Amylyx Pharmaceuticals is a biopharmaceutical company dedicated to developing innovative therapies for neurodegenerative diseases. With a focus on amyotrophic lateral sclerosis (ALS) and other central nervous system disorders, Amylyx is committed to advancing treatments that address significant unmet medical needs.

Executive Assistant to the Chief Human Resources Officer

Manager, Financial Reporting and Technical Accounting

Senior Vice President, Clinical Development

Medical Director - Clinical Development

Senior Medical Director, Clinical Development

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is seeking an experienced and independently motivated scientist to serve as a subject matter expert supporting outsourced bioanalytical strategy, operations, and vendor management. This dynamic position will lead the design, development, and implementation of bioanalytical assays (LCMS, ELISA, qPCR, immunogenicity, cell-based biomarker, in vitro biomarker, etc.) to advance the company’s drug class agnostic preclinical and clinical pipeline. The qualified applicant will contribute to multiple drug programs, serve as a bioanalytical subject matter expert, contribute to study designs, present data and workplans in cross functional meetings, work collaboratively with nonclinical toxicologists and clinical pharmacologists, and manage/operationalize external bioanalytical vendor relationships. The role is open to on-site or hybrid work at our Cambridge, MA office or fully remote within the continental United States. RESPONSIBILITIES Working in collaboration with line management, nonclinical toxicologists and clinical pharmacologists, lead bioanalytical and biomarker method selection and outsourced MD/MQ/MV/SA to support preclinical, nonclinical, and clinical trials with adherence to established program timelines, and with regulatory rigor commensurate with drug program development phase. Select vendors and/or work within pre-established vendor relationships to manage outsourced bioanalytical and biomarker projects. Identify, propose, and develop new solutions to bioanalytical needs. Oversee outsourced bioanalytical and biomarker methods, and ensure methods are developed and qualified/validated following FDA and ICH guidelines. Review and lead bioanalytical MD/MV reports and data summaries. Work in collaboration with nonclinical toxicologists, clinical pharmacologists, and biostatisticians to review sample analysis reports and data summaries. Serve as a bioanalytical leader and subject matter expert in cross functional preclinical and clinical drug program teams to communicate bioanalytical and biomarker science, strategy, risks and timelines. Drive PK, PD, and immunogenicity testing strategy to ensure vendors complete appropriate qualification or validation work to execute on bioanalytical plan(s) on time and with appropriate quality standards. Demonstrated technical abilities with a flexible approach and strong ability to roll-up-your sleeves to get the job done under tight timelines and changing scope. Participate in planning, reviewing and authoring of regulatory and clinical documents, abstracts, posters, protocols, and publications. Identify and resolve root causes of bioanalytical method issues to minimize study impact. Experience with CAPA is preferred. Manage critical reagent life-cycle across program timelines. Prepare and organize data for cross-functional presentation. Communicate strategy and results in written and oral reports to various levels of management. Communicate research efforts to executive team members, collaborators, and/or at scientific meetings. Provide bioanalytical subject matter expertise to diligence on external assets and potential in-licensing opportunities Excellent communication and collaboration skills and ability to work with cross-functional scientists and non-scientists. Ability to convey ideas and opinions clearly, concisely, and with a smile. Occasional travel required for bioanalytical collaboration, conferences and vendor oversight/audit. Travel to the Cambridge, MA office at least 3 times annually. REQUIRED QUALIFICATIONS Ph.D. in biology, chemistry or a related field with at least 5 years, or MS with at least 7 years, of relevant scientific and technical experience in pharma/biotech/CRO environment. At least 2 years’ experience in biotech is non-negotiable. Demonstrated experience developing and leading bioanalysis projects in support of preclinical lead nomination and IND-enabling, and clinical phase 1-3 for LCMS, ELISA, RT-qPCR, ADA, cell-based Nab, biomarker assays. Demonstrated previous bioanalytical method technical expertise in small molecule, anti-sense oligonucleotides, peptides, biologics and their requisite guidance documents. Expert level technical knowledge is preferred in at least 3 of the 4, with willingness and ability to quickly learn and adapt to new technologies. Knowledge of preclinical and clinical drug development regulations with expert-level knowledge of the M10 BMV. Strong knowledge and experience with application of bioanalytical assay development, qualification/validation and sample analysis as it pertains to preclinical and clinical drug development.&nbsp; Demonstrated experience with bioanalytical method documentation to support preclinical in vivo and clinical sample analysis. Experience working in a regulated (GxP) environment preferred but not required.&nbsp; Strong interpersonal skills as well as excellent communication and presentation abilities. Ability to function in a biotech team environment by effectively collaborating within and across departments. Previous experience contributing to regulatory documents and interacting with health authorities. We are seeking an applicant who thrives in a fast-paced, team-oriented environment, and who is willing to travel up to 20% for vendor site-visits per business needs. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Bioanalytical and Translational Science

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is seeking an experienced and motivated Director of Biostatistics. In this role you will liaise with various internal and external stakeholders (e.g. Clinical Development, Regulatory, Pharmacovigilance, Translational Sciences, Programming and Data Management, CROs) for the implementation of a clinical development program, regulatory submissions and post-submission strategies/preparation/defense. RESPONSIBILITIES Provide strategic leadership of statistical approaches on an assigned therapeutic area or a program, shaping clinical development plans from early design through regulatory submission, and serving as a statistical thought partner to cross-functional leaders and external stakeholders. Design and oversee implementation of robust, innovative trial designs that maximize probability of clinical and regulatory success, balancing scientific rigor with operational feasibility, while anticipating and proactively addressing potential regulatory challenges. Mentor, coach, and develop statisticians at varying levels of experience by providing technical guidance, fostering professional growth, and instilling best practices in statistical methods, data integrity, and regulatory compliance. Synthesize and present statistical insights by preparing data packages and cross-functional presentations, effectively communicating strategies, assumptions, and implications to leadership, regulatory bodies, and scientific audiences. Partner closely across functions to ensure alignment, collaboration, and timely execution of statistical deliverables that enable high-quality program success. Engage in occasional travel (Cambridge, MA and other locations) for collaboration and conferences, typically at least three times annually. REQUIRED QUALIFICATIONS PhD in Statistics/Biostatistics, Mathematics, or related quantitative fields with a minimum of 10 years, or MSc with a minimum of 14 years of experience with clinical trials including late-phase studies. Proficiency in scientific computing/programming (SAS or R) and implementation of advanced statistical analyses and simulations, deep knowledge of CDISC standards. Proficiency in the design of clinical trials Phases I – III, in applying knowledge of general and cutting edge statistical / clinical trials methodologies to solve complex statistical problems in the clinical development programs and to ensure alignment with regulatory agencies and industry standards. Demonstrate skills in the analysis and reporting of clinical trials; experience with integrated summaries of safety and efficacy (ISS and ISE). Prior experience in interactions with regulatory and health authorities considered a plus. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Biostatistics

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is seeking a Senior Medical Director, Clinical Development to be the lead for a late-stage, pivotal program that has the potential to expand to additional programs with the same molecule.&nbsp; This program may be the first of several for this molecule given the mechanism of action of the drug. Opportunities to lead additional development programs with other assets also may arise, together with leading a small team of clinical scientists and physicians. Reporting to the Senior VP of Clinical Development, you will be responsible for medical monitoring for assigned clinical trials, the development and implementation of the Clinical Development Plan for the assigned assets, including clinical study design and execution, as well as interpretation of study data. The successful candidate will interact within a multi-disciplinary, matrix work group including research, ensuring that clinical and scientific issues are appropriately considered in the development and execution of individual clinical studies and overall clinical development plans. You will be involved in potential translational activities, operationalizing studies, monitoring data in real time to ensure the integrity of the study, proactively identifying issues in the conduct of trials, and in medical review and analysis of data for the purposes of both data cleaning and interpretation for regulatory documents and publications. In this role you will interact with multiple functions and management within Amylyx, and with external stakeholders including the global medical expert community, global regulatory authorities, alliance partners and vendors. THE RESPONSIBILITIES Provides medical monitoring to assigned clinical trials in the arenas of serious endocrine conditions, neurogenerative and/or rare disease Provides clinical development leadership for programs that integrate extensive knowledge in clinical science with inputs from the global medical and patient communities. Works closely with Medical Directors, Pharmacology, Drug Discovery, external experts, and investigators to accumulate scientific and medical knowledge necessary to support clinical development plans. Integrates scientific rationale, regulatory requirements, product development plan, and value to patients and shareholders to build a solid Clinical Development Plan (CDP). Accountable for production of highest quality program related documents, including protocols, IBs, clinical study reports, briefing documents and drug labels. Develops and maintains relationships with program counterparts in Research, Regulatory Affairs, Clinical Operations, Statistics and Contract Research Organizations (CROs). Acts as the primary Clinical Development interface with internal stake holders as well as external subject matter experts and alliance partners for the assigned programs. Contributes to specific Business Development activities and various organizational initiatives in Clinical Development. REQUIRED QUALIFICATIONS MD required Experience with late-stage clinical development and drug development in rare diseases strongly preferred 4+ years of experience in leading clinical development programs in the biotechnology/pharmaceutical industry with a proven record of achievements. Ability to think critically and demonstrate troubleshooting and problem-solving skills. Demonstrated leadership and team building skills as well as the ability to perform effectively in a multi-disciplinary environment. Ability to lead directly and by influence, including strong interpersonal, problem solving, conflict resolution and analytical skills in a matrix environment. Excellent communication skills (oral and written) and organizational skills. Ability to travel internationally and domestically WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp; &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is seeking a Senior Director, US Field Medical, who will recruit, train, and manage a team of Field Medical professionals (MSLs) to execute the company's medical strategy with an initial &nbsp;focus on the lead program, Avexitide in post-bariatric hypoglycemia (PBH), while also overseeing field medical strategy across Amylyx’s broader and expanding therapeutic portfolio. This leadership role involves driving the vision for field-based activities, overseeing medical and scientific engagement with key opinion leaders (KOLs), and leveraging insights to inform business and clinical strategy. The Senior Director acts as a critical link between the field team and cross-functional leadership, including Medical Affairs, Commercial, Clinical Development, and Research and Development (R&amp;D). RESPONSIBILITIES Strategic Leadership: Develop and execute the national field medical strategy in alignment with the broader Medical Affairs and company objectives. Define the vision, set strategic goals, design and report KPIs, and ensure tactical execution across the field team. Team Management and Development: Recruit, hire, train, and manage a high-performing field medical team. Foster a culture of scientific excellence, accountability, and continuous learning. Provide mentorship, coaching, and career development opportunities to team members. Medical and Scientific Engagement: Oversee the team's scientific exchange activities with external stakeholders, including national and regional KOLs, healthcare providers (HCPs), and professional medical societies. Ensure the team delivers timely, impactful data and communicates scientific information accurately and compliantly. Cross-Functional Collaboration and Leadership: Partner closely with internal departments—including Medical Affairs, Commercial, Clinical Development, R&amp;D, Market Access, and Regulatory—to ensure alignment and support for product launches, payer engagements, clinical trial activities, and other strategic initiatives. Insight Generation: Establish a process for gathering, summarizing, and disseminating field-based medical insights to internal stakeholders to inform strategic decision-making and identify educational gaps. Compliance and Operations: Ensure all field medical activities adhere to company Standard Operating Procedures (SOPs) and regulatory and compliance guidelines. Oversee operational aspects, including budget management, performance tracking, and the effective use of customer relationship management (CRM) systems. REQUIRED QUALIFICATIONS An advanced degree is required, such as a PharmD, MD, PhD, or equivalent. A minimum of 10 years of relevant experience in the pharmaceutical or biotech industry, with at least 5 years in a field medical leadership role with people management responsibilities. Strong understanding of drug development, clinical trial methodology, and industry regulations and guidelines governing field medical activities, including the PhRMA code and FDA promotional guidelines. Experience/expertise in endocrinology/obesity medicine strongly preferred. Proven track record of leading and developing high-performing teams. Must possess strong strategic, organizational, communication, and interpersonal skills. Requires significant travel, often up to 60% domestically, to attend scientific conferences, internal meetings, and field visits. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Field Medical Affairs

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is looking for a Director, Drug Substance, to join our CMC and External Manufacturing team. In this role you will be the technical development drug substance owner for Amylyx’s Phase III synthetic peptide, Avexitide, and pre-clinical antisense oligonucleotide, AMX-0114.&nbsp;This position will work directly with external CDMOs to develop, scale-up, and validate drug substance processes. Initially this role will be an individual contributor, however, may evolve into a functional head. In this highly collaborative and visible role, you will be a key member of asset CMC teams. This role reports to the Senior Vice President, Global CMC and External Manufacturing. RESPONSIBILITIES Lead CMC drug substance phase appropriate development activities to ensure Module 3 content that supports global clinical filings and registration plans Serve as the technical SME and process owner for drug substance. Working with contract manufacturing organizations, develop scalable and robust manufacturing processes for oligonucleotides and peptide products Author IND and NDA Module 3, Master Batch Records, Validation Plans and Reports Ensure robust regulatory plans for all changes while minimizing risk to product supply Foster effective teamwork and drive project execution. Proactively track critical path activities, anticipate risks, create contingency plans and decision-making exercises in collaboration with project teams. Update project timelines and budgets, communicate progress, and maintain the CMC program plan Regularly interacts with functional areas including Regulatory, Quality, Supply Chain, Commercial, Medical, Clinical, and non-Clinical development Manage external resources including Consultants and Contractors, as needed to deliver projects Travel to global manufacturing sites to support operations and validation activitie REQUIRED QUALIFICATIONS Bachelor’s degree in organic chemistry, chemical engineering, or related field. MS or PhD preferred A solid understanding of small molecule, RNA, and amino acid chemistries At least 15 years of experience in API development from early through late-phase. Prior process validation experience preferred Experience developing oligonucleotide and/or synthetic peptide processes including impurity control strategies Experience leading global, cross-functional, high performing teams. Prior experience leading or serving on a CMC team preferred Advanced knowledge of cGMP/GLP regulations, ICH, FDA CMC Guidance Documents A strong track record of successful global CMC submissions and approvals Must be able to function independently and influence appropriate stakeholders and recommend scientifically rigorous, phase appropriate, risk-management based solutions to complex technical challenges Experience working with contract manufacturing organizations Excellent communication and teamwork skills Ability to travel internationally up to 10% WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Drug Substance

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY The Senior IT Leader for Commercial and Medical Affairs will be responsible for driving the strategic direction, implementation, and support of technology solutions that enable Amylyx’s Commercial and Medical functions. This role ensures the delivery of scalable, robust, and compliant applications aligned with evolving business needs. You will lead the IT Commercial Business Partner team, collaborating closely with cross-functional stakeholders—including Supply Chain, Finance, and HR—to ensure technology initiatives enhance operational efficiency and support commercial success RESPONSIBILITIES Build strong partnerships across business and technical teams to foster collaboration and effective project execution. Lead the implementation and support of Commercial and Medical business-facing applications, ensuring alignment with strategic priorities. Serve as the primary IT contact for audit and compliance matters related to Commercial and Medical systems, ensuring adherence to regulatory and internal controls. Establish and maintain IT processes and standards for application support within the Commercial and Medical domains. Oversee application enhancements and support activities in alignment with product launch and business objectives. Act as a functional and technical advisor to define, estimate, and propose solutions for business opportunities. Contribute to annual budgeting and planning for Commercial and Medical systems. Administer CRM platforms (e.g., Salesforce, Veeva) for Commercial and Medical Affairs teams. Manage vendor relationships, including assessments and contract negotiations. Coordinate issue resolution with internal teams and external service providers. Maintain the integration roadmap for Commercial and Medical applications (e.g., Commercial Data Environment, HUB, Aggregate Spend, Master Data Management). Lead RFP processes, evaluate proposals, develop ROI analyses, and ensure proper documentation for IT initiatives. Ensure compliance with regulatory requirements, including FDA computer systems assurance, SOX, and GDPR. REQUIRED QUALIFICATIONS Bachelor’s degree in Computer Science or related field. Minimum 10 years of progressive IT experience, including project and team management. 5+ years of experience with CRM and customer engagement platforms (e.g., Salesforce.com, Veeva). Strong understanding of service delivery and application lifecycle management. Familiarity with data privacy regulations and their application to business operations. Proven ability to lead cross-functional teams and manage external service providers. Experience with enterprise systems and software vendor selection. Excellent communication, analytical, and problem-solving skills. Ability to prioritize tasks and make sound decisions under pressure. Demonstrated success in managing IT projects within controlled change management frameworks. Strong customer service orientation and interpersonal skills. Self-motivated with high attention to detail. PREFERRED REQUIREMENTS Experience in Life Sciences, particularly within high-growth pharmaceutical or biotech environments. Experience in Commercial, Marketing and/or Medical Operations within Life Sciences. Strong customer service orientation and interpersonal skills. Self-motivated with high attention to detail. Proficiency in managing SaaS-based application implementations. Strong analytical skills with the ability to translate business needs into technical requirements. Experience with commercial applications and data warehousing. Skilled in documenting and analyzing business requirements and functional specifications. Effective facilitator of team collaboration and group sessions. WORK LOCATION AND CONDITIONS This position is hybrid – we would like someone in the New England area who can come into the office on average 2 times per week – with some flexibility. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, IT Commercial Applications

