Prime Medicine is a biotechnology company focused on developing innovative RNA-based therapeutics to treat genetic diseases. The company's cutting-edge research and technology aim to revolutionize the field of medicine by providing personalized treatments for patients with rare and common genetic disorders. With a dedicated team of scientists and experts, Prime Medicine is committed to advancing the future of healthcare through its groundbreaking approach to gene therapy.

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Prime Medicine is seeking a Contract GMP Associate / Technician to support GMP operations across our facility. This hands-on role will involve execution of procedures in compliance with internal standards and regulatory guidelines. The successful candidate will work collaboratively to ensure operational readiness, instrument care, and routine support of GMP activities. Responsibilities Prepare materials and solutions according to established procedures and documentation. Support daily activities related to instrument/equipment operation, maintenance, and troubleshooting. Follow standard operating procedures and maintain compliance with internal quality standards. Document work in accordance with data integrity and GMP expectations. Support facility workflows, workspace upkeep, and readiness of equipment and spaces Qualifications: Associate’s or Bachelor’s degree in a chemistry, biochemistry, or related field, or equivalent experience. Minimum of 1-2 years of experience in a GMP or other regulated environment. Demonstrated ability to follow written procedures and maintain detailed records. Strong organizational, communication, and collaboration skills. Mechanical aptitude and experience assembling/disassembling GMP equipment and instruments. Familiarity with standard lab, chemistry, and bioprocess equipment and workflows. &nbsp;Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Contractor, GMP Technician

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: The Lab Technician plays a vital role in supporting the daily operations of our chemistry laboratory, ensuring a clean, safe, and well-stocked working environment for scientific staff and operations. This position is responsible for inventory management, lab organization, safety compliance, and general operational support. The ideal candidate is detail-oriented, proactive, and comfortable working in a fast-paced scientific environment.&nbsp; Key Responsibilities: Follow established Quality SOPs to track, receive, and organize inventory, including reagents, lab consumables and PPE in LIMS and CMS. Manage and monitor laboratory equipment by coordinating service/repairs as needed and ensuring documentation is to Quality standards. Update and maintain instrument records in a qualified asset management system. Assist with internal transport and movement of 55-gallon solvent barrels via the use of a Powered Industrial Truck (keg lifter). Ensure compliance with safety policies, including proper storage and disposal of chemicals, biohazards, and sharps. Assist with lab documentation including SOPs, safety records, and equipment logs.&nbsp; Coordinate with vendors, service providers, and building facilities as needed. Participate in audits, safety inspections, and emergency preparedness drills. Qualifications: 2+ years of experience in a laboratory or lab operations role preferred. Strong organizational skills and attention to detail. Ability to work independently and manage multiple priorities. Familiarity with common lab equipment and safety practices. Excellent communication and interpersonal skills. Proficiency with basic software tools (e.g., Microsoft Office, inventory management systems). Nice to Have:&nbsp; Experience in a regulated environment (e.g., GLP, GMP, etc.). Knowledge of EHS protocols. Familiarity with LIMS or lab tracking software. Experience with high volume solvent systems. Working Conditions:&nbsp; This position requires on-site presence in a laboratory setting. Will involve lifting of boxes, carboys or lab supplies (up to 50 lbs). Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Contractor, Lab Operations Technician

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Prime Medicine is seeking a Contractor, Patient Advocacy and Medical Affairs Specialist to build strong relationships with patient communities and lead strategic collaborations with patient advocacy organizations across all therapeutic programs. Reporting to the Vice President of Clinical Science, this role will also work closely with the Clinical Development team to support additional medical affairs initiatives, including conference and publication planning, Key Opinion Leader (KOL) coordination, and clinical study support as it relates to patient engagement. The ideal candidate may be remote but should be able to be on site for key events and be willing to travel ~15% of the time, including conferences and patient advocacy meetings.&nbsp; Responsibilities Support and help execute Prime Medicine’s patient advocacy strategy and our ‘Patients First’ philosophy. Identify, build and maintain strong relationships with patient advocacy communities, particularly in rare disease communities, and support sponsorship opportunities. Ensure the patient experience is heard within Prime to help shape clinical and regulatory development planning Build educational materials for patient communities around genetic medicines and understand where needs or opportunities may exist for support Coordinate, plan, and manage budgets for patient advocacy events and speakers. Collaborate cross-functionally with Clinical Development, Corporate Communications and Legal teams as needed, ensuring compliance around interactions with stakeholders Assist with KOL coordination, and conference/publication and external presentation planning activities as needed. Qualifications: Minimum B.S or B.A. candidate for Biology, Health Sciences, Business, Marketing, or similar field. Minimum 2 years experience in patient engagement or organizational strategy with advocacy groups in a biotech or pharma setting. Rare disease experience strongly preferred. Familiarity with medical affairs and scientific communication planning, including KOL engagement and conference/publication planning activities preferred. Strong interpersonal, oral, and written communication skills; ability to quickly build rapport with diverse stakeholders. &nbsp;&nbsp;Ability to build trust and rapport with patients, families and caregivers through exceptional listening skills. Understanding of compliance requirements for patient advocacy and familiarity with the drug development process; genetic therapy experience a plus Excellent organizational and collaboration skills and ability to manage multiple projects in a matrixed environment, including event planning. Ability to travel occasionally to patient advocacy events or conferences. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Contractor, Patient Advocacy and Medical Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Join our collaborative, agile and fast-paced Liver Programs &amp; Development Sciences team to develop Prime Editors that could help patients in rare diseases and beyond. Reporting to the Vice President, Liver Programs &amp; Development Sciences, the successful candidate will be responsible for leading the strategic oversight of all safety (GLP and non-GLP) and tolerability studies in rodents, NHP and other appropriate animal models, to be conducted either internally and/or at external contract research laboratories within the US and internationally. The ideal candidate must exhibit exceptional functional expertise, collaborative behavior and be comfortable to excel in cross-functional matrixed project team environments, deliver results in a timely manner and have excellent communication skills to effectively communicate to managers, project teams and leaders in the organization. The ideal candidate will be onsite 5 days a week in Cambridge, MA.&nbsp; Responsibilities Toxicology strategy and sub-team leadership Develop and own the global toxicology strategy for portfolio programs from discovery through IND/NDA submissions Provide expert analysis on nonclinical safety findings, offering actionable guidance to cross-functional teams (Discovery, DMPK, Clinical, Pharmacovigilance) Study Design, Execution &amp; Oversight Lead the design and oversight of GLP and non-GLP toxicology studies, including general, genetic, germline transmission, reproductive, carcinogenicity, safety pharmacology, and toxicokinetics Manage CRO relationships from selection to monitoring to ensure scientific rigor, timelines, budgets, and regulatory compliance Cross-functional Influence &amp; External Collaboration Act as subject-matter expert across project teams, guiding risk assessment strategy and decision-making Collaborate with pharmacology and research team to select predictive models and explore mechanisms of toxicity in the process of lead optimization and development candidate selection Lead IND-enabling studies and effort to establish NOAEL and TI. Collaborate with Clinical to support the translation from nonclinical to clinical testing. Collaborate with TDO to support the establishment of safe and well characterized products, bridge nonclinical and clinical materials, evaluate excipient and novel component safety and manage risk from process impurities Regulatory Submissions &amp; Documentation Collaborate with Regulatory by authoring and reviewing nonclinical sections of regulatory submissions: INDs, CTAs, IBs, BLAs, NDAs, NDAs/MAAs, and responses to health authority inquiries Collaborate and support Research, Clinical and TDO in respective sections in regulatory document where safety and toxicity are tightly connected among studies conducted in different line functions Serve as company’s nonclinical toxicology representative in meetings with regulators (FDA, EMA, ICH) Qualifications: PhD in Toxicology, Pharmacology, or related field (DABT certification preferred) 10-12+ years of industry experience in pharmaceutical/biotech toxicology Expert knowledge of toxicology disciplines: general, developmental/reproductive, safety pharmacology, carcinogenicity, toxicokinetics Demonstrated track record managing GLP studies, CRO relationships, and regulatory submissions across lifecycle stages Excellent scientific writing skills for regulatory and clinical documents; strong oral communication for both internal and external engagements Deep familiarity with GLP regulations, FDA/EMA/ICH guidelines, and health authority interactions Proven ability to lead cross-functional teams under tight timelines in a dynamic biotech or pharma environment. Strong interpersonal and organizational skills, with a high degree of attention to detail. Ability to deal with competing priorities, strong reasoning, detail oriented and creative problem-solving ability is essential “Do-what-it-takes” approach to problem solving and prospective thinking. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view. Independently motivated, detail oriented and good problem-solving ability. Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities. Positive, outgoing and collaborative attitude with a passion for helping patients using innovative science Be ready to embrace the principles of the Prime culture Preferred Experience Experience in genomic medicine (gene transfer and/or gene editing) drug development History of published work and presentations at scientific conferences Experience evaluating assets for in-licensing or business development due diligence Experience with in silico or translational toxicity screening models. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Director of Safety Assessment

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: Prime Medicine is seeking a patent agent to join our highly skilled legal group. This position will report directly to our Senior Director of Intellectual Property. In this role you will work in a fast-paced, collaborative environment on a broad range of intellectual property matters in the emerging field of gene editing therapeutics. You will work directly with company scientists and the other members of the legal team to help to build, develop, and maintain a strong IP portfolio, protecting Prime Medicine’s technology platform and pipeline. Responsibilities: Conduct scientific and technical research and provide support to the IP and legal group. Work directly with Prime’s scientists to understand new technological developments and inventions and collaborate with company patent attorneys on patent filings. Conduct patent and scientific literature searches, and analyze patents and scientific technical documents to assist patent attorneys in patent prosecution, counseling, and litigation. Draft and prosecute domestic and foreign patent applications under supervision of company patent attorneys. Qualifications: At least one year of experience as a practicing patent agent in the life sciences field. PhD in Molecular Biology, Genetics, Biochemistry, or a related discipline required. Registered to practice before the U.S. Patent and Trademark Office (USPTO). Strong preference for candidates with experience in gene editing and CRISPR technologies. Excellent academic credentials with strong oral and written communication skills. Excellent organizational skills and attention to detail. Proficient in Microsoft Office (Word, Outlook, and Excel). Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Patent Agent

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Join and a collaborative, agile and transformative Clinical Development Operations (CDO) team by leading and contributing to transformative clinical programs for patients in rare diseases and beyond.&nbsp; Reporting to the Director of Clinical Operations, the successful candidate will be responsible for the operational execution of clinical trials within our liver directed gene therapy portfolio and will effectively lead the study start-up, implementation, and management of our studies, ensuring adherence to timelines, budget, and quality standards in support of regulatory filings. The ideal candidate must be comfortable overseeing and managing cross-functional study teams, including internal stakeholders and external vendors.&nbsp; The ideal candidate will be able to be onsite 1-2x/week in our Watertown office.&nbsp; Responsibilities You will oversee the day-to-day operations of study execution, with a focus on site oversight from study startup to study closeout, patient enrollment, monitoring, compliance, and data flow and metrics from the clinical sites, CROs and vendors. Lead a dynamic cross-functional team to ensure study deliverables are met on time and within budget guidelines, while ensuring quality in accordance with the protocol and ICH GCP guidelines. Initiate and manage study-level timelines; drive study startup activities, including site feasibility and selection, regulatory submissions, and site activation. Participate in the development and review and provide clinical operations input into key clinical documents such as the protocol, investigator brochure, CRFs, regulatory documents, clinical study reports and other documents and plans as appropriate. Develop critical study documents including informed consent forms, study conduct documents such as study manuals, the Study Operations Manual, study tools, etc. Train team members and site staff, including vendors, as needed Support the identification and onboarding of new vendors, including contract and budget negotiations. Manage invoice and budget tracking for individual studies and provide input into budget forecasting activities. Perform and document study level sponsor oversight of outsourced clinical activities, including oversight to ensure that safety concerns and/or adverse events are identified and appropriate responses to such concerns are developed and executed. Partner with clinical supply chain to help manage study level clinical supply demand Ensure reliable quality data are delivered by reviewing monitoring reports, protocol deviations, clinical data listings and performing or overseeing site monitoring visits, as needed. Develop action plans to address protocol compliance, safety, data and administrative issues with clinical sites and CROs. Develop and maintain strong, collaborative relationships with key stakeholders within and external to Prime Medicine. Participate in clinical operations workstreams and SOP development for critical department initiatives. Assist with the onboarding and mentoring of new or junior clinical operations associates; support oversight and management of consultants. Qualifications: BS/BA/RN Degree in science or a health-related field is preferred Minimum 7 years relevant industry clinical development experience, with 2+ years of independent trial management preferred. Sponsor experience is strongly preferred. Experience and understanding of drug development and global clinical trial operations Pivotal clinical trial oversight, or closely relevant experience required, and gene therapy experience preferred. Experience with all aspects of trial and site startup, CRO, vendor and laboratory management Familiarity with clinical data review and data management processes, including Data Monitoring Committees Must be able to travel up to 25%, domestically and internationally Creative problem-solver with excellent verbal and written communication skills Strong interpersonal and organizational skills, with a high degree of attention to detail. Ability to deal with competing priorities, strong reasoning, detail oriented and creative problem-solving ability is essential Ability to lead a cross-functional team, with the potential to lead multiple projects; be willing to work with tight timelines and to multi-task in a fast-paced environment with changing priorities with a sense of urgency Excellent knowledge of GCP, ICH and FDA regulations; working knowledge of international regulations in the EU preferred “Do-what-it-takes” approach to problem solving and prospective thinking. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view. Independently motivated, detail oriented and good problem-solving ability. Excellent organizational skills, sufficient to multi-task in an extremely fast-paced environment with changing priorities. Positive, outgoing and collaborative attitude with a passion for helping patients using innovative science Be ready to embrace the principles of the Prime culture Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Clinical Trial Manager

