Vaxcyte is a biotechnology company focused on developing novel vaccines to address infectious diseases.

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Working closely with the General Counsel and reporting to the Executive Director, Associate General Counsel, the Director, Senior Counsel will enjoy a high-visibility and high-impact role supporting cross-functional teams. The emphasis of this role will be on drafting, negotiating, executing, and managing contracts with company vendors as well as industry partners, government agencies, and CROs. Additionally, there will be exposure to other legal areas such as compliance. Essential Functions: Prepare and negotiate a wide variety of agreements, including commercial, consulting, vendor, supply, master service, licensing, collaboration and development, joint venture, sponsored research, CRO, manufacturing, confidentiality, and other agreements essential to Vaxcyte’s business. Provide counsel to, and participate in strategy discussions with, internal stakeholders to ensure the Company’s contracts meet strategic objectives while mitigating corporate risk. Lead the continuous improvement of law department operations through problem solving, strategic planning, project management, process, and systems improvement (include contracts management systems), and financial/budget management, including through the implementation of new software tools. Define contracting processes and systems and provide necessary reports and project status information to management and other appropriate staff. Oversee outside counsel engagements, manage department budget, and implement cost‑containment and efficiency initiatives. Advise internal clients regarding legal issues, including identifying, managing, and communicating risks and opportunities in commercial transactions. Support continuous improvements of forms, policies and processes to help streamline and simplify deals and product/service terms. Develop and maintain strong working relationships with internal and external business partners as well as other members of the legal team. Requirements:&nbsp; Juris Doctor degree with exceptional academic credentials. Must hold and maintain an active law license in a jurisdiction that permits the attorney to lawfully provide the required legal services, in accordance with all applicable laws, regulations, and rules of court. Minimum 6-10+ years of legal experience drafting, structuring, and negotiating agreements, including commercial, consulting, vendor, supply, master service, licensing, collaboration and development, joint venture, sponsored research, CRO, manufacturing, confidentiality, and other agreements essential to Vaxcyte’s business. Other combinations of education and/or experience may be considered. In-house legal experience at a biotechnology, pharmaceutical, or biopharmaceutical company is a plus. Experience managing contracts processes and policies and using contracts lifecycle management (CLM) tools (e.g., Ironclad). Hands‑on experience implementing and administering CLM systems and legal‑tech tools including AI applications; aptitude for leveraging data analytics to drive decisions. Experience handling commercial contract disputes and dispute resolution. Experience driving cost-saving initiatives. Experience using AI tools such as Spellbook and ChatGPT Enterprise. Excellent analytical skills; creative, pragmatic problem-solving abilities in a transactional context; and efficient, precise drafting of customized agreements. Excellent analytical, communication and organizational skills, and demonstrated ability to effectively collaborate and manage several simultaneous projects under deadline pressure. Experience working on FDA regulatory and quality assurance matters is preferred. Reports to: Executive Director, Associate General Counsel &nbsp; Location: Hybrid/Open to remote with the ability to work West Coast hours &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $236,000 - $270,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Senior Counsel

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a highly skilled, energetic and experienced candidate to join our Information Technology (IT) organization as Senior Manager, IT Master Data Management (MDM). This critical role involves active participation in the implementation of our SAP Enterprise Resource Planning (ERP) System. This role is key in defining and managing master data and associated processes within and beyond the ERP ecosystem, helping to implement requisite management and reporting/analytics tools, and establishing a comprehensive data governance framework. The ideal candidate will bring deep master data management expertise within the biotech industry, experience in building master data governance, and designing data solutions for the reporting and analytics inclusive of master data elements. This role must have strong analytical skills and the ability to collaborate cross-functionally to drive strategic and operational insight and excellence.&nbsp; Essential Functions: SAP Master Data Management Actively participate in the SAP S/4HANA project. Responsible to identify and ensure precise and efficient integration of master data as ERP MDM Lead. Oversee creation, maintenance, and governance of master data across SAP modules (e.g., Materials, Vendors, Customers, GL Accounts, Departments). Collaborate with business units to define data standards, naming conventions, and data quality rules. Take lead to ensure data quality and resolve issues related to master data. Help establish and co-lead (with Supply Chain) a Data Governance Council to uphold data integrity and best practices. Define and manage master data management processes to align with business objectives. Develop and implement strategies to improve data accuracy and consistency across ERP and related functions. Design and implement data validation and cleansing routines. Work closely with technical teams to architect and build reporting/analytical solutions inclusive of master data elements. Monitor and report on data management performance and identify continued areas for improvement. Maintain compliance with industry regulations and standards related to data management. &nbsp; Data Analytics and Reporting Develop and maintain scalable data pipelines and integrations into enterprise data lakes. Build and support dashboards, visualizations, and KPIs using tools like Power BI, Tableau, or SAP Analytics Cloud. Collaborate with business stakeholders to gather reporting requirements and translate them into technical solutions. Utilize advanced data analysis to support business insights, forecasting, and strategic initiatives. Ensure data security, privacy, and compliance in all analytics work. &nbsp; Requirements:&nbsp; B.S. / B.A. degree in Business Administration, Information Systems, Data Science, or a related field. Advanced degree or relevant certifications preferred. 8+ years of experience supporting ERP initiatives within Life Science industries. Deep understanding of SAP ERP systems (S/4HANA) and master data structures. Experienced in SAP Master Data Management and respective tools. Hands-on experience with data integration fundamentals and designing analytical solutions (i.e., data lakes, analytical reports, dashboards, etc.). Proven experience with analytics tools including SAP Analytics Cloud, Azure, Tableau. Proficiency in data visualization and dashboarding tools (e.g., Power BI, Tableau, SAP Analytics Cloud). Strong SQL skills; experience with Python or R is a plus. Strong analytical and problem-solving abilities. Ability to analyze complex data and make data-driven decisions. Solid knowledge of ERP processes and data areas including Finance, Procurement, Inventory, HR. Excellent verbal and written communication skills. Ability to effectively communicate with stakeholders at all levels of the organization. Demonstrated leadership and team management skills. Ability to lead and motivate cross functional teams to achieve high levels of performance. Strong organizational skills with the ability to manage multiple activities simultaneously and meet deadlines. High level of accuracy and attention to detail in all aspects of work. Strong interpersonal skills with the ability to build and maintain effective relationships with internal and external stakeholders. Ability to thrive in a fast-paced, dynamic environment and adapt to changing priorities and requirements. Reports to:&nbsp;Senior Director, IT Enterprise Systems &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $182,000 - $212,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, IT Master Data Management

Director, Environmental, Health, & Safety (EH&S)

Senior Manufacturing Systems Analyst

Senior Associate Scientist, Upstream Polysaccharide Process Development

Sr. Regulatory Document Formatting Specialist

Clinical Data Manager

Associate Director, Clinical Quality Assurance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: Vaxcyte is seeking a highly skilled and experienced candidate to join our Commercial Manufacturing and Supply Chain (CSMC) organization. This critical role entails active participation in the implementation of SAP Enterprise Resource Planning System and OMP Advanced Planning System, building master data capabilities, processes and tools and team from the ground up.&nbsp; The role excels at collaborating across various supply chain functions and establish a comprehensive data governance framework, process, tools, and team. The ideal candidate brings deep master data management expertise within the biotech industry, experience in building master data governance, processes and a strong team from the ground up, strong analytical skills, and the ability to collaborate cross-functionally to drive strategic and operational excellence.&nbsp; Essential Functions: Oversee the management of master data for supply chain, manufacturing, logistics, direct procurement, and quality functions. Define and manage the data management process to align with business objectives. Establish and lead a Data Governance Council to uphold data integrity and best practices. Actively participate in the SAP and OMP APS implementation projects, responsible to ensure precise and efficient integration of master data. In the mid-to-long term, build and lead a team responsible for master data management in SAP and OMP Advanced Planning System. Develop and implement strategies to improve data accuracy and consistency across the supply chain. Collaborate with cross-functional teams to ensure data quality and resolve issues related to master data. Monitor and report on data management performance, identifying areas for improvement. Maintain compliance with industry regulations and standards related to data management. Requirements:&nbsp; B.S. / B.A. degree or advanced degree (preferred) Minimum 10 years of supply chain experience within the biotechnology or pharmaceutical industries&nbsp; Has completed multiple SAP S/4 HANA lifecycle implementations in master data roles Proven track record successfully building and growing master data management programs and teams Proficient in SAP ERP Master Data Management, GMP data standards, and respective tools&nbsp; Strong analytical and problem-solving abilities. Capable of analyzing complex data and making data-driven decisions In-depth understanding of supply chain processes, including manufacturing, logistics, procurement, and quality Excellent verbal and written communication skills. Ability to effectively communicate with stakeholders at all levels of the organization Demonstrated leadership and team management skills. Ability to lead and motivate cross-functional teams to achieve high levels of performance Strong organizational skills with the ability to manage multiple activities simultaneously and meet deadlines High level of accuracy and attention to detail in all aspects of work Strong interpersonal skills with the ability to build and maintain effective relationships with internal and external stakeholders Ability to thrive in a fast-paced, dynamic environment and adapt to changing priorities and requirements Reports to: Senior Director, Supply Planning, Inventory Management and Systems &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $174,000 - $202,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Supply Chain Master Data Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director for Drug Substance (DS) Commercialization of Critical Raw Materials will lead and facilitate launch readiness and commercial supply of critical raw materials for production of eCRM and associated components for glycoconjugate vaccines. In this role the incumbent will serve as the technical lead and SME on biologic raw material processes . This role focuses on technical launch planning and execution by bringing best-practices and coordinating cross-functional efforts for regulatory filings, facility readiness, launch supplies and post-launch process robustness initiatives. This role also provides leadership to ensure that the organization is equipped to effectively communicate the scientific and commercial rationale for critical raw material manufacturing processes to internal stakeholders, relevant CMOs, and to regulatory agencies. The incumbent will work with the organization to ensure on-time execution and appropriate planning for commercial lifecycle management. This position will be reporting into the Sr. Director for Global DS Commercialization, Protein. The Director will collaborate on overall program strategy, with primary responsibility and accountability for assigned critical raw material strategy, subject matter expertise and associated regulatory filings and supporting studies. Global Manufacturing Science and Technology (GMSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. As part of the Technical Operations organization, GMSAT will lead the technical and process support for end-to-end commercial manufacturing, including Polysaccharides, Carrier Proteins, and Conjugation across all Drug Substances (DS). The range of activities will include technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle, etc.&nbsp; Essential Functions: DS Commercialization – Provide strategic and scientific leadership for critical raw materials with internal and external stakeholders and ensure successful execution of launch plans and post-launch commercial activities. Process robustness – Continuously improve process understanding and process robustness using staff and laboratory resources across the organization to monitor, trend, and optimize operations. Interface - Collaboration with cross-functional teams across the network, including Regulatory, Process Development, Quality, Supply Chain, Procurement, and DS Operations, to drive the successful development and commercial launch of critical raw materials for pipeline products. Tech-transfer new technologies - Ensure robust processes exist to support technical transfers and integration of new technologies. Support technical services - Support of our internal and external manufacturing network, including materials management and data analytics. Process validation and comparability - Provide leadership for the execution of process validation and process comparability activities. Effectively communicate the scientific and commercial rationale for raw material processes to the Manufacturing organization for commercialization Regulatory - Engage In technical reviewing and authoring of regulatory filings and responding to questions received from health authorities. Effectively communicate the scientific and commercial rationale for DS processes to the Boards of Health for regulatory submissions for commercialization. Communicate - Effectively and efficiently communicate process performance to key stakeholders (internal-facing and external-facing). Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Leadership - Contribute as Strategy lead for assigned Critical Raw Materials and as member of the DS Commercial MSAT team, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Travel - 10-30% travel required. Requirements:&nbsp; Degree(s) in Organic Chemistry, Biochemistry, Chemical or Biochemical Engineering, or related discipline with a minimum of 10+ years of relevant experience for Ph.D., 12+ years for M.S./M.A., or 16+ years for B.S./B.A. Extensive experience in scale-up, technology transfer, and relevant manufacturing process technologies /unit operations, including fermentation, recovery and purification at commercial scale. Experience with cell free protein synthesis and associated critical raw materials desired. Experience in manufacturing equipment specification/qualification and commercial manufacturing in a GMP environment is preferred. Experience working with Contract Manufacturing Organizations is desired. Leadership experience in MSAT or Process Development in supervisory and/or matrixed team roles. Able to leverage deep technical knowledge in a collaborative manner to troubleshoot technical challenges, establish strategic plans, and achieve collective goals. Excellent organization, problem solving and strategic planning skills. Highly skilled in both verbal and written communication with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges, and directs activities to implement effective solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Senior Director, Global Drug Substance Commercialization Lead, Protein &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $219,000 - $256,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Global Drug Substance Commercialization, Critical Raw Materials

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a QA Manager who will serve as the Quality Assurance representative overseeing Vaxcyte’s stability program for our products. The responsibilities include, but are not limited to, reviewing and approving stability protocols, reports, data, and expiry/retest records, providing QA oversight of the stability studies conducted at Contract Manufacturing Organizations (CMOs) and Contract Testing Labs (CTLs), and managing Stability documents in Veeva. The QA Manager will also manage change controls, deviations, and CAPAs related to stability. Essential Functions: QA Representative for quality management of the stability studies for Vaxcyte products. Key participant in quality team focused on the oversight of stability studies at CMOs and CTLs. Review and approval of stability protocols and reports. Review and approval of stability data and release data, as required. Review and approval of expiry and retest documentation for Vaxcyte products. QA representative for change controls, deviations and CAPAs associated with the stability program. Work closely with Stability, Project Management team, other functional areas, and external vendors for management of routing, revisions, approval, and filing of Stability documents in Veeva (electronic document control system) within defined timelines. Develop, implement and maintain procedures and policies. Support process improvement initiatives. Review and assess temperature excursions. Represent QA at internal and external cross functional tactical team meetings. Interact with key stakeholders to develop solutions to complex issues. Promote a quality mindset and quality excellence approach to all activities. May participate in compliance audits as required. Escalate issues impacting the safety, efficacy and shelf-life of stability material to appropriate management. Requirements:&nbsp; BS or BA with minimum 5 years of relevant industry experience. Other combinations of education and/or experience may be considered. Demonstrate in-depth knowledge of GMPs, FDA regulations and ICH guidelines. Knowledge in both clinical and commercial product desired. Demonstrate excellent verbal, written, and interpersonal communication skills, collaborative approach essential. Demonstrate experience leading and contributing through influence and working in cross functional teams. Experience working with Contract Manufacturing Organizations. Strong sense of ownership for areas of responsibilities. Knowledge of JPM, NovaStability and Veeva is desired. Reports to: Senior Manager, Quality Assurance &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $151,000 - $176,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Assurance, Stability

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director, EH&amp;S, will provide both strategic leadership and hand-on experience to ensure Vaxcyte’s laboratories, offices and manufacturing environments remain safe, compliant and scalable for growth.&nbsp; This role is central to building and sustaining a strong culture of safety while supporting operational efficiency across global sites.&nbsp; The Director will develop and lead comprehensive EHS programs – including, but not limited to, laboratory and office safety, regulatory compliance, risk management, ergonomics, emergency preparedness and sustainability – while guiding Vaxcyte through its next phase of expansion. A successful candidate is well organized, flexible, creative and enjoys the challenges of managing a diverse and energetic office space. This is a full-time, on-site role that reports to the Senior Director of Facilities. Note: 24x7 support is required of this role.&nbsp; You must be able to respond for urgent support. Essential Functions: EHS Leadership &amp; Strategy Develop, implement, and oversee global EHS programs, policies, and training across all Vaxcyte facilities. Maintain a multi-year strategic roadmap to align safety initiatives with company growth and product pipelines. Chair the Safety Committee and foster a culture of accountability, awareness, and continuous improvement. Sets department environmental and safety priorities and goals consistent with company objectives. Maintain a three (3) year strategic roadmap to ensure alignment and readiness for future growth and vaccine pipelines. Regulatory Compliance &amp; Risk Management Ensure compliance with OSHA, EPA, local, state, federal, and international regulations. Oversee chemical inventory, SDS management, waste disposal, and hazardous materials programs. Lead audits, inspections, job safety analyses, and corrective/preventive actions (CAPA). Partner with Quality and Compliance teams to maintain up-to-date standards and internal controls. Responsible and accountable for all Environmental, Health and Safety programs including, but not limited to: Emergency Response, Emergency Action Plans (EAP), Respiratory Protection Plan (RPP), Injury and Illness Prevention Program (IIPP), Ergonomics, Hearing conservation, Medical Waste, Biological Safety and Exposure Control, Chemical Hygiene and Hazard Communication, etc. Operational Excellence Implement lean practices (e.g., 5S, Kanban, visual management) to drive efficiency and reduce risk. Partner with Biological Safety Officer to implement and maintain a Biological Safety Program. Manage external vendors and service providers related to EHS programs. Collaborate with Facilities, Lab Operations, and scientific teams to integrate EHS into daily workflows. Emergency Preparedness &amp; Training Lead emergency response planning, including the Emergency Action Plan (EAP) and Emergency Response Team (ERT). Design, deliver, and track employee and laboratory safety training. Serve as the primary contact for incident response, investigation, and resolution. Requirements:&nbsp; Bachelor’s degree in science or engineering related discipline (Master’s preferred). Minimum 12 years of progressive experience in laboratory operations experience managing and scaling lab operations in a biotechnology or pharmaceutical research environment. Ten (10) years with a master’s degree. Other combinations of education and/or experience may be considered. Experience managing EHS programs across labs, offices, and GMP manufacturing sites. Proven global experience across North America, UK, and EMEA (APAC/APJ a plus). Strong understanding of GMP, GLP, and GDP requirements. Professional certifications (CSP, CIH, CHMM) strongly preferred. Excellent leadership, communication, and collaboration skills. Demonstrated ability to develop new safety programs and SOPs from the ground up. Ability to travel up to 10% (domestic and international). Reports to:&nbsp;Senior Director, Facilities &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $195,000 - $228,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Environmental Health & Safety

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our Analytical Development team. Primary responsibility for the incumbent will be to support the developmental activities currently on going in the laboratory as assigned. Essential Functions: Assist in the design, execution and interpretation of experiments to analyze drug substances and intermediates such as proteins and carbohydrates including: Microplate assays include enzymatic assays. HPLC- Especially SEC and RP-HPLC with experience in Chemstation. CE and iCIEF – Especially with Protein Simple or PA-800 systems. Assist in analytical method development of new assays. Keep accurate and detailed records of experiments. Summarize data and communicate to analytical team. Support daily lab operations, sample inventory and sample shipment. Work within a team environment and provide support to further team objectives. Complete any assigned tasks with high quality and in a timely manner. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 2+ years of relevant lab experience, or MS with 1+ years of experience. Other combinations of education and/or experience may be considered. Ideal candidate will have a background in analytical chemistry principles and hands-on experience with modern analytical instrumentations commonly used in the analysis and characterization of drug candidates. Candidates with other scientific disciplines may be considered based on relevant experience. Experience in chemical and biological assays such as colorimetric/fluorometric microplate assays and HPLC. Experience working with protein analysis – UV-Vis, CE, Bradford etc. Experience working with carbohydrate analysis and SEC-MALS a plus. Understanding of basic principles of analytical method development/validation/ qualification concepts. Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data. Strong interpersonal skills: ability to communicate effectively both verbally and in written formats. Ability to work under supervision and independently in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease. Reports to:&nbsp;Manager, Analytical Development &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $105,000 – $124,000 (SF Bay Area). Salary ranges for non-California locations may vary.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Analytical Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director, Quality Assurance will serve as the Site Quality Assurance lead for Drug Substance manufacturing activities at Ibex, ensuring all operations performed at Contract Manufacturing Organizations (CMOs) meet Vaxcyte’s quality standards and global regulatory requirements. This role acts as the primary QA representative across internal and external cross-functional teams, providing oversight of deviations, investigations, risk assessments, change controls, and CAPAs. The Director will conduct detailed reviews of batch records, disposition packages, and technology transfer documents, driving timely issue resolution with CMOs and escalating risks as needed. In addition, this position will develop and enhance QA procedures, support continuous improvement initiatives, and contribute subject-matter expertise on biologics manufacturing and Quality Systems in alignment with Global procedures requirements, and initiatives. The ideal candidate brings deep GMP knowledge, strong communication and collaboration skills, and the ability to thrive in a fast-paced, matrixed environment while managing multiple priorities. Essential Functions: Site QA Manufacturing representative for Drug Substance at Vaxcyte. Represent QA at internal and external cross functional team meetings. Review and approve internal and external documentation for compliance such as deviations, risk assessments, change controls, and CAPAs. Responsible for thorough QA review of CMO executed batch records in compliance with current regulatory guidance and industry practices and follow up on CMO responses. Review disposition package of Drug Substance per global applicable regulatory requirements and provide to management for release. Develop, implement and maintain procedures and policies as they apply to Drug Substance manufacturing for the Vaxcyte quality organization as needed. Drive resolution of quality performance issues with contract manufacturers and proactively escalate issues to Vaxcyte management. Provide guidance on supplier manufacturing investigations. Support technology transfer activities and review of technology transfer documents. Participate in process improvement projects. Interact with key stakeholders to develop solutions to complex issues while promoting quality standards of excellence. Requirements:&nbsp; BS or BA with at least 10 years Quality Assurance experience. In-depth knowledge of GMPs, FDA/EMA regulations and ICH guidelines. Strong attention to detail. Knowledge in both clinical and commercial product desired. Excellent verbal, written, and interpersonal communication skills. Experience leading and contributing through influence and working in cross functional teams. Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Ability to adapt to changing priorities. Strong overall knowledge of biologics manufacturing processes and Quality Systems. Required experience with good documentation practices, technical writing, and cGMP standards. Other combinations of education and/or experience may be considered. Reports to: Senior Director, Quality Assurance &nbsp; Location: Visp, Switzerland &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1 We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Quality Assurance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for a Facilities Engineer to be responsible for the maintenance and improvement of our office and laboratories. The Facilities Engineer will be responsible for maintaining and upgrading lab and office spaces throughout the San Carlos, CA campus. You will be responsible for assessing the facility's resource requirements, designing, and optimizing the facility's layout and critical operational systems, and overseeing the maintenance of infrastructure and equipment. The successful Facilities Engineer should be able to develop and implement utility plans, perform system evaluations, and establish operational efficiency. A top-notch Facilities Engineer should have excellent project management skills and strong knowledge of structural and building code requirements. They should also have an energetic professional who thrives wearing multiple hats, has a wide range of operational office and lab responsibilities, and is able to think and work independently. A successful candidate is well organized, flexible, creative and enjoys the challenges of managing a diverse and energetic office space. This is a full-time, on-site role that reports to the Facilities Engineering Manager. Essential Functions: &nbsp;Ability to analyze data, blueprints, and reports. Perform all corrective maintenance for all facility assets such as RODI systems, HVAC, hot water heaters, compressor/vacuum skids, gas regulators and gas distribution systems. Perform preventative maintenance on all facility assets. Determine facility requirements (space, utilities, gases, etc.) and make assessments for lab equipment based on the equipment specifications and requirements. Make recommendations for equipment locations and any supporting utilities. Support developing specifications and implementation of facility and lab equipment, equipment layout, other facility and lab systems, and controls. Evaluate operational systems, facility and lab infrastructure to ascertain and improve operational efficiencies. Develop space optimizing and resource allocation plans. Plan and coordinate facility and lab infrastructure and equipment maintenance schedules and activities. Work with external and internal facility vendors. Install new laboratory and facility equipment. Perform preventive maintenance and repair work on office mechanical, electrical, doors, and other installed systems, and lab equipment. Maintain all Vaxcyte HVAC systems and associated equipment, electrical equipment, plumbing and gas systems, building management system (BMS), and office and lab repairs. Maintain and assure the proper function of the facility and its Mechanical, Electrical, Plumbing and DI Water Systems including repairing minor malfunctions of any of the components in and around the facility. Coordinate maintenance contractors performing maintenance activities. Perform necessary functions of our BMS system, fire/life safety, and other systems required for facilities. Prepare reports and compliance documentation. Ensure compliance with relevant regulations, building codes, and health and safety standards. Perform facility inspection and report on conditions affecting operations. Comply with all safety procedures and requirements. Process work requests and turn in completed work requests in a timely and professional manner. Respond to emergencies and support after-hours office/lab needs and activities as required using the REES monitoring system for freezers etc. Assist lab operations team in troubleshooting equipment. Possess knowledge and working understanding of Computerized Maintenance Management System (CMMS) systems supporting building and lab equipment is a plus. Requirements:&nbsp; Associate’s degree in mechanical, electrical, or industrial engineering. Minimum 5 years of experience as a facilities engineer, biotechnology metrology or in a similar role. Other combinations of education and/or experience may be considered. Demonstrated experience and knowledge of CMMS systems. Must be able to create new assets in the system, input/upload equipment information, pull equipment preventative maintenance work orders, create new work orders as needed, upload documents, close out maintenance or repair orders. Demonstrated ability to work alone and accomplish assigned tasks without instruction or oversight. Knowledge of the building process and construction principles. Knowledge of relevant safety regulations and building codes. Good verbal and written communication skills. Ability to read technical documentation and apply to programming, troubleshooting, repairing or maintaining equipment. Troubleshooting and problem-solving skills. Project management skills. High level of integrity and ethics with the ability to maintain confidentiality. Strong organizational and interpersonal skills. Ability to manage multiple priorities efficiently. Desire to work in a fast-paced environment. Intermediate PC skills including MS Office suite. Must be able to efficiently use computers to write reports, emails, and provide written communication to leadership. Standing, Walking, Sitting, Reading, Stooping, climbing Ladders, crawling in / through low spaces. Heavy Lifting and Moving, Computers and Related Equipment, Heavy Equipment up to 70 lbs. &nbsp; Reports to:&nbsp;Facilities Engineering Manager &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $118,000 - $139,000 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Facilities Engineer

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Senior Manager, Immunoassay to join our team. The position will be an integral part of the team responsible for method validation/transfer and cGMP-compliance in routine operations for immunoassays performed for all phases of clinical development for Vaxcyte’s PCV product. The primary responsibility will be the QC lead for method validation/transfer of immunoassays and include supporting of the quality control activities including cGMP analytical testing at Contract Testing Organizations and Vaxcyte QC laboratory operations. The ideal candidate will apply technical expertise, strong cGMP experience, ensure compliant operations and documentation, foster open communication, and pursue data-driven approaches.&nbsp; Essential Functions: Author/Review validation and transfer protocols, data and reports for immunoassay and bioanalytical assays. Collaborate with internal stakeholders to set appropriate validation/transfer acceptance criteria. Collaborate with and interface with key internal stake holders to understand immunoassay and bioanalytical methods being performed onsite and at CMOs. Apply technical and compliance expertise to the review of immunoassay and bioanalytical test methods and in-process/release protocols, data and CoAs from CMOs. Provide technical and compliance feedback to internal and external stakeholders who have developed the immunoassay and bioanalytical methods. Manage outsourced cGMP and characterization testing supporting lot release. Manage sample submission forms, shipping and sample handling activities required between the CMOs to support on time validation immunoassay and bioanalytical assays. Serves as the QC liaison for outsourced immunoassay development, technology transfer and data management in a CRO or CMO/CDMO environment. Accountable for execution of quality control testing and supportive processes including sample /inventory management, scheduling, documentation, compliance review, results reporting (CoA), and scientific interpretation of data / method performance to ensure high quality data and control of immunoassay and bioanalytical methods. Responsible for quality event management (deviations, investigations, change control) related to immunoassay and bioanalytical assays. Author SOPs, technical reports and multiple regulatory submission when needed, and address health authority questions during various clinical phase filings. Work with others to identify opportunities for continuous improvement and implement/maintain solutions. Provide strong teamwork in establishing a quality culture and shared accountability. Requirements:&nbsp; PhD. in Biochemistry or immunology with 4+ of industry experience; MS or BS with 8 + years of industry experience in Pharma / Biotech industry required. GMP experience is required. Other combinations of education and/or experience may be considered. A proven track record of developing complex GLP or GMP immunoassays and solving bioanalytical problems. Thorough understanding and hands-on experience of the MSD multiplex platform and troubleshooting is required. Previous experience in validation and transfer of immunoassay and bioanalytical assay and method development experience is highly desired. Ability to integrate and interpret interdisciplinary project information, with at least a high-level understanding of the drug/vaccine development process. Ability to work globally with CMOs in different countries and continents. Ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members. Fundamental understanding of statistics and data analysis software, proficient with analytical software such as Softmax Pro. Strong interpersonal skills; ability to communicate effectively both verbally and in written formats. Solid understanding of relevant FDA, EU, and ICH regulatory guidelines and pharmacopeia as applicable to immunoassay method qualification/validation for biologics and vaccines and demonstrated ability of applying the regulatory guidance to formulate practical solutions and phase appropriate analytical strategy. Experience in IND, NDA and BLA submission is preferred. Project management skills including the ability to manage project resource requirements (material, manpower, time, etc.), and ability to elevate relevant issues to project lead and line-management. Strong interpersonal skills; ability to communicate effectively both verbally and in written formats. Reports to: Senior Vice President, Clinical Serology, Nonclinical &amp; Immunoassay Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $161,000 – $188,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Immunoassay

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly skilled and motivated Senior Associate Scientist to join our Analytical Development team at Vaxcyte. The primary responsibility will be to support characterization of drug substances, intermediates and drug products by LCMS or other appropriate analytical methods. The ideal candidate will embody and uphold our core values of rethinking convention, aiming high, leading with heart, and modeling excellence in all aspects of their work. Essential Functions: Independently perform and complete laboratory assignments with high quality and in a timely manner. Prepare samples and execute analytical procedures according to the SOP. Perform critical data analysis. Assist in design, developing and implementing mass spectrometry-based workflows for characterization of proteins, conjugates, and other in-process molecules. Operate, maintain, and troubleshoot mass spectrometry instruments. Document results of analyses and experiments with an electronic notebook system. Support cross-functional teams with their analytic needs based on mass spectrometry. Interpret, communicate, and present findings and results regularly at group meetings. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Biochemistry/Molecular Biology considered, with 5+ years of relevant industry experience, or MS with 3+ years of experience. Other combinations of education and/or experience may be considered. Strong knowledge on mass spectrometry technologies, including Orbitrap, QTOF and triple quadrupole. Knowledge of NMR is a plus. Hands-on experience with peptide mapping and intact analysis by LCMS. Experience with peptide quantitation is preferred. Highly organized, strong attention to details and excellent record keeping/documentation abilities. Demonstrate critical thinking and scientific curiosity while approaching complex problems. Eager and able to learn and understand new concepts with ease. Strong people skills and ability to communicate effectively with other team members. Ability to work under supervision and collaborate effectively with other team members in a demanding environment. Reports to:&nbsp;Staff Scientist &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $118,000 – $138,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist, Analytical Development for Characterization

