Co-op: In-Process Analytics

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies.

Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.   Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung.

Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Fall 2026 Co-op: In-Process Analytics Co-op Assignment Overview Prime Medicine is seeking a Fall 2026 co-op to join our Chemistry team, with a focus on in-process analytics and purification of large RNA molecules. The successful candidate will engage in hands-on laboratory work, including UV absorbance measurements using NanoDrop, purification support, sample analysis by UPLC and mass spectrometry (MS), and endotoxin testing of synthetic guide RNA.

Through this experience, the co-op will develop proficiency in oligonucleotide characterization, gain exposure to a broad range of in-process analytical techniques, contribute to data generation and documentation, and present findings at weekly team meetings. We welcome curious, collaborative problem solvers who are passionate about advancing gene-editing technologies to improve human health.

Primary Responsibilities Support the characterization and purification of Prime's long guide RNA (gRNA) using a suite of laboratory techniques, including ÄKTA purifier, UPLC, LC-MS, NanoDrop, and endotoxin assays Integrate chromatograms for gRNA crude, fraction, and final samples in accordance with Prime's SOPs to quantify full-length product purity, and tabulate results in the team's electronic lab notebook Learn and contribute to mass analysis of gRNA to identify the molecular weight of the full-length product and related impurities Assist senior scientists with buffer preparation, instrument maintenance, and the development of updated analytical methods to expand in-process analytical capacity Manage inventory of critical reagents for buffer preparation in support of purification and analytics operations Coordinate with scientists to maintain inventory records for final released materials Required Qualifications Enrolled in a B.S. or M.S. program in Chemistry, Biochemistry, or a related field; basic knowledge of organic chemistry preferred Prior completion of general chemistry coursework and associated laboratory courses Strong written and oral communication skills, with excellent organizational ability and capacity to work both independently and collaboratively Enthusiasm for learning and contributing across multiple aspects of a research program Preferred Qualifications Prior internship or co-op experience in a relevant setting Completion of analytical chemistry lecture and laboratory courses Hands-on experience in a chemistry laboratory, with familiarity with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure What We Offer A cutting-edge, mentorship-driven team with strong networking opportunities Full reimbursement for monthly commuting costs, including MBTA, Commuter Rail, and Bluebikes Access to regular seminars featuring industry experts Full participation in company-wide activities, including learning and development programming, social events, and more   Please note: We are currently only considering candidates based in the greater Boston/Cambridge area.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range$23—$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Prime Medicine is a biotechnology company focused on developing innovative RNA-based therapeutics to treat genetic diseases. The company's cutting-edge research and technology aim to revolutionize the field of medicine by providing personalized treatments for patients with rare and common genetic disorders. With a dedicated team of scientists and experts, Prime Medicine is committed to advancing the future of healthcare through its groundbreaking approach to gene therapy.