Fall 2025 Co-op: Medical Writing & Clinical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking a Scientist to join our cystic fibrosis team to lead&nbsp;the&nbsp;assessments of&nbsp;in vitro and in vivo delivery&nbsp;to&nbsp;lung epithelial cells. This role will&nbsp;utilize&nbsp;primary 2D and 3D mammalian cell cultures&nbsp;and mouse&nbsp;tissues&nbsp;to evaluate AAV- and LNP-mediated delivery to target cells. This work will&nbsp;guide the&nbsp;selection&nbsp;of lead candidate components&nbsp;for both AAV and LNP&nbsp;drug candidates.&nbsp;We are looking for curious problem solvers who enjoy working on fast-paced, exciting projects, working within a&nbsp;team,&nbsp;and are passionate about developing&nbsp;gene&nbsp;editing technologies to&nbsp;improve&nbsp;human health.&nbsp; The ideal candidate will be on&nbsp;site 5 days a week in Cambridge, MA.&nbsp; Primary Responsibilities: Utilize 2D and 3D epithelial&nbsp;cell&nbsp;cultures to assess delivery&nbsp;and potency&nbsp;of AAV- and LNP-based discovery candidates. Differentiating and maintaining multiple primary epithelial cell cultures. Preparing/dissociating cells and tissues into single cell suspensions to perform cell-based analyses using flow cytometry and molecular biology techniques.&nbsp; Collaborate cross-functionally with internal teams on study design, execution, data collection, data analysis, and interpretation.&nbsp; Present data in written reports and oral presentations. Qualifications: PhD in&nbsp;cell biology, immunology,&nbsp;genetics,&nbsp;developmental biology,&nbsp;or related field with&nbsp;0-2+ years of relevant experience (or BS+8, MS+6).&nbsp; Experience with complex non-immune primary mammalian cell cultures, including cell differentiation and use of transwells. Experience dissociating tissues for downstream cell-based assays. Familiarity/experience with molecular biology techniques (e.g., qPCR, DNA sequencing, western blot) Strong organizational and critical thinking skills, attention to detail, and ability to work both independently and as part of a collaborative team. &nbsp; Excellent communication and interpersonal skills to thrive in a cross-functional setting. &nbsp; Preferred Qualifications: Subject matter&nbsp;expertise&nbsp;in lung biology, drug development for lung diseases, and considerations for in vivo delivery of test articles to the lung. Hands-on experience with in vivo lung delivery (intratracheal and nebulization). Hands-on experience with flow cytometry panel design, sample preparation, instrument operation, and data analysis. Experience with cell sorting. Development of cell-based immunogenicity assessments such as intracellular cytokine staining and ELISPOT.&nbsp; The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$120,000&mdash;$147,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Scientist I, Cell-Based Assays

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a diligent, motivated, and enthusiastic co-op for the Spring 2026 cycle who has experience and interest in analytical technologies including HPLC, LC-MS, and capillary electrophoresis (CE) to join the analytical development (AD) team. The successful candidate will be able to participate in the development of separation-based analytical methods for the Prime Editor delivery platform and work cross-functionally to advance the Prime pipeline. There will be opportunities to participate in other cross-functional projects that are crucial to the success of in vivo and ex vivo gene editing therapeutic drug development. Primary Responsibilities: Participate in separation-based method (HPLC, LC-MS, CE) development to assess lipid nanoparticle (LNP) drug products and their components. Assist senior-level scientists with buffer preparation, maintenance of instruments, and developing up-to-date analytical methods that help to increase in-process analytics capacity. Maintain detailed and accurate records of experimental data, protocols, and conclusions in an electronic notebook meeting the cGMP requirement Data analysis, interpretation, and presentation within the team. Qualifications: Currently enrolled in a B.S. or M.S. program in biochemistry, chemistry, chemical engineering, pharmaceutical science, or a related field. Basic knowledge of separation sciences and technologies. Ability to handle multiple projects in a fast-paced environment. Excellent troubleshooting and communication skills. Ability to work independently and within a team. Skilled in documenting findings and activities in comprehensive reports and ensuring proper inventory of materials and analytical equipment. Preferred Qualifications: Hands-on experience with LC-MS, CE, and/or cell culture is preferred. Previous co-op experience in the biotechnology industry. Independently motivated, detail-oriented, and excellent problem-solving abilities. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Analytical Development, LNP Drug Product

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 cycle to join the analytical development (AD) team. The candidate will gain valuable hands-on experience with laboratory techniques such as HPLC, collaborate cross-functionally with process development and quality control teams, and assist in the development of novel separation-based methods to solve complex analytical challenges and advance the pipeline. There will be also many valuable opportunities to learn about the scientific and regulatory requirements of in vivo and ex vivo gene editing therapeutic drug development and participate in projects that are crucial to the success of Prime Medicine. Primary Responsibilities: Perform a variety of assays to support companywide analytical needs for the analysis of drug substance components such as mRNA and guide RNA, and drug products such as LNP Under guidance, execute method development with separation-based methods to characterize drug substance and drug product Document experimental data meeting analytical development requirements in electronic notebooks and present findings at team meetings Effectively communicate with team members and other groups including process development, quality control, and laboratory operations Qualifications: B.S. or M.S. candidate in biochemistry, chemistry, chemical engineering, or a related field Basic knowledge of separation sciences and technologies, with an understanding of the fundamental principles behind biological and chemical techniques Ability to work independently and collaboratively as needed Excellent organization, documentation, and communication skills, with the aptitude to handle multiple projects in a fast-paced environment Skilled in writing comprehensive reports of laboratory activities and ensuring proper inventory of consumables, reagents, and analytical equipment Independently motivated and detail-oriented, with the ability to identify and solve technical issues Preferred Qualifications: Hands-on experience with separation-based analytical techniques such as liquid chromatography or electrophoresis Experience working in process development, analytical development, and/or quality control groups Experience working in a GxP environment Understanding of gene therapy within the biotechnology industry What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Analytical Development, mRNA Drug Substance

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a Spring 2026 co-op with a background in cell and molecular biology to join our Immunology team. This role provides a unique opportunity to work hands-on in a collaborative, fast-paced environment contributing to screening and validation of Prime Editing strategies across our immune-related indications. As a part of this role, you will gain valuable technical skills in cell and molecular biology while developing a deep understanding of immune cell biology, gene editing technology, and CAR-T cell therapy applications. The position will involve work on human immune cells, contributing to innovative research with potential therapeutic applications. We are looking for curious problem-solvers who thrive in a collaborative team environment and are passionate about advancing gene editing technologies for the treatment of human diseases. Primary Responsibilities: Cell Culture &amp; Functional Assays Perform primary human cell culture using aseptic technique Conduct program-specific cell-based functional assays, including flow cytometry Process in vivo samples for downstream analysis Molecular Biology &amp; Gene Editing Extract genomic DNA, perform digital PCR (dPCR), and prepare samples for next-generation DNA sequencing Assist in Prime Editing experiments and downstream molecular analysis Data Analysis &amp; Collaboration: Design and plan experiments with scientific rigor Analyze and interpret data, contributing to team discussions Document results in an ELN, and present findings in team meetings Qualifications: B.S. candidate in Cell &amp; Molecular Biology or a related major Basic understanding of cell and molecular biology Strong teamwork and communication skills Scientific curiosity, attention to detail, and excellent record-keeping skills Passionate about human disease research and motivated to help patients Preferred Qualifications: Hands-on experience with aseptic technique and cell culture Experience with basic molecular biology techniques (e.g., DNA extraction, PCR) Familiarity with flow cytometry or other immune-based assays What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: CAR-T Immunology

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in Biology and/or Health-related sciences to join the Clinical Development team. The Prime Medicine clinical development team is a tight knit, closely collaborative, highly creative group working to make the promise of Prime Editing a reality for patients with severe genetic diseases.&nbsp; The qualified candidate will be highly motivated, organized and collegial.&nbsp; The candidate will be involved in the process of operationalizing clinical trials of gene therapy for patients with genetic diseases. Primary Responsibilities: Learning from and assisting the operations team in managing clinical trials Participate in internal and external cross-functional study meetings; assist with meeting preparation, scheduling, and meeting minute taking and review Communicate with study sites to assist with patient visit scheduling, ensuring necessary study materials are delivered on time, patient sample tracking, and ensuring data entry is on-track for study deliverables Assist with maintaining study files, updating study materials (patient brochures, Informed Consent Forms, study manuals), and tracking of study deliverables and activities Qualifications: B.S or B.A. candidate for Biology or a Health sciences field, or similar Excellent analytical and written and oral communication skills Ability to work independently and as part of a team Comfort with basic statistical concepts What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Clinical Trials Operations

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester to work in a cross-functional LNP formulation and process development team. The candidate will work with formulation scientists, process development engineers, and chemical engineers to optimize mRNA and LNP formulation and processes related to the manufacture of LNPs. The candidate will gain hands-on experience with various LNP formulation techniques and processes, analytical and biophysical characterization, and play a critical role in solving challenging problems associated with LNP formulation and process development.&nbsp;&nbsp;&nbsp;&nbsp; We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being. Primary Responsibilities: Collaborate with the LNP formulation and process development team, and cross-functional teams to execute experiments supporting Prime Medicine goals Execute experiments to optimize and understand the robustness of LNP formulations and related processes Perform analytical testing for assessing LNP formulations and payload quality as it relates to critical process parameters Effectively communicate results to internal and external meetings, and present the final summary to the team Document and manage all experimental planning and progress in electronic lab notebook in an organized manner, providing statistical analysis and troubleshooting where appropriate. Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies. Qualifications: B.S./M.S. candidate in Chemical Engineering, Chemistry, Bioengineering or Biochemistry Prior wet lab experience with processes and methods of making and testing LNPs is preferred. Prior Co-Op experience(s) is preferred. Knowledge of mixing techniques, tangential flow filtration, and characterization techniques (DLS, plate based assays, HPLC) for LNPs Familiarity with DOE is a plus Excellent written and verbal communication skills. Curious, ability to work independently or collaboratively as needed Self-motivated, detail-oriented with strong critical thinking skills and excel at identifying and solving problems. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: LNP Process Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in Biology, Health-related sciences or Medical Writing to join the Clinical Development team. The Prime Medicine clinical development team is a tight-knit, collaborative, highly creative group working to make the promise of Prime Editing a reality for patients with severe genetic diseases.&nbsp; The qualified candidate will be highly motivated, articulate, analytical and collegial.&nbsp; The candidate will be involved in the development of critical clinical documents for gene therapy trials, such as clinical study protocols and Investigator Brochures and provide support to clinical trial design and development strategies.&nbsp;&nbsp; Primary Responsibilities: Support critical writing activities and content creation under the Director of Medical Writing, working cross-functionally to develop and produce high-quality deliverables such as clinical study protocols, Investigator Brochures, study reports, and IND/CTA documents In partnership with the team, critically analyze and interpret non-clinical and clinical data (internal and external) to develop content, conclusions and messaging. As needed, perform literature and scientific database searches in support of analyses and development of background summaries.&nbsp; Assist with developing formats, templates, processes and standards, style guides, workflow and operating procedures. Perform document QC and document formatting as requested; support medical writing SOP development and infrastructure build. As needed, support the various clinical functions (clinical operations, clinical science) for ongoing clinical trial execution. Qualifications: M.S, B.S or B.A. candidate for Biology, Statistics or a Health sciences field, or similar Excellent analytical and written and oral communication skills; demonstrated technical writing capabilities and desire to learn more Strong skills with various document software solutions and cloud programs for document creation (e.g., Microsoft Word, Office, Adobe, Sharepoint etc.) as well as familiarity with AI writing support programs and data visualization (e.g., Spotfire, etc.). Attention to detail and thoroughness related to processes, consistency, grammar, syntax, and scientific accuracy Ability to work, communicate transparently and collaborate with colleagues and external stakeholders as a team-player in a dynamic environment Preferred Qualifications: Course work in medical sciences, and/or familiarity with medical terminology and writing Basic understanding of cellular and molecular biology underlying gene therapy What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Medical Writing & Clinical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in biological or chemical techniques to join the Analytical Development and QC team. The candidate will learn cutting-edge technology in the field of gene and cell therapy, obtain hands-on experience with a broad range of analytical techniques, gain understanding in the scientific and regulatory requirements for phase appropriate analytical testing, and play a key role in solving complex technical challenges related to our prime editing strategy. This is a unique position with the opportunity to contribute directly to the advancement of prime editing programs toward the clinic. We want curious problem solvers who enjoy working on exciting projects, working within a team, and are passionate about developing genetic editing technologies to better human health and well-being. Primary Responsibilities: Support product development sample analyses, in-process, release and stability testing for: LNP-based drug products Prime editing component RNAs Participate in stability and reference standard programs, including protocol/report preparation, data compilation, and trend analysis, etc. Assist with sample management Conduct clean room lab environmental monitoring for GMP manufacturing suites Document and communicate experimental data in electronic notebooks per cGMP requirements Collaborate with teammates across the organization and program teams to support the product and method development, method qualification. Contribute to laboratory functionality, safety, and QC process optimization Flexibility to support taking on new projects and troubleshooting as needs arise and priorities are dynamic&nbsp; Identify opportunities for assay optimization, process improvements, and automation Qualifications: Currently enrolled in B.S./M.S. program in Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, Chemistry, Chemical Engineering, pharmacology, or a related field Completion of foundational biology, biochemistry, microbiology, or chemistry coursework with a laboratory component Ability to work both independently and collaboratively Flexibility in taking on new projects and troubleshooting as needs arise Self-motivated, detail-oriented with strong attention to problem-solving ability, and organizational skills Excellent verbal and written communication skills Eagerness to learn GLP/GMP practices and new analytical techniques Comfortable engaging in cross-functional teamwork and communication Ability to handle multiple projects in a fast-paced environment. Preferred Qualifications: Understanding of fundamental principles behind biological, microbiology, or chemical techniques, such as UV-vis, HPLC, UPLC, LC-MS, PCR/qPCR/ddPCR, potency assay, CFU identification and counting, etc. Hand-on experience with biological or chemical analytical techniques, such as sample extraction, preparation, dilution, and analysis are preferred Knowledge and/or experience in the field of gene and cell therapy, or willingness to learn Previous intern or co-op experience in biotechnology industry What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Quality Control

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a Co-op student for the Spring 2026 semester with a strong background in chemistry or biochemistry to join our guide RNA chemistry team. The selected candidate will contribute to the synthesis, purification, and analysis of oligonucleotides. This position provides hands-on experience with nucleic acid techniques, oligonucleotide characterization, data documentation, and opportunities to present findings in team meetings. We welcome curious, collaborative problem solvers who are passionate about advancing gene-editing technologies to improve human health. Key Responsibilities: Perform solid-phase synthesis of oligonucleotides using automated DNA/RNA synthesizers such as the Mermade12. Support purification and analysis of oligonucleotides with HPLC, UPLC, and LCMS. Prepare buffers and manage inventories of chemicals, reagents, and consumables. Assist with maintenance and troubleshooting of laboratory equipment, including synthesizers, speedvacs, lyophilizers, and HPLC systems. Maintain accurate electronic laboratory notebooks (ELNs), analyze and present data, and uphold safe laboratory practices. Coordinate with scientists to maintain an oligonucleotide inventory for the final released guide RNA Qualifications: Current B.S. candidate in Chemistry, Biochemistry, or a related field; basic knowledge of organic chemistry preferred. Prior experience working in a chemistry or biochemistry laboratory. Strong organizational skills with the ability to prioritize and meet deadlines in a fast-paced environment. Proficiency with common computer applications (Excel, Word, PowerPoint). Excellent troubleshooting and communication skills. Ability to work independently as well as collaboratively in a team. Preferred Qualifications: Exposure to nucleic acid chemistry through coursework or laboratory experience. Familiarity with analytical techniques such as HPLC, UPLC, or LCMS gained through academic labs or internships. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Small-Scale Guide RNA Chemistry