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Director, Global Logistics has overall responsibility for shipping and storage of all Vaxcyte CMC materials including finished goods, bulk product and samples. Scope includes Research, Development, Clinical and Commercial material. This position will report to the Executive Director, Global Supply Chain. Essential Functions: Ensure all shipping and storage operations are compliant, do not impact product quality, timely and cost effective Select and Manage carriers, freight forwarders, 3rd party storage site, import / export brokers and other logistics service providers Ensure robust shipping agreements are in place with all CMOs and suppliers of criterial raw materials Ensure that packouts are robustly designed with the appropriate containers and associated components to maintain material at target temperature and facilitate efficient receipt Oversight of all logistics related policies, guidelines and standard operating procedures Development and maintenance of IT systems to track shipping requests, actual shipments and temperature data. Ensure that temperature excursions and other logistics related deviations occur at low frequency and are resolved in a compliant and timely manner with minimal material losses. Ensure the successful design &amp; execution of a Shipping Validation Program Ensure Import / Export Trade Compliance in all relevant markets Ensure tariff obligations are managed in a compliant and cost effective way. Develop and implement finished good distribution strategies for all global markets that Vaxcyte launches in Select and manage a US 3PL site that will store Vaxcyte Finished Goods, process customer orders, execute shipments and collect payments. Interface with Commercial, Quality, Finance, IT, Process Development, Regulatory, MSAT, Supply Planning, Clinical Supply, Supplier Management and other Functions Manage a team of logistics professionals Requirements:&nbsp; BS in a science-related discipline is a definite plus. 10+ years’ experience working in the Life Sciences industry. 10+ years’ experience in International cGMP cold chain shipping Fluent with all global shipping-related statutory and regulatory requirements. Understand the requirements, technologies, and processes of cold-chain supply management. Experience with pharma logistic service providers with knowledge of qualified active and passive containers. Experience with arranging international and domestic transportation. Experience authoring and using GxP documents such as SOP’s and work instructions. Relentless focus and passion around process improvements (efficiency and automation). Excellent communication, customer service, and relationship skills. Vaccine distribution experience highly valued. All Vaxcyte employees require vaccination Reports to: Executive Director, Global Supply Chain &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $260,000 – $303,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Sr. Director, Global Logistics and Distribution

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Manager for Drug Substance (DS) Commercialization has the accountability for launch readiness and commercial supply of critical raw materials for production of eCRM and associated components for glycoconjugate vaccines. This role focuses on technical launch planning and execution by bringing best-practices and coordinating cross-functional efforts for regulatory filings, facility readiness, launch supplies commercial supply of critical raw materials for production of eCRM and associated components for glycoconjugate vaccines and post-launch process robustness initiatives. This role also provides leadership to ensure that the organization is equipped to effectively communicate the scientific and commercial rationale for critical raw material processes to internal stakeholders, relevant CMOs, and to regulatory agencies. The incumbent will work with the organization to ensure on-time execution and appropriate planning for commercial lifecycle management. This position will be reporting into the Senior Director for Global DS Commercialization, Protein. The Senior Manager will collaborate on overall program strategy, with primary responsibility for supporting development and execution of biologic critical raw material process strategy, troubleshooting and robustness study design and execution for critical raw materials. Global Manufacturing Science and Technology (GMSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. As part of the Technical Operations organization, GMSAT will lead the technical and process support for end-to-end commercial manufacturing, including Polysaccharides, Carrier Proteins, Conjugation across all Drug Substances (DS). The range of activities will include DS technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, and investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle etc.&nbsp; Essential Functions: DS Commercialization – Provide strategic and scientific leadership for critical raw materials with internal and external stakeholders and ensure successful execution of launch plans and post-launch commercial activities. Process robustness – Continuously improve process understanding and process robustness by putting systems in place to monitor, trend, and optimize operations. Interface - Collaboration with cross-functional teams across the network, including Regulatory, Process Development, Quality, Supply Chain, Procurement, and DS Operations, to drive the successful development and commercial launch of carrier proteins for pipeline products. Provides technical representation into initial technology transfer, product launch, product lifecycle, to the end of life/product retirement and for defining/developing the next generation of production technologies. Tech-transfer new technologies - Ensure robust processes exist to support technical transfers and integration of new technologies. Support technical services - Support of our internal and external manufacturing network, including materials management and data analytics. Process validation and comparability - Provide support for the execution of process validation and process comparability activities. Regulatory - Engage In technical reviewing and authoring of regulatory filings and responding to questions received from health authorities. Effectively communicate the scientific and commercial rationale for DS processes to the Boards of Health for regulatory submissions for commercialization. Communicate - Effectively and efficiently communicate process performance to key stakeholders (internal-facing and external-facing). Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Executing for Results - Set clear and challenging goals and take accountability for driving results. Comfortable with ambiguity and uncertainty; the ability to adapt nimbly and lead others through complex situations. Leadership - Contribute as member of the DS Commercial MSAT team, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Travel - 10-30% travel required. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 5+ years of relevant experience for Ph.D., 8+ years for M.S./M.A., or 12+ years for B.S./B.A. Broad experience in protein processes, including bacterial fermentation, recovery, and purification across multiple operational scales. Experience with cell free protein synthesis and associated critical raw materials desired. Leadership experience in MSAT or Process Development in supervisory and/or matrixed team roles. Able to leverage deep technical knowledge in a collaborative manner to achieve collective goals. Excellent organization, problem solving and strategic planning skills. Highly skilled in both verbal and written communication with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges and independently identifies and implements effective steps and solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Senior Director, Global Drug Substance Commercialization Lead, Protein &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Global Drug Substance Commercialization, Critical Raw Materials

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is&nbsp;&nbsp; looking&nbsp;&nbsp; for&nbsp;&nbsp; a highly motivated and skilled individual to join Vaxcyte’s Vaccine Product Development organization as a Sr Associate Scientist in the Protein Development and Clinical Manufacturing group. The successful candidate will play a crucial role in designing, implementing, and optimizing automation solutions to establish high throughput fermentation process development workflows. The successful candidate will have the following skills and qualities:&nbsp; Proven experience in designing, programming, and implementing laboratory automation systems A passionate researcher with a knack for technology innovation to improve performance and efficiency An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals. Strong organizational and planning skills. Essential Functions: Be part of the Ambr operation team and execute high throughput upstream process development experiments. Design and develop automation solutions for liquid handling, sample preparation and analysis workflows. Collaborate with Vaxcyte Benchling to enable efficient data capture from automated processes. Diagnose and troubleshoot technical issues related to automation hardware, software, and protocols. Author SOPs (standard operating procedure) and train laboratory personnel on the proper operation, maintenance, and troubleshooting of automation systems. Requirements:&nbsp; BS in Chemical Engineering or Chemistry/Biochemistry with 5+ years of relevant Pharma/Biotech industry experience, or MS in Chemical Engineering or Chemistry/ Biochemistry with 3+ years of relevant Pharma/Biotech industry experience. Strong understanding of laboratory workflows in biotech process development. Familiarity with various automation platforms and technologies, such as liquid handling robots, robotic arms, and plate readers. Experience with Tecan Fluent, Biomek i-series, and/or Ambr 250HT system is a plus. Knowledge of data analysis and visualization tools. Excellent problem-solving skills and attention to detail. Effective communication skills and the ability to collaborate with cross-functional teams. Reports to:&nbsp;Senior Scientist, Upstream Development for Protein Development &amp; Manufacturing &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $118,000 – $138,000&nbsp;(SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist, Upstream Development for Protein Development and Manufacturing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Manager for End-to-End Process Validation &amp; Technical Regulatory Liaison is accountable for leading the strategy and execution of global process validation activities across the vaccine drug substance portfolio. This role owns the planning, execution, and lifecycle management of process validation, ensuring compliance with regulatory expectations and industry best practices. The Senior Manager provides leadership for cross-functional validation programs spanning polysaccharides, carrier proteins, conjugation, drug substance intermediates and drug product. This role is also accountable for authoring and reviewing regulatory documentation to support successful global filings, health authority interactions, and lifecycle management of commercialized products. The position reports into the Senior Director for Global Process Validation and will collaborate on overall program strategy, with primary responsibility and accountability for validation strategy and regulatory deliverables. Essential Functions: End-to-End Process Validation Lead strategy and execution of process validation, including process design, qualification, and continued verification. Drive alignment with global health authority requirements (FDA, EMA, PMDA, etc.) for validation programs across multiple modalities. Ensure technical robustness of validation approaches through risk assessments, process characterization, and CPV implementation. Regulatory Documentation Author and critically review regulatory submissions (INDs, BLAs/MAAs, supplements, responses to information requests, and briefing packages). Translate complex technical data into clear, concise regulatory documentation aligned with global health authority expectations. Serve as technical liaison with Regulatory Affairs to ensure timely and high-quality submissions. Cross-Functional Leadership Partner with MSAT, Process Development, Quality, Supply Chain, and Regulatory to ensure seamless execution of validation and regulatory deliverables. Provide strategic input during technology transfers, lifecycle changes, and introduction of new manufacturing sites. Support responses to health authority queries and participation in regulatory inspections. Process Robustness &amp; Lifecycle Management Establish systems to monitor, trend, and improve process performance across the product lifecycle. Lead technical assessments for process changes and comparability evaluations to maintain product quality and supply continuity. Identify and implement best practices for sustaining process robustness and compliance. Data Management Acquire and gather data from manufacturing nodes throughout the supply chain to enable regulatory filings, process monitoring, and continuous improvement.&nbsp; Support data verification for all commercial regulatory submissions.&nbsp; Communication &amp; Leadership Communicate process validation strategy and outcomes effectively to senior leadership, regulatory bodies, and external partners. Build and develop a high-performing team with expertise in validation and regulatory documentation. Foster a culture of compliance, scientific rigor, and operational excellence. Travel - 10–20% travel required to global manufacturing sites and regulatory interactions. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with minimum of 8+ years of relevant experience. Demonstrated leadership in process validation, CPV, and regulatory submissions in a biologics or vaccine environment. Broad technical knowledge across biologics processes (fermentation, purification, conjugation, formulation). Proven experience authoring high-quality regulatory submissions and supporting health authority interactions. Strong organizational, problem-solving, and strategic planning skills. Excellent written and verbal communication skills with the ability to convey complex scientific concepts clearly. Demonstrated ability to proactively identify risks and implement mitigation strategies. Track record of building and mentoring teams to achieve collective goals. Reports to: Senior Director, Process Validation &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $158,000 – $184,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Process Validation

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly skilled and experienced Senior Director, Supply Chain, ERP Transformation, to join our dynamic team. As we transition from a clinical-stage organization to a fully integrated commercial biotech company, we are building the foundational capabilities essential to reliably deliver our first commercial vaccine to patients. The Senior Director, Supply Chain ERP Transformation role will play a pivotal leadership role in designing and implementing the end-to-end processes required to support this transformation. This is a business role and not a technology role. In this role, you will lead a team of process leaders in developing and executing Plan-to-Deliver capabilities—including planning, scheduling, production, quality release, and logistics—as well as overseeing the comprehensive Direct Procure-to-Pay process, including purchasing, receiving and inventory management, quality release, and reconciliation. The ideal candidate is well-versed in industry standards and best practices that are scalable, compliant, and aligned with our future-state operating model. You bring deep supply chain expertise, proven cross-functional leadership, and a strong track record of driving transformation through effective business process and technology alignment. If you are passionate about building leading-class supply chain capabilities and enabling organizational transformation in a fast-paced, innovative environment, we invite you to apply and make a meaningful impact on the future of healthcare. Essential Functions: Serve as the Global Business Process Owner: Own and champion the end-to-end Plan-to-Deliver and Direct Procure-to-Pay value streams with Business Process Leaders, ensuring processes are integrated, optimized, and aligned with organizational objectives. Lead Process Design and Standardization: Drive the development and implementation of robust, scalable, and compliant supply chain processes that will support Vaxcyte’s transition to a commercial-stage operation. Strive to balance agility, efficiency, and compliance while standardizing workflows. Act as a Change Leader: Inspire and guide stakeholders through transformational change, fostering a performance-driven culture and embracing new ways of working to unlock organizational potential. Integrate Business Process and Technology: As a core member of the SAP Project PMO, ensure business processes and ERP capabilities are harmoniously integrated to deliver the intended target-state business outcomes and sustain long-term value. Drive Cross-Functional Collaboration: Build and nurture strong partnerships across Supply Chain, Manufacturing, Quality, Regulatory, Procurement, Finance, IT, and Commercial functions. Facilitate alignment and collaboration across both clinical and commercial supply chain operations. Establish Data Governance Strategy: Define and execute a comprehensive data governance framework to enable to the Plan to Deliver and Direct Procure to Pay Business Processes, ensuring data integrity and accuracy, reliability, and operational efficiency. Develop and Implement Metrics and KPIs: Design, deploy, key performance indicators to monitor and assess process effectiveness, identify improvement opportunities, and drive a culture of continuous improvement. Oversee SOP and Documentation Development: Lead the creation and maintenance of standard operating procedures and business process documentation to support operational readiness and ensure compliance with Health Authority inspection requirements. Lead and Mentor Cross-Functional Teams: Manage, inspire, and develop a high-performing team of business professionals, cultivating an environment of continuous learning, growth, and operational excellence. Collaborate with Executives and Senior Leaders to ensure strategic alignment between ERP, operational initiatives, and corporate objectives, providing critical insights and recommendations to inform decision-making and drive enterprise-wide results. Requirements:&nbsp; Bachelor's degree in supply chain management, business administration, or a related field. A master's degree or professional certification (e.g., APICS, CSCP) is preferred. 12+ years of experience in supply chain, manufacturing, procurement, quality functions, preferably within the biotechnology industry. Proven track record of success in a senior management role. Has held Business Process Owner/Lead roles previously with significant experience designing biotech business processes Proficiency in SAP ERP is required and OMP Advanced Planning Systems is preferred. Has completed multiple full life-cycle SAP S/4 HANA implementations Strong analytical and problem-solving abilities. Ability to analyze complex data and make data-driven decisions. Exceptional verbal and written communication skills. Ability to effectively communicate with stakeholders at all levels of the organization. Demonstrated leadership and team management skills. Ability to inspire and motivate a team to achieve high levels of performance. Strong project management skills with the ability to manage large complex projects and meet deadlines. High level of accuracy and attention to detail in all aspects of work. Ability to thrive in a fast-paced, dynamic environment and adapt to changing priorities and requirements. Strong interpersonal skills with the ability to build and maintain effective relationships with internal and external stakeholders. Reports to: Senior Director, Supply Planning, Inventory Management and Systems &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $211,000 - $246,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Supply Chain, ERP Transformation

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: The Associate Director for Global ASAT Polysaccharide (PS) will lead and facilitate the analytical (tech transfer and lifecycle of commercial manufacturing) program prioritization, and execution to drive the successful launch of products. This role provides leadership in validation and &nbsp;implementation of analytical methods to characterize and ensure the quality of polysaccharide for drug substances throughout the lifecycle of commercial manufacturing, with a focus on understanding and controlling critical quality attributes (CQAs) of the polysaccharide, adhering to all relevant regulatory standards and guidelines. Works in alignment with network organization to ensure on-time execution and appropriate planning for commercial lifecycle management and coordinating cross-functional efforts for regulatory filings, facility readiness, and launch supplies. This role also provides leadership to ensure that the organization is equipped to effectively communicate the analytical and scientific rationale for polysaccharides and DSI testing to internal stakeholders, relevant CMOs, and to regulatory agencies. The incumbent will work with the organization to ensure on-time execution and appropriate planning for analytical readiness and lifecycle management for commercial manufacturing. Reporting to the Senior Director for Global ASAT, the Director will collaborate on overall program strategy, with primary responsibility and accountability for the analytical leadership for commercial drug substance (DSI and DS) functions across the network. Essential Functions: The ASAT group will focus on qualifying/validating, and optimizing analytical methods/technologies used in the commercial manufacturing process and through its life cycle. The ASAT Associate Director for PS will support the commercial analytical control strategy (release and characterization) including establishing the analytical methods for DSI and DS. The ASAT PS will support commercial operations as well as quality control (QC) on all aspects of analytical methodology and heightened characterization studies for polysaccharide. &nbsp; PS Commercialization - Provide technical and scientific advice for internal and external stakeholders in support of the successful execution of launch plans and post-launch commercial activities. Support the analytical control strategy with advanced state-of-the-art analytical equipment and technologies and routine trouble shooting. Life Cycle Management of process and product. Analytical validation and comparability - Validate new analytical techniques and methods. Provide leadership for analytical validation and comparability activities. Effectively communicate the scientific and commercial rationale of analytical aspects to the Manufacturing organization for commercialization. Analytical Characterization - Provide analytical support activities related to method qualification/validation, product characterization, and comparability assessment for multiple programs. Tech Transfer - Provide technical support for complex analytical challenges. Tech-transfer new technologies - support technical transfers and integration of new technologies. Lead Tech Transfer Support (including comparability protocols and reports). Support Technical Teams - Support of our internal and external manufacturing network, including materials management and data analytics. Review/Author method validation protocols, reports, and transfer activities. Review analytical documents including but not limited to protocols, reports, and procedures. Regulatory - Engage in support of reviewing and authoring of regulatory filings and responding to questions received from health authorities. Effectively communicate the scientific and commercial rationale for analytical to the Boards of Health for regulatory submissions for commercialization. Contribute to CMC analytical aspects of regulatory filings; review and assemble information for analytical sections in regulatory submission documents (e.g. IND, IMPD, NDA, etc). Support World-Wide Post Approval Submissions. Analytical thought partner - Serve as a thought partner with Regulatory, CMC, Quality, Supply Chain, Sourcing, and Process Engineering colleagues. Interface - Collaboration with cross-functional teams across the internal and external network to drive the successful development and commercial launch of pipeline products. Work in a team environment to manage third-party vendors including analytical method implementation, qualification/validation, and transfer for drug substance and drug product projects. Communicate - Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Leadership - Contribute as Global ASAT lead and as a member of the Global Manufacturing Operations, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Act as the CMC team analytical lead member in cross functional developmental teams. Leadership - As a member of the Global ASAT organization, lead matrixed teams focused on analytical lifecycle of test methods for commercialization with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Travel - 10-30% of travel required. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 9+ years of relevant experience for Ph.D., 11+ years for M.S./M.A., or 14+ years for B.S./B.A. Other combinations of education and/or experience may be considered. Extensive experience in analytical method development, validation, method transfer, commercial launch, and/or analytical lifecycle management of polysaccharides and/or glycoconjugate vaccines preferred. Demonstrated ability to coordinate CDMO activities and direct experience with directing outsourced assay validation, stability, and quality control in support of CMC activities. Leadership experience in analytical development, QC, ASAT or MSAT in supervisory and/or matrixed team roles. Able to leverage deep technical knowledge in a collaborative manner to establish strategic plans and achieve collective goals. Excellent organization, problem solving, and strategic planning skills. Highly skilled in both verbal and written communication with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges and directs activities to implement effective solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Senior Director, Global Analytical Sciences and Technology (ASAT) Lead &nbsp; Location: San Carlos, CA; Open to remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $173,000 - $201,000 *(SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Global Analytical Sciences and Technology (ASAT) Polysaccharide

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: As we grow, we are seeking a strategic and collaborative Associate Director of Data and Knowledge Management to ensure the integrity, accessibility, and effective use of data and knowledge assets across the organization. The Associate Director of Data and Knowledge Management will lead enterprise-wide efforts to structure, govern, and utilize data and knowledge resources critical to our process development, clinical, regulatory, and operational activities. This role is instrumental in ensuring scientific data integrity, regulatory readiness, and the preservation of institutional knowledge in a dynamic, fast-paced clinical environment. Essential Functions: Data Management, Strategy &amp; Governance: Acquire and gather data from manufacturing nodes throughout the supply chain to enable regulatory filings, process monitoring, and continuous improvement. Develop and oversee data management strategies to support operations, development, and regulatory submissions. Own data verification for all commercial regulatory submissions. Lead the integration of structured and unstructured data across departments (e.g., preclinical, clinical, regulatory, CMC). Knowledge Management: Build systems and workflows to capture and retain organizational knowledge, including protocols, study results, lessons learned, and decision rationales. Develop tools and processes that enable scientific teams to find, share, and reuse knowledge efficiently. Champion a knowledge-sharing culture across scientific and operational functions. Collaboration &amp; Leadership: Partner with regulatory, quality, R&amp;D, IT and contract manufacturing teams to understand data and knowledge needs and align solutions. Lead cross-functional initiatives focused on digital transformation, data harmonization, and collaboration tools. Manage and mentor a team of data professionals, analysts, and knowledge specialists. Analytics &amp; Insights: Ensure timely access to high-quality data for operational decision-making. Partner with data science team to drive data visualization, reporting, and insights. Support the use of AI/ML and automation for improved data analysis and knowledge extraction. Compliance &amp; Risk Management: Ensure compliance with data protection and clinical trial regulations, including GDPR, HIPAA, and 21 CFR Part 11. Identify and mitigate risks related to data security, access, and retention Requirements:&nbsp; Bachelor’s, Master’s or PhD degree in Life Sciences, Data Science, Information Management, or related field. Minimum of 9+ years of relevant experience for Ph.D., 11+ years for M.S./M.A., or 14+ years for B.S./B.A.&nbsp; 8+ years of experience in data and/or knowledge management, with minimum 3 years in a life sciences or biotech setting. Proven experience leading enterprise data governance and knowledge sharing initiatives in a highly regulated environment. Strong project management and communication skills; able to work cross-functionally with scientific and operational teams. Experience with tools like SharePoint, Veeva Vault, Confluence, Tableau, and SQL is highly desirable. Experience supporting clinical trials and regulatory submissions (e.g., IND, BLA) strongly preferred. Background in immunology, vaccines, or infectious disease R&amp;D is highly preferred. Experience in scaling systems and processes in a high-growth, early- to mid-stage biotech company is preferred. Reports to: Sr. Director, Process Validation &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $208,000 – $243,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for any relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director of Data and Knowledge Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: As we grow, we are seeking a strategic and collaborative&nbsp;Associate Director, Regulatory Support for Global ASAT (Analytical Sciences and Technology)&nbsp;to manage and support all activities associated with the analytical aspects of regulatory CMC related support. The Associate Director, Regulatory Support will manage the timelines and deliverables to ensure submission requests are aligned with project milestones, and ensure that all the sections are complete, well-written, and meet all relevant requirements. This role is instrumental in ensuring scientific data integrity, regulatory readiness, and the preservation of institutional knowledge in a dynamic, fast-paced clinical environment. Essential Functions: Plan and prepare analytical sections for global regulatory CMC-related content pertaining to Marketing Application (new and renewals), Post-approval Variations, and periodic reports for North America and International markets in accordance with the developed regulatory strategy. Collaborate and align with Reg CMC Product Lead regarding change record assessments of proposed analytical changes and regulatory strategy, provide regulatory guidance for support of implementation to cross-functional stakeholders. Ensure required analytical regulatory documents for submissions are complete, accurate, and meet relevant requirements. Manage the timelines and deliverables to ensure analytical submissions are aligned with program milestones and assure that regulatory query timelines are met. Proactively identify issues and escalate to Global Analytical and Reg CMC Product Lead. Develop relationships with Analytical Development, QC, Regulatory Affairs, Technical Development, Sites (internal and external), and Quality to support submission preparation. Process documentation requests for ASAT to support key application activities and queries. Assist with data/documentation gathering for regulatory authority (FDA, Health Canada) interactions for assigned projects such as pre-Agency meeting requests, briefing packages. Managing and/or assisting in responding to country health authority queries. Work in Regulatory and Quality databases via Veeva platform. Requirements:&nbsp; Degree(s) in Life Sciences, Data Science, Information Management, or related discipline with a minimum of 9+ years of relevant experience for Ph.D., 11+ years for M.S./M.A., or 14+ years for B.S./B.A. Other combinations of education and/or experience may be considered. Proven experience leading enterprise data governance and knowledge sharing initiatives in a highly regulated environment. Strong project management and communication skills; able to work cross-functionally with scientific and operational teams. Experience with tools like LIMS, SharePoint, Veeva Vault, Confluence, Tableau, and SQL is highly desirable. Experience supporting clinical trials and regulatory submissions (e.g., IND, BLA) preferred. Background in immunology, vaccines, or infectious disease R&amp;D preferred. Experience in scaling systems and processes in a high-growth, early- to mid-stage biotech company preferred. Reports to: Senior Director, Global Analytical Sciences and Technology (ASAT) Lead &nbsp; Location: San Carlos, CA; Open to remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $173,000 - $201,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Regulatory Support for Global ASAT

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking an experienced Data Systems Engineer to lead the design, implementation, and support of Laboratory data management systems at Vaxcyte. The ideal candidate will have a strong background in deploying lab data systems used in the Biotech industry, coordinating cross-functional teams, and ensuring compliance with relevant industry standards. This role is essential in enhancing laboratory workflows, ensuring data integrity, and improving operational efficiency across scientific domains. Essential Functions: Act as the Systems Lead and Administrator for Vaxcyte’s Benchling ELN to manage user accounts, permissions, and system configurations in alignment with organizational needs. Lead implementation of data system business process mapping and requirements gathering. Create detailed lifecycle documentation for Benchling and other lab data systems. Troubleshoot and resolve technical issues in collaboration with IT and end users. Oversee cross-functional projects, ensuring lab data systems are integrated seamlessly with existing IT systems and aligned with business needs. Provide technical support and training, ensuring optimal end-user experience. Partner with scientists to assess pain points and design improvements in Benchling workflows, schemas, and templates to optimize system performance. Implement new features and modules to support evolving operational processes while maintaining technical documentation. Contribute to data governance by establishing best practices. Maintain vendor relationship to stay updated on product developments, raise ongoing technical challenges, and influence product roadmap priorities. Requirements:&nbsp; Bachelor's degree in Computer Science, Information Systems, or Engineering with a minimum of 5 years of hands-on experience configuring and administering Laboratory Information Management Systems (LIMS), Electronic Lab Notebooks (ELN) or similar Other combinations of education and/or experience may be considered. Hands on experience with Benchling configuration, administration, and/or integrations. Experience gathering user requirements and translating them into technical deliverables. Proficiency in master data management and workflow optimization within lab data. Excellent communication, interpersonal, and training skills, with experience in leading end-user training and support. Ability to translate technical concepts for non-technical end users. Knowledge of data structures and relational database Knowledge of SQL and experience with data interfaces and integrations within lab data. Knowledge of programming languages such as Python. Previous experience in Biotech, pharma, or life science research environment. Familiarity with laboratory workflows: R&amp;D and CMC. Reports to:&nbsp;Data Systems Manager, LIMS &amp; ELN &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $138,000 - $161,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Data Systems Engineer

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director of IT SAP Systems is a key leadership role responsible for the successful planning, delivery and ongoing management of Vaxcyte’s SAP and Advanced Planning &amp; Scheduling (APS) initiatives. This individual will oversee and manage the implementation of our upcoming SAP Enterprise Resource Planning (ERP) and OMP Advanced Planning Systems (APS). This position requires a strategic thinker with a high level of expertise in SAP and APS systems. They will provide team leadership to ensure that business goals and objectives are met efficiently and effectively. This is a collaborative hands-on role working closely with business partners and subject matter experts from supply chain, finance and other business teams to deliver ERP/APS solutions that will support our growth through vaccine commercialization and beyond. The position reports to the Sr Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters. Essential Functions: Lead and execute SAP and OMP implementations and subsequent projects ensuring alignment with organizational objectives and strategic goals. Deep experience collaborating with stakeholders to understand their requirements, manage expectations, and provide regular project updates. Vendor collaboration, budget planning, preparing for and facilitating steering committee meetings. Identify, assess, and mitigate project risks to minimize potential impact on project outcomes. Implement change management processes for SAP and APS to ensure smooth transitions and adoption of new systems and processes. In addition, develop support for tracking GxP and SOX related changes. Monitor project performance using appropriate systems, tools, and techniques, and implement corrective actions as needed. Create and curate program standards including tools, deliverables and document management. Promote a culture of continuous improvement by identifying areas for enhancement and implementing best practices in SAP and APS through initial implementation and lifecycle management. Lead a cross functional team from the business, IT, consultants, contract manufacturer resources, and other professionals to achieve high performance and project success. Requirements:&nbsp; Bachelor’s degree in Information Technology, Business Administration, or a related field. A master’s degree or relevant certifications (e.g., PMP, SAP certification) is desired. At least 12 years of experience in program/project management, with multiple SAP and APS system implementations. Other combinations of education and/or experience may be considered. Experience leading large and complex initiatives, including development of detailed timelines, milestone creation, and resource requirements to ensure timeline execution and delivery. In-depth knowledge of SAP systems, including SAP S/4HANA and integration techniques. Experience implementing APS systems (OMP experience is desired). Experience delivering large scale SAP projects. Expertise with agile methodology, global deployments and data migration planning. Leadership: Strong leadership and team management skills, with the ability to motivate and guide cross-functional teams. Excellent verbal and written communication skills, with the ability to effectively communicate complex technical concepts to non-technical stakeholders. Strong background implementing and maintaining GxP validated and SOX regulated systems Strong analytical and problem-solving skills, with the ability to identify issues and implement effective solutions. Experience in identifying and managing project risks, with a proactive approach to mitigation. Proficiency in change management principles and techniques to facilitate smooth transitions and adoption of new systems. Experience with biotech/pharma companies both pre and post commercialization. Reports to:&nbsp;Senior Director, Enterprise IT Systems &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $226,000 - $264,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, IT SAP Systems