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY We are seeking an experienced Head of the Market Access Field Team to build and lead a payer and strategic account director field team for a new product launch. This team will be responsible for engaging U.S. payers and health systems to secure coverage and access to treatment for people living with a rare, serious, condition. This is a unique opportunity to shape market access strategies and programs, and to be part of a new commercial team build-out.&nbsp; RESPONSIBILITIES Serve as a key contributor to launch planning and execution, with a focus on access and reimbursement readiness.&nbsp;&nbsp; Build a high performing, strategic and collaborative account team. Design team structure including roles, target accounts, operating practices and incentives. Recruit, onboard, and develop the team through a successful launch.&nbsp; Lead and enable account teams to establish effective relationships at target public and private payers, PBMs and health system customers.&nbsp;&nbsp; Oversee and participate in customer payer PIE (Pre-approval Information Exchange) and clinical presentations, with the goal of securing favorable formulary access and coverage decisions.&nbsp;&nbsp; Partner with commercial leaders to implement solutions that quickly identify, escalate and resolve patient access issues during launch.&nbsp;&nbsp; Identify coverage and access opportunities and drive cross functional pull through efforts.&nbsp;&nbsp; Represent the market access strategy and payer voice with internal stakeholders as business decisions are made in a fast-paced environment.&nbsp;&nbsp; Foster a culture of trust, integrity and teamwork across all commercial functions. Hold team accountable to do the same.&nbsp;&nbsp; REQUIRED QUALIFICATIONS Bachelor’s degree required; advanced degree (MBA, MPH, PharmD) preferred.&nbsp; 10+ years of experience in Market Access. Must have experience leading a US payer field team at the national level, preferably in launch environments.&nbsp; Proven success in securing access for therapies in rare/orphan diseases is strongly preferred.&nbsp; Ability to inspire trust and drive alignment across cross-functional teams.&nbsp; Deep understanding of U.S. payer landscape, reimbursement pathways (including Medicare, Medicaid, and commercial), and policy environment.&nbsp; Ability to understand and present clinical disease state and product information.&nbsp;&nbsp; Strong analytical and financial acumen.&nbsp; WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska and Hawaii. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. This role requires up to 50% travel.&nbsp; &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Head, Market Access Field Team

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is seeking a Medical Director, Clinical Development to be the lead for a late-stage, pivotal program that has the potential to expand to additional programs with the same molecule.&nbsp; This program may be the first of several for this molecule given the mechanism of action of the drug. Opportunities to lead additional development programs with other assets also may arise, together with leading a small team of clinical scientists and physicians. Reporting to the Senior VP of Clinical Development, you will be responsible for medical monitoring for assigned clinical trials, the development and implementation of the Clinical Development Plan for the assigned assets, including clinical study design and execution, as well as interpretation of study data. The successful candidate will interact within a multi-disciplinary, matrix work group including research, ensuring that clinical and scientific issues are appropriately considered in the development and execution of individual clinical studies and overall clinical development plans. You will be involved in potential translational activities, operationalizing studies, monitoring data in real time to ensure the integrity of the study, proactively identifying issues in the conduct of trials, and in medical review and analysis of data for the purposes of both data cleaning and interpretation for regulatory documents and publications. In this role you will interact with multiple functions and management within Amylyx, and with external stakeholders including the global medical expert community, global regulatory authorities, alliance partners and vendors. THE RESPONSIBILITIES Provides medical monitoring to assigned clinical trials in the arenas of serious endocrine conditions. Provides clinical development leadership for programs that integrate extensive knowledge in clinical science and endocrinology, and inputs from the global medical and patient communities. Works closely with Medical Directors, Pharmacology, Drug Discovery, external experts, and investigators to accumulate scientific and medical knowledge necessary to support clinical development plans. Integrates scientific rationale, regulatory requirements, product development plan, and value to patients and shareholders to build a solid Clinical Development Plan (CDP). Accountable for production of highest quality program related documents, including protocols, IBs, clinical study reports, briefing documents and drug labels. Develops and maintains relationships with program counterparts in Research, Regulatory Affairs, Clinical Operations, Statistics and Contract Research Organizations (CROs). Acts as the primary Clinical Development interface with internal stake holders as well as external subject matter experts and alliance partners for the assigned programs. Contributes to specific Business Development activities and various organizational initiatives in Clinical Development. REQUIRED QUALIFICATIONS MD required Experience with late-stage clinical development and drug development in rare diseases strongly preferred 4+ years of experience in leading clinical development programs in the biotechnology/pharmaceutical industry with a proven record of achievements. Ability to think critically and demonstrate troubleshooting and problem-solving skills. Demonstrated leadership and team building skills as well as the ability to perform effectively in a multi-disciplinary environment. Ability to lead directly and by influence, including strong interpersonal, problem solving, conflict resolution and analytical skills in a matrix environment. Excellent communication skills (oral and written) and organizational skills. Ability to travel internationally and domestically WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp; &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Medical Director, Clinical Development

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY The Senior Director of Clinical Pharmacology will provide leadership and support to the clinical pharmacology team and be accountable for the overall strategy for determining the PK, PD, and immunogenicity properties of all drugs and drug candidates in development and, as applicable, through commercialization. As the clinical pharmacology expert within the company, you have experience and expertise in matrixed leadership and team management, and will lead, develop, and educate through cross-functional teams. In addition, there will be opportunities to contribute to diligence assessments. Reporting directly to the SVP, Head of Clinical Development, you will have high visibility at leadership levels, including with the Chief Medical Officer. You can efficiently and effectively synthesize internal and external data to produce a clinical pharmacology strategy. RESPONSIBILITIES Serve as the clinical pharmacologist for the company across all clinical programs, providing strategic and scientific input from preclinical development through Phase 3 trials Lead the Clinical Pharmacology team accountability for the clinical pharmacology strategy for Amylyx' development portfolio from pre-IND through and post approval, including design and implementation of program specific clinical pharmacology studies, data analysis, internal decision points, and external regulatory interactions Integrate clinical pharmacology knowledge with a broad understanding of and collaboration with related disciplines such as clinical, statistics, regulatory, nonclinical ADME, toxicology to support and impact development decisions Ensure appropriate PK, PD and PK/PD data analyses (including population PK, PK/PD modeling and simulation) are conducted for each study/program. Collaborates with toxicologist and preclinical pharmacology scientists to design, analyze, interpret, and report preclinical PK and translational PK/PD studies to support candidate selection and IND filing, including human PK prediction to support starting dose and dose escalation schemes for first-in-human studies Ensure adherence to agreed timelines and budgets to insure prompt and accurate execution of deliverables from clinical pharmacology studies and programs Serves as the clinical Pharmacology expert across study and program teams Develops and implements new clinical pharmacology approaches to processes and clinical studies that impact development programs Contributes to program strategy, study design, protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation Works closely with research and development teams and provides input into assay development, CRO selection and CRO management. Leads method development, method qualification, method validation activities as SME and sponsor monitor, as assigned.&nbsp; Represents nonclinical and clinical pharmacology during meetings and discussions with regulatory authorities Creates or guides nonclinical and clinical pharmacology summary documents Reviews literature and peer-reviewed publications to keep apprised of global regulatory developments in clinical pharmacology; Authors/ reviews manuscripts for submission to peer-reviewed journals REQUIRED QUALIFICATIONS PhD, PharmD, MD, or equivalent training in pharmacokinetics, pharmaceutical sciences, or related disciplines Minimum 10 years of experience within the pharmaceutical and biotechnology industry with 5+ years' direct experience in Clinical Pharmacology Experience in an array of molecules including biologics, small molecules and gene therapy Demonstrated experience in writing, presenting, and discussing clinical pharmacology with regulatory authorities as well as other external and internal stakeholders Strong analytical skills and ability to interpret complex clinical data sets as well as deep understanding of individual patient data coupled with excellent written and verbal communication skills Ability to work in cross-functional teams and manage multiple projects, engaging subject matter experts across functions to drive the execution of programs Strong technical proficiency in PK analysis (NCA and PopPK) Ability to work with an elevated level of integrity, accuracy, and attention to detail, while executing corporate objectives and goals Entrepreneurial, enjoys working in a fast-paced, small-company environment WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Clinical Pharmacology

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY The Senior Director, Health Economics and Outcomes Research (HEOR)/Real World Evidence (RWE) at Amylyx Pharmaceuticals will report to the SVP of Medical Affairs. This position will be an expert and experienced leader, engaging cross functionally to develop and drive HEOR and evidence generation strategies. The Senior Director will play an integral role in developing and communicating the value proposition for Amylyx’ assets, including our lead program in post-bariatric hypoglycemia (PBH).&nbsp; This role will drive development of strategies, methods, and tools to ensure successful market access, adoption, and long-term impact in support of Amylyx’ mission to find solutions for patients with high unmet needs. RESPONSIBILITIES Strategic Leadership Build and lead the HEOR function including the development of integrated HEOR and evidence generation strategies and tactical plans to support Amylyx’s therapeutic programs Lead evidence gap analyses that will inform the HEOR strategic and tactical plans and lead cross-functional data generation and communication planning efforts to support health economic/value proposition and inform understanding of treatment patterns, disease burden, patient-reported outcomes, and unmet needs &nbsp; Evidence Generation &amp; Study Execution Design and execute projects, such as burden of illness, real-world clinical outcomes, clinical registries, retrospective database analyses, and meta-analyses. Provide scientific support for protocol development, target product profiles, data collection strategies, literature review and evidence synthesis Stakeholder Engagement &amp; Communication Oversee the development of peer-reviewed publications, conference presentations, and internal communication of HEOR findings. Support global market access strategy and plans for Amylyx pipeline products including, identifying opportunities for early scientific advice with key health technology assessment (HTA) agencies, regulatory support and preparing for global HTA models. Incorporate any recommendations into the clinical development program. Cross-Functional Collaboration Ensure all HEOR tactics are aligned cross-functionally with business strategies and regulatory guidelines. Monitor and interpret U.S. policy changes (e.g., IRA, CMS guidance) and translate implications into actionable HEOR strategies. Collaborate with Market Access and Medical Affairs to develop and maintain evidence packages tailored to U.S. payers, including commercial plans, Medicare, and Medicaid. Team &amp; Vendor Management Lead vendor selection and manage external research partners to ensure high-quality and timely study delivery. Build and manage a team to support innovative real-world evidence generation and health economics research. Manage HEOR budget planning and resource allocation to ensure efficient execution of strategic priorities REQUIRED QUALIFICATIONS 10+ years healthcare or pharmaceutical industry experience with minimum 7 in HEOR Master's Degree (MS, MPH, PharmD, PhD) in a relevant discipline (e.g., health economics, medicine, pharmacy, public health, epidemiology) required Demonstrated success in designing and leading real-world research to support US payer value and access. Experience supporting HEOR strategy for product launch, including pre-launch evidence generation and payer engagement, is highly desirable. Deep understanding of U.S. healthcare system dynamics, including payer structures, value-based care, and regulatory trends. Excellent leadership and cross-functional collaboration skills, with the ability to influence and drive strategy across teams and with external partners and vendors Excellent analytical skills, including in-depth knowledge of COAs and pharmacoeconomic modeling and retrospective database analysis methodologies. Experience working with U.S. claims databases, EMRs, and patient registries; proficiency in RWE analytics platforms and methodologies. Knowledge of endocrine and/or obesity space a plus Ability to travel up to 20% WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska and Hawaii.&nbsp; You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Health Economics and Outcome Research/Real World Evidence

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY The Senior Director, Patient and Professional Advocacy at Amylyx Pharmaceuticals will report to the SVP of Medical Affairs. The Senior Director will lead the development and execution of strategies to engage patient communities and professional organizations. This role ensures the patient voice is integrated across the product lifecycle—from clinical development to commercialization—while fostering strong, compliant relationships with advocacy groups and healthcare professional societies. RESPONSIBILITIES Strategic Leadership Refine and implement a comprehensive patient and professional advocacy strategy aligned with corporate goals. Serve as the internal champion for patient-centricity and incorporating patient insights into decision-making across functions including Clinical Development, Clinical Operations, Medical Affairs, Commercial, Regulatory, and Communications. Patient Advocacy Build and maintain trusted relationships with patient advocacy organizations. Serve as the primary liaison between the company and external advocacy stakeholders, representing the company with transparency, integrity, and empathy. &nbsp;Lead initiatives to incorporate patient insights into clinical trial design, access strategies, communications, and educational programs. Represent the company at patient-focused events, advisory board meetings, and conferences. Professional Engagement Build and maintain strategic relationships with medical societies and professional organizations to support disease awareness, scientific exchange, and shared advocacy initiatives. Partner with internal stakeholders to align advocacy efforts with scientific and medical strategies. Cross-Functional Collaboration Work closely with Clinical Development, Market Access, Corporate Communications, Regulatory, and Legal/Compliance to ensure integrated and compliant engagement. Support internal training and awareness to deepen employee understanding of the patient experience and to educate on patient advocacy best practices. Compliance &amp; Governance Ensure all advocacy activities comply with regulatory, legal, and ethical standards. Manage sponsorships, grants, and partnerships in alignment with company policies. REQUIRED QUALIFICATIONS Bachelor’s degree required; advanced degree in life sciences, public health, or related field preferred. 10+ years of experience in patient advocacy, public affairs, or related roles in the pharmaceutical or biotech industry. Proven track record of building global advocacy strategies and partnerships. Deep understanding of healthcare systems, regulatory frameworks, and patient engagement trends. Experience in rare diseases or specialty therapeutics is a plus. Strong communication, leadership, and cross-functional collaboration skills. Ability to travel up to 20% WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska and Hawaii. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Patient and Professional Advocacy

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx Pharmaceuticals is seeking a strategic and hands-on&nbsp;Senior Manager, Commercial Analytics,&nbsp;to join our growing Commercial team. This individual will play a critical role in shaping data-driven decision-making across our lead indication with Avexitide in&nbsp;Post-Bariatric Hypoglycemia (PBH)&nbsp;and future pipeline programs across assets. The ideal candidate will be a highly analytical thinker with deep expertise in healthcare data, capable of independently executing complex analyses and translating insights into actionable strategies. This role offers the opportunity to work cross-functionally with teams including Marketing, Medical Affairs, Market Access, and Supply Chain, and to present findings directly to senior leadership. If you thrive in a fast-paced, mission-driven environment and are passionate about using data to drive impact, we’d love to meet you. RESPONSIBILITIES Lead commercial analytics efforts across PBH and pipeline products, supporting strategic planning and operational execution. Independently analyze and interpret healthcare datasets (e.g., claims, specialty pharmacy, EMR) using SQL, Excel, and other tools to uncover insights on patient journeys, provider behavior, and market dynamics. Develop and maintain dashboards and reports that support commercial performance tracking and forecasting. Translate complex data findings into clear, compelling presentations for cross-functional stakeholders and senior leadership. Partner with Marketing, Medical Affairs, Market Access, and Supply Chain to align analytics with business needs and strategic priorities. Support launch readiness and post-launch performance tracking for new products and indications. Identify opportunities for data acquisition and infrastructure improvements to enhance analytics capabilities. Collaborate with external vendors and data providers to ensure quality and relevance of third-party data sources. Stay current on industry trends, competitive intelligence, and emerging data methodologies to continuously elevate the analytics function. REQUIRED QUALIFICATIONS 5+ years BA/BS, 3+ years MA/MS Prior experience in consulting (with focus in pharmaceutical industry), or in a commercial operations / analytics function at a pharmaceutical company Experience working with healthcare data – claims data, EMR/EHR, specialty pharmacy data etc. Experience with financial modeling / forecasting Experience in SQL / Other Database Language PREFERRED REQUIREMENTS Experience working in rare diseases is a plus Experience supporting multiple brands / indications is a plus Experience with Python is a plus Experience in advanced market segmentation approaches (e.g., HCP, patient) is a plus WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Delaware, Hawaii and Kansas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Manager, Commercial Analytics