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking a Scientist/Senior Scientist with expertise in lipid nanoparticle (LNP) formulation and application of LNPs to mouse models to join our LNP Discovery team focused on developing non-viral delivery systems for cystic fibrosis therapies. This role involves designing and characterizing LNPs for in vivo delivery of Prime Editor RNA molecules, with hands-on in vivo work in pulmonary delivery studies. This role offers a unique opportunity to contribute across the full spectrum of LNP development, from formulation to in vivo delivery, within a collaborative, interdisciplinary cross-functional program team. We are looking for curious problem solvers who enjoy working on fast-paced, exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.&nbsp; The ideal candidate will be onsite 5 days a week in Cambridge, MA.&nbsp; Primary Responsibilities: Design and formulate LNPs using microfluidics; characterize using DLS, zeta potential, pKa, and Ribogreen assays. Execute and support&nbsp;in vivo studies focused on pulmonary delivery of LNP formulations including intratracheal delivery in preclinical models. Collaborate with internal teams on study design, execution, data collection, and interpretation. Support downstream analyses using flow cytometry and molecular biology techniques. Collaborate cross-functionally to integrate in vivo findings into delivery platform development. Present data in written reports and oral presentations. Qualifications: PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 0-2 years of relevant experience (or BS+8, MS+6). Experience with lipid nanoparticle (LNP) formulation, QC, and characterization techniques Hands-on experience with mouse handling, dosing, and tissue collection; intratracheal delivery (e.g., broncoscope) strongly preferred. Familiarity/experience with molecular biology techniques (e.g., qPCR, DNA sequencing, mammalian cel culture, and flow cytometry preferred. Strong organizational and critical thinking skills, attention to detail, and ability to work both independently and as part of a collaborative team. Excellent communication and interpersonal skills to thrive in a cross-functional setting. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Scientist/Senior Scientist, LNP Discovery

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 cycle with knowledge in cell and molecular biology to join the Immunobiology team. The qualified candidate will work hands-on with a highly collaborative, fast-paced project team to support Prime Editor selection by understanding the associated immunobiology. In this position, you will learn cell and molecular biology skills and develop a deep understanding of gene editing and immunology. Primary Responsibilities: Processing tissues into single cell suspensions for use immunobiology assays Aseptic culture of primary and immortalized mouse and human cells Setting up, performing, and collecting and analyzing data for in vivo, ex vivo, and in vitro immunogenicity assays Preparing cell samples for flow cytometry assays Data analysis, interpretation, and presentations within the team Qualifications: B.S. candidate in Cell &amp; Molecular Biology or related discipline Basic knowledge of molecular biology, cell biology and biochemistry Excellent troubleshooting and communication skills Ability to work independently and within a team Preferred Qualifications: Hands-on experience with aseptic cell culture of mammalian cells Experience with tissue dissociation Experience with flow cytometry Familiarity with Excel and PowerPoint for data analysis Independently motivated, detail-oriented, and excellent problem-solving abilities What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Immunobiology Assay Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in cellular-based studies to join the Lung Biology team. The candidate will be involved in supporting critical efforts in developing prime editing therapies for Cystic Fibrosis patients. This role will focus on supporting preclinical and in vitro studies with an emphasis on flow cytometry, tissue processing, and advanced cell culture systems such as air–liquid interface (ALI) cultures. The successful candidate will thrive in a fast-paced research program and will enjoy working with colleagues within and across teams from multi-disciplinary backgrounds. Primary Responsibilities: Keen interest in learning and performing the downstream analysis of in vivo studies, including tissue sample preparation, in vitro assays (PCR and Next-gen sequencing) and data analysis Set up air–liquid cultures of human bronchial epithelial cells and maintain them throughout the experimental period Plan and execute in vitro assays to evaluate gene editing activity in relevant primary cell models Follow protocols, standard operating procedures, execute assigned tasks and maintain ELN. Share responsibility in lab reagent inventory and maintaining equipment. Work and collaborate cross-functionally with colleagues. Collect, analyze and present data in team meetings. Qualifications: Bachelors/Masters candidate in Biology-related major Direct experience performing routine wet lab procedures and experiments Hands on experience with sterile techniques and culturing of mammalian cell culture including primary cells Experience with tissue sample preparation and immunostaining assays (flow cytometry, FACS, ICC/IHC) is a plus Preferred Qualifications: Flow cytometry/FACS experience, including sample preparation and data analysis In vitro molecular assays such as PCR/RT-qPCR Gene editing technologies and viral and/or non-viral delivery What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: Lung Biology

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview Prime Medicine is seeking a Quality Assurance (QA) Director to serve as the company’s primary quality assurance expert across both clinical and nonclinical programs. This role will partner strategically with Clinical Development and Nonclinical functions to establish and maintain pragmatic, risk-based quality frameworks that ensure regulatory compliance and data integrity from early development through clinical execution. The ideal candidate brings hands-on QA experience in gene therapy modalities and a track record of sound judgment, collaborative decision making, and effective partnership with cross functional teams.&nbsp; The ideal candidate will be onsite 2-3 days a week in Watertown, MA.&nbsp; Quality Strategy &amp; Governance&nbsp; Define and implement the clinical and nonclinical quality strategy for Prime Medicine, embedding ICH E6(R3) and ICH M3(R2)/OECD principles from first-in-human through pivotal stages.&nbsp;&nbsp; Establish and maintain systems and processes (including SOP development) to improve the quality and compliance of both clinical and nonclinical studies, providing oversight and support to CRO GLP studies and internal non-GLP study activities in both the United States and Rest of World (ROW).&nbsp; &nbsp; Partner tightly with Nonclinical, Clinical Operations, CMC, and Regulatory teams to make risk‑balanced, time‑bound decisions that protect subjects and program timelines.&nbsp; Maintain and advance the phase‑appropriate Quality Management System (QMS) for GCP, applying proportionality to indication, phase, and patient risk. Provide input to and perform reviews of Deviation, CAPA, and Change Management records.&nbsp; Ensure data capture, management and analysis is fit for purpose, including audit trail reviews and software assurance approaches to satisfy 21 CFR Part 11/EU Annex 11 compliance requirements.&nbsp; &nbsp; Support or lead QA audits and inspections of clinical and nonclinical sites, vendors and studies, ensuring appropriate follow-up and CAPA closure. Contribute to the authoring, review, and revision of SOPs, templates, and procedural documents related to GLP and GCP activities.&nbsp; Nonclinical Study Oversight&nbsp; Ensure nonclinical study protocols are reviewed and approved on time, and that deviations from approved protocols are properly documented, evaluated, and reported. Implement systems and workflows to ensure that data in study reports are accurate, complete, and traceable through the ELN to raw data and animal subjects where applicable. Confirm that bioanalytical method qualification and validation studies are conducted in accordance with internal SOPs, ICH M10, and other applicable regulatory guidance. Review bioanalytical method reports for clarity, traceability, and data integrity from source data through final report. Serve as the quality assurance liaison to CROs conducting GLP studies, providing compliance oversight to ensure adherence to 21 CFR Part 58 and OECD GLP requirements.&nbsp; Clinical Study Oversight&nbsp; Lead implementation of ICH E6(R3) principles by integrating quality-by-design and Critical-to-Quality (CtQ) factors into study planning, execution, and monitoring. Conduct proportionate risk assessments and maintain defined Quality Tolerance Limits (QTLs) as appropriate to ensure participant safety and data reliability. Partner with CMC teams as needed to ensure ATMP GMP standards are maintained in accordance with the trial protocol, pharmacy manual(s) and related documents;&nbsp; use manufacturing quality knowledge (e.g., process validation) to support comparability assessments for clinical impact. Review critical study documents (e.g. clinical protocols, ICFs, monitoring plans, and other essential documents) to ensure compliance with applicable regulations, SOPs, and GCP guidelines.&nbsp;&nbsp;&nbsp; Ensure the maintenance of all QA documentation in the QMS and TMF, if&nbsp; applicable. Apply a risk-based oversight model that tailors monitoring, deviation management, and data governance to identified risks; ensure timely risk review, communication, and documentation of key quality issues and remedial actions.&nbsp; &nbsp; Partner with study teams on vendor selection/qualification; conduct audits, maintain the audit schedule, establish Quality Agreements and provide ongoing oversight of vendor performance. Provide coaching and just-in-time training to study teams and sites on product-specific GCP expectations. &nbsp; Receive, investigate, and escalate reports of potential scientific misconduct or serious breaches, ensuring appropriate root‑cause analysis, documentation, and regulatory reporting. Lead inspection readiness efforts as required.&nbsp; Chair/participate in mock inspections and interview training; storyboard key risks/issues and dossier positions; lead remediation sprints on identified gaps. &nbsp; Required Qualifications&nbsp; 10+ years in GCP/Clinical Quality Assurance, including 5+ years in cell &amp; gene therapy; direct experience in gene editing modalities strongly preferred. Demonstrated success as a primary or sole QA lead supporting early-phase clinical and nonclinical programs. Deep, current knowledge of ICH E6 (R3), ICH M10, OECD GLP, and FDA/EMA expectations for CGT/ATMPs; practical experience bridging GCP–GLP–GMP interfaces. Proven decision quality under uncertainty and ability to influence program-level tradeoffs while maintaining compliance and scientific integrity. Hands-on leadership of audits (CROs, sites, specialty vendors, bioanalytical labs) and inspection readiness with successful outcomes. Excellent written and verbal communication; clear, concise reporting and executive level briefings.&nbsp; Preferred Qualifications&nbsp; Experience implementing RBQM, QTLs, and data driven quality metrics in CGT studies. ASQ CQA or equivalent auditor certification.&nbsp; The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$207,000&mdash;$253,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Director, Quality Assurance – Clinical and Nonclinical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Role Summary Prime Medicine is seeking an AI &amp; Informatics Engineer to join our AI Foundry and support our pipeline delivery.&nbsp; This includes designing and building the data and computational infrastructure that powers our prime editing programs. This role spans laboratory informatics, NGS pipeline development, and AI-enabled tooling, giving the right candidate a direct line from the work they do to the therapies we develop. You will partner closely with research scientists, computational biologists and technical development professionals, turning raw data into reliable scientific insights, and building automation and AI capabilities that let teams work faster and smarter. Our ideal candidate brings strong software engineering fundamentals, hands-on NGS pipeline experience, a practical understanding of modern AI frameworks, and the biological intuition to translate scientific needs into working systems. Equally welcome are candidates who entered this space from the life sciences side and have built serious software skills along the way. This is an action packed and dynamic role where the successful candidate will be involved in multiple programs and activities, so excellent organizational abilities, communications and strong collaboration are critical. The ideal candidate thrives when working in a fast-paced environment, working with purpose, and making an impact for patients. Key Responsibilities NGS Pipelines and Data Infrastructure Design, develop, and maintain scalable bioinformatics pipelines for NGS data analysis, including amplicon sequencing for on-target editing quantification, using Nextflow and Docker to ensure reproducibility. Build and maintain data infrastructure connecting NGS instruments, electronic laboratory notebooks (e.g., Benchling), data repositories, and AWS cloud compute, including automated data ingestion, scalable storage, and provenance tracking. Build APIs, MCPs, dashboards, and other internal tools that expose genomic data and analytical capabilities to scientific and cross-functional teams. Laboratory Informatics Support implementation and ongoing development of laboratory informatics systems, including data ingestion from key instruments and integration with laboratory data platforms such as Benchling. Support vendor relationships and delivery outcomes for external collaborators, driving requirements, managing implementations, and ensuring high-quality delivery. AI-Powered Tools and Automation Build AI-powered and agentic capabilities that automate routine work, support scientific reasoning, and improve how data and knowledge flow across the organization. Develop reusable platform components for retrieval, orchestration, and model interaction, with human-in-the-loop workflows that make AI systems transparent and practical for scientific users. Identify and address automation opportunities and scalability bottlenecks across research and operational workflows. Engineering Practices Write production-grade code using Git-based workflows, peer review, testing, CI/CD, and documentation best practices; convert research prototypes into robust, maintainable software. Build integrations between internal tooling and third-party platforms to support evolving scientific and operational needs. Participate in cross-functional projects spanning lab operations, software engineering, and bioinformatics; recommend best practices, system architectures, and design patterns. Perform code reviews and contribute to documentation of engineering and cross-functional practices. Qualifications Required BS with 5+ years or MS with 3+ years of industry experience in Engineering, Bioinformatics, Data Sciences, or a related field. Candidates with biotech or life sciences with substantial software experience are strongly preferred. Strong Python development; proficiency with Nextflow (or comparable workflow tools), Docker, AWS, Linux/Unix, and Git. Experience developing and deploying bioinformatic data infrastructure, particularly NGS analysis pipelines. Experience implementing or integrating laboratory informatics systems, preferably including Benchling. Experience developing and maintaining production-grade APIs and SDKs, and rolling out software tooling across an organization. Familiarity with LLM frameworks and practical judgment about where agentic approaches add genuine value. Track record of shipping software that scientific or technical users adopt and rely on. Preferred Experience building and deploying AI-powered tools or agentic systems in production or research settings. Familiarity with gene editing applications (CRISPR, base editing, or prime editing), including amplicon-seq workflows and tools such as CRISPResso. Familiarity with relational databases and data visualization tools (e.g., Plotly Dash, Streamlit, Spotfire). Experience in a GxP or regulated software environment (21 CFR Part 11, GAMP 5). Experience owning vendor relationships and delivery outcomes for external collaborators in laboratory informatics contexts. Why This Role Prime editing is a precise technology, and that precision depends on strong informatics, software, and scientific infrastructure. If you believe that better systems, better automation, and better access to data can translate into safer and more effective therapies, this is the right environment. You will build tools that directly shape how Prime generates, analyzes, and acts on scientific data, while helping lay the foundation for programs to come.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$134,000&mdash;$163,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

AI & Informatics Engineer

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op Assignment Overview Prime Medicine is seeking a Spring 2026 co-op with interest in large RNA molecule in-process analytics and purification to join the Chemistry team. The candidate will be involved in routine laboratory activities, including recording and taking UV absorbance measurements with NanoDrop, supporting purification, sample analysis by UPLC &amp; mass spectrometer (MS), and endotoxin testing of synthetic guide RNA. The candidate will learn a variety of in-process analytical techniques, gain proficiency in oligonucleotide characterization, support data generation and documentation, and present results at weekly team meetings. We welcome curious problem solvers who enjoy collaborative projects and are passionate about developing gene-editing technologies to improve human health and well-being.&nbsp; Key Responsibilities: Support characterization and purification of Prime’s long guide RNA (gRNA) using various laboratory techniques (e.g., ÄKTA purifier, UPLC, LC-MS, NanoDrop, endotoxin assays) Integrate chromatograms for gRNA crude, fraction, and final samples using Prime’s SOPs to quantify full-length product purity and tabulate the data in the team’s electronic lab notebook &nbsp; Learn &amp; contribute to mass analysis of gRNA to identify molecular weight of the full-length product and related impurities Assist senior scientists with buffer preparation, instrument maintenance, and development of up-to-date analytical methods to help increase in-process analytical capacity Oversee stock of critical reagents for buffer preparation to support purification and analytics Coordinate with scientists to manage inventory of the final released materials&nbsp; Required Qualifications:&nbsp; B.S. or M.S. candidate in Chemistry, Biochemistry, or related subjects; basic knowledge of organic chemistry preferred Prior completion of general chemistry and lab courses Excellent written and oral communication skills, strong organizational skills, ability to multi-task, and capacity to work independently or as part of a team &nbsp; A passion for learning and contributing across multiple facets of a program&nbsp; Preferred Qualifications: Relevant internship/Co-op experience Completion of analytical chemistry lecture and lab courses Familiarity working in a chemistry laboratory and experience with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure&nbsp; What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Spring 2026 Co-op: In-Process Analytics