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director, IT Supply Chain Systems is a key leadership role responsible for the successful delivery and management of Vaxcyte’s Supply Chain systems projects and programs. This individual will support the Supply Chain team with the implementation of our SAP ERP system and our OMP Advanced Planning System (APS). This position requires expertise in SAP and APS systems, and project management. This role will be a hands-on technical role and will provide team management and leadership for IT Supply Chain systems and ensure that business goals and objectives are met efficiently and effectively. This is a collaborative role working closely with the Supply Chain team to deliver a system that will support Vaxcyte’s growth through commercialization. Essential Functions: Lead, mentor, develop and manage the IT supply chain systems team, fostering a culture of collaboration, accountability and continuous improvement. Develop and manage the IT supply chain systems roadmap and budget, ensuring resources are allocated effectively and efficiently. Program Management: Provide IT leadership for supply chain portions of SAP implementation ensuring alignment with organizational objectives and strategic goals. Plan and lead IT OMP implementations and subsequent upgrades and enhancements. Program Planning and Execution: Develop detailed project plans, including timelines, milestones, and resource allocation, and ensure timely execution and delivery of supply chain systems. Performance Monitoring: Monitor system and project performance using appropriate systems, tools, and techniques, and implement corrective actions as needed. Continuous Improvement: Promote a culture of continuous improvement by identifying areas for enhancement and implementing best practices in SAP and APS program management. Requirements:&nbsp; Bachelor’s degree in Information Technology, Business Administration, or a related field. A master’s degree or relevant certifications (e.g., SAP certification) is desired. A minimum of 12 years’ experience supporting supply chain systems, with multiple SAP and APS system implementations. Other combinations of education and/or experience may be considered. Stakeholder Engagement: Extensive experience collaborating with stakeholders to understand their requirements, manage expectations, and provide regular project updates. Extensive knowledge of supply chain, procurement, manufacturing and quality systems and regulatory processes. Plan to deliver E2E Process experience including demand and supply planning, CMO scheduling and manufacturing, logistics, direct procurement, and quality release. In-depth knowledge of SAP systems, including SAP S/4HANA and integration techniques. Deep experience implementing APS systems (OMP experience strongly desired). Project Management: Proven experience in managing supply chain projects, including planning, execution, and delivery. Expertise with system integrations with internal and external systems Strong leadership and team management skills, with the ability to motivate and guide cross-functional teams. Communication: Excellent verbal and written communication skills, with the ability to effectively communicate complex technical concepts to non-technical stakeholders and to communicate with internal business partners and external parties (e.g. contract manufacturers) Problem-Solving: Strong analytical and problem-solving skills, with the ability to identify issues and implement effective solutions. Experience managing GxP validation systems and the processes required to manage and maintain validation. Experience with biotech/pharma companies both pre and post commercialization. International travel may be required up to 15%. Reports to:&nbsp;Senior Director, Enterprise IT Systems &nbsp; Location:&nbsp;San Carlos &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $225,000 - $263,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, IT Supply Chain Systems

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.At Vaxcyte, we are always looking for bright, committed, and innovative people who are passionate about making a difference. &nbsp; If you do not see an opportunity on our Careers Page that is a good match with your background, please submit your resume to be part of our Talent Community to be considered for future opportunities. &nbsp; We also encourage you to regularly visit our Careers Page as we continue to grow and add more opportunities.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Don't see a role you're looking for? Please submit your resume for future consideration

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly skilled Manager, Quality Systems to ensure adherence to regulatory standards, continuous improvement, and operational excellence within our organization. The ideal candidate will have experience in quality management systems (QMS), a background in regulatory requirements, and experience successfully validating, implementing, and maintaining quality systems in a regulated industry. Essential Functions: Assist with development and maintenance of the company's Quality Management System (QMS) in accordance with company procedures and regulatory requirements (e.g., 21CFR Part 11). Assist with driving continuous improvement initiatives that relate to QMS to enhance quality, efficiency, and compliance across all departments. Collaborate cross-functionally with IT, and other departments to ensure alignment of quality objectives and initiatives. Strive to foster a culture of quality and continuous improvement. Assist with preparation for and participate in regulatory inspections and customer audits, ensuring readiness and compliance. Ensure alignment with department management and company vision. Promote a quality mindset and quality excellence approach to all activities. Complete other responsibilities, as appropriate. Requirements:&nbsp; Bachelor's degree in a relevant scientific discipline. Minimum of 5 years of experience in quality management within a regulated industry (e.g., medical devices, pharmaceuticals, biotechnology). Demonstrate knowledge of GXP regulations and guidelines as it pertains to Quality Systems. Experience in assisting with the validation, implementation, and managing Quality Management Systems (QMS) compliant with FDA regulations (e.g., 21 CFR Part 820), and other relevant regulatory requirements. Experience driving cross-functional collaboration. Excellent analytical and problem-solving abilities, with a keen attention to detail. Experience with Veeva QMS required. Knowledge or experience with Computer System Validation and/or Computer Software Assurance highly desirable. Experience with test script execution, a plus. Ability to work in a collaborative team environment. Reports to: Associate Director, Quality Systems &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Expected Contract Length: 6-7 months &nbsp; Hourly Range: $70.00 - $78.00 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Systems (contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.&nbsp; Summary: Vaxcyte is looking for a talented Document Specialist, who will be responsible for managing manufacturing documents in a GXP compliant environment. This includes, but is not limited to, batch records, specifications, and memos. The role is focused on maintaining documentation in the Quality Systems associated with the manufacturing and testing of our vaccines and preparing for future clinical trials. Essential Functions: Maintenance of the Quality Systems documentation in Veeva (electronic document control system) and other electronic systems where required. Perform document specialist functions in QA, including managing the lifecycle of GMP documents in Veeva, including creation, revision, approval, distribution and archival, ensuring compliance with internal procedures and regulatory standards. Work closely with quality assurance, external vendors, functional areas and Project Management team for daily management of routing, revisions, approval, and filing of documents within defined timelines. Organize and ensure accurate and reliable filing systems for all electronic and paper-based GMP documents. Support audits as appropriate (internal and regulatory). Requirements:&nbsp; Bachelor’s BA/BS degree or equivalent experience and minimum of 2 years of biopharmaceutical industry experience. Other combinations of education and/or experience may be considered. Experience with managing key Quality Management System processes (e.g., Document Control, Change Management, Training). 2+ years of experience with document management utilizing EDMS systems, Experience with Veeva QualityDocs preferred. Familiarity with documents and records associated with GxP manufacturing and testing activities. Understanding of current regulatory expectations including 21CFR Part 11 requirements. Demonstrated ability to collaborate and influence across organization to gain support and commitment for team goals; effective management of groups of professionals to achieve desired results. Strong professional interpersonal and communications skills, both verbal and written, to provide clear direction for the business, vendors, and internal stakeholders. Strong attention to detail, organizational skills, ability to work in a faced paced environment. Ability to meet deadlines and multi-task efficiently. Working knowledge with SmartSheet, Microsoft Office Suite, Word, Excel, PowerPoint, Visio, and Adobe. Reports to: Senior QA Document Specialist &nbsp; Location: San Carlos, CA; Hybrid &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $89,000 – $103,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

QA Document Specialist II

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is looking for a Senior Associate Scientist (contract) with experience in microbial fermentation and upstream processing to join the Upstream Polysaccharide Process Development team. The candidate will be responsible for collaboration on experimental design and execution of experiments to further develop and optimize upstream processes for polysaccharide manufacturing using microorganisms. The successful candidate will have practical laboratory experience related to microbial fermentation processes and eager to utilize and learn new laboratory skills. The role will require &gt;50% time in the lab and this person will be able to independently detail experimental procedures/results in written and presentation formats. The successful candidate may interface closely with the cross-functional team, write detailed technical reports, present experimental results internally, and may potentially interface with external CMO partners. Essential Functions: Support in study design, execute, and analyze experiments for upstream polysaccharide for bacterial fermentation (BSL2) and vaccine production processes. Execute experiments to develop the upstream process parameters (e.g., media, feed, pH, temperature, dissolved oxygen, agitation, etc.) and to enhance product yield, quality, and consistency. Perform microbiology related work including plating, colony selection, Gram staining and cell enumeration on microscope. Perform fermentation vessel assembly and script writing for process automation and execute fermentation experiment in shake-flask and lab scale bioreactors. Prepare media and buffer as needed for experiments. Operate and maintain instrumentation for bacterial fermentation and primary recovery (centrifugation, filtration, etc.) of bacterial polysaccharides utilizing aseptic techniques. Support analytical method execution including optical density, residual metabolites and polysaccharide concentration and other relevant analytical techniques. Assist in executing late-stage process development studies including process characterization. Keep accurate and current records of research and/or project related activities in laboratory notebooks and Electronic Lab Notebook. Prepare and review protocol, technical reports, SOPs, and batch records. Present and communicate scientific data and results to internal stakeholders. Be an outstanding teammate and collaborate effectively with downstream, analytical, and manufacturing teams within Polysaccharide Development and Manufacturing team to ensure seamless technology transfer and process integration. Requirements:&nbsp; MSc in Chemical/Biochemical Engineering, Biotechnology, or similar degree with a minimum of 3 years of relevant industry experience, or BSc with a minimum of 5 years of relevant industry experience. Experience in handling microorganisms with proper aseptic techniques to perform upstream processing related work in flasks/bioreactors. Hands-on experience and theoretical understanding of key processing operations such as microbial culture, fermentation process, microbial media, and process optimization and relevant analytical technologies; experience with depth filtration, continuous centrifugation is a plus. Develop and optimize scripts for instrumentation, including Ambr® systems, to enhance efficiency and automate processes, leveraging programming languages such as Python or R is a plus. Experience with Design of Experiments (DoE) principles and DoE software. Process characterization experience is a plus. Cell banking expertise, colony selection and genetic analysis of recombinant strains is a plus. Proficiency with computer programs such as Microsoft Excel, Word, PowerPoint, Visio and JMP. Working knowledge of GMP requirements. Proven ability to succeed in a cross-functional team environment, effectively managing multiple projects and contributing to team outcomes. Strong interpersonal skills, with excellent written and verbal communication abilities. Reports to: Sr. Scientist, Upstream Polysaccharide Process Development &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12months &nbsp; Hourly Range: $54/hr. - $60/hr. &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist (contract), Upstream Polysaccharide Process Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: As Vaxcyte’s products progress towards late stage and commercialization, we are looking for people with experience in Quality Control for late stage or commercial products to strengthen our global Quality Control team. Within that Quality Control Organization, we are seeking a Senior Manager Quality Control acting as single point of contact for our CDMO in Europe. The Senior Manager QC will represent the executive function of QC ensuring analytical strategies are implemented at our CDMO and/or external testing lab to ensure the quality, accuracy, and compliance of testing and analytical services. Working closely with the analytical technical lead and other functions within Analytics, Process Development, Quality Assurance, Operations, and Regulatory functions, this role is accountable that testing and release is performed at our CDMO in a timely and compliant manner to ensure secure and uninterrupted supply of Vaxcyte’s innovative therapies. Essential Functions: Implement the analytical control strategy for our programs at our CDMO/contract labs and ensure they are aligned with the CDMO's goals and objectives as well as comply with relevant regulations and industry standards. Implement, and maintain robust quality control systems that encompass sampling, testing, documentation, and release procedures. Ensure on-time performance for QC testing at our CDMO’s or contract laboratories related to raw materials, intermediates, and drug substance Ensure that contracted QC laboratories are equipped with appropriate instrumentation and equipment, maintained according to regulatory requirements, and calibrated regularly to ensure accuracy and reliability of test results. In partnership with analytical technical lead and analytical science and technology as well as the contract laboratories, oversee method validation and transfer activities between contract laboratories. Assure that appropriate systems for data management, including secure storage, retrieval, and retention of QC data and documentation are in place. Ensure that all testing activities are well-documented and comply with Good Documentation Practices (GDP). Review and approval of analytical data, test reports, and certificates of analysis (CoAs) generated by contract laboratories to verify accuracy, completeness, and compliance with specifications for both release and stability testing. Support investigations and deviations, out-of-specification (OOS), out-of-trend (OOT), out-of-expectation (OOE) results, laboratory incidents, and customer complaints related to contract laboratory testing, collaborating with contract laboratories and internal stakeholders to implement corrective and preventive actions (CAPAs). Provide technical support for product related inspections by Health Authorities. Writing, review and approval of documents related to Quality Control to ensure compliance with applicable regulatory and industry standards. Requirements:&nbsp; Bachelor of Science with 8+ years of relevant experience in biotechnology/pharmaceutical industry. Experience in Pneumococcal vaccines is a plus. Excellent experience in managing CDMOs and/or contract laboratories. Comprehensive knowledge in cGMP and experience in multi-national regulations. Excellent communication, negotiation, and relationship-building skills, with the ability to collaborate effectively with internal and external stakeholders. Strong analytical and problem-solving abilities, with a focus on data-driven decision-making and continuous improvement. Strong teamwork and interpersonal skills. Relentless focus and passion around process improvements (efficiency and automation). Reports to: Head of Quality Control &nbsp; Location:&nbsp;Visp, Switzerland &nbsp; Compensation: The compensation package will be competitive and includes an equity component. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Control

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: As Vaxcyte’s products progress towards late stage and commercialization, we are looking for people with experience in Quality Control for late stage or commercial products to strengthen our global Quality Control team. Within that Quality Control Organization, we are seeking a Senior Manager, Quality Control acting as single point of contact for our CDMO in Europe. The Senior Manager QC will represent the executive function of QC ensuring analytical strategies are implemented at our CDMO and/or external testing lab to ensure the quality, accuracy, and compliance of testing and analytical services. Working closely with the analytical technical lead and other functions within Analytics, Process Development, Quality Assurance, Operations, and Regulatory functions, this role is accountable that testing and release is performed at our CDMO in a timely and compliant manner to ensure secure and uninterrupted supply of Vaxcyte’s innovative therapies.&nbsp; Essential Functions: Implement the analytical control strategy for our programs at our CDMO/contract labs and ensure they are aligned with the CDMO's goals and objectives as well as comply with relevant regulations and industry standards. Implement, and maintain robust quality control systems that encompass sampling, testing, documentation, and release procedures. Ensure on-time performance for QC testing at our CDMO’s or contract laboratories related to raw materials, intermediates, and drug substance Ensure that contracted QC laboratories are equipped with appropriate instrumentation and equipment, maintained according to regulatory requirements, and calibrated regularly to ensure accuracy and reliability of test results. In partnership with analytical technical lead and analytical science and technology as well as the contract laboratories, oversee method validation and transfer activities between contract laboratories. Assure that appropriate systems for data management, including secure storage, retrieval, and retention of QC data and documentation are in place. Ensure that all testing activities are well-documented and comply with Good Documentation Practices (GDP). Review and approval of analytical data, test reports, and certificates of analysis (CoAs) generated by contract laboratories to verify accuracy, completeness, and compliance with specifications for both release and stability testing. Support investigations and deviations, out-of-specification (OOS), out-of-trend (OOT), out-of-expectation (OOE) results, laboratory incidents, and customer complaints related to contract laboratory testing, collaborating with contract laboratories and internal stakeholders to implement corrective and preventive actions (CAPAs). Provide technical support for product related inspections by Health Authorities. Writing, review and approval of documents related to Quality Control to ensure compliance with applicable regulatory and industry standards. Requirements:&nbsp; Bachelor of Science with minimum 9 years of relevant experience in biotechnology/pharmaceutical industry. Experience in Pneumococcal vaccines is a plus. Excellent experience in managing CDMOs and/or contract laboratories. Comprehensive knowledge in cGMP and experience in multi-national regulations. Excellent communication, negotiation, and relationship-building skills, with the ability to collaborate effectively with internal and external stakeholders. Strong analytical and problem-solving abilities, with a focus on data-driven decision-making and continuous improvement. Strong teamwork and interpersonal skills Relentless focus and passion around process improvements (efficiency and automation). Reports to: Head of Quality Control&nbsp; &nbsp; Location: Visp, Switzerland&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes an equity component. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join Vaxcyte’s Vaccine Product Development organization as a Stability Manager within the Quality Control Unit. The primary function of this level position is to manage the stability program for various projects in preclinical and clinical development.&nbsp; The position will be an integral part of the team implementing and maintaining cGMP Stability for all phases of clinical development. Primary responsibility will include managing stability studies for individual projects and stability data analysis. This individual will collaborate with QC members in a highly collaborative and cross-functional environment. The ideal candidate will apply strong stability experience, ensure compliant operations and documentation, foster open communication, and pursue data-driven approaches. Essential Functions: Designs, coordinate, and execute stability studies for early and late-stage vaccine products according to regulatory guidelines and company protocols. Summarize vaccine stability results by applying analytical testing expertise to ensure scientific and technical excellence. Utilize statistical software like JMP to perform rigorous statistical analyses, ensuring robust interpretation of data and adherence to regulatory standards. This includes, but not limited to, creating, implementing, and managing stability databases, performing data trending and statistical analysis, study and testing forecasting and reporting of metrics, creation, revision and approval of SOP's, stability protocols and reports in accordance with current GMP, FDA, EU, Global and ICH guidelines and regulations. Produce impactful PowerPoint presentations to effectively communicate stability data to diverse project team members. Support the attainment of project milestones by facilitating stability monitoring and determining expiration dates for clinical and in-process materials. Authors, reviews, revises, and approves SOP's, stability protocols and reports, memo’s, regulatory and specification documents (as required). The Stability Manager will also assist with leading the functionality and maintenance of stability related processes and systems. Drives continuous improvement activities for the clinical stability programs. Ensures that the GMP stability program continuously aligns with FDA, ICH and other international agencies. Manages Quality Systems records for QC Stability- creates, assesses, reviews Deviations, Change Controls, CAPA's and other applicable stability-related investigations and events. Guide and work with others to identify opportunities for continuous improvement and implement/maintain solutions. Provide strong teamwork in establishing a quality culture and shared accountability. Ensure GMP compliance is built into the design and implementation of processes and systems, including tracking metrics to monitor and improve performance. Requirements: MS or BS with minimum of 8 years of industry experience in Pharma / Biotech industry required. Other combinations of education and/or experience may be considered. Strong understanding of vaccine stability principles, including degradation pathways, accelerated stability testing, and shelf-life determination. Demonstrated proficiency and expertise in various analytical methodologies, particularly in the context of stability testing and assessment of biologics or vaccines. Solid understanding of relevant FDA, EU, and ICH regulatory guidelines and pharmacopeia as applicable to stability study design, expiry dating, and analytical method qualification/validation for biologics and vaccines. Solid understanding and hands-on experience of applying basic statistical tools for stability data trending and rate analysis to support retest period/ shelf-life proposals. Attention to detail and excellent skills in record keeping / documentation. Experience in IND, NDA and BLA submission is highly preferred. Experience working in a regulated (GLP / GMP) environment. Extensive technical writing experience. Strong interpersonal skills; ability to communicate effectively both verbally and in written formats. Solid understanding of product development activities in biotech/drug/vaccine development, including key interdependencies, and knowledge of proven development strategies and tactics. Ability to work globally with CMOs in different countries and continents. Reports to: Director, Stability Location: San Carlos, CA Compensation: &nbsp;The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $147,000 – $171,000 *(SF Bay Area). Salary ranges for non-California locations may vary.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Stability Manager

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: Vaxcyte is looking for an energetic and talented Sr. Engineer to contribute to the Polysaccharide development and manufacturing group within the CMC team. Vaxcyte is developing a multi-valent polysaccharide-based conjugate vaccine, based on a novel carrier protein produced using the Xpress CF platform. Polysaccharides are a critical component in conjugate vaccines.The successful candidate will have extensive experience in downstream purification early-stage development and late-stage process characterization. The candidate will have a strong understanding of DOE experimental design, execution, and analysis with statistical software (e.g. JMP). The candidate has demonstrated leadership on a project initiative and/or management of a team. The candidate will be eager to utilize and learn new laboratory skills as this person will be responsible for collaboration on experimental design and execution of experiments to further the polysaccharide development and manufacturing programs. This position will require &gt; 50% time in the lab and this person will be able to independently detail experimental procedures/results in written and presentation formats. The successful candidate will interface closely with the CMC team, write detailed technical reports, present experimental results internally, and interface with external CMO partners. &nbsp; Essential Functions: Design and execute experiments to further develop downstream processes including: Continuous centrifugation and depth filtration development TFF optimization and characterization Chromatography screening, optimization, and characterization Scaling studies Development of scale-down model for unit operations Lead initiatives and tasks for downstream process characterization studies. Operate and maintain instrumentation for polysaccharide purification including automated TFF systems, Akta chromatography skids, automated filtration units and continuous centrifuges. Perform analysis and interpret results for polysaccharide and impurity assays (Anthrone, Lowry, SEC-MALS, HPAEC-PAD). Keep accurate and current records of development experiments and/or project related activities in laboratory notebooks or electronic notebook, prepare technical reports, summaries of testing, and detailed protocols. Present/communicate data to polysaccharide team as well as cross-functional teams. Research literature to identify novel methodologies and solve scientific problems which apply to the overall program. Review executed protocols and batch records and support tech transfer purification processes to external manufacturing groups. Writes, reviews, and approves R&amp;D protocols, batch records, and reports in support of process development, and assay development. May have direct reports in the future. Works within a team environment and provides support as necessary to further the team’s initiatives. Requirements:&nbsp; PhD in Bioprocess Engineering, Chemical Engineering, Biotechnology, or a related discipline, with a minimum of 5 years of industry experience or combination of industry and postdoctoral research; M.S. with a minimum of 10 years of industry experience; or B.S. with a minimum of 13 years of industry experience. Strong understanding of the principals of DOE (Design of Experiments); practical experience with DOE software; proficient in the design and interpretation of statistically modelled experiments. In-depth late-stage process characterization development experience (Risks assessments, CPP Identification, PAR, PC study report writing). Practical experience with and theoretical knowledge of traditional processing unit operations including TFF, depth filtration, continuous centrifugation, and chromatography. Demonstrated leadership on a project initiative and/or management of a team. Has successfully worked in a cross-functional team environment on multiple projects; ability to work effectively as a member of a team to deliver results. Proficient with engineering principles involved in scaling processes from lab to pilot scale as well as developing a scale-down model. Proficient with computer programs such as JMP, Microsoft Excel, Word, PowerPoint, Visio. Working knowledge of the requirements of GMPs. Experience working with CDMOs and ability to effectively communicate experimental design and results to a CDMO. Technical knowledge and experience using Tecan Fluent instrumentation and generating scripts for high throughput screening application is a plus Ability to travel internationally to a CMO as some international travel may be required. Strong interpersonal skills, with excellent written and verbal communication skills. Prior experience in polysaccharide development is a plus. Reports to: Director, Downstream Polysaccharide Development and Manufacturing &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $157,000 – $183,000&nbsp; &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Engineer, Polysaccharide Downstream Process Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our Drug Product Development team. The candidate must have knowledge of and practical experience in analyzing and characterizing biomolecules (proteins, polysaccharide conjugates, vaccines) using a variety of methods, including immunoassays, chromatography, spectrophotometric techniques, light scattering, and particle sizing. Experience in analyzing vaccine and adjuvant-containing formulations is a plus. In addition, Vaxcyte is looking for an experienced and flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a lab-based scientific role and requires excellent scientific judgement, independence, rigor, and thorough record-keeping. Essential Functions: Routine and non-routine analysis of internal release, development, and stability samples and reporting of data using multiple analytical techniques across the Drug Product working groups. Executing non-GxP stability study analysis for thermal, freeze/thaw, and agitation as well as container closure system evaluation for both Drug Substance and adjuvanted vaccine Drug Product materials. Support the Vaxcyte PCV (and other projects), external analytical, and manufacturing CMOs to enable tech transfer and implementation of processes and analytical methods. Vaxcyte is looking for a flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a scientific role, which is predominantly lab-based, requiring excellent scientific judgement, independence, rigor, and thorough record-keeping. Requirements:&nbsp; MSc with 1 year of experience, or a BSc with a minimum of 2 years of experience the in pharmaceuticals and or biotechnology industries. Chemistry, Biophysics or Biochemistry preferred. The candidate will preferably have established practical experience in the analytical characterization of large biomolecular Drug Products in pre-filled syringes and vials. Experience executing bioanalytical components of product release testing and long-term stability studies, including biochemical, biophysical, and compendial methods. Experience in plate-based assays (high-throughput screening, ELISA, etc), multiplexed immunoassay (MSD, Luminex, etc.), compendial methods (osmolality, pH, etc), and spectrometric methodologies. Experience in authoring analytical technical documents, including method protocols, SOPs, and reports, as well as experience recording and templating electronic laboratory notebooks (eLN). The candidate should have high degrees of both flexibility and organizational skills as well as an eagerness and ability to learn, to effectively navigate Vaxcyte’s multiple projects and timelines. Strong interpersonal skills; ability to communicate effectively both verbally and in written formats are necessary to collaborate effectively with the rest of the Formulation and Drug Product Development team, as well as train other analysts and team members. Detail-oriented, rigorous, and excellent skills in record keeping. Reports to: Senior Manager, Drug Product Analytics &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12months&nbsp; Hourly Range: $48.00 - $54.00 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II (contract), Drug Product Analytics

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an experienced candidate to support implementation of our OMP Advanced Planning (APS), SAP Enterprise Resource Planning (ERP) and future Supply Chain systems, as part of our Commercial Manufacturing and Supply Chain (CMSC) organization.&nbsp; This is a business role, not an IT role.&nbsp; It is focused on process definition, systems design, and integration of the Supply Chain Management, Procurement, Logistics, Manufacturing, AD/QC, and Quality business functions at Vaxcyte.&nbsp; The candidate will work closely with the Director, Supply Chain Systems to implement the Plan to Deliver and Direct Procure to Pay workstreams. Essential Functions: Project Management:&nbsp; Partner with project managers to develop detailed project plans. Coordinate and lead cross functional teams to ensure successful project execution per the project plans.&nbsp; Monitor progress, manage schedule, issues and risks, and provide status updates. APS and ERP Design and Implementation: Support the end-to-end design and implementation of SAP&nbsp; and OMP for the Supply Chain Management, Procurement, Manufacturing, AD/QC and Quality business functions. Develop and align integrated business processes for the above functions, incorporating best practices and industry standards while adhering to compliance standards and regulatory requirements. Stakeholder Management: Serve as the primary Vaxcyte Switzerland contact for the OMP and SAP implementation projects. Communicate effectively with all internal and external stakeholders and project team members including business partners, software vendors, and integrators.&nbsp; Facilitate team meetings to keep stakeholders engaged and informed. Escalate appropriately to senior management for awareness and decision making. Resource Management: Identify resources and skills necessary to complete project activities and meet project goals.&nbsp; Coordinate with department managers to secure necessary resources and support.&nbsp; Monitor resource allocation and develop contingency plans to address resource constraints. Business Training and Support: Develop and deliver training programs to ensure end user adoption of business processes and systems.&nbsp; Develop and maintain training documentation including policies, standard operation procedures (SOPs), and work instructions.&nbsp; Performance Management and Optimization: Work with global process owners and key stakeholders to align key performance indicators (KPIs). Monitor performance, analyze data, and identify areas for optimization. Drive continuous improvement through iterative enhancements. Master Data Management: Support the governance of master data for supply chain systems.&nbsp; Lead the creation, maintenance and quality control of master data.&nbsp; Ensure data is aligned with business needs and meets regulatory requirements.&nbsp; Design and implement the data management end-to-end process and data quality and accuracy KPIs. Process and systems continuous improvement:&nbsp; Lead process and system improvements, enhancements, and upgrades to scale Vaxcyte’s capabilities and integration with our primary Switzerland-based CMO. Secure business resources to support initiatives. Ensure end-user support and troubleshooting are provided post implementation and verify new functionalities are properly rolled out and intended benefits are achieved. SAP and OMP EU Business Systems Owner: Ensure systems are maintained in compliance with changing and/or new regulatory and validation requirements.&nbsp; With IT, maintain validation documentation and ensure the systems operate in a state of control.&nbsp; Work closely with quality assurance to comply with industry standards and regulatory guidelines Requirements:&nbsp; S. / B.A. degree or Advanced Degree (preferred). 8+ years of experience working in commercial pharmaceutical / biotech companies with a focus on APS/ERP implementations Has completed multiple SAP S/4 HANA lifecycle systems implementations in similar roles PMP or similar project management certification and proficient in project management tools (e.g. MS Project and Smartsheet) Strong experience working with CMOs, Software Vendors and Integrators In-depth knowledge of GMPs, FDA regulations and biotech industry standards Strong experience leading cross-functional teams Proficient in change management methodologies (e.g. Prosci ADKAR, Kotter’s Change Model) or demonstrated experience in leading change management initiatives Design and implementation expertise in APS and ERP systems with a proven track record of managing and delivering fast-track projects successfully Comprehensive knowledge of Supply Chain, Procurement, Manufacturing, Quality and Regulatory processes Experience with systems validation processes, including developing and executing validation plans to ensure compliance with regulatory requirements Experience with Lean, Six-Sigma or other process improvement methodologies Strong communication, problem-solving, analytical and decision-making skills Reports to: Director, Supply Chain Europe &nbsp; Location: Switzerland: Visp, VS or Steinhausen, ZG &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp; We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Supply Chain Systems

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: At Vaxcyte, we’re on a mission to protect humankind from the consequences of bacterial diseases through the development of high-fidelity vaccines. As we grow, we are looking for a Talent Acquisition Coordinator to join our collaborative, fast-moving Talent Acquisition team. This is a high-impact, hybrid role for someone who thrives on creating exceptional candidate experiences and has a sharp eye for operational efficiency. You will own critical parts of the interview coordination process, support recruiting projects across departments, and gain exposure to both recruiting and recruiting operations. At the start, this position will be 20-30 hours per week and may flex up to 40 hours a week depending on business needs. If you are passionate about building great teams, have a systems mindset, and love solving problems before they arise, we would love to meet you. Essential Functions: Partner with Recruiters and hiring teams to deliver an exceptional, high-touch candidate experience from first contact through offer. Own interview scheduling (onsite and virtual) for roles across all levels, including executive-level coordination. Manage recruiting calendars, Zoom logistics, and conference room bookings; greet candidates onsite and ensure a welcoming experience. Coordinate candidate travel and process reimbursements. Collaborate with Executive Assistants and Hiring Managers to streamline scheduling and resolve conflicts proactively. Support job posting and description creation across multiple departments. Manage contractor POs and SOWs in IronClad and NetSuite. Maintain the highest level of professionalism, confidentiality, and candidate care. Assist with other projects/assignments as assigned to support Talent Acquisition Operations or other initiatives. Requirements: Bachelor’s degree or equivalent experience. 1-3+ years in an administrative, coordination, or recruiting support role (experience as a Talent Acquisition Coordinator strongly preferred). Experience using Greenhouse or another modern ATS. Excellent communication skills—written, verbal, and interpersonal—with the ability to interact confidently with all levels, including senior executives. High attention to detail, time management, and organizational skills. Problem-solver who stays calm under pressure and can juggle competing priorities. Empathy and a strong customer service mindset—must advocate for a great experience for all stakeholders. A collaborative and growth-oriented mindset. Ability to think in systems and create repeatable, efficient workflows. Reports to: Sr. Recruiter, Talent Acquisition Location: San Carlos, CA; Hybrid (2-3 days/week) Expected Contract Length: 12 months Hourly Range: $37.00- $41.00 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Talent Acquisition Coordinator (Contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Contract Document Specialist II will provide critical support for managing Stability documents in Veeva electronic Document Management System (EDMS), ensuring timely processing of documents while adhering to internal procedures and requirements in a GXP compliant environment. The position requires strong attention to detail, organizational skills, and the ability to collaborate effectively with cross-functional teams. Essential Functions: Perform document specialist functions in Quality Assurance, including managing the lifecycle of Stability documents in Veeva and other electronic systems where required, including creation, revision, approval, distribution and archival, ensuring compliance with internal procedures and regulatory standards. Work closely with Project Management, Stability, Quality Assurance and other functional areas as well as external vendors for daily management of routing, revisions, approval, and filing of documents within defined timelines. Organize and ensure accurate and reliable filing systems for all GMP documents. Requirements:&nbsp; Bachelor’s BA/BS degree or equivalent experience and minimum of 2 years of biopharmaceutical industry experience. Other combinations of education and/or experience may be considered. Experience with managing key Quality Management System processes (e.g., Document Control, Change Management). 2+ years of experience with document management utilizing EDMS systems. Experience with Veeva QualityDocs strongly preferred. Familiarity with documents and records associated with GxP testing activities. Understanding of current regulatory expectations including 21CFR Part 11 requirements. Demonstrated ability to collaborate cross functionally. Strong professional interpersonal and communications skills, both verbal and written, to provide clear direction for the business, vendors, and internal stakeholders. Strong attention to detail, organizational skills, ability to work in a faced paced environment. Ability to meet deadlines and multi-task efficiently. Working knowledge with Microsoft Word, Excel, Adobe and PowerPoint. Reports to: Senior Manager, Quality Assurance &nbsp; Location: San Carlos, CA; Open to Remote &nbsp; Expected Contract Length:&nbsp;6-7 months &nbsp; Hourly Range:&nbsp;$43.00 - $47.00 (SF Bay Area) &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