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.THE OPPORTUNITY As a key member of the Commercial Leadership Team, the Vice President, Commercial Operations will establish and lead the commercial operations function, ensuring the infrastructure, processes, and strategies necessary for successful product commercialization. This role oversees sales operations, forecasting and analytics, incentive compensation, market research, data management, CRM systems, field effectiveness, and commercial training. The leader in this role will act as a strategic partner across multiple functions, including Sales, Marketing, Market Access, Patient Services, Medical Affairs, Finance, IT, and Compliance, to drive commercial excellence and business growth. This role offers an opportunity to shape the Commercial Operations function from the ground up, supporting a high-impact product launch and long-term business growth. RESPONSIBILITIES Commercial Strategy &amp; Leadership Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operational plans. Oversee the design and optimization of commercial operations, including market research, forecasting, data analytics, sales reporting, and performance tracking. Develop a best-in-class commercial infrastructure that aligns with business objectives and supports pre-launch and post-launch activities. Lead Quarterly Business Reviews (QBR) and Board of Directors (BoD) process preparation, including performance reporting and insights. Partner cross-functionally with Marketing, Sales, Finance, Compliance, Market Access, and Medical Affairs to drive aligned strategic execution. Sales &amp; Field Operations Design and implement field force structure, including sizing, territory alignment, and resource allocation. Oversee field effectiveness, including CRM system implementation, sales enablement tools, and customer engagement reporting. Develop and manage incentive compensation plans to motivate and retain top sales talent while ensuring compliance. Establish field insights and reporting frameworks, providing timely and data-driven recommendations to sales leadership. Support field training and development programs in collaboration with Sales Training teams. Market Insights, Analytics &amp; Data Management Lead the development and governance of commercial data strategy, ensuring seamless integration and utilization of sales, claims, specialty pharmacy, and CRM data. Develop competitive intelligence, customer targeting methodologies, and KPIs to assess commercial performance. Design dashboards, analytics tools, and reporting mechanisms that provide actionable insights for leadership decision-making. Partner with IT and external vendors to build and maintain a commercial data environment (CDE) that supports sales forecasting, revenue tracking, and strategic planning. Operational Excellence &amp; Budget Management Manage commercial operations budgets, ensuring efficient allocation of human and financial resources. Drive process improvements, system enhancements, and operational efficiencies to optimize commercial execution. Oversee congress and event operations, including commercial presence at industry meetings. Ensure compliance with industry regulations and internal policies in all commercial activities. REQUIRED QUALIFICATIONS Bachelor's degree required; MBA or advanced degree preferred. 12+ years in commercial operations, sales analytics, or related functions within the pharmaceutical, biotechnology, or healthcare industry. Experience in&nbsp;rare diseases, specialty pharma, or product launches strongly preferred. Proven ability to build and lead high-performing teams in a fast-paced, evolving environment. Strong business acumen with the ability to analyze complex data, forecast market trends, and drive strategic decision-making. Demonstrated ability to work effectively across multiple departments, influencing senior leadership and cross-functional teams. Experience with CRM systems, sales analytics, market insights, data governance, and incentive compensation design. Strong written and verbal communication skills, with experience presenting insights to executive leadership and board members. Ability to navigate ambiguity, prioritize initiatives, and implement innovative commercial solutions. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. While this is a remote role, preference will be given to candidates who reside within New England and can attend meetings at our office in Cambridge, MA on an as-needed basis. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Vice President, Commercial Operations

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Amylyx is seeking a Director of Employee Relations and HR Operations Partner to help shape and support the dynamic growth of our organization. The incumbent will serve as a trusted advisor and central point of expertise for all employee relations matters while also playing a key role in supporting the broader HR function. This leader will design and oversee the frameworks, policies, and practices that shape the employee experience – ensuring our culture remains strong, inclusive, and high-performing as we scale.&nbsp; In addition, this leader drives consistency, fairness, and compliance across the organization while strengthening our culture of trust, accountability and performance. This individual will focus on the day-to-day realities of the employee journey—from navigating workplace challenges to reinforcing performance expectations—while partnering closely with the Talent Management &amp; Development team (who leads onboarding, training, development, and coaching), and with HR Business Partners as the organization expands. The Director will bring balance: empathetic support for employees, clear guidance for managers, and sound judgment that protects the business. Responsibilities Employee Relations Leadership Lead the company’s employee relations strategy and practices, ensuring a fair, consistent, and values-based approach to all workplace matters. Conduct, oversee, and document internal investigations in collaboration with Legal and the CHRO. Advise leaders and managers on performance management, corrective action, and workplace conflict resolution. Partner with HR and Legal to ensure policies are up to date, employee-friendly, and compliant with applicable laws. Identify ER trends and proactively recommend training or process improvements to strengthen organizational health and prevent recurrence. Manage and resolve employee concerns, investigations, and corrective actions with discretion and integrity. Coach and develop HR team members and managers on effective employee relations practices and documentation standards. HR Functional &amp; Business Partnership Support Act as a connective point across the HR functions supporting HR Business Partners, Talent Acquisition, Total Rewards, and HRIS to ensure aligned, consistent delivery of HR programs. Partner with HRBPs to advise on organizational design, workforce planning, and performance-related interventions. Contribute to annual HR processes, including performance reviews, compensation planning, talent calibration, and engagement initiatives. Support cross-functional HR initiatives and special projects that advance HR infrastructure, operational excellence, and employee experience. Serve as a thought partner to the HR leadership team on policy interpretation, communications, and change-management efforts. Compliance &amp; Culture Stewardship Lead the development, administration and rollout of HR policies. Ensure compliance with federal, state, and local employment laws (e.g., EEO, FMLA, ADA, wage and hour). Partner closely with Legal on sensitive employee matters, audits, and risk assessments. Promote a culture of inclusion, accountability, and mutual respect that aligns with company values and business goals. Develop and deliver training for managers on policies, performance management, and respectful workplace behaviors. Partner with HR Business Partners to ensure consistent application across the organization. Collaborate with Legal and HR leadership on sensitive matters including terminations, restructures, and compliance audits. Serve as a point of guidance for the HR and Legal team on complex policy questions related to our employees.&nbsp; Flexibility &amp; Growth Mindset Embrace the dynamic environment of a growing biotech organization, recognizing that responsibilities may evolve as we scale. Be willing to take on projects and initiatives outside the typical scope of the role in order to support the team and the company’s success. Demonstrate a proactive, hands-on approach—jumping in where needed, whether that’s building new processes, supporting cross-functional initiatives, or helping colleagues problem-solve in real time. Required Qualifications A Bachelor’s degree in Human Resources, Business Administration or related field; Master’s degree preferred. Equivalent professional experience will also be considered in place of a degree; we value demonstrated expertise, hands-on leadership, and a proven track record of success just as highly as formal education. 10+ years of progressive HR experience, including at least 5 years focused on employee relations in a complex or scaling organization. Deep understanding of U.S. employment law and best practices in HR and employee relations. Proven ability to manage complex investigations and advise senior leaders with sound business judgment and discretion. Exceptional interpersonal and communication skills; ability to navigate sensitive situations with discretion. Demonstrated success in building scalable employee relations frameworks in dynamic, growing organizations. Friendly, flexible, and comfortable operating in a fast-paced, evolving biotech environment. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$197,000&mdash;$222,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Employee Relations and HR Operations Partner

Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, with an audacious mission to develop novel therapies for high unmet needs. We are currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – create a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and determination, we encourage you to read the opportunity below and apply.The Opportunity Amylyx is looking for an Associate Director, Drug Substance, to join our CMC and External Manufacturing team. In this role you will be the technical development drug substance owner for Amylyx’s Phase III synthetic peptide, Avexitide, and pre-clinical antisense oligonucleotide, AMX-0114. This position will work directly with external CDMOs to develop, scale-up, and validate drug substance processes. This role will be an individual contributor, however, it is a highly collaborative and visible role. You will be a key member of asset CMC teams. This role reports to the Senior Vice President, Global CMC and External Manufacturing. Responsibilities Lead CMC drug substance phase appropriate process development activities from Phase 1 through NDA ensuring Module 3 content supports global clinical filings and registration plans Serve as the technical SME and process owner for drug substance. Working with contract manufacturing organizations, develop scalable and robust manufacturing processes for oligonucleotides and peptide products Evaluate new CDMOs to support tox and clinical material needs. Serve as the technical SME on all DS tech transfer projects Monitor drug substance GMP operations including clinical batch record review, and process data trending and support of related quality events. Author IND and NDA Module 3, Master Batch Records, Validation Plans and Reports Understand regulatory plans for all proposed changes, minimizing risk to product supply Foster effective teamwork and drive project execution. Proactively track critical path activities, anticipate risks, create contingency plans and decision-making exercises in collaboration with project teams. Provide input to project timelines and budgets and communicate progress Regularly interacts with key CMC team members including Regulatory, Quality, Analytical Development, Supply Chain, and External Manufacturing Travel to global manufacturing sites to support operations and validation activities Required Qualifications Bachelor’s degree in organic chemistry, chemical engineering, or related field. MS preferred A solid understanding of small molecule, RNA, and amino acid chemistries At least 5 years of experience in API process development from early through late-phase. Prior process validation experience preferred Experience developing oligonucleotide and/or synthetic peptide manufacturing processes including impurity control strategies Advanced knowledge of cGMP/GLP regulations, ICH, FDA CMC Guidance Documents A strong track record of successful global CMC submissions and approvals Must be able to function independently and influence appropriate stakeholders and recommend scientifically rigorous, phase appropriate, risk-management based solutions to complex technical challenges Experience working with contract manufacturing organizations Excellent communication and teamwork skills Ability to travel internationally up to 10% Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Drug Substance

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY We are seeking an R&amp;D and Preclinical Operations Coordinator to provide operational and administrative support to a small, highly collaborative preclinical R&amp;D team, including toxicology, bioanalytical, and research staff. This role partners closely with scientists and external vendors to support study execution by managing scheduling, documentation, vendor coordination, and procurement processes, enabling the scientific team to remain focused on execution and data generation. This is an excellent opportunity for an early-career professional interested in building a career in biotech operations, with exposure to preclinical development, CRO engagement, and cross-functional collaboration. RESPONSIBILITIES Provide day-to-day operational and administrative support to preclinical scientists, toxicologists, research associates, and bioanalytical staff. Partner with Procurement, Legal, and Finance to support vendor onboarding, contract initiation and life cycle management, purchase orders, and invoice tracking. Support study planning activities through scheduling meetings, coordinating timelines, and tracking key milestones. Assist with organization and maintenance of documentation related to operations of preclinical and toxicology studies, including protocols, reports, contracts, invoices, and key communications. Maintain organized records of vendor agreements, statements of work, and study-related documentation. Support the Senior Director, Preclinical and Translational Sciences with calendar management, meeting preparation, and follow-up actions. Coordinate internal and cross-functional meetings, including agenda preparation and meeting notes when needed. Assist with budget tracking and spend visibility for preclinical and toxicology activities in partnership with Finance and Procurement. Help establish and maintain operational processes, templates, and trackers to support a growing preclinical organization. Identify opportunities to improve efficiency and consistency across preclinical operations and administrative workflows REQUIRED QUALIFICATIONS Bachelor’s degree in life sciences, business, or a related field. 0-2 years’ experience post degree in a preclinical focused role with external contracts experience. Exposure to preclinical research, toxicology, bioanalytical sciences, or CRO environments, 1-2 years prior experience/exposure. Exposure concurrent with undergraduate work is acceptable. Familiarity with procurement, contracts, or vendor management processes. Proficiency with common business tools such as Microsoft Office. Experience with LinkSquares and/or Net Suite is a plus. Strong organizational skills with the ability to manage multiple priorities in a fast-paced environment. Excellent communication skills and comfort working with both internal teams and external vendors. Proficiency with common business tools such as Microsoft Office. Experience with LinkSquares and/or Net Suite is a plus. Prior experience in an administrative, operations, or coordinator role within biotech, pharma, or life sciences is preferred. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$74,000&mdash;$83,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

R&D Operations Coordinator

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Amylyx is seeking a highly motivated professional with accounting experience who can apply accepted accounting principles and procedures to analyze financial information, prepare accurate and timely results, and ensure appropriate accounting control procedures. This position will be a key member of a cross-functional accounting team. The individual will be responsible for managing critical accounting areas, reconciliations, corporate accruals and ad hoc reporting. This position will have significant interaction with Amylyx business leaders. RESPONSIBILITIES Month-End Close: Assist with the month-end close process to ensure timely, accurate, and complete financial reporting. Prepare journal entries for cash, investments, prepaid expenses, SG&amp;A accruals, T&amp;E, stock option exercises, and RSU vesting. Perform foreign currency translation and revaluation, ensuring accuracy of currency translation adjustments (CTA) and validation of exchange rates. Oversee the preparation and distribution of monthly financial reports to internal stakeholders. Ensure the preparation and review of intercompany journal entries and balances. Financial Reporting: Ensure internal financial reports are accurate, up to date, and aligned with business needs. Ensure compliance with financial reporting controls and maintain accuracy in reports used for internal control purposes. Prepare balance sheet reconciliations, ensuring completeness and accuracy. Prepare and oversee balance sheet and income statement flux analysis, comparing current periods with prior periods and the prior year. Lead the preparation and coordination of foreign statutory financial statements, including managing audits in collaboration with PwC. NetSuite and FloQast Management: Serve as the NetSuite administrator, responsible for maintaining accounts, departments, project codes, and GEO codes, ensuring approval processes are followed. Develop, enhance, and maintain NetSuite reports to support internal financial and operational needs. Oversee NetSuite cash reconciliation processes and identify opportunities to leverage additional modules. Administer FloQast by adding new users, assigning reconciliations, and maintaining the month-end close checklist. Lead user access reviews for both NetSuite and FloQast to ensure appropriate permissions are maintained. Tax &amp; Treasury Support: Act as the primary point of support for the Head of Tax and Treasury, providing analysis and data for tax compliance and statutory reporting. Assist with the preparation and review of tax-related disclosures and support the tax filing process. REQUIRED QUALIFICATIONS Bachelor’s degree in Accounting or Finance 4+ years of progressive accounting experience Experience with ERP systems, particularly NetSuite Advanced proficiency with Microsoft Excel and other Office products PREFERRED QUALIFICATIONS CPA designation or progress toward obtaining a CPA. Experience working in a public company environment or with a Big 4 accounting firm. Knowledge of international statutory reporting requirements and foreign currency transactions. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$97,000&mdash;$109,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Accountant

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Our Regional Scientific Director (RSD), with support and guidance from peers and leadership, will serve as a field based scientific, medical experts to the medical/academic community and is responsible for establishing and maintaining relationships with Key Opinion Leaders (KOLs) and Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Amylyx’s compounds in a timely, ethical and stakeholder-focused manner. The RSD will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the design and execution of the Medical Affairs strategy and plan. The RSD will engage HCPs in response to scientific educational and research needs with available Amylyx resources and provide the latest emerging data in response to specific inquiries, as appropriate. What sets this job apart: In this role you will provide credible and unbiased scientific information, identifying, and executing strategic medical affairs projects and supporting home office medical activities.&nbsp; Developing strong relationships with key institutions and practices to understand the provider and patient journey, study capabilities and opportunities to apply local medical resources to improve patient care. You will serve as an educator for the medical and advocacy community by driving disease awareness and addressing unmet medical needs. You will participate in the planning and execution of advisory board meetings and other programs including development of topics, slide content and review of data with speakers. You will work with regional and national account teams to deliver presentations to payers in support of patient access. Preference will be given to candidates who reside in the Houston, Dallas, Austin or New Orleans areas. RESPONSIBILITIES Respond to questions from KOLs and HCPs with fair and balanced scientific, medical responses Manage questions around safety, adherence and off label data on Amylyx’s products Provide ongoing medical/scientific education to Amylyx’s field and HQ teams Support clinical initiatives including site identification, trial recruitment, registry and presentation of final approved data Conduct regular and extensive reviews of literature, develop presentations and assist with publications and medical communications Develop and execute prioritized plans for KOLs/institutions/societies Develop and execute a strategic, innovative territory plan of medical and therapeutic area objectives, in collaboration with Scientific Communication, Real World Evidence and medical directors, to address the specific needs of key institutions and KOLs Represent Amylyx medical affairs at medical congresses, educating on Amylyx’s pipeline products, collecting competitive intelligence and reviewing data (symposia, abstracts, poster presentations, etc.) Identify and support data generation projects, content development and review of scientific education materials, clinical site participation and internal publications Support commercial team functions including facilitating internal training, speaker training programs, internal scientific material review and competitive insights into therapeutic area planning Conceptual and practical knowledge of local and regional payers within the geography and understands the relationships between those plans and patient care delivery in the region Maintain compliance with all internal and external legal and regulatory guidelines REQUIRED QUALIFICATIONS Advanced degree (e.g., PhD, PharmD, DNP, DHSc, or MD) 8 plus years of experience as a field medical scientist (Medical Science Liaison) preferred OR relevant experience in medical affairs: Regional Scientific Director Experience driving medical affairs projects [data generation projects, abstracts, education materials] Excellent presentation, communication, and project management skills Ability to understand and effectively communicate scientific/medical benefits of pharmaceutical products to the medical community Strong data analysis skills Demonstrated ability to effectively facilitate meetings Ability to work independently and function successfully as a team member Office is home based. Must be able to travel within assigned region 3-4 days per week including overnight stays Travel to medical meetings, team meetings and other group meetings (will require some weekends) Must have a valid driver’s license PREFERRED QUALIFICATIONS: Endocrinology and rare disease experience, Neuromuscular disorders experience beneficial Well-established networks with endocrinology KOLs&nbsp; WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.&nbsp; Preference will be given to candidates who reside in the Houston, Dallas, Austin or New Orleans. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp; &nbsp;Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$222,000&mdash;$250,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Regional Scientific Director, Central