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking a talented Senior Associate Engineer II for the Supply Chain and External Manufacturing organization to serve as a primary point of contact representing Prime Medicine for key external partners and support non-clinical development and CMC/manufacturing across Technology, Development &amp; Operations (TDO). This includes relationship and project management for CDMOs, CTLs, CROs and other critical suppliers. The role is focused on defining clear scopes of work, negotiating and managing SOWs/SOCs and change orders, proactively planning and managing risk, and ensuring tight alignment between internal teams and external partners. The ideal candidate is a highly creative and collaborative engineer with excellent project management skills, a roll-up-your-sleeve and solution-oriented attitude who is comfortable learning new things, wearing multiple hats, and operating in a fast-paced, evolving environment. This role reports to the Director of Supply Chain and External Manufacturing. Key Responsibilities 1. External Partnership, Relationship Management and Logistics Serve as the primary point of contact and project manager for assigned CDMO, CTL, CRO and other external partners across both non-clinical and CMC projects and activities. The position will be responsible for coordinating communications between Prime technical experts and external partners, prioritizing and facilitating external project team meetings. Establish and run effective meetings with partners and ensure timely communication and resolution of issues Coordinate with logistics providers and partners on shipment of materials, intermediates, and finished products between Prime and external sites ensuring compliance with relevant shipping and regulatory requirements (permits, customs, chain of custody, temperature control). Build strong, trust-based relationships and drive continuous improvement in performance and ways of working. 2. Internal Alignment, Scope Definition, Financial Management &amp; Communications Collaborate with stakeholders in Non-Clinical Development, CMC/Manufacturing and Quality, Program Management, Finance, Legal and others to align on objectives, expectations and priorities for external work. Translate program strategies into clear, actionable SOWs/SOCs with defined deliverables, timelines, and roles/responsibilities. Collaborate with Legal, Finance, Procurement and technical SMEs on MSAs, Quality/Technical Agreements, SOWs/SOCs and amendments. Own the operational aspects of SOW/SOC and change-order management Support budget tracking and financial planning for assigned vendors (forecasts, accrual inputs, and cost/risk trade-offs). Keep internal and external teams aligned as plans evolve with clear and concise documentation, as well as facilitating cross-functional meetings focused on execution and decision-making. 3. Project Management, Planning &amp; Risk Management, Process and Tools Develop and maintain integrated project plans for external workstreams aligned with overall program timelines and decision points. Monitor progress against milestones and KPIs and drive accountability to keep work on track. Develop and use dashboards and reporting to improve visibility into vendor performance, contract status, risks and key milestones. Proactively identify risks and dependencies, propose mitigation options, and maintain risk/issue/action logs. Embrace the use of AI and other digital tools to streamline workflows, improve decision-making, and accelerate execution Use LEAN and Six Sigma methodologies to develop and improve business processes Additional duties as assigned Qualifications BS/MS degree in Life Sciences, Chemistry, Engineering, Supply Chain, Business or related discipline; a background in STEM is preferred 4 - 6+ years of relevant industrial experience in biotechnology, pharmaceuticals, or cell and gene therapy, with significant exposure to non-clinical development and/or CMC/manufacturing. Direct experience managing external partners (e.g., CDMOs, CTLs, CROs), including project execution, relationship management, and issue resolution. Demonstrated experience with contracts, SOWs/SOCs and change orders, working closely with Legal, Finance and technical teams. Strong project management skills including planning, prioritization, tracking, and cross-functional coordination in a fast-paced, evolving environment. Familiarity with GxP environments and advanced therapy modalities (e.g., CGT) is strongly preferred. Fluent in the use of digital and AI-based tools to manage projects, data and documentation, with an interest in learning and experimenting with new tools as they evolve. A hands-on, “just roll up the sleeves” mindset that keeps programs and partnerships moving forward Excellent verbal and written communication skills; able to influence and align diverse stakeholders without formal authority. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$93,910&mdash;$114,778 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Associate Engineer II, Supply Chain & External Manufacturing

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Summary Prime Medicine is seeking a Senior Manager, Medical Writing to support the development of high-quality clinical, regulatory, and scientific documents across our gene-editing pipeline. This role will be both hands-on and strategic, contributing directly to authorship while helping to build scalable medical writing processes in a rapidly growing organization. Reporting to the Head of Medical Writing, this individual will partner closely with Clinical Development, Regulatory Affairs, Research, and other cross-functional teams to ensure accurate, consistent, and timely documentation supporting global clinical trials and regulatory submissions. This is an excellent opportunity for an experienced medical writer who thrives in a collaborative, fast-paced biotech environment and wants to grow into increasing leadership responsibility. Key Responsibilities Medical Writing &amp; Content Development Serve as primary author and/or lead writer for key clinical and regulatory documents, including: Clinical Study Protocols and Amendments Investigator’s Brochures (IBs) Clinical Study Reports (CSRs) IND/CTA submission documents and briefing packages Critically analyze and interpret nonclinical, clinical, and external literature data to develop clear scientific narratives, conclusions, and messaging. Ensure consistency of content, data interpretation, and scientific positioning across documents and programs. Cross-Functional Collaboration Work closely with Clinical Development, Clinical Operations, Regulatory Affairs, CMC, Nonclinical, and Quality teams to: Drive document timelines Resolve data and messaging questions Ensure regulatory and scientific alignment Lead and participate in cross-functional document review meetings and support responses to health authority questions as needed. Process, Quality &amp; Infrastructure Support the development and maintenance of: Medical writing templates, style guides, and standards Document workflows, timelines, and best practices SOPs and quality control processes Perform or oversee document QC, ensuring accuracy, clarity, formatting consistency, and compliance with internal standards and regulatory expectations. Evaluate and incorporate new writing support tools, including AI tools, to streamline processes and improve writing quality. Contribute to inspection readiness and submission quality initiatives. Leadership &amp; Development (scope dependent on level) May mentor junior writers, contractors, or co-ops as the team grows. Provide guidance on best practices in medical writing, document planning, and scientific storytelling. Required Qualifications Advanced degree or bachelor’s/master’s degree in life sciences, health sciences, or a related field. ~5+ years of medical writing experience in biotech/pharma OR ~7+ years of writing experience in biotech/pharma or other scientific or academic setting. Includes document ownership and cross-functional leadership Strong experience authoring clinical and regulatory documents (protocols, IBs, CSRs, IND/CTA content). Solid understanding of clinical development and regulatory frameworks (FDA, EMA, ICH). Excellent written, verbal, and organizational skills with strong attention to detail. Proficiency with document authoring tools (e.g., Microsoft Word, Office suite, SharePoint, Adobe). Preferred Qualifications Experience supporting gene editing/therapy or biologics programs. Familiarity with rare disease clinical development. Experience contributing to submissions across multiple development stages. Comfort working in a hands-on, fast-moving biotech environment. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$153,096&mdash;$188,095 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Manager, Medical Writing

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.&nbsp; A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.&nbsp; We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.&nbsp; Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives. &nbsp; Position Overview We are seeking a motivated, experienced, and collaborative scientific/technical leader to drive the development of analytical and QC-ready methods for lipid nanoparticle (LNP) formulated Prime Editor drug products (DP). Working as a member of a highly collaborative Technical Development / CMC organization, this individual will contribute to strategy and hands-on execution of method development to enable stage-appropriate development from early formulation/process development through clinical development stages, leveraging platform approaches when possible. This is a scientific leadership and hands-on role. The successful candidate will be responsible for developing, qualifying, and validating analytical methods for DP release and stability testing, as well as in-process control and characterization. The ideal candidate has a strong chemistry background (particularly lipids and lipid excipients), deep expertise in chromatography and LC-MS, and experience with LNP biophysical characterization (e.g., DLS), and stays abreast of innovations in the field for these and other techniques. Excellent communication skills—especially technical writing, including authoring analytical sections of regulatory submissions and responding to regulatory questions—are strongly preferred. Bioanalysis experience supporting preclinical studies using LC-MS is a plus. &nbsp; Key Responsibilities: Develop strategic plans and drive execution of analytical development activities for LNP DP programs, in alignment with program strategies Contribute to the development and refinement of the analytical control strategy, aligned with QTPP/CQAs and stage-appropriate development needs (early to late phase). Identify assay gaps, establish fit-for-purpose methods, and drive assay readiness for technology transfer and/or validation. Apply a strong understanding of LNP drug product–specific CQAs—including particle size/PDI, encapsulation efficiency, lipid and RNA composition, impurities and degradants, and stability-indicating attributes—to inform analytical strategy, method development, and control approaches. Develop and implement separation-based methods for LNP analytical characterization and lipid analytics Develop/optimize HPLC/UPLC/LC-MS methods for lipid components, impurities, degradants, and formulation-related analytes. Support assays for lipid identity/composition, residuals, and stability-indicating methods, as appropriate. Design and interpret forced degradation studies; support impurity/degradant identification; and evaluate stability trends to support control strategy and product understanding. Advance, optimize, and maintain chromatographic and/or electrophoretic methods for RNA analysis. Support biophysical characterization and orthogonal analytics for LNPs Develop/optimize DLS methods (particle size, PDI) and support complementary biophysical characterization techniques (e.g., zeta potential, particle concentration, morphology, and other orthogonal methods as needed). Interpret characterization data in the context of formulation/process changes, stability, and comparability. Regulatory documentation and inspection readiness Author, review, and approve protocols, SOPs, method reports, validation/verification documents, and CMC sections for regulatory submissions. Prepare written responses to regulatory information requests and support Health Authority interactions. Support DP release and stability testing, comparability evaluations, and technology transfer activities, as appropriate for development stage Support in-house and external DP release and stability testing activities. Provide technical oversight for external testing at CDMOs/CROs, ensure method performance, and review external data packages. Cross-functional collaboration and scientific communication Partner cross-functionally and contribute to timely decisions; communicate data, risks, and recommendations clearly. Data integrity and documentation excellence Maintain detailed and complete records in electronic lab notebooks and associated systems; ensure data integrity, traceability, and alignment with GxP expectations as programs progress. Contribute to continuous improvement of analytical workflows, LIMS/ELN utilization, and laboratory best practices. &nbsp; Qualifications: Education/Experience PhD in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with a minimum of 3 years of relevant industry experience; or BS/MS with 10+ years of relevant industry experience. Core technical expertise (highly preferred) Strong chemistry background, ideally with experience in lipids, lipid excipients, or related small-molecule chemistry. Deep hands-on experience with HPLC/UPLC method development (including troubleshooting, robustness, and stability-indicating methods). Strong experience with LC-MS (qualitative and/or quantitative), including method development and data interpretation for complex matrices. LNP characterization experience (preferred) Experience with DLS and interpretation of size/PDI trends; familiarity with other LNP-relevant techniques (e.g., zeta potential, particle concentration, cryo/TEM collaborations, DSC, spectroscopy, or other orthogonal tools depending on platform needs). Drug development and CMC mindset Experience developing analytical assays in a fast-paced, flexible CMC environment, using phase-appropriate qualification and validation strategies; ability to stay current with evolving regulatory guidance and pathways for innovative technologies. Regulatory document writing (preferred) Demonstrated ability to author technical documentation and contribute to regulatory submissions, and to respond to Health Authority questions with clear scientific justification. Bioanalysis experience (plus) LC-MS experience supporting preclinical bioanalysis (e.g., exposure/PK, tissue distribution, or related studies), including sample prep and quantitative workflows. Ways of working Demonstrated productivity and strong track record of delivery in a matrixed, fast-paced environment. Excellent written and verbal communication skills; ability to influence cross-functional stakeholders and mentor others. Passion for learning, strong problem-solving ability, attention to detail, and a commitment to scientific rigor and data integrity. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$145,080&mdash;$177,320 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Sr Scientist, Analytical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Position Summary We are seeking a highly motivated Senior Laboratory Operations Associate with 3–5 years of hands-on experience supporting high-throughput, high-hazard chemistry, vivarium, and GMP operations. This individual will play a critical role in ensuring the smooth operation of a dynamic laboratory environment. The ideal candidate has a deep understanding of management of high-volume high hazard chemicals, asset management, is adaptable, detail-oriented, and a strong cross-functional communicator with a passion for operational excellence. &nbsp; Key Responsibilities · Under the guidance of the Senior Laboratory Manager, manage day-to-day operations in high-volume chemistry, biology, animal, and GMP laboratories, including supply management, asset management, chemical inventory, and waste handling. · Oversee management and administration of laboratory instrument service agreements, remedial repair, scheduling preventative maintenance, and digital asset management system. · Manage relationship with select vendors and suppliers. · Oversee the receipt, organization, and distribution of reagents and consumables to support chemistry workflows including 55-gallon drums of virgin chemicals and waste. · Ensure appropriate segregation, labeling, storage, and disposal of high-hazard chemicals, including Class A, Class B, water reactive materials, organic acids, inorganic acids, bases, and acutely toxic chemicals. · Coordinate with chemists to prepare and dispose of solid-phase resins, solvents, and purification materials in compliance with EHS protocols. · Monitor and maintain process systems and chemicals in 780 CMR/International Building Code (IBC) §307 designated High-Hazard Group Occupancy (H3 room). · Collaborate with vivarium staff to support animal research workflows, including supply delivery, sanitization cycles, live animal deliveries, and carcass disposal in accordance with 105 CMR 480.000. · Support cross-functional workflows between R&amp;D and GMP labs. · Ensure documentation, materials movement, and environmental monitoring align with GMP compliance expectations. · Other responsibilities as required. &nbsp; Qualifications Education &amp; Experience · 3–5 years of direct hands-on experience in laboratory operations within a biotechnology environment. · Experience supporting high-hazard chemistry, vivarium operations, GMP manufacturing, and BSL-2 biology labs. &nbsp; Required Skills &amp; Competencies · Experience working in ISO 5, 7, and 8 cleanroom environments. · Experience with ‘just-in-time’ supply chain management, KANBAN, 5S/Lean. · Familiarity with lab and facility management systems (e.g., LIMS, CMMS, asset management). · Comfortable working in environments requiring strict compliance: H3 occupancy, BSL-2, vivarium, and GMP. · Strong organizational and multitasking skills with an ability to work independently. · Excellent communication skills, both verbal and written. · Familiarity with 527 CMR 1.00, RCRA, EPA, DOT, HAZWOPPER, and IATA regulations. &nbsp; Physical Requirements · Ability to be on-call to receive and respond to alarms within 1 hour. · Ability to lift 50lbs, stand for extended periods, and perform repetitive physical tasks. · Comfortable working with hazardous materials while wearing appropriate PPE including the Advantage 420 Respirator, Tyvek Full GMP Sterile Coverall, lab coat, and ‘silvershield’ gloves. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$82,010&mdash;$113,300 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Laboratory Operations Associate