QA Document Specialist II (contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join Vaxcyte’s Facilities organization. The primary function of this Director-level position is to lead Facilities operations and site services for Vaxcyte’s Headquarters and to develop and maintain global security programs and policies. This position will manage and grow a high-performing and service-centric team comprised of full-time employees, contingent workers and 3rd party partners. Beyond functional and technical experience, the primary keys to success for this role focuses on relationships, culture, trust, forward thought, and operational excellence. This position reports to the Senior Director Facilities and will work out of Vaxcyte’s San Carlos office. &nbsp; Note: rotational, shared 24x7 on-call support is required of this role. Essential Functions: Partner closely with the Director of Lab Operations to establish, monitor and maintain the labs and all lab equipment. Support planning oversight for the installation of lab equipment. Help cultivate a culture of compliance with job-appropriate policies, procedures and training. Collaborate, develop and evolve a rolling 3-5 year strategic Facilities roadmap for Vaxcyte’s HQ and associated spaces. Develop and maintain oversight of Vaxcyte’s global security program.&nbsp; This will include the development of access controls, oversight of Security for Vaxcyte’s HQ in San Carlos, develop visitor/vendor management protocols and practices and any governance documents/polices required under a global security envelop. Plan and co-lead relocations, expansions and redesign initiatives. Oversee ongoing space planning and assignment move/add/change efforts. Manage site functions as assigned. Establish and maintain 24x7 on-call schedule, site lead roster and emergency call tree for Facilities team. Help drive key processes and systems related to Facility operations to ensure they are integrated and monitored. Develop building and equipment standards, including Basis of Design for labs and office spaces to support future growth and development Implement and maintain an Integrated Workplace Management System (IWMS). Maintain master calendar for required inspections, preventative maintenance, submissions, renewals, and (re)certifications via Facilities Computerized Maintenance Management System (CMMS).&nbsp; CMMS will be the master database for the general facilities including the Labs and lab equipment. Establish and operationalize strategic relationships with key external partners. Lead, coach and manage a high-performing Facilities team with a focus on career growth. Help nurture and grow workplace engagement through creative Facilities solutions. Liaise regularly with property managers, external agencies and key 3rd party partners. Engage regularly with employees and business partners to forge relationships and build trust. Operationalize and/or automate Facilities functions for improved consistency and efficiency. Support the development of procedures that comply with appropriate cGxP and other statutory requirements. Manage Vaxcyte HQ Facilities projects and serve as SME for cross-functional and enterprise initiatives. Establish functional KPI’s and report regularly on performance against metric/measure targets. Create a customer-centric Facilities support capability built upon solid process and technology. Work with IT and business partners to identify, implement and evolve Facilities systems. Partner closely with Finance to establish, monitor and maintain Facilities budgets. Plan, oversee and track Facilities-related procurement; help optimize procurement process. Serve as Facilities SME and point of contact during audits. Assist with Vaxcyte’s emergency and continuity planning with ongoing table-top exercises. Support troubleshooting and perform minor repairs in office and laboratory settings. Member of Emergency Response Team. Requirements:&nbsp; BS in Engineering or similar technical-related degree, with 12 years Facilities experience in the life sciences industry, biotech preferred. 5+ years’ people-management experience required. Other combinations of education and/or experience may be considered. Project management experience with office and lab builds; manufacturing a plus. Expert-level proficiency with facilities and lab systems such as BMS, CMMS, ELN/LIMS. Proficient, hands-on experience with biotech facility and laboratory instruments and equipment. Relentless focus and passion around process improvements (efficiency and automation). Fluent in Facilities-related statutory/regulatory requirements for a public life sciences company. Proficiency developing and managing corporate EH&amp;S programs. Compete training and maintain training qualifications for ERT Practical experience with system/equipment qualification plans and protocols. Ability to thrive in a highly dynamic and fluid environment where priorities may quickly change. Excellent communication, customer service and relationship skills are an absolute must. Reports to: Senior Director, Facilities &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $197,000 - $230,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Facilities

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The primary function of this position is to manage material inventory, storage and shipments through Vaxcyte’s service provider and partner ecosystem (i.e., CDMOs, CROs, Suppliers, Shippers, and Authorities). Materials can include chemicals, consumables, critical raw materials, intermediates, drug substances and drug products. This position will provide a crucial role in timely, accurate and compliant material movement across, and within, Vaxcyte’s supply chain. It is necessary to possess working knowledge of GxP (GMP, GLP, GCP) regulations as they pertain to the shipment, receipt, and storage of regulated materials. Solid expertise with global shipping is essential in this role, as is customer service excellence. Essential Functions: Serve as the single-point-of-intake for shipping requests, subsequent processing, tracking and record maintenance. Prepare all required shipping documentation. Ensure all required licenses, permits, and insurance are in place prior to shipment. Coordinate with logistics partners to ensure smooth delivery to customers. Monitors service and delivery issues and takes corrective actions as needed. Coordinate investigation and resolution of temperature excursions. Interpret shipping provisions in contracts and apply them during shipment planning and execution. Assist in developing shipping procedures and general shipment guidelines. Establish strong relationships with specialty shipping service providers, freight forwarders, and 3PLs. Maintain an internal database of shipments and inventory. Capture and enter requisite shipping and inventory data in information systems or other tools. Assist with preparing inventory and shipping reports, dashboards, and KPIs for Vaxcyte stakeholders. Partner with departments across the company to ensure internal customers are satisfied. Assist in overseeing material inventory internally and across service providers. Requirements:&nbsp; Commercial education (e.g Federal Diploma), or Bachelor’s degree, in a relevant filed. 5+ years’ logistics experience in Life Sciences or other regulated industry. Other combinations of education and/or experience may be considered. Excellent understanding of cGMP materials management and global shipping. Fluent with global shipping-related statutory and regulatory requirements. Knowledge of Incoterms. Knowledge of legal export/import requirements and shipping document preparation. Understanding of requirements, technologies, and processes of cold-chain supply management. Experience with arranging international and domestic transportation. Understand licensing, insurance, and importer of record requirements. Experience authoring and using GxP documents such as SOP’s and work instructions. Understanding of customs, tariffs, VAT etc. in Europe, North America and Asia. Relentless focus and passion around process improvements (efficiency and automation). Excellent communication, customer service and relationship skills. Excellent analytical skills. Knowledge of ERP, MS Office and other relevant applications. Fluent in English. Fluency in German highly preferred; Italian and other European languages an advantage. Reports to: Director, Supply Chain Europe &nbsp; Location: Zug, Switzerland or Visp, Switzerland &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Specialist, Logistics

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Engineer for Drug Substance (DS) Commercialization has the accountability for launch readiness and commercial supply of of critical raw materials for production of eCRM and associated components for glycoconjugate vaccines.&nbsp; This role focuses on technical planning and execution by bringing best-practices and developing and executing technical deliverables in support of regulatory filings, facility readiness, and launch supplies. This position will be reporting into the Senior Director for Global DS Commercialization, Protein. The Sr. Engineer will collaborate on overall program strategy, with primary responsibility and accountability for the scale down model strategy execution, gap closure and robustness studies, person-in-plant SME support for manufacturing campaigns, and robustness study design and execution for protein and associated critical raw materials. Global Manufacturing Science and Technology (GMSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. As part of the Technical Operations organization, GMSAT will lead the technical and process support for end-to-end commercial manufacturing, including Polysaccharides, Carrier Proteins, Conjugation across all Drug Substances (DS). The range of activities will include DS technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, and investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle etc.&nbsp; Essential Functions: DS Commercialization – Provide engineering leadership for eCRM and associated raw materials with internal and external stakeholders and ensure successful execution of technical deliverables in support of launch plans and post-launch commercial activities. Process robustness – Continuously improve process understanding and process robustness by identifying and closing technical gaps in place to monitor, trend, and optimize operations. Interface - Collaboration with cross-functional teams across the network, including Regulatory, Process Development, Quality, Supply Chain, Procurement, and DS Operations, to drive the successful development and commercial launch of carrier proteins for pipeline products. Provides technical representation into initial technology transfer, product launch, product lifecycle, to the end of life/product retirement and for defining/developing the next generation of production technologies. Tech-transfer new technologies - Ensure robust processes exist to support technical transfers and integration of new technologies, including person in plant support as required. Support technical services - Support of our internal and external manufacturing network, including materials management and data analytics. Process validation and comparability - Provide support for the execution of process validation and process comparability activities. Regulatory - Engage In technical reviewing and authoring of regulatory filings and responding to questions received from health authorities. Communicate - Effectively and efficiently communicate process performance to key stakeholders (internal-facing and external-facing). Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Executing for Results - Set clear and challenging goals and take accountability for driving results. Comfortable with ambiguity and uncertainty; the ability to adapt nimbly and lead others through complex situations. Leadership - Contribute as member of the DS Commercial MSAT team, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Travel - 10-30% travel required. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 5+ years of relevant experience for Ph.D., 10+ years for M.S./M.A., or 13+ years for B.S./B.A. Broad experience in protein processes, including bacterial fermentation, recovery, and purification across multiple operational scales. Experience with cell free protein synthesis and associated critical raw materials desired. Able to leverage deep technical knowledge in a collaborative manner to achieve collective goals. Excellent organization, problem solving and strategic planning skills. Highly skilled in both verbal and written communication with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges, and independently identifies and implements effective steps and solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Senior Director, Global DS Commercialization Lead, Protein &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Engineer, Global Drug Substance Commercialization, Protein

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: Vaxcyte is looking for an energetic and talented individual to join our Drug Product Development team. The candidate must have knowledge of and practical experience in analyzing and characterizing biomolecules (proteins, polysaccharide conjugates, vaccines) using a variety of methods, including immunoassays, chromatography, spectrophotometric techniques, light scattering, and particle sizing. Experience in analyzing vaccine and adjuvant-containing formulations is a plus. In addition, Vaxcyte is looking for an experienced and flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a lab-based scientific role and requires excellent scientific judgement, independence, rigor, and thorough record-keeping. Essential Functions: Routine and non-routine analysis of internal release, development, and stability samples and reporting of data using multiple analytical techniques across the Drug Product working groups. Executing non-GxP stability study analysis for thermal, freeze/thaw, and agitation as well as container closure system evaluation for both Drug Substance and adjuvanted vaccine Drug Product materials. Support the Vaxcyte PCV and VAXA1 products, external analytical, and manufacturing CMOs to enable tech transfer and implementation of processes and analytical methods. Vaxcyte is looking for a flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a scientific role, which is predominantly lab-based, requiring excellent scientific judgement, independence, rigor, and thorough record-keeping. Requirements:&nbsp; MSc with 1 year of experience, or a BSc with a minimum of 2 years of experience the in pharmaceutics and or biotechnology industries. Chemistry, Biophysics or Biochemistry preferred. The candidate will preferably have established practical experience in the analytical characterization of large biomolecular Drug Products in pre-filled syringes and vials. Experience executing bioanalytical components of product release testing and long-term stability studies, including biochemical, biophysical, and compendial methods. Experience in plate-based assays, multiplexed immunoassay (MSD), chromatography methods (UV and fluorescence detection), compendial methods (osmolality, pH, etc), and spectrometric methodologies. Experience in authoring analytical technical documents, including method protocols, SOPs, and reports, as well as experience recording and templating electronic laboratory notebooks (eLN). The candidate should have high degrees of both flexibility and organizational skills as well as an eagerness and ability to learn, to effectively navigate Vaxcyte’s multiple projects and timelines. Strong interpersonal skills; ability to communicate effectively both verbally and in written formats are necessary to collaborate effectively with the rest of the Formulation and Drug Product Development team, as well as train other analysts and team members. Detail-oriented, rigorous, and excellent skills in record keeping. Reports to: Scientist II, Drug Product Analytics &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $100,000 – $118,000 &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Drug Product Analytics

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking an experienced Sr. Manager, Clinical Programmer, to lead and deliver high-quality programming solutions for clinical trials and regulatory submissions. This role requires strong technical expertise, leadership skills, and the ability to collaborate across multiple functions to ensure timely and compliant deliverables. Essential Functions: You will play a critical role in clinical data programming and submission activities. Responsibilities include, but are not limited to: Statistical Analysis Execution: Independently develop, validate, and maintain complex programs and utilities to generate tables, listings, and figures (TLFs) for clinical study reports in accordance with the Statistical Analysis Plan. Regulatory Submission Deliverables: Develop, review, and validate CDISC-compliant e-submission components, including: Annotated CRF (acrf.pdf) SDTM specifications and datasets ADaM specifications and datasets xml or define.pdf Study Data Reviewer’s Guide (cSDRG.pdf) Analysis Data Reviewer’s Guide (ADRG.pdf) Collaboration: Partner with statisticians to finalize mock tables and ensure alignment with analysis requirements. Vendor Management: Oversee programming vendors to ensure quality deliverables, adherence to timelines, and complete project documentation. Cross-Functional Support: Work with Data Management to resolve data issues. Collaborate with Clinical Operations to integrate data from multiple sources. Coordinate with Clinical/Regulatory Writing to standardize output and processes for various submissions. Ad Hoc Analysis: Perform analyses for internal or regulatory requests under statistical guidance. Integrated Submissions: Compile data across studies for ISS/ISE and related electronic submission deliverables. Process Improvement: Drive standardization of programming rules and support visualization capabilities for enhanced reporting. Requirements:&nbsp; Bachelor’s degree in Computer Science, Statistics, or related discipline with minimum 8 years experience in clinical programming and minimum 3 years in vaccine clinical studies with BLA e-submission experience. Other combinations of education and/or experience may be considered. Proficient in SAS; experience with R or Python is a plus Strong knowledge of CDISC standards (SDTM, ADaM) and FDA OVRR guidance Familiarity with ICH, GCP, clinical research processes, and regulatory requirements Detail-oriented with excellent problem-solving abilities; strong communication and coordination skills; ability to manage multiple priorities and vendors effectively Reports to: Executive Director, Clinical Biostatistics &nbsp; Location: US - Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $161,000 – $188,000&nbsp;(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Clinical Programmer

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is undergoing a major ERP transformation, moving from NetSuite to SAP S/4HANA to support its rapid growth&nbsp;and upcoming transition to commercial operations.&nbsp;The&nbsp;Senior&nbsp;IT&nbsp;Business&nbsp;Systems&nbsp;Analyst (BSA),&nbsp;SAP&nbsp;Finance&nbsp;will play a critical role in bridging Finance and IT, ensuring a smooth transition and successful implementation of SAP S/4HANA Finance modules. This position requires strong functional&nbsp;expertise&nbsp;in SAP Finance, deep understanding of accounting processes, and experience in ERP migration projects.&nbsp; Essential Functions: Support the migration from&nbsp;NetSuite to SAP S/4HANA, ensuring data integrity and process continuity.&nbsp; Collaborate with Finance and IT teams to design future-state processes aligned with&nbsp;Vaxcyte’s&nbsp;business needs.&nbsp;&nbsp; Assist&nbsp;in data mapping, cleansing, and validation during migration.&nbsp; In-depth knowledge of SAP systems, including SAP S/4HANA and integration techniques.&nbsp; Configure and&nbsp;maintain&nbsp;SAP Finance modules&nbsp;including Financial Accounting (FI), Controlling (CO), Treasury &amp; Cash Management, Financial Close &amp; Reporting, and Procurement.&nbsp;&nbsp; Work closely with Finance stakeholders (Accounting, FP&amp;A,&nbsp;Procurement) to capture requirements.&nbsp; Translate business needs into functional specifications for SAP configuration.&nbsp; Help develop and document business process flows.&nbsp; Develop and execute test plans for SAP Finance processes.&nbsp; Support&nbsp;User Acceptance Testing (UAT)&nbsp;and resolve issues promptly.&nbsp; Create training materials and deliver sessions for Finance users transitioning from NetSuite.&nbsp; Provide ongoing support&nbsp;post go-live.&nbsp; Ensure compliance with GAAP and biotech industry standards.&nbsp; Requirements:&nbsp; Minimum 7&nbsp;years of experience&nbsp;as a BSA with SAP Finance modules.&nbsp;Other combinations of education and/or experience may be considered.&nbsp; Bachelor’s degree in&nbsp;Finance, Accounting, Information Systems, or related field.&nbsp; Strong analytical and problem-solving skills, with the ability to&nbsp;identify&nbsp;issues and implement effective solutions.&nbsp; Experience in&nbsp;identifying&nbsp;and managing project risks, with a proactive approach to mitigation.&nbsp; &nbsp;Familiarity with&nbsp;change management principles and techniques to&nbsp;facilitate&nbsp;smooth transitions and adoption of new systems.&nbsp; Hands-on experience with&nbsp;SAP S/4HANA Finance&nbsp;(implementation or migration projects preferred)&nbsp;and Fiori applications.&nbsp;&nbsp; Experience with&nbsp;Netsuite&nbsp;preferred.&nbsp; Experience developing and mapping business process flows using Visio or similar tool&nbsp; Strong understanding of&nbsp;financial processes&nbsp;and ERP migration best practices.&nbsp; Excellent communication and stakeholder management skills.&nbsp; SAP certification in FI/CO&nbsp; Expertise&nbsp;with agile&nbsp;methodology, global deployments, and data migration planning.&nbsp; Experience working in&nbsp;GxP&nbsp;validated and SOX regulated systems&nbsp; Knowledge of&nbsp;integrated tools&nbsp;(e.g.,&nbsp;BlackLine, Concur, Ariba) and reporting solutions.&nbsp; Other combinations of education and/or experience may be considered.&nbsp; Reports to:&nbsp;Director, IT Finance Systems &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior IT Business Systems Analyst, SAP Finance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for a talented Document Control Specialist, who will be responsible for the processing of GxP documentation as part of the Quality Management System. This includes, but is not limited to, Standard Operating Procedures, Work Instructions, Forms, and Templates. Essential Functions: Maintain Quality System documentation in Veeva (electronic document control system) and other electronic systems where required. Format documents to comply with Vaxcyte templates. Independently perform the QA document control function, managing document workflows in Veeva, tracking, processing, routing, distributing, and archiving documents/records with overall responsibility for document control Engage key clients to understand expectations and problem areas and has the ability to address and resolve conflicts. Participate in developing and editing of new SOPs and work instructions. Ability to identify risks to program/process and propose solutions. Work closely with functional areas for daily management of routing, revisions, approval, and filing of documents within defined timelines. Organize and ensure accurate and reliable filing systems for all electronic Requirements:&nbsp; Bachelor’s BA/BS degree or equivalent experience and minimum of 5 years of biopharmaceutical industry experience. Other combinations of education and/or experience may be considered. Experience working with documents and records in a GxP environment relating to manufacturing and testing activities. Familiar with Veeva Vault in a Document Control capacity. Understanding of current regulatory expectations including 21CFR Part 11 requirements. Strong professional interpersonal and communications skills, both verbal and written, to provide clear direction for the business, vendors, and internal stakeholders. Strong attention to detail, organizational skills, ability to work in a faced paced environment. Ability to meet deadlines and multi-task efficiently. Proficient with Microsoft Office Suite, Word, Excel, PowerPoint. Reports to: Director, Document Control &nbsp; Location: San Carlos, CA; Hybrid &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $115,000 – $134,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Document Control Specialist III

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Director, Medical Affairs is a senior leadership role responsible for shaping and executing the medical strategy for the company’s vaccine portfolio. This position combines traditional headquarters medical affairs responsibilities with direct oversight of a Medical Science Liaison (MSL) team and engagement with national vaccine recommending bodies and professional organizations. The role ensures scientific excellence, compliance, and alignment with Vaxcyte and public health priorities. Essential Functions: Contribution to development and implementation of medical affairs strategy for vaccines across the product lifecycle. Provide scientific and clinical expertise to support regulatory submissions, labeling, and safety monitoring. Collaborate with clinical development, regulatory, and commercial teams to ensure consistent scientific messaging. Offer strategic input and thought leadership in publication planning, medical education, and evidence generation initiatives. Monitor emerging data, guidelines, and competitive intelligence to inform strategy. Manage and mentor a team of MSLs, ensuring effective scientific exchange and stakeholder engagement. Align field insights with HQ strategy to drive evidence-based decision-making. Establish performance metrics and professional development pathways for MSLs. Foster collaboration between HQ and field medical teams to ensure seamless execution. Build and maintain relationships with key organizations making vaccine recommendations Represent the company in scientific and policy discussions related to immunization guidelines and vaccine adoption. Provide medical leadership at advisory boards, scientific congresses, and public health forums. Influence vaccine policy and recommendations through evidence-based advocacy. Requirements:&nbsp; Advanced degree (PharmD, PhD, MD, or equivalent) in life sciences, immunology, infectious diseases, or public health. A minimum of 12 years progressive experience in medical affairs, including leadership roles. Proven track record in vaccines or infectious disease therapeutic areas. Experience managing MSL teams and integrating field insights into HQ strategy. Strong understanding of immunization policy, public health systems, and regulatory frameworks. Exceptional communication, presentation, and interpersonal skills. Ability to travel up to 70% of the time. Other combinations of education and/or experience may be considered. Reports to:&nbsp;Vice President, Medical Affairs &nbsp; Location:&nbsp;Remote - US &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $266,000 - $310,000&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Medical Affairs

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Director, Medical Operations is a senior leadership role responsible for overseeing medical communications, medical information, and operations for the organization. This position ensures scientific accuracy, compliance, and operational excellence across all medical affairs activities, while supporting the company’s mission to advance immunization and public health. Essential Functions: Lead development of scientific communication strategies, including publications, congress presentations, and internal training materials. Oversee creation of scientific and medical content for advisory boards, symposia, and scientific meetings. Support consistent and accurate messaging across medical affairs and commercial teams. Drive publication planning and execution in collaboration with partners, including clinical development and external experts. Design and implement a transparent, compliant medical education grant process. Establish and lead the medical information function for vaccines, including processes, systems, and staffing. Oversee medical affairs operations, including budget management, compliance, and process optimization. Provide leadership in governance processes, ensuring adherence to regulatory and ethical standards. Requirements:&nbsp; Advanced degree (PharmD, PhD, MD, or equivalent) in life sciences, immunology, infectious diseases, or public health. A minimum of 12 years of progressive experience in medical affairs, medical communications, or medical information, with leadership responsibilities. Proven expertise in vaccines or infectious disease therapeutic areas. Experience building medical information functions and developing medical education grant processes. Strong knowledge of compliance frameworks, regulatory requirements, and industry standards. Exceptional leadership, communication, and strategic thinking skills. Ability to travel up to 25% of the time. Other combinations of education and/or experience may be considered. Reports to:&nbsp;Vice President, Medical Affairs &nbsp; Location:&nbsp;Remote - US &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $258,000 - $301,000We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Medical Affairs Operations

Senior Director, Medical Affairs (West)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Sr. Manager, Quality Assurance, External Manufacturing will play a critical role in ensuring the highest standards of product quality and compliance across contract manufacturing operations. This position provides QA oversight of Contract Manufacturing Organizations (CMOs), leads batch disposition and documentation review, and represents QA on cross-functional and joint project teams. The ideal candidate is an experienced quality professional with a strong understanding of cGMP and global regulatory standards, capable of driving continuous improvement and fostering a culture of quality excellence across all manufacturing activities. Essential Functions: Provide Quality Assurance oversight of Contract Manufacturing Organizations. Represent QA at internal cross functional team meetings and at Joint Project Team meetings. Lead batch disposition activities such as review of executed batch records, environmental monitoring and quality control data. Review and approve documentation such as master batch records, deviations, risk assessments, change controls, and CAPAs. Drive resolution of quality performance issues with the contract manufacturer. Support validation activities. Develop, implement and maintain procedures and policies. Interact with key stakeholder to develop solutions to complex issues. May participate in compliance audits as required. Promote a quality mindset and quality excellence approach to all activities. Requirements:&nbsp; Bachelor’s degree in Chemistry, Biology, Pharmacy, Engineering, or a related field. Minimum of 8 years of experience in quality assurance, batch record review, manufacture, or quality systems management within the pharmaceutical, biotechnology, or life sciences industry. Other combinations of education and/or experience may be considered. Strong knowledge of cGMP, ICH guidelines, FDA/EMA regulations, and other international pharmaceutical quality standards. Knowledge and experience in Risk Management principles. Knowledge in both clinical and commercial product desired. Strong Management and process improvement skills. Demonstrated experience managing batch record review and deviations. Great organization skills and have an attention to details. In-depth understanding of biologics manufacturing operations. Good ability to prioritize multiple assignments and changing priorities. Excellent problem-solving skills and the ability to manage complex investigations and root cause analyses. Strong written and verbal communication skills, with the ability to clearly present quality issues to cross-functional teams. Reports to: Director, Quality Assurance, External Manufacturing &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $158,000 – $184,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Assurance, External Manufacturing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.&nbsp; Summary: The Sr. Manager, QA, Raw Materials ensures quality oversight and compliance across manufacturing activities. This role serves as the QA liaison for internal teams and external partners, reviewing and approving key documentation and materials, driving resolution of quality issues, and ensuring adherence to regulatory standards. The position also supports process improvements, policy development, and effective collaboration to uphold Vaxcyte’s commitment to quality excellence. Essential Functions: Serve as QA Manufacturing representative for Critical Raw Materials. Represent Quality Assurance at internal and external cross functional team meetings, providing quality input and oversight. Review and approve internal and external documentation for compliance including Master Batch Records, deviations, risk assessments, change controls, and CAPAs. Perform QA review of CMO executed batch records in compliance with current regulatory guidance and industry practices and follow up on CMO responses as needed. Prepare disposition package of Critical Raw Materials to enable timely release. Review and approve Raw Materials shipment authorization forms in accordance with established procedures. Develop, implement, and maintain procedures and policies related to critical Raw Materials and the Vaxcyte quality organization, ensuring alignment with quality and regulatory standards. Identify compliance gaps and drive resolution of quality and performance issues with contract manufacturers and proactively escalate issues to management, when appropriate. Provide guidance on Manufacturing investigations and ensure implementation of effective Corrective and Preventative Actions. Exercise sound judgement and decision-making. Facilitate process improvement projects to enhance efficiency, compliance, and quality performance. Collaborate with key stakeholders to develop solutions to complex issues while promoting quality standards of excellence. Requirements:&nbsp; BS or BA with a minimum 8 years of experience. Other combinations of education and/or experience may be considered. In-depth knowledge of GMPs, FDA regulations and ICH guidelines. Strong attention to detail. Knowledge in both clinical and commercial product. Excellent verbal, written, and interpersonal communication skills. Experience leading and contributing through influence and working in cross functional teams. Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Strong overall knowledge of manufacturing processes and Quality Systems. Reports to: Director, Quality Assurance Raw Materials &nbsp; Location: San Carlos, CA; Open to remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $164,000 - $191,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Assurance, Raw Materials

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Scientist I to manufacture and test all reagents required for immunoassay detection of multi-valent vaccines. In particular, the reagents we are using need to be conjugated to different entities and then characterized and catalogued for our multiplexed assays. Extreme control of this assay is required to maintain DS shelf life and more importantly, ensuring DP compounding is successful in relation to the final dose of each DS in the clinic. We require an Associate Scientist I who will continue the development and optimization of assay suites for our current 3 programs, and for upcoming research projects. This person will be part of a larger team that will continue this development.&nbsp; The role requires an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities. In addition, the successful candidate will require significant experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen. Essential Functions: Help continue the development and optimization of assay suites for our current 3 programs, and for the following research projects. Have an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities. Demonstrate experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen. Requirements:&nbsp; BSc 0-2 years in Molecular Biology, Chemistry, Analytical Chemistry, Organic Biochemistry considered. Ideal candidate will have a significant background in plate-based assay development and antibody characterization including HPLC and Octet. Experience in protein analysis such as SEC, HPLC, SDS-page, CE-SDS, and cIEF and binding kinetics is a plus. Having a high degree of organizational capabilities for both reagents and experimental scheduling a must. Prior experience of transferring methods to external partners for validation and GMP activities will be of a significant benefit, and first-hand experience of a QC environment would also be advantageous. Experience in immunoassay development, qualification, validation, trouble shooting and aiding in OOS investigations is highly desired. The ability to present complex data sets and independently propose and design follow-up experiments are also required. Maintaining good laboratory practices, safety and record keeping for them-selves and their team is required. Reports to: Senior Manager, Nonclinical and Immunoassay &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $81,000 – $94,000 &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist I, Clinical Serology, Nonclinical & Immunoassay