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Our Regional Scientific Director (RSD), with support and guidance from peers and leadership, will serve as a field based scientific, medical experts to the medical/academic community and is responsible for establishing and maintaining relationships with Key Opinion Leaders (KOLs) and Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Amylyx’s compounds in a timely, ethical and stakeholder-focused manner. The RSD will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the design and execution of the Medical Affairs strategy and plan. The RSD will engage HCPs in response to scientific educational and research needs with available Amylyx resources and provide the latest emerging data in response to specific inquiries, as appropriate. What sets this job apart: In this role you will provide credible and unbiased scientific information, identifying, and executing strategic medical affairs projects and supporting home office medical activities.&nbsp; Developing strong relationships with key institutions and practices to understand the provider and patient journey, study capabilities and opportunities to apply local medical resources to improve patient care. You will serve as an educator for the medical and advocacy community by driving disease awareness and addressing unmet medical needs. You will participate in the planning and execution of advisory board meetings and other programs including development of topics, slide content and review of data with speakers. You will work with regional and national account teams to deliver presentations to payers in support of patient access. Preference will be given to candidates who reside in the NYC, Philadelphia or Chicago areas. RESPONSIBILITIES Respond to questions from KOLs and HCPs with fair and balanced scientific, medical responses Manage questions around safety, adherence and off label data on Amylyx’s products Provide ongoing medical/scientific education to Amylyx’s field and HQ teams Support clinical initiatives including site identification, trial recruitment, registry and presentation of final approved data Conduct regular and extensive reviews of literature, develop presentations and assist with publications and medical communications Develop and execute prioritized plans for KOLs/institutions/societies Develop and execute a strategic, innovative territory plan of medical and therapeutic area objectives, in collaboration with Scientific Communication, Real World Evidence and medical directors, to address the specific needs of key institutions and KOLs Represent Amylyx medical affairs at medical congresses, educating on Amylyx’s pipeline products, collecting competitive intelligence and reviewing data (symposia, abstracts, poster presentations, etc.) Identify and support data generation projects, content development and review of scientific education materials, clinical site participation and internal publications Support commercial team functions including facilitating internal training, speaker training programs, internal scientific material review and competitive insights into therapeutic area planning Conceptual and practical knowledge of local and regional payers within the geography and understands the relationships between those plans and patient care delivery in the region Maintain compliance with all internal and external legal and regulatory guidelines REQUIRED QUALIFICATIONS Advanced degree (e.g., PhD, PharmD, DNP, DHSc, or MD) 8 plus years of experience as a field medical scientist (Medical Science Liaison) preferred OR relevant experience in medical affairs: Regional Scientific Director Experience driving medical affairs projects [data generation projects, abstracts, education materials] Excellent presentation, communication, and project management skills Ability to understand and effectively communicate scientific/medical benefits of pharmaceutical products to the medical community Strong data analysis skills Demonstrated ability to effectively facilitate meetings Ability to work independently and function successfully as a team member Office is home based. Must be able to travel within assigned region 3-4 days per week including overnight stays Travel to medical meetings, team meetings and other group meetings (will require some weekends) Must have a valid driver’s license PREFERRED QUALIFICATIONS: Endocrinology and rare disease experience, Neuromuscular disorders experience beneficial Well-established networks with endocrinology KOLs&nbsp; WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.&nbsp; Preference will be given to candidates who reside in the NYC, Philadelphia or Chicago areas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. &nbsp;Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$222,000&mdash;$250,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Regional Scientific Director, Northeast

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Our Regional Scientific Director (RSD), with support and guidance from peers and leadership, will serve as a field based scientific, medical experts to the medical/academic community and is responsible for establishing and maintaining relationships with Key Opinion Leaders (KOLs) and Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Amylyx’s compounds in a timely, ethical and stakeholder-focused manner. The RSD will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the design and execution of the Medical Affairs strategy and plan. The RSD will engage HCPs in response to scientific educational and research needs with available Amylyx resources and provide the latest emerging data in response to specific inquiries, as appropriate. What sets this job apart: In this role you will provide credible and unbiased scientific information, identifying, and executing strategic medical affairs projects and supporting home office medical activities.&nbsp; Developing strong relationships with key institutions and practices to understand the provider and patient journey, study capabilities and opportunities to apply local medical resources to improve patient care. You will serve as an educator for the medical and advocacy community by driving disease awareness and addressing unmet medical needs. You will participate in the planning and execution of advisory board meetings and other programs including development of topics, slide content and review of data with speakers. You will work with regional and national account teams to deliver presentations to payers in support of patient access. Preference will be given to candidates who reside in the Orlando, Miami, Memphis or Atlanta areas. RESPONSIBILITIES Respond to questions from KOLs and HCPs with fair and balanced scientific, medical responses Manage questions around safety, adherence and off label data on Amylyx’s products Provide ongoing medical/scientific education to Amylyx’s field and HQ teams Support clinical initiatives including site identification, trial recruitment, registry and presentation of final approved data Conduct regular and extensive reviews of literature, develop presentations and assist with publications and medical communications Develop and execute prioritized plans for KOLs/institutions/societies Develop and execute a strategic, innovative territory plan of medical and therapeutic area objectives, in collaboration with Scientific Communication, Real World Evidence and medical directors, to address the specific needs of key institutions and KOLs Represent Amylyx medical affairs at medical congresses, educating on Amylyx’s pipeline products, collecting competitive intelligence and reviewing data (symposia, abstracts, poster presentations, etc.) Identify and support data generation projects, content development and review of scientific education materials, clinical site participation and internal publications Support commercial team functions including facilitating internal training, speaker training programs, internal scientific material review and competitive insights into therapeutic area planning Conceptual and practical knowledge of local and regional payers within the geography and understands the relationships between those plans and patient care delivery in the region Maintain compliance with all internal and external legal and regulatory guidelines REQUIRED QUALIFICATIONS Advanced degree (e.g., PhD, PharmD, DNP, DHSc, or MD) 8 plus years of experience as a field medical scientist (Medical Science Liaison) preferred OR relevant experience in medical affairs: Regional Scientific Director Experience driving medical affairs projects [data generation projects, abstracts, education materials] Excellent presentation, communication, and project management skills Ability to understand and effectively communicate scientific/medical benefits of pharmaceutical products to the medical community Strong data analysis skills Demonstrated ability to effectively facilitate meetings Ability to work independently and function successfully as a team member Office is home based. Must be able to travel within assigned region 3-4 days per week including overnight stays Travel to medical meetings, team meetings and other group meetings (will require some weekends) Must have a valid driver’s license PREFERRED QUALIFICATIONS: Endocrinology and rare disease experience, Neuromuscular disorders experience beneficial Well-established networks with endocrinology KOLs&nbsp; WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.&nbsp; Preference will be given to candidates who reside in the Orlando, Miami, Memphis or Atlanta areas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$222,000&mdash;$250,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Regional Scientific Director, Southeast

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY Our Regional Scientific Director (RSD), with support and guidance from peers and leadership, will serve as a field based scientific, medical experts to the medical/academic community and is responsible for establishing and maintaining relationships with Key Opinion Leaders (KOLs) and Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Amylyx’s compounds in a timely, ethical and stakeholder-focused manner. The RSD will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the design and execution of the Medical Affairs strategy and plan. The RSD will engage HCPs in response to scientific educational and research needs with available Amylyx resources and provide the latest emerging data in response to specific inquiries, as appropriate. What sets this job apart: In this role you will provide credible and unbiased scientific information, identifying, and executing strategic medical affairs projects and supporting home office medical activities.&nbsp; Developing strong relationships with key institutions and practices to understand the provider and patient journey, study capabilities and opportunities to apply local medical resources to improve patient care. You will serve as an educator for the medical and advocacy community by driving disease awareness and addressing unmet medical needs. You will participate in the planning and execution of advisory board meetings and other programs including development of topics, slide content and review of data with speakers. You will work with regional and national account teams to deliver presentations to payers in support of patient access. Preference will be given to candidates who reside in the Los Angeles or San Francisco areas. RESPONSIBILITIES Respond to questions from KOLs and HCPs with fair and balanced scientific, medical responses Manage questions around safety, adherence and off label data on Amylyx’s products Provide ongoing medical/scientific education to Amylyx’s field and HQ teams Support clinical initiatives including site identification, trial recruitment, registry and presentation of final approved data Conduct regular and extensive reviews of literature, develop presentations and assist with publications and medical communications Develop and execute prioritized plans for KOLs/institutions/societies Develop and execute a strategic, innovative territory plan of medical and therapeutic area objectives, in collaboration with Scientific Communication, Real World Evidence and medical directors, to address the specific needs of key institutions and KOLs Represent Amylyx medical affairs at medical congresses, educating on Amylyx’s pipeline products, collecting competitive intelligence and reviewing data (symposia, abstracts, poster presentations, etc.) Identify and support data generation projects, content development and review of scientific education materials, clinical site participation and internal publications Support commercial team functions including facilitating internal training, speaker training programs, internal scientific material review and competitive insights into therapeutic area planning Conceptual and practical knowledge of local and regional payers within the geography and understands the relationships between those plans and patient care delivery in the region Maintain compliance with all internal and external legal and regulatory guidelines REQUIRED QUALIFICATIONS Advanced degree (e.g., PhD, PharmD, DNP, DHSc, or MD) 8 plus years of experience as a field medical scientist (Medical Science Liaison) preferred OR relevant experience in medical affairs: Regional Scientific Director Experience driving medical affairs projects [data generation projects, abstracts, education materials] Excellent presentation, communication, and project management skills Ability to understand and effectively communicate scientific/medical benefits of pharmaceutical products to the medical community Strong data analysis skills Demonstrated ability to effectively facilitate meetings Ability to work independently and function successfully as a team member Office is home based. Must be able to travel within assigned region 3-4 days per week including overnight stays Travel to medical meetings, team meetings and other group meetings (will require some weekends) Must have a valid driver’s license PREFERRED QUALIFICATIONS: Endocrinology and rare disease experience, Neuromuscular disorders experience beneficial Well-established networks with endocrinology KOLs&nbsp; WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.&nbsp; Preference will be given to candidates who reside in the Los Angeles or San Francisco areas. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$222,000&mdash;$250,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Regional Scientific Director, West

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Amylyx is seeking a Director, Launch Excellence to play a critical role in planning and executing the successful commercial launch of our first product in the endocrinology space. This role will be hired in 2026 and will partner cross-functionally to ensure launch readiness ahead of a potential 2027 product launch. The Director, Launch Excellence will serve as the central coordinator for launch activities—driving disciplined execution, clarity of ownership, and visibility across Commercial, Medical, Clinical, Regulatory, Manufacturing, Market Access, Finance, Legal, and IT. This is a hands-on role requiring strong project leadership, judgment, and the ability to operate effectively in a fast-growing biotech environment. Responsibilities Launch Planning &amp; Execution Lead the end-to-end launch execution plan, including timelines, milestones, dependencies, and risk mitigation activities. Translate high-level launch strategy into actionable, trackable workstreams with clear ownership. Maintain and continuously refine integrated launch plans from pre-approval through post-launch phases. Cross-Functional Program Leadership Act as the single point of coordination across all launch-related functions. Facilitate regular launch governance forums (e.g., launch team meetings, executive readouts). Ensure continuous alignment across Commercial, Medical Affairs, Market Access, Supply Chain, Regulatory, and other key stakeholders. Readiness &amp; Risk Management Proactively identify launch risks, gaps, and interdependencies; develop mitigation plans and escalate as needed. Track launch readiness metrics and ensure timely decision-making. Support scenario planning tied to regulatory timing, supply readiness, and market dynamics Tools, Process &amp; Communication Implement and manage launch project management tools, dashboards, and reporting mechanisms. Drive consistent ways of working, documentation standards, and decision logs. Prepare detailed and clear executive-level communications and launch status updates Continuous Improvement Capture lessons learned and best practices to support future indications or lifecycle expansion. Help build scalable launch excellence capabilities appropriate for a growing biotech organization. Requirements Bachelor’s degree required; advanced degree (MBA, MPH, MS) preferred. 10+ years of experience in pharmaceutical or biotech launch, commercial operations, or enterprise project management. Direct experience supporting product launch readiness in the U.S. market. Proven ability to lead complex, cross-functional initiatives without direct authority. Strong organizational, communication, and stakeholder management skills. Fluency with project management tracking tools (e.g., MS Project, Smartsheets, MS Excel), and advanced MS PowerPoint skills Comfortable operating in ambiguity and adapting as strategy and timelines evolve. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$212,000&mdash;$238,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Launch Excellence

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.THE OPPORTUNITY The Vice President, Biostatistics will lead a team of Biostatisticians and play a pivotal role in driving the statistical the design, analysis, reporting and interpretation of clinical studies. This highly interactive role will work closely with Clinical, Regulatory, Statistical Programming, Data Management, and other cross- functional experts.&nbsp; The Vice President, Biostatistics will build and maintain effective strategic working relationships with internal and external partners to meet business needs. This position will oversee the strategic planning of clinical development plans, as well as regulatory and commercial strategies to ensure that study designs are consistent with program objectives and meet worldwide regulatory and marketing needs. RESPONSIBILITIES Provide a strategic leadership role in the Biometrics Team and cross-departmental program team to ensure the biometrics scopes and timelines defined to meet the corporate objectives Lead and manage the biostatistics team and provide statistical strategies to drug development including development plans, innovative or adaptive study designs, and cross-study analyses including basic and complex statistical methodology implementation, data interpretations, regulatory submissions Act at the lead presenter of statistical data and results of clinical trials to senior management, regulatory agencies, or individual investigators Oversee execution of statistical tasks, resources, timelines and budgets for the function Provide guidance and support to develop individual protocols and data analysis plans and determine appropriate statistical methodologies for analysis; analyze data and interpret results from clinical trials to meet objectives of the study protocol Mentor biostatisticians and oversee execution of major statistics deliverables and milestones in collaboration with other functions Build and maintain a partnership with CROs or individual consultants as needed, provide statistical oversight to tasks outsourced and assure adequate quality and consistency with company and industry standards Participate and collaborate in database design meetings as needed to ensure high quality data evaluated and analysis requirements satisfied Review and approve responses to queries relating to study design, analysis, and interpretation posed by the clinical monitors, regulatory agencies, and/or investigators Review and ensure the accuracy of Statistical Review Aids submitted to regulatory agencies Ensure compliance with GCP and other regulatory requirements REQUIRED QUALIFICATIONS PhD or equivalent advanced degree in statistics/biostatistics with 12+ years relevant work experience within pharmaceutical or biotechnology industry Exemplary leadership, strategic thinking, and technical expertise in statistical analysis, with a proven track record of leading a high performing biometrics team Expert knowledge of statistical methodologies such as longitudinal data analysis, Bayesian modeling and adaptive designs Working knowledge of statistical and data processing software e.g., SAS and/or R Good understanding of worldwide regulatory requirements and clinical trial expertise from early phase to late phase. NDA/MAA submission experience is desired Strong oral and written communication skills. Ability to function effectively in a team and cross-functional environment Advanced knowledge of the pharmaceutical industry, and overall drug development process Strong project management skills. An understanding of biology of disease and drug discovery. WORK LOCATION AND CONDITIONS At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$312,000&mdash;$351,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Vice President, Biostatistics

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Amylyx is looking for a highly experienced Senior Director, Chemistry, Manufacturing, and Controls (CMC), to lead the CMC organization to develop Amylyx’s pipeline including Phase III synthetic peptide, Avexitide, and Phase I antisense oligonucleotide, AMX0114. The CMC group works with external CDMOs to develop robust, scalable, compliant processes for clinical and commercial supply. The Senior Director may lead directly or manage the leads of internal matrix CMC Asset teams and represent CMC on Asset program teams. This leader will work cross-functionally to drive technical excellence and ensure CMC readiness and alignment to program goals. The ideal candidate will combine strong strategic leadership while working closely with teams and actively contributing to hands-on execution when needed. This role reports to the Senior Vice President, Global CMC and External Manufacturing. Responsibilities Strategic Leadership Partner with Regulatory, Quality, Analytical Development, Supply Chain, and External Manufacturing teams to execute CMC strategies for drug development from early-phase through commercialization aligned with asset development plans. Foster effective teamwork and drive project execution. Proactively track critical path activities, anticipate risks, create contingency plans and decision-making exercises in collaboration with project teams. Provide guidance on timelines, budgets, and risk mitigation strategies. Evaluate new CDMOs to support tox and clinical material needs. Provide technical leadership for all due diligence and tech transfer projects. Travel to global manufacturing sites to support development operations and foster collaboration. CMC Leadership Manage CMC leads and/or lead key matrix CMC Asset teams when needed. Author and/or review CMC sections of IND, NDA, and global regulatory submissions (Module 3). Ensure compliance with cGMP, ICH guidelines, and FDA CMC requirements. Process Development &amp; Scale-Up Lead phase-appropriate process development, optimization, and validation activities. Recommend scientifically rigorous, phase-appropriate, risk management-based solutions to complex technical challenges. Develop impurity control strategies and ensure processes meet global regulatory standards. Serve as the technical subject matter expert (SME) and process owner when needed. Drive successful technology transfers and monitor clinical manufacturing operations, including batch record review and data trending. Project Management Lead and mentor a team of technical professionals, fostering a culture of collaboration, accountability, and continuous improvement. Provide career development guidance, performance feedback, and succession planning for team members. Allocate resources effectively across projects and ensure alignment with organizational priorities. Promote technical excellence through coaching, training, and knowledge-sharing initiatives. Drive engagement and retention by creating an inclusive and supportive work environment. Required Qualifications Advanced degree in chemistry, chemical engineering, or related field. A solid understanding of small molecule, RNA, and peptide/amino acid chemistries. At least 15 years of experience in technical process development from early through late phase. Prior process validation experience preferred. Expertise in developing phase-appropriate oligonucleotide and/or synthetic peptide manufacturing processes. Advanced knowledge of cGMP/GLP regulations, ICH, FDA, EMA, JP CMC Guidance Documents. A strong track record of successful global CMC submissions and approvals. Must be able to function independently, influence appropriate stakeholders, and build relationships internally and externally. Experience partnering with contract manufacturing organizations. Excelling leadership, communication, and collaboration skills. Ability to travel internationally up to 10%. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$246,000&mdash;$277,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, CMC