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.We are seeking a Senior Scientist, Biomarkers Key Responsibilities Biomarker Strategy &amp; Scientific Leadership Lead fluid biomarker strategy for clinical programs, ensuring alignment with clinical objectives, regulatory expectations, and translational hypotheses. Design and oversee development, qualification, and validation of biomarker assays at CROs and external laboratory partners. Provide scientific oversight for assay selection, fit-for-purpose validation, and performance monitoring. Contribute to clinical protocol development, statistical analysis plans, and regulatory documents (e.g., INDs, briefing books). Assay Development &amp; Validation Direct development and validation/qualification of blood-based and other fluid biomarker assays (e.g., protein, enzymatic, molecular assays). Ensure assays are developed under appropriate regulatory frameworks (GLP/GCLP/CLIA as applicable). Evaluate assay performance characteristics including sensitivity, specificity, precision, robustness, and stability. Troubleshoot assay performance issues and implement corrective actions. Clinical Study Execution Partner closely with clinical operations and sample management teams to ensure seamless biomarker sample collection, handling, and analysis. Collaborate with peers responsible for immunogenicity and PK assays to ensure integrated PK/PD and biomarker analysis. Oversee data generation timelines, budgets, and vendor performance. Lead scientific review and interpretation of biomarker data to support internal decision-making. Cross-Functional Collaboration Work closely with Clinical Development, Regulatory, Biostatistics, CMC, and Research teams. Contribute to cross-program biomarker governance and best practices. Represent the Biomarkers group in cross-functional team meetings and external vendor discussions. Data Analysis &amp; Interpretation Perform and/or oversee robust statistical and scientific analysis of biomarker data. Integrate biomarker findings with clinical endpoints and PK data. Prepare high-quality summaries and presentations for internal governance and external regulatory interactions. &nbsp; Qualifications Education &amp; Experience PhD in Immunology, Molecular Biology, Biochemistry, Translational Medicine, or related discipline with 4+ years of industry experience; or MS with 8+ years of relevant industry experience. Demonstrated experience supporting clinical-stage programs. Technical Expertise Strong experience in assay development and fit-for-purpose validation (protein, enzymatic, or molecular assays). Hands-on experience managing assay development at CROs and external laboratories. Deep understanding of GCLP/GLP principles and regulatory expectations for clinical biomarker assays. Experience with blood-based biomarker assays required. Familiarity with PK/PD concepts and translational biomarker strategy strongly preferred. Scientific &amp; Analytical Skills Strong data analysis skills and ability to interpret complex biomarker datasets. Experience contributing to regulatory submissions (INDs, briefing documents, clinical study reports) preferred. Ability to critically evaluate assay performance and scientific rigor. Leadership &amp; Operational Skills Demonstrated ability to manage external vendors and timelines. Strong time and resource management skills. Ability to operate independently while thriving in a collaborative, cross-functional environment. Excellent written and verbal communication skills. &nbsp; Preferred Qualifications Experience in rare disease programs. Experience with genetic medicine or gene editing platforms. Experience supporting first-in-human studies. Exposure to multiplexed, LC/MS-based, or advanced molecular biomarker platforms. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$145,000&mdash;$177,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Scientist, Biomarkers

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Prime Medicine Co-op: Automation Manager: Jack De Groot (Spring Cycle July-December 2026) Co-op Assignment Overview Prime Medicine is seeking a co-op for the Fall 2026 cycle with experience in life sciences and/or engineering to join the Automation Core team. The candidate will work within a highly collaborative team, supporting a variety of departments and groups through the maintenance and operation of Prime’s automation portfolio. The prime candidate will work with automation focused on plate-based assays, high-throughput screening, NGS, and LNP formulation, where they will learn to bridge the gap between bench-based development and robotic implementation while supporting a growing automation portfolio. Primary Responsibilities: · Active system maintenance of current integrated robotic systems · Development of high-impact protocol designs and SOPs · Work with scientists and engineers to design and coordinate proof of concept experiments for new ideas and equipment · Assist with general lab organization, such as lab cleanliness, consumable tracking and arrangement, moving equipment to optimize prioritized needs, etc… · Aseptic cell culture · Data analysis, interpretation, and presentations within the team Qualifications: · B.S./M.S. candidate in Biology, Life Sciences, or Engineering · Basic programming skills and an avid interest in lab automation. Knowledge of basic biology and experience with liquid handling automation (especially Tecan) preferred · Excellent troubleshooting and communication skills · Ability to work independently and within a team &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Automation

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com. Fall 2026 Co-op Program: July – December 2026 Co-op Title: Off-Target analysis of Gene Editing Manager Name: Angela Guo Department: Off-target Biology &nbsp; Assignment Overview Prime Medicine is seeking a highly motivated co-op to join the Off-target biology team supporting Prime Editing programs. This role will contribute to the safety evaluation of Prime Medicine’s gene editing therapies. The candidate will work at the interface of cell biology, genome editing, next-generation sequencing (NGS), and Molecular Biology. The coop will work with a scientist to support their off-target analysis of pre-clinical gene editing programs. This will include, cell biology, molecular analysis of Prime Editing components, and next generation sequencing of Prime Editing outcomes. In addition to supporting ongoing work the Co-op will be able to develop a defined project and will work closely with other teams such as Computational Sciences and Screening. This position offers hands-on experience with cutting-edge gene editing technologies in a fast-paced, collaborative R&amp;D environment focused on developing transformative genetic medicines. We seek a driven team member passionate about advancing human health. Primary Responsibilities: · Perform cell transfections and execute gene editing experiments · Isolate genomic DNA, prepare NGS libraries, and operate Illumina sequencing platforms · Analyze PE activity in cells including ELISAs and other assays · Maintain cell lines in culture and become adept at cell handling · Analyze and interpret sequencing data · Maintain accurate experimental documentation using an electronic lab notebook system &nbsp; Qualifications: · Pursuing a B.S. or M.S. in Molecular Biology, Genetics, Bioengineering, or related field · Hands-on experience with core molecular biology techniques, including PCR and DNA extraction · Experience with aseptic technique · Familiarity with genome editing concepts · Exposure to NGS workflows or sequencing-based assays · Strong attention to detail, troubleshooting ability, and collaborative mindset &nbsp; Preferred Qualifications: · Prior mammalian cell culture experience strongly preferred · Hands-on experience with gene editing and/or NGS techniques · Experience with laboratory automation and/or data analysis The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Off-Target Analysis of Gene Editing

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Fall 2026 Co-op Program: July – December 2026 Co-op Title: Screening &amp; On-target NGS Manager Name: Sarah Trusiak&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Department: Screening &amp; NGS &nbsp; Assignment Overview Prime Medicine is seeking a highly motivated co-op to join the Screening &amp; NGS team supporting Prime Editing programs. This role will contribute to high-throughput genome editing experiments in mammalian systems and sequencing-based evaluation of editing outcomes. The candidate will work at the interface of cell biology, genome editing, next-generation sequencing (NGS), and lab automation. In addition to supporting active screening efforts, the co-op will lead a defined project to optimize and automate components of the screening workflow to improve throughput, reproducibility, and data quality. This position offers hands-on experience with cutting-edge gene editing technologies in a fast-paced, collaborative R&amp;D environment focused on developing transformative genetic medicines. We seek a driven team member passionate about advancing human health. &nbsp; Primary Responsibilities: Maintain and manipulate mammalian cell cultures using aseptic technique Perform cell transfections and execute gene editing experiments Isolate genomic DNA, prepare NGS libraries, and operate Illumina sequencing platforms Support development of automated liquid handling workflows Analyze and interpret sequencing data to assess editing efficiency and screening performance Maintain accurate experimental documentation using an electronic lab notebook system &nbsp; Qualifications: Pursuing a B.S. or M.S. in Molecular Biology, Genetics, Bioengineering, or related field Hands-on experience with core molecular biology techniques, including PCR and DNA extraction Experience with aseptic technique Familiarity with genome editing concepts Exposure to NGS workflows or sequencing-based assays Strong attention to detail, troubleshooting ability, and collaborative mindset &nbsp; Preferred Qualifications: Prior mammalian cell culture experience strongly preferred Hands-on experience with gene editing and/or NGS techniques Experience with laboratory automation and/or data analysis The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Screening & On-target NG

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Fall 2026 Co-op Program: July – Dec 2026 Manager: Dorjee Shola Department: lung biology _____________________________________________________________________________________ Co-Op Assignment Overview Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in animal- and cellular-based studies to join the Lung Biology team. The candidate will be involved in supporting critical efforts in identifying delivery candidates for lung-directed dosing in animals towards the development of in vivo gene editing therapies that leverage our cutting-edge Prime Editing technologies. The successful candidate will thrive in a fast-paced research program and will enjoy working with colleagues within and across teams from multi-disciplinary backgrounds. Primary Responsibilities: · Assist and support lung delivery in-vivo studies, include dosing, takedown, tissue processing and antibody staining · Plan and execute in vitro assays to evaluate gene editing activity in relevant cell models including primary lung bronchial epithelial cells · Follow protocols, standard operating procedures, execute assigned tasks and maintain ELN. Share responsibility in lab reagent inventory and maintaining equipment. · Work and collaborate cross-functionally with colleagues. Collect, analyze and present data in team meetings. Required Qualifications: · Bachelor/Master candidate in Biology related major · Direct experience performing routine laboratory procedures and experiments · Hands on experience with sterile techniques and culturing of mammalian cell culture including primary cells · Comfortable working with rodent models with preliminary techniques or training on animal studies is a plus Preferred Qualifications: Experience with the following techniques or knowledge familiarities are preferred. · Gene editing technologies (Cas9, base editing, prime editing etc) · Non-viral delivery · Animal dosing techniques (IV, IP, Oral, etc) · Lung tissue processing, and cell staining for flow analysis &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: In-Vivo Delivery

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op: Clinical Development - Patient Advocacy and Medical Affairs Location: Cambridge, MA Co-Op Assignment Overview Prime Medicine is seeking a co-op student to join the Patient Advocacy and Medical Affairs team. This individual will support efforts to build strong relationships with patient communities and collaborate with patient advocacy organizations across Prime’s therapeutic programs. The co-op will contribute to initiatives that integrate the patient perspective into clinical and regulatory strategy. The role will also provide exposure to core medical affairs activities, including conference and publication planning, Key Opinion Leader (KOL) engagement, and clinical study support as it relates to patient engagement. The ideal candidate will be highly motivated, thoughtful, and collaborative, with the ability to engage respectfully with internal and external stakeholders. They will have a strong interest in rare diseases, genetic medicines, and advancing patient-focused drug development. Primary Responsibilities Support Prime Medicine’s patient advocacy strategy and “Patients First” initiatives across therapeutic programs Conduct landscape research on patient advocacy organizations, rare disease communities, and relevant stakeholder groups Assist in preparing educational materials for patient communities related to genetic medicines and clinical development Assist in planning and preparation for Patient Advisory Boards, and synthesis of key insights to help inform patient engagement and clinical development strategies. Draft responses to patient and caregiver inquiries, ensuring accurate, timely, and compliant communication. Assist with KOL engagement, conference/publication and external presentation planning activities as needed. Participate in cross-functional meetings to gain exposure to clinical strategy, regulatory planning, and stakeholder engagement &nbsp; Qualifications Currently pursuing a B.S. or B.A. in Public Health, Biology, or Health Sciences field Strong interpersonal, oral, and written communication skills Ability to manage multiple projects and work both independently and within a team environment Proficiency in Microsoft Office (PowerPoint, Excel, Word) &nbsp; Preferred Qualifications Coursework in medical sciences or familiarity with medical terminology Interest in rare diseases, genetic therapies, or patient engagement Exposure to scientific communication, public health, advocacy, or healthcare policy Basic understanding of clinical trials and drug development processes &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$29 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Clinical Development - Patient Advocacy and Medical Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Co-Op Assignment Overview Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in molecular/cell biology-related wet-lab work to join the Prime Editing Platform team. The candidate will contribute to the development of RNA innovations that advance Prime Medicine’s platform capabilities. The qualified candidate will work with a highly collaborative, fast-paced team to design, screen, optimize and validate Prime Editor mRNAs in relevant cell models to support and expand mRNA-based screening efforts. In parallel, the candidate will help drive the exploration and development of RNA modalities across the organization. The candidate will receive consistent mentorship from experienced scientists and learn a variety of different lab-based techniques and skills. Furthermore, the co-op will learn about data analysis and will have an opportunity to present his/her/their work in team meetings. In this position, the candidate will develop a deep understanding of RNA technologies and gene editing and how these efforts fit into the overall drug discovery process. Primary Responsibilities: · Conduct mRNA production via in-vitro transcription (IVT) and purification. · Maintain mammalian cell culture, perform cell passaging. · Transfect mammalian cells with Prime Editing reagents to determine gene editing activity. · Execute and develop routine cell-based assays to screen for novel mRNA constructs. · Perform analytical procedures including ELISA, luciferase assay, qRT-PCR assay and gDNA. · Maintain a timely and well-organized electronic lab notebook (ELN). · Provide preliminary data analysis, interpretation, and contribute to presentations within Platform team and cross functional teams. Required Qualifications: · B.S. /M.S. candidate in in Cell &amp; Molecular Biology, Chemical Biology, Biochemistry, or related majors. · Firm understanding of, molecular biology, cell biology, and biochemistry. Background understanding of genome editing is a plus. · Previous wet-lab (molecular/cell biology) experience. · Excellent troubleshooting and communication skills. · Interested in solving complex problems in a cross functional collaborative environment. Preferred Qualifications: · Familiar with cell-based assays, mammalian cell culture and transfection, and nucleic acid biochemistry. · Excels at some of the following lab techniques: PCR, nucleotide extraction, molecular cloning, ELISA, etc. · Ability to use Word, Excel, PowerPoint, and GraphPad Prism for data documentation, analysis, and presentation. · Experience with computational molecular biology tools (e.g., DNA visualization software) &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Platform Technologies & Innovation

