or hybrid. *Experience in retinal disease is required as well as strong Phase III study support and launch preparedness. MAJOR DUTIES &amp; RESPONSIBILITIES: Assist in development of the medical strategy for entry into new indications and across indications ensuring this fits within the overall company strategy and maintaining cross functional alignment. Deliver on critical identified milestones. Provide input for cross functional partners including clinical development and commercial to ensure that there is a strong medical voice represented. Demonstrate strategic thinking to translate medical/clinical insights of treatment paradigms into growth opportunities, while driving competitive advantage. Act as scientific reviewer, contribute to company sponsored medical affairs research programs and external research, and lead the creation of a robust scientific education plan for healthcare professionals and other stakeholders as well as internal for global medical training, field medical leadership across all regions and HEOR. Build external relationship network for existing and new indications to help drive trial enrollment, launch prep, and gain advice. Provide direction into publication planning and review, medical backgrounders, FAQ and standard responses, internal training approach, and data dissemination. Develop full thought leader engagement strategic approach and ensuing plan and provide insight to the cross functional medical engagement plans. Deliver high quality educational presentations internally and externally, as required. Ensure a comprehensive and synergistic approach by collaborating across Medical Affairs, Regions, and other functions including Commercial and Development. Operate in a fully compliant manner in all internal and external interactions. Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS:&nbsp; Education:&nbsp; Advanced degree required (PharmD/PhD/OD/MD) or equivalent degree with relevant therapeutic specialty in the pharmaceutical industry, community, academic or hospital environment required. Direct clinical experience in ophthalmology (MD/OD) preferred. Experience:&nbsp; 7+ years of medical affairs experience in the pharmaceutical industry, academia, or equivalent. Deep ophthalmology therapeutic area expertise strongly preferred. Ability to interact externally and internally to support a global scientific and business strategy. Extensive knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials, and experience in development of clinical strategy and the design of study protocols. &nbsp; Other Qualifications/Skills:&nbsp; Must possess excellent oral and written English communication skills. Ability to exercise judgment and address complex problems and create solutions across multiple projects. Pre-launch preparation and launch experience strongly preferred Retina experience required, candidates with existing relationships within the retina community strongly preferred Global medical affairs experience a strong plus Travel: up to 60%, domestic and international Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $276,000/yr - $337,000/yr4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Sr. Dir, Medical Affairs

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; &nbsp; The Senior Medical Director is accountable for the design, execution, and analysis of clinical trials in the Ophthalmology Therapeutic Area.&nbsp; &nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES:&nbsp; Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.&nbsp; Serves as medical monitor on clinical studies. Serves as the primary clinical author of development plans, study protocols, amendments, ICFs,&nbsp; IBs, INDs, annual reports, CSRs, regulatory submissions / correspondence, and project-related documents. Accountable for the accuracy of all medical content of such documents. Works with the research organization and the portfolio management team to identify and support new project opportunities. Collaborates to identify program risks, and to create and implement mitigation strategies Other duties as assigned &nbsp; QUALIFICATIONS:&nbsp; &nbsp; Education:&nbsp; Medical Degree (M.D.) Residency training in Ophthalmology with a preference for subspecialty training in retina Board certification a plus Retina fellowship training a plus Experience:&nbsp; 8+ years of clinical ophthalmology research in the biopharmaceutical industry Experience with Phase 3 retina clinical trials Experience with gene therapy a plus. Experience in other phases (Phase 1, 2, 4) of clinical research a plus. Experience with NDA/BLA/MAA submission a plus. Experience writing clinical research protocols and acting as a medical monitor&nbsp; Experience in data analysis, data interpretation, and medical writing &nbsp; Other Qualifications/Skills:&nbsp; Knowledge of ICH-GCP and FDA regulatory guidelines. Knowledge of international regulatory guidelines a plus. Effective written and verbal communication skills, including public speaking &nbsp; Travel: 15% (3 days/month) &nbsp; Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). &nbsp; Base salary compensation range: $315,000/yr - $390,000/yr4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Sr. Medical Director

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. &nbsp; 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol deliveryGENERAL SUMMARY:&nbsp; The incumbent will focus on providing strategic input and technical expertise on statistical methodology to support the research and development organization for assigned projects. They will participate as active members of a cross-functional team to plan, lead and execute the tasks required to support the assigned programs.&nbsp; MAJOR DUTIES &amp; RESPONSIBILITIES: &nbsp; Provide statistical expertise and collaborate with various functions on study design/planning, protocol development, statistical methodology/analysis Responsible for the development of statistical analysis plan (SAP), TFL shells and other analysis specifications on assigned studies Responsible for the development of randomization schema on assigned randomized studies Perform data analysis and/or collaborate with statistical programming (inhouse or vendor) to ensure quality analysis conducted per the SAP and specifications Responsible for the development of statistical reports summarizing the data analysis results Ensure adequate interpretation of data/analysis results and consistency/accuracy of data presentation for study reports and publications Collaborate with various functions to ensure robust CRF/EDC development, and quality data collection for the assigned clinical trials Provide quality review of outsourced statistical deliverables (including inhouse double programming to QC as needed) and coordinate the inhouse review comments Stay abreast of industry development in biostatistics/statistical programming fields and apply to appropriate systems and processes Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time&nbsp; &nbsp; QUALIFICATIONS:&nbsp; Education:&nbsp; Advanced degree (M.A./M.S. or PhD) preferred, or equivalent experience Experience:&nbsp; A./M.S. with 8+ years, or PhD with 5+ years in biotech/pharmaceutical industry Experience in ophthalmology and/or biologic/gene therapy a plus Experience with all clinical phases (I, II, III, and IV) is desirable Other Qualifications/Skills: Good understanding of standards specific to clinical trials such as CDISC, SDTM, and ADaM, MedDRA, WHODRUG Knowledge of applicable GCP/FDACHMP//ICH/HIPPA regulations Displays excellent organization and time management skills, excellent attention to detail, and ability to multi-task in a fast-paced environment with shifting priorities and/or conflicting deadlines Excellent written and verbal communication skills and strong team player with demonstrated track record of success in cross-functional team environment Travel: &lt;5% Base salary compensation range: $194,000/yr - $234,000/yr &nbsp;4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. &nbsp; Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

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