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Senior Director, Marketing Excellence, will play a pivotal role in shaping Amylyx’s commercial strategy and driving seamless, integrated engagement across all customer touchpoints. This leader will be responsible for designing and executing a comprehensive, enterprise-wide omnichannel vision that connects with healthcare professionals and community members (patients and caregivers) through personalized, high-impact experiences. This role will integrate digital and traditional channels, leverage data-driven insights, and collaborate across functions to ensure alignment with brand objectives and launch plans. As a key strategic leader, you will shape how Amylyx engages customers, driving innovation and measurable impact. This role will also lead Marketing Operations with a focus on excellence across all aspects of Marketing. This is a unique opportunity for a strategic, forward-thinking marketer to define how Amylyx leverages technology, analytics, and creative storytelling to deliver consistent, high-value engagement. By combining strategic insight with flawless execution, this individual will help position Amylyx as a leader in omnichannel excellence within the life sciences industry. Responsibilities Lead the enterprise-wide digital and omnichannel vision for Amylyx, establishing the standards, principles, and operating model that guide customer engagement across all channels. Develop and execute an integrated omnichannel marketing capability and strategy aligned with brand objectives and launch timelines, supported by a robust digital customer engagement capability roadmap. Define and optimize end-to-end customer journeys for HCPs and community members to ensure personalized, consistent experiences across personal and nonpersonal touchpoints, overseeing campaign execution across CRM, marketing automation platforms, and third-party media. Partner with brand teams to advise on the creation of compelling, compliant, audience-appropriate content while ensuring alignment with regulatory requirements. Collaborate cross functionally with Commercial, Medical Affairs, and Corporate Communications to ensure seamless integration and synergy across all customer-facing activities. Establish measurement frameworks with KPIs and dashboards to monitor engagement, conversion, and ROI, partnering closely with IT and analytics teams to ensure the data infrastructure supports real-time optimization. Drive continuous improvement by leveraging data driven insights to evolve strategy, enhance performance, and identify new opportunities for customer impact. Oversee governance, optimization, and administration of marketing CRM, marketing automation, analytics platforms, asset management systems, and related martech tools. Oversee congress operations, material distribution, inventory, print/fulfillment, and speaker bureau operations and related budgets. Develop procedures, documentation, and training to ensure compliant, efficient, and repeatable execution across Marketing. Requirements Bachelor’s degree, MBA or advanced degree preferred 10+ years of marketing experience, with at least 5 years in omnichannel or digital marketing leadership roles within biotech/pharma Proven track record of developing and executing integrated marketing strategies for product launches Deep understanding of regulatory and compliance requirements in the life sciences industry Strong analytical skills and experience with marketing technology platforms (CRM, automation, analytics) Exceptional leadership, communication, and project management skills Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.&nbsp; Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$239,000&mdash;$269,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Marketing Excellence

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Amylyx Pharmaceuticals is looking for an Associate Director, Regulatory Medical Writing who will work collaboratively cross-functionally to produce documents to support Amylyx development programs.&nbsp; This role requires a strategic thinker with a variety of experience in clinical development with deep insight into how different functions contribute to the success of the company. Responsibilities Work with internal and external subject experts to plan, prepare, edit, and finalize protocols, investigator brochures, synopses, clinical study reports, regulatory documents (INDs/NDAs, annual reports, Orphan Drug Designation applications, Agency Response to Questions, meeting briefing books, etc.). Manage the internal review process, including internal and external technical review, while driving sign-off timelines. Collate materials, both internal and external, and ensure that documents using these materials accurately and concisely reflect appropriate sources of information. Manage Amylyx-standard templates, in accordance with ICH and regulatory guidelines.&nbsp; Implement appropriate document QC procedures in accordance with Amylyx Quality Guidelines. Manage vendors and contractors for production of documents when necessary Requirements Bachelor's degree with 10+ years; or MS with 8+ years; or PhD with 5+ years. Relevant career experience includes managing and producing clinical and regulatory documents. Strong knowledge of FDA/ICH guidelines, GCP and eCTD. Provide leadership and management for complex documentation projects. Technical expertise in Microsoft Office, Adobe Acrobat, document management systems, and familiarity with SharePoint and concepts of structured content management. Experience in coordination and prioritization of multiple projects in a fast-paced environment. Must have proven ability to understand and interpret clinical trial output; summarize complex results and present them in a clear, concise, and scientifically accurate manner to various end users. Fluent in English (oral and written communication) skills. Awareness of pharmaceutical industry needs beyond clinical development and medical affairs. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$179,000&mdash;$201,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Medical Writing

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Amylyx Pharmaceuticals is looking for an Associate Director, Regulatory CMC who will be responsible for regulatory strategy and operations on identified projects, ensuring that Amylyx products comply with and meet regulatory requirements. This role works closely with internal and external teams from Supply Chain, Quality, Contract Manufacturing Organizations, as well as external consultants to advance the company’s portfolio. Responsibilities include representation on project teams, coordination and preparation of regulatory submissions, license renewals and annual registrations/updates as well as recommended changes to ensure continued compliance with applicable regulations. Responsibilities Partners with cross-functional project teams to ensure regulatory timelines and strategies are developed and seamlessly executed upon, enabling successful filings with Global Health Authorities. Provide regulatory guidance on projects including regulatory strategy, requirements for clinical studies and marketing approval in domestic and international markets, strategic development plans (early and late-stage developments), and Health Authority interactions. Identify and communicate both regulatory and project risks, with potential solutions as needed. Lead/support Health Authority interactions related to CMC which includes briefing document preparation, coordination of meeting, preparations with subject matter experts, and documentation of minutes for projects that extend globally (United States, EU, and rest of world). With minimal supervision, work with internal and external partners to manage assigned submission activities, including the preparation of routine correspondence, INDs/CTAs, BLAs/NDAs/MAAs, annual reports, IND/CTA amendments etc. Required Qualifications Bachelor's degree in a scientific discipline or equivalent with a minimum of 8+ years relevant hands-on regulatory experience in pharmaceutical and/or biotechnology companies, advanced life sciences degree preferred. Strong regulatory knowledge of global drug development within one or more therapeutic areas in early and late-stage development, including US/EU clinical trial requirements, manufacturing, and quality. Strong knowledge of drug development and regulatory policy. Demonstrated experience interacting with either the FDA or EMA is required. Demonstrated ability to successfully communicate verbally and in writing to convey complex information or obtain data across multiple disciplines and externally with partners including the FDA, international regulatory authorities, CROs is required. Proficient in pharmaceutical technical writing such as reports, and regulatory submissions is required as is experience reviewing technical documentation and reports. Position may require approximately 5-10% travel Experience with US and ex-US clinical trial submissions Experience with orphan indication(s) working knowledge of accelerated pathways, Breakthrough designation, Fast Track designation, Priority Review, Orphan designation, and Priority Medicines Scheme (PRIME) designation. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$172,000&mdash;$194,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Regulatory CMC

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Quality Operations team is expanding and looking to hire an Associate Director of QC/AD, reporting to the Director of QC/AD. This individual will be responsible for managing analytical development activities to support the Amylyx pipeline including synthetic peptides, antisense oligonucleotides and small molecules. This individual will be responsible for leading phase appropriate analytical profiles of products spanning pre-clinical, clinical and commercial readiness. The ideal candidate will be a motivated, self-starter, willing to actively collaborate cross functionally and excited about the potential to deliver therapies to patients in need. Responsibilities Lead phase-appropriate analytical control strategies for drug substance and drug product development, including specifications and initial shelf-life assignment. Leads method establishment, development and qualification for release, and stability testing of drug substance and drug product for peptides, oligonucleotide and other modalities. Manage and budget analytical activities at various global CMO/CTLS, including method technology transfer across Amylyx programs. Drive robust impurity characterization, profiling, and quantitation of drug substance and drug product across all stages of clinical development with a focus on HPLC and LC/MS. Lead method troubleshooting, optimization and life-cycle management for characterization, release and stability across multiple programs, through direct oversight of CMO/CTLS. Collaborate cross functionally with teams including Preclinical R&amp;D, External Manufacturing, Regulatory and Quality leadership to develop strategies and deliver on key objectives. Author, review and approve documentation including technical reports, SOPs, test methods, specifications and CMC sections of regulatory filings. Travel may be required up to 10%, which may include on-site review of third-party laboratory and manufacturing operations. Required Qualifications BA/BS, MS or PhD in chemistry, biochemistry or related discipline with at least 8+ years of experience. At least 6+ years of industry experience within Analytical Development and/or Quality Control. Technical expertise in the development of analytical methods for peptides and/or oligonucleotide products is required. Environmental monitoring investigations to support sterile drug product experience is a plus. Ability to analyze, trend, interpret, organize and present data (experience with JMP and/or other statistical software preferred) Demonstrated knowledge of cGMP/ICH/FDA/EU/PMDA regulations Highly collaborative team player with strong communication skills Ability to prioritize responsibilities and multi-task in a fast-paced environment with changing priorities Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$164,000&mdash;$184,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Quality Control & Analytical Development

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity We are seeking an experienced Contracts Manager to help refine and scale our contracting operations as we prepare for a potential drug launch. This role will own the full contract lifecycle process—from intake and template selection through negotiation support, execution, and post execution management. This is a highly visible, customer service oriented role that will serve as the internal subject matter expert and trainer for Amylyx’s contract lifecycle management system (CLMS). The ideal candidate will have a strong background in contract management within the life sciences, biotech, or pharmaceutical industry and thrive in a fast moving, evolving environment. Responsibilities Optimize and implement contracting processes and best practices, ensuring efficient workflows, compliance, and continuity across teams. Manage end-to-end contract lifecycle for a broad set of contracts, e.g. services, confidentiality, research collaborations, and other commercial or operational contracts. Maintain the contract management system and repository, including metadata accuracy, key date tracking, renewal management, obligation monitoring, tags, parties and reporting. Partner closely with internal stakeholders (Legal, Compliance, Finance, Procurement, Clinical, Commercial, and other business partners) to ensure contract terms align with business and compliance needs. Develop, update, and maintain contract templates and playbooks in partnership with Legal advisors. Develop and maintain CLMS training materials and provide new hire and refresher training sessions as well as ad hoc support. Establish and track contracting KPIs, dashboards, and metrics to provide visibility into system performance and contracting volume. Partner with the IT Administrator to drive continuous contracting process improvements, including identifying opportunities to streamline workflows through automation and the use of Artificial Intelligence tools. Required Qualifications Bachelor’s degree required; JD or Paralegal Certification preferred. 3–5 years of experience in contract management and with CLM system(s). Strong ability to prioritize, independently manage workload, and meet deadlines in a dynamic environment. Exceptional written, verbal, and interpersonal communication skills with a focus on customer service and excellent attention to detail. Proven ability to work with cross-functional teams and build strong internal relationships. Aligned with a patient‑focused mission and able to uphold the highest standards of integrity. Preferred Qualifications Experience with LinkSquares contract lifecycle management system. Demonstrated experience applying AI tools to contract review or process optimization. Industry experience in biotech, pharma, or life sciences. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$124,000&mdash;$140,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Contracts Manager

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Associate Director, Medical Affairs is a strategic, execution‑focused role responsible for translating Medical Affairs strategy into high‑impact operational delivery across multiple therapeutic areas. While the initial priority will be post‑bariatric hypoglycemia, this person will also support efforts in Wolfram syndrome and ALS. They will drive the operationalization of scientific plans, advance launch readiness, and strengthen Medical Affairs excellence in a dynamic, fast‑paced, pre‑launch environment. This is a hands‑on role suited for someone who excels at scientific execution, manages external partners effectively, and leads cross‑functional initiatives through collaboration and influence. A core responsibility of this role is to develop and scale foundational Medical Affairs capabilities—including publication planning, congress strategy and execution, professional society engagement, MLR leadership, insights governance, and field medical enablement. This person will also play a critical role in shaping cross‑functional strategy by ensuring scientific rigor, translating insights into action, and fostering strong alignment across functions. This position is ideal for a scientifically rigorous, highly motivated Medical Affairs leader who thrives in a dynamic environment, enjoys taking ownership of high‑visibility work, and is eager to contribute meaningfully to a growing portfolio. As the organization evolves, the role offers clear opportunities to expand scope and advance into broader leadership responsibilities while driving impact for communities with significant unmet needs. Responsibilities Execute end-to-end scientific communications plans across therapeutic areas, including publications, abstracts, congress content, and medical information alignment Lead execution of congress strategy and Medical Affairs presence, ensuring seamless planning, coordination, and delivery of impactful scientific engagement Serve as primary medical reviewer (MLR) for assigned materials; escalate critical items as needed Own the medical insights system and lead monthly insights meetings to inform cross-functional strategy Deliver scientific training modules for the field team and support onboarding of new field team members Ensure field teams receive high-quality, consistent, evidence-based scientific content. Partner with HEOR, Advocacy, Field Medical, R&amp;D, and Commercial teams to ensure alignment and support launch readiness Contribute to the development and continuous improvement of Medical Affairs processes, SOPs, and operating frameworks Required Qualifications Advanced scientific degree (MD, PhD, PharmD or equivalent) 3-5 years of experience in Medical Affairs or related field, with multi-TA exposure preferred Strong organizational and project management skills, with an ability to lead multiple high-priority initiatives in a dynamic, pre-launch environment. Excellent communication, scientific writing, and stakeholder-management skills. Preferred Qualifications Experience leading or contributing to medical insights processes and synthesizing complex information Proven track record in scientific communications, congress activities, and MLR review Experience in rare disease or metabolic/endocrine conditions Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote locatio Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$184,000&mdash;$227,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Medical Affairs

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity As Amylyx Pharmaceuticals continues to evolve and execute against key priorities, we are seeking a highly driven Contract Recruiter to support hiring across Clinical Sciences, R&amp;D, and Technical Operations. This six-month contract role will play a critical part in building talent pipelines and delivering high-quality candidate slates for specialized scientific and technical roles. Responsibilities Serve as a full-cycle recruiting partner focused on sourcing, pipelining, and candidate generation across Clinical Sciences, R&amp;D, and Technical Operations Execute targeted sourcing strategies using LinkedIn Recruiter and other tools to identify and engage passive talent Build and maintain strong pipelines of highly qualified candidates for current and anticipated hiring needs Maintain accurate and up‑to‑date candidate information in our Applicant Tracking System (ATS) to ensure compliance, visibility, and seamless workflow management Track candidate progress through each stage of the hiring process, updating statuses, notes, and interview results in real time Partner closely with hiring managers to understand role requirements, technical capabilities, and candidate profiles Conduct initial candidate outreach, screening, and qualification conversations Deliver well-matched candidate slates aligned with hiring manager expectations Provide consistent updates on pipeline activity, market insights, and sourcing progress Ensure an exceptional candidate experience throughout the recruitment process Collaborate effectively with HR and Talent Acquisition team members to support hiring objectives Support recruiting execution while maintaining speed, quality, and attention to detail Required Qualifications Bachelor’s degree preferred; we value diverse career paths and will gladly consider candidates whose experience, skills, and accomplishments demonstrate success in lieu of formal education Demonstrated recruiting experience supporting Clinical, Scientific, R&amp;D, or Technical Operations roles Strong sourcing capability, particularly with LinkedIn Recruiter Proven ability to identify, engage, and qualify passive candidates Excellent communication and relationship-building skills Ability to operate independently in a fast-paced, evolving environment Strong organizational skills and attention to detail Experience working Applicant Tracking systems, experience with Greenhouse a plus Experience working in biotech, life sciences, or highly specialized technical environments preferred Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings and interviews at our office in Cambridge, MA on a regular, as-needed, basis (on average 2-4 times per month). Preference will be given to candidates who reside in the New England region. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location Compensation The hourly pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Contractor Hourly Compensation Range$100&mdash;$125 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Contract Recruiter – Clinical Sciences, R&D and Technical Operations

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity As Amylyx Pharmaceuticals continues to evolve and execute against key priorities, we are seeking a highly driven Contract Recruiter to support hiring across Commercial and G&amp;A. This six-month contract role will play a critical part in building talent pipelines and delivering high-quality candidate slates for specialized scientific and technical roles. Responsibilities Serve as a full-cycle recruiting partner focused on sourcing, pipelining, and candidate generation across Commercial and G&amp;A Execute targeted sourcing strategies using LinkedIn Recruiter and other tools to identify and engage passive talent Build and maintain strong pipelines of highly qualified candidates for current and anticipated hiring needs Maintain accurate and up‑to‑date candidate information in our Applicant Tracking System (ATS) to ensure compliance, visibility, and seamless workflow management Track candidate progress through each stage of the hiring process, updating statuses, notes, and interview results in real time Partner closely with hiring managers to understand role requirements, technical capabilities, and candidate profiles Conduct initial candidate outreach, screening, and qualification conversations Deliver well-matched candidate slates aligned with hiring manager expectations Provide consistent updates on pipeline activity, market insights, and sourcing progress Ensure an exceptional candidate experience throughout the recruitment process Collaborate effectively with HR and Talent Acquisition team members to support hiring objectives Support recruiting execution while maintaining speed, quality, and attention to detail Required Qualifications Bachelor’s degree preferred; we value diverse career paths and will gladly consider candidates whose experience, skills, and accomplishments demonstrate success in lieu of formal education Demonstrated recruiting experience supporting Clinical, Scientific, R&amp;D, or Technical Operations roles Strong sourcing capability, particularly with LinkedIn Recruiter Proven ability to identify, engage, and qualify passive candidates Excellent communication and relationship-building skills Ability to operate independently in a fast-paced, evolving environment Strong organizational skills and attention to detail Experience working Applicant Tracking systems, experience with Greenhouse a plus Experience working in biotech, life sciences, or highly specialized technical environments preferred Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings and interviews at our office in Cambridge, MA on a regular, as-needed, basis (on average 2-4 times per month). Preference will be given to candidates who reside in the New England region. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location Compensation The hourly pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Contractor Hourly Compensation Range$100&mdash;$125 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Contract Recruiter – Commercial and G&A