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: This leadership role is responsible for developing and implementing global regulatory strategies in collaboration with Product Development and Material Science and Technology functions to enable and facilitate the development, commercialization, regulatory approval and lifecycle management of novel vaccine products. Essential Functions: Experience developing and implementing regulatory strategies for vaccines and preparing investigational and commercial regulatory applications, i.e., IND/IMPD, BLA/MAA, post-approval changes and global regulatory approvals. Strong communication skills, in particular, the ability to distill complicated issues and regulatory risks and effectively articulate options and opportunities for reconciliation, are essential. Must be comfortable with interfaces at all levels of the organization, including senior leadership, Level 1 – 4 multi-disciplinary teams, and with external partners, CDMOs/CROs and regulatory authorities. Strong technical background in vaccine development and manufacture for commercialization. Regulatory experience including a thorough understanding of global regulatory requirements and expectations, and the ability to influence and shape regulatory strategies in a dynamic environment is imperative. Strategic vision, attention to detail, and a passion for regulatory excellence are key attributes for success in this position. Develop and execute globally viable regulatory strategies. Develop, author and review regulatory CMC documentation for submission including application documents, correspondence and responses to queries. Provide regulatory guidance for L2, L3 and L4 cross functional development teams. Ensure adherence to current regulatory requirements and alignment with appropriate regulatory guidance (including ICH) and industry best practices. Serve as a primary point of contact with regulatory authorities, i.e., FDA, EMA, MHRA, PMDA, Health Canada, etc., as appropriate. Lead interactions and negotiations w/global regulatory authorities for reconciliation of specific technical issues to expedite regulatory application submissions and approvals. Provide guidance on contemporary regulatory intelligence, statutory legislation and changes in regulatory authority requirements and expectations. Manage cross-functional teams to demonstrate and ensure regulatory compliance. Optionally, people development and management may be expected. Requirements:&nbsp; Education: At a minimum, a BA or BS in a relevant scientific or technical discipline, i.e., chemistry, biochemistry, pharmaceutical sciences, or related life sciences, is required with 15+ years industry experience that demonstrates technical and regulatory expertise and competence.&nbsp; Graduate education and/or professional certifications or training in regulatory and/or quality are a bonus. Other combinations of education and/or experience may be considered Regulatory Experience: 10+ years of extensive and relevant regulatory experience with a proven record of achievement in developing and prosecuting regulatory submissions and application approvals within the pharmaceutical or biotechnology industry with a particular emphasis on vaccines and CMC content. Technical Expertise: A thorough understanding of technical, operations, manufacturing and controls of pharmaceutical products and particular experience with vaccine development and commercialization. Global Regulatory Expertise: Direct experience engaging multiple health authorities, i.e., FDA, EMA, MHRA, Health Canada, etc., and preparation of regulatory applications for global health authorities.&nbsp; Leadership: Demonstrated ability to lead and manage cross-functional teams, developing and establishing regulatory strategies and preparing regulatory applications including review and submission of CMC documentation to regulatory authorities. Lifecycle Management: Direct experience developing regulatory CMC strategies and submissions to effectively deliver post-approval changes and optimizations for commercial vaccines. Strategic Regulatory Expertise: Demonstrated record identifying technical and regulatory risks and developing strategies and/or contingencies for mitigation and transparent commitment to quality. Business Acumen: Experience translating and integrating contemporary regulatory intelligence into appropriate internal policies and practice. Competencies and Skills: Articulate oral and written communication skills Active listening Strategic and tactical critical thinking Constructive operational productivity Adaptability Flexible and optimistic demeanor Reports to: SVP &amp; Head of Regulatory Affairs &amp; Quality Assurance &nbsp; Location: Remote, USA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $300,000 - $350,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Executive Director, CMC Regulatory

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Scientist II to manufacture and test all reagents required for&nbsp;immunoassay detection of multi-valent vaccines. In particular, the reagents we are using need to be conjugated to&nbsp;different entities and then characterized and catalogued for our multiplexed assays. Extreme control of this assay is&nbsp;required to maintain DS shelf life and more importantly, ensuring DP compounding is successful in relation to the final&nbsp;dose of each DS in the clinic. We require an Associate Scientist II who will continue the development and optimization of assay suites for our current&nbsp;3 programs, and for upcoming research projects. This person will be part of a larger team that will continue this&nbsp;development. The role requires an extremely high level of organization, and the ability to maintain large volumes of&nbsp;data for the various DS and DP entities. In addition, the successful candidate will require significant experience in&nbsp;developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes&nbsp;generating high-affinity antibodies specific to the antigen. Essential Functions: Help continue the development and optimization of assay suites for our current programs, and for the&nbsp;following research projects. Have an extremely high level of organization, and the ability to maintain large volumes of data for the various DS and DP entities. Demonstrate experience in developing, trouble shooting and running ELISA-type assays, including generation of the critical reagents, which includes generating high-affinity antibodies specific to the antigen and reviewing production protocols, requesting quotes, interacting with vendors, collecting and providing updates on production timelines. Collaborate closely with external Vaxcyte Team members and to ensure supply/demand, DS and DP methods, CMO status and timelines are all in sync with assay development activities to hit milestones as needed. Requirements:&nbsp; Bachelor’s degree (BSc) in Molecular Biology, Chemistry, Analytical Chemistry, or Organic Biochemistry with a minimum 2 years of relevant experience, or Master’s degree (MSc) in the same fields with minimum 1 year of relevant experience or an equivalent combination of education and experience. Ideal candidate will have a significant background in plate-based assay development and antibody characterization including Akta, HPLC and BLI. Experience in protein analysis such as SEC, HPLC, SDS-page, CE-SDS, and cIEF and binding kinetics is a plus. Having a high degree of organizational capabilities for both reagents and experimental scheduling a must. Prior experience of transferring methods to external partners for validation and GMP will be of a significant benefit, and first-hand experience of a QC environment would also be advantageous. Experience in immunoassay development, qualification, validation, trouble shooting and aiding in OOS investigations is highly desired. The ability to present complex data sets and independently propose and design follow-up experiments are also required. Maintaining good laboratory practices, safety and record keeping for them-selves and their team is required. Reports to: Senior Manager, Clinical Serology, Nonclinical &amp; Immunoassay Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $105,000 – $122,000 *(SF Bay Area).&nbsp; &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Nonclinical & Immunoassay

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: This leadership role is responsible for developing and implementing global regulatory strategies for clinical investigational studies and commercialization of vaccines for both adult and pediatric populations.&nbsp; In collaboration with Clinical Development and Safety this role is responsible for regulatory guidance that enables and facilitates the preparation of clinical development protocols, interpretation and summary of clinical results, initiation, development and preparation of clinical and pre-clinical regulatory documents, correspondence and responses to regulatory authorities toward commercial regulatory approval of novel vaccine products.&nbsp; The role requires experience developing and implementing regulatory strategies for vaccines and preparing investigational and commercial regulatory applications, i.e., IND/IMPD, BLA/MAA, post-approval clinical and safety notifications and global regulatory approvals.&nbsp;&nbsp; Strong communication skills, in particular, the ability to distill complicated issues and regulatory risks and effectively articulate options and opportunities for reconciliation, are essential.&nbsp; The Executive Director must be comfortable with interfaces at all levels of the organization, including senior leadership, Level 1 – 4 multi-disciplinary teams, and with external partners, CDMOs/CROs and regulatory authorities.&nbsp;&nbsp; The ideal candidate possesses a clinical background in vaccine development and relevant experience in development and execution of clinical protocols.&nbsp; Regulatory experience including a thorough understanding of global regulatory requirements and expectations, and the ability to influence and shape regulatory strategies in a dynamic environment is imperative.&nbsp; Strategic vision, attention to detail, and a passion for regulatory excellence are key attributes for success in this position. Essential Functions: Develop and execute globally viable clinical regulatory strategies. Develop, author and review regulatory CMC documentation for submission including application documents, correspondence and responses to queries. This includes requests for scientific advice in EU, Switzerland, UK and Canada, etc.&nbsp; Provide regulatory guidance for L2, L3 and L4 cross functional development teams. Ensure adherence to current regulatory requirements and alignment with appropriate regulatory guidance (including ICH) and industry best practices. Serve as a primary point of contact with regulatory authorities, i.e., FDA, EMA, MHRA, PMDA, Health Canada, etc., as appropriate. Contribute to the development of product label claims and justifications for clinical outcomes. Lead interactions and negotiations w/global regulatory authorities for reconciliation of specific clinical and pre-clinical issues to expedite regulatory application submissions and approvals. Support regulatory requirements for safety/pharmacovigilance notifications to regulatory authorities. Provide guidance on contemporary regulatory intelligence, statutory legislation and changes in regulatory authority requirements and expectations. Manage cross-functional teams to demonstrate and ensure regulatory compliance. Optionally, people development and management may be expected. Requirements:&nbsp; BA or BS in a relevant scientific or technical discipline, i.e., clinical pharmacology, immunology, biology, medicine, bioanalytics or related life sciences, is required with 15+ years industry experience that demonstrates technical and regulatory expertise and competence.&nbsp; Graduate education and/or professional certifications or training in regulatory and/or quality are a bonus. Other combinations of education and/or experience may be considered 10+ years of extensive and relevant regulatory experience with a proven record of achievement in developing and prosecuting regulatory submissions and application approvals within the pharmaceutical or biotechnology industry with a particular emphasis on vaccines and clinical content. A thorough understanding of clinical development, statistics with particular experience with vaccine development and commercialization. Direct experience engaging multiple health authorities, i.e., FDA, EMA, MHRA, Health Canada, etc., and preparation of regulatory applications for global health authorities.&nbsp; Demonstrated ability to lead and manage cross-functional teams, developing and establishing regulatory strategies and preparing regulatory applications including review and submission of clinical and pre-clinical documentation to regulatory authorities. Direct experience developing clinical regulatory strategies and submissions to effectively manage labelling for global markets and post-approval changes and optimizations for commercial vaccines. Demonstrated record identifying clinical and regulatory risks and developing strategies and/or contingencies for mitigation. Experience translating and integrating contemporary regulatory intelligence into appropriate internal policies and practice. Competencies and Skills: Articulate oral and written communication skills Active listening Strategic and tactical critical thinking Constructive operational productivity Adaptability Flexible and optimistic demeanor Reports to: SVP, Regulatory Affairs &nbsp; Location: Visp, Switzerland or Zug Switzerland &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Hourly Range: CHF 113.67 - CHF 132.61 &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Executive Director, Regulatory Affairs (Contract) – Clinical European/Global Focus

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: VAX-31 is an extremely complex biological product whereby numerous (31) Drug Substances are presented as an adjuvanted suspension Drug Product (DP). The complexity of the DP necessitates careful consideration for development of a pre-filled syringe (PFS) combination product for clinical and commercial use. Vaxcyte is looking for an energetic and talented individual to join our Drug Product Development Team to drive this combination product through the development and regulatory stage gates required for commercial success and distribution. The Vax-31DP is a suspension system, which generates a unique set of challenges for production, handling and testing. All these complexities present themselves within the combination device setting, and the incumbent will be tasked with managing these through their own team and within a matrix format through the wider DP/commercial organization. In addition, these complexities need to be understood, managed and presented to the regulators in convincing and coherent regulatory submissions. Because of these complexities, experience in the vaccine space, particularly adjuvanted vaccines would be a distinct advantage. This is an SME position which is suited for someone who has significant late-stage experience in leading the technical combination product workstream for a PFS/biologic combination product.&nbsp; Experience with combination product design control requirements and generation of associated documentation is required. As a core member of the DP Technical Team they will work closely with MSAT, CMO, Supply Chain, QC,&nbsp; QA and Clinical teams to ensure the appropriate Device Design requirements, including formal verification testing are met for use in clinical studies and global marketing submissions. They will work closely with the Regulatory and Quality teams to ensure the appropriate 21 CFR Part 4 and 820.3 compliant documentation is produced to support both clinical studies, marketing applications and continued commercial life cycle management. This is a unique opportunity to be involved in arguably the most complex Drug Product to enter clinical testing and commercial readiness, be a crucial part of late stage enablement and long-term commercial success, which will affect millions of lives globally. Essential Functions: Lead combination device development activities through clinical development, tech transfer, commercial manufacturing, registration, launch and post market surveillance. Guide the DP team on the necessary technical/CMC requirements for compliance with 21 CFR Part 4 and Part 820.3 and implement into the Combination Product program plan. Responsible for development of design control documents and maintaining design history file (DHF) and Device Master Record (DMR) for the Vax-31 vaccine product. Collaborate with internal cross-functional teams and external partners to develop and execute device specific plans to ensure clinical and launch milestones are met. Manage suppliers, device testing labs and Human Factors Engineering partners for ensure successful design verification and validation studies. Interact with the DP Technical Team and advise on late-stage development strategies for successful execution of Process Characterization studies and PPQ campaigns. Support the DP Technical Team in tech transfers of the process(es) for both late and early-stage programs to CMOs. Design and execute submission strategies for device related dossier components and support regulatory CMC activities. Requirements:&nbsp; PhD with minimum 10+ years, MS with 12+ years, or BS with 16+ years of leadership experience in the development and manufacturing of injectable combination products. Experience leading device development projects in a cross functional matrix organization from concept, development through commercialization. The candidate should have significant experience in managing and executing Design Control programs with biological molecules for combination products (drug device combo*), preferably Pre filled Syringe. Experience with PCV/adjuvanted vaccines would be a distinct advantage. Experience of manufacturing within GxP environments either directly or through CMOs . Preferred experience in late-stage DP development, designing and executing PPQ protocols, ensuring that drug product manufacturing processes are robust, reproducible, and meet regulatory requirements. This would include conducting risk assessments, identifying critical process parameters, and overseeing process validation activities for suspension DPs. The candidate should have a track record of working seamlessly within and across Teams and Organizations to execute the Design Control process. Strong scientific leadership is required: critical thinking, ability to present complex data sets and to independently propose and design follow-up studies. Lead, mentor and develop organization on device development best practices and strategies High degrees of both flexibility and organizational skills as well as an eagerness and ability to learn in order to effectively navigate multiple projects and timelines. Strong interpersonal skills; ability to communicate effectively both verbally and in written formats are necessary to collaborate effectively with the rest of the Formulation and DP technical team and well as across other teams. Reports to: Executive Director of Formulation &amp; Drug Product Development &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $219,000 - $256,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Device Development and Commercialization Lead

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Associate Director, Clinical Data Management (CDM) will provide hands-on support for the execution of clinical data management activities across our clinical programs, from study start-up through study closeout, ensuring high quality data deliverables. This is a hands-on position that will include supervising additional CDM resources at Vaxcyte, based on the number of clinical trials in development. The Associate Director, Clinical Data Management will be responsible for the oversight and management of our Biometrics partners related activities conducted for clinical trials conducted by Vaxcyte, from study start-up through to study closeout, ensuring high quality data deliverables which are on time and within budget. Essential Functions: Supports the oversight for the execution of data management for all programs and studies; accountable for data management activities for a program. Clinical Data Management Strategy Support the implementation of CDM strategies aligned with Vaxcyte’s goals and clinical research best practices, including feedback into CDM system development and optimization as well as study data collection, reviewing, and reporting. Continuously improving data management processes and workflows to increase efficiency, data quality, and team productivity. Assist in establishing clinical data standards and processes to ensure consistency and quality across all Vaxcyte studies. Help develop CDM departmental SOPs and ensure staff adherence to company policies, SOPs, federal guidelines and GCPs. Track department budget both for external and internal spend. Supports data management activities for regulatory submissions. Study-Specific Data Management Execute study-specific data management and data quality plans and support documentation (data transfer specifications, data review/reconciliation plans, database lock plans, etc.) as required across the data lifecycle for various data sources (e.g., eCOA, etc.) Serve as a data management subject matter expert (SME) and primary point of contact. Ensure study-specific data management practices align with applicable regulatory requirements (e.g., GCP, FDA, GDPR). Oversee the end-to-end data lifecycle across studies, including development of CRFs and CRF guidelines, database setup, data quality validation. Lead data review, including query management, and activities required for interim and final database locks, ensuring high quality. Execute operational data management plans across studies to ensure on-time delivery of all study data. Ensures data management documentation is filed/archived according to applicable company and regulatory requirements. Reviews clinical study related documents from a data management perspective (e.g. protocol) and approves data management specific documents (e.g. Data Management Plan, Data Review Plan, CRF Completion Guidelines, etc.). Assist with tracking of status of data management related activities (e.g. EDC setup, data cleaning, coding, etc.). Assist with final sign off of project and study-related documents including, Edit Check Specifications, CRF Completion Guidelines, Data Transfer Agreements, etc.&nbsp; Cross-functional Collaboration Collaborate seamlessly with internal teams, including Clinical Operations, Clinicians, Biostatistics, Project Management, and Patient Recruitment, Enrollment, &amp; Engagement, to ensure successful study execution. Collaborate with Quality &amp; Regulatory and other internal/external experts (e.g., privacy, legal) to maintain compliance with relevant regulations and reporting/disclosure expectations and stay informed of evolving standards and focusing on continuous process improvement within clinical trial data management. Effectively represent data management at project review meetings, quality review meetings, and other stakeholder meetings. Assist clinical study team with the planning, preparation, and on-site support of investigators meetings and CRA trainings. Provides oversight for Biometrics, Data Management CROs, EDC, and other third-party vendors who provide clinical study data to ensure compliance with the protocol, external/internal procedural standards, GCP, applicable regulatory guidelines, company policies, SOPs and other relevant guidelines. Fostering a culture of innovation and continuous improvement in clinical data management practices. Support onboarding of new CDM employees Requirements:&nbsp; BA/BS in life sciences, technical or health-related field, with a minimum of 10 years of pharmaceutical industry experience or CRO with duties of varying complexity.&nbsp; Experience in clinical trial database build, case report form design and familiar with CDISC and regulatory requirements. Excellent oral and written communication skills, project and personnel management skills and organizational skills. Experience in developing, implementing, and overseeing data management plans and quality plans for multiple concurrent research studies. Experience in development of database specifications and build, CRF design, and CRF guideline design, as well as traditional clinical data management systems and/or electronic data capture (EDC) platforms. Understanding and strategic knowledge of FDA and ICH regulations and industry standards applicable to data capture and data management processes. Familiarity with CDISC standards (SDTM, ADaM, CDASH) is required. Familiarity with emerging technologies in clinical research, including AI/ML applications is a plus. Excellent project management, communication, and problem-solving skills. CCDM is strongly preferred Reports to: Sr. Director, Clinical Data Management &nbsp; Location: Remote - US or San Carlos, CA&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $180,000 - $210,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Clinical Data Management

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our analytical development team. The primary responsibilities for the successful candidate will include method development, sample testing, analyzing data, and authorizing protocols and reports. Essential Functions: Assist in analytical method development of new assays. Perform analytical testing, data analysis and present in team meetings. Maintain thorough and accurate records of laboratory work. Support daily lab operations, sample inventory and sample shipment. Author analytical documents including but not limited to test method, protocols, and reports. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 2+ years of relevant industry experience, or MS with 1+ years of experience. Other combinations of education and/or experience may be considered. Experience in chemical and biological assays such as colorimetric/ fluorometric microplate assays, PCR/qPCR, HPLC, CE, UV-Vis, ELISA and LC-MS. Understanding of basic principles of analytical method development/ validation/ qualification concepts. Attention to detail and excellent skills in record keeping/documentation. Strong interpersonal skills and ability to communicate effectively both verbally and in written formats. This position is a lab-based role and requires onsite presence. Reports to: Senior Scientist, Analytical Development, Raw Materials &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length:&nbsp;12 Months &nbsp; Hourly Range:&nbsp;$51.00 - $56.00 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Analytical Development, Raw Materials (contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Manager, Quality Assurance to support supplier oversight, audit management, and quality systems compliance. This role will lead and perform third-party audits, manage audit responses and CAPAs, and partner with Global Vendor Management and cross-functional teams to support supplier qualification, materials management, and quality agreements. The Manager, Quality Assurance will also contribute to the development and continuous improvement of quality systems and procedures to ensure compliance with cGMPs, regulatory requirements, and internal quality standards. Essential Functions: Audit Program Management Performs third-party audits, including notified bodies, vendor and contract manufacturing organization (CMO) audits, ensuring compliance with quality agreements and regulatory expectations. Lead audit observations response and CAPA implementation, ensuring timely closure and effectiveness verification. Collaborate with Global Vendor Management. Suppliers and Materials Management Involved in the process for new supplier’s introduction. Involved in topics related to materials management such as VCNs (Vendor change notification). Involved in the establishment of Quality Agreements and other required regulatory documentation according to cGMP. Represent QA at internal and external cross functional team meetings related to supplier, services and/or materials. Quality Systems and Compliance Review and approve internal and external documentation for compliance such as deviations, risk assessments, change controls, CAPAs related to supplier, services and/or materials. Develop, implement and maintain procedures and policies related to supplier, services and/or materials topics. Participate in process improvement projects. Interact with key stakeholders to develop solutions to complex issues while promoting quality standards of excellence. Requirements:&nbsp; BS or BA with minimum 5 years of Quality Assurance experience. Other combinations of education and/or experience may be considered. In-depth knowledge of GMPs, FDA/EMA regulations and ICH guidelines. Strong attention to detail. Significant auditing experience ((ASQ certification (CQA, CQE) or auditor certification preferred)). Materials and suppliers’ management experience. Excellent verbal, written, and interpersonal communication skills. Experience leading and contributing through influence and working in cross functional teams. Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Ability to adapt to changing priorities. Strong overall knowledge of biologics manufacturing processes and Quality Systems. Ability to travel up to 40%. Reports to: Sr. Manager, Quality Assurance, Quality Management Systems &nbsp; Location: Visp, Switzerland &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Assurance

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Manager Supplier &amp; Internal Auditor to support the Quality Assurance organization through the planning, execution, and management of supplier and internal audits. This role will be responsible for assessing compliance with applicable global regulations, industry standards, and internal quality systems to ensure the integrity of Vaxcyte’s operations and external partnerships. The ideal candidate is a certified auditor with strong working knowledge of GMP, GLP, GCP, ICH, and ISO 13485 requirements and experience auditing within the pharmaceutical, biotechnology, or medical device industries. Essential Functions: Supplier Audits Plan, schedule, and conduct supplier audits (on-site and remote) in support of supplier qualification and ongoing oversight programs. Evaluate supplier compliance with applicable regulations, standards, and contractual quality requirements. Prepare audit agendas, audit reports, and documentation in accordance with internal procedures and regulatory expectations. Review and assess supplier responses to audit observations, including corrective and preventive action (CAPA) plans, and verify effectiveness. Collaborate with cross-functional stakeholders (e.g., Technical Operations, Supply Chain, Regulatory, Quality Systems) to assess audit findings and risk. Internal Audits Execute internal audits of quality systems and operational processes to assess compliance with GMP, GLP, GCP, ICH, ISO 13485, and internal policies and procedures. Support the development and maintenance of the internal audit program, including risk-based audit planning and scheduling. Identify compliance gaps, trends, and opportunities for continuous improvement. Document audit observations clearly and objectively and support follow-up activities to ensure timely and effective remediation. Compliance &amp; Quality Systems Ensure audit activities are conducted in accordance with applicable regulatory requirements and industry best practices. Support inspection readiness by maintaining audit documentation and providing audit support during regulatory inspections as needed. Contribute to the development, review, and improvement of quality procedures related to auditing, supplier management, and compliance. Provide guidance and training to internal stakeholders on audit processes, regulatory expectations, and compliance requirements. Requirements:&nbsp; Bachelor’s degree in Life Sciences or a related field. 5+ years of experience in Quality Assurance, auditing, or compliance within the pharmaceutical, biotechnology, or medical device industry. Other combinations of education and/or experience may be considered. Current auditor certification (e.g., ASQ Certified Quality Auditor (CQA) or equivalent). Strong working knowledge of GMP, GLP, GCP, ICH guidelines, and ISO 13485 requirements. Demonstrated experience conducting supplier and/or internal audits. Strong written and verbal communication skills, with the ability to clearly document audit observations and communicate risk. Excellent organizational skills, attention to detail, and ability to manage multiple audits and priorities. Ability to work independently while collaborating effectively in a cross-functional environment. Ability to travel. Reports to: Sr. Director, Global Quality Management Systems &amp; Compliance &nbsp; Location:&nbsp;San Carlos, CA; Open to remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $153,000 – $178,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Supplier & Internal Auditor

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a talented and experienced Engineer I/II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte. The successful candidate will have the following skills and qualities: Hands-on experience operating and maintaining bioreactors, including Ambr® 250, at laboratory scale. Experience with pilot scale fermentation and recovery equipment is a plus. Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization. An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals. Strong organizational and planning skills. Essential Functions: Lead operational activities related to bioreactor set-up, monitoring, harvest, and maintenance. Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls. Provide engineering support for design, implementation, and qualification of scale-down models. Author SOPs (standard operating procedure), process flow diagrams and batch records. Analyze and present fermentation data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks. Requirements:&nbsp; BS in Chemical Engineering or a related discipline with 8+ years, MS with 4+ years, or PhD with 0-2 years of relevant Pharma/Biotech industry experience. Hands-on experience with fermentation and/or primary recovery unit operations. Good understanding in fundamentals of bioreactor design, operation and controls. Strong knowledge of aseptic techniques Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration, is a plus Understanding of fermentation scale up and development of scale down models Familiarity with DoE (Design of Experiments) principles and software. Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus. Reports to:&nbsp;Senior Scientist, Upstream Development for Protein Development &amp; Manufacturing &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Expected Contract Length:&nbsp;12 months &nbsp; Hourly Range:&nbsp;$62 - $69&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Engineer I, Upstream Development for Protein Development and Manufacturing (Contract)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: This leadership role is responsible for developing and implementing global regulatory strategies for clinical investigational studies and commercialization of vaccines for both adult and pediatric populations.&nbsp; In collaboration with Clinical Development and Safety this role is responsible for regulatory guidance that enables and facilitates the preparation of clinical development protocols, interpretation and summary of clinical results, initiation, development and preparation of clinical and pre-clinical regulatory documents, correspondence and responses to regulatory authorities toward commercial regulatory approval of novel vaccine products.&nbsp; The role requires experience developing and implementing regulatory strategies for vaccines and preparing investigational and commercial regulatory applications, i.e., IND/IMPD, BLA/MAA, post-approval clinical and safety notifications and global regulatory approvals.&nbsp;&nbsp; Strong communication skills, in particular, the ability to distill complicated issues and regulatory risks and effectively articulate options and opportunities for reconciliation, are essential.&nbsp; The Executive Director must be comfortable with interfaces at all levels of the organization, including senior leadership, Level 1 – 4 multi-disciplinary teams, and with external partners, CDMOs/CROs and regulatory authorities.&nbsp;&nbsp; The ideal candidate possesses a clinical background in vaccine development and relevant experience in development and execution of clinical protocols.&nbsp; Regulatory experience including a thorough understanding of global regulatory requirements and expectations, and the ability to influence and shape regulatory strategies in a dynamic environment is imperative.&nbsp; Strategic vision, attention to detail, and a passion for regulatory excellence are key attributes for success in this position. Essential Functions: Develop and execute globally viable clinical regulatory strategies. Develop, author and review regulatory CMC documentation for submission including application documents, correspondence and responses to queries. This includes requests for scientific advice in EU, Switzerland, UK and Canada, etc.&nbsp; Provide regulatory guidance for L2, L3 and L4 cross functional development teams. Ensure adherence to current regulatory requirements and alignment with appropriate regulatory guidance (including ICH) and industry best practices. Serve as a primary point of contact with regulatory authorities, i.e., FDA, EMA, MHRA, PMDA, Health Canada, etc., as appropriate. Contribute to the development of product label claims and justifications for clinical outcomes. Lead interactions and negotiations w/global regulatory authorities for reconciliation of specific clinical and pre-clinical issues to expedite regulatory application submissions and approvals. Support regulatory requirements for safety/pharmacovigilance notifications to regulatory authorities. Provide guidance on contemporary regulatory intelligence, statutory legislation and changes in regulatory authority requirements and expectations. Manage cross-functional teams to demonstrate and ensure regulatory compliance. Optionally, people development and management may be expected. Requirements:&nbsp; BA or BS in a relevant scientific or technical discipline, i.e., clinical pharmacology, immunology, biology, medicine, bioanalytics or related life sciences, is required with 15+ years industry experience that demonstrates technical and regulatory expertise and competence.&nbsp; Graduate education and/or professional certifications or training in regulatory and/or quality are a bonus. Other combinations of education and/or experience may be considered 10+ years of extensive and relevant regulatory experience with a proven record of achievement in developing and prosecuting regulatory submissions and application approvals within the pharmaceutical or biotechnology industry with a particular emphasis on vaccines and clinical content. A thorough understanding of clinical development, statistics with particular experience with vaccine development and commercialization. Direct experience engaging multiple health authorities, i.e., FDA, EMA, MHRA, Health Canada, etc., and preparation of regulatory applications for global health authorities.&nbsp; Demonstrated ability to lead and manage cross-functional teams, developing and establishing regulatory strategies and preparing regulatory applications including review and submission of clinical and pre-clinical documentation to regulatory authorities. Direct experience developing clinical regulatory strategies and submissions to effectively manage labelling for global markets and post-approval changes and optimizations for commercial vaccines. Demonstrated record identifying clinical and regulatory risks and developing strategies and/or contingencies for mitigation. Experience translating and integrating contemporary regulatory intelligence into appropriate internal policies and practice. Competencies and Skills: Articulate oral and written communication skills Active listening Strategic and tactical critical thinking Constructive operational productivity Adaptability Flexible and optimistic demeanor Reports to: SVP, Regulatory Affairs &nbsp; Location: Remote - US &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $299,000 - $349,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Executive Director, Clinical Regulatory

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a Senior Director, Launch Lead, VAX-31, to lead strategic planning and execution of the company’s first launch of VAX-31. This role will coordinate cross-functional activities from late-stage development through market entry, ensuring readiness across supply chain, regulatory, medical affairs, commercial operations, communications, and other functions. The position will partner with senior leadership to define launch strategies, manage timelines, mitigate risks, and drive alignment across internal and external stakeholders to deliver successful product introductions globally. Essential Functions: Drive cross functional launch delivery of VAX-31 and oversee integrated launch plans. Ensure alignment with corporate objectives and market requirements. Develop and maintain comprehensive launch readiness frameworks, including working with supply chain, manufacturing scale-up, regulatory approvals, labelling, distribution, and commercial execution. Partner with Commercial, Medical Affairs, Regulatory, Quality, Manufacturing, Finance, Market Access, and Scientific Affairs teams to ensure seamless coordination and timely decision-making. Facilitate cross-functional launch meetings, track critical milestones, and proactively identify risks and contingency plans. Drive post-launch performance tracking and lessons learned to inform future launches. Champion best practices in pharmaceutical launch project management, including governance models, risk registers, and stakeholder engagement strategies. Requirements:&nbsp; BA/BS in life sciences, engineering, or business; advanced degree preferred. At least 15 years in pharmaceutical or biotechnology industry, with at least 5 years in launch related project management or product marketing/management; vaccine launch experience strongly preferred. Ensure adherence to project scope, budget, and schedule; ensure the alignment of the project to corporate strategic direction, resource allocation, and management decision-making. Facilitate team meetings, cross-functional communication, and decision-making; ensure alignment with internal and external stakeholders, program and project teams and functional area partners. Support continuous improvement efforts in Project Management practices at Vaxcyte. Proven track record of leading successful product launches in multiple markets. Expertise in cross-functional leadership, strategic planning, and risk management for complex launches. Strong understanding of regulatory pathways, supply chain logistics, and market access considerations. Thorough understanding of product development activities in biotech/drug/vaccine development, including key interdependencies, and knowledge of proven development strategies and tactics. Demonstrated strong organizational and strategic leadership skills. Demonstrated aptitude for successfully managing multiple projects, of varying complexity, within the specified guidelines, timeframes, and budgets. Self-starter with the ability to work independently, deal with ambiguity, and execute. Expert planning and tracking skills, well-organized, focused on results, capable of managing multiple projects with respect to priorities and self-management. Proven influence management and communication skills, at all levels of the organization. Expert knowledge of MS Word, Excel, PowerPoint, Visio, and Project. Excellent written and oral communication skills. Other combinations of education and/or experience may be considered. Reports to: Chief Commercial Officer &nbsp; Location: Boston, MA or Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $271,000 - $316,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Product Launch Lead VAX-31