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op: Analytical Development Manager: Minjia Wang (Fall 2026 Cycle) Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replace the segment of faulty DNA with a correct copy of DNA. A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations. We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefits to patients. Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with a diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives. Co-op Assignment Overview Prime Medicine is seeking a diligent, motivated, and enthusiastic co-op for the Fall 2026 cycle who has interest in state-of-the-art analytical technologies including HPLC, LC-MS, and capillary electrophoresis to join the analytical development (AD) team. The successful candidate will be able to participate in the development of separation-based analytical methods for the Prime Editor delivery platform and work cross-functionally to advance the Prime pipeline. Also, this co-op student will have hands-on opportunities to gain exposure to a broader range of analytical techniques (such as flow cytometry), gaining familiarity with scientific and regulatory requirements for phase-appropriate analytical testing. There will also be valuable opportunities to participate in other cross-functional projects that are crucial to the success of in vivo and ex vivo gene editing therapeutic drug development. Primary Responsibilities: Participate in separation-based method (HPLC, LC-MS) development to assess lipid nanoparticle (LNP) drug products and their components. Assist senior-level scientists with buffer preparation, maintenance of instruments, and developing up-to-date analytical methods that help to increase in-process analytics capacity. Participate in cell-based method (flow cytometry) development to assess cell therapy drug products. Support the maintenance of instruments. Support the phase-appropriate product development (PD) sample analyses, release testing, and stability studies for the characterization and release of cell and gene therapy drug products, drug substances, and critical raw materials. Document, present, and communicate experimental data and conclusions in an electronic notebook, following cGMP documentation practices. Data analysis, interpretation, and presentation within the team. Qualifications: Currently enrolled in a B.S. or M.S. program in biochemistry, chemistry, chemical engineering, pharmaceutical science, or a related field. Basic knowledge of separation sciences and technologies. Ability to handle multiple projects in a fast-paced environment. Excellent troubleshooting and communication skills. Ability to work independently and within a team. Skilled in documenting findings and activities in comprehensive reports and ensuring proper inventory of materials and analytical equipment. Preferred Qualifications: Hands-on experience with LC-MS, capillary electrophoresis, and/or cell culture is preferred. Previous co-op experience in the biotechnology industry. Independently motivated, detail-oriented, and excellent problem-solving abilities. What We Offer: A cutting-edge scientific team dedicated to mentorship and networking Experience in the field of gene editing and analytical development/early-stage QC Participation in regular scientific seminars with industry experts The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Analytical Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Fall 2026 Co-op: Quality Control Co-Op Assignment Overview Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in biological and/or chemical techniques to join the Analytical Development and Quality Control (QC) team. The candidate will gain hands-on experience supporting analytical testing for gene therapy programs, including prime editing components, drug substances, and drug products. This co-op will learn cutting-edge analytical technologies, develop an understanding of scientific and regulatory requirements for phase-appropriate analytical testing, and contribute to solving complex technical challenges related to prime editing programs. This is a unique opportunity to directly support the advancement of transformative genetic medicines toward the clinic. We are looking for curious problem solvers who enjoy working collaboratively, thrive in a fast-paced environment, and are passionate about advancing genetic editing technologies to improve human health. Primary Responsibilities Support product development sample analyses, in-process, release, and stability testing for LNP-based drug products, prime editing component RNAs, and cell-based drug products. Execute and support cell-based analytical activities. Perform cell-based potency, viability, conduct cell counting. Assist with optimization, troubleshooting, validation, and qualification of analytical methods. Participate in stability and reference standard programs including protocol/report preparation, data compilation, trending, and analysis. Assist with sample management and chain-of-custody documentation. Conduct clean room laboratory environmental monitoring for GMP manufacturing suites. Document and communicate experimental data in electronic notebooks and quality systems in accordance with cGMP requirements. Collaborate cross-functionally with Analytical Development, Manufacturing, MSAT, and Program Teams to support product and method development and qualification/validation. Contribute to laboratory functionality, safety compliance, and QC process optimization. Identify opportunities for assay optimization, workflow improvements, and automation. Demonstrate flexibility in supporting new projects, troubleshooting activities, and evolving program priorities. Qualifications Currently enrolled in a B.S. or M.S. program in Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, Chemistry, Chemical Engineering, Pharmacology, or related field. Completion of foundational biology, biochemistry, microbiology, chemistry, and/or cell biology coursework with laboratory components. Experience with aseptic technique and basic cell culture is highly desirable, or liquid nanoparticle technology. Ability to work both independently and collaboratively. Self-motivated, detail-oriented, and organized with strong problem-solving skills. Excellent verbal and written communication skills. Eagerness to learn GLP/GMP practices and analytical methodologies. Comfortable engaging in cross-functional teamwork. Ability to manage multiple projects in a dynamic, fast-paced environment. Preferred Qualifications Understanding of fundamental principles behind biological and chemical analytical techniques such as UV-Vis, HPLC/UPLC, LC-MS, PCR/qPCR/ddPCR, and potency assays. Hands-on experience with biological or chemical analytical techniques including sample preparation, dilution, extraction, and analysis. Experience with cell-based assays (e.g., viability assays, flow cytometry, functional assays). Familiarity with cell therapy or gene editing technologies. Prior internship or co-op experience in the biotechnology industry. What We Offer A cutting-edge, collaborative team committed to mentorship and professional development. Exposure to gene and cell therapy analytical strategies in a GMP-regulated environment. Participation in seminars with industry experts. Note: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Quality Control

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Co-op: Automation &amp; Assays (Fall July-December 2026) Co-op Overview Prime Medicine is seeking a motivated and detail-oriented Co-op Student to join our Automation &amp; Assays team for a 6-month term. This is a hands-on role that offers exposure to cutting-edge automated laboratory systems and a wide range of biochemical and cell-based assays in support of research and process development activities across the company. You will work alongside experienced scientists to learn, develop, and execute assays on automated liquid handling platforms, contributing directly to programs that are advancing gene editing therapies toward patients. Primary Responsibilities: Learn and execute biochemical and cell-based assays (including ELISAs and related methods) to test samples in support of research and process development programs Operate and maintain automated liquid handling systems (e.g., Hamilton, Tecan) to run high-throughput workflows Maintain accurate and detailed records of experimental work in accordance with good laboratory practices Analyze and interpret experimental data, contributing to summaries and reports; scripting experience (Python, R) is a plus for data processing tasks Work cross-functionally with research and process development teams to support ongoing project needs Contribute to continuous improvement of assay protocols and automation workflows Qualifications: Currently enrolled in a Bachelor's or Master's program in Biology, Biochemistry, Bioengineering, Biomedical Engineering, or a related field, with at least 2 years of undergraduate coursework completed Hands-on wet lab experience, including proficiency in pipetting, cell culture, and aseptic technique Strong attention to detail and a commitment to data integrity Ability to manage time effectively, prioritize tasks, and work independently in a fast-paced environment A collaborative, curious mindset and a genuine passion for science Nice-to-haves: Prior experience with automated liquid handling systems (e.g., Hamilton, Tecan) Familiarity with ELISA or other biochemical assay formats Experience with data analysis or scripting tools (Python, R) Previous co-op, internship, or research lab experience in an industry or academic setting The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Automation & Assays

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Fall 2026 Co-op: In-Process Analytics Co-op Assignment Overview Prime Medicine is seeking a Fall 2026 co-op to join our Chemistry team, with a focus on in-process analytics and purification of large RNA molecules. The successful candidate will engage in hands-on laboratory work, including UV absorbance measurements using NanoDrop, purification support, sample analysis by UPLC and mass spectrometry (MS), and endotoxin testing of synthetic guide RNA. Through this experience, the co-op will develop proficiency in oligonucleotide characterization, gain exposure to a broad range of in-process analytical techniques, contribute to data generation and documentation, and present findings at weekly team meetings. We welcome curious, collaborative problem solvers who are passionate about advancing gene-editing technologies to improve human health. Primary Responsibilities Support the characterization and purification of Prime's long guide RNA (gRNA) using a suite of laboratory techniques, including ÄKTA purifier, UPLC, LC-MS, NanoDrop, and endotoxin assays Integrate chromatograms for gRNA crude, fraction, and final samples in accordance with Prime's SOPs to quantify full-length product purity, and tabulate results in the team's electronic lab notebook Learn and contribute to mass analysis of gRNA to identify the molecular weight of the full-length product and related impurities Assist senior scientists with buffer preparation, instrument maintenance, and the development of updated analytical methods to expand in-process analytical capacity Manage inventory of critical reagents for buffer preparation in support of purification and analytics operations Coordinate with scientists to maintain inventory records for final released materials Required Qualifications Enrolled in a B.S. or M.S. program in Chemistry, Biochemistry, or a related field; basic knowledge of organic chemistry preferred Prior completion of general chemistry coursework and associated laboratory courses Strong written and oral communication skills, with excellent organizational ability and capacity to work both independently and collaboratively Enthusiasm for learning and contributing across multiple aspects of a research program Preferred Qualifications Prior internship or co-op experience in a relevant setting Completion of analytical chemistry lecture and laboratory courses Hands-on experience in a chemistry laboratory, with familiarity with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure What We Offer A cutting-edge, mentorship-driven team with strong networking opportunities Full reimbursement for monthly commuting costs, including MBTA, Commuter Rail, and Bluebikes Access to regular seminars featuring industry experts Full participation in company-wide activities, including learning and development programming, social events, and more &nbsp; Please note: We are currently only considering candidates based in the greater Boston/Cambridge area.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: In-Process Analytics

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Spring 2026 Co-op: LNP Process Development Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester to work in a cross-functional LNP formulation and process development team. The candidate will work with formulation scientists, process development engineers, and chemical engineers to optimize mRNA and LNP formulation and processes related to the manufacture of LNPs. The candidate will gain hands-on experience with various LNP formulation techniques and processes, analytical and biophysical characterization, and play a critical role in solving challenging problems associated with LNP formulation and process development.&nbsp;&nbsp;&nbsp;&nbsp; We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being. Primary Responsibilities: Collaborate with the LNP formulation and process development team, and cross-functional teams to execute experiments supporting Prime Medicine goals Execute experiments to optimize and understand the robustness of LNP formulations and related processes Perform analytical testing for assessing LNP formulations and payload quality as it relates to critical process parameters Effectively communicate results to internal and external meetings, and present the final summary to the team Document and manage all experimental planning and progress in electronic lab notebook in an organized manner, providing statistical analysis and troubleshooting where appropriate. Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies. Qualifications: S./M.S. candidate in Chemical Engineering, Chemistry, Bioengineering or Biochemistry Prior wet lab experience with processes and methods of making and testing LNPs is preferred. Prior Co-Op experience(s) is preferred. Knowledge of mixing techniques, tangential flow filtration, and characterization techniques (DLS, plate based assays, HPLC) for LNPs Familiarity with DOE is a plus Excellent written and verbal communication skills. Curious, ability to work independently or collaboratively as needed Self-motivated, detail-oriented with strong critical thinking skills and excel at identifying and solving problems. What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: LNP Process Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Fall 2026 Co-op: Small Scale Guide RNA Chemistry Co-op Assignment Overview Prime Medicine is seeking a Co-op for the Fall 2026 semester to join our guide RNA chemistry team. The ideal candidate will have a strong foundation in chemistry or biochemistry and will contribute to the synthesis, cleavage and deprotection, purification, and analysis of long guide RNA oligonucleotides. In this role, you will gain comprehensive, hands-on experience in solid-phase synthesis, purification, desalting, lyophilization, and analysis of long oligonucleotides in direct support of our prime editing programs. Primary Responsibilities Support solid-phase synthesis of oligonucleotides using automated DNA/RNA synthesizers, including the Mermade12 Assist with HPLC purification and UPLC/LC-MS analysis of research-scale long oligonucleotides Prepare buffers and solutions for guide RNA purification and analysis Track and manage inventory of chemicals, reagents, and consumables, including coordinating orders as needed Assist with the maintenance and troubleshooting of laboratory equipment, including synthesizers, SpeedVacs, lyophilizers, and HPLC instrumentation Maintain thorough and accurate records in an electronic laboratory notebook (ELN); track progress, analyze and interpret data, and present findings to both the immediate team and cross-functional stakeholders Conduct all laboratory work safely and efficiently, upholding a safe working environment for all colleagues Qualifications Currently pursuing a B.S. in Chemistry, Biochemistry, or a related field; a foundational understanding of organic chemistry is preferred Prior hands-on experience in a chemistry or biochemistry laboratory High degree of self-motivation and adaptability in a fast-paced environment, with strong organizational skills and the ability to prioritize tasks and meet deadlines Proficiency in common computer applications, including Microsoft Excel, Word, and PowerPoint Strong troubleshooting and communication skills Demonstrated ability to work both independently and collaboratively within a team Preferred Qualifications Prior experience in nucleic acid chemistry Hands-on experience with HPLC, UPLC, and/or LC-MS instrumentation What We Offer A collaborative, cutting-edge team committed to mentorship and professional networking Full reimbursement of monthly commuting costs, including MBTA, Commuter Rail, Bluebikes, and more Participation in regular seminars featuring industry experts Full access to employee programming, including learning and development initiatives, social events, and more &nbsp; NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$23&mdash;$29 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Small Scale Guide RNA Chemistry

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Director, People and Culture Business Partner Location: Cambridge and Watertown, MA (between two sites at least 3 days a week) Reports To: VP, Senior People and Culture Business Partner Who We Are At Prime Medicine, we're not just editing genes — we're rewriting what's possible for patients living with debilitating genetic diseases. Built on the groundbreaking Prime Editing platform, a next-generation "search and replace" technology, we are on a mission to deliver potentially curative therapies to patients who have waited long enough. Our team of scientists, engineers, and operators is intensely curious, deeply collaborative, and united by a shared belief: that the right science, paired with the right people, can change the course of disease. We move fast, think boldly, and take our work seriously — while making sure we enjoy the journey together. This is a pivotal moment for Prime Medicine. We are focused, energized, and building toward breakthroughs that matter. If you want to do the most meaningful work of your career alongside people who feel the same, you've found your place. The Opportunity Prime Medicine is seeking a Director, People and Culture Business Partner — a passionate, people-first HR professional who is as comfortable shaping culture as they are rolling up their sleeves on the operational fundamentals that keep a growing biotech humming. Reporting to the VP, Senior People and Culture Business Partner, you'll be a trusted partner to Prime's management and employees alike - someone who connects deeply with the business, champions our culture, and helps ensure our people strategy keeps pace with our science. At Prime, People &amp; Culture is a strategic driver of our mission. This role is for someone who works hard, has fun, and genuinely believes that great organizations are built one person, one team, and one conversation at a time. &nbsp; What You'll Do Be a Culture Champion Show up as the heart of our employee experience — approachable, credible, and genuinely invested in the people you work with. Partner with managers and employees to reinforce and evolve Prime's culture and values as the company grows. Support employee engagement initiatives and translate listening efforts (surveys, conversations, data) into meaningful action. Help to continue to make Prime the kind of place where brilliant people do their best, most fulfilling work. Drive Talent Strategy Identify development opportunities that deepen our talent bench and build organizational capability for the long term. Support creative career pathing efforts and employee development programs that reflect Prime's startup spirit and scientific ambition. Serve as a true Talent Ambassador — someone employees, management, external vendors and candidates are excited to engage with. Partner Strategically with the Business Partner closely with management to drive organizational effectiveness, workforce planning, and thoughtful change management. Translate Prime's evolving business priorities and values into people strategies that create real impact. Lead organizational design efforts and guide teams through change with clarity and care. Provide counsel that's both candid and compassionate on employee relations and management challenges. Execute with Excellence Ensure flawless execution of core HR cycles: administration, compensation planning, promotions, talent mobility, headcount planning, recruitment, and workforce planning. Partner with Total Rewards to navigate compensation cycles effectively and equitably. Contribute to policy development and evolving compliance needs as Prime scales — with a pragmatic, startup-savvy lens. What You Bring An advanced degree in Human Resources, Business, Life Sciences, or a related field. 10–12+ years of progressive HR experience, with significant HRBP experience supporting managers and employees. Deep experience in biotechnology, pharmaceuticals, or life sciences — you understand the cadence, culture, and complexity of science-driven organizations. A startup mentality with an operator's mindset: you know when to build from scratch, when to borrow a best practice, and when to just get it done. Demonstrated success juggling multiple priorities in a fast-moving environment without losing sight of the details or the people. Strong business acumen and executive presence — you influence at all levels, and people trust your judgment. A high tolerance for ambiguity, a bias toward action, and a track record of driving measurable outcomes. You work hard, have fun, and make the team around you better. Why Prime Medicine Mission that matters: Every program we advance has the potential to change — or save — a life. You'll feel that every day. A team you'll love: brilliant, humble, fun people who take the science seriously A pivotal moment: Prime is a focused, forward-moving company with a clear path and bold ambitions. You'll help shape what comes next. Cambridge at its best: Sit at the epicenter of the world's most dynamic biotech ecosystem. A seat at the table: People and Culture is a strategic partner here. Your voice will be heard and your impact will be real. Prime Medicine is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment where all employees can thrive.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$180,000&mdash;$220,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Director, People and Culture Business Partner