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity We are seeking a Contract Compensation Manager to support Amylyx through a period of growth. In this role, you will work closely with Talent Acquisition and the Total Rewards team to benchmark roles, evaluate job descriptions, and ensure competitive, equitable, and consistent offers. This is a unique opportunity to apply deep compensation expertise in a fast-paced environment where high-quality decision-making directly impacts our ability to attract top talent and support the communities we serve. This role is ideal for someone who thrives in a fast‑paced environment, enjoys analytical problem‑solving, and partners seamlessly with Talent Acquisition to ensure consistent, high‑quality offer outcomes. Responsibilities Core Focus Areas Partner closely with hiring managers and Talent Acquisition to benchmark new and evolving roles, validate leveling, and ensure job descriptions align with internal frameworks and external market data Provide compensation insights to TA and hiring managers, helping shape hiring strategies for new or hard‑to‑fill roles Advise TA on offer negotiation strategies to ensure consistency, fairness, and timely closings Partner with HR colleagues to align new roles to our leveling framework and ensure consistency across functions Support offer development, ensuring all offers reflect our compensation philosophy, internal equity, and compliance with pay standards Conduct market pricing using Radford and other survey data; prepare clear, well‑supported recommendations Maintain internal equity across teams and functions, analyzing trends, compression risks, and leveling consistency Operational &amp; Analytical Support Build and maintain Excel-based analytical tools to support fast, accurate offer modeling. Perform ad-hoc compensation analyses to support business decisions, including pay ranges, job mapping, and compensation health metrics Maintain a library of market data, benchmarks, and survey inputs to support hiring needs. Enhance existing tools, templates, and job benchmarking resources to enable TA to work more efficiently Develop quick‑reference guides or job-matching tools to speed up pricing and leveling Cross‑Functional Collaboration Serve as a subject matter expert on compensation practices for TA, HRBPs, and business leaders. Advise on compensation process improvements, including opportunities to streamline offer workflows, enhance data quality, and improve stakeholder experience. Contribute to broader Total Rewards and HR projects as needed Required Qualifications 6+ years of compensation experience in biotech, pharma, high-growth tech or similar dynamic environments Preference for candidates with experience in pre‑commercial biotech, ideally with exposure to scaling compensation practices in advance of commercial launch Prior experience with Radford/AON and other relevant market surveys Exceptional analytical skills and expert‑level Excel proficiency. Strong attention to detail, with a commitment to producing accurate and thorough, market‑aligned analyses Ability to manage sensitive information with the highest level of confidentiality Highly resourceful, organized, and comfortable working in a fast‑paced, ambiguous environment Strong communication skills with the ability to translate complex data into clear guidance for non‑comp stakeholders Experience with equity analysis and benefits is a plus Work Location and Condition At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.&nbsp; Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The hourly pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Contractor Hourly Compensation Range$80&mdash;$100 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Compensation Manager (Contractor)

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Amylyx is seeking a highly motivated Associate Program Manager to provide hands-on project coordination support for the preparation of clinical areas of a New Drug Application (NDA) for a Phase 3 program. This individual will work in the Program Management department, reporting to the Director, Program Management.&nbsp; This is an exciting interdisciplinary role for a qualified and highly motivated individual. Responsibilities Assisting in the management of cross-functional sub teams to facilitate timely planning, execution, tracking, and completion of NDA-related clinical deliverables. Sub-teams may include individuals from the following functional areas: clinical development, clinical operations, safety, medical affairs, biometrics, regulatory, program management, etc.&nbsp; Setting up meetings, drafting agendas and detailed minutes, and tracking actions through completion. Assisting in the identification of issues impacting plan execution and working with the team to identify risks and develop mitigation strategies Ensuring effective and timely communication to sub-team members regarding activity status, key milestones, identified risks and resource allocation Required Qualifications MS or BS Degree in life sciences, healthcare, or related field. Minimum of 3 years experience in pharmaceutical or biotechnology drug development with at least 1 year in a project/program management role. Experience with clinical development phases is mandatory. Experience in project management supporting cross-functional teams with strong organizational skills. Proficiency in project management software and tools (e.g. Smartsheet, SharePoint or similar). Excellent written and verbal communication Exceptional interpersonal skills and time management skills. Extremely well-organized with the ability to manage highly detailed workflows. Proactive and self-motivated with expertise in both planning and implementation. Enthusiasm for working in a fast-paced dynamic environment with a sense of urgency. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The hourly pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Contractor Hourly Compensation Range$48&mdash;$55 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Program Manager (Contract)

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Clinical Data Management team at Amylyx Pharmaceuticals is seeking an Associate Director, Clinical Data Programmer. This individual will work collaboratively cross-functionally to provide hands-on data management support, programming support and technical leadership to develop, maintain, validate the clinical database, and run computer programs that access, visualize, and report clinical trial data, in accordance with various clinical plans, ICH guidelines, and applicable regulatory requirements. As an Associate Director of Clinical Data Programming, you will be required to program in the appropriate languages to create both textual and graphic displays that facilitate data cleaning and review. Responsibilities Lead the study-specific design, development, and validation of study clinical data capture systems, ensuring data integrity, CDISC compliance and CRO oversight. Supports leading data management activities (i.e. DMP creation, CRF creation, edit checks creation, database lock), assisting with database setup, conduct and closeout phases. Performs UAT of systems and ensures appropriate plans and documentation are in place. Leads the development of SAS macros, data listings, summary tables and visualizations for supporting periodic and ad hoc data review. Manages external vendor compliance and quality checks. Supports Clinical Operations, Biostatistics and Data Management by providing data insight and solving technical data challenges. Ensures databases adherences to SOPs, 21CRF Part 11, ICH-GCP and CDISC Standards (CDASH/SDTM) Acts as a subject matter expert in leading technical initiatives and data management Required Qualifications Bachelor’s degree or higher in Life Science or related discipline 8+ years of experience in clinical data management Extensive experience with clinical data systems (particularly Medidata Rave) and languages like SAS, R or Python Proven experience in clinical trial programming and database management Knowledge of Clinical Data Standards such as CDISC CDASH, and SDTM Provide strong support to Data Management Experience creating advanced interactive data visualizations from raw data using multi-languages and applications such as Using SAS, R, Python, RShiny, Power BI, Tableau, Spotfire etc. Ability to manage multiple projects simultaneously, to manage conflicting priorities, and to be flexible when priorities change. Excellent written and verbal communication skills and organizational and documentation skills. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communicate via video conference, etc.) at your remote locatio Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$183,000&mdash;$206,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Clinical Data Programmer

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Associate Director, Computer System Validation (CSV) &amp; Quality Compliance provides enterprise‑level leadership, strategic direction, and governance for the validation, lifecycle management, and continuous compliance of GxP‑relevant computerized systems, with a strong emphasis on the Veeva Quality Suite. This role ensures that digital quality solutions and supporting systems meet global regulatory requirements (FDA, EMA, ICH, GAMP 5), maintain data integrity, and enable a sustainable, inspection‑ready state across the organization. This person will partner closely with Quality, IT, Regulatory, Clinical, and business process owners to define system requirements, lead new system implementations and major enhancements, and drive harmonized, risk‑based validation practices. This role also oversees quality compliance processes such as Change Control, Deviations, CAPA, and continuous improvement, ensuring timely closure, trend analysis, and effective governance through leadership of key forums including Quality Management Review and cross‑functional compliance meetings. Responsibilities Strategic Leadership &amp; Governance Develop, evolve, and steward the corporate CSV/CSA strategy, ensuring alignment with enterprise digital strategy and Quality Management System (QMS) objectives. Serve as the senior Quality authority for computerized systems validation, data integrity, and electronic system compliance. Oversee enterprise-wide governance programs, ensuring standardized, risk‑based approaches to system implementation and maintenance. Provide strategic guidance to senior leadership regarding system performance, risks, and compliance maturity. Computer System Validation &amp; Lifecycle Oversight Lead planning, execution, review, and approval of validation deliverables across GxP systems. Oversee system lifecycle activities including impact assessments, change management, periodic reviews, audit trails, user access reviews, and system retirement. Promote and reinforce CSA‑aligned, risk‑based validation practices to streamline compliance and maximize efficiency. Ensure documentation quality and consistent application of SDLC principles across projects. Veeva Systems Expertise &amp; Optimization Serve as the Quality SME for the Veeva Quality Suite, providing expert guidance on configuration, workflow optimization, and release readiness. Lead implementation, enhancement, and optimization of Veeva Vault modules and cross‑functional integrations. Drive automation and digitization initiatives that improve usability, compliance, and system performance. Partner with IT and Veeva administrators to maintain robust, compliant change control processes. Quality &amp; Regulatory Compliance Ensure all computerized systems maintain compliance with 21 CFR Part 11, EU Annex 11, GxP principles, and global data integrity expectations. Author, revise, and own Quality System policies and procedures related to electronic systems and validation. Represent Quality during internal audits, external regulatory inspections, and vendor assessments. Lead timely remediation, effectiveness checks, and continuous improvement initiatives. Provide oversight and trending for Quality Events related to system performance or compliance. Required Qualifications Bachelor’s degree in a relevant scientific or technical discipline. 8+ years of experience in the life sciences industry with strong GxP system experience. Extensive leadership experience in cross functional implementation and validation of GxP computerized systems. Deep expertise with Veeva Vault Quality Suite (QMS, Docs, Training, etc.). Strong knowledge of global regulatory expectations and data integrity frameworks. Demonstrated ability to lead enterprise programs, influence stakeholders, and drive compliant decision making. Preferred Qualifications Expertise with SaaS/cloud architectures and database compliance expectations. Understanding of clinical data collection technologies and supporting data processes. Familiarity with SDLC, Agile methodologies, CSV vs. CSA principles and automated testing platforms. Experience developing and interpreting Quality metrics such as KPIs and KQIs. Excellent communication skills with the ability to collaborate, negotiate, and influence at all organizational levels. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$170,000&mdash;$191,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Computer System Validation & Quality Compliance

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Director Clinical Science will be a key member of the Clinical Development team with responsibilities to provide scientific support for ongoing activities. This role will report to a Medical Director and will collaborate cross functionally with R&amp;D, program management, clinical operations, biostatistics, and data management. The selected candidate will support and drive key development activities for clinical studies and overall execution of program Clinical Development Plans (CDP). Responsibilities Collaborates with the clinical development team in review, analysis, and interpretation of study results. Provides scientific support on ongoing Phase I to III clinical trials and contributes to the planning and design of upcoming clinical studies. Performs monitoring and review of study data including labs, safety data, and patient eligibility. Authors and/or reviews clinical trial-related documents including protocols, CRF, informed consent, protocol deviations, monitoring plans and regulatory documents, etc. Contributes to regulatory documents including CSRs, Investigator’s Brochures, and Clinical sections of INDs, CTAs. Interacts with external medical/scientific advisors, thought leaders and clinical investigators in the therapeutic areas as well as with internal management and drug development staff to prepare/revise/maintain and efficiently execute the clinical development plan. Required Qualifications Advanced degree (M.D., Ph.D., Pharm.D., Master’s Degree in Science/Medical-related field). MD, PhD or PharmD with 3+ years Clinical Research, Pharmaceutical, or CRO experience, OR Master’s degree with 8+ years of relevant experience. Knowledge of Phase 1-3 drug development. Knowledge of clinical trial implementation and sponsor/site interactions for clinical trials. Prior experience working within neurology or neurodegenerative indications. Well-versed in relevant applications of GCP (Good Clinical Practice), ICH, FDA, EMEA and other relevant guidelines and regulations. Strong, collaborative team-player. Excellent attention to detail and communication skills. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$173,000&mdash;$195,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Clinical Sciences

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Position Reporting to our Co-CEO’s, the SVP of Program Leadership &amp; Development will drive the advancement of our clinical-stage pipeline. This individual will be responsible for end-to-end leadership of one or more key development programs translating scientific innovation into clinical, regulatory, and commercial success. The SVP of Program Leadership &amp; Development will play a critical role in shaping program strategy, guiding cross-functional execution, and maximizing asset value from early development through late-stage trials and potential regulatory approval. This role will serve as a core member of the Senior Leadership Team, partnering closely with Clinical Operations, Medical, Regulatory, Biometrics, CMC, Commercial and other functional leaders to drive the successful execution of Amylyx’s development portfolio. In a lean and evolving biotech environment, this individual will operate both as an enterprise leader and a hands-on program leader, directly supporting key assets while building a scalable program leadership organization over time. The Opportunity This is a unique opportunity to shape and define how program leadership is executed within a growing biotech organization at a critical inflection point. Build a New Function from the Ground Up - design and implement a modern program leadership model, including the evolution from traditional program management to a strategic Program Lead and Program Manager structure. Operate as a True Peer to Clinical and Medical Leadership - serve as an equal partner to senior leaders across Clinical Operations, Medical, and Regulatory, helping shape asset strategy and execution. Drive Impact Across the Full Development Lifecycle - lead programs spanning early-phase IND-enabling work through Phase 3 and potential NDA submission, with direct impact on key value-driving milestones. Balance Strategy and Execution in a Lean Environment - play a dual role as both a strategic leader and hands-on program leader, directly influencing outcomes while building for future scale. Shape Organizational Culture and Ways of Working - establish a highly collaborative, accountable, and transparent operating model that strengthens alignment across functions and reduces organizational friction. Scale with the Portfolio - build and develop a high-performing team over time, aligned to the growth of the pipeline and key clinical milestones. Responsibilities Strategic Program Leadership Partner with Clinical Operations and Medical leadership to define and execute development strategies and plans across programs Drive program-level decision-making, including risk assessment, trade-offs, and prioritization Ensure alignment between asset strategy, clinical execution, and regulatory pathways Present program updates, risks, and opportunities to Executive Leadership and Board of Directors Cross-Functional Integration &amp; Alignment Serve as the central integrator across Medical, Clinical Operations, Regulatory, Biometrics, CMC, Commercial and other key functions Drive clarity of roles, decision-making, and accountability across program teams Proactively identify and resolve cross-functional misalignment, gaps, and competing priorities Hands-On Program Execution Directly serve as Program Lead for one or more key assets, particularly in the early phase of the role Lead cross-functional team meetings, execution planning, and milestone delivery Translate strategic objectives into clear, aligned execution plans Build &amp; Scale Program Leadership Design and implement a program leadership model, including Program Leads and Program Managers Hire, develop, and lead program leadership talent over time as the organization grows Establish best practices, governance frameworks, and ways of working that enable scalability Portfolio &amp; Executive Contribution Contribute to portfolio prioritization, resource allocation, and strategic planning discussions at the leadership level Provide clear, actionable insights and recommendations to executive leadership Support the evolution of Amylyx’s development organization as it scales toward key clinical and regulatory milestones Required Qualifications Advanced degree (PhD, MD, PharmD, or MD) in a relevant scientific discipline preferred; equivalent experience in drug development and program leadership will also be considered 20+ years of experience in the pharmaceutical or biotechnology industry, including significant experience leading cross-functional drug development programs Lead integrated clinical development plans (CDPs) Overseen protocol design, endpoints, and trial execution Demonstrated success in regulatory interactions (FDA, EMA) Significant experience leading cross-functional drug development programs, ideally spanning early development through late-stage clinical and/or regulatory milestones Demonstrated success in regulatory interactions (FDA, EMA) Prior experience serving as a Program Lead, Development Team Leader (DTL), Asset Team Lead or equivalent role, with accountability for cross-functional program execution Demonstrated ability to partner with Clinical Operations, Medical, and Regulatory leaders as a peer, influencing strategy and execution Experience operating in a biotech or similarly lean, fast-paced environment, with comfort navigating ambiguity and evolving priorities Proven track record of building or scaling teams and/or functions within a matrixed organization Strong leadership and collaboration skills, with the ability to align diverse stakeholders and drive decision-making in complex environments Hands-on, execution-oriented leadership style, with willingness to engage directly in program delivery when needed Excellent communication and interpersonal skills, with the ability to bridge scientific, clinical, and business perspectives Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. &nbsp;Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$373,000&mdash;$420,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Vice President, Program Leadership & Development