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a Vice President of Marketing to lead our marketing strategy as we prepare to become a U.S. commercial vaccine company within the next 18 months. This role is critical to shaping our U.S. launch, building the marketing foundation for a first commercial product, and positioning the company for future global expansion. The ideal candidate brings deep vaccine marketing experience, a strong understanding of the U.S. immunization landscape, and a proven track record of leading pre-launch and launch activities in a highly regulated environment. This leader will balance strategic vision with hands-on execution, building capabilities, teams, and processes appropriate for a first commercial launch. This individual should have demonstrated experience driving commercial demand across target audiences—including healthcare providers, consumers/patients, payers, and public health stakeholders—with a particular emphasis on consumer engagement strategies that build disease awareness and motivate vaccination behavior. Essential Functions: U.S. Launch &amp; Commercial Strategy Lead the development and execution of the U.S. marketing strategy for our initial vaccine launch, including disease awareness, brand positioning, and go-to-market planning. Develop differentiated value propositions grounded in clinical data, public health impact, and real-world evidence. Partner closely with the Chief Commercial Officer to align marketing strategy with overall commercial, sales, and market access plans. Vaccine &amp; Immunization Expertise Apply deep understanding of the U.S. vaccine ecosystem, including immunization schedules, CDC/ACIP considerations, public health stakeholders, and provider types. Design marketing strategies that address the unique dynamics of vaccine adoption, including site-of-care complexity, and public trust. Collaborate with Medical Affairs and Regulatory to ensure compliant, scientifically sound communications. Partner with Government Affairs and Policy teams to ensure marketing strategies account for evolving immunization policy, public funding mechanisms, and advocacy stakeholder dynamics. Collaborate with HEOR and Market Access to develop evidence-based value narratives and payer-facing materials that support formulary positioning and access. Brand &amp; Portfolio Marketing Establish the company’s commercial brand and narrative as we transition from a development-stage biotech to a commercial organization. Lead brand development, messaging, and omnichannel promotional strategy across HCP, payer, and patient audiences. Design and execute integrated omnichannel engagement strategies spanning personal promotion, digital channels, and non-personal promotion to optimize customer reach, frequency, and impact across the vaccine adoption journey. Develop digital-first engagement models for hard-to-reach HCP segments, including pharmacists and public health practitioners critical in vaccine delivery. Develop and execute consumer/patient engagement strategies—including disease awareness campaigns, direct-to-consumer (DTC) advertising, and health literacy initiatives—that drive vaccination demand at the population level. Build multi-audience demand generation strategies that create a pull-through effect across HCPs, consumers, payers, employers, and public health decision-makers to maximize vaccine adoption. Partner with Patient Advocacy organizations and community health stakeholders to inform patient-centric messaging and overcome barriers to vaccination, including vaccine hesitancy and health equity gaps. Develop lifecycle and indication expansion strategies to support future growth and pipeline advancement. Market Insights &amp; Analytics Lead market research, customer insights, and competitive intelligence to inform launch readiness and ongoing optimization. Define KPIs and performance metrics to measure marketing effectiveness and launch success. Leverage data analytics and AI-powered tools to enhance competitive intelligence, identify prescriber behavior patterns, and inform real-time marketing optimization decisions. Team, Infrastructure &amp; Capability Building Build and lead a high-performing marketing organization, scaling the team and capabilities over time. Establish agency partnerships and external vendors to support launch execution. Build and manage a high-performing agency roster with clear scopes of work, performance metrics, and governance structures that drive accountability and cost efficiency. Implement marketing processes, governance, and operating models consistent with U.S. commercial and regulatory requirements. Implement marketing operations infrastructure including project management systems, digital asset management (DAM), and content supply chain processes designed for scale and speed-to-market. Own the marketing budget, ensuring disciplined resource allocation across brand, digital, and promotional investments with clear ROI measurement and launch investment frameworks. Future Global Expansion Design U.S. marketing strategies with future global scalability in mind. Partner cross-functionally to support early planning for potential international expansion, including global brand frameworks and knowledge transfer. Digital Innovation &amp; AI-Enabled Marketing Champion the integration of AI and emerging technologies into marketing workflows to improve quality, speed, cost efficiency, and decision-making across the marketing organization. Evaluate and deploy AI-powered tools for content creation, personalization, competitive intelligence, and customer engagement—ensuring all applications comply with regulatory and MLR requirements. Leverage generative AI to accelerate content development cycles, enable omnichannel personalization at scale, and streamline the Medical-Legal-Regulatory (MLR) review process. Establish an AI-informed marketing operations model that uses predictive analytics to optimize targeting, message sequencing, and media mix allocation. Identify opportunities to use AI and automation to reduce agency costs, accelerate time-to-market for promotional materials, and improve ROI across marketing investments. Partner with IT, Data Science, and Commercial Operations to build a connected, data-driven marketing ecosystem from the ground up. Requirements:&nbsp; Bachelor’s degree required; advanced degree (MBA, MS, PhD) preferred with 15+ years of progressive marketing experience in biotech or pharmaceuticals. Other combinations of education and/or experience may be considered Significant experience in vaccine marketing, including U.S. launch experience. Demonstrated success leading pre-launch and first-launch marketing efforts. Preferred Qualifications: Experience building a marketing organization in a pre-commercial or first-launch biotech environment. Track record of leading omnichannel marketing strategies integrating digital, non-personal, and field-based promotion. Experience managing complex agency rosters and marketing vendor ecosystems across creative, media, digital, and analytics functions. Familiarity with AI/ML applications in marketing, including content generation, customer segmentation, predictive analytics, and campaign optimization. Demonstrated fluency in marketing analytics, including KPI frameworks, attribution modeling, and data-driven optimization. Experience with MLR processes and demonstrated ability to partner effectively with Medical and Legal/Regulatory in a compliant promotional environment. Strong executive presence with the ability to influence C-suite stakeholders and represent the marketing function on cross-functional leadership teams. Proven experience driving commercial demand generation across both HCP and consumer/patient audiences in a regulated healthcare environment, including DTC, disease education, or unbranded awareness campaigns. Public health marketing or disease awareness campaign experience preferred Reports to:&nbsp;Chief Commercial Officer &nbsp; Location: San Carlos, CA / US Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $315,000 - $385,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is not eligible for relocation assistance.&nbsp; &nbsp; #LI-JN1We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Vice President, Marketing

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is undergoing a major ERP transformation, moving to SAP S/4HANA to support its rapid growth and upcoming transition to Commercial Operations. The IT SAP Supply Chain Senior Business Systems Analyst (BSA) will play a critical role in bridging Supply Chain and IT, ensuring successful implementation, stabilization, and ongoing optimization of SAP S/4HANA Supply Chain capabilities. This position requires strong functional expertise in SAP Supply Chain functionalities, deep understanding of contract manufacturing processes, and experience in complex ERP implementation projects. Essential Functions: Support the implementation and stabilization of SAP S/4HANA Supply Chain modules in a regulated environment. Collaborate with Supply Chain, Manufacturing, Quality, and IT teams to design future-state processes aligned with Vaxcyte's CDMO business model. Assist in data mapping, migration, cleansing, and validation during cutover and post-go-live activities. In-depth knowledge of SAP S/4HANA systems and integration techniques with third-party planning systems. Expertise with agile methodology, global deployments, and data migration planning. Experience working in GxP validated and SOX regulated systems. Configure and maintain SAP Supply Chain modules including Materials Management (MM), Master Data, Subcontracting &amp; External Processing, Batch Management, and Forecast Consumption &amp; Demand Planning. Assist with the integration points with FI (Financial Accounting) &amp; CO (Controlling) Support end-to-end planning flows from demand through manufacturing and supply execution. Excellent verbal and written communication skills, with the ability to effectively communicate complex technical concepts to non-technical stakeholders. Work closely with Supply Chain stakeholders (Planning, Procurement, Finance) to capture requirements. Translate business needs into functional specifications for SAP configuration. Help develop and document business process flows. Support complex planning scenarios where capacity, lead times, and execution are controlled by external CDMO partners. Develop and execute test plans for SAP Supply Planning processes. Support User Acceptance Testing (UAT) and resolve issues promptly. Ensure validation readiness and maintain audit trail expectations in compliance with regulatory requirements. Training &amp; Change Management Create training materials and deliver sessions for Supply Chain users. Provide ongoing support post go-live. Ensure compliance with GxP standards and Life Sciences industry requirements. Requirements:&nbsp; Minimum of 7 years of experience as a BSA with SAP Supply Chain modules. Bachelor's degree in Supply Chain, Operations, Information Systems, or related field Strong analytical and problem-solving skills, with the ability to independently diagnose and resolve SAP supply chain issues in complex CDMO-based manufacturing environments. Experience in identifying and managing project risks, with a proactive approach to mitigation. Familiarity with change management principles and techniques to facilitate smooth transitions and adoption of new systems. Hands-on experience with SAP S/4HANA Supply Chain (implementation or migration projects preferred) and Fiori applications. Proven experience supporting SAP-based contract manufacturing or CDMO operating models. Experience developing and mapping business process flows using Visio or similar tool. Strong understanding of Supply Chain processes and ERP implementation best practices. Excellent communication and stakeholder management skills. Solid experience managing SAP master data relevant to supply planning (materials, vendors, sourcing, BOMs). Other combinations of education and/or experience may be considered. Reports to: Director, IT Supply Chain Systems &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $163,000 - $190,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp; Relocation:&nbsp; This role is eligible for relocation assistance.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior IT Business Systems Analyst, SAP Supply Chain

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Director, Real-World Evidence &amp; Epidemiology to play a foundational role in executing, expanding, and maturing our epidemiology and real-world evidence (RWE) capabilities across the vaccine lifecycle. You will join a purpose-driven team advancing the science of prevention across the life course. This role offers a rare opportunity to help build an epidemiology and real-world evidence function from the ground up, with meaningful ownership, mentorship, and room to grow. This is a hands-on, high-impact role well-suited for an early-to-mid career epidemiologist who enjoys both doing the work and building the function. The role combines operational leadership (study start-up, vendor oversight, IRB submissions) with scientific execution, including study design, analysis, evidence synthesis, and interpretation. Over time, this individual will grow into a scientific epidemiology lead, taking on increasing ownership of study design, analytic strategy, and external scientific engagement. Essential Functions: Study Execution &amp; Operations Lead end-to-end execution of epidemiology and RWE studies, including retrospective database studies, prospective observational studies, and hybrid designs, supporting both pediatric and adult vaccine programs. Manage study start-up activities including contracting, budgets, timelines, and SOWs with CROs, academic partners, and data vendors. Oversee IRB and ethics submissions and ensure compliance with regulatory, privacy, and data governance requirements. Partner closely with Legal, Procurement, and Compliance to ensure timely and compliant study execution. Epidemiologic &amp; Analytic Contributions Contribute to study design, protocol development, and statistical analysis plans in collaboration with internal scientific partners. Conduct or oversee hands-on analyses using real-world data sources (e.g., claims, EHR, surveillance systems), including data quality checks and exploratory analyses. Support and/or lead retrospective analyses, prospective cohort studies, systematic literature reviews, and meta-analyses relevant to pneumococcal disease and vaccine effectiveness across age groups. Work with large datasets and analytic tools (e.g., SAS, R, STATA) to support internal analyses and to critically review and interpret CRO-generated outputs. Evidence Synthesis &amp; Scientific Communication Lead or contribute to abstracts, manuscripts, white papers, and conference presentations. Translate complex scientific and epidemiologic findings into clear, actionable insights for diverse internal audiences, including commercial partners, medical science liaisons, HEOR, legal, and regulatory teams. Support consistent, high-quality interpretation of evidence across Vaxcyte’s epidemiology and RWE portfolio. Capability Building &amp; Growth Help establish best practices, templates, and SOPs for epidemiology and RWE study conduct. Build strong working relationships with academic collaborators, public health partners, and external vendors. Gradually assume greater scientific leadership and ownership of the epidemiology portfolio as the function grows. Requirements:&nbsp; Master’s degree in Epidemiology, Public Health, Biostatistics, or a closely related field, with 8 years of experience in epidemiology, real-world evidence, or observational research within biotech, pharma, academia, public health, or a CRO required. PhD or DrPH in Epidemiology or a related discipline with 6 years experience preferred. &nbsp;Other combinations of education and/or experience may be considered. &nbsp; Demonstrated experience planning and executing observational studies, including retrospective and/or prospective designs. Experience working with real-world data and analytic tools (e.g., SAS, R, STATA), including data management, analysis, or close oversight of analyses. Ability to clearly present complex scientific and epidemiologic data to non-technical audiences, both verbally and in writing. Strong scientific judgment, organizational skills, and ability to independently manage multiple workstreams in a fast-paced environment. Highly desired experience: Prior experience at the CDC, including Epidemic Intelligence Service (EIS) or similar applied epidemiology training programs. Experience conducting or contributing to systematic literature reviews and meta-analyses. Experience working with large healthcare databases (e.g., claims, EHR, surveillance systems). Prior experience in vaccine research, infectious disease epidemiology, or respiratory disease. Track record of contributing to peer-reviewed publications and major scientific meetings. Prior experience with health economic modeling Interest in growing into a scientific leadership role within industry. Reports to: Vice President, Scientific Affairs &amp; Epidemiology &nbsp; Location: San Carlos, CA/ Remote (East Coast Region)&nbsp; &nbsp; Compensation:&nbsp; The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $199,000 – $232,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Real-World Evidence & Epidemiology

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our Analytical Development team as a contractor. Primary responsibility for the contractor will be to support the developmental activities currently on going in the laboratory as assigned. Essential Functions: Maintain an organized and efficient laboratory workspace for the team. Primary responsibility to oversee the organization of chemical inventory, ensuring proper labelling, storage, and compliance with safety regulations. Assist in the organization and labelling of materials stored in freezers and refrigerators, ensuring easy access, proper storage and handling of samples and materials. Support daily lab operations, including sample inventory and sample shipment. Assist in the collection, labelling, and preparation of samples for analysis. Prepare reagents and solutions according to established protocols. Perform routine analytical testing by following established protocols, ensuring accurate execution of tests and documentation for proteins and carbohydrates including: Microplate assays including enzymatic assays and colorimetric assays such as Bradford, Lowry and etc HPLC- Especially SEC and RP-HPLC with experience in Chemstation CE and iCIEF – Especially with Protein Simple or PA-800 systems Keep accurate and detailed records of experiments. Maintain an accurate inventory of chemicals and reagents, tracking usage and expiration dates. Coordinate the ordering and restocking of laboratory supplies as needed. Perform routine analytical testing by following established protocols, ensuring accurate execution of tests and documentation. Collaborate within a team environment to support and further team objectives. Demonstrate flexibility and effectively complete assigned tasks with high quality and in a timely manner. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 0-2 years of relevant industry experience. Experience with lab inventory chemical inventory, ensuring proper labelling, storage, and compliance with safety regulations Ideal candidate will have a background in analytical chemistry principles and hands-on experience with modern analytical instrumentations commonly used in the analysis and characterization of drug candidates. Candidates with other scientific disciplines may be considered based on relevant experience. Experience in chemical and biological assays such as colorimetric/fluorometric microplate assays and HPLC. Experience working with protein analysis – UV-Vis, CE, Bradford Assay or ELISA. Understanding of basic principles of analytical method development/ validation/ qualification concepts. Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data. Strong interpersonal skills: ability to communicate effectively both verbally and in written formats. Ability to work under supervision and independently in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease. Reports to: Manager, Analytical Development &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Expected Contract Length: 6months &nbsp; Hourly Range: $40.00/hr. – $45.00/hr. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist I (contract), Analytical Development for Characterization

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking a talented and experienced Executive Assistant to provide administrative support to the Chief Commercial Officer. The ideal candidate has a natural passion for learning, enjoys taking on new tasks and projects, has an eye for perfection, and excels in an energetic, fast-paced environment while being able to understand big picture needs. This individual must be a self-starter, who is proactive, well-organized, anticipates needs and prioritizes tasks, and has a high degree of poise, emotional intelligence and professionalism. Strong business judgment with excellent communication skills is essential. The candidate will be a strategic partner bringing everything together, from calendaring and travel, team support, and prioritizing workflows. Essential Functions: Optimize and ensure Executive’s preparation and effectiveness. Arrange and manage all aspects of travel for the executive, including flights, hotels, ground transportation, and detailed itineraries. Process and manage Executive’s expense reports. Proactively and strategically manage Executive’s calendar, prioritize and update based on solid understanding of the context for requests. Understand and help prioritize key strategic initiatives and tasks; assist Executive in managing and addressing outstanding to-dos and requests. Represent Vaxcyte and develop relationships with several external constituents. Attend important meetings, take detailed minutes, and distill critical takeaways from discussions. Provide the Executive with a concise summary and actionable plan, ensuring timely follow-up on all assigned action items. Collaborate with Executive to manage strategy for and calendaring of Executive’s direct report 1x1 meetings, skip-level meetings, leadership team meetings, among others. Collaborate with the Executive Assistant team across Vaxcyte to ensure alignment of schedules, internal and external events. Keep a pulse on daily agendas and proactively prioritize – planning days in advance to ensure the right information, people, etc. are prepared and engaged. Build cross-functional relationships at all levels of the Company to ensure understanding of the business, leaders and workflow. Develop an understanding of the team and field requests from all contacts, making a point to be available and approachable. Highly motivated and proactive, with the ability to work independently, anticipate needs, and take initiative to solve problems in a fast-paced environment. Ability to maintain confidentiality and handle sensitive information discreetly. Demonstrate composure and flexibility, regardless of competing priorities. Find new and efficient ways to create work processes to help maximize your executives' time, including weekly reporting, goal-tracking and team meetings. Requirements:&nbsp; Bachelor’s Degree with 10+ years’ experience in an administrative role supporting a C-level Executive. Commercial support experience is a significant plus. Experience in life sciences/biotech companies a plus. Ability to respond to and support occasional off-hour requests given public company executive and investor relations aspects of role. Advanced knowledge of MS Office including Outlook, Word, Excel and PowerPoint; strong calendar and travel management skills and experience. Strong interpersonal skills, with excellent written and verbal communication skills. Ability to effectively communicate with people at all levels and from various backgrounds. Versatility, flexibility, resilience and a willingness to work within constantly changing priorities with passion and enthusiasm. Commitment to excellence and high standards with attention to detail. Strong organizational, problem-solving and analytical skills; able to manage priorities and workflow. Reports to: Chief Commercial Officer Location: Boston, Massachusetts Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $127,000 - $148,000 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Executive Assistant

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Scientist II (contract), Research, to support the research and development of a novel bacterial polysaccharide conjugate vaccine. Specifically, this role will contribute to the setup, synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates.&nbsp; The ideal candidate will have an excellent understanding of conjugation process development, analytical chemistry principles, and substantial hands-on laboratory experience. The successful candidate will be expected to independently optimize and troubleshoot upstream and downstream conjugation processing procedures with minimal guidance. The candidate will also contribute across a range of related areas, including analytical development, stability studies, and process optimization initiatives. Responsibilities will also include record management, presenting data at group meetings, and contributing to the authorship of laboratory protocols and development reports. Essential Functions: Set up, optimize, and troubleshoot multi-step syntheses of protein-polysaccharide conjugates using click-chemistry and other related chemistries. Purify polysaccharides and conjugates using a variety of methods, including dialysis, FPLC chromatography, and tangential flow filtration (TFF). Characterize protein/polysaccharide/conjugates using different analytical methods, including SDS-PAGE gel, Western blotting, ELISA, HPLC, SEC-MALS, colorimetric and dynamic binding assays, et al. Apply Design of Experiments (DoE) principles; design, execute, and interpret statistically modeled experiments using DoE software. Proactively contribute scientific ideas, experimental strategies, and process improvements. Independently review and summarize relevant scientific literature to inform experimental design. Maintain highly organized records and Benchling entries to enable optimization and assessment of reproducibility. Analyze, interpret, and clearly communicate experimental data, including identifying trends, anomalies, and recommending next steps. Execute established protocols with limited oversight, demonstrating strong technical proficiency. Support team in routine laboratory activities and instrument maintenance. Requirements:&nbsp; BS. in Chemistry, Biochemistry, or related field or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience. Strong understanding of underlying scientific concepts, process development, and analytical assay principles. Extensive hands-on experience in purification methods such as diafiltration, depth filters, and TFF (required). Prior hands-on experience in the conjugation process development is highly desirable. Proficiency with common protein/polysaccharide/conjugates analytical techniques, including SDS-PAGE, Western blotting, ELISA, HPLC, and SEC-MALS, is required Proven track record of developing scalable processes suitable for the pharma/Biotech industry. Experience with vaccines, carbohydrates, or protein is a plus. Attention to detail and excellent organizational skills. Ability to contribute to the overall lab management, including organization of vendors, service contracts, and equipment maintenance. Demonstrated success working in a cross-functional team environment. Strong interpersonal skills, with excellent written and verbal communication skills. Reports to: Senior Manager, Research &nbsp; Location: San Carlos, CA Expected Contract Length: 12months&nbsp; Hourly Range:&nbsp;$51.00 - $56.00 We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II (Contract), Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Research team uses a broad palette of chromatographic tools to purify diverse vaccine antigens. Applicants must have practical, hands-on experience with multiple chromatographic modalities (not limited to monoclonal antibody/Protein A workflows). Experience should include selection, screening, development, scale-up and characterization of various chromatography techniques. Essential Functions: Execute the following AKTA FPLC chromatography techniques: Immobilized metal affinity chromatography (IMAC) Ion-exchange chromatography (IEX) Hydrophobic interaction chromatography (HIC) Size-exclusion chromatography (SEC) Hydroxyapatite (CHT / HA) Designing chromatography trains to reduce host cell protein, endotoxin and aggregates using complementary modalities Demonstrated DoE experience for multimodal optimization is a plus. Membrane chromatography for high-throughput contaminant removal or virus/VLP processing and as a scale-friendly polishing/scavenging step. Keep accurate and current records of development experiments and/or project related activities in an electronic laboratory notebook. Present data from experiments to the team and contribute to technical discussions. Work within a team environment and provides support as necessary to further the team’s initiatives. Requirements:&nbsp; BS in Biochemistry, Molecular Biology or a relevant science considered, with minimum of 5 years of relevant industry experience or MS with minimum of 3 years relevant industry experience. Experience with diverse protein targets, bacterial and eukaryotic recombinant proteins, small/large subunit vaccine antigens, fusion proteins, multimeric complexes, glycoproteins, and VLPs. The role requires demonstrated success with alternative capture/polishing methods and orthogonal cleaning strategies appropriate for potential vaccine antigens. Preferred experience with Cell-free protein synthesis system Familiarity with automation or high throughput workflows such as (96-well plates) and UNICORN/AKTA software DoE integrations. Experience in process development Strong interpersonal skills to collaborate well within the team and excellent written and verbal communication skills. Reports to: Scientist I, Research &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length: 12months &nbsp; Hourly Range: $56.00 – $62.00We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist (contract), Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Veeva Configuration Specialist IT role serves as a techno-functional expert for Vaxcyte’s current and future Veeva applications and related technologies. Working closely with business and managed services partners, this role is responsible for implementing, managing, and maintaining Quality, Regulatory and Clinical Veeva Vault system configurations. While technical in nature, this role drives business value by blending technology expertise with business process know-how. This is a hands-on role that reports to the Associate Director of Enterprise IT Systems at Vaxcyte’s San Carlos, California headquarters. Essential Functions: Customize and configure Veeva Vault applications to meet business requirements. This includes creating/updating custom doc types, objects, lifecycles, workflows, jobs, user roles, security management, reports and vault loader. Provide Veeva admin and operational support for issues impacting end-users, system unavailability, data integrity, and manage user account provisioning. Create and maintain system-specific IT documentation such as configuration forms, business processes, operating procedures, templates and design standards Establish and maintain close working relationships with internal Veeva business partners. Collaborate with stakeholders to understand current business processes and identify areas for improvement and optimization. Lead requirements gathering, analysis, design, and configuration activities. Assess impact and configure new features available after each Veeva release. Provide project management support for enhancement efforts. Follow GxP change management processes for system configuration changes and platform upgrades. Support periodic reviews and related compliance activities. Coordinate with managed services, business partners and assurance teams to implement planned releases and functional change requests. Requirements:&nbsp; Bachelor’s degree in computer science, information systems, or related field. Mandatory 3+ years of hands-on configuration experience with any Veeva Vault Platform systems. 5- 7 years of total IT Systems experience. Strong understanding of Veeva application suites including Quality (QualityDocs, QMS, Vault Training), RIM and Clinical eTMF. Experience with validated GxP environments including implementation, documentation and change management is a must. Extensive experience as a business systems analyst for Enterprise IT systems. Veeva system administration certification is a plus. As is/to be process mapping and analysis. Solid problem-solving skills and ability to troubleshoot issues including root cause analysis. Excellent communication skills and ability to work collaboratively with stakeholders. Technical writing skills for updating SOPs, WIs, Knowledgebase articles and documenting business processes. Reports to:&nbsp;Associate Director, IT Enterprise Systems &nbsp; Location: San Carlos, CA; Ability to be on-site 2 or 3 days per week &nbsp; Expected Contract Length:&nbsp;6 months &nbsp; Hourly Range:&nbsp;$66.38 - $77.45 (SF Bay Area). Hourly ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Veeva Configuration Specialist (Consultant)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Legal team is seeking a motivated, forward-thinking AI Consultant to support the design, evaluation, and implementation of emerging AI solutions across Legal and Compliance functions. This project-based role is ideal for a student pursuing their MS or PhD with strong technical skills, curiosity about legal operations, and a passion for applying AI to real-world business problems. You will work closely with cross-functional teams to prototype, test, and deploy AI tools that drive efficiency, enhance compliance workflows, and expand the team’s ability to deliver strategic support to the business. Essential Functions: Bot Development: Design and prototype an AI-powered chatbot to support Legal and Compliance functions (e.g., FAQs, SOP references, or workflow routing). Legal Dashboard Enhancements: Enhance the existing Legal Dashboard using Box AI and related integrations to improve automation, visibility, and user experience. Tool Evaluation: Research, evaluate, and recommend emerging AI tools and products; schedule and participate in demos; provide post-demo analysis and recommendations. Implementation Support: Assist with tool rollout, user onboarding, and training materials for Legal, Compliance, and other stakeholders. Continuous Exploration: Identify and scope new AI use cases within Legal and related functions, collaborating with IT and Operations as needed. AI Tool Integration: Support implementation and optimization of existing Legal AI tools such as Spellbook and CoCounsel to ensure full functionality and adoption across teams. System Connectivity: Collaborate with IT to integrate and connect AI tools and software applications, enabling seamless read-only and action-based access across platforms.&nbsp; Requirements:&nbsp; Enrolled in an MS or PhD program pursuing a degree in Computer Science, Data Science, Engineering, AI or a related field.&nbsp; Strong understanding of generative AI concepts (e.g., open-source small LLMs, MCPRAG and API integrations). Excellent communication and analytical skills. Ability to translate technical concepts into practical applications for non-technical teams. Experience using or configuring AI tools such as Box AI, Microsoft Copilot, ChatGPT Enterprise, or similar platforms is preferred. Prior exposure to automation tools or workflow design (e.g., Power Automate, Zapier, or custom bots) is preferred. Demonstrated project management or client-facing experience (internships count!) is preferred.&nbsp; Reports to: Sr. VP, General Counsel, Chief Compliance Officer &amp; Corporate Secretary &nbsp; Location:&nbsp;San Carlos; Open to Remote &nbsp; Expected Contract Length: 12-months (this is a part -time role that is project based) &nbsp; Hourly Range: $40.00 - $50.00 per hour (SF Bay Area). Hourly ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