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; (Fall 2025 Cycle: July-Dec 2026) Co-Op Assignment Overview Prime Medicine is seeking a co-op for the Fall 2026 semester with experience and/or knowledge in natural science such as Biology, Chemistry or other biotech-related disciplines to join the Regulatory Affairs team. The Prime Medicine Regulatory Affairs team is a tight-knit, closely collaborative, highly creative group working to make the promise of Prime Editing a reality for patients with severe genetic diseases. The qualified candidate will be highly motivated, analytical and collegial. The candidate will support the Regulatory Affairs team in ensuring compliance with relevant regulations and guidelines relevant to the company's gene editing pipeline programs for patients with genetic diseases. You will assist in researching, interpreting, and implementing regulatory requirements, as well as providing administrative support for regulatory submissions and documentation. &nbsp; Primary Responsibilities: · Conduct research on regulatory requirements pertinent to the company's product pipeline. Stay updated on changes in regulations and guidelines affecting the industry. &nbsp; · Assist in maintaining regulatory documentation, spreadsheets, and trackers related to the compilation of required inputs for regulatory submissions. Ensure all documents and trackers are organized and up to date. &nbsp; · Support the preparation, compilation, and submission of regulatory documents to FDA and ex-US regulatory agencies. This may include applications for regulatory agency meetings, drug designations, and/or investigational new drug applications. &nbsp; · Assist in monitoring compliance of clinical-stage development programs with regulatory requirements and adherence to regulations. &nbsp; · Cross-functional collaboration with other departments, such as R&amp;D, preclinical, and clinical teams to gather information and help ensure regulatory compliance in product development, testing, and regulatory submission packages. &nbsp; · Assist in preparing regulatory reports and responses to regulatory inquiries. &nbsp; · Participate in training sessions and educational programs to enhance understanding of regulatory requirements and processes. &nbsp; · Undertake additional ad-hoc tasks and projects as assigned by the Regulatory Affairs team to support departmental objectives and business needs. &nbsp; Qualifications: · Currently enrolled in a Bachelor's or Master's degree program in a relevant field such as Regulatory Affairs, Life Sciences, Pharmacy, Biology, or a related discipline. · Strong attention to detail and organizational skills. · Excellent analytical, written and verbal communication skills. · Ability to work independently and collaboratively in a team environment. · Proficiency in Microsoft Office suite (Word, Excel, PowerPoint). &nbsp; Preferred Qualifications (but not required): · Prior experience, course work, and/or certification in regulatory affairs. · Familiarity with medical terminology. · Basic understanding of cellular and molecular biology underlying gene therapy. · Familiarity with document management systems and spreadsheets (Smartsheet, Excel, etc.). &nbsp; U.S. Pay Range $23-$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Regulatory Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Job Title Director, Patient Advocacy &amp; Medical Affairs Reports To VP of Clinical Development Position Summary Prime Medicine is seeking an Associate Director or Director, Patient Advocacy &amp; Medical Affairs to lead patient-focused engagement across our rare disease gene-editing programs. This role is central to ensuring that the patient voice meaningfully informs development strategy, clinical trial design, and external engagement, while also supporting Medical Affairs activities with credible, patient-grounded insights. The successful candidate will build trusted relationships with patient communities, advocacy organizations, caregivers, and clinicians, and will work cross-functionally with Clinical Development, Medical Affairs, Regulatory, and Communications teams. This is a highly collaborative role for a leader who combines deep empathy and credibility with patients and a strong understanding of medical, scientific, and regulatory contexts. Key Responsibilities Patient Advocacy Leadership Serve as the primary internal advocate for patients and caregivers across rare disease programs. Build and maintain long-term, trust-based relationships with: Patient advocacy organizations Patient leaders and caregivers Community groups and foundations Ensure patient perspectives are integrated into: Clinical trial design and execution Endpoint selection and feasibility considerations Study materials and participant experience Lead patient advisory boards, listening sessions, and community engagements in a compliant and transparent manner, including oversight of sponsorship activities and events as well as inquiry tracking. Partner with cross-functional teams to incorporate patient insights into development decisions. Medical Affairs Partnership &amp; Support Collaborate closely with internal teams to: Support external scientific engagement with healthcare professionals and key opinion leaders Ensure patient-focused insights inform medical strategy and external education Contribute to the development and review of: Medical and scientific communication materials Patient-facing educational resources Advocacy-appropriate disease and treatment education content Support congress planning, advisory boards and patient panels, and non-promotional medical education activities with a patient-centered lens. Clinical Development &amp; Cross-Functional Collaboration Partner with Clinical Development and Clinical Operations to: Provide patient-centric input on protocol design, inclusion/exclusion criteria, and visit burden Improve trial awareness, access, and participant experience Support regulatory interactions and briefing materials by articulating patient needs and unmet burden. Collaborate with Regulatory and Legal teams to ensure advocacy activities are compliant and aligned with company values. Strategy, Insights &amp; Impact Monitor and synthesize patient community insights, unmet needs, and emerging trends across relevant rare diseases. Translate patient insights into actionable recommendations for leadership and program teams. Help shape long-term patient engagement strategy as programs advance through development. Represent the company externally as a credible, compassionate, and scientifically grounded partner to the patient community. Qualifications Required Bachelor’s degree required; advanced degree (Master’s, PhD, PharmD, MD, MPH) preferred. 15+ years of experience in patient advocacy, medical affairs, rare disease engagement, or related roles within biotech, pharma, federal or nonprofit settings. Demonstrated experience working directly with patient advocacy organizations and patient communities. Strong understanding of clinical development and medical affairs in rare diseases. Excellent communication skills, with the ability to translate complex science into patient-appropriate language. Proven ability to collaborate cross-functionally in a fast-paced, mission-driven environment. Preferred Experience in gene therapy, gene editing, or other advanced modalities. Industry experience supporting early-stage clinical programs. Familiarity with regulatory and compliance considerations for patient engagement. Background in rare genetic diseases. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$213,000&mdash;$261,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Director, Patient Advocacy & Medical Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking a motivated and skilled Senior Scientist to join the Nonclinical Development group, contributing to the DMPK function in support of exploratory and IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, DMPK/Bioanalytical Sciences, this individual will independently analyze and interpret datasets from in vivo studies, contribute to nonclinical regulatory documents, and work cross-functionally with pharmacology, translational biology and external CROs, to ensure high-quality DMPK data packages are delivered to support program timelines. The ideal candidate has a strong foundation in in vivo pharmacokinetics for RNA therapeutics and/or LNP-based delivery systems, thrives in a fast-paced and matrixed organization, and possesses the flexibility and positive attitude needed to make meaningful contributions to the Nonclinical Development team. Primary Responsibilities Analyze and interpret PK study data from exploratory and IND-enabling in vivo Perform non-compartmental analysis (NCA) using Phoenix WinNonlin to derive key PK parameters (Cmax, AUC, T½, Vd, CL). Leverage expertise in DMPK to provide recommendations for in vivo study designs in collaboration with pharmacology and key stakeholders. Perform bioanalytical assay development (30%) and collaborate with bioanalytical scientists to trouble-shoot challenges during method development to ensure quantitative methods for key analytes (LNP lipid components, mRNA, pegRNA, PD biomarkers) meet regulatory expectations and data quality standards.. Contribute to nonclinical regulatory documents including pharmacokinetics summaries and nonclinical study reports under the guidance of senior stakeholders in Nonclinical Development. Maintain thorough records in the electronic laboratory notebook (ELN); prepare clear data summaries, presentations, and technical memos for program team and governance meetings. &nbsp; Qualifications Minimum Qualifications D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biochemistry, or a related discipline. 6+ years of cumulative experience. Industry experience (biotech or pharmaceutical) with direct responsibility for in vivo DMPK study design, execution, and interpretation is required; postdoctoral training in a DMPK or translational pharmacology setting is strongly preferred Demonstrated experience with in vivo PK studies in preclinical models and proficiency in NCA using Phoenix WinNonlin or equivalent software. Familiarity with regulatory expectations for nonclinical DMPK assessments and bioanalytical assay development. Demonstrated ability to coordinate with external CROs, including scientific guidance, protocol development, and data review.. Strong written and verbal communication skills; ability to present complex DMPK data clearly to multidisciplinary audiences. Highly self-motivated, collaborative, and organized, with the ability to manage multiple priorities independently in a fast-paced matrix environment. &nbsp; Preferred Qualifications Familiarity with PK/PD modeling concepts; experience with Phoenix WinNonlin modeling modules a plus. Experience with LNP-based delivery systems and/or RNA therapeutics (mRNA, siRNA, ASO, sgRNA or related modalities). Experience with exploratory DMPK studies, evaluating new delivery vehicles and evaluation of biodistribution using in vivo Familiarity with bioanalytical platforms supporting DMPK studies, including LC-MS/MS, RT-qPCR/ddPCR, ELISA/MSD. Ability and excitement to contribute to the development and success of the Nonclinical Development team. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$145,000&mdash;$177,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Scientist, Drug Metabolism & Pharmacokinetics (DMPK)

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking an enthusiastic, self-motivated Senior Scientist to join the Nonclinical Development group, supporting the nonclinical safety assessment function for IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, Safety Assessment, the successful candidate will support the design, execution, and interpretation of nonclinical safety studies conducted both in-house and at CROs, with an initial focus on liver-targeted therapeutics. This role requires hands-on involvement in assay execution and troubleshooting, as well as active participation in study oversight of work being done at CRO and data analysis. This role requires collaboration within cross-functional teams. The ideal candidate will hold a Ph.D. in toxicology or a related field with 6+ years of pharma/biotech experience in nonclinical safety assessment, or an M.S. in toxicology or a related field with 10+ years of experience in nonclinical safety assessment, the ability to work independently, provide domain expertise and leadership, as well as cross-functionally in a fast-paced, matrixed environment with a positive, flexible attitude. &nbsp;&nbsp; Primary Responsibilities Contribute to nonclinical safety activities as part of cross-functional Discovery and Development project teams, supporting program progression through IND-enabling stages. Design, execute, and troubleshoot nonclinical safety studies, including hands-on laboratory work (~30%) to support assay development, data generation, and issue resolution. Support the execution and oversight of nonclinical safety studies (GLP and non-GLP) at CROs, including active involvement in troubleshooting assay and study-related challenges. Analyze and interpret study data with guidance and contribute to the preparation of study reports and supporting documents for regulatory submissions. Collaborate with Pharmacology, DMPK, and other functions to support exploratory studies (e.g., exploratory toxicology, DMPK, biodistribution, and delivery platform evaluation). Contribute to evaluation of new delivery approaches, Lipid and RNA components, and emerging targets to support pipeline expansion. Assist in identifying potential safety findings and contribute to discussions on data interpretation and next steps. Ensure studies and internal activities are conducted in compliance with regulatory guidelines and internal standards. Preferred Qualifications Ph.D. in toxicology or a related discipline with 6+ years of biopharmaceutical industry experience, or M.S. in toxicology or a related field with 10+ years of relevant biopharmaceutical industry experience supporting drug development in nonclinical safety/toxicology. Experience in large molecule therapeutic development, along with a background in immunology, is desirable. Understanding of toxicology principles, nonclinical safety evaluation, and the drug development process, with some experience interpreting toxicology data and contributing to technical and scientific reports. Demonstrates strong scientific judgment and leadership with the ability to evaluate information, identify potential issues, and propose practical solutions with guidance as needed. Highly organized and detail-oriented with strong attention to accuracy and quality. Strong communication and collaboration skills, with the ability to work effectively across multidisciplinary teams and with external partners. Experience supporting nonclinical studies at CROs is preferred but not required. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$145,000&mdash;$177,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Scientist, Safety Assessment

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.&nbsp; A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.&nbsp; We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.&nbsp; Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives. Position Overview Prime Medicine is seeking a talented and motivated Sr. Manager to join the Analytical Development &amp; QC team within Technology, Development &amp; Operations. This role will focus on Quality Control (QC) related activities for all programs, including management and technical oversight of tech transfer, qualification/validation and release and stability testing carried out at both CDMOs, CTLs and internally at Prime for our prime editing ex vivo cell therapy and in vivo LNP-based drug products. The successful candidate will have deep understanding of method lifecycle management, including method optimization, qualification, validation/verification, transfer, and implementation in a cGMP environment, as well as previous hands-on experience in at least some aspects of the above. This is a role requiring strong cross-functional collaboration with Analytical Development, Quality, Process Development, Formulation, Informatics, and external partners (CTLs/CDMOs).&nbsp; The ideal candidate thrives in a matrixed, fast-paced environment, works effectively with limited supervision, and demonstrates strong technical ownership and execution. Key Responsibilities Design or review analytical procedures and protocols supporting method lifecycle activities, including optimization, qualification, validation, transfer, verification, performance monitoring, bridging, and comparability studies Manage and conduct select release, stability, and in-process testing for drug substances, drug products, and gene-editing components, and carry out data analysis and trending Support and/or manage analytical method transfer to CTLs/CDMOs, providing oversight, troubleshooting, and ensuring technical and timeline objectives are met Manage GMP sample inventory and chain-of-custody documentation Lead, manage and maintain well-designed stability programs and reference standard programs Author and review protocols, reports, SOPs, and analytical sections of regulatory submissions Familiarity with and ability to learn and use new tools for productivity, project management, documentation, tracking scheduling, and data management. Support IQ/OQ/PQ of QC equipment and ensure compliance with 21 CFR Part 11 Maintain GxP-compliant electronic documentation and thorough laboratory records Collaborate with Quality to ensure data integrity, regulatory compliance, and audit readiness Lead or support investigations, deviations, and root-cause analyses Present data and findings to cross-functional teams Prepare technical reports and documents for global regulatory submissions Qualifications Education &amp; Experience BS/MS/PhD in Biochemistry, Molecular biology, Chemistry, Bioengineering, or a related discipline Industry experience: BS: 10+ years MS: 8+ years PhD: 3+ years Technical Expertise Experience with analytical method optimization, tech-transfer, qualification, validation, and verification used for critical components, drug substance and drug product release and stability testing Hands-on experience with analytical methodologies such as: Chromatography-based assays Absorbance-based assays Cell-based assays Compendial assays Molecular-based assays Flow cytometry assays Familiarity with ICH and FDA guidelines for CMC development during clinical stage is required Experience in advanced cell and gene-editing therapeutics development is not mandatory, but highly desirable Experience working with CMOs/CDMOs is required Experience with stability and/or reference standard programs is a plus Knowledge of assays, instrumentation, and facility qualification/validation requirements is desirable Familiarity with regulatory writing Personal Attributes Highly self-motivated with strong project ownership Strong collaborator with internal cross-functional and external partners Adaptable in a dynamic, fast-paced environment Detail-oriented with strong troubleshooting and problem-solving skills Excellent written and verbal communication skills Strong abilities to lead and facilitate technical meetings with CDMO and CTL SMEs Work with purpose and drive meaningful results Ability to innovate and challenge industry status quo Ability to travel for up to 5 - 10% of the time Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$144,000&mdash;$176,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Sr. Manager, QC