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Senior Director, Trade &amp; Channel Operations will be responsible for building Amylyx’s U.S. distribution and channel model from the ground up in preparation for a future commercial launch of our lead product candidate. This individual will architect the distribution strategy, create the operational infrastructure necessary for launch, and partner cross functionally to ensure Amylyx is fully prepared to commercialize with excellence. As a key member of the Market Access team, this role will influence launch readiness, customer service delivery, and ongoing performance across distribution partners. Responsibilities Design and build Amylyx’s U.S. distribution model across specialty pharmacy, specialty distributor, and 3PL channels to support product launch Lead contracting strategy for specialty pharmacies and distributors, including negotiating distribution and service agreements, fee schedules, data requirements, and service levels Integrate distribution channels with service programs and field initiatives to enable a seamless customer experience Collaborate with Supply Chain and Finance to support 3PL operations, including order‑to‑cash processes, inventory management, data exchange, shipping, returns, and chargeback management Establish and manage noncommercial and free‑goods pharmacy operations Forecast and model channel performance, assess specialty pharmacy throughput, and provide recommendations to ensure timely, reliable patient access Develop distribution analytics including inventory visibility, service metrics, dispense data, time to therapy, and partner scorecards; lead specialty pharmacy QBRs Partner cross‑functionally with Supply Chain, Quality, Compliance, Legal, Finance, Patient Services, and Commercial Operations to ensure operational alignment and launch readiness Serve as a senior leader within Market Access, contributing to launch planning, forecasting, patient access workflows, and overall distribution strategy Continuously optimize post‑launch distribution operations by driving root‑cause remediation, vendor KPI management, and process improvements informed by field and service feedback. &nbsp; Required Qualifications Bachelor’s degree required 12+ years of experience in biopharmaceutical trade and distribution, including leadership of specialty pharmacy and distributor channel networks Prior product launch experience in the US market Experience designing and implementing channel strategies for product launches Proven ability to assess, manage, and influence channel partner performance to contractual expectations Hands‑on experience with 3PL operations, serialization, state licensing, and compliant distribution processes Demonstrated strength in contract negotiation, vendor management, and commercial channel operations Deep understanding of payer reimbursement, hub/patient support integration, channel economics, and order‑to‑cash workflows Proven leadership experience, including managing large pharmaceutical vendors, with demonstrated people management skills Excellent communication, vendor management, analytical, and project execution capabilities &nbsp; Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$255,000&mdash;$287,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Trade & Channel Operations

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity We are seeking a Senior Director, Market Access Strategy to support a new product launch. This leader will own the creation of the payer value proposition, lead pricing strategy for launch, and prepare effective communications across payer, distribution channel, field access, and patient support teams. As a key member of the Market Access leadership team, you will work cross functionally to drive strategies for all market access functions, oversee a post-launch marketing and pricing operations team, and effectively manage any vendors that support these initiatives. Responsibilities Shape and lead the payer value story for Amylyx’s first launch product, translating clinical, economic, and real‑world evidence into a differentiated, evidence‑based value proposition that supports optimal access and reimbursement. Drive payer marketing and launch execution in close partnership with Medical Affairs, including development of PIE content, AMCP dossiers, and comprehensive launch education materials. Partner with Medical and Access leadership to define payer evidence requirements, identify data gaps, and execute strategies to address unmet needs across pre‑ and post‑launch phases. Develop and deploy access tools and communications that enable field access teams, patient support programs, and pharmacy partners to execute effectively and consistently. Establish a cross‑functional performance feedback loop across payer, field access, pharmacy, and services teams to rapidly identify access barriers and drive issue resolution. Build and oversee post‑launch pricing operations, including list price governance, price change management, pricing committee leadership, and close collaboration with Finance on gross‑to‑net management. Lead agencies and vendors, monitor payer and policy dynamics, and represent market access strategies including performance, risks, and opportunities—to internal stakeholders and senior leadership. Required Qualifications Bachelor’s degree required 12+ years of experience in pharmaceutical market access, pricing, reimbursement strategy, and payer marketing Prior launch experience in US market Deep expertise in the U.S. payer, reimbursement, coverage, and coding landscape for specialty products under the pharmacy benefit Proven experience developing payer value propositions and payer‑facing materials Strong analytical skills using market access data sources (e.g., HUB, specialty pharmacy, and claims data) People leadership experience, including hiring, coaching, and developing teams Demonstrated experience with pricing strategy, contract modeling, and gross‑to‑net management Strong vendor management and contracting experience across agencies, consultants, analytics partners, and pricing operations vendors &nbsp; Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$263,000&mdash;$296,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Market Access  Strategy

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Senior Director of Patient Services will play a critical role in shaping how Amylyx supports patients throughout their treatment journey. This leader will design, build, and launch a best-in-class patient support program for our lead product candidate, ensuring that it reflects a commitment to supporting patient access, community education, and operational excellence. This individual will bring strategic vision and hands on leadership to create an integrated support program—from access and reimbursement solutions to patient education and continued on-treatment support. As a key leader in the commercial organization, this individual will partner with colleagues across market access, sales, and marketing, as well as cross functionally, to ensure a seamless and high impact customer experience that helps people start and continue treatment. This is a unique opportunity to define a foundational capability at Amylyx and set a new standard for patient access support. Responsibilities Program Design Design a comprehensive, patient‑centered services model tailored to the unique needs of the communities we serve Define the strategic framework, service offerings, operational workflows, and end‑to‑end experience for patients, caregivers, and providers, ensuring alignment with the current market access landscape across reimbursement, technology, and delivery models Optimize the program by determining the appropriate balance of insourced versus outsourced services and planning for program evolution over time &nbsp;Operations Leadership Lead end‑to‑end patient support operations, including financial assistance, benefits verification, case management, adherence, nursing, and injection training Build, hire, and lead high‑performing internal and field‑based patient access and service operations teams Evaluate, contract, and manage third‑party service providers, ensuring strong governance, performance accountability, and alignment with business objectives Establish compliant oversight across hub services and all patient‑facing operations in close partnership with Legal, Compliance, and Medical Affairs Define KPIs, dashboards, and feedback loops to drive performance, transparency, and continuous improvement across service operations Serve as the operational lead for launch readiness and ongoing execution by identifying access barriers, leading cross‑functional issue resolution, and aligning with Commercial, Market Access, Sales, Medical Affairs, IT, and National Accounts teams &nbsp; Required Qualifications Bachelor’s degree required, advanced degree in a related health or business field preferred 12+ years of experience in biopharmaceutical patient support services, including product launch and rare disease product access Proven track record designing, launching, and managing hub services, reimbursement support, and financial assistance programs Expertise in U.S. payer specialty drug coverage, reimbursement mechanics, and specialty pharmacy operations Proficiency in analytics and reporting for service programs and pharmacy data Knowledge of compliance and regulatory requirements for patient support programs Ability to communicate program objectives, launch plans, and performance effectively to internal stakeholders Proven people management experience, including hiring, coaching, and developing teams Demonstrated leadership of cross‑functional teams in fast‑paced, launch‑focused environments An unwavering dedication to patient access and empowering the teams responsible for delivering it &nbsp; Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$253,000&mdash;$285,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Patient Services

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Associate Director, HCP Marketing will be a critical member of the Marketing team and will be responsible for leading the healthcare professional (HCP) engagement strategy to support the launch of avexitide for post-bariatric hypoglycemia (PBH). This role will focus on identifying, understanding and engaging key HCP segments, including thought leaders and early adopters, to build awareness of PBH and the role of avexitide in its treatment. This individual will partner closely with the sales force and field-facing teams, including Thought Leader Liaisons (TLLs), to ensure aligned, educational, and impactful engagement with the HCP community. Through the development of targeted promotional strategies and educational initiatives, this individual will help shape the HCP understanding of PBH, drive informed clinical dialogue and support successful product adoption at launch. This is a unique opportunity for a strategic, collaborative, and results-oriented HCP marketer to build a high-impact engagement platform in a complex and underserved therapeutic area. &nbsp; Responsibilities Lead the development and execution of the HCP marketing strategy to support the launch of avexitide in the U.S., with a focus on raising awareness and understanding of post-bariatric hypoglycemia (PBH) among key clinical audiences Identify and prioritize HCP targets, including early adopters, influencers, and thought leaders, to inform segmentation, messaging, engagement strategies, and opportunities for advisory boards and speaker programs Develop and deploy unbranded and branded educational materials and tools, speaker content and engagement tools across personal and non-personal channels to support HCP understanding of PBH and avexitide Partner closely with the sales force and TLLs to align on field strategies, deliver compelling resources and ensure consistent and aligned execution across U.S. regions Create field-facing resources, engagement tools and trainings (e.g., leave-behinds, visual aids, digital content, trainings, etc.) that support effective HCP conversations and reinforce key clinical messages Lead the planning and execution of HCP-focused conference and symposium activities, including booth presence, branded and unbranded materials, and sponsored programs in collaboration with cross-functional teams Drive the planning and execution of advisory boards and speaker program activities, including associated content development Oversee tracking of budget accruals, forecasts, and actuals, and ensure successful and timely completion of projects within budget Manage the end-to-end process for the development, review / approval, printing, and fulfillment of all HCP-facing materials Help manage external agencies and partners to ensure timely, high-quality deliverables that meet agreed-upon objectives, key performance indicators (KPIs), timelines, and budgets Ensure compliance with all Medical, Legal, and Regulatory (MLR) requirements in the development and deployment of HCP-facing materials Leverage customer and market insights, claims, and performance data to develop insight-driven marketing strategy and content, continuously optimize programs and identify opportunities for innovation Required Qualifications Bachelor’s degree required 8+ years of pharmaceutical or biotech experience, with at least 3 years focused on HCP Marketing Proven success in developing and executing HCP engagement strategies Experience supporting field teams and partnering with Sales, Field Marketing and Thought Leader Liaison to drive brand messaging and education Demonstrated ability to translate complex clinical information into clear, compelling promotional messaging for HCP audiences Strong project management and organizational skills, with the ability to lead multiple high-priority initiatives simultaneously Effectively managing external partners, agencies and budgets Navigate Medical, Legal, and Regulatory (MLR) review and approval processes Strong communication, strategic thinking, relationship-building skills, and a results-oriented mindset Preferred Requirements Advanced degree; PharmD preferred Experience in rare disease or product launch environments Familiarity in digital HCP engagement, thought leader strategy and clinically complex therapeutic areas Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$193,000&mdash;$217,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, HCP Marketing

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Senior Director, Market Insights is a highly visible, enterprise-level leadership role responsible for defining and driving the end-to-end insights strategy to support U.S. commercialization and global expansion. The Senior Director will serve as the strategic owner of the insights function, ensuring that market intelligence, analytics, and evidence generation are fully integrated into corporate decision-making across the product lifecycle. Reporting into the Vice President, Commercial Operations, the Senior Director will act as a key advisor to commercial and executive leadership, shaping commercial strategy through forward-looking insights that inform launch readiness, lifecycle management and portfolio prioritization. This role requires the ability to operate at both a strategy and operational level, building scalable capabilities and frameworks to support a multi-asset, multi-market organization. Responsibilities Define and own the enterprise-wide market insights strategy, aligning U.S. and ex-U.S. perspectives to support global commercialization and long-term portfolio growth, ensuring readiness across multiple markets and stakeholder groups Lead and execute market research projects influencing key decisions related to product launch strategy, lifecycle planning, new product planning, and as necessary, key market access strategies; ensure project deliverables are actionable, archived, and accessible Lead cross-functional integration of insight, ensuring alignment across Marketing, Medical, Market Access, Regulatory, R&amp;D, and Executive Leadership to support decision-making Build and scale the market insight’s function, including defining operating models, processes, tools, and governance to support increasing organizational complexity Oversee and evolve global competitive intelligence strategy, ensuring proactive identification and ongoing communication of market shifts, competitive threats, and strategic opportunities Partner with Business Development (BD) colleagues to rapidly build market assessments, competitive landscape modeling, value creation theses, and financial modeling to facilitate executive decision-making Drive development of advanced analytics capabilities, including integration of primary research, real-world data, and secondary data sources into a cohesive insight ecosystem Establish KPIs and measurement frameworks (customer engagement, brand tracking, etc.) to evaluate commercial effectiveness and inform ongoing strategic adjustments Lead external partnerships and vendor strategy, including selection, governance, and optimization of research and analytics partners Develop and mentor future capabilities, including team build-out as the organization scales Lead insights efforts with a focus on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS) Required Qualifications Bachelor’s degree required; advanced degree (PhD, MD, PharmD, or MBA) preferred 12+years of experience in pharmaceutical or biotech market research, insights, or analytics, with increasing levels of responsibility Proven experience generating insights across the product lifecycle, including early-stage development, launch, and post-launch optimization Demonstrated expertise in competitive intelligence, including conference coverage and strategic synthesis of competitor activity Strong understanding of global market dynamics, including U.S. and ex-U.S. commercialization considerations Experience building or scaling capabilities, functions, or operating models Advanced analytical and strategic thinking skills, with the ability to translate complex data into actionable, enterprise-level decisions Exceptional communication and executive presence Experience in endocrinology is preferred Strong vendor management, budget oversight, and project management skills High degree of initiative, curiosity, and comfort with ambiguity in a fast-paced, mission-driven environment Work Location and Conditions ** Preference will be given to candidates residing in the Boston area or elsewhere on the East Coast. At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$257,000&mdash;$289,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, Market Insights

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Reporting to the SVP, Human Resources and Talent Acquisition, the Senior Director, HR Business Partner (HRBP) for the Commercial Organization is a strategic leadership role responsible for partnering closely with the Chief Commercial Officer (CCO) and Commercial Leadership Team to build, scale, and optimize a high-performing commercial function. This individual will serve as a trusted advisor, aligning people strategies with business objectives to support the successful transition to and execution of commercialization, including both corporate and field-based teams. This role will be hired in advance of commercial scale-up and top-line data, within a lean and evolving organization. While the primary focus is supporting the Commercial function, the Senior Director will initially operate as a broad HR Business Partner across the enterprise, flexing support across Clinical, Technical Operations, and G&amp;A as needed. This role requires comfort operating in a highly dynamic, resource-constrained environment, with the ability to balance strategic leadership with hands-on execution.&nbsp; As the organization evolves through key clinical and commercial milestones, this role is expected to scale in scope and impact, transitioning from a broad, hands-on HR Business Partner role to a more dedicated commercial HR leadership position. Responsibilities Strategic Partnership &amp; Leadership Serve as the primary HR partner to the CCO and Commercial Leadership Team, providing strategic counsel on organizational effectiveness, talent, and culture Contribute to the development and execution of the commercial strategy by aligning HR initiatives with business priorities Act as a thought partner on scaling the organization from pre-commercial to fully commercial operations Organizational Design &amp; Build-Out Lead the design and implementation of the commercial organizational structure, including headquarters and field-based teams (e.g., sales, market access, patient services, marketing) Support workforce planning aligned to launch readiness, market expansion, and long-term growth Drive role clarity, spans and layers optimization, and organizational efficiency Talent Strategy &amp; Development Partner with leadership to attract, retain, and develop top commercial talent, including building leadership capability across the organization Guide succession planning and leadership development initiatives Coach senior leaders on performance management, team effectiveness, and change leadership Performance &amp; Compensation Collaborate with Total Rewards to design and implement competitive compensation and incentive programs aligned with commercial goals (including sales incentives and LTI structures) Support performance management processes aligned to corporate and commercial objectives, ensuring the foundational elements of a high-performing commercial culture are in place, including clear goal-setting, accountability, and differentiated performance outcomes Culture &amp; Employee Experience Champion a high-performance, patient-centric culture aligned with company values Lead change management initiatives to support rapid growth and evolving business needs Ensure strong employee engagement across both corporate and geographically dispersed field teams Employee Relations &amp; Compliance Provide guidance on complex employee relations matters with sound judgment and business alignment Ensure compliance with all applicable employment laws and company policies, particularly within a distributed field organization Required Qualifications Bachelor’s degree in Human Resources, Business Administration, or related field required; Master’s degree (MBA, MS, or equivalent) strongly preferred Minimum of 15+ years of progressive HR experience, including significant HR Business Partner leadership roles Demonstrated experience partnering with a Chief Commercial Officer and senior commercial leadership in building and scaling commercial organizations while being willing to operate beyond a single function and support enterprise-wide needs Proven success supporting both corporate and field-based teams, including sales organizations Experience within biotechnology or pharmaceutical industry required;&nbsp;rare disease experience strongly preferred Comfortable navigating ambiguity and shifting priorities, with a willingness to take on both strategic and hands-on HR responsibilities across multiple functions Deep expertise in organizational design, talent management, and change leadership in high-growth environments Strong business acumen with the ability to translate strategy into actionable HR initiatives Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.&nbsp; Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$243,000&mdash;$273,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, HRBP - Commercial