AI Implementation Consultant – Legal

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Engineer II to contribute to the Polysaccharide Upstream Pilot Plant as this person will be responsible supporting design and execution of experiments at pilot scale of polysaccharide production and scale down model experiments of process operations, contributing towards the process characterization of the polysaccharide process.The successful candidate will have knowledge and practical laboratory upstream process experience in executing, supporting, or developing processes such as fermentation, clarification processes (centrifugation experience is a plus), and tangential flow filtration. In addition, the candidate must have experience in performing plate-based colorimetric assays (Bradford and Lowry assays are a plus). Essential Functions: Perform experiments for polysaccharide upstream process such as fermenters, centrifuges, depth filtration, and tangential flow filtration operations. Support media and buffer preparations for the experiments for execution. Perform assays needed to analyze the results of the experiment such as metabolite analysis for fermentation and colorimetric plate assays to determine concentrations of product and impurities through the operations. Assist in design and execution of upstream process development studies, including protocols and reports. Keep accurate and current records of development experiments and/or project related activities in an electronic laboratory notebook. Present data from experiments to the team and contribute to technical discussions. Work within a team environment and provides support as necessary to further the team’s initiatives. Requirements:&nbsp; BS in Chemical Engineering, Biochemistry, or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience. Strong experience with at least 2 upstream operations: single-use fermentors, centrifuges, depth filtration, and tangential flow filtration. Experience executing colorimetric plate-based assays and routine biological operations analyses such metabolite, pH, and turbidity monitoring. Experience in writing experimental protocols and summary reports, as well as presenting data for discussion. Proficient with computer programs such as Microsoft Excel, Word, PowerPoint. Experience in a GxP environment and working knowledge of the requirements of GMPs. Working knowledge of use of an electronic laboratory notebook (Benchling experience is a plus). Familiarity with DoE (Design of Experiments) and application of statistics. Strong interpersonal skills to collaborate well within the team and excellent written and verbal communication skills. Must be flexible with working hours as needed for the experiments. Polysaccharide team members require booster vaccination with PCV. Reports to: Director, Polysaccharide Pilot Plant Process Development &nbsp; Location: San Carlos, CA &nbsp; Expected Contract Length:&nbsp; 12months &nbsp; Hourly Range:&nbsp;$48.00 - $54.00 &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Engineer II (contract), Polysaccharide Pilot Plant Process Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Associate Director, Commercial MSAT for Polysaccharides will lead and facilitate launch readiness and commercial supply of the polysaccharides used in glycoconjugate vaccines. This role focuses on technical launch planning and execution by bringing best practices and coordinating cross-functional efforts for regulatory filings, facility readiness, and launch supplies. This role also provides leadership to ensure that the organization is equipped to effectively communicate the scientific and commercial rationale for critical raw material manufacturing processes to internal stakeholders, relevant CMOs, and to regulatory agencies. The incumbent will work with the organization to ensure on-time execution and appropriate planning for commercial lifecycle management. This position will be reporting to the Director, Commercial MSAT for Polysaccharides. The Associate Director will collaborate on overall program strategy, with primary responsibility and accountability for the polysaccharide drug substance intermediate.&nbsp; Manufacturing Science and Technology (MSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. As part of the Technical Operations organization, MSAT will lead the technical and process support for end-to-end commercial manufacturing, including Polysaccharides, Carrier Proteins, and Conjugation across all Drug Substances (DS). The range of activities will include technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle, etc.&nbsp; Essential Functions: DS Commercialization – Provide strategic and scientific leadership for polysaccharides with internal and external stakeholders and ensure successful execution of launch plans and post-launch commercial activities. Organization – Build a strong and highly-skilled team for the global network with special focus on polysaccharide manufacturing processes. Support resourcing recommendations on staffing requirements to meet organizational goals. Process robustness – Continuously improve process understanding and process robustness using staff and laboratory resources across the organization to monitor, trend, and optimize operations. Interface - Collaboration with cross-functional teams across the network, including Regulatory, CMC, Quality, Supply Chain, Procurement, and Process Engineering, to drive the successful development and commercial launch of carrier proteins for pipeline products. Tech-transfer new technologies - Ensure robust processes exist to support technical transfers and integration of new technologies. Support technical services - Support of our internal and external manufacturing network, including materials management and data analytics. Process validation and comparability - Provide leadership for the execution of process validation and process comparability activities. Effectively communicate the scientific and commercial rationale for polysaccharide processes to the Manufacturing organization for commercialization Regulatory - Engage In technical reviewing and authoring of regulatory filings and responding to questions received from health authorities. Effectively communicate the scientific and commercial rationale for polysaccharide processes to the Boards of Health for regulatory submissions for commercialization. Communicate - Effectively and efficiently communicate process performance to key stakeholders (internal-facing and external-facing). Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Leadership - Contribute as a member of the polysaccharide governance teams, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Travel - 10-30% travel required. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 9+ years of relevant experience for Ph.D., 11+ years for M.S./M.A., or 14+ years for B.S./B.A. Extensive experience in biologic production processes, including bacterial fermentation, recovery, and purification across multiple operational scales. Experience with polysaccharides and glycoconjugate vaccines highly preferred. Leadership experience in MSAT or Process Development in supervisory and/or matrixed team roles. Able to leverage deep technical knowledge in a collaborative manner to establish strategic plans and achieve collective goals. Excellent organization, problem solving and strategic planning skills. Highly skilled in both verbal and written communication with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges, and directs activities to implement effective solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Director, Commercial MSAT, Polysaccharides Location: San Carlos, CA or North Carolina Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $174,000 – $203,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Commercial MSAT, Polysaccharide

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The VP, US Trade &amp; Distribution will lead the channel, trade, and distribution strategy for Vaxcyte’s portfolio, initially focused on the commercial launch of Vaxcyte’s adult pneumococcal vaccine VAX-31. The emphasis will be on maximizing access and performance in retail pharmacy and Integrated Delivery Network (IDN) channels.&nbsp; The role will be instrumental in establishing Vaxcyte as a trusted supplier and oversee the creation of the U.S. distribution network optimizing for both the initial adult product launch and the subsequent pediatric product launch.&nbsp; This executive will set the vision, strategy, and drive operational execution to ensure day one launch readiness, channel partner management, regulatory compliance, and post-launch optimization. Essential Functions: Strategic Leadership Develop and own the enterprise-wide channel, trade, and distribution strategy for the initial adult vaccine launch, ensuring alignment with brand, market access, and supply chain priorities. Design integrated models that balance clinical needs, commercial access, supply chain efficiency, and gross-to-net cost considerations. Anticipate and respond to U.S. market and regulatory trends that impact retail and IDN distribution, preparing for future pediatric launches. Launch Planning &amp; Execution Oversee end-to-end planning and execution for the forward supply chain, including model selection, proposal development, negotiations, and partner review, selection and contracting. Lead all logistical operations to ensure readiness, including EDI, cold chain management, inventory placement, and order-to-cash systems, ensuring they are fully developed and functional. Ensure Day One launch readiness by meeting all regulatory requirements, securing product availability at targeted retail and IDN accounts, and implementing robust safety stock and contingency plans. Network and Account Management Establish and manage the pharmacy and distribution networks for Vaxcyte. Build, negotiate and manage the contractual agreements and strong working relationships with channel, trade, and distribution and pharmacy partners. Select, onboard, and oversee strategic partners, including RFP requirements and process management. Build and maintain effective relationships with distributors, retail chains and large IDNs to optimize distribution performance and patient access. Design, build negotiate and manage Trade Policies, Authorized Distribution Agreements (ADA), and Distribution Service Agreements (DSA). Manage all aspects of ongoing distribution account operations, including performance reviews, launch of new programs or service offerings, and comprehensive customer relationship oversight. Operational &amp; Regulatory Oversight Build the Trade Operations Team who will manage DSA performance, inventory levels, and Service Level fill rates, distribution data, and the underlying technology infrastructure. Establish systems and SOPs to ensure compliance with all relevant federal and state regulations (e.g., FDA, DSCSA, Anti-Kickback Statute), focusing on operational integrity and legal adherence. Implement data-driven processes to enhance supply chain transparency and enable informed operational decisions by leveraging both internal and external data sets (e.g., 852, 867, DDD). Monitor and manage launch operational KPIs such as inventory levels, fulfillment rates, customer experience, and distribution costs, with a focus on process optimization. Develop and oversee risk mitigation and inventory management strategies to maintain continuous product distribution regardless of disruptions. Drive ongoing process improvement by utilizing analytics and gathering feedback, with targeted attention on retail and IDN (Integrated Delivery Network) segments. Cross-Functional Collaboration Serve as the primary Trade representative on commercial and launch excellence teams, ensuring alignment and integration across functions. Support gross-to-net planning through deep channel economics expertise. Requirements:&nbsp; BA/BS degree in a scientific discipline, business, or marketing required.&nbsp; MBA or other advanced degree highly desired. Minimum of 15 years of industry related experience preferred with 7+ years of progressive experience in U.S. pharmaceutical or biotech trade, commercial operations, distribution, contracting, or market access, including leadership roles in product launches. Other combinations of education and/or experience may be considered. Demonstrated experience launching U.S. vaccines and/or specialty biologics (highly preferred). In-depth knowledge of the U.S. commercial and government healthcare and reimbursement environment, including: Distribution channels, Retail pharmacy channels, Integrated Delivery Networks (IDNs), Contract negotiation, Gross-to-net planning. Extensive regulatory expertise and experience with major commercial and government payer programs (State Medicaid, Medicare, VFC, Section 317). Experience and understanding of point-of-sale programs for retail pharmacy or equivalent environments. Ability to travel 20-40% of the time for various individual &amp; national customer meetings. Core Competencies Ability to create and execute strategic vision. Outstanding verbal, written, and interpersonal communication skills. Excellence in project management and driving operational rigor. Leadership of cross-functional teams with strong collaborative skills. Data-driven analytical decision-making. Thorough regulatory and compliance acumen. Skilled in contracting and negotiation with retail and IDN customers. Innovative approach to implementing digital and logistics solutions for retail/IDN account management. Capacity to rapidly assimilate information and prioritize/manage multiple initiatives. Proven ability to influence at executive level and work effectively across organizational boundaries. Reports to: Chief Commercial Officer &nbsp; Location: San Carlos, CA/Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $315,000 - $367,500&nbsp; &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Vice President, US Trade & Distribution

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Manager, Quality Assurance, Drug Product will play a critical role in ensuring the quality, safety, and compliance of commercial vaccine products. This leader will oversee QA activities related to manufacturing, batch disposition, deviations, and risk management, while actively participating in audits and continuous improvement initiatives. The ideal candidate brings extensive QA experience in the biotech or pharmaceutical industry, strong leadership skills, and the ability to partner effectively across functions to support a culture of quality. Essential Functions: Provide Quality Assurance oversight of Contract Manufacturing Organizations. Represent QA at internal cross functional team meetings and at Joint Project Team meetings. Lead batch disposition activities such as review of executed batch records, environmental monitoring and quality control data. Review and approve documentation such as master batch records, deviations, risk assessments, change controls, and CAPAs. Lead deviation and product complaint investigations Drive resolution of quality performance issues with the contract manufacturer. Support validation activities. Identify opportunities to streamline QA processes and systems Champion initiatives to enhance quality culture and operational excellence across the organization. Interact with key stakeholder to develop solutions to complex issues. Participate in compliance audits as required (health authority and contract manufacturer) Promote a quality mindset and quality excellence approach to all activities. Mentor and coach QA staff to strengthen technical capabilities and regulatory compliance mindset. Requirements:&nbsp; Bachelor’s degree in Chemistry, Biology, Pharmacy, Engineering, or a related field. Minimum of 8 years of experience in quality assurance, batch record review, manufacture, or quality systems management within the pharmaceutical, biotechnology, or life sciences industry. Other combinations of education and/or experience may be considered. Strong knowledge of cGMP, ICH guidelines, FDA/EMA regulations, and other international pharmaceutical quality standards. Knowledge and experience in Risk Management principles. Experience in both clinical and commercial parenteral drug product required. Strong Management and process improvement skills. Demonstrated experience managing batch record review, deviations and change management. Demonstrate experience in annual product reports Great organization skills and have an attention to details. In-depth understanding of aseptic manufacturing (biologics) operations. Ability to prioritize multiple assignments and changing priorities. Excellent problem-solving skills and the ability to manage complex investigations and root cause analyses. Strong written and verbal communication skills, with the ability to clearly present quality issues to cross-functional teams. Reports to: Director, Quality Assurance, Drug Product &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $166,000 – $193,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Assurance, Drug Product

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our analytical development team. The primary responsibilities for the successful candidate will include method development, sample testing, analyzing data, and authorizing protocols and reports. Essential Functions: Lead/assist in analytical method development of new assays. Perform analytical testing, data analysis and presentation in team meetings. Maintain thorough and accurate records of laboratory work. Support daily lab operations, sample inventory and sample shipment. Author analytical documents including but not limited to test method, protocols, and reports. Requirements:&nbsp; BS in Chemistry, Analytical Chemistry preferred, Organic chemistry, Biochemistry and Chemical biology considered, with 5+ years of relevant industry experience or MS with 3+ years. Other combinations of education and/or experience may be considered. Hands-on experience in chemical and biological assays such as colorimetric/ fluorometric microplate assays, HPLC, CE, UV-Vis, ELISA, qPCR and LC-MS. Understanding of basic principles of analytical method development/ validation/ qualification concepts. Attention to detail and excellent skills in record keeping/documentation. Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Effective communication and interpersonal skills, with the ability to collaborate cross-functionally and work effectively in a team environment. This position is a lab-based role and requires onsite presence. Reports to: Senior Scientist, Analytical Development, Raw Materials &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $118,000 – $138,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Associate Scientist, Analytical Development, Raw Materials

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a Sr. Manager for our Quality Control (QC) Reference Standards team to oversee the management and continuous supply of reference standards and critical reagents for testing and releasing clinical and commercial products. This role is pivotal in ensuring compliance with global regulatory guidelines and supporting our pipeline of high-fidelity vaccines. The Sr. Manager will work closely with internal teams (Process Development, Quality Assurance, Regulatory, Supply Chain, and Commercial) and external partners (CDMOs, CTLs, and CROs) to maintain the integrity of the reference standard program. Essential Functions: Reference Standards Management: Oversee the implementation and maintenance of the reference standards and critical reagent program, ensuring compliance with cGMP and ICH guidelines. Program Development: Support the development of global business practices, policies, and standards for reference standards and critical reagents, including qualification, requalification, and inventory management. Documentation and Compliance: Collaborate in the authoring and review of technical protocols, qualification reports, requalification reports, and Certificates of Analysis (CoAs) related to reference standards. Ensure timely updates to SOPs and other relevant documentation. Inventory Management: Manage supply chain logistics, including inventory and space planning, to ensure a continuous supply of qualified reference standards and critical reagents. Collaboration and Communication: Serve as a key point of contact within Vaxcyte QC and with external partners, fostering productive collaborations to support the company's vaccine programs. Technical Expertise: Provide technical guidance on assay qualification and validation to meet regulatory standards, and review test methods and release documentation for reference standards. Quality Oversight: Review and manage deviations, OOS/OOT results, and conduct risk assessments related to reference standards and critical reagents. Requirements:&nbsp; Bachelor’s, Master’s, or Ph.D. in Biochemistry, Chemistry, or a related field. Ph.D. with 5+ years of relevant QC experience, or MS with 7+ years of experience, or BS with 9+ years of experience, including significant experience in reference standard management. Other combinations of education and/or experience may be considered. Strong background in cGMP and ICH regulatory guidance associated with reference standards and critical reagents. Experience working with biochemistry, immunoassay, or microbiological assay techniques. Familiarity with statistical software (e.g., JMP) for data analysis, trending, and process optimization. Excellent organizational and project management skills, with the ability to handle multiple projects under tight timelines. Strong written and verbal communication skills, including the ability to work effectively in cross-functional teams. Proficiency in LIMS and other laboratory data management systems is preferred. Reports to: Senior Director, Global Analytical Sciences and Technology (ASAT) Lead &nbsp; Location:&nbsp;San Carlos, CA; Open to Remote &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $176,000 – $205,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Quality Control, Reference Standards

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Senior Manager for Drug Substance (DS) Commercialization has the responsibility for launch readiness and commercial supply of the conjugate drug substance. The conjugate product strategy will transition from the Process Development organization to Manufacturing Science and Technology (MSAT) during late-stage product development.&nbsp; This role focuses on technical launch planning and execution by bringing best-practices and coordinating cross-functional efforts for regulatory filings, facility readiness, and launch supplies. This role also provides leadership to ensure that the organization is equipped to effectively communicate the scientific and commercial rationale for conjugation process to internal stakeholders, relevant CMOs, and to regulatory agencies. The incumbent will be highly skilled in written communication, especially in regard to authoring Health Authority submissions (IND/BLA). The role will also require the ability to interact effectively with people of diverse backgrounds and perspectives. The incumbent will also work with the organization to ensure on-time execution and appropriate planning for commercial lifecycle management. This position will be reporting into the Director for Global DS Commercialization, Conjugation. The Sr. Manager will collaborate on overall program strategy, with primary responsibility and accountability for the drug substance strategy.&nbsp; Manufacturing Science and Technology (MSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. As part of the Commercial Manufacturing and Supply Chain organization, MSAT will lead the technical and process support for end-to-end commercial manufacturing, including Polysaccharides, Carrier Proteins, Conjugation across all Drug Substances (DS). The range of activities will include DS technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, and investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle etc.&nbsp; Essential Functions: DS Commercialization – Provide strategic and scientific leadership for polysaccharide to protein conjugation with internal and external stakeholders and ensure successful execution of launch plans and post-launch commercial activities. Organization – Build a strong and highly-skilled team for the global network with special focus on manufacturing processes. Support resourcing recommendations on staffing requirements to meet organizational goals. Process robustness – Continuously improve process understanding and process robustness by putting systems in place to monitor, trend, and optimize operations. Interface - Collaboration with cross-functional teams across the network, including Regulatory, CMC, Quality, Supply Chain, Procurement, and Process Engineering, to drive the successful development and commercial launch of the conjugate drug substance. Provides technical representation into initial technology transfer, product launch, product lifecycle, to the end of life/product retirement and for defining/developing the next generation of production technologies. Tech-transfer new technologies - Ensure robust processes exist to support technical transfers and integration of new technologies. Support technical services - Support of our internal and external manufacturing network, including materials management and data analytics. Process validation and comparability - Provide support for the execution of process validation and process comparability activities. Regulatory - Engage In technical reviewing and authoring of regulatory filings and responding to questions received from health authorities. Effectively communicate the scientific and commercial rationale for DS processes to the Boards of Health for regulatory submissions for commercialization. Communicate - Effectively and efficiently communicate process performance to key stakeholders (internal-facing and external-facing). Connect and build strong working relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively. Executing for Results - Set clear and challenging goals and take accountability for driving results. Comfortable with ambiguity and uncertainty; the ability to adapt nimbly and lead others through complex situations. Leadership - Contribute with the DS Commercialization lead and as member of the Global Manufacturing Operations, with an aim to ensure effective and efficient delivery of our life-enhancing therapies to our patients. Delegate effectively, celebrate diversity within the team, and manage team performance with a strong focus on colleague development. Travel - 10-30% travel required. Requirements:&nbsp; Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 5+ years of relevant experience for Ph.D., 8+ years for M.S./M.A., or 12+ years for B.S./B.A. Experience in development, tech transfer, scale-up or production of polysaccharide/protein conjugate vaccines Experience in MSAT or Process Development in supervisory and/or matrixed team roles. Able to leverage deep technical knowledge in a collaborative manner to achieve collective goals. Excellent organization, problem solving and strategic planning skills. Highly skilled in both verbal and written communication, especially in regards to authoring Health Authority submissions (IND/BLA) with the ability to interact effectively with people of diverse backgrounds and perspectives. Proactively recognizes needs and potential challenges, and independently identifies and implements effective steps and solutions. The ability to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy. An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry. Reports to: Director, Global MSAT Commercialization Lead, Conjugation &nbsp; Location: San Carlos, CA or North Carolina&nbsp; &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $165,000 – $193,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manager, Global Drug Substance Commercialization, Conjugation

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: The Director, Business Operations (Global QC) will lead the strategic design, implementation, and continuous optimization of global operational frameworks supporting Vaxcyte’s Quality Control (QC) and supporting Analytical interfaces. This role ensures that analytical inputs and QC operations are scalable, compliant, efficient, and aligned with corporate and regulatory expectations as the organization advances from development through commercial readiness. The Director will serve as the central business operations leader for the Global Quality Control, partnering with leaders in Analytical Development, Analytical Science &amp; Technology, Stability, Process Development, Manufacturing Science and Technology (MS&amp;T), and Quality. This individual will drive governance, process standardization, infrastructure development, and cross-functional coordination to enable timely, compliant, and uninterrupted supply of Vaxcyte’s innovative vaccines. Essential Functions: Operational Excellence &amp; Strategy• &nbsp; &nbsp;Lead the design and execution of operational strategies that translate Vaxcyte’s global vision into efficient, compliant, and scalable QC and analytical business operations.• &nbsp; &nbsp;Develop and maintain a global QC operations strategy, ensuring alignment with clinical and commercial objectives.• &nbsp; &nbsp;Implement continuous improvement frameworks (e.g., Plan-Do-Check-Act) to enhance efficiency, scalability, and compliance across analytical and QC processes.• &nbsp; &nbsp;Define and monitor key performance indicators (KPIs) that assess operational performance, quality, delivery timelines, and cost efficiency across the global analytics network.• &nbsp; &nbsp;Partner with cross-functional leaders to ensure analytical and QC infrastructure, systems, and processes are integrated into overall business objectives.• &nbsp; &nbsp;Lead initiatives that improve operational automation, data visibility, and process robustness. Governance &amp; Compliance• &nbsp; &nbsp;Establish and maintain robust governance frameworks for QC and analytical operations in alignment with global cGMP regulations and internal quality standards.• &nbsp; &nbsp;Define, visualize, and formalize QC business processes using RASCI principles, ensuring clear ownership and accountability across the analytical network.• &nbsp; &nbsp;Review and enhance the Quality Management System (QMS) infrastructure to close gaps, harmonize SOPs, and strengthen procedural consistency.• &nbsp; &nbsp;Ensure data integrity principles are embedded in all operational practices, compliant with Vaxcyte’s DI policies and global standards.• &nbsp; &nbsp;Support global inspection readiness and lead preparations for regulatory inspections, partner audits, and customer reviews.• &nbsp; &nbsp;Collaborate with Quality to ensure analytical operations and contract testing laboratories meet all compliance requirements. Infrastructure &amp; Systems Leadership• &nbsp; &nbsp;Oversee the development and validation of business systems, data management platforms, and documentation practices across global analytical and QC sites.• &nbsp; &nbsp;Ensure that contract and in-house laboratories maintain robust equipment qualification, calibration, and maintenance programs to support reliable analytical testing.• &nbsp; &nbsp;Lead network and site planning activities, including external partnerships and outsourcing strategies with CDMOs and CROs.• &nbsp; &nbsp;Develop business cases for laboratory expansion, outsourcing scenarios, and infrastructure investments to support strategic growth. Capability Building &amp; Team Leadership• &nbsp; &nbsp;Collaborate and mentor a global team of QC operations professionals to ensure scientific, technical, and operational excellence.• &nbsp; &nbsp;Drive training programs that enhance technical proficiency, compliance culture, and cross-functional understanding within the analytics organization.• &nbsp; &nbsp;Foster a culture of innovation, learning, and continuous improvement across the analytical network.• &nbsp; &nbsp;Collaborate closely with functional heads across Analytical Development, Analytical Science and Technology, Stability, and Manufacturing to harmonize operational practices.• &nbsp; &nbsp;Represent Global Analytics and QC Operations in governance bodies, steering committees, and cross-functional business forums. Requirements:&nbsp; • &nbsp; &nbsp;Bachelor’s or Master’s degree (or higher) in Biotechnology, Pharmaceutical Sciences, Engineering, or related field.• &nbsp; &nbsp;12+ years of progressive experience in Quality Control, Analytical Operations, or Technical Operations within a biotechnology or pharmaceutical company.• &nbsp; &nbsp;Demonstrated leadership in developing and managing operational systems in GMP-regulated environments.• &nbsp; &nbsp;Strong understanding of cGMP, global regulatory requirements, and analytical testing operations.• &nbsp; &nbsp;Proven ability to design and implement business processes, governance models, and performance management systems.• &nbsp; &nbsp;Experience with vendor management and collaboration with CDMOs/CROs on analytical testing and QC operations.• &nbsp; &nbsp;Exceptional communication, negotiation, and relationship-building skills with internal and external stakeholders.• &nbsp; &nbsp;Strong analytical, organizational, and problem-solving skills; adept at data-driven decision-making.• &nbsp; &nbsp;Demonstrated passion for process improvement, operational efficiency, and automation Reports to: Head of Quality Control &nbsp; Location: Visp, Switzerland Compensation:The compensation package will be competitive and includes an equity component. Relocation:&nbsp;This role is not eligible for relocation assistance.&nbsp; We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Business Operations (Global Quality Control)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an experienced and collaborative-minded Senior Director (or Director DOE) of Procurement to join our team.&nbsp; This individual will be responsible for owning and leading the enterprise Procurement function and procurement strategy, and for managing and scaling the team that focuses on indirect purchasing, policy, business process, and systems enablement.&nbsp; The key purchasing pillars of this Director’s scope of responsibility include enterprise-wide ownership of all non-inventory related sourcing and procurement activities, including clinical, sales &amp; marketing services, travel, and professional services with accountability for governance, compliance, and value creation across these categories. This individual will be responsible for helping the organization grow while balancing cost, risk, scalability, and speed of execution, and will serve as a key advisor to Finance and business leaders on sourcing trade-offs and procurement-related risk. We are looking for a savvy professional who is adept at strategizing, coordinating, and planning, and who can define and implement improvements in policies, processes, and procedures to enable the company’s growth. This individual will have a customer service mindset and partner closely with internal stakeholders to clarify business needs, strengthen vendor relationships, and source new suppliers capable of supporting a transition to a commercial-stage organization.&nbsp; A successful candidate will bring an enterprise mindset, the ability to design and implement right-sized tools and processes, and the flexibility to adapt to evolving business needs through pragmatic and innovative problem solving. &nbsp; This individual will manage a team of approximately 5–7 professionals and will be responsible for scaling the procurement organization over the next 2–3 years, including organizational design, talent development, performance management, and succession planning, to build a high-performing and sustainable function. &nbsp; Essential Functions: Own and govern procurement policies, procedures, and programs, and identify opportunities to enhance organizational value, efficiency, and compliance. Establish and oversee enterprise-wide procurement guidance, training, and escalation pathways for our business partners across all departments. Define and lead all strategic purchasing activities in support of research, lab operations and supplies, clinical, and other non-inventory categories, including professional services, outsourced providers, and contingent workforce planning. Establish consolidated supplier spend information and insights and create and manage operational performance metrics for procurement processes. Provide strategic oversight, guidance, and final approval for high-impact, high-risk, or complex negotiations to obtain optimal pricing and contract terms. Oversee and ensure best-in-class execution of sourcing (RFx) events across categories including, but not limited to, lab supplies, lab equipment, Facilities, IT, and MRO/CROs. Identify opportunities to consolidate vendors to achieve volume discounts, cost reduction opportunities and optimal terms. Collaborate with Technical Operations, Clinical, Commercial, IT, Legal and other key business functions to enable enterprise-wide supplier management. Ensure proper adherence to purchasing and contracting workflows. Work closely with accounting operations teams, FP&amp;A and accounts payable to resolve issues with purchase order and invoice discrepancies, ensuring proper internal controls and SOX compliance are in place. Evaluate, select, and implement procurement systems and tools, establishing a scalable roadmap for automation and integration with Finance and ERP systems. Work closely with FP&amp;A in developing or updating budgets and forecasts. Work closely with the company legal department to make sure contracts and terms are favorable. Ensure appropriate oversight of vendor setup, documentation, and diligence (e.g., W-8, W-9), delegating execution while maintaining accountability for compliance and a customer service orientation of the team. Coach, mentor and develop a high performing team. Other responsibilities as needs arise. Requirements:&nbsp; Bachelor’s Degree in Business Administration or related field is required. Minimum 14 years of progressive experience in procurement, strategic sourcing, or supply management within a biotech, life sciences, or pharmaceutical environment with owned laboratory facilities. Other combinations of education and/or experience may be considered. &nbsp; Demonstrated experience leading procurement organizations with significant indirect spend, complex vendor portfolios, and cross-functional stakeholders. ~10 of experience in a publicly traded company with strong appreciation for SOX controls, audit requirements and diligence in a public company setting ~7 years as a proven leader managing teams and supporting their development, training and goal achievement Demonstrated ability to identify and implement process improvements to purchasing workflows, P2P and S2P processes, including experience working effectively within cross-functional governance frameworks. Experience operating in ERP-enabled environments (e.g., NetSuite, SAP S/4HANA), with a strong understanding of procurement controls, system workflows, and audit implications Strong executive presence and the ability to influence and partner effectively with senior leaders Independent self-starter and a proactive individual with a drive to achieve goals and solve problems, sometimes without similar precedents. Ability to work in the HQ office 3-5 days a week Reports to: Sr. Vice President, Finance &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $257,000 - $300,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Director, Procurement

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte has an opportunity for a Senior Project Manager to manage complex, cross‑functional initiatives focused on IT, Finance, and Laboratory Systems implementations, ensuring smooth delivery across planning, requirements, system design, testing, deployment, training, and change management. This leader partners closely with finance teams, scientific/lab operations, IT, and vendors to deliver technology solutions that improve data integrity, operational efficiency, and strategic decision‑making.The ideal candidate brings substantial experience managing systems implementations, a deep understanding of financial and laboratory workflows, and the ability to drive clarity, alignment, and execution across diverse stakeholder groups. Essential Functions: Provide project management expertise in implementation of financial systems, lab informatics systems (LIMS, ELN, LES, instrument data platforms), and related IT business applications. Develop and maintain comprehensive project documentation including project charter, project plan, communication plan, risk management documentation, etc. Collaborate with cross‑functional stakeholders across Finance, IT, Lab Operations, Quality, Supply Chain, and external vendors. Drive all project phases: requirements gathering, solution design, configuration, integration, testing, validation, deployment, and hypercare. Facilitate regular project meetings, decision logs, documentation, and communication of updates to leadership and sponsors. Identify risks, constraints, and dependencies early; drive mitigation planning and contingency strategies. Lead change management strategies including communication plans, training, and post‑go‑live support. Leverage new systems to streamline workflows across finance and laboratory operations. Standardize processes, data models, and reporting across functions to strengthen operational efficiency and data reliability. Requirements:&nbsp; Bachelor’s degree in business, information technology, or a related field. Master’s degree preferred. Other combinations of education and/or experience may be considered. Minimum 8 years of project management experience in IT system implementations, including work with finance systems and lab informatics systems. Experience in biotechnology, pharmaceuticals, medical devices, or other regulated scientific environments. Experience with change management frameworks. Familiarity with GxP validation practices and documentation. Proven success leading multiple projects in complex, multi‑stakeholder organizations. Experience working with scientific, finance, and IT teams simultaneously. Strong understanding of financial processes (budgeting, GL, AP/AR, procurement, reporting) and laboratory workflows (sample lifecycle, instrument data, QA/QC, data integrity). Advanced proficiency in Smartsheet, including; Complex project plan development, Automation workflows, Portfolio and executive‑level dashboards Demonstrated ability to build dashboards and reporting tools that summarize health, risks, KPIs, and resource status for leadership. High level of organization, analytical thinking, resourcefulness, and problem‑solving. Ability to thrive in dynamic, high‑growth environments with evolving priorities. Excellent verbal and written communication skills, with the ability to engage and influence stakeholders at all levels. Reports to:&nbsp;Senior Director, Business Process Excellence &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $166,000 - $195,000 (SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Project Manager

