Director, Process Development and Analytical Development

About Absci Absci is a clinical-stage biotechnology company advancing novel therapeutics using generative AI. Our Integrated Drug Creation™ platform combines cutting-edge AI models with a synthetic biology data engine, enabling the rapid design of innovative therapeutics that address challenging therapeutic targets. Absci is a global company headquartered in Vancouver, WA, and maintains offices in New York City, Switzerland, and Serbia.

Learn more at www.absci.com or follow us on LinkedIn (@absci), X (@Abscibio), and YouTube. As Director, Purification & Analytical Development, you are a strategic leader who guides Absci’s work in biologics. You will lead and mentor teams working on purification and analytical support, and set the strategy for scientific and operational success.

You help your teams manage uncertainty, focus on broad goals, and deliver solutions that impact patients. Your leadership will be instrumental in: Establishing and implementing strategic objectives for Purification and Analytical Development, in partnership with Absci’s executive team. Leading operational units, aligning them with the organizational vision and cascading a clear functional strategy.

Steering our efforts on the frontlines of innovation—empowering the team to pursue what others call impossible.

Responsibilities

  Protein Purification and Analytical Development Oversee the design and execution of purification processes for soluble and membrane-bound proteins. Oversee analytical method development for characterization of therapeutic proteins using a variety of techniques (e.g., ELISA, BLI, HPLC, and MS). Lead troubleshooting and adoption of new technologies for purification and analytical support.

Train and empower scientists in hands-on operation and maintenance of critical instrumentation. Integrate purification and analytical strategies to support drug discovery, selection of lead or drug candidates, antibody characterization, and tech transfers. Developability Assessment Design, implement, and oversee assessment of therapeutic protein developability.

Develop and integrate computational, biophysical, and experimental workflows to assess and mitigate risks such as stability, immunogenicity, and expression challenges. Documentation & Compliance Ensure accurate, comprehensive documentation (SOPs, technical reports, method validations) that meets quality standards. Review and interpret results from standard analytical techniques to assess protein purity, impurities, and process clearance.

Champion use of electronic lab notebooks (ELN), LIMS, UNICORN, Benchling, SoftMax Pro, JMP, and related platforms for data integrity and process tracking. Support tech transfer and contribute to regulatory submission packages as needed. Stakeholder Influence & Communication: Represent Purification & Analytical Development with senior management, executives, and external partners—inspiring trust, negotiating on key matters, and balancing stakeholder priorities.

Advocate for your teams, communicate cross-functionally, and unify diverse perspectives toward essential company goals.

Qualifications

  PhD with 10+ years, or MS with 12+ years of progressive industry experience in drug discovery & analytical science, or related field—with demonstrated success leading teams and organizations through scale, complexity, and ambiguity. Demonstrated mastery of purification, analytical development and developability assessment, with a track record on influencing functional and organizational strategy.

Deep familiarity with the competitive landscape and where Absci’s approach can break the mold. How We Thrive Together: Absci’s Core  Values  We Believe in the Impossible We are one team with one finish line We embrace our differences We deliver Results We do the right thing Innovate because lives depend on it.

Compensation

and Benefits The salary range for this position is $190,000 - 230,000/year. The range provided is based on what we believe is a reasonable estimate for the base salary range for this job at the time of posting. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law Absci offers highly competitive salaries and benefits, including medical, dental, vision insurance, unlimited vacation, parental leave, employee assistance program, voluntary life and disability insurance, annual bonus potential, and 401(k) with a generous company match.

Legal authorization to work in the United States is required. Absci is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, sexual orientation, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, marital status, or any characteristic protected under applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should request the recruiter or hiring manager or contact hiring@absci.com. 

Absci is a biotechnology company that has been leading the way in advancing drug discovery and development through its innovative AI-powered platform. The company's cutting-edge technology has revolutionized the process of creating new therapies, accelerating the pace of scientific breakthroughs in the pharmaceutical industry.

Absci's comprehensive approach to biopharmaceutical innovation has positioned it as a key player in driving the future of healthcare.