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity This Real World Evidence (RWE)/Health Economics (HEOR) Contractor role supports the RWE/HEOR Senior Director in leading RWE execution for pipeline assets. The role is fun and flexible with a mix of both study execution and data analytics. This person will be accountable for developing and delivering components of the evidence generation plan (including RWE and economic value evidence), and driving high-quality deliverables that inform internal decision-making during product development, pre-launch readiness, and lifecycle planning. The role is anchored to 1–2 priority pipeline assets/indications. This is a remote role based with flexible hours. We are currently seeking an individual with 20-30 hours of weekly availability with potential to increase hours in late 2026/2027. Responsibilities Evidence strategy and planning: Maintain US RWE &amp; HEOR plans for 1–2 priority pipeline assets/indications, aligned to US medical, payer, and access needs; translate strategy into actionable workplans, timelines, and resourcing proposals. Study leadership (RWE/HEOR): Own day-to-day leadership for assigned real-world evidence and health outcomes studies (e.g., real-world evidence studies, cost-effectiveness/budget impact analyses, burden of illness, treatment patterns, patient-focused outcomes) including&nbsp;design and execution in partnership with internal functions and external vendors. Scientific communication and quality: Draft/review project specifications, protocols, statistical analysis plans, study reports, abstracts, posters, and manuscripts; ensure adherence to SOPs and high scientific/operational quality. Analytic execution and statistics: Execute ad hoc analyses in clinical trial, claims and PCOR data as needed for ad hoc and protocol/SAP driven analyses. This may include feasibility or full protocol execution. Governance, compliance, and capability building: Complete required training, adhere to company/department SOPs, and contribute to continuous improvement of processes that enable efficient planning, execution, and dissemination of RWE &amp; HEOR deliverables. Required Qualifications Master’s degree or PhD in epidemiology, health economics and outcomes research, public health, biostatistics, or related discipline. At least 1+ years of experience in the pharmaceutical industry and/or managed care, hospital, academic, or healthcare consulting environment with exposure to HEOR/RWE strategy and application Proficiency with SAS and/or R for statistical programming. Preference for experience in clinical trials OR claims data. Expertise in RWE and study designs/methods evidenced by publications and/or contributing to study concept sheets and protocols, reviewing/authoring key sections of statistical analysis plans and study reports, and ensuring publication/disclosure readiness in accordance with ICJME criteria Strong communication and presentation skills, demonstrated by developing and presenting clear, decision-oriented materials (e.g., evidence strategy slides, executive readouts) and summarizing outcomes/next steps for senior audiences Preferred Qualifications Demonstrated success developing and executing health outcomes research plans and delivering high-quality data generation outputs. Experience managing real-world data sources and vendors (e.g., claims, EHR, registries) and translating findings into actionable insights and value messages. Demonstrated ability to influence without authority in a matrix environment, evidenced by aligning cross-functional stakeholders on objectives/trade-offs, documenting decisions, and driving actions to closure. Experience in PCOR implementation and validation Work Location and Condition At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location Compensation The hourly pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Contractor Hourly Compensation Range$55&mdash;$90 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Real World Evidence/HEOR Contractor

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The SVP of Sales will play a critical leadership role in building and executing the commercial strategy for a pre‑commercial biotechnology company preparing for its first product launch. This individual will be responsible for designing and implementing the Go‑To‑Market (GTM) strategy, recruiting and developing a high‑performing sales organization, establishing strong relationships with Key Opinion Leaders (KOLs), ensuring full sales force readiness ahead of launch and driving performance. The ideal candidate combines strategic vision with hands‑on execution experience in specialty pharma or biotech launches and thrives in a fast‑paced, build‑from‑scratch environment. Responsibilities Enterprise Commercial Leadership Shape overall U.S. commercial strategy in partnership with the Chief Commercial Officer, including long-range planning beyond initial launch. Play a key role in portfolio planning and lifecycle strategy, including future indications and pipeline assets. Contribute to Board-level discussions on commercial readiness, launch strategy, and performance. Partner with Finance and Executive Leadership on revenue planning, scenario modeling, and investment decisions. Go‑To‑Market Strategy &amp; Execution Design and implement a comprehensive Go‑To‑Market plan, aligned with brand strategy, market access, patient services, medical affairs, and marketing capabilities. Translate clinical value propositions into clear commercial messaging and field execution plans. Partner cross‑functionally with Marketing, Medical Affairs, Market Access, and Operations to ensure launch readiness. Define sales territory strategy, targeting, segmentation, and deployment models. Establish key performance indicators (KPIs), sales forecasting processes, and performance management frameworks. Sales Organization Build‑Out Recruit, hire, and onboard a high‑caliber field sales team, including regional leadership. Design and evolve a scalable sales organization architecture, with the ability to expand across multiple teams, regions, and future product lines. Develop a multi-year sales capability roadmap, including leadership bench building and succession planning. Build and lead second-line leadership (RSDs/Area Directors) as the organization scales. Develop and implement training programs to prepare the team for launch, including disease state education, product knowledge, and selling skills. Create a performance‑driven culture focused on accountability, collaboration, and continuous improvement. Launch Preparation &amp; Excellence Lead all sales‑related launch readiness activities, ensuring the field team is fully prepared for pre-launch and launch execution. Oversee development and deployment of sales tools, CRM processes, call planning, incentive compensation and reporting infrastructure. Ensure compliance with all regulatory, legal, and ethical standards. KOL &amp; External Engagement Engage with Key Opinion Leaders (KOLs) and other key stakeholders to support scientific exchange and commercial insight gathering. Partner with Medical Affairs to ensure appropriate, compliant KOL interactions. Provide field‑based insights to inform brand strategy, messaging refinement, and lifecycle planning. Leadership &amp; Stakeholder Management Serve as a key member of the commercial leadership team, contributing to overall business strategy. Present sales strategy, progress, and performance updates to executive leadership and the Board as required. Mentor and develop future sales leaders within the organization. Required Qualifications Bachelor’s degree required; advanced degree (MBA, MS, PhD) preferred. 15+ years of progressive sales leadership experience in biotech or pharmaceutical organizations. Demonstrated success leading early product launches, ideally in specialty or rare disease. Proven experience building and scaling sales teams in pre‑commercial or early‑stage environments. Strong understanding of the U.S. healthcare landscape, including KOL engagement, payer dynamics, and integrated launch planning. Experience working cross‑functionally in highly matrixed organizations. Ability to operate both strategically and tactically in a resource‑constrained environment. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$353,000&mdash;$397,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Vice President, Sales

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity Join Amylyx at a pivotal moment of growth and visibility as our Director, Investor Relations—a high-impact role at the center of our corporate story, strategy, and market presence. In this position, you’ll work side-by-side with the VP of Investor Relations &amp; Communications and partner closely with our senior leadership team—including our co-CEOs, CFO, CMO, and CCO—to shape how the investment community understands and values our mission. You’ll serve as a strategic advisor and storyteller, helping to translate complex science and financial performance into a clear, compelling narrative that resonates with investors and analysts. You’ll play a key role in strengthening our investor engagement program, building meaningful relationships, and influencing how Amylyx is perceived in a dynamic and evolving healthcare landscape. Responsibilities Support the development and execution of investor relations plans and initiatives aligned with corporate goals during a period of dynamic growth, while helping to define and drive a forward-looking 12–24 month IR strategy in partnership with senior leadership and the Board, ensuring alignment with long-term corporate objectives Engage with the investment community, including healthcare investors and equity research analysts, represent Amylyx at events, and, over time, become a primary relationship owner for select sell-side analysts and new buy-side accounts Write quarterly and annual results communications, including financial results press releases, annual reports, conference call scripts, key messages, Q&amp;As, and other documents to communicate to investor and analyst audiences Partner with colleagues to prepare documents for filings and disclosures to be compliant with SEC regulations (i.e., 8-Ks, 10-Ks, 10-Qs, proxies); in certain circumstances, lead creation of documents for filings Write and create investor-facing materials, including press releases, presentations for investor meetings, key message documents, Q&amp;As, and content for website; lead and make update as appropriate Partner with leadership and other colleagues to ensure consistency of messaging Participate in one-on-one meetings, bus tours, conferences, and non-deal roadshows, and lead follow-up when appropriate Respond to requests for information from external stakeholders, including shareholders, in a timely manner Review and analyze analyst research and models, consensus estimates, and market-related trends impacting valuation and perception; summarize market sentiment on Amylyx and continue to manage consensus Analyze peer companies’ communications, peer sell-side research, industry and communication trends and compile reports for leadership that support investor interactions Partner with Senior IR and Communications Operations Specialist who manages active IR calendar/schedules and prepares background information on investors in advance of meetings; assist with scheduling, preparations, and investor tracking when needed Support the overall Investor Relations function, including assisting with day-to-day needs and long-term special projects Required Qualifications Bachelor’s degree required 10+ years of experience, including 5+ years of experience on commercial biotech or pharma team Background in Investor Relations, Corporate Finance, Equity Research, Buy-Side, or Consulting preferred Strong understanding of financial modeling and how analysts assess company performance and valuation Knowledge of SEC regulations, disclosure requirements, and management of material non-public information Executive presence with the ability to influence and counsel senior leaders Exceptional written, verbal, and presentation skills across diverse internal and external audiences Ability to translate complex scientific, clinical, and financial information into clear, compelling messaging Strong understanding of investor priorities and market expectations Sound judgment and composure in high-pressure environments Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.&nbsp; &nbsp;Preference will be given to candidates who reside in the New England/NYC regions and can be in person on an as needed basis. When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$204,000&mdash;$230,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, Investor Relations

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Process Engineer, Drug Product, will provide technical and GMP support for contract manufacturing organizations (CMOs) responsible for late-stage clinical and commercial drug product supply. This role serves as the primary technical subject matter expert (SME) for aseptic processing including sterile filtration, formulation, filling, and container closure systems. The role will establish and maintain strong, trust-based relationships with CMO technical and quality teams to ensure reliable, compliant, and efficient manufacturing of aseptically filled drug products. Operating as a highly agile technical expert, partnering with CMOs and internal stakeholders to ensure robust execution across technology transfer, validation, and lifecycle management. This role reports to the Associate Director, CMC Drug Product. Responsibilities Commercial &amp; Clinical Aseptic Manufacturing Support: Support technical leadership and day‑to‑day aseptic process engineering support for clinical and commercial drug product manufacturing at external CMOs. Serve as the aseptic processing SME during manufacturing operations providing onsite support when required. Lead investigations, perform rigorous root cause analysis and develop scientifically sound CAPAs, ensuring alignment with regulatory expectations and industry best practices. Assess and author technical risk assessments and change controls to support manufacturing changes, investigations, and regulatory filings. Ensure strict compliance with cGMPs, global regulatory requirements, and internal quality systems for aseptic manufacturing. Process Validation &amp; Product Launch Lead and support aseptic drug product technology transfer activities from development to clinical and commercial manufacturing sites. Define and transfer critical process parameters (CPPs), critical quality attributes (CQAs), and in‑process controls for aseptic unit operations. Develop and execute aseptic process validation strategies, including PPQ planning, statistical sampling plans, and acceptance criteria aligned with regulatory guidance. Provide technical authorship and review for regulatory submissions (IND, BLA, NDA, MAA), validation reports, and responses to regulatory agency questions. Support new product introductions and commercial launches by ensuring validated, scalable, and inspection‑ready aseptic processes. Data Analysis &amp; Continued Process Verification Lead continued process verification (CPV) and routine data trending for aseptic unit operations, environmental monitoring, and critical process parameters. Develop and maintain data repositories, dashboards, and meaningful KPIs to assess aseptic process capability and performance. Identify early signals of process drift or increased contamination risk and proactively drive corrective or preventive actions. Prepare and present quarterly CPV summaries and technical assessments for internal management reviews. Continuous Improvement Identify and execute continuous improvement initiatives focused on aseptic process robustness, sterility assurance, capacity, and operational efficiency. Apply Quality by Design (QbD), statistical tools, and risk‑based decision making to optimize aseptic manufacturing processes. Collaborate with CMOs to implement best practices, new technologies, or process enhancements where appropriate Required Qualifications Bachelor’s degree in engineering or related field with 5+ years/ Master’s with 3+ years of relevant experience. Prior experience in aseptic drug product manufacturing for late-stage development/commercial is required. Device experience is a plus. Proficiency in Quality by Design (QbD), Design of Experiments (DoE), statistical process control (SPC), and complex data analysis. Familiarity with modeling and optimization tools (e.g., MATLAB, JMP) is a plus. Detail-oriented with strong problem-solving skills and ability to identify subtle trends in data. Comprehensive understanding of cGMP principles and regulatory requirements, including process, equipment, and facility validation. Excellent communication and teamwork skills. Ability to travel to domestic and international CMOs as needed. Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$131,000&mdash;$147,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Process Engineer

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.The Opportunity The Senior Director, External Manufacturing is a critical leadership role responsible for shaping and executing the external manufacturing strategy across clinical and future commercial programs. This individual will lead a global network of CDMO partners supporting a diverse and growing portfolio spanning peptides, oligonucleotides, and small molecules. As Amylyx advances toward commercialization and expands its global manufacturing footprint, this role will be instrumental in ensuring supply continuity, operational readiness, and long-term scalability. The Senior Director will partner cross-functionally to enable successful product launches, manage increasing manufacturing complexity, and build the infrastructure needed to support future growth and global expansion. Responsibilities Provide strategic leadership and oversight of external manufacturing across clinical development and commercial supply Establish and govern CDMO partnerships to ensure strong performance, accountability, and alignment with program objectives Define and execute manufacturing strategies to support technology transfer, scale-up, commercialization, and lifecycle management Establish supplier performance metrics and business review process Mentor and build a team of relationship owners responsible for leading the internal supplier relationship teams and serving as the supplier point of contact Ensure supply continuity through proactive risk identification, mitigation planning, and issue escalation across external partners Oversee technology transfer, manufacturing execution, and process performance across a global network of external sites Support commercial launch readiness, including validation, supply planning, and inspection preparedness Partner cross-functionally with Finance, Legal, CMC, Quality, and Supply Chain to drive aligned execution Build scalable, robust external manufacturing infrastructure, operating models, and governance frameworks to support organizational growth Required Qualifications Bachelor’s degree in engineering, life sciences, or related field; advanced degree preferred ~15+ years of experience in pharmaceutical or biotechnology manufacturing, including significant external manufacturing leadership Proven track record managing CDMOs across clinical and commercial supply environments Deep understanding of cGMP regulations, global manufacturing requirements, and regulatory expectations Experience in manufacturing strategy, technology transfer, and commercialization activities Demonstrated ability to lead in complex, multi-program environments and drive cross-functional alignment Strong leadership, communication, and stakeholder management skills Prior experience supporting commercial product launches, conducting RFPs, negotiating supply agreements, and managing high value budgets Experience across multiple supply nodes (API, Drug Product, Packaging, Device) Ability to travel domestically and internationally ~10% Preferred Requirements Experience across multiple modalities (small molecule, peptide, oligonucleotide) A track record of process scale-up, validation and continuous improvement Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.Estimated Pay Range$245,000&mdash;$276,000 USDTo stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Senior Director, External Manufacturing

<div class="content-intro"><p>Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).</p>
<p>Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.</p></div><p><strong>The Opportunity</strong></p>
<p>The Senior Director, Clinical Sciences will be a key member of the Clinical Development team with responsibilities to provide scientific support for ongoing activities. This role will report to a Senior Medical Director and will collaborate cross functionally with R&amp;D, program management, clinical operations, biostatistics, and data management. The selected candidate will support and drive key development activities for clinical studies and overall execution of program Clinical Development Plans (CDP).</p>
<p><strong>Responsibilities</strong></p>
<ul>
<li>Collaborates with the clinical development team in review, analysis, and interpretation of study results.</li>
<li>Provides scientific support on ongoing Phase I to III clinical trials and contributes to the planning and design of upcoming clinical studies.</li>
<li>Performs monitoring and review of study data including labs, safety data, and patient eligibility and consults with the program physician as needed.</li>
<li>Authors and/or reviews clinical trial-related documents including protocols, CRF, informed consent, protocol deviations, monitoring plans and regulatory documents, etc.</li>
<li>Contributes to regulatory documents including CSRs, Investigator’s Brochures, and Clinical sections of INDs, CTAs.</li>
<li>Interacts with external medical/scientific advisors, thought leaders and clinical investigators in the therapeutic areas as well as with internal management and drug development staff to prepare/revise/maintain and efficiently execute the clinical development plan.</li>
</ul>
<p><strong>Required Qualifications</strong></p>
<ul>
<li>Advanced degree (., Ph.D., Pharm.D., Master’s Degree in Science/Medical-related field). PhD or PharmD with 5+ years Clinical Research, Pharmaceutical, or CRO experience, OR Master’s degree with 10+ years of relevant experience.</li>
<li>Knowledge of Phase 1-3 drug development.</li>
<li>Knowledge of clinical trial implementation and sponsor/site interactions for clinical trials.</li>
<li>Well-versed in relevant applications of GCP (Good Clinical Practice), ICH, FDA, EMEA and other relevant guidelines and regulations.</li>
<li>Strong, collaborative team-player.</li>
<li>Excellent attention to detail and communication skills.</li>
</ul>
<p><strong>Preferred Requirements</strong></p>
<ul>
<li>Prior experience working in rare disease within neurology or endocrinology</li>
</ul>
<p><strong>Work Location and Conditions</strong></p>
<ul>
<li>At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.</li>
<li>You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.</li>
<li>You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.</li>
</ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p><strong>Compensation</strong></p>
<p><span data-teams="true">The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.</span></p></div><div class="title">Estimated Pay Range</div><div class="pay-range"><span>$257,000</span><span class="divider">&mdash;</span><span>$289,000 USD</span></div></div></div><div class="content-conclusion"><p><strong>To stay connected with us, follow Amylyx Pharmaceuticals on <a href="https://www.linkedin.com/company/amylyx">LinkedIn</a>. </strong></p>
<p><strong>To return to our website please <a href="https://www.amylyx.com/" target="_blank">click here</a>.</strong></p>
<p>Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.</p>
<p>It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.</p></div>

Senior Medical Director, Clinical Development

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