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an accomplished Associate Director, Immunoassay Development to join the Global Analytical Development organization. This role will provide scientific and strategic leadership for immunoassay development across Vaxcyte's vaccine pipeline, supporting platform evaluation and innovation, outsourcing and vendor oversight, method transfer, validation, lifecycle management, routine analytical testing, and immunoassay control strategy.This is an onsite, laboratory-based scientific leadership role with significant hands-on responsibilities and daily engagement in laboratory operations, experimental planning, assay execution, study oversight, data review, and technical support. The Associate Director will lead and directly contribute to assay design, assay execution, data analysis, troubleshooting, method optimization, platform evaluation, method transfer support, validation readiness, and routine non-GMP or GMP-supporting analytical testing for complex conjugated vaccine programs and other vaccine pipeline assets.The successful candidate will bring strong technical expertise in immunoassay development for vaccines or biologics, with demonstrated experience developing, optimizing, troubleshooting, and lifecycle-supporting potency-, antigenicity-, identity-, and impurity-related immunoassays in CMC or regulated analytical environments. A key responsibility of this role will be to strengthen Vaxcyte's hands-on immunoassay capability by developing new fit-for-purpose immunoassays, supporting platform evaluation and innovation, advancing assay robustness, and contributing to analytical control strategy across the vaccine pipeline. The Associate Director will work closely with internal and external immunoassay subject matter experts, Analytical Development, ASAT, QC, Process Development, Manufacturing, Quality, Clinical Serology, Regulatory, Program Management, CROs, CDMOs, contract testing laboratories, and technology partners to support method development, outsourcing, validation readiness, routine testing, GMP readiness, and long-term assay lifecycle strategy. Essential Functions: Contribute to the establishment and growth of the Immunoassay Development Capability within the Global Analytical Development organization, with emphasis on hands-on immunoassay development, troubleshooting, method optimization, platform evaluation, routine testing, outsourcing support, validation readiness, and control strategy execution. Engage daily in laboratory operations, including experimental planning, assay execution, sample and reagent readiness, study scheduling, instrument and workflow coordination, data review, documentation, and hands-on technical support. Lead and directly execute laboratory studies for immunoassay development, optimization, troubleshooting, qualification support, method transfer, validation support, lifecycle management, and routine analytical testing. Provide hands-on technical leadership for immunoassays supporting potency, antigenicity, identity, impurity, characterization, comparability, release, and stability needs for complex conjugated vaccines and other vaccine pipeline programs. Design, execute, and interpret experiments to evaluate assay format, sample preparation, reagent strategy, plate or bead configuration, signal detection, curve behavior, recovery, precision, specificity, robustness, and system suitability. Independently troubleshoot immunoassay performance trends using structured, data-driven root-cause analysis approaches and clear experimental plans. Support development of new fit-for-purpose immunoassay methods from concept through optimization, qualification readiness, transfer readiness, validation readiness, and lifecycle strategy. Assess alternative and innovative immunoassay approaches, platforms, and formats to support assay modernization, multiplexing, throughput, sensitivity, specificity, robustness, and long-term control strategy. Support comparative evaluation of immunoassay technologies, including ELISA, MSD, Luminex, and other relevant ligand-binding assay formats. Perform and oversee routine analytical testing within the CoE, including development-stage testing, characterization testing, platform evaluation studies, method bridging, comparability support, reagent qualification, and other non-GMP or GMP-supporting analytical activities. Support outsourced immunoassay activities with CROs, CDMOs, contract testing laboratories, reagent vendors, and external technology partners, including technical scope definition, study design review, data review, vendor communication, and deliverable tracking. Support immunoassay method validation activities in partnership with ASAT, QC, Quality, Regulatory, and external testing partners, including protocol input, acceptance criteria, data interpretation, deviation support, and final report review. Partner with internal and external subject matter experts to understand assay design, critical reagents, reference materials, method performance attributes, and control strategy needs. Support QC and ASAT teams in technical questions related to release, stability, comparability, PPQ, method transfer, validation readiness, and commercial readiness activities. Contribute to immunoassay analytical control strategies, including critical reagent strategy, reference material strategy, sample preparation, assay controls, system suitability, bridging plans, trending, and lifecycle monitoring. Manage assigned immunoassay development, troubleshooting, outsourcing, validation-support, platform evaluation, and routine testing activities, including study planning, resource coordination, timeline management, data review, deliverable tracking, and risk escalation. Mentor and provide technical guidance to laboratory scientists on experimental design, assay execution, data interpretation, troubleshooting, documentation, and good laboratory practices. Contribute to regulatory submissions, health authority responses, technical reports, method development reports, validation strategies, comparability packages, platform evaluation summaries, and BLA-supporting documentation. Represent Immunoassay Development in technical project meetings, cross-functional reviews, vendor discussions, and external collaborations as needed. &nbsp; Requirements:&nbsp; PhD. in Biochemistry, Immunology, Analytical Chemistry, Biological Sciences, or a related discipline with a minimum of 7 years of relevant biopharmaceutical industry experience; or M.S. in a related discipline with a minimum of 10 years of relevant biopharmaceutical industry experience. Other combinations of education and/or experience may be considered. Significant hands-on laboratory experience developing, optimizing, troubleshooting, transferring, validating, lifecycle-supporting, and executing immunoassays in vaccine CMC, biologics analytical development, QC, ASAT, or other regulated analytical environments. Demonstrated expertise in immunoassay method development, including assay format selection, antibody reagent strategy, reagent screening, reagent evaluation and selection, sample preparation, assay optimization, robustness assessment, qualification, validation readiness, and lifecycle management. Strong technical experience with ligand-binding immunoassay platforms such as ELISA, MSD, Luminex, or other relevant immunoassay technologies. Proven ability to troubleshoot complex immunoassay performance trends using structured, data-driven root-cause analysis approaches. Experience evaluating alternative or innovative immunoassay platforms and translating experimental data into method development recommendations. Experience developing or improving potency, antigenicity, identity, or impurity assays supporting vaccine or biologics release, stability, comparability, process development, method transfer, validation, routine testing, or regulatory submissions. Experience supporting outsourced immunoassay activities, including CRO, CDMO, contract testing laboratory, reagent vendor, or external technology partner interactions. Demonstrated ability to support daily laboratory operations, including study planning, sample and reagent readiness, testing prioritization, data review, documentation, and technical troubleshooting. Direct experience with conjugated vaccines, polysaccharide-protein conjugates, multivalent vaccines, or other complex biologics is strongly preferred. Solid understanding of protein chemistry, polysaccharide chemistry, conjugation chemistry, antigen structure, antibody-antigen interactions, and biological sample matrix effects as applied to vaccine analytical development. Hands-on experience with MSD platforms is highly desirable. Hands-on experience with Luminex or other multiplex immunoassay platforms is a plus. Experience working in or supporting GMP-regulated analytical environments is desired, including familiarity with method qualification, validation, transfer, change control, deviations, investigations, CAPA, data integrity, and lifecycle management. Working knowledge of global regulatory expectations for analytical methods supporting vaccines and biologics, including FDA, EMA, ICH, and GMP expectations. Demonstrated ability to mentor, train, and provide technical guidance to laboratory scientists. Strong ability to manage multiple laboratory studies, technical workstreams, outsourced activities, validation-support activities, routine testing needs, timelines, and deliverables in a fast-paced, matrixed environment. Strong scientific judgment and the ability to make sound technical recommendations when working with incomplete, complex, or conflicting data. Excellent written and verbal communication skills, with the ability to clearly communicate technical concepts, study results, risks, and recommendations to cross-functional stakeholders and external partners. Strong commitment to data integrity, documentation quality, scientific excellence, accountability, and continuous improvement. Preferred Qualifications: Experience supporting late-stage development, PPQ readiness, BLA preparation, commercial launch, or lifecycle management of vaccine or biologics programs. Direct experience supporting analytical methods used for GMP release and stability testing. Experience with immunoassay transfer, validation, bridging, comparability, critical reagent qualification, reference material qualification, and long-term method performance monitoring. Experience managing or supporting outsourced immunoassay development, validation, platform evaluation, or routine testing activities with external laboratories or technology partners. Experience developing alternative or next-generation immunoassay methods to strengthen analytical capability and support long-term control strategy. Experience contributing to health authority responses or regulatory submissions on analytical, potency, antigenicity, or immunoassay-related topics. Experience helping build or scale analytical capabilities, Centers of Excellence, or laboratory teams within a growing organization. Experience with multivalent or highly complex vaccine programs. Experience with automation, high-throughput immunoassay workflows, multiplex assay design, LIMS, ELN, and digital data analysis tools. Reports to: Senior Director, Global Analytical Lead – Commercial Readiness and Analytical Strategy &nbsp; Location: San Carlos, CA &nbsp; Work Arrangement: Onsite &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $190,000 - $220,000&nbsp; &nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Director, Immunoassay Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Scientist II, Conjugation Development who will contribute to the development of a robust process for generating Vaxcyte’s proprietary pneumococcal conjugate vaccine. The successful candidate will be proficient in basic laboratory techniques and be responsible for the support of the scientists in the execution of large and complex experimentation. Specifically, this will include synthesis, purification, and analytical characterization of polysaccharide-protein conjugates. With the training provided, the successful candidate will be expected to optimize and troubleshoot the synthesis and purification procedures independently with minimal guidance. The candidate will work in a fast-paced environment, must be a collaborative team player, has a strong desire to learn new techniques and concepts, and be committed to Vaxcyte mission. Essential Functions: Make buffers and other process solutions to support the Conjugation team during Process Characterization Analyze conjugates with several methods including colorimetric assays and multiple HPLC assays. Purify conjugates using a variety of methods including size-exclusion chromatography and tangential flow filtration (TFF). Contribute to the development and execution of Design of Experiment (DoE) models for process development. Support the development work toward a process characterization of conjugate vaccine. Design and execute basic process development experiments with minimal guidance Complete any assigned tasks in high quality and in a timely manner. Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports. Assist in troubleshooting of instrumentation and test methods, including the ordering of supplies and maintenance of equipment. Participate in group meetings, present results of work, interpret data, and report results in an accurate manner. Work within a team environment and provide support to further team objectives. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Experience in setting up and carrying out chemical reactions. Experience with protein conjugation reactions is a major plus. Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, size-exclusion chromatography, and tangential flow filtration (TFF). Hands on experience with analytical methods including reversed-phase HPLC, colorimetric assays, size-exclusion chromatography (SEC), and SDS-PAGE for characterization of reaction products. Direct experience operating Agilent HPLC using OpenLab/ Chemstation software and/ or Waters UPLC and Empower software for data acquisition and analysis is a plus. Highly organized, strong attention to details and excellent record keeping/documentation abilities. Critical thinking and ability to analyze data. Eager and able to learn and understand new concepts. Strong interpersonal skills and ability to communicate effectively with team members. Ability to work under supervision and collaborate effectively with team members. Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work. Reports to: Scientist II, Conjugation Development Location: San Carlos, CA&nbsp;Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.&nbsp;Salary Range: $105,000 – $122,000 *(SF Bay Area). Salary ranges for non-California locations may vary. We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Scientist II, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: We are seeking a highly skilled Manager, Quality Systems to ensure adherence to regulatory standards, continuous improvement, and operational excellence within our organization. The ideal candidate will have experience in quality management systems (QMS), a background in regulatory requirements, and experience successfully validating, implementing and maintaining quality systems in a regulated industry. Essential Functions: Assist with development and maintenance of the company's Quality Management System (QMS) in accordance with company procedures and regulatory requirements (e.g.,.21CFR Part 11). Act as SME for the Vaxcyte QMS and assist users with technical system issues. Assist with driving continuous improvement initiatives that relate to QMS to enhance quality, efficiency, and compliance across all departments. Assist with GxP system implementation, validation, and maintenance activities from a QA perspective as required. Collaborate cross-functionally with IT, and other departments to ensure alignment on quality objectives and initiatives. Strive to foster a culture of quality and continuous improvement. Assist with preparation for and participate in regulatory inspections and customer audits, ensuring readiness and compliance. Ensure alignment with department management and company vision. Promote a quality mindset and quality excellence approach to all activities. Complete other responsibilities, as appropriate. Requirements:&nbsp; Bachelor's degree in a relevant scientific discipline. Minimum of 5 years of experience in quality management within a regulated industry (e.g., medical devices, pharmaceuticals, biotechnology). Other combinations of education and/or experience may be considered. Demonstrate knowledge of GXP regulations and guidelines as it pertains to Quality Systems. Experience in assisting with the validation, implementation, and managing Quality Management Systems (QMS) compliant with FDA regulations (e.g., 21 CFR Part 820), and other relevant regulatory requirements. Experience driving cross-functional collaboration. Excellent analytical and problem-solving abilities, with a keen attention to detail. Experience with Veeva QMS required. Knowledge or experience with Computer System Validation and/or Computer Software Assurance highly desirable. Experience with test script execution, a plus. Ability to work in a collaborative team environment. Reports to: Associate Director, Quality Systems &nbsp; Location: Hybrid; San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $148,000 - $173,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Manager, Quality Systems

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented Associate Engineer II, Conjugation Development who will contribute to the development of a robust process for generating Vaxcyte’s proprietary pneumococcal conjugate vaccine. The successful candidate will be proficient in basic laboratory techniques and be responsible for the support of the team in the execution of large and complex experimentation. The candidate will work in a fast-paced environment, must be a collaborative team player, has a strong desire to learn new techniques and concepts, and be committed to Vaxcyte mission. Essential Functions: Prepare samples for analysis, execute analytical procedures according to the SOP, and perform data analysis. Provide assay supports to Conjugation Development team. Contribute to CMO Manufacturing oversight via document review. Present/communicate data to the Conjugation Development team. Operate, maintain, and troubleshoot HPLC instruments. Analyse data using appropriate software tools. Interpret, communicate, and present data. Assist with authoring and maintaining standard operating procedures. Document results of analyses and experiments with an electronic notebook system. Requirements:&nbsp; BS degree in Chemical Engineering, Biological Engineering, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Prior hands-on experience in a laboratory setting. Hands on experience with analytical methods including Colorimetric Assays, HPLC-SEC, SEC-MALS, and SDS-PAGE is desired. Experience with purification methods such as Dialysis, HPLC, or Tangential Flow Filtration (TFF) is a plus. Highly organized, strong attention to details and excellent record keeping/documentation abilities. Critical thinking and ability to analyse data. Eager and able to learn and understand new concepts with ease. Strong interpersonal skills and ability to communicate effectively with team members. Ability to work under supervision and collaborate effectively with team members. Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work Reports to: Staff Engineer, Conjugation Development Location: San Carlos, CA&nbsp;Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.&nbsp;Salary Range: $105,000 – $122,000 *(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Associate Engineer II, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an Associate Scientist II, Conjugation Development, who will contribute to the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on the synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The successful candidate will apply a strong foundation in analytical chemistry and laboratory techniques to optimize and troubleshoot processes, while also supporting related areas such as analytical development and stability studies. This position requires strong organizational skills, clear communication, and the ability to work in a fast-paced, cross-functional environment. Essential Functions: Perform and optimize multi-step syntheses of protein-polysaccharide conjugates. Purify polysaccharides and conjugates using methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF). Analyze polysaccharides and conjugates using methods such as colorimetric assays, HPLC assays, SEC-MALS, and SDS-PAGE, and contribute to method bridging studies and qualification to ensure robustness and consistency. Maintain accurate, well-organized experimental records and support data verification and analysis to enable process optimization and reproducibility. Assist with troubleshooting of synthesis, purification, and analytical procedures. Track inventory of critical reagents and assist with ordering as needed. Support maintenance of assigned lab instruments, perform general lab duties, and contribute to training new team members. Present experimental results and progress updates at group meetings. Contribute to laboratory protocols, reports, and other documentation supporting process development. Collaborate effectively with team members and contribute to cross-functional activities. Requirements:&nbsp; BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience. Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, and size-exclusion chromatography; experience with TFF is desirable. Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE. Hands-on experience with protein conjugation reactions or chemical modification of polysaccharides is desirable. Strong attention to detail, organizational skills, and record-keeping abilities. Effective communication skills, both verbal and written. Ability to work both independently and collaboratively in a fast-paced environment. Enthusiasm for learning new skills and applying them to challenges outside of current expertise. Commitment to integrity, professionalism, and safety in all aspects of work. Reports to: Senior Scientist, Conjugation Development Location: San Carlos, CA&nbsp;Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.&nbsp;Salary Range: $105,000 – $122,000 *(SF Bay Area). Salary ranges for non-California locations may vary. &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is looking for an energetic and talented individual to join our analytical development team. Primary responsibility for the incumbent will include method development, sample testing and data analysis, protocol and report authorization, and analytical method transfer oversight and coordination. Essential Functions: Independently perform method development for a wide range of analytical techniques used in raw material testing for both quality control and characterization, supporting pre-clinical and clinical projects. Support method transfer to external contract testing labs; design and perform studies to assist troubleshooting of QC testing, method qualification/validation or issues related to the methods as needed. Perform analytical testing, data analysis and interpretation and present in various project and functional team meetings. Collaborate with cross-functional teams to achieve project timelines and goals. Maintain thorough and accurate records of laboratory work. Author analytical documents including but not limited to test method, protocols, and reports. Requirements:&nbsp; PhD in Analytical Chemistry, Biochemistry or a related field with 2-5 years of industry experience; MS with 7+ years of industry experience; BS with 10+ years of industry experience in Pharma/Biotech. Other combinations of education and/or experience may be considered. Extensive hands-on experience in a wide range of analytical techniques, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, LC-MS, GC-MS, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, PCR, etc. Adeptness in learning: given the broad range of molecular structures and analytical methods involved, the ability to quickly learn and adapt to new techniques and technologies is paramount. Ability to analyze complex problems, identify potential solutions, and make informed decisions is critical for the success of this role. Familiar with regulatory standards and quality systems (e.g., GLP, GMP) Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Effective communication and interpersonal skills, with the ability to collaborate cross-functionally and work effectively in a team environment. This position is a lab-based role and requires onsite presence. Reports to: Associate Director, Analytical Development, Raw Materials &nbsp; Location: San Carlos, CA &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $146,000 – $171,000 (SF Bay Area). Salary ranges for non-California locations may vary.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Scientist II, Analytical Development for Raw Materials

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte is seeking an accomplished Director, Immunoassay Development to establish and lead a dedicated analytical function focused on immunoassay development for complex conjugated vaccines. This role will build and manage a laboratory-based team responsible for developing, sustaining, and continuously improving potency- and antigenicity-based immunoassays to support CMC development from preclinical through BLA-stage programs and commercialization. A key initial focus of this role will be stewardship of the VAX-31 MSD immunoassay platform, which has been developed and advanced to Phase 3 through extensive internal leadership spanning clinical serology, GLP studies, and immunoassay development. The successful candidate will work in close partnership with current immunoassay leadership to ensure comprehensive knowledge transfer, continuity of scientific and execution excellence, and the long-term robustness of the immunoassay strategy as accountability and responsibility intentionally transition into Analytical Development. This is a hands-on scientific leadership role anchored in CMC execution, GMP readiness, and lifecycle management of immunoassays supporting vaccine development, lot release and stability testing and commercialization. Essential Functions: Establish and lead a new Immunoassay Development function within Analytical Development, defining scope, strategy, and operating model aligned with CMC and program needs. For VAX-31, partner closely with current immunoassay leadership to learn and internalize the full development history, scientific rationale, and performance characteristics of the existing MSD-based immunoassay platform. Serve as scientific steward for the VAX-31 immunoassay, providing troubleshooting, root-cause analysis, and technical problem-solving support to Quality Control (QC) and Analytical Sciences and Technology (ASAT) teams. Support ASAT activities for VAX-31, including qualification, lifecycle management, and change control of critical immunoassay reagents. Develop and execute immunoassay strategies to support potency, antigenicity, identity, and trace-level impurity testing for conjugated vaccines across the pipeline. Lead the development and optimization of antigenicity- and potency-based immunoassays suitable for late-stage development and commercial use. Drive continuous improvement of existing immunoassays to enhance robustness, QC-friendliness, throughput, and long-term performance, even when methods are already deemed adequate. Build, mentor, and manage a team of laboratory scientists, fostering a cohesive, innovative, nimble, and high-performing team culture grounded in scientific rigor and accountability. Provide critical scientific judgment and problem-solving leadership when addressing complex, ambiguous, or conflicting technical challenges across programs. Manage immunoassay development activities across multiple projects, prioritizing resources, timelines, and deliverables in a fast-paced, matrixed environment; proactively escalate risks and issues to line management and project team as appropriate. Partner cross-functionally with Process Development, Manufacturing, Quality, Clinical Serology, and Regulatory teams to ensure alignment with overall CMC strategy and program timelines. Ensure immunoassay methods meet FDA, EMA, and ICH expectations for vaccines and biologics. Support regulatory submissions and health authority interactions through technical input, data review, and authorship of CMC documentation. Champion data integrity, scientific excellence, and continuous learning within the immunoassay organization. Requirements:&nbsp; Ph.D. in Biochemistry, Immunology, Analytical Chemistry, Biological Sciences, or a related field (or equivalent experience) with a minimum of 10 years of experience. Other combinations of education and/or experience may be considered. Significant hands-on experience developing immunoassays within vaccine CMC, analytical development, or other regulated laboratory environments. Expert-level, hands-on experience with MSD (Meso Scale Discovery) or closely related immunoassay platforms, including method development, optimization, troubleshooting, and lifecycle support. Direct experience with conjugated vaccines, including polysaccharide–protein conjugates. Solid understanding of protein chemistry and conjugation chemistry, particularly as applied to biological drug and vaccine development. Demonstrated expertise in potency and antigenicity assays supporting vaccine release, stability, and comparability. Strong working knowledge of GMP and global regulatory expectations (FDA, EMA, ICH) for analytical methods supporting vaccines. Demonstrated ability to think critically and exercise sound scientific judgment when navigating complex, ambiguous, or conflicting technical and organizational challenges. Proven track record of scientific problem-solving, including data-driven decision-making and root-cause analysis. Strong written and verbal communication skills, with the ability to clearly and efficiently communicate technical concepts across interdisciplinary and cross-functional teams. Ability to operate effectively in a fast-paced, matrixed environment, manage multiple priorities, and meet aggressive timelines. Project and resource management experience, including planning and coordination of materials, staffing, timelines, and deliverables, with the ability to appropriately escalate issues and risks. Preferred Qualifications: Experience supporting late-stage development and/or commercial vaccine programs. Direct interaction with global health authorities on analytical, potency, or immunoassay-related topics. Experience building or scaling analytical capabilities within a growing organization. Background in multivalent or highly complex vaccine programs. Reports to: Vice President, Analytical Development &nbsp; Location: San Carlos, CA (Onsite, laboratory-based leadership role) &nbsp; Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. &nbsp; Salary Range: $213,000 – $250,000 *(SF Bay Area). Salary ranges for non-California locations may vary.&nbsp; &nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Director, Immunoassay Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests. &nbsp; As a CMC IT Intern for Vaxcyte, you will work on a project as outlined below:&nbsp; Map manufacturing data from source documents into standardized structures within Vaxcyte’s internal data platform. Extract and organize data from spreadsheets and batch records to map tests, units, and procedures, and update the proprietary platform. Verify configurations to ensure data matches source records.&nbsp; The Intern will learn and practice:&nbsp;&nbsp; How data impacts vaccine development and manufacturing workflows within the biotech industry Common data management challenges, including data consistency, standardization, and downstream usability. Foundational skills in structure problem solving and collaboration with cross-functional teams.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.&nbsp;&nbsp; Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) or Graduate Degree with a focus on Computer Science, Data Science, or related field.&nbsp; Proficiency in Microsoft Office. &nbsp; Strong attention to detail and work quality. Demonstrates collaboration and teamwork.&nbsp; &nbsp; Enthusiastic-Shows curiosity and is eager to learn. Dedicated.&nbsp; Reports to:&nbsp;Senior Systems Analyst &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, CMC Information Technology, VAXDATA

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests. &nbsp; As a Conjugation Development Intern for Vaxcyte, you will work on a project as outlined below:&nbsp; Assist with experimental studies to understand how process inputs influence conjugation workflows and downstream processing. Generate and organize analytical data for predefined quality attributes and contribute to summary slides or short write-ups of results and learnings. Provide general lab and project support to the team by preparing materials, maintaining documentation, and helping execute planned experiments on schedule. The Intern will learn and practice:&nbsp;&nbsp; Conjugation techniques that enable protein-polysaccharide vaccine development. Application of Design of Experiments in a CMC/process development setting. How to interpret analytical results and use data-driven decision making to evaluate process impacts. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.&nbsp;&nbsp; Requirements:&nbsp; Currently pursuing a BS or MS degree in Bioengineering, Chemical Engineering, Chemistry, Biochemistry, or a related discipline; enrolled student with at least 2 years of university coursework completed. Prior wet-lab experience strongly preferred, including accurate pipetting, solution preparation, and basic documentation practices. Enthusiastic and curious to learn about bioconjugate development. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Reports to:&nbsp;Scientist I, Conjugation Development &nbsp; Location: San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Conjugation Development

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As an Immunoassay Intern for Vaxcyte, you will work on a project as outlined below: Optimize the current assay platform to improve sensitivity and accuracy for detecting pneumococcal antigens in human samples. Conduct experiments to test the assay's ability to detect antigens in human samples spiked with known concentrations. Analyze and interpret results to refine assay protocols and troubleshoot issues that arise during testing.&nbsp; The Intern will learn and practice: Hands-on experience in optimizing immunoassays, which are widely applicable to various immunoassays used in clinical and manufacturing settings. Design experiments to test assay performance, analyze results, and troubleshoot issues.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Biology, Biochemistry, or related field.&nbsp; Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to: Senior Manager, Nonclinical &amp; Immunoassay &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Immunoassay

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Legal Intern for Vaxcyte, you will work on a project as outlined below: Review and better leverage existing Legal/enterprise tools; enhance the weekly Legal Dashboard and contribute to a broader Legal Team Dashboard, including automation, usability, and AI features. Support PowerPoint slide automation and content generation, and assist with Ironclad API development and integrations. Evaluate AI tools for recording, summarizing, and documenting Legal trainings, and explore best practices for using Microsoft Copilot across email and documents. Develop an internal AI-focused newsletter with tips, best practices, and resources. Research and recommend relevant AI conferences, panels, and external programming for Legal teams. The Intern will learn and practice: Gain hands-on experience owning and executing AI initiatives within an in-house legal team. Develop practical skills in AI implementation, tool evaluation, automation, and technical-to-business communication, while learning how legal teams responsibly pilot and adopt AI solutions in a regulated corporate environment. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) or a Master’s Degree with a focus on Computer Science, Data Science, Artificial Intelligence, Machine Learning, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to:&nbsp;Senior Vice President, General Counsel, Chief Compliance Officer and Corporate Secretary &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Legal Technology & AI

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Polysaccharide Intern for Vaxcyte, you will work on a project as outlined below: Conduct a literature review to evaluate potential methods (chemical treatment) for removing residual impurities from intermediate fill materials. Design and execute laboratory studies to assess the effectiveness of the selected purification approach across multiple PCV serotypes. Perform chemical treatments and measure polysaccharide recovery using relevant analytical assays. Document experimental conditions and results, analyze data, and evaluate potential impacts on critical quality attributes (CQAs). Present findings and recommendations to support ongoing PCV process development efforts. The Intern will learn and practice: Applying scientific literature to inform experimental design and guide purification process development strategies. Evaluating purification concepts to determine feasibility and relevance for real-world manufacturing applications. Assessing method performance through structured feasibility studies and comparative analysis. Developing data-driven decision-making skills to support process optimization and technical recommendations. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 2 years at university completed) or Master’s Degree with a focus on Bioengineering, Chemical Engineering, Chemistry, or Biochemistry. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Nice to Have – previous lab experience (wearing PPE, handling reagents, buffer making, pipetting) and equipment experience (AKTA) Reports to:&nbsp;Engineer I, Polysaccharide &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Polysaccharide

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Protein Intern for Vaxcyte, you will work on a project as outlined below: Perform a literature review to understand cell-free protein synthesis (CFPS) and key principles of small-scale bioreactor operation. Support the design and execution of development studies aimed at establishing operating conditions in the Ambr 15 microbioreactor system for maintaining CFPS reaction setpoints (e.g., temperature, dissolved oxygen, and pH). Analyze experimental data to help design next studies or finalize operating conditions for 10 mL CFPS reactions. Document findings by drafting a work practice/SOP for running CFPS reactions in the Ambr 15 system. Present results and recommendations to the Protein team to support ongoing process development efforts. The Intern will learn and practice: Bioreactor operations and scale-down principles. Data analysis (process trends and analytical results). Electronic lab notebook (ELN) record keeping. Science communication. SOP/work practice writing skills.&nbsp; Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Biochemical Engineering, Chemical Engineering, Bioengineering, or Biochemistry. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to:&nbsp;Scientist I, Protein &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Protein

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Research Intern for Vaxcyte, you will work on a project as outlined below: Focus on protein expression and purification to support development of alternate protein carriers. Contribute to technical and analytical efforts to finalize processes. Screen protein constructs and purification strategies using small-scale expression and purification experiments. Generate and analyze data to identify promising constructs and optimize purification workflows. The Intern will learn and practice: Different AKTA FPLC chromatography methods, such as IMAC, SEC, and AEX, while obtaining meaningful exposure to industry relevant workflows. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Master’s Degree with a focus on Microbiology, Molecular Biology, Biochemistry, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Reports to:&nbsp;Scientist I, Research &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Summer Intern, Research

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a Research Intern for Vaxcyte, you will work on a project as outlined below: Support formulation and stability activities for a pipeline molecule within Research, gaining hands-on laboratory experience. Assist in executing a stability study, including sample preparation, storage, and testing. Collect, organize, and analyze stability data to evaluate storage and handling conditions. Assess the impact of excipients on molecule stability and overall formulation performance. Present findings and recommendations to the Research team. The Intern will learn and practice: The day-to-day responsibilities of a bench scientist within a pharmaceutical research environment. Fundamental principles of vaccine development, including how Vaxcyte’s programs contribute to global public health. Designing and executing high-quality experiments using the scientific method in an industry setting. Collecting, analyzing, and interpreting experimental data to support research decisions. Operating and gaining hands-on experience with modern laboratory instrumentation and analytical tools. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Chemistry, Biology, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to:&nbsp;Senior Associate Scientist, Research &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.&nbsp; &nbsp; WHAT&nbsp;we do is every bit as important as&nbsp;HOW&nbsp;we do it!&nbsp;Our work together is guided by four enduring core values: &nbsp; *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. &nbsp; *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. &nbsp; *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. &nbsp; *MODEL EXCELLENCE:&nbsp; The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.Summary: Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.&nbsp; As a CMC IT Intern for Vaxcyte, you will work on a project as outlined below: Support development and customization of an nf-core pipeline for protein structure prediction. Assist with deployment and optimization of the pipeline in Azure within an existing VNet. Develop or enhancing a basic user interface to allow scientists to submit jobs and review results. Act as a liaison between scientists and IT to gather requirements and translate them into technical solutions. The Intern will learn and practice: How protein folding prediction tools and prediction tools are operationalized in an enterprise setting. Deploy and secure scientific applications in Azure within a virtual network. Skills in performance optimization, cost analysis, and cloud resource tuning. Collaboration with scientists and IT professionals to translate research needs into scalable technical solutions. Program Details: The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location. Requirements:&nbsp; Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) with a focus on Computer Science, Bioinformatics, Computational Biology, or related field. Proficiency in Microsoft Office. Strong attention to detail and work quality. Demonstrates collaboration and teamwork. Enthusiastic-Shows curiosity and is eager to learn. Dedicated. Reports to: Principal Data Systems Engineer &nbsp; Location:&nbsp;San Carlos, CA &nbsp; Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.&nbsp;We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. &nbsp;

Senior Manufacturing Systems Analyst

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