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: We are seeking an experienced and motivated Scientist II to join the Cell therapy team within the Process Development department to execute on supporting BLA activities associated with PM359 ex vivo cell therapy program. This role is central to overseeing process validation and clinical manufacturing oversight at our CDMO partner and to provide technical documentation needed for regulatory submissions. This is an exciting opportunity to work at the intersection of cell biology, cell processing, bioengineering, and manufacturing to bring a breakthrough genetic medicine to patients in need and to gain experience with product licensure.&nbsp; This is a hands-on, technical role where the successful candidate will be involved in multiple technical and external manufacturing activities, so excellent organizational abilities, communications and collaboration are critical. The ideal candidate thrives when working in a fast-paced environment, working with purpose, and making an impact for patients. &nbsp;Primary Responsibilities: Apply knowledge in ex vivo cell therapy manufacturing unit operations (i.e., cell isolation, electroporation, culture, formulation, and cryopreservation) to prepare technical reports and documents for BLA. Use knowledge of CPPs, PARs/NORs and QbD applied to process validation. Collaborate with Analytical Development and Quality to document the process control strategy. Serve as Subject Matter Expert (SME) to provide on-site support at the CDMO, oversee process execution, contribute to knowledge transfer and operator training, review batch records, investigate and close process deviations, and analyze manufacturing trends to recommend improvements. Represent Cell Therapy MSAT on cross-functional team meetings; provide technical assessments and risk mitigation strategies.&nbsp; Broaden experience and expertise by supporting other platform technologies associated with PM359 and then provide expertise to other pipeline programs.&nbsp; &nbsp; Qualifications PhD in Bioengineering, Chemical Engineering, Immunology, or related life science field with 3+ years of industry experience; or M.S/BS with 8+/10+ years of directly applicable full-time work experience. Deep hands-on experience in cell therapy manufacturing including cell isolation, gene editing, electroporation, cell culture, formulation, and cryopreservation Experience with automated cell therapy unit operations required (e.g., Rotea, LOVO, CliniMACS); experience with cell therapy analytical methods preferred Proven experience overseeing or working within cGMP manufacturing at a CDMO or internal GMP facility, including experience being the Person-In-Plant during campaigns, batch record creation and review. Proficiency with DoE and statistical methods for process characterization; ability to link process parameters to product quality outcomes Excellent written and verbal communication skills; ability to clearly present technical data to cross-functional audiences. Highly self-motivated, detail-oriented, and able to operate independently with strong ownership mindset. Comfortable in a fast-paced, matrixed biotech environment with evolving priorities. Familiarity with common statistical analysis tools (e.g., JMP, Minitab), project management tools (e.g., Smartsheet), and productivity tools including generative AI (e.g., Claude, ChatGPT). Ability to travel to manufacturing site up to 20% of the time as needed. Preferred Qualifications Experience with late-stage HSC or T cell therapy process development, including PPQ execution and/or BLA CMC authorship; rare-disease program experience is considered a plus Prior experience as a Sponsor-side person-in-plant representative or as a cell therapy CDMO technical representative working with Sponsors. Familiarity with regulatory submission writing and review. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$131,000&mdash;$161,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Scientist II -  Cell Process Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Position Overview: Join a collaborative, agile and dynamic Clinical Development Operations (CDO) team by leading and contributing to transformative clinical programs for patients in rare diseases and beyond. In this position, you will be hands-on in day-to-day study execution, working closely with internal study team members, clinical sites, and external CROs and vendors. This position is ideal for someone who thrives in a fast-paced, evolving environment, is comfortable wearing multiple hats, and is eager to learn more about clinical trial management and execution. This is a hybrid role requiring a combination of in-office presence (Watertown, MA) and remote work, with expectations aligned to team and business needs. &nbsp; Key Responsibilities: · Support the execution of clinical trials from startup through closeout, ensuring adherence to protocol, timelines, and quality standards · Assist with site startup activities, including regulatory document collection, IRB/EC submissions, and site readiness/activation · Support development of study and site-facing materials (e.g., ICFs, recruitment materials, study manuals, CCGs, study tools) and coordinate cross-functional review and approval · Prepare and maintain meeting minutes, action items, and follow-ups for key study team meetings · Maintain study documentation (e.g., sponsor TMF oversight and ISF support) to ensure completeness, quality, and inspection readiness · Oversee CRO/vendor TMF activities, ensuring alignment with sponsor expectations, TMF plans, and filing timelines · Track study progress, enrollment, IRB/EC submissions and queries, and key operational metrics; proactively identify and escalate risks to timelines or deliverables · Serve as a primary point of contact for CRAs and sites to address day-to-day operational questions and issues · Track and monitor key subject visits and study milestones to ensure protocol compliance and data integrity · Support inspection readiness activities, including TMF reviews, audit support, and resolution of findings · Support clinical sample management activities, including coordination of central labs, sample logistics, tracking, and issue resolution · Review clinical data, monitoring reports, and protocol deviations to ensure quality, compliance, and timely issue resolution · Contribute to SOP development, process improvements, and operational best practices within a growing organization &nbsp; Qualifications: · BS/BA/RN Degree in science or a health-related field is preferred · Minimum 2–4 years of clinical research experience; sponsor experience is strongly preferred. · Familiarity with clinical trial operations, ICH-GCP, and regulatory requirements · Experience and understanding of EDC systems, TMF systems, and clinical trial documentation · Familiarity with clinical data review and data management processes, including Data Monitoring Committees · Highly organized with strong attention to detail · Ability to manage multiple priorities with a sense of urgency in a fast-paced environment · Strong communication and relationship-building skills · Resourceful, proactive problem-solver with a “do-what-it-takes” mindset · Comfortable operating in a dynamic environment with evolving processes and priorities · Self-motivated, collaborative, and able to work both independently and cross-functionally · Positive, team-oriented attitude with a passion for advancing innovative therapies for patients · Excitement to contribute to Prime Medicine’s culture! &nbsp; Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$117,000&mdash;$143,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Sr. Clinical Research Coordinator, Clinical Operations

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Summary The Staff Accountant will play a key role in the accounting and financial activities for Prime Medicine.&nbsp; In this crucial role, the Staff Accountant will have exposure to a wide range of business and operational initiatives, accounting and financial reporting activities and ad hoc projects. This role is focused on monthly and quarterly close financial procedures and supports the Procure-to-Pay functions.&nbsp; The candidate will join an evolving finance and accounting team recognized as valued business partners. This position offers exposure to many levels of the organization, providing outstanding opportunities to influence the direction of the business and to grow your career. Position will report directly to Associate Director of Procurement.&nbsp; &nbsp; Key Responsibilities Execute month-end, quarter-end, and year-end close activities in a timely and accurate manner, including preparation and posting of journal entries, account reconciliations, roll forwards and variance analyses Provide internal customer service support for the Procure-to-Pay (P2P) processes and day-to-day activities, ensuring users are properly trained and transactions are recorded accurately Maintain Vendor Master File and act as the primary contact for vendor inquiries regarding payment status and statement reconciliation Lead efforts around accounts payable efficiencies, including driving automation and other process enhancements Manage weekly cash disbursement processes, coordinate payment approvals and payment timing Oversee and manage Concur for employee expense reports from review to reimbursement, ensuring compliance with company policies Manage fixed assets and depreciation ensuring compliance with accounting standards and company policies Support external and internal audits by preparing schedules, reconciliations, and documentation Ensure business transactions continue to be in accordance with generally accepted accounting principles, policies, and SOX controls Assist with special projects and ad-hoc analysis across accounting functions as assigned &nbsp; Education &amp; Experience Bachelor’s degree in finance or accounting (preferred), with 2-3 years of progressive accounting experience with at least 2 years in public accounting or a high-growth tech/life sciences company Strong understanding of U.S. GAAP and willingness to deepen technical accounting knowledge Proficiency in MS Office (especially Excel) and experience with accounting/ERP software &nbsp; Required Skills &amp; Competencies Demonstrated analytical skills to solve complex problems and address a variety of variables in situations with limited standardization Strong organizational skills to effectively balance priorities, handle workload, and complete projects on time Highly organized and diligent, with time management abilities Strong interpersonal skills for effectively communicating with internal &amp; external stakeholders of all levels. Ability to work independently across multiple financial systems and troubleshoot/resolve issues as needed. Self-motivated and capable of working independently Hybrid work position with some in-person attendance required (Cambridge, MA) The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$86,000&mdash;$113,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Staff Accountant

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: &nbsp; Prime Medicine is seeking a skilled legal intern to join our legal team and play a key role in supporting the company’s mission to develop next-generation gene editing therapies. This role will focus on contract review, legal research, and compliance, while gaining exposure to business law and general legal counsel. Responsibilities include drafting, analyzing risk, and supporting attorneys, offering hands-on experience in corporate, intellectual property, and employment law. This position requires close collaboration with internal stakeholders and external partners to ensure effective legal support that advances Prime Medicine’s strategic objectives. Key Responsibilities: Assist in reviewing, drafting, and negotiating commercial agreements, sales, and vendor contracts. Conduct legal research, draft legal memoranda, and prepare corporate documents. Support the legal team in ensuring compliance with regulations and developing internal company policies. Organize legal files, assist with corporate record-keeping, and help with intellectual property matters. Participate in meetings with internal business units, outside counsel, and stakeholders. Qualifications: Current enrollment in an accredited law school (JD candidate). Strong legal research, writing, and communication skills. High level of professionalism, discretion, and ability to handle confidential information. Basic understanding of corporate law, commercial transactions, or compliance. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$26&mdash;$26 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Legal Intern

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Location: Cambridge, MA Engagement: Internship (Full Time, Summer) Level: Undergraduate (Junior or Senior) About Prime Medicine Prime Medicine is a genetic medicines company developing a new class of one-time curative therapies using prime editing, a precise gene editing technology capable of correcting virtually any type of mutation without cutting both strands of DNA. Our pipeline spans multiple therapeutic areas, and our CMC organization plays a central role in translating scientific breakthroughs into medicines that meet the rigorous standards required for clinical development. Role Summary This internship places you inside Prime Medicine's CMC function at a moment when our programs are advancing toward and through clinical development. You will contribute real statistical support across analytical method validation, process characterization, stability analysis, and specification setting to provide the quantitative backbone of any CMC package. This is hands-on work. You will analyze real data from real programs, interact with scientists and CMC colleagues to understand the questions behind the numbers, and produce outputs that directly inform development decisions. A strong working knowledge of applied statistics and genuine curiosity about biopharmaceutical development are the two things that matter most. Key Responsibilities Analytical Method Validation Apply statistical methods (including design of experiments, DoE) to support method development, qualification and validation activities, including assessments of accuracy, precision, linearity, range, and robustness. Summarize and interpret data in a manner suitable for inclusion in regulatory-facing documentation. Process Characterization &amp; Development Statistics Support statistical analysis of process development data to identify critical process parameters and understand sources of variability. Contribute to DoE planning and analysis in collaboration with process development scientists. Stability Analysis &amp; Shelf-Life Modeling Analyze stability data using ICH-aligned statistical approaches, including regression modeling and degradation rate estimation. Contribute to the development and maintenance of statistical process control (SPC) techniques for monitoring reference standard and critical reagent performance. Support shelf-life and retest period calculations and help maintain stability tracking tools. Specification Setting &amp; Release Testing Apply statistical methods to support specification setting for drug substance and drug product, including tolerance interval calculations and acceptance criteria justification. Assist in statistical review of release and characterization data across development-stage lots. Documentation &amp; GxP Practices Prepare clear, well-documented statistical analyses suitable for inclusion in technical reports, regulatory submissions, and IND-enabling packages. Work within a GxP-aware environment; gain practical exposure to documentation standards and data integrity principles relevant to early-phase pharmaceutical development. Qualifications Required Enrollment in a BS program in Statistics, Biostatistics, Mathematics, Chemical Engineering, or a related quantitative discipline; junior or senior standing preferred. Solid foundation in applied statistics, including regression, hypothesis testing, variance analysis, and tolerance or confidence intervals. Proficiency in at least one statistical computing environment (R, Python, JMP, or Minitab). Ability to communicate quantitative results clearly, both in writing and in conversation with scientific collaborators. Preferred Coursework or project experience in experimental design (DOE) or statistical process control. Familiarity with ICH guidelines relevant to CMC statistics (e.g., Q2(R2), Q8, Q1E). Prior lab, co-op, or research experience in a pharmaceutical, biotech, or academic drug development setting. Exposure to GxP environments or data integrity principles, even in an academic or co-op context. Why This Internship Most statistics internships keep interns at arm's length from the decisions that matter. This one does not. Prime Medicine is a focused company building programs from the ground up, which means the work you do this summer will be visible, consequential, and connected to people who can explain why it matters. You will leave with a clear understanding of how statistics functions inside a GxP-facing CMC organization, and with work product you can speak to directly.Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

CMC Statistician Intern

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Summary Reporting to the Associate Director, Procurement, the Accounting Operations Associate will be responsible for managing the day-to-day procurement and accounts payable activities and providing general end user support across all Procure-to-Pay (P2P) functions Key Responsibilities Provide internal customer service support for the P2P processes and day-to-day activities, ensuring users are properly trained and transactions are recorded accurately. Maintain Vendor Master File and act as the primary contact for vendor inquiries regarding payment status and statement reconciliation. Manage Accounts Payable mailbox to triage incoming mail appropriately and address external &amp; internal inquiries as needed. Lead efforts around accounts payable efficiencies, including driving automation through AI adoption and other process enhancements. Facilitate &amp; execute the preparation of weekly payment run, working with accounting team to troubleshoot &amp; resolve any issues. Oversee and manage Concur for employee expense reports from review to reimbursement, ensuring compliance with company policies. Support quarterly and annual financial audit processes by preparing the requested support and documentation. Assist with special projects and ad-hoc analysis across accounting functions as assigned. &nbsp; Required Skills &amp; Competencies Bachelor’s degree in finance or accounting, with 1-3 years of Procurement or Accounting experience (preferred). Proficiency in MS Office (especially Excel) and experience with accounting/ERP software Demonstrated analytical skills to solve complex problems and address a variety of variables in situations with limited standardization. Strong organizational skills to effectively balance priorities, handle workload, and complete projects on time. Organized and diligent, with time management abilities. Strong interpersonal skills for effectively communicating with internal &amp; external stakeholders of all levels. Ability to work independently across multiple financial systems and troubleshoot/resolve issues as needed. Self-motivated and capable of working independently. Hybrid work position with some in-person attendance required (Cambridge, MA). The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$77,000&mdash;$94,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Fall 2025 Co-op: Medical Writing & Clinical Development

Your career is worth investing in.

Get unlimited referrals with Premium.