Director, US Commercial Business Operations

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease.

At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities.  Learn more https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.  Role Summary:  The Director, US Commercial Business Operations is a critical role within the commercial organization, driving strategic initiatives and operational excellence to fuel business growth.

Reporting to the Head of US Commercial Operations, this individual is a highly visible commercial leader responsible for building foundational capabilities from the ground up, including operational infrastructure, data strategy, management, and governance; commercial effectiveness program development and execution; and sales enablement.

This role requires strong cross‑functional collaboration across commercial stakeholders in marketing, market access, patient services, finance, IT, and US Commercial leadership to ensure launch readiness and sustained execution. The Director, US Commercial Business Operations serves as a champion of innovation and operational efficiency, streamlining processes and enhancing collaboration with a patient‑first mindset.

This is an individual contributor role requiring strong communication, self‑initiative, and consultative engagement skills.  This role is based in Waltham, MA Primary Responsibilities Include: Operational Excellence and Business Analytics Establish scalable processes for forecasting, demand and sales planning, and performance tracking to ensure operational efficiency.

Manage Veeva, BI tools, and other commercial technology systems to identify market trends, optimize resource allocation, and make data driven-informed decisions. In collaboration with Trade and Distribution lead and finance, create channel analytics to inform forecast demand. Collaborate with marketing operations for Medical/Legal Review Process logistics Partner with marketing operations on National, regional, and local meeting management.

Lead automation of BI reporting for HQ, executive leadership and field in collaboration with IT commercial business partner. Embed AI tools and capabilities into key processes and workflows to improve efficiency, decision-making, and business outcomes. Scalable process for alignments, targeting, and Veeva call cycle planning.

Lead for market access analytics and developing reports through requirement gathering with HUB, SP, SIP and data aggregator. Data Strategy, Management and Governance Implement and refine data strategy as needed. Oversee all data channels for US market, ensure quality, and set up processes to identify data issues Lead SP and data aggregator data integrity meeting process, setting weekly cross-functional team engagements.

Ensure data quality and compliance with security and regulatory standards. Lead data processes and foster collaboration to align organizational goals while driving continuous improvement. Commercial Effectiveness and Execution-Field Enablement Lead field force programs and services, circle of excellence program development, award trip, and administration.

Fleet program development and management. Optimize field enablement tools and materials for maximum field productivity. Education and Skills Requirements Bachelor’s degree and 10+ years of experience in biotech/pharma/life sciences in field sales, sales leadership, commercial business operations or strategy. Proven track record of success in launching rare disease neuromuscular, neurodegenerative or neurodevelopmental therapies.

Strong leadership experience, managing vendors, and scaling commercial infrastructure. Strategic thinker with strong business acumen and results-oriented mindset Proficiency with commercial technology and software platforms, and data (CRM, BI tools, Snowflake, Boomi, SP & SIP and HUB data) Excellent communication skills and problem-solving skills.

Strong writing and verbal communication skills, including ability to present to senior management. #LI-OnsiteMA Pay Range$196,000—$240,000 USD  The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Dyne Therapeutics is a biotechnology company dedicated to advancing life-changing therapies for patients with serious muscle diseases. Leveraging its expertise in muscle biology, nucleic acid delivery, and gene therapy, Dyne is at the forefront of developing innovative treatments to address unmet medical needs and improve the lives of individuals affected by muscle disorders.